Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:55366
• Symbol:Lgr4
• Description:leucine rich repeat containing G protein-coupled receptor 4

DataSource: http://genomecrispr.dkfz.de/#!/results/Lgr4

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
27385368	27385391	11	-	26472758	Jiyoye	viability	GGATGACAACAGCTTGACGGAGG	LGR4	ENSG00000205213	0.6929298638397509	[104]	[127]	5	hSpCas9	negative selection	90253
27385332	27385355	11	+	26472758	Jiyoye	viability	GTAGGGTGGGCAGATTGCTGAGG	LGR4	ENSG00000205213	-2.2768952642282074	[481]	[74]	-8	hSpCas9	negative selection	90254
27380673	27380696	11	+	26472758	Jiyoye	viability	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	0.10051404327182156	[187]	[151]	0	hSpCas9	negative selection	90255
27385272	27385295	11	+	26472758	Jiyoye	viability	GGTTGGTAAATGCAAAGTCAGGG	LGR4	ENSG00000205213	-0.19350535296221327	[645]	[425]	-1	hSpCas9	negative selection	90256
27382203	27382226	11	+	26472758	Jiyoye	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.40717538150587274	[0]	[0]	3	hSpCas9	negative selection	90257
27392455	27392478	11	+	26472758	Jiyoye	viability	GAGTTCTTTCAACCCAGACAAGG	LGR4	ENSG00000205213	0.5242148026960928	[141]	[153]	4	hSpCas9	negative selection	90258
27382186	27382209	11	+	26472758	Jiyoye	viability	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.09328460568392938	[178]	[143]	0	hSpCas9	negative selection	90259
27385368	27385391	11	-	26472758	KBM7	viability	GGATGACAACAGCTTGACGGAGG	LGR4	ENSG00000205213	0.674853113485637	[501,310]	[293,303]	7	hSpCas9	negative selection	281371
27385332	27385355	11	+	26472758	KBM7	viability	GTAGGGTGGGCAGATTGCTGAGG	LGR4	ENSG00000205213	-1.4440278866709384	[1831,1213]	[305,216]	-7	hSpCas9	negative selection	281372
27380673	27380696	11	+	26472758	KBM7	viability	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	0.07244279338312587	[684,525]	[328,267]	0	hSpCas9	negative selection	281373
27385272	27385295	11	+	26472758	KBM7	viability	GGTTGGTAAATGCAAAGTCAGGG	LGR4	ENSG00000205213	0.23033564585416455	[1330,1312]	[878,600]	2	hSpCas9	negative selection	281374
27382203	27382226	11	+	26472758	KBM7	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	-2.894356930335756	[23,8]	[0,0]	-9	hSpCas9	negative selection	281375
27392455	27392478	11	+	26472758	KBM7	viability	GAGTTCTTTCAACCCAGACAAGG	LGR4	ENSG00000205213	-0.2359702712791179	[686,590]	[312,201]	-2	hSpCas9	negative selection	281376
27382186	27382209	11	+	26472758	KBM7	viability	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.5853444491725505	[641,873]	[805,312]	6	hSpCas9	negative selection	281377
27385368	27385391	11	-	26472758	Raji	viability	GGATGACAACAGCTTGACGGAGG	LGR4	ENSG00000205213	0.5351320864019973	[225]	[75]	5	hSpCas9	negative selection	472489
27385332	27385355	11	+	26472758	Raji	viability	GTAGGGTGGGCAGATTGCTGAGG	LGR4	ENSG00000205213	-1.9954272702101759	[755]	[43]	-8	hSpCas9	negative selection	472490
27380673	27380696	11	+	26472758	Raji	viability	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	0.6580761340100096	[283]	[103]	6	hSpCas9	negative selection	472491
27385272	27385295	11	+	26472758	Raji	viability	GGTTGGTAAATGCAAAGTCAGGG	LGR4	ENSG00000205213	0.20159887699125023	[651]	[173]	2	hSpCas9	negative selection	472492
27382203	27382226	11	+	26472758	Raji	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	2.1073835353735992	[0]	[0]	9	hSpCas9	negative selection	472493
27392455	27392478	11	+	26472758	Raji	viability	GAGTTCTTTCAACCCAGACAAGG	LGR4	ENSG00000205213	0.9977590441991011	[286]	[132]	8	hSpCas9	negative selection	472494
27382186	27382209	11	+	26472758	Raji	viability	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.07616480476287935	[326]	[79]	0	hSpCas9	negative selection	472495
27385368	27385391	11	-	26472758	K562	viability	GGATGACAACAGCTTGACGGAGG	LGR4	ENSG00000205213	0.7736272468646017	[254]	[367]	6	hSpCas9	negative selection	663607
27385332	27385355	11	+	26472758	K562	viability	GTAGGGTGGGCAGATTGCTGAGG	LGR4	ENSG00000205213	-4.232167612009917	[1268]	[56]	-9	hSpCas9	negative selection	663608
27380673	27380696	11	+	26472758	K562	viability	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	1.1398017242214178	[578]	[1076]	8	hSpCas9	negative selection	663609
27385272	27385295	11	+	26472758	K562	viability	GGTTGGTAAATGCAAAGTCAGGG	LGR4	ENSG00000205213	0.6182335642187777	[1135]	[1471]	5	hSpCas9	negative selection	663610
27382203	27382226	11	+	26472758	K562	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.24441872766644757	[0]	[0]	2	hSpCas9	negative selection	663611
27392455	27392478	11	+	26472758	K562	viability	GAGTTCTTTCAACCCAGACAAGG	LGR4	ENSG00000205213	0.7976535208653104	[566]	[831]	6	hSpCas9	negative selection	663612
27382186	27382209	11	+	26472758	K562	viability	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.23645901069797015	[726]	[722]	1	hSpCas9	negative selection	663613
27367890	27367913	11	+	26627737	DLD1	viability	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	0.8604294465343276	[516]	[246,327,304]	8	hSpCas9	negative selection	778104
27373628	27373651	11	+	26627737	DLD1	viability	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	0.4568380825324869	[236]	[64,187,61]	4	hSpCas9	negative selection	778105
27380317	27380340	11	-	26627737	DLD1	viability	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	0.5848601964546061	[838]	[450,382,351]	6	hSpCas9	negative selection	778106
27382186	27382209	11	+	26627737	DLD1	viability	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.19626316769043473	[204]	[107,79,37]	2	hSpCas9	negative selection	778107
27385317	27385340	11	-	26627737	DLD1	viability	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	-0.035920483654861224	[1294]	[561,389,253]	0	hSpCas9	negative selection	778108
27367890	27367913	11	+	26627737	GBM cells	viability after 5 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	-0.2013910309099997	[401]	[187,186]	-3	hSpCas9	negative selection	860419
27373628	27373651	11	+	26627737	GBM cells	viability after 5 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	-0.29184162185549195	[217]	[80,109]	-4	hSpCas9	negative selection	860420
27380317	27380340	11	-	26627737	GBM cells	viability after 5 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	0.1649137391960407	[404]	[253,232]	2	hSpCas9	negative selection	860421
27382186	27382209	11	+	26627737	GBM cells	viability after 5 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.19504596889571035	[157]	[71,121]	3	hSpCas9	negative selection	860422
27385317	27385340	11	-	26627737	GBM cells	viability after 5 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	0.11007340103053465	[570]	[342,317]	1	hSpCas9	negative selection	860423
27367890	27367913	11	+	26627737	GBM cells	viability after 13 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	-0.2905358153035382	[401]	[147,202]	-3	hSpCas9	negative selection	942734
27373628	27373651	11	+	26627737	GBM cells	viability after 13 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	-0.46636882394221396	[217]	[62,103]	-5	hSpCas9	negative selection	942735
27380317	27380340	11	-	26627737	GBM cells	viability after 13 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	0.1977733212550873	[404]	[315,199]	2	hSpCas9	negative selection	942736
27382186	27382209	11	+	26627737	GBM cells	viability after 13 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	-0.21624371043982238	[157]	[75,71]	-3	hSpCas9	negative selection	942737
27385317	27385340	11	-	26627737	GBM cells	viability after 13 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	0.008695658652991378	[570]	[298,321]	0	hSpCas9	negative selection	942738
27367890	27367913	11	+	26627737	GBM cells	viability after 21 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	0.2445037306136595	[401]	[264,252]	2	hSpCas9	negative selection	1025049
27373628	27373651	11	+	26627737	GBM cells	viability after 21 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	0.11692484988976352	[217]	[129,126]	1	hSpCas9	negative selection	1025050
27380317	27380340	11	-	26627737	GBM cells	viability after 21 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	-0.1370475530318479	[404]	[197,201]	-1	hSpCas9	negative selection	1025051
27382186	27382209	11	+	26627737	GBM cells	viability after 21 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	-0.1352709252658123	[157]	[97,59]	-1	hSpCas9	negative selection	1025052
27385317	27385340	11	-	26627737	GBM cells	viability after 21 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	0.1489647122047495	[570]	[344,342]	1	hSpCas9	negative selection	1025053
27367890	27367913	11	+	26627737	RPE1	viability after 9 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	0.0050535468485508606	[1251]	[374,416]	0	hSpCas9	negative selection	1107364
27373628	27373651	11	+	26627737	RPE1	viability after 9 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	-0.825518185630161	[841]	[146,150]	-5	hSpCas9	negative selection	1107365
27380317	27380340	11	-	26627737	RPE1	viability after 9 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	1.0610027631732097	[1111]	[645,829]	6	hSpCas9	negative selection	1107366
27382186	27382209	11	+	26627737	RPE1	viability after 9 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.0986667918026296	[311]	[87,125]	0	hSpCas9	negative selection	1107367
27385317	27385340	11	-	26627737	RPE1	viability after 9 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	-0.26734925441840973	[2557]	[753,550]	-2	hSpCas9	negative selection	1107368
27367890	27367913	11	+	26627737	RPE1	viability after 12 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	-0.08141339898028122	[1251]	[280,356]	0	hSpCas9	negative selection	1189679
27373628	27373651	11	+	26627737	RPE1	viability after 12 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	-0.721127935100812	[841]	[110,164]	-5	hSpCas9	negative selection	1189680
27380317	27380340	11	-	26627737	RPE1	viability after 12 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	0.890093827917871	[1111]	[525,582]	5	hSpCas9	negative selection	1189681
27382186	27382209	11	+	26627737	RPE1	viability after 12 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	-0.12196904295221844	[311]	[43,111]	-1	hSpCas9	negative selection	1189682
27385317	27385340	11	-	26627737	RPE1	viability after 12 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	-0.23444114877765898	[2557]	[725,433]	-1	hSpCas9	negative selection	1189683
27367890	27367913	11	+	26627737	RPE1	viability after 15 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	-0.4355946497963811	[1251]	[381,145]	-3	hSpCas9	negative selection	1271994
27373628	27373651	11	+	26627737	RPE1	viability after 15 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	-1.0802037635997412	[841]	[75,147]	-6	hSpCas9	negative selection	1271995
27380317	27380340	11	-	26627737	RPE1	viability after 15 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	1.2144620839587457	[1111]	[788,672]	7	hSpCas9	negative selection	1271996
27382186	27382209	11	+	26627737	RPE1	viability after 15 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.6786732223469094	[311]	[125,155]	4	hSpCas9	negative selection	1271997
27385317	27385340	11	-	26627737	RPE1	viability after 15 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	-0.6060316114636233	[2557]	[564,388]	-4	hSpCas9	negative selection	1271998
27367890	27367913	11	+	26627737	RPE1	viability after 18 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	-0.3961634091998483	[1251]	[190,326]	-2	hSpCas9	negative selection	1354309
27373628	27373651	11	+	26627737	RPE1	viability after 18 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	-0.7069534670379669	[841]	[115,163]	-4	hSpCas9	negative selection	1354310
27380317	27380340	11	-	26627737	RPE1	viability after 18 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	1.0645311345586175	[1111]	[660,591]	6	hSpCas9	negative selection	1354311
27382186	27382209	11	+	26627737	RPE1	viability after 18 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	-0.25788083671775297	[311]	[67,72]	-2	hSpCas9	negative selection	1354312
27385317	27385340	11	-	26627737	RPE1	viability after 18 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	-0.08322233975297211	[2557]	[669,631]	0	hSpCas9	negative selection	1354313
27367890	27367913	11	+	26627737	HeLa	viability after 8 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	0.5487642648714353	[455]	[342,287,253]	5	hSpCas9	negative selection	1436624
27373628	27373651	11	+	26627737	HeLa	viability after 8 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	-0.6728897471941949	[398]	[149,124,63]	-6	hSpCas9	negative selection	1436625
27380317	27380340	11	-	26627737	HeLa	viability after 8 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	0.7361904529908145	[558]	[390,246,562]	6	hSpCas9	negative selection	1436626
27382186	27382209	11	+	26627737	HeLa	viability after 8 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.632125277529007	[162]	[178,85,81]	5	hSpCas9	negative selection	1436627
27385317	27385340	11	-	26627737	HeLa	viability after 8 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	0.6071775357623023	[492]	[258,343,359]	5	hSpCas9	negative selection	1436628
27367890	27367913	11	+	26627737	HeLa	viability after 12 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	0.49304274528445113	[455]	[329,194,279]	4	hSpCas9	negative selection	1518939
27373628	27373651	11	+	26627737	HeLa	viability after 12 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	-0.39286101414828406	[398]	[183,110,84]	-3	hSpCas9	negative selection	1518940
27380317	27380340	11	-	26627737	HeLa	viability after 12 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	0.7965547324051183	[558]	[493,301,420]	6	hSpCas9	negative selection	1518941
27382186	27382209	11	+	26627737	HeLa	viability after 12 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.6661930103895009	[162]	[225,79,20]	5	hSpCas9	negative selection	1518942
27385317	27385340	11	-	26627737	HeLa	viability after 12 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	0.6236947462294623	[492]	[255,361,316]	5	hSpCas9	negative selection	1518943
27367890	27367913	11	+	26627737	HeLa	viability after 15 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	0.4699846314060343	[455]	[167,377,223]	4	hSpCas9	negative selection	1601254
27373628	27373651	11	+	26627737	HeLa	viability after 15 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	-0.47497113215688086	[398]	[133,79,137]	-4	hSpCas9	negative selection	1601255
27380317	27380340	11	-	26627737	HeLa	viability after 15 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	0.5296714242413718	[558]	[235,213,553]	4	hSpCas9	negative selection	1601256
27382186	27382209	11	+	26627737	HeLa	viability after 15 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.07456996913164082	[162]	[90,76,38]	0	hSpCas9	negative selection	1601257
27385317	27385340	11	-	26627737	HeLa	viability after 15 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	0.6138268528512629	[492]	[292,231,403]	5	hSpCas9	negative selection	1601258
27367890	27367913	11	+	26627737	HeLa	viability after 18 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	0.44226679488769705	[455]	[111,301,223]	3	hSpCas9	negative selection	1683569
27373628	27373651	11	+	26627737	HeLa	viability after 18 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	-0.516845242047683	[398]	[89,57,137]	-4	hSpCas9	negative selection	1683570
27380317	27380340	11	-	26627737	HeLa	viability after 18 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	0.522641262480867	[558]	[152,179,553]	4	hSpCas9	negative selection	1683571
27382186	27382209	11	+	26627737	HeLa	viability after 18 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.05894206776685751	[162]	[60,61,38]	0	hSpCas9	negative selection	1683572
27385317	27385340	11	-	26627737	HeLa	viability after 18 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	0.5897808048713856	[492]	[189,187,403]	5	hSpCas9	negative selection	1683573
27367890	27367913	11	+	26627737	HCT116	viability after 6 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	0.7041303553348135	[789]	[75,271]	4	hSpCas9	negative selection	1765884
27373628	27373651	11	+	26627737	HCT116	viability after 6 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	1.4616482352945428	[352]	[21,224]	7	hSpCas9	negative selection	1765885
27380317	27380340	11	-	26627737	HCT116	viability after 6 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	2.6748553720246138	[582]	[864,430]	9	hSpCas9	negative selection	1765886
27382186	27382209	11	+	26627737	HCT116	viability after 6 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	-1.2925782976630589	[304]	[45,4]	-6	hSpCas9	negative selection	1765887
27385317	27385340	11	-	26627737	HCT116	viability after 6 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	1.1978789863487302	[1048]	[668,217]	6	hSpCas9	negative selection	1765888
27367890	27367913	11	+	26627737	HCT116	viability after 8 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	0.5023346726519007	[363]	[230,303,315]	5	hSpCas9	negative selection	1848199
27373628	27373651	11	+	26627737	HCT116	viability after 8 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	1.276272810937457	[103]	[97,204,112]	8	hSpCas9	negative selection	1848200
27380317	27380340	11	-	26627737	HCT116	viability after 8 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	-0.8559241843870597	[815]	[289,204,250]	-8	hSpCas9	negative selection	1848201
27382186	27382209	11	+	26627737	HCT116	viability after 8 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	-0.6523372210928244	[244]	[113,42,100]	-7	hSpCas9	negative selection	1848202
27385317	27385340	11	-	26627737	HCT116	viability after 8 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	-0.17041411366067938	[808]	[440,339,407]	-2	hSpCas9	negative selection	1848203
27367890	27367913	11	+	26627737	HCT116	viability after 9 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	0.23912629845289896	[789]	[253,244]	1	hSpCas9	negative selection	1930514
27373628	27373651	11	+	26627737	HCT116	viability after 9 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	-0.7859450580207844	[352]	[95,21]	-5	hSpCas9	negative selection	1930515
27380317	27380340	11	-	26627737	HCT116	viability after 9 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	-0.01870182213884594	[582]	[256,71]	0	hSpCas9	negative selection	1930516
27382186	27382209	11	+	26627737	HCT116	viability after 9 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.9778222980053832	[304]	[65,234]	6	hSpCas9	negative selection	1930517
27385317	27385340	11	-	26627737	HCT116	viability after 9 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	1.179144759818616	[1048]	[583,673]	7	hSpCas9	negative selection	1930518
27367890	27367913	11	+	26627737	HCT116	viability after 12 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	0.3375867585185304	[363]	[325,209,180]	3	hSpCas9	negative selection	2012829
27373628	27373651	11	+	26627737	HCT116	viability after 12 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	0.9801132567276519	[103]	[108,93,119]	8	hSpCas9	negative selection	2012830
27380317	27380340	11	-	26627737	HCT116	viability after 12 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	-0.4159746809303746	[815]	[336,367,258]	-4	hSpCas9	negative selection	2012831
27382186	27382209	11	+	26627737	HCT116	viability after 12 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	-0.7645454528103441	[244]	[56,74,96]	-7	hSpCas9	negative selection	2012832
27385317	27385340	11	-	26627737	HCT116	viability after 12 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	-0.44695422511141103	[808]	[304,300,329]	-5	hSpCas9	negative selection	2012833
27367890	27367913	11	+	26627737	HCT116	viability after 15 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	0.4021787596362612	[363]	[347,172,315]	4	hSpCas9	negative selection	2095144
27373628	27373651	11	+	26627737	HCT116	viability after 15 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	0.9581602702197192	[103]	[124,90,132]	7	hSpCas9	negative selection	2095145
27380317	27380340	11	-	26627737	HCT116	viability after 15 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	-1.2052603580151542	[815]	[177,254,173]	-8	hSpCas9	negative selection	2095146
27382186	27382209	11	+	26627737	HCT116	viability after 15 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	-0.9082059557221567	[244]	[100,44,81]	-7	hSpCas9	negative selection	2095147
27385317	27385340	11	-	26627737	HCT116	viability after 15 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	0.11203928129847984	[808]	[797,293,450]	1	hSpCas9	negative selection	2095148
27367890	27367913	11	+	26627737	HCT116	viability after 18 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	0.33176653195158884	[363]	[235,124,313]	3	hSpCas9	negative selection	2177459
27373628	27373651	11	+	26627737	HCT116	viability after 18 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	0.802364272744537	[103]	[98,14,156]	6	hSpCas9	negative selection	2177460
27380317	27380340	11	-	26627737	HCT116	viability after 18 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	-0.23963543498472584	[815]	[297,334,370]	-2	hSpCas9	negative selection	2177461
27382186	27382209	11	+	26627737	HCT116	viability after 18 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	-1.258500820783667	[244]	[36,41,70]	-8	hSpCas9	negative selection	2177462
27385317	27385340	11	-	26627737	HCT116	viability after 18 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	-0.7426204501155337	[808]	[257,165,283]	-6	hSpCas9	negative selection	2177463
27400587	27400610	11	-	25494202	A375	resistance to PLX-4720 (puromycin)	AATCGCTTGAACCTGGGAGGTAG	LGR4	ENSG00000205213	0.7552978455787054	[33,39]	[12,13]	3	dCas9-VP64	positive selection	2413202
27452661	27452684	11	+	25494202	A375	resistance to PLX-4720 (puromycin)	TCGCCCCGGCTGGAGTGCAGTGG	LGR4	ENSG00000205213	-0.21202295820544315	[11,7]	[0,1]	-1	dCas9-VP64	positive selection	2445446
27400587	27400610	11	-	25494202	A375	resistance to PLX-4720 (zeocin)	AATCGCTTGAACCTGGGAGGTAG	LGR4	ENSG00000205213	1.0802526276452251	[21,53]	[11,38]	7	dCas9-VP64	positive selection	2508457
27452661	27452684	11	+	25494202	A375	resistance to PLX-4720 (zeocin)	TCGCCCCGGCTGGAGTGCAGTGG	LGR4	ENSG00000205213	1.758955550774001	[111,40]	[35,131]	8	dCas9-VP64	positive selection	2540701
27380674	27380697	11	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	-0.05758451660877251	[4,4]	[3,2]	-1	hSpCas9	positive selection	2999340
27380264	27380287	11	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TTACTTACAGACTTTCCAGGTGG	LGR4	ENSG00000205213	0.14197500494044069	[5,5]	[5,4]	3	hSpCas9	positive selection	2999341
27380674	27380697	11	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	0.2815731913097897	[4,4]	[4,2]	5	hSpCas9	positive selection	3067198
27380264	27380287	11	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TTACTTACAGACTTTCCAGGTGG	LGR4	ENSG00000205213	0.5873093187998418	[5,5]	[5,5]	8	hSpCas9	positive selection	3067199
27412807	27412830		+	24336571	A375	resistance to PLX after 7 days	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.1413445876005175	[8,7]	[6,7]	-4	hSpCas9	positive selection	3124552
27384325	27384348		+	24336571	A375	resistance to PLX after 7 days	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	-0.11562144567627416	[10,11]	[10,9]	-4	hSpCas9	positive selection	3124553
27412783	27412806		+	24336571	A375	resistance to PLX after 7 days	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	-0.33628330771722603	[4,2]	[2,3]	-8	hSpCas9	positive selection	3124554
27384358	27384381		+	24336571	A375	resistance to PLX after 7 days	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	-0.09969285620176166	[18,18]	[17,17]	-3	hSpCas9	positive selection	3124555
27412807	27412830		+	24336571	A375	resistance to PLX after 14 days	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.26817047669704264	[10,5]	[2,2]	-3	hSpCas9	positive selection	3182345
27384325	27384348		+	24336571	A375	resistance to PLX after 14 days	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	-0.16207122788363276	[10,8]	[3,3]	-2	hSpCas9	positive selection	3182346
27412783	27412806		+	24336571	A375	resistance to PLX after 14 days	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.8572224433344338	[1,3]	[1,2]	7	hSpCas9	positive selection	3182347
27384358	27384381		+	24336571	A375	resistance to PLX after 14 days	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	-0.13384099482083328	[16,17]	[6,6]	-1	hSpCas9	positive selection	3182348
27412807	27412830		+	24336571	A375	viability after 7 days	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	0.1217683841195022	[7]	[8,7]	1	hSpCas9	negative selection	3240138
27384325	27384348		+	24336571	A375	viability after 7 days	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	-0.39494014038018577	[15]	[10,11]	-5	hSpCas9	negative selection	3240139
27412783	27412806		+	24336571	A375	viability after 7 days	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	-0.3573490991377497	[5]	[4,2]	-5	hSpCas9	negative selection	3240140
27384358	27384381		+	24336571	A375	viability after 7 days	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.5143068559126874	[13]	[18,18]	7	hSpCas9	negative selection	3240141
27412807	27412830		+	24336571	A375	viability after 14 days	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	0.12538452251476684	[7]	[10,5]	1	hSpCas9	negative selection	3297931
27384325	27384348		+	24336571	A375	viability after 14 days	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	-0.5823155340107924	[15]	[10,8]	-6	hSpCas9	negative selection	3297932
27412783	27412806		+	24336571	A375	viability after 14 days	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	-0.7565738778488553	[5]	[1,3]	-7	hSpCas9	negative selection	3297933
27384358	27384381		+	24336571	A375	viability after 14 days	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.3825442033669243	[13]	[16,17]	5	hSpCas9	negative selection	3297934
27382177	27382200	11	+	27383988	293T	resistance to West Nile virus (flavivirus)	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.02850752094995433	[149,149]	[0,0]	0	hSpCas9	positive selection	3377082
27412807	27412830	11	+	27383988	293T	resistance to West Nile virus (flavivirus)	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	0.11777485904704146	[140,140]	[0,0]	0	hSpCas9	positive selection	3377083
27412783	27412806	11	+	27383988	293T	resistance to West Nile virus (flavivirus)	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.1280431945008686	[139,139]	[0,0]	0	hSpCas9	positive selection	3377084
27380673	27380696	11	+	26780180	HT29	viability (Avana library 4 designs)	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	-0.402459069716793	[]	[]	-6	hSpCas9	negative selection	3436887
27380263	27380286	11	+	26780180	HT29	viability (Avana library 4 designs)	TTACTTACAGACTTTCCAGGTGG	LGR4	ENSG00000205213	-0.456018411011415	[]	[]	-7	hSpCas9	negative selection	3436888
27380263	27380286	11	+	26780180	A375	viability (Avana lentiCRISPRv2)	TTACTTACAGACTTTCCAGGTGG	LGR4	ENSG00000205213	-0.431288403482422	[]	[]	0	hSpCas9	negative selection	3525330
27380673	27380696	11	+	26780180	A375	viability (Avana lentiCRISPRv2)	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	2.84803933057101	[]	[]	4	hSpCas9	negative selection	3525331
27385431	27385454	11	-	26780180	A375	viability (Avana lentiCRISPRv2)	CCATATTACCTCAGTCCCCGAGG	LGR4	ENSG00000205213	1.47634060168858	[]	[]	2	hSpCas9	negative selection	3525332
27385368	27385391	11	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGATGACAACAGCTTGACGGAGG	LGR4	ENSG00000205213	2.10488885159426	[]	[]	3	hSpCas9	negative selection	3525333
27380263	27380286	11	+	26780180	A375	viability (Avana lentiGuide)	TTACTTACAGACTTTCCAGGTGG	LGR4	ENSG00000205213	-3.66078005384962	[]	[]	-6	hSpCas9	negative selection	3633989
27380673	27380696	11	+	26780180	A375	viability (Avana lentiGuide)	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	-4.84029441588563	[]	[]	-8	hSpCas9	negative selection	3633990
27385431	27385454	11	-	26780180	A375	viability (Avana lentiGuide)	CCATATTACCTCAGTCCCCGAGG	LGR4	ENSG00000205213	-2.00147427806022	[]	[]	-3	hSpCas9	negative selection	3633991
27385368	27385391	11	-	26780180	A375	viability (Avana lentiGuide)	GGATGACAACAGCTTGACGGAGG	LGR4	ENSG00000205213	0.131085921647715	[]	[]	0	hSpCas9	negative selection	3633992
27380263	27380286	11	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTACTTACAGACTTTCCAGGTGG	LGR4	ENSG00000205213	-0.07170561581110502	[6]	[6,5]	-1	hSpCas9	positive selection	3742648
27380673	27380696	11	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	0.33898608282066733	[4]	[5,6]	8	hSpCas9	positive selection	3742649
27385431	27385454	11	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CCATATTACCTCAGTCCCCGAGG	LGR4	ENSG00000205213	0.15587886339929866	[5]	[6,5]	4	hSpCas9	positive selection	3742650
27385368	27385391	11	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGATGACAACAGCTTGACGGAGG	LGR4	ENSG00000205213	0.023754449070284317	[4]	[3,4]	0	hSpCas9	positive selection	3742651
27380263	27380286	11	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTACTTACAGACTTTCCAGGTGG	LGR4	ENSG00000205213	0.3407715987839283	[6]	[7,6]	8	hSpCas9	positive selection	3851255
27380673	27380696	11	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	0.3055599695003761	[5]	[5,5]	8	hSpCas9	positive selection	3851256
27385431	27385454	11	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CCATATTACCTCAGTCCCCGAGG	LGR4	ENSG00000205213	0.2579502399771119	[6]	[6,7]	7	hSpCas9	positive selection	3851257
27385368	27385391	11	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGATGACAACAGCTTGACGGAGG	LGR4	ENSG00000205213	0.20589931181050464	[4]	[5,3]	5	hSpCas9	positive selection	3851258
27412807	27412830	11	+	26780180	A375	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	1.0629487932125	[]	[]	5	hSpCas9	negative selection	3956919
27384325	27384348	11	+	26780180	A375	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	1.12612297619154	[]	[]	5	hSpCas9	negative selection	3956920
27412783	27412806	11	+	26780180	A375	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	1.28384604089492	[]	[]	7	hSpCas9	negative selection	3956921
27384358	27384381	11	+	26780180	A375	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	1.5582535282189	[]	[]	8	hSpCas9	negative selection	3956922
27382177	27382200	11	+	26780180	A375	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.908090769617637	[]	[]	4	hSpCas9	negative selection	3956923
27382203	27382226	11	+	26780180	A375	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	1.16004001549783	[]	[]	6	hSpCas9	negative selection	3956924
27412807	27412830	11	+	26780180	HT29	viability (GeCKOv2 library)	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	1.74315399744075	[]	[]	8	hSpCas9	negative selection	4064885
27384325	27384348	11	+	26780180	HT29	viability (GeCKOv2 library)	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	1.94413727718499	[]	[]	9	hSpCas9	negative selection	4064886
27412783	27412806	11	+	26780180	HT29	viability (GeCKOv2 library)	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.688428446804497	[]	[]	2	hSpCas9	negative selection	4064887
27384358	27384381	11	+	26780180	HT29	viability (GeCKOv2 library)	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.559980517396564	[]	[]	2	hSpCas9	negative selection	4064888
27382177	27382200	11	+	26780180	HT29	viability (GeCKOv2 library)	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.771779922226308	[]	[]	3	hSpCas9	negative selection	4064889
27382203	27382226	11	+	26780180	HT29	viability (GeCKOv2 library)	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	-0.0860092258016518	[]	[]	-2	hSpCas9	negative selection	4064890
27412807	27412830	11	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.3912051954818574	[2]	[0,1]	-7	hSpCas9	positive selection	4148614
27384325	27384348	11	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	-0.1544718219098248	[3]	[2,1]	-4	hSpCas9	positive selection	4148615
27412783	27412806	11	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.32057378996774655	[1]	[1,1]	7	hSpCas9	positive selection	4148616
27384358	27384381	11	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.0955973520184689	[3]	[2,2]	2	hSpCas9	positive selection	4148617
27412807	27412830	11	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	1.866082408132509	[1]	[0,1,2,5]	9	hSpCas9	positive selection	4212636
27384325	27384348	11	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	-0.2964989141463285	[2]	[1,0,0,0]	-4	hSpCas9	positive selection	4212637
27412783	27412806	11	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.7159229609926947	[2]	[3,3,1,0]	4	hSpCas9	positive selection	4212638
27384358	27384381	11	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.6540577288999045	[3]	[4,2,3,0]	4	hSpCas9	positive selection	4212639
27382203	27382226	11	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.1809214305636298	[2]	[2,1]	3	hSpCas9	positive selection	4280078
27384325	27384348	11	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	-0.49008057469089866	[3]	[2,0]	-8	hSpCas9	positive selection	4280079
27384358	27384381	11	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	-0.007373639396482612	[3]	[3,2]	0	hSpCas9	positive selection	4280080
27382177	27382200	11	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.30702046678665795	[2]	[2,2]	6	hSpCas9	positive selection	4344334
27412807	27412830	11	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.2375358032984594	[2]	[1,1]	-5	hSpCas9	positive selection	4344335
27412783	27412806	11	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	-0.0202758685747082	[2]	[2,1]	0	hSpCas9	positive selection	4344336
27382204	27382226	11	+	27760321	OCIAML3	viability	GAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	-0.3594270545281538	[263,227]	[116,191]	-4	hSpCas9	negative selection	4414319
27384343	27384365	11	-	27760321	OCIAML3	viability	TTTGATGGACTAGATAACCTGG	LGR4	ENSG00000205213	0.19751424935286632	[80,51]	[76,34]	2	hSpCas9	negative selection	4414320
27385256	27385278	11	+	27760321	OCIAML3	viability	ACTACCAGGCTTGAAAGGTTGG	LGR4	ENSG00000205213	0.7693685485032268	[478,419]	[600,593]	8	hSpCas9	negative selection	4414321
27373978	27374000	11	+	27760321	OCIAML3	viability	TTAGTTATTGGCCCAAGTGTGG	LGR4	ENSG00000205213	0.5787009429686305	[355,332]	[376,435]	7	hSpCas9	negative selection	4414322
27382204	27382226	11	+	27760321	OCIAML2	viability	GAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	-0.04617527188603432	[263,227]	[202,177]	0	hSpCas9	negative selection	4497782
27384343	27384365	11	-	27760321	OCIAML2	viability	TTTGATGGACTAGATAACCTGG	LGR4	ENSG00000205213	0.20058552331268098	[80,51]	[72,44]	2	hSpCas9	negative selection	4497783
27385256	27385278	11	+	27760321	OCIAML2	viability	ACTACCAGGCTTGAAAGGTTGG	LGR4	ENSG00000205213	0.5302520726782082	[478,419]	[413,668]	7	hSpCas9	negative selection	4497784
27373978	27374000	11	+	27760321	OCIAML2	viability	TTAGTTATTGGCCCAAGTGTGG	LGR4	ENSG00000205213	0.41990242008664175	[355,332]	[366,380]	6	hSpCas9	negative selection	4497785
27382204	27382226	11	+	27760321	MV411	viability	GAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.6483491560416255	[263,227]	[190,347]	5	hSpCas9	negative selection	4581245
27384343	27384365	11	-	27760321	MV411	viability	TTTGATGGACTAGATAACCTGG	LGR4	ENSG00000205213	0.06908617579582232	[80,51]	[0,111]	0	hSpCas9	negative selection	4581246
27385256	27385278	11	+	27760321	MV411	viability	ACTACCAGGCTTGAAAGGTTGG	LGR4	ENSG00000205213	0.8467518306876615	[478,419]	[463,634]	6	hSpCas9	negative selection	4581247
27373978	27374000	11	+	27760321	MV411	viability	TTAGTTATTGGCCCAAGTGTGG	LGR4	ENSG00000205213	0.47308772944780464	[355,332]	[232,439]	3	hSpCas9	negative selection	4581248
27382204	27382226	11	+	27760321	HL60	viability	GAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	1.0736105684375918	[263,227]	[447,393]	9	hSpCas9	negative selection	4664708
27384343	27384365	11	-	27760321	HL60	viability	TTTGATGGACTAGATAACCTGG	LGR4	ENSG00000205213	1.8612837283913084	[80,51]	[193,194]	9	hSpCas9	negative selection	4664709
27385256	27385278	11	+	27760321	HL60	viability	ACTACCAGGCTTGAAAGGTTGG	LGR4	ENSG00000205213	-0.6411741065038836	[478,419]	[232,236]	-6	hSpCas9	negative selection	4664710
27373978	27374000	11	+	27760321	HL60	viability	TTAGTTATTGGCCCAAGTGTGG	LGR4	ENSG00000205213	0.6937922187840413	[355,332]	[436,474]	7	hSpCas9	negative selection	4664711
27382204	27382226	11	+	27760321	HT1080	viability	GAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	-6.337546114314766	[227,177]	[0,0]	-9	hSpCas9	negative selection	4748171
27384343	27384365	11	-	27760321	HT1080	viability	TTTGATGGACTAGATAACCTGG	LGR4	ENSG00000205213	2.723585070337836	[51,40]	[120,123]	9	hSpCas9	negative selection	4748172
27385256	27385278	11	+	27760321	HT1080	viability	ACTACCAGGCTTGAAAGGTTGG	LGR4	ENSG00000205213	-0.11912122490714952	[419,327]	[98,178]	0	hSpCas9	negative selection	4748173
27373978	27374000	11	+	27760321	HT1080	viability	TTAGTTATTGGCCCAAGTGTGG	LGR4	ENSG00000205213	1.1060211471872097	[332,259]	[364,132]	6	hSpCas9	negative selection	4748174
27382204	27382226	11	+	27760321	HT29	viability after 7 days	GAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.25426666799746767	[227,177]	[344,304,288]	4	hSpCas9	negative selection	4831634
27384343	27384365	11	-	27760321	HT29	viability after 7 days	TTTGATGGACTAGATAACCTGG	LGR4	ENSG00000205213	-0.6490545216296528	[51,40]	[59,34,22]	-7	hSpCas9	negative selection	4831635
27385256	27385278	11	+	27760321	HT29	viability after 7 days	ACTACCAGGCTTGAAAGGTTGG	LGR4	ENSG00000205213	0.38128056034285523	[419,327]	[453,787,611]	6	hSpCas9	negative selection	4831636
27373978	27374000	11	+	27760321	HT29	viability after 7 days	TTAGTTATTGGCCCAAGTGTGG	LGR4	ENSG00000205213	0.18207020604998447	[332,259]	[264,670,339]	2	hSpCas9	negative selection	4831637
27382204	27382226	11	+	27760321	HT29	viability after 25 days	GAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.18368429690393262	[227,177]	[210,330,249]	1	hSpCas9	negative selection	4915097
27384343	27384365	11	-	27760321	HT29	viability after 25 days	TTTGATGGACTAGATAACCTGG	LGR4	ENSG00000205213	0.35356728702450546	[51,40]	[68,80,51]	4	hSpCas9	negative selection	4915098
27385256	27385278	11	+	27760321	HT29	viability after 25 days	ACTACCAGGCTTGAAAGGTTGG	LGR4	ENSG00000205213	0.6488767820627703	[419,327]	[462,842,721]	7	hSpCas9	negative selection	4915099
27373978	27374000	11	+	27760321	HT29	viability after 25 days	TTAGTTATTGGCCCAAGTGTGG	LGR4	ENSG00000205213	0.14743718855189406	[332,259]	[357,379,389]	1	hSpCas9	negative selection	4915100
27382204	27382226	11	+	27760321	HT29	viability after 22 days	GAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.1683830977546973	[227,177]	[120,415,257]	1	hSpCas9	negative selection	4998560
27384343	27384365	11	-	27760321	HT29	viability after 22 days	TTTGATGGACTAGATAACCTGG	LGR4	ENSG00000205213	0.1505271187527626	[51,40]	[92,47,36]	1	hSpCas9	negative selection	4998561
27385256	27385278	11	+	27760321	HT29	viability after 22 days	ACTACCAGGCTTGAAAGGTTGG	LGR4	ENSG00000205213	0.7886200826895164	[419,327]	[794,631,812]	8	hSpCas9	negative selection	4998562
27373978	27374000	11	+	27760321	HT29	viability after 22 days	TTAGTTATTGGCCCAAGTGTGG	LGR4	ENSG00000205213	0.043009489038251386	[332,259]	[384,484,186]	0	hSpCas9	negative selection	4998563
27382204	27382226	11	+	27760321	HT29	viability after 19 days	GAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.5539068656416944	[227,177]	[248,511,254]	5	hSpCas9	negative selection	5082023
27384343	27384365	11	-	27760321	HT29	viability after 19 days	TTTGATGGACTAGATAACCTGG	LGR4	ENSG00000205213	1.5902310787014962	[51,40]	[133,348,0]	9	hSpCas9	negative selection	5082024
27385256	27385278	11	+	27760321	HT29	viability after 19 days	ACTACCAGGCTTGAAAGGTTGG	LGR4	ENSG00000205213	0.9815256512321118	[419,327]	[961,696,884]	8	hSpCas9	negative selection	5082025
27373978	27374000	11	+	27760321	HT29	viability after 19 days	TTAGTTATTGGCCCAAGTGTGG	LGR4	ENSG00000205213	0.0356492232559848	[332,259]	[297,435,304]	0	hSpCas9	negative selection	5082026
27382204	27382226	11	+	27760321	HT29	viability after 16 days	GAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.20135553079797397	[227,177]	[394,261,138]	2	hSpCas9	negative selection	5165486
27384343	27384365	11	-	27760321	HT29	viability after 16 days	TTTGATGGACTAGATAACCTGG	LGR4	ENSG00000205213	1.3077537071772811	[51,40]	[106,148,127]	9	hSpCas9	negative selection	5165487
27385256	27385278	11	+	27760321	HT29	viability after 16 days	ACTACCAGGCTTGAAAGGTTGG	LGR4	ENSG00000205213	0.5123020199277653	[419,327]	[643,630,518]	6	hSpCas9	negative selection	5165488
27373978	27374000	11	+	27760321	HT29	viability after 16 days	TTAGTTATTGGCCCAAGTGTGG	LGR4	ENSG00000205213	-0.320196895722619	[332,259]	[307,344,145]	-3	hSpCas9	negative selection	5165489
27382204	27382226	11	+	27760321	HT29	viability after 13 days	GAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.3581644190672645	[227,177]	[473,228,207]	4	hSpCas9	negative selection	5248949
27384343	27384365	11	-	27760321	HT29	viability after 13 days	TTTGATGGACTAGATAACCTGG	LGR4	ENSG00000205213	0.2063005699854097	[51,40]	[68,109,10]	2	hSpCas9	negative selection	5248950
27385256	27385278	11	+	27760321	HT29	viability after 13 days	ACTACCAGGCTTGAAAGGTTGG	LGR4	ENSG00000205213	0.4667746957096955	[419,327]	[627,591,579]	6	hSpCas9	negative selection	5248951
27373978	27374000	11	+	27760321	HT29	viability after 13 days	TTAGTTATTGGCCCAAGTGTGG	LGR4	ENSG00000205213	-0.10881383647081833	[332,259]	[313,205,429]	-1	hSpCas9	negative selection	5248952
27382204	27382226	11	+	27760321	HT29	viability after 10 days	GAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.253722471083053	[227,177]	[164,472,273]	3	hSpCas9	negative selection	5332412
27384343	27384365	11	-	27760321	HT29	viability after 10 days	TTTGATGGACTAGATAACCTGG	LGR4	ENSG00000205213	-0.40460987579242635	[51,40]	[36,93,2]	-5	hSpCas9	negative selection	5332413
27385256	27385278	11	+	27760321	HT29	viability after 10 days	ACTACCAGGCTTGAAAGGTTGG	LGR4	ENSG00000205213	0.26196751340406604	[419,327]	[721,591,370]	3	hSpCas9	negative selection	5332414
27373978	27374000	11	+	27760321	HT29	viability after 10 days	TTAGTTATTGGCCCAAGTGTGG	LGR4	ENSG00000205213	-0.09899199688130789	[332,259]	[214,445,377]	-1	hSpCas9	negative selection	5332415
27382204	27382226	11	+	27760321	MOLM13	viability	GAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.3204752267882661	[263,227]	[295,67]	2	hSpCas9	negative selection	5415875
27384343	27384365	11	-	27760321	MOLM13	viability	TTTGATGGACTAGATAACCTGG	LGR4	ENSG00000205213	-1.1495871541603213	[80,51]	[0,29]	-6	hSpCas9	negative selection	5415876
27385256	27385278	11	+	27760321	MOLM13	viability	ACTACCAGGCTTGAAAGGTTGG	LGR4	ENSG00000205213	1.278831965145702	[478,419]	[814,442]	8	hSpCas9	negative selection	5415877
27373978	27374000	11	+	27760321	MOLM13	viability	TTAGTTATTGGCCCAAGTGTGG	LGR4	ENSG00000205213	1.135659761305985	[355,332]	[261,567]	7	hSpCas9	negative selection	5415878
27382203	27382226	11	+	27260156	BXPC3	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.6320963432031125	[214]	[286,330,354,436]	9	hSpCas9	negative selection	5552538
27384325	27384348	11	+	27260156	BXPC3	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.11088083326652262	[464]	[413,474,648,582]	2	hSpCas9	negative selection	5552539
27384358	27384381	11	+	27260156	BXPC3	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.030349530982298534	[929]	[915,1074,971,1006]	0	hSpCas9	negative selection	5552540
27382177	27382200	11	+	27260156	BXPC3	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	-0.07316009026389536	[305]	[269,308,304,337]	-2	hSpCas9	negative selection	5616794
27412807	27412830	11	+	27260156	BXPC3	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.016687691727110154	[311]	[203,339,315,455]	0	hSpCas9	negative selection	5616795
27412783	27412806	11	+	27260156	BXPC3	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.12944587990861184	[310]	[386,298,317,423]	3	hSpCas9	negative selection	5616796
27382203	27382226	11	+	27260156	A673	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.4111871181629365	[214]	[412,319,282,366]	8	hSpCas9	negative selection	5673789
27384325	27384348	11	+	27260156	A673	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.07300394982669214	[464]	[749,543,427,650]	1	hSpCas9	negative selection	5673790
27384358	27384381	11	+	27260156	A673	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.03628937894533424	[929]	[1084,1101,1144,1245]	0	hSpCas9	negative selection	5673791
27382177	27382200	11	+	27260156	A673	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	-0.009783345639911012	[305]	[372,316,388,382]	0	hSpCas9	negative selection	5738045
27412807	27412830	11	+	27260156	A673	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.2803079866968805	[311]	[269,345,228,387]	-6	hSpCas9	negative selection	5738046
27412783	27412806	11	+	27260156	A673	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.17486730787424826	[310]	[412,445,386,438]	4	hSpCas9	negative selection	5738047
27382203	27382226	11	+	27260156	A375	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	1.09529908573684	[214]	[549,456,514,602]	9	hSpCas9	negative selection	5795040
27384325	27384348	11	+	27260156	A375	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.35112782176907953	[464]	[674,916,639,580]	5	hSpCas9	negative selection	5795041
27384358	27384381	11	+	27260156	A375	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.21596537439602104	[929]	[1157,1606,1589,790]	3	hSpCas9	negative selection	5795042
27382177	27382200	11	+	27260156	A375	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.5007822572718247	[305]	[523,434,599,457]	7	hSpCas9	negative selection	5859296
27412807	27412830	11	+	27260156	A375	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	0.09873253675093624	[311]	[363,606,335,293]	1	hSpCas9	negative selection	5859297
27412783	27412806	11	+	27260156	A375	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.44626243261393717	[310]	[350,734,529,404]	6	hSpCas9	negative selection	5859298
27382203	27382226	11	+	27260156	COLO741	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.189747556122573	[214]	[444,342,172]	4	hSpCas9	negative selection	5916291
27384325	27384348	11	+	27260156	COLO741	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.27158785998021606	[464]	[707,692,745]	6	hSpCas9	negative selection	5916292
27384358	27384381	11	+	27260156	COLO741	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	-0.02558121488241827	[929]	[1280,1186,1049]	0	hSpCas9	negative selection	5916293
27382177	27382200	11	+	27260156	COLO741	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.16116148159822413	[305]	[568,433,326]	3	hSpCas9	negative selection	5980547
27412807	27412830	11	+	27260156	COLO741	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	0.12567602986673798	[311]	[473,508,331]	2	hSpCas9	negative selection	5980548
27412783	27412806	11	+	27260156	COLO741	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.08896270405757312	[310]	[415,393,453]	2	hSpCas9	negative selection	5980549
27382203	27382226	11	+	27260156	CAL120	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.6154693795067782	[214]	[610,363,286]	8	hSpCas9	negative selection	6037542
27384325	27384348	11	+	27260156	CAL120	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.06748768871727814	[464]	[484,566,745]	1	hSpCas9	negative selection	6037543
27384358	27384381	11	+	27260156	CAL120	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.09295495676277343	[929]	[1069,1391,1215]	1	hSpCas9	negative selection	6037544
27382177	27382200	11	+	27260156	CAL120	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.1707609793517399	[305]	[439,618,231]	2	hSpCas9	negative selection	6101798
27412807	27412830	11	+	27260156	CAL120	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	0.011508749606396695	[311]	[257,512,382]	0	hSpCas9	negative selection	6101799
27412783	27412806	11	+	27260156	CAL120	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.3753898572451641	[310]	[619,479,424]	5	hSpCas9	negative selection	6101800
27382203	27382226	11	+	27260156	CADOES1	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.4757742416890228	[214]	[208,366,377,153]	7	hSpCas9	negative selection	6158793
27384325	27384348	11	+	27260156	CADOES1	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.19783593328638532	[464]	[558,430,468,525]	3	hSpCas9	negative selection	6158794
27384358	27384381	11	+	27260156	CADOES1	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.16180641212379476	[929]	[939,923,921,1088]	2	hSpCas9	negative selection	6158795
27382177	27382200	11	+	27260156	CADOES1	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.192327290661699	[305]	[352,324,288,333]	3	hSpCas9	negative selection	6223049
27412807	27412830	11	+	27260156	CADOES1	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.47303378677549845	[311]	[265,223,165,178]	-7	hSpCas9	negative selection	6223050
27412783	27412806	11	+	27260156	CADOES1	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.34301578849648745	[310]	[452,417,342,248]	6	hSpCas9	negative selection	6223051
27382203	27382226	11	+	27260156	EWS502	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.31784608910770784	[214]	[136,399,358,249]	5	hSpCas9	negative selection	6280044
27384325	27384348	11	+	27260156	EWS502	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	-0.019936375548828336	[464]	[397,574,540,430]	0	hSpCas9	negative selection	6280045
27384358	27384381	11	+	27260156	EWS502	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	-0.02811597856824921	[929]	[874,948,1030,1021]	0	hSpCas9	negative selection	6280046
27382177	27382200	11	+	27260156	EWS502	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.07779897382054402	[305]	[309,333,413,311]	1	hSpCas9	negative selection	6344300
27412807	27412830	11	+	27260156	EWS502	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.02980735468890161	[311]	[319,194,320,473]	0	hSpCas9	negative selection	6344301
27412783	27412806	11	+	27260156	EWS502	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.04926668293648884	[310]	[434,237,257,428]	0	hSpCas9	negative selection	6344302
27382203	27382226	11	+	27260156	EW8	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.31125331371479514	[214]	[264,256,191,159]	6	hSpCas9	negative selection	6401295
27384325	27384348	11	+	27260156	EW8	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.06425353617555152	[464]	[405,493,303,387]	1	hSpCas9	negative selection	6401296
27384358	27384381	11	+	27260156	EW8	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	-0.04675452295943494	[929]	[692,908,613,716]	-1	hSpCas9	negative selection	6401297
27382177	27382200	11	+	27260156	EW8	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.03377486037554589	[305]	[291,341,227,161]	0	hSpCas9	negative selection	6465551
27412807	27412830	11	+	27260156	EW8	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.1625784171079463	[311]	[291,303,207,109]	-3	hSpCas9	negative selection	6465552
27412783	27412806	11	+	27260156	EW8	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.15312342767520676	[310]	[266,352,155,363]	3	hSpCas9	negative selection	6465553
27382203	27382226	11	+	27260156	CORL105	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.48711911113881057	[214]	[268,238,467,451]	8	hSpCas9	negative selection	6522546
27384325	27384348	11	+	27260156	CORL105	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	-0.13114956724994553	[464]	[343,567,508,561]	-2	hSpCas9	negative selection	6522547
27384358	27384381	11	+	27260156	CORL105	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	-0.21860667658432564	[929]	[995,850,1204,736]	-4	hSpCas9	negative selection	6522548
27382177	27382200	11	+	27260156	CORL105	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	-0.5209326957916163	[305]	[183,297,247,264]	-7	hSpCas9	negative selection	6586802
27412807	27412830	11	+	27260156	CORL105	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.7374761901517862	[311]	[159,175,233,306]	-8	hSpCas9	negative selection	6586803
27412783	27412806	11	+	27260156	CORL105	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	-0.2527767217156598	[310]	[294,342,316,267]	-5	hSpCas9	negative selection	6586804
27382203	27382226	11	+	27260156	HS294T	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.3856182390889391	[214]	[101,144,109,69]	5	hSpCas9	negative selection	6643797
27384325	27384348	11	+	27260156	HS294T	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.19884529795643466	[464]	[119,204,242,276]	2	hSpCas9	negative selection	6643798
27384358	27384381	11	+	27260156	HS294T	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	-0.08283068508853642	[929]	[378,358,261,354]	-1	hSpCas9	negative selection	6643799
27382177	27382200	11	+	27260156	HS294T	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.4118039084803553	[305]	[113,202,165,146]	5	hSpCas9	negative selection	6708053
27412807	27412830	11	+	27260156	HS294T	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.513244556554549	[311]	[87,80,71,98]	-6	hSpCas9	negative selection	6708054
27412783	27412806	11	+	27260156	HS294T	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.8053149228338322	[310]	[303,151,214,151]	8	hSpCas9	negative selection	6708055
27382203	27382226	11	+	27260156	HCC44	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.6186643855158397	[214]	[422,289,391,403]	8	hSpCas9	negative selection	6765048
27384325	27384348	11	+	27260156	HCC44	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.03798656391301214	[464]	[504,435,578,649]	0	hSpCas9	negative selection	6765049
27384358	27384381	11	+	27260156	HCC44	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.06674464702149452	[929]	[1363,900,1223,985]	1	hSpCas9	negative selection	6765050
27382177	27382200	11	+	27260156	HCC44	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.18352702595020842	[305]	[371,350,513,357]	3	hSpCas9	negative selection	6829304
27412807	27412830	11	+	27260156	HCC44	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.2866002417454332	[311]	[318,131,318,410]	-4	hSpCas9	negative selection	6829305
27412783	27412806	11	+	27260156	HCC44	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.5985935684865086	[310]	[555,332,857,467]	8	hSpCas9	negative selection	6829306
27382203	27382226	11	+	27260156	G402	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.6994040729103922	[214]	[557,414,262,481]	8	hSpCas9	negative selection	6886299
27384325	27384348	11	+	27260156	G402	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.39528433947673436	[464]	[712,908,878,497]	5	hSpCas9	negative selection	6886300
27384358	27384381	11	+	27260156	G402	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.16164358852631477	[929]	[953,1641,1108,1339]	2	hSpCas9	negative selection	6886301
27382177	27382200	11	+	27260156	G402	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.29563683826482723	[305]	[478,669,393,310]	3	hSpCas9	negative selection	6950555
27412807	27412830	11	+	27260156	G402	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	0.2922213398853181	[311]	[498,293,372,680]	3	hSpCas9	negative selection	6950556
27412783	27412806	11	+	27260156	G402	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.32210862957972286	[310]	[383,566,353,577]	4	hSpCas9	negative selection	6950557
27382203	27382226	11	+	27260156	L33	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.5249258306504825	[214]	[279,120,240,279]	9	hSpCas9	negative selection	7007550
27384325	27384348	11	+	27260156	L33	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.2104235706994147	[464]	[520,230,395,438]	4	hSpCas9	negative selection	7007551
27384358	27384381	11	+	27260156	L33	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.08914915627970732	[929]	[944,430,596,1010]	2	hSpCas9	negative selection	7007552
27382177	27382200	11	+	27260156	L33	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	-0.04183142242911442	[305]	[276,90,244,300]	-1	hSpCas9	negative selection	7071806
27412807	27412830	11	+	27260156	L33	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.2199539591274483	[311]	[257,117,175,245]	-5	hSpCas9	negative selection	7071807
27412783	27412806	11	+	27260156	L33	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	-0.09820834038087356	[310]	[257,122,209,270]	-2	hSpCas9	negative selection	7071808
27382203	27382226	11	+	27260156	K562	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.3117244636054054	[214]	[115,354,219,249]	4	hSpCas9	negative selection	7128801
27384325	27384348	11	+	27260156	K562	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	-0.06535594177605082	[464]	[602,301,457,242]	-1	hSpCas9	negative selection	7128802
27384358	27384381	11	+	27260156	K562	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	-0.14238637935230247	[929]	[905,1058,595,486]	-2	hSpCas9	negative selection	7128803
27382177	27382200	11	+	27260156	K562	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.1512847176793477	[305]	[343,358,371,153]	1	hSpCas9	negative selection	7193057
27412807	27412830	11	+	27260156	K562	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.20208685580886898	[311]	[179,188,343,240]	-3	hSpCas9	negative selection	7193058
27412783	27412806	11	+	27260156	K562	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.03684947046006615	[310]	[245,226,318,327]	0	hSpCas9	negative selection	7193059
27382203	27382226	11	+	27260156	HT29	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.31675827158587866	[214]	[405,310,309,282]	6	hSpCas9	negative selection	7250052
27384325	27384348	11	+	27260156	HT29	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	-0.050184540025964786	[464]	[425,647,484,611]	-1	hSpCas9	negative selection	7250053
27384358	27384381	11	+	27260156	HT29	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.26973286345506864	[929]	[1388,1303,1447,1304]	5	hSpCas9	negative selection	7250054
27382177	27382200	11	+	27260156	HT29	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.38153733029114756	[305]	[441,414,560,504]	7	hSpCas9	negative selection	7314308
27412807	27412830	11	+	27260156	HT29	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.10182659729853627	[311]	[379,459,288,299]	-2	hSpCas9	negative selection	7314309
27412783	27412806	11	+	27260156	HT29	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.3442061240046889	[310]	[593,443,449,438]	6	hSpCas9	negative selection	7314310
27382203	27382226	11	+	27260156	MHHES1	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.3317724046987477	[214]	[367,313,298,251]	6	hSpCas9	negative selection	7371303
27384325	27384348	11	+	27260156	MHHES1	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.2091414685582279	[464]	[942,449,602,468]	4	hSpCas9	negative selection	7371304
27384358	27384381	11	+	27260156	MHHES1	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.0861080613239611	[929]	[1196,1289,1177,847]	1	hSpCas9	negative selection	7371305
27382177	27382200	11	+	27260156	MHHES1	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.4232978685483819	[305]	[523,453,261,575]	7	hSpCas9	negative selection	7435559
27412807	27412830	11	+	27260156	MHHES1	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	0.12552959002924197	[311]	[450,490,290,323]	2	hSpCas9	negative selection	7435560
27412783	27412806	11	+	27260156	MHHES1	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.09304211260015482	[310]	[481,495,386,189]	1	hSpCas9	negative selection	7435561
27382203	27382226	11	+	27260156	MEWO	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.5306553414762597	[214]	[319,362,193]	9	hSpCas9	negative selection	7492554
27384325	27384348	11	+	27260156	MEWO	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	-0.1008895675129351	[464]	[516,290,430]	-2	hSpCas9	negative selection	7492555
27384358	27384381	11	+	27260156	MEWO	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	-0.05110058693700814	[929]	[1085,817,662]	-1	hSpCas9	negative selection	7492556
27382177	27382200	11	+	27260156	MEWO	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.2295482503059757	[305]	[309,319,371]	5	hSpCas9	negative selection	7556810
27412807	27412830	11	+	27260156	MEWO	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.1273351432475378	[311]	[361,268,188]	-3	hSpCas9	negative selection	7556811
27412783	27412806	11	+	27260156	MEWO	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.19692324926941995	[310]	[432,279,306]	4	hSpCas9	negative selection	7556812
27382203	27382226	11	+	27260156	LNCAPCLONEFGC	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.6658048312503334	[214]	[235,323,260,407]	9	hSpCas9	negative selection	7613805
27384325	27384348	11	+	27260156	LNCAPCLONEFGC	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.15462086071174094	[464]	[675,399,544,265]	2	hSpCas9	negative selection	7613806
27384358	27384381	11	+	27260156	LNCAPCLONEFGC	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.32665997103604694	[929]	[892,934,1355,1096]	5	hSpCas9	negative selection	7613807
27382177	27382200	11	+	27260156	LNCAPCLONEFGC	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.6753026143108543	[305]	[624,293,478,383]	9	hSpCas9	negative selection	7678061
27412807	27412830	11	+	27260156	LNCAPCLONEFGC	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.3818689922327384	[311]	[203,208,302,164]	-5	hSpCas9	negative selection	7678062
27412783	27412806	11	+	27260156	LNCAPCLONEFGC	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.05600498368668627	[310]	[284,277,289,318]	0	hSpCas9	negative selection	7678063
27382203	27382226	11	+	27260156	PANC0327	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.5095820734008008	[214]	[209,304,213,348]	7	hSpCas9	negative selection	7735056
27384325	27384348	11	+	27260156	PANC0327	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	-0.258716501776154	[464]	[506,293,412,186]	-4	hSpCas9	negative selection	7735057
27384358	27384381	11	+	27260156	PANC0327	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.33946832677301364	[929]	[1338,855,875,1157]	5	hSpCas9	negative selection	7735058
27382177	27382200	11	+	27260156	PANC0327	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	-0.4220090804178147	[305]	[162,326,96,204]	-6	hSpCas9	negative selection	7799312
27412807	27412830	11	+	27260156	PANC0327	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	0.45330218997692484	[311]	[240,214,197,872]	6	hSpCas9	negative selection	7799313
27412783	27412806	11	+	27260156	PANC0327	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.40161540592255685	[310]	[297,311,399,450]	6	hSpCas9	negative selection	7799314
27382203	27382226	11	+	27260156	NCIH2009	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.4773182308432047	[214]	[580,419,284]	6	hSpCas9	negative selection	7856307
27384325	27384348	11	+	27260156	NCIH2009	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.49418737360044596	[464]	[884,791,1062]	6	hSpCas9	negative selection	7856308
27384358	27384381	11	+	27260156	NCIH2009	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.13902249525381016	[929]	[1951,1539,898]	2	hSpCas9	negative selection	7856309
27382177	27382200	11	+	27260156	NCIH2009	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.44027743105264183	[305]	[620,491,635]	6	hSpCas9	negative selection	7920563
27412807	27412830	11	+	27260156	NCIH2009	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	0.023157597536362373	[311]	[437,396,492]	0	hSpCas9	negative selection	7920564
27412783	27412806	11	+	27260156	NCIH2009	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.04651185608824948	[310]	[546,388,429]	0	hSpCas9	negative selection	7920565
27382203	27382226	11	+	27260156	NCIH1373	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	1.2835229785605555	[214]	[328,1062,359,130]	9	hSpCas9	negative selection	7977558
27384325	27384348	11	+	27260156	NCIH1373	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.9116688698088178	[464]	[1813,665,787,211]	8	hSpCas9	negative selection	7977559
27384358	27384381	11	+	27260156	NCIH1373	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.3256529195446214	[929]	[2161,1379,1167,155]	3	hSpCas9	negative selection	7977560
27382177	27382200	11	+	27260156	NCIH1373	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.2599786874205277	[305]	[535,357,487,71]	2	hSpCas9	negative selection	8041814
27412807	27412830	11	+	27260156	NCIH1373	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.12031047519319304	[311]	[382,292,221,106]	-1	hSpCas9	negative selection	8041815
27412783	27412806	11	+	27260156	NCIH1373	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.37011187284446173	[310]	[761,330,384,99]	3	hSpCas9	negative selection	8041816
27382203	27382226	11	+	27260156	PATU8902	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.8151312688188123	[214]	[390,804,415,521]	8	hSpCas9	negative selection	8098809
27384325	27384348	11	+	27260156	PATU8902	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.469831909122324	[464]	[750,976,914,939]	5	hSpCas9	negative selection	8098810
27384358	27384381	11	+	27260156	PATU8902	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.27539795764056807	[929]	[1421,1982,1138,1863]	3	hSpCas9	negative selection	8098811
27382177	27382200	11	+	27260156	PATU8902	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.8568806732240096	[305]	[516,749,770,1083]	8	hSpCas9	negative selection	8163065
27412807	27412830	11	+	27260156	PATU8902	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	0.4621448096891463	[311]	[684,350,439,1000]	5	hSpCas9	negative selection	8163066
27412783	27412806	11	+	27260156	PATU8902	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.3978690948127202	[310]	[565,627,200,1034]	4	hSpCas9	negative selection	8163067
27382203	27382226	11	+	27260156	PANC1	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.5935283204398158	[214]	[199,360,231,326]	8	hSpCas9	negative selection	8220060
27384325	27384348	11	+	27260156	PANC1	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.42667759489145096	[464]	[473,543,483,623]	7	hSpCas9	negative selection	8220061
27384358	27384381	11	+	27260156	PANC1	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.28348197269508435	[929]	[978,1201,1016,757]	4	hSpCas9	negative selection	8220062
27382177	27382200	11	+	27260156	PANC1	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.306440710848044	[305]	[265,368,383,291]	5	hSpCas9	negative selection	8284316
27412807	27412830	11	+	27260156	PANC1	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.45989379757487747	[311]	[240,205,89,232]	-6	hSpCas9	negative selection	8284317
27412783	27412806	11	+	27260156	PANC1	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.31741976966119606	[310]	[376,501,178,304]	5	hSpCas9	negative selection	8284318
27382203	27382226	11	+	27260156	PANC0813	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.9404631444371874	[214]	[515,314,512,590]	9	hSpCas9	negative selection	8341311
27384325	27384348	11	+	27260156	PANC0813	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.37325367618767646	[464]	[655,922,672,578]	6	hSpCas9	negative selection	8341312
27384358	27384381	11	+	27260156	PANC0813	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.2799162017721004	[929]	[1281,1553,1067,1389]	4	hSpCas9	negative selection	8341313
27382177	27382200	11	+	27260156	PANC0813	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.189297861994011	[305]	[504,344,294,496]	3	hSpCas9	negative selection	8405567
27412807	27412830	11	+	27260156	PANC0813	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	0.11286168516139367	[311]	[515,316,373,388]	1	hSpCas9	negative selection	8405568
27412783	27412806	11	+	27260156	PANC0813	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	-0.025864732066876783	[310]	[265,460,460,244]	0	hSpCas9	negative selection	8405569
27382203	27382226	11	+	27260156	RDES	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.7065090494113719	[214]	[443,394,388,354]	9	hSpCas9	negative selection	8462562
27384325	27384348	11	+	27260156	RDES	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.1511204500994503	[464]	[479,551,608,772]	2	hSpCas9	negative selection	8462563
27384358	27384381	11	+	27260156	RDES	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.20297237447957994	[929]	[1020,1146,1356,1453]	3	hSpCas9	negative selection	8462564
27382177	27382200	11	+	27260156	RDES	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.31997202471361513	[305]	[366,440,445,516]	5	hSpCas9	negative selection	8526818
27412807	27412830	11	+	27260156	RDES	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	0.07052494030000322	[311]	[295,380,366,484]	1	hSpCas9	negative selection	8526819
27412783	27412806	11	+	27260156	RDES	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.6206198896133297	[310]	[382,693,457,687]	8	hSpCas9	negative selection	8526820
27382203	27382226	11	+	27260156	PC3	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.3100806757564999	[214]	[218,272,275,285]	6	hSpCas9	negative selection	8583813
27384325	27384348	11	+	27260156	PC3	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.042914528046864124	[464]	[257,521,685,581]	1	hSpCas9	negative selection	8583814
27384358	27384381	11	+	27260156	PC3	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	-0.020204241575172865	[929]	[566,975,1434,941]	0	hSpCas9	negative selection	8583815
27382177	27382200	11	+	27260156	PC3	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.009074877693376449	[305]	[196,411,403,260]	0	hSpCas9	negative selection	8648069
27412807	27412830	11	+	27260156	PC3	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.0811105162582868	[311]	[162,377,422,287]	-2	hSpCas9	negative selection	8648070
27412783	27412806	11	+	27260156	PC3	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.3864775777897293	[310]	[191,449,777,405]	7	hSpCas9	negative selection	8648071
27382203	27382226	11	+	27260156	PATU8988T	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.9131122677835247	[214]	[182,201,275,930]	9	hSpCas9	negative selection	8705064
27384325	27384348	11	+	27260156	PATU8988T	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	-0.0028363035534106837	[464]	[651,249,497,367]	0	hSpCas9	negative selection	8705065
27384358	27384381	11	+	27260156	PATU8988T	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.07730151493729043	[929]	[1116,1087,533,1082]	1	hSpCas9	negative selection	8705066
27382177	27382200	11	+	27260156	PATU8988T	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.2943309549435772	[305]	[302,355,239,568]	5	hSpCas9	negative selection	8769320
27412807	27412830	11	+	27260156	PATU8988T	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.02743891091723427	[311]	[382,304,243,248]	0	hSpCas9	negative selection	8769321
27412783	27412806	11	+	27260156	PATU8988T	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	-0.1229950846357939	[310]	[232,316,286,269]	-2	hSpCas9	negative selection	8769322
27382203	27382226	11	+	27260156	T47D	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.31732267775256195	[214]	[250,298,283,418]	6	hSpCas9	negative selection	8826315
27384325	27384348	11	+	27260156	T47D	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.08262072328398389	[464]	[615,511,588,582]	1	hSpCas9	negative selection	8826316
27384358	27384381	11	+	27260156	T47D	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.14152963896729087	[929]	[1081,1143,1266,1292]	3	hSpCas9	negative selection	8826317
27382177	27382200	11	+	27260156	T47D	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.26399366227875226	[305]	[401,368,450,496]	5	hSpCas9	negative selection	8890571
27412807	27412830	11	+	27260156	T47D	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.1450769694216486	[311]	[298,306,332,378]	-3	hSpCas9	negative selection	8890572
27412783	27412806	11	+	27260156	T47D	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.2109125287185606	[310]	[488,353,424,414]	4	hSpCas9	negative selection	8890573
27382203	27382226	11	+	27260156	SU8686	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	1.0460065007000021	[214]	[318,486,453,517]	9	hSpCas9	negative selection	8947566
27384325	27384348	11	+	27260156	SU8686	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.4081144402327056	[464]	[727,516,562,635]	7	hSpCas9	negative selection	8947567
27384358	27384381	11	+	27260156	SU8686	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.24119530785280485	[929]	[1090,906,1114,1295]	4	hSpCas9	negative selection	8947568
27382177	27382200	11	+	27260156	SU8686	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.18284944958187083	[305]	[386,287,331,374]	3	hSpCas9	negative selection	9011822
27412807	27412830	11	+	27260156	SU8686	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	0.19905174250102398	[311]	[274,216,435,550]	3	hSpCas9	negative selection	9011823
27412783	27412806	11	+	27260156	SU8686	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	-0.059670981986409966	[310]	[339,193,343,315]	-1	hSpCas9	negative selection	9011824
27382203	27382226	11	+	27260156	SKES1	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.648464533277635	[214]	[369,412,336,245]	9	hSpCas9	negative selection	9068817
27384325	27384348	11	+	27260156	SKES1	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.09416910240385308	[464]	[704,560,362,396]	2	hSpCas9	negative selection	9068818
27384358	27384381	11	+	27260156	SKES1	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.05737476341319847	[929]	[1095,1016,906,867]	1	hSpCas9	negative selection	9068819
27382177	27382200	11	+	27260156	SKES1	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.2747241814961233	[305]	[186,448,436,381]	6	hSpCas9	negative selection	9133073
27412807	27412830	11	+	27260156	SKES1	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.4603198166162178	[311]	[229,293,213,178]	-7	hSpCas9	negative selection	9133074
27412783	27412806	11	+	27260156	SKES1	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.3786691381306242	[310]	[354,399,448,397]	7	hSpCas9	negative selection	9133075
27382203	27382226	11	+	27260156	TOV112D	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.6293602744585678	[214]	[530,303,269,238]	9	hSpCas9	negative selection	9190068
27384325	27384348	11	+	27260156	TOV112D	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	-0.1647200321571111	[464]	[326,451,332,546]	-3	hSpCas9	negative selection	9190069
27384358	27384381	11	+	27260156	TOV112D	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.3171363293670746	[929]	[818,1828,1270,864]	6	hSpCas9	negative selection	9190070
27382177	27382200	11	+	27260156	TOV112D	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.3631549196740557	[305]	[355,486,330,420]	6	hSpCas9	negative selection	9254324
27412807	27412830	11	+	27260156	TOV112D	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	0.23695548203128108	[311]	[292,525,392,294]	4	hSpCas9	negative selection	9254325
27412783	27412806	11	+	27260156	TOV112D	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.3363077174353152	[310]	[409,334,477,337]	6	hSpCas9	negative selection	9254326
27382203	27382226	11	+	27260156	TC71	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.3250336665116881	[214]	[294,245,288,326]	7	hSpCas9	negative selection	9311319
27384325	27384348	11	+	27260156	TC71	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	0.2167690192405893	[464]	[631,494,487,711]	5	hSpCas9	negative selection	9311320
27384358	27384381	11	+	27260156	TC71	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.09343950128800094	[929]	[996,1012,1009,1248]	2	hSpCas9	negative selection	9311321
27382177	27382200	11	+	27260156	TC71	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	0.06265748367132284	[305]	[304,343,317,408]	1	hSpCas9	negative selection	9375575
27412807	27412830	11	+	27260156	TC71	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.3257313363608828	[311]	[242,252,280,291]	-7	hSpCas9	negative selection	9375576
27412783	27412806	11	+	27260156	TC71	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.09104188780530564	[310]	[367,361,391,292]	2	hSpCas9	negative selection	9375577
27382203	27382226	11	+	27260156	TC32	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.30881200647743556	[214]	[239,187,347,251]	5	hSpCas9	negative selection	9432570
27384325	27384348	11	+	27260156	TC32	viability	AATATACTTACAAGGTCTCCAGG	LGR4	ENSG00000205213	-0.1352308238620623	[464]	[365,226,595,488]	-2	hSpCas9	negative selection	9432571
27384358	27384381	11	+	27260156	TC32	viability	CATCAAAACAGTGTTGACTCAGG	LGR4	ENSG00000205213	0.04928007256533595	[929]	[819,568,1398,1007]	0	hSpCas9	negative selection	9432572
27382177	27382200	11	+	27260156	TC32	viability	GCAATACTCACAGCTCTTTAAGG	LGR4	ENSG00000205213	-0.03840313618659874	[305]	[318,150,424,277]	0	hSpCas9	negative selection	9496826
27412807	27412830	11	+	27260156	TC32	viability	AAGTTCTTAAATGCATCTTCTGG	LGR4	ENSG00000205213	-0.24530583287836594	[311]	[253,202,326,217]	-4	hSpCas9	negative selection	9496827
27412783	27412806	11	+	27260156	TC32	viability	ACTTACAGCTCTTCTAGAAAAGG	LGR4	ENSG00000205213	0.18661268567056688	[310]	[306,239,329,479]	3	hSpCas9	negative selection	9496828
27367890	27367913	11	+	27869803	HPAFII	viability after 27 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	0.5247323641047736	[299]	[299,165,NaN]	4	hSpCas9	negative selection	9541104
27373628	27373651	11	+	27869803	HPAFII	viability after 27 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	0.6243397261468897	[128]	[127,84,NaN]	5	hSpCas9	negative selection	9541105
27380317	27380340	11	-	27869803	HPAFII	viability after 27 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	0.4493716287077779	[289]	[295,134,NaN]	3	hSpCas9	negative selection	9541106
27382186	27382209	11	+	27869803	HPAFII	viability after 27 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.4436957920138672	[118]	[89,80,NaN]	3	hSpCas9	negative selection	9541107
27385317	27385340	11	-	27869803	HPAFII	viability after 27 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	0.3393435649568758	[400]	[305,233,NaN]	2	hSpCas9	negative selection	9541108
27367890	27367913	11	+	27869803	HPAFII	viability after 15 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	0.402867694066688	[299]	[749,224,NaN]	4	hSpCas9	negative selection	9623553
27373628	27373651	11	+	27869803	HPAFII	viability after 15 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	1.057817800877892	[128]	[480,168,NaN]	9	hSpCas9	negative selection	9623554
27380317	27380340	11	-	27869803	HPAFII	viability after 15 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	0.32503424664237923	[289]	[522,307,NaN]	4	hSpCas9	negative selection	9623555
27382186	27382209	11	+	27869803	HPAFII	viability after 15 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	-0.6615562790487091	[118]	[115,58,NaN]	-6	hSpCas9	negative selection	9623556
27385317	27385340	11	-	27869803	HPAFII	viability after 15 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	0.4972324631129693	[400]	[722,536,NaN]	6	hSpCas9	negative selection	9623557
27367890	27367913	11	+	27869803	ASPC1	viability after 36 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	0.13515787734273266	[740]	[248,391,219]	1	hSpCas9	negative selection	9706002
27373628	27373651	11	+	27869803	ASPC1	viability after 36 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	0.4574309774891988	[273]	[94,146,142]	4	hSpCas9	negative selection	9706003
27380317	27380340	11	-	27869803	ASPC1	viability after 36 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	0.09865198627977823	[1075]	[603,88,504]	1	hSpCas9	negative selection	9706004
27382186	27382209	11	+	27869803	ASPC1	viability after 36 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	-0.860564619567521	[276]	[50,40,63]	-7	hSpCas9	negative selection	9706005
27385317	27385340	11	-	27869803	ASPC1	viability after 36 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	1.3578809813954986	[1305]	[1335,1254,969]	9	hSpCas9	negative selection	9706006
27367890	27367913	11	+	27869803	PATU8988S	viability after 35 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	0.47088613540447244	[645]	[401,318,NaN]	5	hSpCas9	negative selection	9788451
27373628	27373651	11	+	27869803	PATU8988S	viability after 35 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	-0.3052431609957271	[306]	[128,70,NaN]	-3	hSpCas9	negative selection	9788452
27380317	27380340	11	-	27869803	PATU8988S	viability after 35 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	0.5837582141087432	[777]	[301,637,NaN]	6	hSpCas9	negative selection	9788453
27382186	27382209	11	+	27869803	PATU8988S	viability after 35 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	1.0983719243893562	[281]	[102,383,NaN]	9	hSpCas9	negative selection	9788454
27385317	27385340	11	-	27869803	PATU8988S	viability after 35 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	-0.19554451415916563	[1146]	[358,447,NaN]	-2	hSpCas9	negative selection	9788455
27367890	27367913	11	+	27869803	PATU8988S	viability after 31 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	0.5141675606486726	[645]	[366,368,NaN]	6	hSpCas9	negative selection	9870900
27373628	27373651	11	+	27869803	PATU8988S	viability after 31 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	-0.38529094445023393	[306]	[109,72,NaN]	-4	hSpCas9	negative selection	9870901
27380317	27380340	11	-	27869803	PATU8988S	viability after 31 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	0.552347867578044	[777]	[318,627,NaN]	6	hSpCas9	negative selection	9870902
27382186	27382209	11	+	27869803	PATU8988S	viability after 31 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.6605525697765409	[281]	[87,291,NaN]	7	hSpCas9	negative selection	9870903
27385317	27385340	11	-	27869803	PATU8988S	viability after 31 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	-0.47053316567267056	[1146]	[304,361,NaN]	-5	hSpCas9	negative selection	9870904
27367890	27367913	11	+	27869803	HPAFII	viability after 35 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	0.9646291741490409	[299]	[373,208,NaN]	6	hSpCas9	negative selection	9953349
27373628	27373651	11	+	27869803	HPAFII	viability after 35 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	-0.424354760792679	[128]	[82,9,NaN]	-3	hSpCas9	negative selection	9953350
27380317	27380340	11	-	27869803	HPAFII	viability after 35 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	0.8866832731380113	[289]	[333,200,NaN]	6	hSpCas9	negative selection	9953351
27382186	27382209	11	+	27869803	HPAFII	viability after 35 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.8460601776788294	[118]	[104,111,NaN]	5	hSpCas9	negative selection	9953352
27385317	27385340	11	-	27869803	HPAFII	viability after 35 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	0.1900280047038957	[400]	[224,238,NaN]	1	hSpCas9	negative selection	9953353
27367890	27367913	11	+	27869803	HPAFII	viability after 31 days	TGTAAGCATAGCGCACCAAAGGG	LGR4	ENSG00000205213	0.5986230369205737	[299]	[331,170,NaN]	4	hSpCas9	negative selection	10035798
27373628	27373651	11	+	27869803	HPAFII	viability after 31 days	ATTCAGGCCTTCCGTAGGAAAGG	LGR4	ENSG00000205213	0.2833310224945226	[128]	[123,48,NaN]	2	hSpCas9	negative selection	10035799
27380317	27380340	11	-	27869803	HPAFII	viability after 31 days	AGTCATTCGTGGTGCAAGCATGG	LGR4	ENSG00000205213	0.6729734141396908	[289]	[247,271,NaN]	5	hSpCas9	negative selection	10035800
27382186	27382209	11	+	27869803	HPAFII	viability after 31 days	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.8396789231954023	[118]	[119,118,NaN]	6	hSpCas9	negative selection	10035801
27385317	27385340	11	-	27869803	HPAFII	viability after 31 days	CACCCTACAGGCGCTGACCCTGG	LGR4	ENSG00000205213	0.4104657782901139	[400]	[256,344,NaN]	3	hSpCas9	negative selection	10035802
27385368	27385391	11	-	28162770	P31FUJ	viability	GGATGACAACAGCTTGACGGAGG	LGR4	ENSG00000205213	-0.7143351154801292	[147]	[105]	-5	hSpCas9	negative selection	10184180
27385332	27385355	11	+	28162770	P31FUJ	viability	GTAGGGTGGGCAGATTGCTGAGG	LGR4	ENSG00000205213	-1.7422419284088444	[520]	[182]	-8	hSpCas9	negative selection	10184181
27380673	27380696	11	+	28162770	P31FUJ	viability	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	0.28641733327174473	[216]	[310]	3	hSpCas9	negative selection	10184182
27385272	27385295	11	+	28162770	P31FUJ	viability	GGTTGGTAAATGCAAAGTCAGGG	LGR4	ENSG00000205213	0.39247775149426567	[493]	[761]	4	hSpCas9	negative selection	10184183
27382203	27382226	11	+	28162770	P31FUJ	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	-3.554730299301741	[9]	[0]	-9	hSpCas9	negative selection	10184184
27392455	27392478	11	+	28162770	P31FUJ	viability	GAGTTCTTTCAACCCAGACAAGG	LGR4	ENSG00000205213	0.1466911780067981	[338]	[440]	1	hSpCas9	negative selection	10184185
27382186	27382209	11	+	28162770	P31FUJ	viability	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.7691890934047128	[361]	[724]	8	hSpCas9	negative selection	10184186
27385368	27385391	11	-	28162770	TF1	viability	GGATGACAACAGCTTGACGGAGG	LGR4	ENSG00000205213	NaN	[NaN]	[128]	1	hSpCas9	negative selection	10353546
27385332	27385355	11	+	28162770	TF1	viability	GTAGGGTGGGCAGATTGCTGAGG	LGR4	ENSG00000205213	NaN	[NaN]	[96]	1	hSpCas9	negative selection	10353547
27380673	27380696	11	+	28162770	TF1	viability	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	NaN	[NaN]	[378]	1	hSpCas9	negative selection	10353548
27385272	27385295	11	+	28162770	TF1	viability	GGTTGGTAAATGCAAAGTCAGGG	LGR4	ENSG00000205213	NaN	[NaN]	[456]	1	hSpCas9	negative selection	10353549
27382203	27382226	11	+	28162770	TF1	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	NaN	[NaN]	[0]	1	hSpCas9	negative selection	10353550
27392455	27392478	11	+	28162770	TF1	viability	GAGTTCTTTCAACCCAGACAAGG	LGR4	ENSG00000205213	NaN	[NaN]	[457]	1	hSpCas9	negative selection	10353551
27382186	27382209	11	+	28162770	TF1	viability	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	NaN	[NaN]	[410]	1	hSpCas9	negative selection	10353552
27385368	27385391	11	-	28162770	SKM1	viability	GGATGACAACAGCTTGACGGAGG	LGR4	ENSG00000205213	0.14628944225065632	[45]	[89]	1	hSpCas9	negative selection	10522912
27385332	27385355	11	+	28162770	SKM1	viability	GTAGGGTGGGCAGATTGCTGAGG	LGR4	ENSG00000205213	-0.9654932916115381	[168]	[152]	-6	hSpCas9	negative selection	10522913
27380673	27380696	11	+	28162770	SKM1	viability	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	0.6727629937275725	[65]	[185]	6	hSpCas9	negative selection	10522914
27385272	27385295	11	+	28162770	SKM1	viability	GGTTGGTAAATGCAAAGTCAGGG	LGR4	ENSG00000205213	0.8969781506708381	[112]	[371]	8	hSpCas9	negative selection	10522915
27382203	27382226	11	+	28162770	SKM1	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	-1.8220016980220048	[1]	[0]	-8	hSpCas9	negative selection	10522916
27392455	27392478	11	+	28162770	SKM1	viability	GAGTTCTTTCAACCCAGACAAGG	LGR4	ENSG00000205213	1.4016025629832507	[84]	[396]	9	hSpCas9	negative selection	10522917
27382186	27382209	11	+	28162770	SKM1	viability	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	-0.20184976883854944	[107]	[165]	-2	hSpCas9	negative selection	10522918
27385368	27385391	11	-	28162770	SKM1	viability	GGATGACAACAGCTTGACGGAGG	LGR4	ENSG00000205213	0.14628944225065632	[45]	[89]	1	hSpCas9	negative selection	10692278
27385332	27385355	11	+	28162770	SKM1	viability	GTAGGGTGGGCAGATTGCTGAGG	LGR4	ENSG00000205213	-0.9654932916115381	[168]	[152]	-6	hSpCas9	negative selection	10692279
27380673	27380696	11	+	28162770	SKM1	viability	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	0.6727629937275725	[65]	[185]	6	hSpCas9	negative selection	10692280
27385272	27385295	11	+	28162770	SKM1	viability	GGTTGGTAAATGCAAAGTCAGGG	LGR4	ENSG00000205213	0.8969781506708381	[112]	[371]	8	hSpCas9	negative selection	10692281
27382203	27382226	11	+	28162770	SKM1	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	-1.8220016980220048	[1]	[0]	-8	hSpCas9	negative selection	10692282
27392455	27392478	11	+	28162770	SKM1	viability	GAGTTCTTTCAACCCAGACAAGG	LGR4	ENSG00000205213	1.4016025629832507	[84]	[396]	9	hSpCas9	negative selection	10692283
27382186	27382209	11	+	28162770	SKM1	viability	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	-0.20184976883854944	[107]	[165]	-2	hSpCas9	negative selection	10692284
27385368	27385391	11	-	28162770	PL21	viability	GGATGACAACAGCTTGACGGAGG	LGR4	ENSG00000205213	0.1261390330455434	[199]	[94]	1	hSpCas9	negative selection	10861644
27385332	27385355	11	+	28162770	PL21	viability	GTAGGGTGGGCAGATTGCTGAGG	LGR4	ENSG00000205213	-0.3848228862318359	[473]	[157]	-3	hSpCas9	negative selection	10861645
27380673	27380696	11	+	28162770	PL21	viability	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	0.7692771480487937	[274]	[203]	6	hSpCas9	negative selection	10861646
27385272	27385295	11	+	28162770	PL21	viability	GGTTGGTAAATGCAAAGTCAGGG	LGR4	ENSG00000205213	-0.024177683771620107	[499]	[213]	0	hSpCas9	negative selection	10861647
27382203	27382226	11	+	28162770	PL21	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	-1.1217884803980427	[4]	[0]	-6	hSpCas9	negative selection	10861648
27392455	27392478	11	+	28162770	PL21	viability	GAGTTCTTTCAACCCAGACAAGG	LGR4	ENSG00000205213	1.252395851620744	[243]	[252]	8	hSpCas9	negative selection	10861649
27382186	27382209	11	+	28162770	PL21	viability	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.3749140155930283	[263]	[148]	3	hSpCas9	negative selection	10861650
27385368	27385391	11	-	28162770	P31FUJ	viability	GGATGACAACAGCTTGACGGAGG	LGR4	ENSG00000205213	-0.7143351154801292	[147]	[105]	-5	hSpCas9	negative selection	11031010
27385332	27385355	11	+	28162770	P31FUJ	viability	GTAGGGTGGGCAGATTGCTGAGG	LGR4	ENSG00000205213	-1.7422419284088444	[520]	[182]	-8	hSpCas9	negative selection	11031011
27380673	27380696	11	+	28162770	P31FUJ	viability	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	0.28641733327174473	[216]	[310]	3	hSpCas9	negative selection	11031012
27385272	27385295	11	+	28162770	P31FUJ	viability	GGTTGGTAAATGCAAAGTCAGGG	LGR4	ENSG00000205213	0.39247775149426567	[493]	[761]	4	hSpCas9	negative selection	11031013
27382203	27382226	11	+	28162770	P31FUJ	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	-3.554730299301741	[9]	[0]	-9	hSpCas9	negative selection	11031014
27392455	27392478	11	+	28162770	P31FUJ	viability	GAGTTCTTTCAACCCAGACAAGG	LGR4	ENSG00000205213	0.1466911780067981	[338]	[440]	1	hSpCas9	negative selection	11031015
27382186	27382209	11	+	28162770	P31FUJ	viability	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.7691890934047128	[361]	[724]	8	hSpCas9	negative selection	11031016
27385368	27385391	11	-	28162770	OCIAML5	viability	GGATGACAACAGCTTGACGGAGG	LGR4	ENSG00000205213	0.9502527612963088	[81]	[285]	8	hSpCas9	negative selection	11200376
27385332	27385355	11	+	28162770	OCIAML5	viability	GTAGGGTGGGCAGATTGCTGAGG	LGR4	ENSG00000205213	-1.4782517343116663	[212]	[137]	-7	hSpCas9	negative selection	11200377
27380673	27380696	11	+	28162770	OCIAML5	viability	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	0.6557280693346994	[159]	[454]	6	hSpCas9	negative selection	11200378
27385272	27385295	11	+	28162770	OCIAML5	viability	GGTTGGTAAATGCAAAGTCAGGG	LGR4	ENSG00000205213	0.3608271909222045	[282]	[655]	3	hSpCas9	negative selection	11200379
27382203	27382226	11	+	28162770	OCIAML5	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	-0.8520665708639967	[0]	[0]	-5	hSpCas9	negative selection	11200380
27392455	27392478	11	+	28162770	OCIAML5	viability	GAGTTCTTTCAACCCAGACAAGG	LGR4	ENSG00000205213	1.692818490481824	[145]	[851]	9	hSpCas9	negative selection	11200381
27382186	27382209	11	+	28162770	OCIAML5	viability	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.5514490585196273	[219]	[581]	5	hSpCas9	negative selection	11200382
27385368	27385391	11	-	28162770	EOL1	viability	GGATGACAACAGCTTGACGGAGG	LGR4	ENSG00000205213	0.7856245051694745	[304]	[276]	7	hSpCas9	negative selection	11369742
27385332	27385355	11	+	28162770	EOL1	viability	GTAGGGTGGGCAGATTGCTGAGG	LGR4	ENSG00000205213	-0.6776551792394532	[925]	[304]	-5	hSpCas9	negative selection	11369743
27380673	27380696	11	+	28162770	EOL1	viability	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	1.0611423201517534	[432]	[475]	8	hSpCas9	negative selection	11369744
27385272	27385295	11	+	28162770	EOL1	viability	GGTTGGTAAATGCAAAGTCAGGG	LGR4	ENSG00000205213	1.2648879035717773	[762]	[965]	9	hSpCas9	negative selection	11369745
27382203	27382226	11	+	28162770	EOL1	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	0.924547771570535	[0]	[0]	7	hSpCas9	negative selection	11369746
27392455	27392478	11	+	28162770	EOL1	viability	GAGTTCTTTCAACCCAGACAAGG	LGR4	ENSG00000205213	-0.6901620725446738	[342]	[111]	-5	hSpCas9	negative selection	11369747
27382186	27382209	11	+	28162770	EOL1	viability	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.31043892518986205	[374]	[244]	3	hSpCas9	negative selection	11369748
27385368	27385391	11	-	28162770	MOLM13	viability	GGATGACAACAGCTTGACGGAGG	LGR4	ENSG00000205213	0.68536631246691	[251]	[292]	5	hSpCas9	negative selection	11539108
27385332	27385355	11	+	28162770	MOLM13	viability	GTAGGGTGGGCAGATTGCTGAGG	LGR4	ENSG00000205213	-2.100248496535219	[681]	[114]	-7	hSpCas9	negative selection	11539109
27380673	27380696	11	+	28162770	MOLM13	viability	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	1.9791421960827258	[260]	[743]	9	hSpCas9	negative selection	11539110
27385272	27385295	11	+	28162770	MOLM13	viability	GGTTGGTAAATGCAAAGTCAGGG	LGR4	ENSG00000205213	0.8111415705110903	[684]	[868]	6	hSpCas9	negative selection	11539111
27382203	27382226	11	+	28162770	MOLM13	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	1.747997300737314	[6]	[16]	9	hSpCas9	negative selection	11539112
27392455	27392478	11	+	28162770	MOLM13	viability	GAGTTCTTTCAACCCAGACAAGG	LGR4	ENSG00000205213	0.06382300008673808	[392]	[296]	0	hSpCas9	negative selection	11539113
27382186	27382209	11	+	28162770	MOLM13	viability	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.22783829371162423	[410]	[347]	1	hSpCas9	negative selection	11539114
27385368	27385391	11	-	28162770	HEL	viability	GGATGACAACAGCTTGACGGAGG	LGR4	ENSG00000205213	-0.32656437077672656	[185]	[94]	-2	hSpCas9	negative selection	11708474
27385332	27385355	11	+	28162770	HEL	viability	GTAGGGTGGGCAGATTGCTGAGG	LGR4	ENSG00000205213	-2.4787246804853105	[643]	[73]	-8	hSpCas9	negative selection	11708475
27380673	27380696	11	+	28162770	HEL	viability	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	0.46247188633658554	[314]	[277]	4	hSpCas9	negative selection	11708476
27385272	27385295	11	+	28162770	HEL	viability	GGTTGGTAAATGCAAAGTCAGGG	LGR4	ENSG00000205213	0.5523923299041031	[625]	[587]	4	hSpCas9	negative selection	11708477
27382203	27382226	11	+	28162770	HEL	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	-1.942223668720799	[5]	[0]	-8	hSpCas9	negative selection	11708478
27392455	27392478	11	+	28162770	HEL	viability	GAGTTCTTTCAACCCAGACAAGG	LGR4	ENSG00000205213	0.15115977784852003	[328]	[233]	1	hSpCas9	negative selection	11708479
27382186	27382209	11	+	28162770	HEL	viability	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.35278312685127433	[356]	[291]	3	hSpCas9	negative selection	11708480
27385368	27385391	11	-	28162770	MV411	viability	GGATGACAACAGCTTGACGGAGG	LGR4	ENSG00000205213	0.29129184037220274	[161]	[166]	2	hSpCas9	negative selection	11877840
27385332	27385355	11	+	28162770	MV411	viability	GTAGGGTGGGCAGATTGCTGAGG	LGR4	ENSG00000205213	-1.6426848314448512	[555]	[149]	-7	hSpCas9	negative selection	11877841
27380673	27380696	11	+	28162770	MV411	viability	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	0.5834867539147905	[243]	[307]	5	hSpCas9	negative selection	11877842
27385272	27385295	11	+	28162770	MV411	viability	GGTTGGTAAATGCAAAGTCAGGG	LGR4	ENSG00000205213	0.33677578124325325	[406]	[432]	3	hSpCas9	negative selection	11877843
27382203	27382226	11	+	28162770	MV411	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	1.5369441679777598	[8]	[21]	9	hSpCas9	negative selection	11877844
27392455	27392478	11	+	28162770	MV411	viability	GAGTTCTTTCAACCCAGACAAGG	LGR4	ENSG00000205213	-0.016720012009955987	[256]	[213]	0	hSpCas9	negative selection	11877845
27382186	27382209	11	+	28162770	MV411	viability	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.0698993652305876	[284]	[251]	0	hSpCas9	negative selection	11877846
27385368	27385391	11	-	28162770	MONOMAC1	viability	GGATGACAACAGCTTGACGGAGG	LGR4	ENSG00000205213	0.2633805557232992	[132]	[182]	2	hSpCas9	negative selection	12047206
27385332	27385355	11	+	28162770	MONOMAC1	viability	GTAGGGTGGGCAGATTGCTGAGG	LGR4	ENSG00000205213	-1.3765862673902665	[375]	[165]	-8	hSpCas9	negative selection	12047207
27380673	27380696	11	+	28162770	MONOMAC1	viability	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	0.6603587574976459	[169]	[307]	6	hSpCas9	negative selection	12047208
27385272	27385295	11	+	28162770	MONOMAC1	viability	GGTTGGTAAATGCAAAGTCAGGG	LGR4	ENSG00000205213	0.32060262881798796	[328]	[470]	3	hSpCas9	negative selection	12047209
27382203	27382226	11	+	28162770	MONOMAC1	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	-0.19703684705955382	[0]	[0]	-2	hSpCas9	negative selection	12047210
27392455	27392478	11	+	28162770	MONOMAC1	viability	GAGTTCTTTCAACCCAGACAAGG	LGR4	ENSG00000205213	-0.01519852407374056	[200]	[227]	0	hSpCas9	negative selection	12047211
27382186	27382209	11	+	28162770	MONOMAC1	viability	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.5578506551039147	[175]	[296]	5	hSpCas9	negative selection	12047212
27385368	27385391	11	-	28162770	OCIAML2	viability	GGATGACAACAGCTTGACGGAGG	LGR4	ENSG00000205213	-0.36371462132564925	[38]	[167]	-3	hSpCas9	negative selection	12216572
27385332	27385355	11	+	28162770	OCIAML2	viability	GTAGGGTGGGCAGATTGCTGAGG	LGR4	ENSG00000205213	-2.03005723385618	[97]	[132]	-8	hSpCas9	negative selection	12216573
27380673	27380696	11	+	28162770	OCIAML2	viability	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	0.41038213854075184	[29]	[220]	4	hSpCas9	negative selection	12216574
27385272	27385295	11	+	28162770	OCIAML2	viability	GGTTGGTAAATGCAAAGTCAGGG	LGR4	ENSG00000205213	-0.0585039213832208	[123]	[659]	0	hSpCas9	negative selection	12216575
27382203	27382226	11	+	28162770	OCIAML2	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	-2.4706298252421615	[0]	[0]	-8	hSpCas9	negative selection	12216576
27392455	27392478	11	+	28162770	OCIAML2	viability	GAGTTCTTTCAACCCAGACAAGG	LGR4	ENSG00000205213	0.48743949429192046	[47]	[372]	5	hSpCas9	negative selection	12216577
27382186	27382209	11	+	28162770	OCIAML2	viability	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	0.6513606991364491	[50]	[443]	6	hSpCas9	negative selection	12216578
27385368	27385391	11	-	28162770	OCIAML3	viability	GGATGACAACAGCTTGACGGAGG	LGR4	ENSG00000205213	-0.8511654798212878	[48]	[81]	-6	hSpCas9	negative selection	12385938
27385332	27385355	11	+	28162770	OCIAML3	viability	GTAGGGTGGGCAGATTGCTGAGG	LGR4	ENSG00000205213	-0.920988962937811	[142]	[227]	-6	hSpCas9	negative selection	12385939
27380673	27380696	11	+	28162770	OCIAML3	viability	GAGTTCCCCACAAAAGACAGAGG	LGR4	ENSG00000205213	1.7465018803049248	[53]	[546]	9	hSpCas9	negative selection	12385940
27385272	27385295	11	+	28162770	OCIAML3	viability	GGTTGGTAAATGCAAAGTCAGGG	LGR4	ENSG00000205213	0.410793345939658	[149]	[601]	4	hSpCas9	negative selection	12385941
27382203	27382226	11	+	28162770	OCIAML3	viability	GGAAGGGCTTTAATAGCCTGAGG	LGR4	ENSG00000205213	-1.594007640324163	[1]	[1]	-8	hSpCas9	negative selection	12385942
27392455	27392478	11	+	28162770	OCIAML3	viability	GAGTTCTTTCAACCCAGACAAGG	LGR4	ENSG00000205213	1.0580690562555297	[41]	[263]	8	hSpCas9	negative selection	12385943
27382186	27382209	11	+	28162770	OCIAML3	viability	ACAGCTCTTTAAGGCTAGGAAGG	LGR4	ENSG00000205213	-0.3834406543845048	[104]	[242]	-3	hSpCas9	negative selection	12385944