Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:79648
• Symbol:MCPH1
• Description:microcephalin 1

DataSource: http://genomecrispr.dkfz.de/#!/results/MCPH1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
6445514	6445537	8	+	26472758	Jiyoye	viability	GAGAAGGAAAACTTACCCGGAGG	MCPH1	ENSG00000147316	0.19400149019880408	[181]	[156]	1	hSpCas9	negative selection	97793
6444852	6444875	8	+	26472758	Jiyoye	viability	CCAGGAGATCTATCATGCCGAGG	MCPH1	ENSG00000147316	0.4955312559267203	[94]	[100]	4	hSpCas9	negative selection	97794
6444895	6444918	8	+	26472758	Jiyoye	viability	AGACAGGCTGCAGCACGTGGCGG	MCPH1	ENSG00000147316	0.4071753815058736	[11]	[11]	3	hSpCas9	negative selection	97795
6444923	6444946	8	+	26472758	Jiyoye	viability	GCCCTGGAGGCTCTTAGCTGTGG	MCPH1	ENSG00000147316	2.3571346990062776	[21]	[84]	9	hSpCas9	negative selection	97796
6445010	6445033	8	-	26472758	Jiyoye	viability	GATGGCAGCTGAGATTCAGGAGG	MCPH1	ENSG00000147316	-1.5383768344717499	[207]	[53]	-7	hSpCas9	negative selection	97797
6445264	6445287	8	+	26472758	Jiyoye	viability	GAAAGAAGACGCATGCCCAGAGG	MCPH1	ENSG00000147316	0.8657605964574739	[154]	[212]	6	hSpCas9	negative selection	97798
6445370	6445393	8	+	26472758	Jiyoye	viability	GAAGAAATGAAAGAAGCGGTTGG	MCPH1	ENSG00000147316	1.0446053021211652	[44]	[69]	7	hSpCas9	negative selection	97799
6445394	6445417	8	+	26472758	Jiyoye	viability	CTGAAAAGCACACAGAACAAAGG	MCPH1	ENSG00000147316	2.894441208339896	[27]	[156]	9	hSpCas9	negative selection	97800
6445498	6445521	8	+	26472758	Jiyoye	viability	GGAGACGTCTACAGAAGAGAAGG	MCPH1	ENSG00000147316	0.14414097567207973	[23]	[19]	1	hSpCas9	negative selection	97801
6409288	6409311	8	-	26472758	Jiyoye	viability	GGATGACCACACTTCAACATAGG	MCPH1	ENSG00000147316	-1.7854696964365224	[255]	[55]	-8	hSpCas9	negative selection	97802
6445514	6445537	8	+	26472758	KBM7	viability	GAGAAGGAAAACTTACCCGGAGG	MCPH1	ENSG00000147316	-0.15940830116653149	[595,160]	[126,171]	-1	hSpCas9	negative selection	288911
6444852	6444875	8	+	26472758	KBM7	viability	CCAGGAGATCTATCATGCCGAGG	MCPH1	ENSG00000147316	-0.01985893703434158	[519,336]	[235,158]	0	hSpCas9	negative selection	288912
6444895	6444918	8	+	26472758	KBM7	viability	AGACAGGCTGCAGCACGTGGCGG	MCPH1	ENSG00000147316	0.029433249761785074	[113,33]	[38,28]	0	hSpCas9	negative selection	288913
6444923	6444946	8	+	26472758	KBM7	viability	GCCCTGGAGGCTCTTAGCTGTGG	MCPH1	ENSG00000147316	-0.5102883253925398	[416,211]	[93,106]	-4	hSpCas9	negative selection	288914
6445010	6445033	8	-	26472758	KBM7	viability	GATGGCAGCTGAGATTCAGGAGG	MCPH1	ENSG00000147316	-0.692135546777274	[590,356]	[160,111]	-5	hSpCas9	negative selection	288915
6445264	6445287	8	+	26472758	KBM7	viability	GAAAGAAGACGCATGCCCAGAGG	MCPH1	ENSG00000147316	0.42538299942446206	[786,519]	[499,321]	4	hSpCas9	negative selection	288916
6445370	6445393	8	+	26472758	KBM7	viability	GAAGAAATGAAAGAAGCGGTTGG	MCPH1	ENSG00000147316	0.13939007242403978	[295,145]	[166,60]	1	hSpCas9	negative selection	288917
6445394	6445417	8	+	26472758	KBM7	viability	CTGAAAAGCACACAGAACAAAGG	MCPH1	ENSG00000147316	0.13462403703082504	[538,771]	[399,297]	1	hSpCas9	negative selection	288918
6445498	6445521	8	+	26472758	KBM7	viability	GGAGACGTCTACAGAAGAGAAGG	MCPH1	ENSG00000147316	-1.4207890464241817	[244,241]	[43,41]	-7	hSpCas9	negative selection	288919
6409288	6409311	8	-	26472758	KBM7	viability	GGATGACCACACTTCAACATAGG	MCPH1	ENSG00000147316	-2.7014174660575065	[896,1155]	[93,58]	-9	hSpCas9	negative selection	288920
6445514	6445537	8	+	26472758	Raji	viability	GAGAAGGAAAACTTACCCGGAGG	MCPH1	ENSG00000147316	0.6120582471371196	[233]	[82]	6	hSpCas9	negative selection	480029
6444852	6444875	8	+	26472758	Raji	viability	CCAGGAGATCTATCATGCCGAGG	MCPH1	ENSG00000147316	-0.5602466230173913	[412]	[64]	-4	hSpCas9	negative selection	480030
6444895	6444918	8	+	26472758	Raji	viability	AGACAGGCTGCAGCACGTGGCGG	MCPH1	ENSG00000147316	-1.725506478791142	[56]	[3]	-8	hSpCas9	negative selection	480031
6444923	6444946	8	+	26472758	Raji	viability	GCCCTGGAGGCTCTTAGCTGTGG	MCPH1	ENSG00000147316	0.3062876037876777	[114]	[32]	3	hSpCas9	negative selection	480032
6445010	6445033	8	-	26472758	Raji	viability	GATGGCAGCTGAGATTCAGGAGG	MCPH1	ENSG00000147316	-0.9832190134073072	[229]	[26]	-6	hSpCas9	negative selection	480033
6445264	6445287	8	+	26472758	Raji	viability	GAAAGAAGACGCATGCCCAGAGG	MCPH1	ENSG00000147316	1.5971888030544155	[187]	[131]	9	hSpCas9	negative selection	480034
6445370	6445393	8	+	26472758	Raji	viability	GAAGAAATGAAAGAAGCGGTTGG	MCPH1	ENSG00000147316	-1.4675253006836337	[142]	[11]	-7	hSpCas9	negative selection	480035
6445394	6445417	8	+	26472758	Raji	viability	CTGAAAAGCACACAGAACAAAGG	MCPH1	ENSG00000147316	0.09263695000441335	[294]	[72]	0	hSpCas9	negative selection	480036
6445498	6445521	8	+	26472758	Raji	viability	GGAGACGTCTACAGAAGAGAAGG	MCPH1	ENSG00000147316	-0.28493388740516057	[62]	[11]	-2	hSpCas9	negative selection	480037
6409288	6409311	8	-	26472758	Raji	viability	GGATGACCACACTTCAACATAGG	MCPH1	ENSG00000147316	-0.37751201024363445	[542]	[96]	-3	hSpCas9	negative selection	480038
6445514	6445537	8	+	26472758	K562	viability	GAGAAGGAAAACTTACCCGGAGG	MCPH1	ENSG00000147316	0.47173923249974703	[333]	[390]	4	hSpCas9	negative selection	671147
6444852	6444875	8	+	26472758	K562	viability	CCAGGAGATCTATCATGCCGAGG	MCPH1	ENSG00000147316	1.0373224934265106	[343]	[595]	8	hSpCas9	negative selection	671148
6444895	6444918	8	+	26472758	K562	viability	AGACAGGCTGCAGCACGTGGCGG	MCPH1	ENSG00000147316	1.0625804046806335	[75]	[133]	8	hSpCas9	negative selection	671149
6444923	6444946	8	+	26472758	K562	viability	GCCCTGGAGGCTCTTAGCTGTGG	MCPH1	ENSG00000147316	-0.6515582077903247	[213]	[114]	-4	hSpCas9	negative selection	671150
6445010	6445033	8	-	26472758	K562	viability	GATGGCAGCTGAGATTCAGGAGG	MCPH1	ENSG00000147316	0.7421588162755403	[249]	[352]	6	hSpCas9	negative selection	671151
6445264	6445287	8	+	26472758	K562	viability	GAAAGAAGACGCATGCCCAGAGG	MCPH1	ENSG00000147316	0.3753322157296422	[378]	[414]	3	hSpCas9	negative selection	671152
6445370	6445393	8	+	26472758	K562	viability	GAAGAAATGAAAGAAGCGGTTGG	MCPH1	ENSG00000147316	-0.06006039646469852	[225]	[182]	0	hSpCas9	negative selection	671153
6445394	6445417	8	+	26472758	K562	viability	CTGAAAAGCACACAGAACAAAGG	MCPH1	ENSG00000147316	0.5334404053473232	[540]	[660]	4	hSpCas9	negative selection	671154
6445498	6445521	8	+	26472758	K562	viability	GGAGACGTCTACAGAAGAGAAGG	MCPH1	ENSG00000147316	-1.381185757552055	[215]	[69]	-6	hSpCas9	negative selection	671155
6409288	6409311	8	-	26472758	K562	viability	GGATGACCACACTTCAACATAGG	MCPH1	ENSG00000147316	-0.07053485749213051	[876]	[704]	0	hSpCas9	negative selection	671156
6406678	6406701	8	-	26627737	DLD1	viability	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-1.6809504136563513	[177]	[7,0,38]	-8	hSpCas9	negative selection	839871
6431491	6431514	8	+	26627737	DLD1	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.5767779512200834	[427]	[58,141,72]	-5	hSpCas9	negative selection	839872
6445237	6445260	8	+	26627737	DLD1	viability	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	0.931500838110826	[198]	[64,212,86]	8	hSpCas9	negative selection	839873
6480811	6480834	8	-	26627737	DLD1	viability	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	0.6990957015904096	[15]	[2,9,10]	7	hSpCas9	negative selection	839874
6406678	6406701	8	-	26627737	GBM cells	viability after 5 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-0.7766511746163771	[114]	[31,39]	-8	hSpCas9	negative selection	922186
6431491	6431514	8	+	26627737	GBM cells	viability after 5 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	0.12356934773070252	[272]	[143,174]	2	hSpCas9	negative selection	922187
6445237	6445260	8	+	26627737	GBM cells	viability after 5 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	0.36794626380525863	[353]	[253,235]	5	hSpCas9	negative selection	922188
6480811	6480834	8	-	26627737	GBM cells	viability after 5 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	0.7614103511357508	[32]	[30,28]	8	hSpCas9	negative selection	922189
6406678	6406701	8	-	26627737	GBM cells	viability after 13 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-0.964713543588958	[114]	[42,22]	-8	hSpCas9	negative selection	1004501
6431491	6431514	8	+	26627737	GBM cells	viability after 13 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.5284856012075044	[272]	[105,99]	-6	hSpCas9	negative selection	1004502
6445237	6445260	8	+	26627737	GBM cells	viability after 13 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	0.5801804903507903	[353]	[322,257]	7	hSpCas9	negative selection	1004503
6480811	6480834	8	-	26627737	GBM cells	viability after 13 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	1.1025655178164961	[32]	[38,37]	9	hSpCas9	negative selection	1004504
6406678	6406701	8	-	26627737	GBM cells	viability after 21 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-1.9813764166919934	[114]	[19,11]	-9	hSpCas9	negative selection	1086816
6431491	6431514	8	+	26627737	GBM cells	viability after 21 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.9961552075955161	[272]	[65,81]	-7	hSpCas9	negative selection	1086817
6445237	6445260	8	+	26627737	GBM cells	viability after 21 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	0.6720048668811323	[353]	[319,293]	6	hSpCas9	negative selection	1086818
6480811	6480834	8	-	26627737	GBM cells	viability after 21 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	0.9341052580347058	[32]	[39,28]	8	hSpCas9	negative selection	1086819
6406678	6406701	8	-	26627737	RPE1	viability after 9 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-0.5481737747184265	[148]	[13,54]	-4	hSpCas9	negative selection	1169131
6431491	6431514	8	+	26627737	RPE1	viability after 9 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-1.732936531126139	[916]	[81,91]	-8	hSpCas9	negative selection	1169132
6445237	6445260	8	+	26627737	RPE1	viability after 9 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	1.6721685530030865	[632]	[569,710]	8	hSpCas9	negative selection	1169133
6480811	6480834	8	-	26627737	RPE1	viability after 9 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	-1.2014518935291125	[292]	[45,31]	-7	hSpCas9	negative selection	1169134
6406678	6406701	8	-	26627737	RPE1	viability after 12 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-2.094788121115907	[148]	[4,13]	-8	hSpCas9	negative selection	1251446
6431491	6431514	8	+	26627737	RPE1	viability after 12 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-2.553330848310603	[916]	[57,24]	-9	hSpCas9	negative selection	1251447
6445237	6445260	8	+	26627737	RPE1	viability after 12 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	1.788740307913714	[632]	[403,781]	8	hSpCas9	negative selection	1251448
6480811	6480834	8	-	26627737	RPE1	viability after 12 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	-2.119589429554669	[292]	[21,13]	-8	hSpCas9	negative selection	1251449
6406678	6406701	8	-	26627737	RPE1	viability after 15 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-2.9356161490119943	[148]	[4,5]	-9	hSpCas9	negative selection	1333761
6431491	6431514	8	+	26627737	RPE1	viability after 15 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-2.4432759251695946	[916]	[92,3]	-8	hSpCas9	negative selection	1333762
6445237	6445260	8	+	26627737	RPE1	viability after 15 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	1.3777073672560602	[632]	[363,562]	7	hSpCas9	negative selection	1333763
6480811	6480834	8	-	26627737	RPE1	viability after 15 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	-0.47484779004637057	[292]	[79,39]	-3	hSpCas9	negative selection	1333764
6406678	6406701	8	-	26627737	RPE1	viability after 18 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-4.760580602135986	[148]	[0,1]	-9	hSpCas9	negative selection	1416076
6431491	6431514	8	+	26627737	RPE1	viability after 18 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-3.154293459285626	[916]	[50,2]	-9	hSpCas9	negative selection	1416077
6445237	6445260	8	+	26627737	RPE1	viability after 18 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	1.5208025582423743	[632]	[349,639]	7	hSpCas9	negative selection	1416078
6480811	6480834	8	-	26627737	RPE1	viability after 18 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	-1.0763610722695796	[292]	[51,21]	-6	hSpCas9	negative selection	1416079
6406678	6406701	8	-	26627737	HeLa	viability after 8 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-0.5851019997388176	[130]	[61,29,27]	-5	hSpCas9	negative selection	1498391
6431491	6431514	8	+	26627737	HeLa	viability after 8 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.7123857298975786	[684]	[282,43,236]	-6	hSpCas9	negative selection	1498392
6445237	6445260	8	+	26627737	HeLa	viability after 8 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	0.4610461146368765	[380]	[352,247,118]	4	hSpCas9	negative selection	1498393
6480811	6480834	8	-	26627737	HeLa	viability after 8 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	-0.23557631253470168	[28]	[24,9,0]	-2	hSpCas9	negative selection	1498394
6406678	6406701	8	-	26627737	HeLa	viability after 12 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-0.16036401844599335	[130]	[7,30,106]	-1	hSpCas9	negative selection	1580706
6431491	6431514	8	+	26627737	HeLa	viability after 12 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.21877683315981333	[684]	[246,175,313]	-2	hSpCas9	negative selection	1580707
6445237	6445260	8	+	26627737	HeLa	viability after 12 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	0.6719125748891172	[380]	[304,270,175]	5	hSpCas9	negative selection	1580708
6480811	6480834	8	-	26627737	HeLa	viability after 12 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	-0.0914948538889	[28]	[4,25,0]	-1	hSpCas9	negative selection	1580709
6406678	6406701	8	-	26627737	HeLa	viability after 15 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-1.3951707935177302	[130]	[34,0,24]	-8	hSpCas9	negative selection	1663021
6431491	6431514	8	+	26627737	HeLa	viability after 15 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.6235348230027039	[684]	[257,54,232]	-5	hSpCas9	negative selection	1663022
6445237	6445260	8	+	26627737	HeLa	viability after 15 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	0.7502485279657356	[380]	[177,474,119]	6	hSpCas9	negative selection	1663023
6480811	6480834	8	-	26627737	HeLa	viability after 15 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	1.5625728467674542	[28]	[36,63,0]	8	hSpCas9	negative selection	1663024
6406678	6406701	8	-	26627737	HeLa	viability after 18 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-1.4836548823976894	[130]	[20,0,24]	-8	hSpCas9	negative selection	1745336
6431491	6431514	8	+	26627737	HeLa	viability after 18 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.6110617456615333	[684]	[178,41,232]	-5	hSpCas9	negative selection	1745337
6445237	6445260	8	+	26627737	HeLa	viability after 18 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	0.7635989926479135	[380]	[121,395,119]	6	hSpCas9	negative selection	1745338
6480811	6480834	8	-	26627737	HeLa	viability after 18 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	1.4049471562749583	[28]	[16,53,0]	8	hSpCas9	negative selection	1745339
6406678	6406701	8	-	26627737	HCT116	viability after 6 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-0.9819864203938147	[159]	[4,16]	-5	hSpCas9	negative selection	1827651
6431491	6431514	8	+	26627737	HCT116	viability after 6 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.3873518457428453	[535]	[66,62]	-2	hSpCas9	negative selection	1827652
6445237	6445260	8	+	26627737	HCT116	viability after 6 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	1.4153728054253525	[413]	[54,238]	7	hSpCas9	negative selection	1827653
6480811	6480834	8	-	26627737	HCT116	viability after 6 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	6.465338321169923	[0]	[0,20]	9	hSpCas9	negative selection	1827654
6406678	6406701	8	-	26627737	HCT116	viability after 8 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-1.770768238498826	[195]	[33,29,30]	-9	hSpCas9	negative selection	1909966
6431491	6431514	8	+	26627737	HCT116	viability after 8 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.049423201245206314	[315]	[156,213,133]	0	hSpCas9	negative selection	1909967
6445237	6445260	8	+	26627737	HCT116	viability after 8 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	0.8020270376100108	[260]	[224,374,152]	7	hSpCas9	negative selection	1909968
6480811	6480834	8	-	26627737	HCT116	viability after 8 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	0.3209559459908371	[65]	[71,38,25]	3	hSpCas9	negative selection	1909969
6406678	6406701	8	-	26627737	HCT116	viability after 9 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-0.8798773280243803	[159]	[44,5]	-6	hSpCas9	negative selection	1992281
6431491	6431514	8	+	26627737	HCT116	viability after 9 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-2.220805625228572	[535]	[23,35]	-9	hSpCas9	negative selection	1992282
6445237	6445260	8	+	26627737	HCT116	viability after 9 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	1.5704410942223492	[413]	[434,243]	8	hSpCas9	negative selection	1992283
6480811	6480834	8	-	26627737	HCT116	viability after 9 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	6.892343456866493	[0]	[0,55]	9	hSpCas9	negative selection	1992284
6406678	6406701	8	-	26627737	HCT116	viability after 12 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-1.4182130587532105	[195]	[22,38,54]	-8	hSpCas9	negative selection	2074596
6431491	6431514	8	+	26627737	HCT116	viability after 12 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.28231971957954183	[315]	[132,137,138]	-3	hSpCas9	negative selection	2074597
6445237	6445260	8	+	26627737	HCT116	viability after 12 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	1.1177915628120112	[260]	[109,566,238]	8	hSpCas9	negative selection	2074598
6480811	6480834	8	-	26627737	HCT116	viability after 12 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	-1.571069621491397	[65]	[21,6,4]	-9	hSpCas9	negative selection	2074599
6406678	6406701	8	-	26627737	HCT116	viability after 15 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-1.8232552337720995	[195]	[7,8,74]	-9	hSpCas9	negative selection	2156911
6431491	6431514	8	+	26627737	HCT116	viability after 15 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.7818185415195791	[315]	[156,66,98]	-7	hSpCas9	negative selection	2156912
6445237	6445260	8	+	26627737	HCT116	viability after 15 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	1.1899899306058168	[260]	[282,496,239]	8	hSpCas9	negative selection	2156913
6480811	6480834	8	-	26627737	HCT116	viability after 15 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	-1.4832720596440185	[65]	[15,13,10]	-8	hSpCas9	negative selection	2156914
6406678	6406701	8	-	26627737	HCT116	viability after 18 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-2.9562916320337065	[195]	[5,2,28]	-9	hSpCas9	negative selection	2239226
6431491	6431514	8	+	26627737	HCT116	viability after 18 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.26295417087679307	[315]	[165,110,104]	-2	hSpCas9	negative selection	2239227
6445237	6445260	8	+	26627737	HCT116	viability after 18 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	0.8989278236837448	[260]	[193,310,193]	7	hSpCas9	negative selection	2239228
6480811	6480834	8	-	26627737	HCT116	viability after 18 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	-1.836854746775764	[65]	[23,0,1]	-9	hSpCas9	negative selection	2239229
6563427	6563450	8	-	25494202	A375	resistance to PLX-4720 (puromycin)	ACAGATCGGTTTTTCCCAGAGGG	MCPH1	ENSG00000147316	2.4789578221380424	[39,45]	[79,22]	8	dCas9-VP64	positive selection	2397160
6473340	6473363	8	+	25494202	A375	resistance to PLX-4720 (puromycin)	TTTTTTTTTGAGACGGAGTCGGG	MCPH1	ENSG00000147316	-0.0033727294007129816	[93,134]	[41,5]	0	dCas9-VP64	positive selection	2412630
6414215	6414238	8	-	25494202	A375	resistance to PLX-4720 (puromycin)	TCAGCAGTTTGAGACCAGCCTAG	MCPH1	ENSG00000147316	-2.729845497757659	[196,428]	[6,13]	-9	dCas9-VP64	positive selection	2412701
6480265	6480288	8	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGCGCGTGCCACCACGCCTGG	MCPH1	ENSG00000147316	2.643483847646077	[13,290]	[2,439]	8	dCas9-VP64	positive selection	2433911
6422737	6422760	8	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGAGTGCAGTGGTGCGATCTCGG	MCPH1	ENSG00000147316	4.070372888524917	[22,16]	[45,107]	9	dCas9-VP64	positive selection	2443455
6433515	6433538	8	+	25494202	A375	resistance to PLX-4720 (puromycin)	CCCAGCTACTCAGGAGGCTGAGG	MCPH1	ENSG00000147316	1.0101159834039155	[15,74]	[1,39]	4	dCas9-VP64	positive selection	2458850
6563427	6563450	8	-	25494202	A375	resistance to PLX-4720 (zeocin)	ACAGATCGGTTTTTCCCAGAGGG	MCPH1	ENSG00000147316	0.03131413332307709	[66,86]	[26,22]	0	dCas9-VP64	positive selection	2492415
6473340	6473363	8	+	25494202	A375	resistance to PLX-4720 (zeocin)	TTTTTTTTTGAGACGGAGTCGGG	MCPH1	ENSG00000147316	-0.5948176551250917	[72,353]	[48,41]	-6	dCas9-VP64	positive selection	2507885
6414215	6414238	8	-	25494202	A375	resistance to PLX-4720 (zeocin)	TCAGCAGTTTGAGACCAGCCTAG	MCPH1	ENSG00000147316	-1.135721094933603	[195,105]	[22,20]	-9	dCas9-VP64	positive selection	2507956
6480265	6480288	8	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGCGCGTGCCACCACGCCTGG	MCPH1	ENSG00000147316	0.7224579133223353	[33,61]	[16,32]	5	dCas9-VP64	positive selection	2529166
6422737	6422760	8	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGAGTGCAGTGGTGCGATCTCGG	MCPH1	ENSG00000147316	1.6841538162097147	[121,126]	[189,75]	8	dCas9-VP64	positive selection	2538710
6433515	6433538	8	+	25494202	A375	resistance to PLX-4720 (zeocin)	CCCAGCTACTCAGGAGGCTGAGG	MCPH1	ENSG00000147316	-0.13736370075198145	[6,190]	[3,51]	-1	dCas9-VP64	positive selection	2554105
6414810	6414833	8	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	AGATGGCTACCAGAGCACTTGGG	MCPH1	ENSG00000147316	-0.938145489826361	[2,3]	[0,0]	-9	hSpCas9	positive selection	3001684
6414858	6414881	8	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCTCGTTTCGGTGCTCTGGGTGG	MCPH1	ENSG00000147316	0.44850396598249714	[3,3]	[4,4]	8	hSpCas9	positive selection	3001685
6442123	6442146	8	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTATCACGTGAAATGTTCAAAGG	MCPH1	ENSG00000147316	0.15526637318081504	[3,3]	[4,3]	3	hSpCas9	positive selection	3001686
6431538	6431561	8	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTTCATTCATATTAGCTGCAGGG	MCPH1	ENSG00000147316	-0.11258555646559004	[4,4]	[2,4]	-2	hSpCas9	positive selection	3001687
6414810	6414833	8	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	AGATGGCTACCAGAGCACTTGGG	MCPH1	ENSG00000147316	-0.2106826754637127	[2,2]	[1,1]	-3	hSpCas9	positive selection	3069542
6414858	6414881	8	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCTCGTTTCGGTGCTCTGGGTGG	MCPH1	ENSG00000147316	-0.2147270296644988	[3,3]	[3,1]	-3	hSpCas9	positive selection	3069543
6442123	6442146	8	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTATCACGTGAAATGTTCAAAGG	MCPH1	ENSG00000147316	0.27542981526425325	[3,3]	[4,2]	5	hSpCas9	positive selection	3069544
6431538	6431561	8	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTTCATTCATATTAGCTGCAGGG	MCPH1	ENSG00000147316	0.2581890071277711	[4,4]	[3,3]	4	hSpCas9	positive selection	3069545
6414853	6414876		+	24336571	A375	resistance to PLX after 7 days	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	-0.2093511352913351	[34,33]	[27,31]	-6	hSpCas9	positive selection	3126843
6409282	6409305		+	24336571	A375	resistance to PLX after 7 days	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	0.3820127661628856	[14,13]	[19,17]	8	hSpCas9	positive selection	3126844
6414853	6414876		+	24336571	A375	resistance to PLX after 14 days	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	-0.33358065641997103	[37,28]	[12,10]	-4	hSpCas9	positive selection	3184636
6409282	6409305		+	24336571	A375	resistance to PLX after 14 days	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	0.4599242090114991	[5,8]	[3,4]	4	hSpCas9	positive selection	3184637
6414853	6414876		+	24336571	A375	viability after 7 days	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.46293790932868695	[25]	[34,33]	7	hSpCas9	negative selection	3242429
6409282	6409305		+	24336571	A375	viability after 7 days	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-1.164738763360869	[34]	[14,13]	-9	hSpCas9	negative selection	3242430
6414853	6414876		+	24336571	A375	viability after 14 days	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.4331348812445277	[25]	[37,28]	5	hSpCas9	negative selection	3300222
6409282	6409305		+	24336571	A375	viability after 14 days	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-2.075702156466078	[34]	[5,8]	-9	hSpCas9	negative selection	3300223
6431539	6431562	8	-	27383988	293T	resistance to West Nile virus (flavivirus)	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	-1.2895682484418016	[373,373]	[0,0]	-8	hSpCas9	positive selection	3378813
6414818	6414841	8	-	27383988	293T	resistance to West Nile virus (flavivirus)	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	2.3031299010589596	[30,30]	[0,0]	8	hSpCas9	positive selection	3378814
6431491	6431514	8	+	27383988	293T	resistance to West Nile virus (flavivirus)	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.35000410230377543	[194,194]	[0,0]	-2	hSpCas9	positive selection	3378815
6414809	6414832	8	+	26780180	HT29	viability (Avana library 4 designs)	AGATGGCTACCAGAGCACTTGGG	MCPH1	ENSG00000147316	2.51697451154488	[]	[]	8	hSpCas9	negative selection	3439408
6414857	6414880	8	+	26780180	HT29	viability (Avana library 4 designs)	GCTCGTTTCGGTGCTCTGGGTGG	MCPH1	ENSG00000147316	-0.664490839090372	[]	[]	-8	hSpCas9	negative selection	3439409
6442123	6442146	8	-	26780180	HT29	viability (Avana library 4 designs)	GTATCACGTGAAATGTTCAAAGG	MCPH1	ENSG00000147316	0.255194815188002	[]	[]	0	hSpCas9	negative selection	3439410
6431538	6431561	8	-	26780180	HT29	viability (Avana library 4 designs)	GTTCATTCATATTAGCTGCAGGG	MCPH1	ENSG00000147316	0.145382963854642	[]	[]	0	hSpCas9	negative selection	3439411
6442123	6442146	8	-	26780180	A375	viability (Avana lentiCRISPRv2)	GTATCACGTGAAATGTTCAAAGG	MCPH1	ENSG00000147316	-3.00981676465421	[]	[]	-4	hSpCas9	negative selection	3529140
6431538	6431561	8	-	26780180	A375	viability (Avana lentiCRISPRv2)	GTTCATTCATATTAGCTGCAGGG	MCPH1	ENSG00000147316	-5.94041596603878	[]	[]	-6	hSpCas9	negative selection	3529141
6414809	6414832	8	+	26780180	A375	viability (Avana lentiCRISPRv2)	AGATGGCTACCAGAGCACTTGGG	MCPH1	ENSG00000147316	3.10270091950904	[]	[]	5	hSpCas9	negative selection	3529142
6414857	6414880	8	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCTCGTTTCGGTGCTCTGGGTGG	MCPH1	ENSG00000147316	0.560512802350418	[]	[]	0	hSpCas9	negative selection	3529143
6409288	6409311	8	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGATGACCACACTTCAACATAGG	MCPH1	ENSG00000147316	-11.9641498259381	[]	[]	-8	hSpCas9	negative selection	3529144
6409293	6409316	8	+	26780180	A375	viability (Avana lentiCRISPRv2)	GTTGAAGTGTGGTCATCCAATGG	MCPH1	ENSG00000147316	-8.10698969462037	[]	[]	-7	hSpCas9	negative selection	3529145
6442123	6442146	8	-	26780180	A375	viability (Avana lentiGuide)	GTATCACGTGAAATGTTCAAAGG	MCPH1	ENSG00000147316	0.791147605239268	[]	[]	1	hSpCas9	negative selection	3637799
6431538	6431561	8	-	26780180	A375	viability (Avana lentiGuide)	GTTCATTCATATTAGCTGCAGGG	MCPH1	ENSG00000147316	2.04569211953809	[]	[]	2	hSpCas9	negative selection	3637800
6414809	6414832	8	+	26780180	A375	viability (Avana lentiGuide)	AGATGGCTACCAGAGCACTTGGG	MCPH1	ENSG00000147316	6.30578582066849	[]	[]	5	hSpCas9	negative selection	3637801
6414857	6414880	8	+	26780180	A375	viability (Avana lentiGuide)	GCTCGTTTCGGTGCTCTGGGTGG	MCPH1	ENSG00000147316	-2.48027075326129	[]	[]	-4	hSpCas9	negative selection	3637802
6409288	6409311	8	-	26780180	A375	viability (Avana lentiGuide)	GGATGACCACACTTCAACATAGG	MCPH1	ENSG00000147316	13.0591048375814	[]	[]	7	hSpCas9	negative selection	3637803
6409293	6409316	8	+	26780180	A375	viability (Avana lentiGuide)	GTTGAAGTGTGGTCATCCAATGG	MCPH1	ENSG00000147316	12.8351848346476	[]	[]	7	hSpCas9	negative selection	3637804
6442123	6442146	8	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTATCACGTGAAATGTTCAAAGG	MCPH1	ENSG00000147316	-0.2926724389394031	[5]	[4,3]	-4	hSpCas9	positive selection	3746458
6431538	6431561	8	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTTCATTCATATTAGCTGCAGGG	MCPH1	ENSG00000147316	-0.616154425077809	[6]	[3,3]	-7	hSpCas9	positive selection	3746459
6414809	6414832	8	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AGATGGCTACCAGAGCACTTGGG	MCPH1	ENSG00000147316	0.018835602072140606	[4]	[4,4]	0	hSpCas9	positive selection	3746460
6414857	6414880	8	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCTCGTTTCGGTGCTCTGGGTGG	MCPH1	ENSG00000147316	-0.009823458728992901	[4]	[4,4]	0	hSpCas9	positive selection	3746461
6409288	6409311	8	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGATGACCACACTTCAACATAGG	MCPH1	ENSG00000147316	-1.177158112023421	[3]	[0,1]	-9	hSpCas9	positive selection	3746462
6409293	6409316	8	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTTGAAGTGTGGTCATCCAATGG	MCPH1	ENSG00000147316	-0.5068047173406287	[4]	[3,2]	-6	hSpCas9	positive selection	3746463
6442123	6442146	8	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTATCACGTGAAATGTTCAAAGG	MCPH1	ENSG00000147316	0.038460318417212744	[5]	[4,5]	0	hSpCas9	positive selection	3855065
6431538	6431561	8	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTTCATTCATATTAGCTGCAGGG	MCPH1	ENSG00000147316	0.07683116938132203	[5]	[5,4]	1	hSpCas9	positive selection	3855066
6414809	6414832	8	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AGATGGCTACCAGAGCACTTGGG	MCPH1	ENSG00000147316	-0.0569587203612652	[4]	[4,2]	-1	hSpCas9	positive selection	3855067
6414857	6414880	8	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCTCGTTTCGGTGCTCTGGGTGG	MCPH1	ENSG00000147316	0.21263074955811034	[5]	[5,5]	5	hSpCas9	positive selection	3855068
6409288	6409311	8	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGATGACCACACTTCAACATAGG	MCPH1	ENSG00000147316	-0.6568176291994621	[5]	[3,2]	-7	hSpCas9	positive selection	3855069
6409293	6409316	8	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTTGAAGTGTGGTCATCCAATGG	MCPH1	ENSG00000147316	-0.2552872961978942	[4]	[4,2]	-3	hSpCas9	positive selection	3855070
6409334	6409357	8	+	26780180	A375	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	1.3363295720588	[]	[]	7	hSpCas9	negative selection	3960539
6414818	6414841	8	-	26780180	A375	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	1.34889205397842	[]	[]	7	hSpCas9	negative selection	3960540
6414853	6414876	8	+	26780180	A375	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	1.35357120043591	[]	[]	7	hSpCas9	negative selection	3960541
6409282	6409305	8	+	26780180	A375	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	1.52407481278769	[]	[]	8	hSpCas9	negative selection	3960542
6431539	6431562	8	-	26780180	A375	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	0.686950090824286	[]	[]	2	hSpCas9	negative selection	3960543
6431491	6431514	8	+	26780180	A375	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	2.14307578149535	[]	[]	9	hSpCas9	negative selection	3960544
6409334	6409357	8	+	26780180	HT29	viability (GeCKOv2 library)	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.106091424949204	[]	[]	0	hSpCas9	negative selection	4068505
6414818	6414841	8	-	26780180	HT29	viability (GeCKOv2 library)	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	1.53827449809623	[]	[]	7	hSpCas9	negative selection	4068506
6414853	6414876	8	+	26780180	HT29	viability (GeCKOv2 library)	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	1.43808455976777	[]	[]	7	hSpCas9	negative selection	4068507
6409282	6409305	8	+	26780180	HT29	viability (GeCKOv2 library)	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	0.498974557141595	[]	[]	1	hSpCas9	negative selection	4068508
6431539	6431562	8	-	26780180	HT29	viability (GeCKOv2 library)	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	1.10244273853795	[]	[]	5	hSpCas9	negative selection	4068509
6431491	6431514	8	+	26780180	HT29	viability (GeCKOv2 library)	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	2.08716644135153	[]	[]	9	hSpCas9	negative selection	4068510
6414853	6414876	8	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.1167099171277986	[5]	[3,3]	3	hSpCas9	positive selection	4151139
6409282	6409305	8	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.255753793530957	[4]	[2,2]	-6	hSpCas9	positive selection	4151140
6414853	6414876	8	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	1.096290872269161	[4]	[0,2,4,4]	8	hSpCas9	positive selection	4215161
6409282	6409305	8	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.16300511107791363	[5]	[1,3,3,0]	-2	hSpCas9	positive selection	4215162
6414853	6414876	8	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.33791560931246	[2]	[2,2]	7	hSpCas9	positive selection	4282305
6409282	6409305	8	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.12780076828472983	[3]	[3,1]	-3	hSpCas9	positive selection	4282306
6409334	6409357	8	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.2517917691848667	[3]	[3,2]	5	hSpCas9	positive selection	4282307
6431539	6431562	8	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	0.42434157303231956	[3]	[3,4]	8	hSpCas9	positive selection	4346563
6414818	6414841	8	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.5286134009839565	[1]	[0,0]	-8	hSpCas9	positive selection	4346564
6431491	6431514	8	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.46275037930154234	[3]	[2,0]	-7	hSpCas9	positive selection	4346565
6414793	6414815	8	+	27760321	OCIAML3	viability	CTCACGTTATCTTCAAAGATGG	MCPH1	ENSG00000147316	0.1911087707618102	[111,94]	[39,159]	2	hSpCas9	negative selection	4417366
6414809	6414831	8	+	27760321	OCIAML3	viability	AGATGGCTACCAGAGCACTTGG	MCPH1	ENSG00000147316	-0.2720961867745172	[397,352]	[224,265]	-3	hSpCas9	negative selection	4417367
6444390	6444412	8	+	27760321	OCIAML3	viability	CAGATGAATACTTTGCTGGTGG	MCPH1	ENSG00000147316	0.5080811811778634	[578,447]	[451,716]	6	hSpCas9	negative selection	4417368
6444554	6444576	8	-	27760321	OCIAML3	viability	TATCGAGGTGAGTGAAAGATGG	MCPH1	ENSG00000147316	-0.05351354524342433	[94,77]	[40,95]	0	hSpCas9	negative selection	4417369
6444748	6444770	8	-	27760321	OCIAML3	viability	GGGTCTTGAATGTATCAAAAGG	MCPH1	ENSG00000147316	-1.1495513968643039	[31,53]	[18,10]	-7	hSpCas9	negative selection	4417370
6414793	6414815	8	+	27760321	OCIAML2	viability	CTCACGTTATCTTCAAAGATGG	MCPH1	ENSG00000147316	-0.5991007725071262	[111,94]	[42,70]	-6	hSpCas9	negative selection	4500829
6414809	6414831	8	+	27760321	OCIAML2	viability	AGATGGCTACCAGAGCACTTGG	MCPH1	ENSG00000147316	-0.887559421975827	[397,352]	[153,176]	-7	hSpCas9	negative selection	4500830
6444390	6444412	8	+	27760321	OCIAML2	viability	CAGATGAATACTTTGCTGGTGG	MCPH1	ENSG00000147316	0.3703908405796456	[578,447]	[492,585]	5	hSpCas9	negative selection	4500831
6444554	6444576	8	-	27760321	OCIAML2	viability	TATCGAGGTGAGTGAAAGATGG	MCPH1	ENSG00000147316	-0.124760129087921	[94,77]	[40,93]	-2	hSpCas9	negative selection	4500832
6444748	6444770	8	-	27760321	OCIAML2	viability	GGGTCTTGAATGTATCAAAAGG	MCPH1	ENSG00000147316	0.4963547939998194	[31,53]	[32,72]	6	hSpCas9	negative selection	4500833
6414793	6414815	8	+	27760321	MV411	viability	CTCACGTTATCTTCAAAGATGG	MCPH1	ENSG00000147316	-0.450372826770407	[111,94]	[64,26]	-3	hSpCas9	negative selection	4584292
6414809	6414831	8	+	27760321	MV411	viability	AGATGGCTACCAGAGCACTTGG	MCPH1	ENSG00000147316	-1.3194381703853884	[397,352]	[9,232]	-7	hSpCas9	negative selection	4584293
6444390	6444412	8	+	27760321	MV411	viability	CAGATGAATACTTTGCTGGTGG	MCPH1	ENSG00000147316	0.1730220401542375	[578,447]	[246,577]	1	hSpCas9	negative selection	4584294
6444554	6444576	8	-	27760321	MV411	viability	TATCGAGGTGAGTGAAAGATGG	MCPH1	ENSG00000147316	-0.16091918467856559	[94,77]	[65,27]	-1	hSpCas9	negative selection	4584295
6444748	6444770	8	-	27760321	MV411	viability	GGGTCTTGAATGTATCAAAAGG	MCPH1	ENSG00000147316	-1.3513303562840449	[31,53]	[0,26]	-7	hSpCas9	negative selection	4584296
6414793	6414815	8	+	27760321	HL60	viability	CTCACGTTATCTTCAAAGATGG	MCPH1	ENSG00000147316	0.4971209841581776	[111,94]	[82,156]	6	hSpCas9	negative selection	4667755
6414809	6414831	8	+	27760321	HL60	viability	AGATGGCTACCAGAGCACTTGG	MCPH1	ENSG00000147316	0.5662253121944367	[397,352]	[450,455]	6	hSpCas9	negative selection	4667756
6444390	6444412	8	+	27760321	HL60	viability	CAGATGAATACTTTGCTGGTGG	MCPH1	ENSG00000147316	0.7633464716405143	[578,447]	[603,815]	8	hSpCas9	negative selection	4667757
6444554	6444576	8	-	27760321	HL60	viability	TATCGAGGTGAGTGAAAGATGG	MCPH1	ENSG00000147316	-0.07876175570874278	[94,77]	[85,45]	-1	hSpCas9	negative selection	4667758
6444748	6444770	8	-	27760321	HL60	viability	GGGTCTTGAATGTATCAAAAGG	MCPH1	ENSG00000147316	0.2679630995600424	[31,53]	[53,31]	3	hSpCas9	negative selection	4667759
6414793	6414815	8	+	27760321	HT1080	viability	CTCACGTTATCTTCAAAGATGG	MCPH1	ENSG00000147316	-0.056798759811902855	[94,73]	[60,0]	0	hSpCas9	negative selection	4751218
6414809	6414831	8	+	27760321	HT1080	viability	AGATGGCTACCAGAGCACTTGG	MCPH1	ENSG00000147316	-3.913183975583972	[352,275]	[14,0]	-8	hSpCas9	negative selection	4751219
6444390	6444412	8	+	27760321	HT1080	viability	CAGATGAATACTTTGCTGGTGG	MCPH1	ENSG00000147316	-0.5438262931314828	[447,349]	[14,211]	-2	hSpCas9	negative selection	4751220
6444554	6444576	8	-	27760321	HT1080	viability	TATCGAGGTGAGTGAAAGATGG	MCPH1	ENSG00000147316	-4.791305505338062	[77,60]	[0,0]	-8	hSpCas9	negative selection	4751221
6444748	6444770	8	-	27760321	HT1080	viability	GGGTCTTGAATGTATCAAAAGG	MCPH1	ENSG00000147316	2.2686899688689826	[53,41]	[157,19]	9	hSpCas9	negative selection	4751222
6414793	6414815	8	+	27760321	HT29	viability after 7 days	CTCACGTTATCTTCAAAGATGG	MCPH1	ENSG00000147316	0.6607091523058466	[94,73]	[118,266,122]	8	hSpCas9	negative selection	4834681
6414809	6414831	8	+	27760321	HT29	viability after 7 days	AGATGGCTACCAGAGCACTTGG	MCPH1	ENSG00000147316	0.3262999751823421	[352,275]	[387,690,426]	5	hSpCas9	negative selection	4834682
6444390	6444412	8	+	27760321	HT29	viability after 7 days	CAGATGAATACTTTGCTGGTGG	MCPH1	ENSG00000147316	0.531332348827624	[447,349]	[721,707,788]	7	hSpCas9	negative selection	4834683
6444554	6444576	8	-	27760321	HT29	viability after 7 days	TATCGAGGTGAGTGAAAGATGG	MCPH1	ENSG00000147316	-0.17366384076262387	[77,60]	[77,98,60]	-3	hSpCas9	negative selection	4834684
6444748	6444770	8	-	27760321	HT29	viability after 7 days	GGGTCTTGAATGTATCAAAAGG	MCPH1	ENSG00000147316	-1.1560113665538418	[53,41]	[8,63,7]	-8	hSpCas9	negative selection	4834685
6414793	6414815	8	+	27760321	HT29	viability after 25 days	CTCACGTTATCTTCAAAGATGG	MCPH1	ENSG00000147316	0.620971898699755	[94,73]	[96,215,133]	7	hSpCas9	negative selection	4918144
6414809	6414831	8	+	27760321	HT29	viability after 25 days	AGATGGCTACCAGAGCACTTGG	MCPH1	ENSG00000147316	-0.3039607302221539	[352,275]	[213,285,387]	-3	hSpCas9	negative selection	4918145
6444390	6444412	8	+	27760321	HT29	viability after 25 days	CAGATGAATACTTTGCTGGTGG	MCPH1	ENSG00000147316	0.5688499381081988	[447,349]	[787,687,529]	6	hSpCas9	negative selection	4918146
6444554	6444576	8	-	27760321	HT29	viability after 25 days	TATCGAGGTGAGTGAAAGATGG	MCPH1	ENSG00000147316	-0.18569492441142943	[77,60]	[72,119,9]	-2	hSpCas9	negative selection	4918147
6444748	6444770	8	-	27760321	HT29	viability after 25 days	GGGTCTTGAATGTATCAAAAGG	MCPH1	ENSG00000147316	0.03140364450185551	[53,41]	[54,40,73]	0	hSpCas9	negative selection	4918148
6414793	6414815	8	+	27760321	HT29	viability after 22 days	CTCACGTTATCTTCAAAGATGG	MCPH1	ENSG00000147316	0.6042673924294963	[94,73]	[84,230,130]	6	hSpCas9	negative selection	5001607
6414809	6414831	8	+	27760321	HT29	viability after 22 days	AGATGGCTACCAGAGCACTTGG	MCPH1	ENSG00000147316	0.05034236057562974	[352,275]	[481,343,299]	0	hSpCas9	negative selection	5001608
6444390	6444412	8	+	27760321	HT29	viability after 22 days	CAGATGAATACTTTGCTGGTGG	MCPH1	ENSG00000147316	0.6114834112293651	[447,349]	[709,715,687]	6	hSpCas9	negative selection	5001609
6444554	6444576	8	-	27760321	HT29	viability after 22 days	TATCGAGGTGAGTGAAAGATGG	MCPH1	ENSG00000147316	-0.6780976944449653	[77,60]	[7,72,70]	-5	hSpCas9	negative selection	5001610
6444748	6444770	8	-	27760321	HT29	viability after 22 days	GGGTCTTGAATGTATCAAAAGG	MCPH1	ENSG00000147316	-0.4413259971146033	[53,41]	[30,33,57]	-4	hSpCas9	negative selection	5001611
6414793	6414815	8	+	27760321	HT29	viability after 19 days	CTCACGTTATCTTCAAAGATGG	MCPH1	ENSG00000147316	1.141155818194826	[94,73]	[149,118,357]	9	hSpCas9	negative selection	5085070
6414809	6414831	8	+	27760321	HT29	viability after 19 days	AGATGGCTACCAGAGCACTTGG	MCPH1	ENSG00000147316	0.09338242818382274	[352,275]	[607,167,397]	0	hSpCas9	negative selection	5085071
6444390	6444412	8	+	27760321	HT29	viability after 19 days	CAGATGAATACTTTGCTGGTGG	MCPH1	ENSG00000147316	0.9140222697737231	[447,349]	[700,1014,846]	8	hSpCas9	negative selection	5085072
6444554	6444576	8	-	27760321	HT29	viability after 19 days	TATCGAGGTGAGTGAAAGATGG	MCPH1	ENSG00000147316	0.3488963889076939	[77,60]	[222,7,85]	3	hSpCas9	negative selection	5085073
6444748	6444770	8	-	27760321	HT29	viability after 19 days	GGGTCTTGAATGTATCAAAAGG	MCPH1	ENSG00000147316	-1.2632656913457296	[53,41]	[56,14,0]	-7	hSpCas9	negative selection	5085074
6414793	6414815	8	+	27760321	HT29	viability after 16 days	CTCACGTTATCTTCAAAGATGG	MCPH1	ENSG00000147316	-0.08198148807732553	[94,73]	[61,139,61]	-1	hSpCas9	negative selection	5168533
6414809	6414831	8	+	27760321	HT29	viability after 16 days	AGATGGCTACCAGAGCACTTGG	MCPH1	ENSG00000147316	0.5421828583288469	[352,275]	[439,564,523]	6	hSpCas9	negative selection	5168534
6444390	6444412	8	+	27760321	HT29	viability after 16 days	CAGATGAATACTTTGCTGGTGG	MCPH1	ENSG00000147316	0.4209430449241499	[447,349]	[915,521,386]	5	hSpCas9	negative selection	5168535
6444554	6444576	8	-	27760321	HT29	viability after 16 days	TATCGAGGTGAGTGAAAGATGG	MCPH1	ENSG00000147316	0.7660938136626012	[77,60]	[209,58,136]	8	hSpCas9	negative selection	5168536
6444748	6444770	8	-	27760321	HT29	viability after 16 days	GGGTCTTGAATGTATCAAAAGG	MCPH1	ENSG00000147316	-0.5050978370645369	[53,41]	[40,67,3]	-5	hSpCas9	negative selection	5168537
6414793	6414815	8	+	27760321	HT29	viability after 13 days	CTCACGTTATCTTCAAAGATGG	MCPH1	ENSG00000147316	0.6469082861542468	[94,73]	[304,68,89]	8	hSpCas9	negative selection	5251996
6414809	6414831	8	+	27760321	HT29	viability after 13 days	AGATGGCTACCAGAGCACTTGG	MCPH1	ENSG00000147316	0.3298775435176166	[352,275]	[376,505,490]	4	hSpCas9	negative selection	5251997
6444390	6444412	8	+	27760321	HT29	viability after 13 days	CAGATGAATACTTTGCTGGTGG	MCPH1	ENSG00000147316	0.4924802716154054	[447,349]	[603,753,598]	6	hSpCas9	negative selection	5251998
6444554	6444576	8	-	27760321	HT29	viability after 13 days	TATCGAGGTGAGTGAAAGATGG	MCPH1	ENSG00000147316	-0.24981597995364124	[77,60]	[63,46,90]	-3	hSpCas9	negative selection	5251999
6444748	6444770	8	-	27760321	HT29	viability after 13 days	GGGTCTTGAATGTATCAAAAGG	MCPH1	ENSG00000147316	-0.029442050001222242	[53,41]	[18,111,33]	0	hSpCas9	negative selection	5252000
6414793	6414815	8	+	27760321	HT29	viability after 10 days	CTCACGTTATCTTCAAAGATGG	MCPH1	ENSG00000147316	-0.39222154739972126	[94,73]	[68,82,88]	-5	hSpCas9	negative selection	5335459
6414809	6414831	8	+	27760321	HT29	viability after 10 days	AGATGGCTACCAGAGCACTTGG	MCPH1	ENSG00000147316	0.2463605626663778	[352,275]	[495,282,609]	3	hSpCas9	negative selection	5335460
6444390	6444412	8	+	27760321	HT29	viability after 10 days	CAGATGAATACTTTGCTGGTGG	MCPH1	ENSG00000147316	0.03707121417569273	[447,349]	[691,601,247]	0	hSpCas9	negative selection	5335461
6444554	6444576	8	-	27760321	HT29	viability after 10 days	TATCGAGGTGAGTGAAAGATGG	MCPH1	ENSG00000147316	0.13843081725927275	[77,60]	[22,236,31]	1	hSpCas9	negative selection	5335462
6444748	6444770	8	-	27760321	HT29	viability after 10 days	GGGTCTTGAATGTATCAAAAGG	MCPH1	ENSG00000147316	0.035625712439586454	[53,41]	[44,63,74]	0	hSpCas9	negative selection	5335463
6414793	6414815	8	+	27760321	MOLM13	viability	CTCACGTTATCTTCAAAGATGG	MCPH1	ENSG00000147316	-1.4024018398277298	[111,94]	[41,4]	-7	hSpCas9	negative selection	5418922
6414809	6414831	8	+	27760321	MOLM13	viability	AGATGGCTACCAGAGCACTTGG	MCPH1	ENSG00000147316	-1.8115158828927265	[397,352]	[2,108]	-7	hSpCas9	negative selection	5418923
6444390	6444412	8	+	27760321	MOLM13	viability	CAGATGAATACTTTGCTGGTGG	MCPH1	ENSG00000147316	0.8267510150603703	[578,447]	[480,534]	6	hSpCas9	negative selection	5418924
6444554	6444576	8	-	27760321	MOLM13	viability	TATCGAGGTGAGTGAAAGATGG	MCPH1	ENSG00000147316	0.9921003772521493	[94,77]	[0,177]	7	hSpCas9	negative selection	5418925
6444748	6444770	8	-	27760321	MOLM13	viability	GGGTCTTGAATGTATCAAAAGG	MCPH1	ENSG00000147316	1.585462850409176	[31,53]	[160,0]	9	hSpCas9	negative selection	5418926
6406673	6406696	8	+	27661255	K562	viability	GGCCCCCATCCTGAAAGGTGAGG	MCPH1	ENSG00000147316	-0.3785582727957002	[330,339]	[245,171]	-7	dCas9-KRAB	negative selection	5492678
6406753	6406776	8	+	27661255	K562	viability	GGCGCACTCGGGGGATCCCGTGG	MCPH1	ENSG00000147316	-0.4789381822485013	[655,695]	[487,300]	-7	dCas9-KRAB	negative selection	5492679
6406655	6406678	8	-	27661255	K562	viability	GGGCCGCCATGACAGACGGCGGG	MCPH1	ENSG00000147316	-0.08552371505824699	[708,777]	[554,561]	-3	dCas9-KRAB	negative selection	5492680
6407012	6407035	8	-	27661255	K562	viability	GCAGGCAGCGGGGGATTGAGGGG	MCPH1	ENSG00000147316	0.10709517136763966	[609,782]	[703,504]	4	dCas9-KRAB	negative selection	5492681
6414853	6414876	8	+	27260156	BXPC3	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.44836355876124345	[279]	[358,397,388,460]	8	hSpCas9	negative selection	5554765
6409282	6409305	8	+	27260156	BXPC3	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.3006898448617653	[527]	[390,481,458,463]	-6	hSpCas9	negative selection	5554766
6409334	6409357	8	+	27260156	BXPC3	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.5164844168489637	[545]	[725,615,1032,924]	9	hSpCas9	negative selection	5554767
6431539	6431562	8	-	27260156	BXPC3	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	-0.17290770344037443	[900]	[736,796,936,886]	-4	hSpCas9	negative selection	5619023
6414818	6414841	8	-	27260156	BXPC3	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.158811972934221	[172]	[114,189,165,181]	-4	hSpCas9	negative selection	5619024
6431491	6431514	8	+	27260156	BXPC3	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.24748211000604015	[845]	[635,821,607,937]	-5	hSpCas9	negative selection	5619025
6414853	6414876	8	+	27260156	A673	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.3593001168964518	[279]	[509,449,395,373]	8	hSpCas9	negative selection	5676016
6409282	6409305	8	+	27260156	A673	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.036137969988085133	[527]	[658,601,601,613]	-1	hSpCas9	negative selection	5676017
6409334	6409357	8	+	27260156	A673	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.28205245841510845	[545]	[911,858,721,700]	6	hSpCas9	negative selection	5676018
6431539	6431562	8	-	27260156	A673	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	-0.08836055626035744	[900]	[1190,984,812,1106]	-2	hSpCas9	negative selection	5740274
6414818	6414841	8	-	27260156	A673	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.09032293253717993	[172]	[148,197,178,251]	-2	hSpCas9	negative selection	5740275
6431491	6431514	8	+	27260156	A673	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.2870070283799273	[845]	[954,924,762,689]	-6	hSpCas9	negative selection	5740276
6414853	6414876	8	+	27260156	A375	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.23316066445461325	[279]	[270,583,424,293]	3	hSpCas9	negative selection	5797267
6409282	6409305	8	+	27260156	A375	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.764808025145013	[527]	[253,497,303,406]	-7	hSpCas9	negative selection	5797268
6409334	6409357	8	+	27260156	A375	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.16945555805091095	[545]	[673,1041,866,369]	2	hSpCas9	negative selection	5797269
6431539	6431562	8	-	27260156	A375	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	-0.10566626299663162	[900]	[971,1105,813,1027]	-1	hSpCas9	negative selection	5861525
6414818	6414841	8	-	27260156	A375	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.9972119220825846	[172]	[63,105,189,50]	-8	hSpCas9	negative selection	5861526
6431491	6431514	8	+	27260156	A375	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.47407654749412204	[845]	[735,696,872,553]	-6	hSpCas9	negative selection	5861527
6414853	6414876	8	+	27260156	COLO741	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.36133727350756506	[279]	[555,471,364]	7	hSpCas9	negative selection	5918518
6409282	6409305	8	+	27260156	COLO741	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	0.10914188631611346	[527]	[695,842,645]	2	hSpCas9	negative selection	5918519
6409334	6409357	8	+	27260156	COLO741	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.4621240522150847	[545]	[1033,975,882]	8	hSpCas9	negative selection	5918520
6431539	6431562	8	-	27260156	COLO741	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	0.083916923209575	[900]	[1277,961,1407]	1	hSpCas9	negative selection	5982776
6414818	6414841	8	-	27260156	COLO741	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	0.008874977482574264	[172]	[230,207,227]	0	hSpCas9	negative selection	5982777
6431491	6431514	8	+	27260156	COLO741	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.3053458526310112	[845]	[903,877,844]	-6	hSpCas9	negative selection	5982778
6414853	6414876	8	+	27260156	CAL120	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.5638662583936356	[279]	[677,461,430]	8	hSpCas9	negative selection	6039769
6409282	6409305	8	+	27260156	CAL120	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.847331566847149	[527]	[388,344,364]	-8	hSpCas9	negative selection	6039770
6409334	6409357	8	+	27260156	CAL120	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.3850251191757146	[545]	[794,1046,806]	6	hSpCas9	negative selection	6039771
6431539	6431562	8	-	27260156	CAL120	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	0.34688966583292424	[900]	[1177,1414,1642]	5	hSpCas9	negative selection	6104027
6414818	6414841	8	-	27260156	CAL120	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.6236014612727412	[172]	[278,72,88]	-7	hSpCas9	negative selection	6104028
6431491	6431514	8	+	27260156	CAL120	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.07222031243458404	[845]	[789,1133,1046]	-1	hSpCas9	negative selection	6104029
6414853	6414876	8	+	27260156	CADOES1	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	-0.06073323452653401	[279]	[235,226,252,283]	-1	hSpCas9	negative selection	6161020
6409282	6409305	8	+	27260156	CADOES1	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.1720512401648378	[527]	[301,523,353,568]	-3	hSpCas9	negative selection	6161021
6409334	6409357	8	+	27260156	CADOES1	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.79375466928917	[545]	[861,1035,761,860]	9	hSpCas9	negative selection	6161022
6431539	6431562	8	-	27260156	CADOES1	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	0.25812783593706856	[900]	[877,985,1063,1083]	4	hSpCas9	negative selection	6225278
6414818	6414841	8	-	27260156	CADOES1	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.301047170459269	[172]	[125,131,143,119]	-5	hSpCas9	negative selection	6225279
6431491	6431514	8	+	27260156	CADOES1	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.38733293137595187	[845]	[601,630,528,645]	-6	hSpCas9	negative selection	6225280
6414853	6414876	8	+	27260156	EWS502	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.2864444313382431	[279]	[346,341,421,335]	5	hSpCas9	negative selection	6282271
6409282	6409305	8	+	27260156	EWS502	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.4199637994473022	[527]	[498,382,508,260]	-6	hSpCas9	negative selection	6282272
6409334	6409357	8	+	27260156	EWS502	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.6265958794749749	[545]	[641,920,996,1049]	9	hSpCas9	negative selection	6282273
6431539	6431562	8	-	27260156	EWS502	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	-0.11826213749418013	[900]	[876,828,1002,802]	-2	hSpCas9	negative selection	6346529
6414818	6414841	8	-	27260156	EWS502	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.2139445002200806	[172]	[135,231,155,102]	-4	hSpCas9	negative selection	6346530
6431491	6431514	8	+	27260156	EWS502	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.20921504718495998	[845]	[840,666,767,820]	-4	hSpCas9	negative selection	6346531
6414853	6414876	8	+	27260156	EW8	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.21874319375839602	[279]	[313,266,186,305]	4	hSpCas9	negative selection	6403522
6409282	6409305	8	+	27260156	EW8	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.039976569219169034	[527]	[386,479,378,420]	0	hSpCas9	negative selection	6403523
6409334	6409357	8	+	27260156	EW8	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.4835848829048599	[545]	[616,504,641,703]	8	hSpCas9	negative selection	6403524
6431539	6431562	8	-	27260156	EW8	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	0.17398649835941915	[900]	[890,857,766,793]	3	hSpCas9	negative selection	6467780
6414818	6414841	8	-	27260156	EW8	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	0.22236799149604036	[172]	[138,235,160,115]	4	hSpCas9	negative selection	6467781
6431491	6431514	8	+	27260156	EW8	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.44144945748345477	[845]	[607,590,404,442]	-7	hSpCas9	negative selection	6467782
6414853	6414876	8	+	27260156	CORL105	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	-0.1424424860829182	[279]	[184,335,353,316]	-3	hSpCas9	negative selection	6524773
6409282	6409305	8	+	27260156	CORL105	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.34905536957955835	[527]	[538,292,628,507]	-6	hSpCas9	negative selection	6524774
6409334	6409357	8	+	27260156	CORL105	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.11194127426737627	[545]	[641,685,846,610]	2	hSpCas9	negative selection	6524775
6431539	6431562	8	-	27260156	CORL105	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	-0.20611893632751865	[900]	[737,930,1088,919]	-4	hSpCas9	negative selection	6589031
6414818	6414841	8	-	27260156	CORL105	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.08494791050774331	[172]	[227,174,250,120]	-1	hSpCas9	negative selection	6589032
6431491	6431514	8	+	27260156	CORL105	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.4118012523067876	[845]	[690,745,959,612]	-6	hSpCas9	negative selection	6589033
6414853	6414876	8	+	27260156	HS294T	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.6708454366388402	[279]	[197,189,123,173]	8	hSpCas9	negative selection	6646024
6409282	6409305	8	+	27260156	HS294T	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.3297101931865771	[527]	[189,141,163,148]	-5	hSpCas9	negative selection	6646025
6409334	6409357	8	+	27260156	HS294T	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.32600261830974775	[545]	[201,302,299,255]	4	hSpCas9	negative selection	6646026
6431539	6431562	8	-	27260156	HS294T	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	-0.1761135976570033	[900]	[298,380,255,291]	-2	hSpCas9	negative selection	6710282
6414818	6414841	8	-	27260156	HS294T	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.5634566219268589	[172]	[33,43,58,44]	-7	hSpCas9	negative selection	6710283
6431491	6431514	8	+	27260156	HS294T	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	0.47352690025144295	[845]	[604,467,397,303]	6	hSpCas9	negative selection	6710284
6414853	6414876	8	+	27260156	HCC44	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	-0.05342368864308211	[279]	[197,340,377,298]	-1	hSpCas9	negative selection	6767275
6409282	6409305	8	+	27260156	HCC44	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.4257616136065736	[527]	[563,338,673,268]	-6	hSpCas9	negative selection	6767276
6409334	6409357	8	+	27260156	HCC44	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.46614101195905344	[545]	[909,844,997,688]	7	hSpCas9	negative selection	6767277
6431539	6431562	8	-	27260156	HCC44	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	0.036969461667560766	[900]	[1307,777,1408,810]	0	hSpCas9	negative selection	6831533
6414818	6414841	8	-	27260156	HCC44	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.3712549249531971	[172]	[72,248,175,90]	-5	hSpCas9	negative selection	6831534
6431491	6431514	8	+	27260156	HCC44	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.34763358776587716	[845]	[1020,622,887,542]	-5	hSpCas9	negative selection	6831535
6414853	6414876	8	+	27260156	G402	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.3808051670714239	[279]	[828,497,206,308]	5	hSpCas9	negative selection	6888526
6409282	6409305	8	+	27260156	G402	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.7745959693774125	[527]	[379,264,583,274]	-7	hSpCas9	negative selection	6888527
6409334	6409357	8	+	27260156	G402	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.6446800356498079	[545]	[1044,1304,890,941]	7	hSpCas9	negative selection	6888528
6431539	6431562	8	-	27260156	G402	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	0.20920582785064423	[900]	[1070,1571,1226,1200]	2	hSpCas9	negative selection	6952784
6414818	6414841	8	-	27260156	G402	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.15377145757114952	[172]	[168,166,207,208]	-2	hSpCas9	negative selection	6952785
6431491	6431514	8	+	27260156	G402	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.21943946041607654	[845]	[1353,885,641,735]	-3	hSpCas9	negative selection	6952786
6414853	6414876	8	+	27260156	L33	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.024732270613632257	[279]	[236,100,235,281]	0	hSpCas9	negative selection	7009777
6409282	6409305	8	+	27260156	L33	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.14117737560977384	[527]	[486,172,297,530]	-3	hSpCas9	negative selection	7009778
6409334	6409357	8	+	27260156	L33	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.45800813810658725	[545]	[668,342,390,871]	8	hSpCas9	negative selection	7009779
6431539	6431562	8	-	27260156	L33	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	-0.24211036804678554	[900]	[635,357,482,771]	-5	hSpCas9	negative selection	7074035
6414818	6414841	8	-	27260156	L33	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.11714661205410581	[172]	[195,41,140,114]	-3	hSpCas9	negative selection	7074036
6431491	6431514	8	+	27260156	L33	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.3119991940010882	[845]	[771,260,399,677]	-6	hSpCas9	negative selection	7074037
6414853	6414876	8	+	27260156	K562	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.47048576824793503	[279]	[322,172,279,562]	6	hSpCas9	negative selection	7131028
6409282	6409305	8	+	27260156	K562	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.2640810685675231	[527]	[444,304,502,314]	-3	hSpCas9	negative selection	7131029
6409334	6409357	8	+	27260156	K562	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.41707110202786235	[545]	[848,771,630,386]	5	hSpCas9	negative selection	7131030
6431539	6431562	8	-	27260156	K562	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	0.13771685567237857	[900]	[656,1159,914,789]	1	hSpCas9	negative selection	7195286
6414818	6414841	8	-	27260156	K562	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.04745420832013103	[172]	[232,128,140,101]	0	hSpCas9	negative selection	7195287
6431491	6431514	8	+	27260156	K562	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.10497454407586759	[845]	[650,690,696,740]	-1	hSpCas9	negative selection	7195288
6414853	6414876	8	+	27260156	HT29	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.29506825286913474	[279]	[481,295,457,424]	6	hSpCas9	negative selection	7252279
6409282	6409305	8	+	27260156	HT29	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.38783140492546775	[527]	[355,575,446,566]	-6	hSpCas9	negative selection	7252280
6409334	6409357	8	+	27260156	HT29	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.5546295120306317	[545]	[999,1069,1005,842]	9	hSpCas9	negative selection	7252281
6431539	6431562	8	-	27260156	HT29	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	0.031285870579654596	[900]	[1522,1033,1034,924]	0	hSpCas9	negative selection	7316537
6414818	6414841	8	-	27260156	HT29	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	0.07920650754557945	[172]	[188,244,261,193]	1	hSpCas9	negative selection	7316538
6431491	6431514	8	+	27260156	HT29	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.2621510214622492	[845]	[916,930,919,687]	-5	hSpCas9	negative selection	7316539
6414853	6414876	8	+	27260156	MHHES1	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.2615363806617821	[279]	[536,403,199,381]	5	hSpCas9	negative selection	7373530
6409282	6409305	8	+	27260156	MHHES1	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.30764643158890037	[527]	[369,449,523,536]	-5	hSpCas9	negative selection	7373531
6409334	6409357	8	+	27260156	MHHES1	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.12175102288449963	[545]	[712,940,668,427]	2	hSpCas9	negative selection	7373532
6431539	6431562	8	-	27260156	MHHES1	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	-0.2781446903487145	[900]	[751,924,881,780]	-5	hSpCas9	negative selection	7437788
6414818	6414841	8	-	27260156	MHHES1	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.3348790651457041	[172]	[141,136,196,138]	-6	hSpCas9	negative selection	7437789
6431491	6431514	8	+	27260156	MHHES1	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.4270164772120652	[845]	[797,814,766,507]	-7	hSpCas9	negative selection	7437790
6414853	6414876	8	+	27260156	MEWO	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.11223810355401165	[279]	[264,256,323]	2	hSpCas9	negative selection	7494781
6409282	6409305	8	+	27260156	MEWO	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.7558971053851872	[527]	[381,258,253]	-9	hSpCas9	negative selection	7494782
6409334	6409357	8	+	27260156	MEWO	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.3879398991369779	[545]	[914,436,701]	7	hSpCas9	negative selection	7494783
6431539	6431562	8	-	27260156	MEWO	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	-0.28019280265112456	[900]	[670,857,547]	-6	hSpCas9	negative selection	7559039
6414818	6414841	8	-	27260156	MEWO	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.46452736925079385	[172]	[102,135,109]	-7	hSpCas9	negative selection	7559040
6431491	6431514	8	+	27260156	MEWO	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.18522884742528656	[845]	[828,684,599]	-4	hSpCas9	negative selection	7559041
6414853	6414876	8	+	27260156	LNCAPCLONEFGC	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.4001262336931498	[279]	[348,268,437,301]	6	hSpCas9	negative selection	7616032
6409282	6409305	8	+	27260156	LNCAPCLONEFGC	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.4129170094982848	[527]	[473,225,410,339]	-6	hSpCas9	negative selection	7616033
6409334	6409357	8	+	27260156	LNCAPCLONEFGC	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.42937464202899966	[545]	[632,564,887,617]	6	hSpCas9	negative selection	7616034
6431539	6431562	8	-	27260156	LNCAPCLONEFGC	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	-0.22982737002978548	[900]	[742,600,804,655]	-4	hSpCas9	negative selection	7680290
6414818	6414841	8	-	27260156	LNCAPCLONEFGC	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.07118896212749748	[172]	[165,126,76,216]	-1	hSpCas9	negative selection	7680291
6431491	6431514	8	+	27260156	LNCAPCLONEFGC	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.42097012585432103	[845]	[535,550,724,501]	-6	hSpCas9	negative selection	7680292
6414853	6414876	8	+	27260156	PANC0327	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.3001144772603389	[279]	[274,284,296,367]	4	hSpCas9	negative selection	7737283
6409282	6409305	8	+	27260156	PANC0327	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-1.2311884949891678	[527]	[127,184,171,309]	-9	hSpCas9	negative selection	7737284
6409334	6409357	8	+	27260156	PANC0327	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.47417883034870567	[545]	[691,635,611,760]	7	hSpCas9	negative selection	7737285
6431539	6431562	8	-	27260156	PANC0327	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	-0.12168600482330427	[900]	[968,637,696,669]	-2	hSpCas9	negative selection	7801541
6414818	6414841	8	-	27260156	PANC0327	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	0.20922896289308812	[172]	[84,132,316,173]	3	hSpCas9	negative selection	7801542
6431491	6431514	8	+	27260156	PANC0327	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.4361844378870942	[845]	[704,343,536,674]	-6	hSpCas9	negative selection	7801543
6414853	6414876	8	+	27260156	NCIH2009	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.2170084955423347	[279]	[715,398,300]	3	hSpCas9	negative selection	7858534
6409282	6409305	8	+	27260156	NCIH2009	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.7495122967813141	[527]	[405,335,568]	-7	hSpCas9	negative selection	7858535
6409334	6409357	8	+	27260156	NCIH2009	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.1975600211287259	[545]	[946,774,916]	2	hSpCas9	negative selection	7858536
6431539	6431562	8	-	27260156	NCIH2009	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	-0.4684561459526352	[900]	[921,925,881]	-6	hSpCas9	negative selection	7922792
6414818	6414841	8	-	27260156	NCIH2009	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.7877724210894468	[172]	[139,182,95]	-7	hSpCas9	negative selection	7922793
6431491	6431514	8	+	27260156	NCIH2009	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.17578767393306283	[845]	[1286,769,1132]	-2	hSpCas9	negative selection	7922794
6414853	6414876	8	+	27260156	NCIH1373	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.630319941325557	[279]	[595,279,491,162]	6	hSpCas9	negative selection	7979785
6409282	6409305	8	+	27260156	NCIH1373	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	0.09735023561410885	[527]	[1104,282,589,174]	1	hSpCas9	negative selection	7979786
6409334	6409357	8	+	27260156	NCIH1373	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.9247222755906334	[545]	[1472,1180,951,283]	8	hSpCas9	negative selection	7979787
6431539	6431562	8	-	27260156	NCIH1373	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	0.32262931193293876	[900]	[2019,1046,1053,277]	3	hSpCas9	negative selection	8044043
6414818	6414841	8	-	27260156	NCIH1373	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.14923711537945872	[172]	[217,208,51,59]	-1	hSpCas9	negative selection	8044044
6431491	6431514	8	+	27260156	NCIH1373	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	0.14186764814280883	[845]	[789,713,1787,224]	1	hSpCas9	negative selection	8044045
6414853	6414876	8	+	27260156	PATU8902	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	-0.22923409116707527	[279]	[212,147,325,685]	-2	hSpCas9	negative selection	8101036
6409282	6409305	8	+	27260156	PATU8902	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.9173736055124045	[527]	[507,459,327,256]	-7	hSpCas9	negative selection	8101037
6409334	6409357	8	+	27260156	PATU8902	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	-0.20080676328890515	[545]	[639,514,612,915]	-2	hSpCas9	negative selection	8101038
6431539	6431562	8	-	27260156	PATU8902	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	-0.5633492536266544	[900]	[837,804,455,1466]	-5	hSpCas9	negative selection	8165294
6414818	6414841	8	-	27260156	PATU8902	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	0.08885915016321566	[172]	[81,226,489,152]	0	hSpCas9	negative selection	8165295
6431491	6431514	8	+	27260156	PATU8902	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.5602420625595195	[845]	[525,661,910,1100]	-5	hSpCas9	negative selection	8165296
6414853	6414876	8	+	27260156	PANC1	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.30581092360314027	[279]	[187,293,461,250]	5	hSpCas9	negative selection	8222287
6409282	6409305	8	+	27260156	PANC1	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.5930231507675531	[527]	[296,334,268,302]	-7	hSpCas9	negative selection	8222288
6409334	6409357	8	+	27260156	PANC1	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.5991639583437645	[545]	[617,656,890,663]	8	hSpCas9	negative selection	8222289
6431539	6431562	8	-	27260156	PANC1	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	-0.024343408236752517	[900]	[739,870,672,767]	0	hSpCas9	negative selection	8286545
6414818	6414841	8	-	27260156	PANC1	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.2076037238465267	[172]	[136,179,119,91]	-3	hSpCas9	negative selection	8286546
6431491	6431514	8	+	27260156	PANC1	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.45447051759871626	[845]	[583,798,376,422]	-6	hSpCas9	negative selection	8286547
6414853	6414876	8	+	27260156	PANC0813	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.08945292446135222	[279]	[533,276,395,216]	1	hSpCas9	negative selection	8343538
6409282	6409305	8	+	27260156	PANC0813	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-1.0424363439537712	[527]	[300,251,311,336]	-8	hSpCas9	negative selection	8343539
6409334	6409357	8	+	27260156	PANC0813	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.06793879328584956	[545]	[575,578,817,704]	1	hSpCas9	negative selection	8343540
6431539	6431562	8	-	27260156	PANC0813	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	-0.49441955661638315	[900]	[886,638,886,611]	-6	hSpCas9	negative selection	8407796
6414818	6414841	8	-	27260156	PANC0813	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-1.4385879585635926	[172]	[129,88,52,34]	-9	hSpCas9	negative selection	8407797
6431491	6431514	8	+	27260156	PANC0813	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.5487939228132109	[845]	[848,537,753,595]	-7	hSpCas9	negative selection	8407798
6414853	6414876	8	+	27260156	RDES	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.2714203744085888	[279]	[317,393,429,421]	4	hSpCas9	negative selection	8464789
6409282	6409305	8	+	27260156	RDES	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	0.1147620315936402	[527]	[464,573,702,968]	1	hSpCas9	negative selection	8464790
6409334	6409357	8	+	27260156	RDES	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.62674009987017	[545]	[896,921,881,1196]	8	hSpCas9	negative selection	8464791
6431539	6431562	8	-	27260156	RDES	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	0.13966035028214063	[900]	[945,996,1390,1284]	2	hSpCas9	negative selection	8529047
6414818	6414841	8	-	27260156	RDES	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.0759539490161385	[172]	[184,155,216,196]	-1	hSpCas9	negative selection	8529048
6431491	6431514	8	+	27260156	RDES	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.2776463247522577	[845]	[608,753,835,1077]	-5	hSpCas9	negative selection	8529049
6414853	6414876	8	+	27260156	PC3	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.07046603726826217	[279]	[135,250,636,333]	1	hSpCas9	negative selection	8586040
6409282	6409305	8	+	27260156	PC3	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.08094487514794797	[527]	[337,341,804,659]	-2	hSpCas9	negative selection	8586041
6409334	6409357	8	+	27260156	PC3	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.38777292130266927	[545]	[395,866,1100,700]	7	hSpCas9	negative selection	8586042
6431539	6431562	8	-	27260156	PC3	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	-0.23830670078907545	[900]	[377,817,1184,940]	-5	hSpCas9	negative selection	8650298
6414818	6414841	8	-	27260156	PC3	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.17655828949216001	[172]	[103,116,306,149]	-4	hSpCas9	negative selection	8650299
6431491	6431514	8	+	27260156	PC3	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.15462694923428466	[845]	[473,684,1504,710]	-3	hSpCas9	negative selection	8650300
6414853	6414876	8	+	27260156	PATU8988T	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.17964902641135405	[279]	[248,400,150,446]	3	hSpCas9	negative selection	8707291
6409282	6409305	8	+	27260156	PATU8988T	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.866846394789998	[527]	[244,284,280,310]	-8	hSpCas9	negative selection	8707292
6409334	6409357	8	+	27260156	PATU8988T	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.34550055803238355	[545]	[726,606,713,622]	6	hSpCas9	negative selection	8707293
6431539	6431562	8	-	27260156	PATU8988T	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	-0.2717986075452201	[900]	[597,880,666,756]	-4	hSpCas9	negative selection	8771549
6414818	6414841	8	-	27260156	PATU8988T	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.20438329627054563	[172]	[151,20,241,152]	-3	hSpCas9	negative selection	8771550
6431491	6431514	8	+	27260156	PATU8988T	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.24832755373726523	[845]	[619,680,693,762]	-4	hSpCas9	negative selection	8771551
6414853	6414876	8	+	27260156	T47D	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.3442093283273802	[279]	[430,329,435,467]	7	hSpCas9	negative selection	8828542
6409282	6409305	8	+	27260156	T47D	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.050138589724606414	[527]	[555,549,567,709]	-1	hSpCas9	negative selection	8828543
6409334	6409357	8	+	27260156	T47D	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.6080382987158433	[545]	[978,929,974,997]	9	hSpCas9	negative selection	8828544
6431539	6431562	8	-	27260156	T47D	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	0.027564685605086625	[900]	[1091,1110,1039,1031]	0	hSpCas9	negative selection	8892800
6414818	6414841	8	-	27260156	T47D	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.24624475704755389	[172]	[147,188,187,151]	-5	hSpCas9	negative selection	8892801
6431491	6431514	8	+	27260156	T47D	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.13432552928287333	[845]	[730,1021,877,950]	-3	hSpCas9	negative selection	8892802
6414853	6414876	8	+	27260156	SU8686	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.36077196362084374	[279]	[296,309,378,468]	6	hSpCas9	negative selection	8949793
6409282	6409305	8	+	27260156	SU8686	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.4298817406084766	[527]	[305,285,382,639]	-6	hSpCas9	negative selection	8949794
6409334	6409357	8	+	27260156	SU8686	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.3709624861333989	[545]	[729,571,791,719]	6	hSpCas9	negative selection	8949795
6431539	6431562	8	-	27260156	SU8686	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	-0.10269146990247302	[900]	[770,694,882,1030]	-2	hSpCas9	negative selection	9014051
6414818	6414841	8	-	27260156	SU8686	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.23394477375172706	[172]	[148,102,176,161]	-4	hSpCas9	negative selection	9014052
6431491	6431514	8	+	27260156	SU8686	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.6285568853965544	[845]	[496,483,596,613]	-7	hSpCas9	negative selection	9014053
6414853	6414876	8	+	27260156	SKES1	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.13151869959122375	[279]	[396,275,309,252]	3	hSpCas9	negative selection	9071044
6409282	6409305	8	+	27260156	SKES1	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.2793989933430448	[527]	[451,450,375,454]	-6	hSpCas9	negative selection	9071045
6409334	6409357	8	+	27260156	SKES1	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.48546838955523397	[545]	[820,1045,704,539]	8	hSpCas9	negative selection	9071046
6431539	6431562	8	-	27260156	SKES1	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	-0.1100748950699052	[900]	[869,854,920,698]	-2	hSpCas9	negative selection	9135302
6414818	6414841	8	-	27260156	SKES1	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.1610890466639756	[172]	[191,168,62,194]	-4	hSpCas9	negative selection	9135303
6431491	6431514	8	+	27260156	SKES1	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.21258680833760935	[845]	[960,802,506,683]	-5	hSpCas9	negative selection	9135304
6414853	6414876	8	+	27260156	TOV112D	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.030570854415086335	[279]	[343,345,195,278]	0	hSpCas9	negative selection	9192295
6409282	6409305	8	+	27260156	TOV112D	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.5550761099168328	[527]	[287,575,217,402]	-8	hSpCas9	negative selection	9192296
6409334	6409357	8	+	27260156	TOV112D	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.017860796423465247	[545]	[439,879,502,463]	0	hSpCas9	negative selection	9192297
6431539	6431562	8	-	27260156	TOV112D	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	0.28229249435762227	[900]	[1162,1606,947,808]	5	hSpCas9	negative selection	9256553
6414818	6414841	8	-	27260156	TOV112D	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.8367110558001998	[172]	[69,203,114,24]	-9	hSpCas9	negative selection	9256554
6431491	6431514	8	+	27260156	TOV112D	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.29295690655845985	[845]	[830,819,480,676]	-5	hSpCas9	negative selection	9256555
6414853	6414876	8	+	27260156	TC71	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	0.2587000502244516	[279]	[231,442,360,405]	6	hSpCas9	negative selection	9313546
6409282	6409305	8	+	27260156	TC71	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.45277159190826455	[527]	[330,401,524,392]	-8	hSpCas9	negative selection	9313547
6409334	6409357	8	+	27260156	TC71	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.3291838304786744	[545]	[754,695,773,712]	7	hSpCas9	negative selection	9313548
6431539	6431562	8	-	27260156	TC71	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	0.028919188169011734	[900]	[953,1027,1058,892]	0	hSpCas9	negative selection	9377804
6414818	6414841	8	-	27260156	TC71	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.11095429486247865	[172]	[91,213,143,243]	-3	hSpCas9	negative selection	9377805
6431491	6431514	8	+	27260156	TC71	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.3082274510702411	[845]	[745,715,696,773]	-7	hSpCas9	negative selection	9377806
6414853	6414876	8	+	27260156	TC32	viability	TAAAGCTCGTTTCGGTGCTCTGG	MCPH1	ENSG00000147316	-0.09386193664722697	[279]	[292,130,339,262]	-2	hSpCas9	negative selection	9434797
6409282	6409305	8	+	27260156	TC32	viability	TAGTGGCCTATGTTGAAGTGTGG	MCPH1	ENSG00000147316	-0.28114140888867434	[527]	[416,311,508,423]	-5	hSpCas9	negative selection	9434798
6409334	6409357	8	+	27260156	TC32	viability	GACATTTACAACACAGCTTGTGG	MCPH1	ENSG00000147316	0.01791288307512362	[545]	[423,304,849,627]	0	hSpCas9	negative selection	9434799
6431539	6431562	8	-	27260156	TC32	viability	TGTTCATTCATATTAGCTGCAGG	MCPH1	ENSG00000147316	-0.039960916075169384	[900]	[672,554,1341,892]	0	hSpCas9	negative selection	9499055
6414818	6414841	8	-	27260156	TC32	viability	GAGCTTTGTCCCAAGTGCTCTGG	MCPH1	ENSG00000147316	-0.3423928958299194	[172]	[75,103,227,130]	-6	hSpCas9	negative selection	9499056
6431491	6431514	8	+	27260156	TC32	viability	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.21199789908053857	[845]	[602,650,659,813]	-4	hSpCas9	negative selection	9499057
6406678	6406701	8	-	27869803	HPAFII	viability after 27 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-1.5207959757525984	[64]	[24,0,NaN]	-7	hSpCas9	negative selection	9602975
6431491	6431514	8	+	27869803	HPAFII	viability after 27 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-1.111210958753374	[256]	[85,42,NaN]	-6	hSpCas9	negative selection	9602976
6445237	6445260	8	+	27869803	HPAFII	viability after 27 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	0.00549331622682267	[230]	[50,180,NaN]	0	hSpCas9	negative selection	9602977
6480811	6480834	8	-	27869803	HPAFII	viability after 27 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	-2.3874612549264187	[37]	[5,1,NaN]	-8	hSpCas9	negative selection	9602978
6406678	6406701	8	-	27869803	HPAFII	viability after 15 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-0.4515696500887372	[64]	[47,52,NaN]	-5	hSpCas9	negative selection	9685424
6431491	6431514	8	+	27869803	HPAFII	viability after 15 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.5939686392730652	[256]	[264,131,NaN]	-6	hSpCas9	negative selection	9685425
6445237	6445260	8	+	27869803	HPAFII	viability after 15 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	0.201400394048997	[230]	[171,355,NaN]	2	hSpCas9	negative selection	9685426
6480811	6480834	8	-	27869803	HPAFII	viability after 15 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	-1.432154078138594	[37]	[24,8,NaN]	-8	hSpCas9	negative selection	9685427
6406678	6406701	8	-	27869803	ASPC1	viability after 36 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	0.6386732192081961	[214]	[126,153,78]	6	hSpCas9	negative selection	9767873
6431491	6431514	8	+	27869803	ASPC1	viability after 36 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	0.12349688752199933	[718]	[321,307,208]	1	hSpCas9	negative selection	9767874
6445237	6445260	8	+	27869803	ASPC1	viability after 36 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	0.20270712192119142	[658]	[246,166,351]	2	hSpCas9	negative selection	9767875
6480811	6480834	8	-	27869803	ASPC1	viability after 36 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	-0.03233418354685558	[113]	[83,5,32]	0	hSpCas9	negative selection	9767876
6406678	6406701	8	-	27869803	PATU8988S	viability after 35 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-1.713448062971179	[243]	[14,44,NaN]	-8	hSpCas9	negative selection	9850322
6431491	6431514	8	+	27869803	PATU8988S	viability after 35 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.6760044016221777	[554]	[97,181,NaN]	-6	hSpCas9	negative selection	9850323
6445237	6445260	8	+	27869803	PATU8988S	viability after 35 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	0.4360270821730233	[595]	[430,217,NaN]	5	hSpCas9	negative selection	9850324
6480811	6480834	8	-	27869803	PATU8988S	viability after 35 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	0.0395076820949658	[80]	[45,20,NaN]	0	hSpCas9	negative selection	9850325
6406678	6406701	8	-	27869803	PATU8988S	viability after 31 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-2.568726029255215	[243]	[11,21,NaN]	-9	hSpCas9	negative selection	9932771
6431491	6431514	8	+	27869803	PATU8988S	viability after 31 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-0.4939022478133298	[554]	[95,234,NaN]	-5	hSpCas9	negative selection	9932772
6445237	6445260	8	+	27869803	PATU8988S	viability after 31 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	0.12836991701460665	[595]	[290,219,NaN]	1	hSpCas9	negative selection	9932773
6480811	6480834	8	-	27869803	PATU8988S	viability after 31 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	0.526444198985176	[80]	[53,36,NaN]	6	hSpCas9	negative selection	9932774
6406678	6406701	8	-	27869803	HPAFII	viability after 35 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-1.9981332724475815	[64]	[11,3,NaN]	-7	hSpCas9	negative selection	10015220
6431491	6431514	8	+	27869803	HPAFII	viability after 35 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-1.5239736793425442	[256]	[56,31,NaN]	-7	hSpCas9	negative selection	10015221
6445237	6445260	8	+	27869803	HPAFII	viability after 35 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	-0.4810135285018839	[230]	[8,167,NaN]	-3	hSpCas9	negative selection	10015222
6480811	6480834	8	-	27869803	HPAFII	viability after 35 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	-2.4707554056058623	[37]	[2,3,NaN]	-8	hSpCas9	negative selection	10015223
6406678	6406701	8	-	27869803	HPAFII	viability after 31 days	AAGTACCTCACCTTTCAGGATGG	MCPH1	ENSG00000147316	-0.7300334782533464	[64]	[32,9,NaN]	-5	hSpCas9	negative selection	10097669
6431491	6431514	8	+	27869803	HPAFII	viability after 31 days	TTATACAGATGCAGGACAGCTGG	MCPH1	ENSG00000147316	-1.1405619915356509	[256]	[85,42,NaN]	-6	hSpCas9	negative selection	10097670
6445237	6445260	8	+	27869803	HPAFII	viability after 31 days	AGCCCTAAGGTGTTGTAGACAGG	MCPH1	ENSG00000147316	-0.09153122424021846	[230]	[24,226,NaN]	0	hSpCas9	negative selection	10097671
6480811	6480834	8	-	27869803	HPAFII	viability after 31 days	AGCACATTCAGGGTGCGAAGTGG	MCPH1	ENSG00000147316	-3.809129710487456	[37]	[1,0,NaN]	-9	hSpCas9	negative selection	10097672
6445514	6445537	8	+	28162770	P31FUJ	viability	GAGAAGGAAAACTTACCCGGAGG	MCPH1	ENSG00000147316	-0.5873349647336684	[178]	[139]	-5	hSpCas9	negative selection	10190300
6444852	6444875	8	+	28162770	P31FUJ	viability	CCAGGAGATCTATCATGCCGAGG	MCPH1	ENSG00000147316	-0.14194877396326505	[199]	[212]	-1	hSpCas9	negative selection	10190301
6444895	6444918	8	+	28162770	P31FUJ	viability	AGACAGGCTGCAGCACGTGGCGG	MCPH1	ENSG00000147316	0.9247390725721014	[25]	[57]	9	hSpCas9	negative selection	10190302
6444923	6444946	8	+	28162770	P31FUJ	viability	GCCCTGGAGGCTCTTAGCTGTGG	MCPH1	ENSG00000147316	0.48340482958503006	[83]	[137]	5	hSpCas9	negative selection	10190303
6445010	6445033	8	-	28162770	P31FUJ	viability	GATGGCAGCTGAGATTCAGGAGG	MCPH1	ENSG00000147316	0.22478098983054973	[141]	[194]	2	hSpCas9	negative selection	10190304
6445264	6445287	8	+	28162770	P31FUJ	viability	GAAAGAAGACGCATGCCCAGAGG	MCPH1	ENSG00000147316	0.07012492854292807	[213]	[263]	0	hSpCas9	negative selection	10190305
6445370	6445393	8	+	28162770	P31FUJ	viability	GAAGAAATGAAAGAAGCGGTTGG	MCPH1	ENSG00000147316	-0.012203064900981442	[114]	[133]	0	hSpCas9	negative selection	10190306
6445394	6445417	8	+	28162770	P31FUJ	viability	CTGAAAAGCACACAGAACAAAGG	MCPH1	ENSG00000147316	0.17846551210574169	[478]	[636]	1	hSpCas9	negative selection	10190307
6445498	6445521	8	+	28162770	P31FUJ	viability	GGAGACGTCTACAGAAGAGAAGG	MCPH1	ENSG00000147316	-0.3371388642291142	[85]	[79]	-3	hSpCas9	negative selection	10190308
6409288	6409311	8	-	28162770	P31FUJ	viability	GGATGACCACACTTCAACATAGG	MCPH1	ENSG00000147316	-1.132860766540472	[473]	[253]	-7	hSpCas9	negative selection	10190309
6445514	6445537	8	+	28162770	TF1	viability	GAGAAGGAAAACTTACCCGGAGG	MCPH1	ENSG00000147316	NaN	[NaN]	[131]	1	hSpCas9	negative selection	10359666
6444852	6444875	8	+	28162770	TF1	viability	CCAGGAGATCTATCATGCCGAGG	MCPH1	ENSG00000147316	NaN	[NaN]	[250]	1	hSpCas9	negative selection	10359667
6444895	6444918	8	+	28162770	TF1	viability	AGACAGGCTGCAGCACGTGGCGG	MCPH1	ENSG00000147316	NaN	[NaN]	[82]	1	hSpCas9	negative selection	10359668
6444923	6444946	8	+	28162770	TF1	viability	GCCCTGGAGGCTCTTAGCTGTGG	MCPH1	ENSG00000147316	NaN	[NaN]	[106]	1	hSpCas9	negative selection	10359669
6445010	6445033	8	-	28162770	TF1	viability	GATGGCAGCTGAGATTCAGGAGG	MCPH1	ENSG00000147316	NaN	[NaN]	[54]	1	hSpCas9	negative selection	10359670
6445264	6445287	8	+	28162770	TF1	viability	GAAAGAAGACGCATGCCCAGAGG	MCPH1	ENSG00000147316	NaN	[NaN]	[212]	1	hSpCas9	negative selection	10359671
6445370	6445393	8	+	28162770	TF1	viability	GAAGAAATGAAAGAAGCGGTTGG	MCPH1	ENSG00000147316	NaN	[NaN]	[87]	1	hSpCas9	negative selection	10359672
6445394	6445417	8	+	28162770	TF1	viability	CTGAAAAGCACACAGAACAAAGG	MCPH1	ENSG00000147316	NaN	[NaN]	[895]	1	hSpCas9	negative selection	10359673
6445498	6445521	8	+	28162770	TF1	viability	GGAGACGTCTACAGAAGAGAAGG	MCPH1	ENSG00000147316	NaN	[NaN]	[82]	1	hSpCas9	negative selection	10359674
6409288	6409311	8	-	28162770	TF1	viability	GGATGACCACACTTCAACATAGG	MCPH1	ENSG00000147316	NaN	[NaN]	[291]	1	hSpCas9	negative selection	10359675
6445514	6445537	8	+	28162770	SKM1	viability	GAGAAGGAAAACTTACCCGGAGG	MCPH1	ENSG00000147316	-0.9740047914670555	[49]	[44]	-6	hSpCas9	negative selection	10529032
6444852	6444875	8	+	28162770	SKM1	viability	CCAGGAGATCTATCATGCCGAGG	MCPH1	ENSG00000147316	-0.7109703856332619	[49]	[53]	-5	hSpCas9	negative selection	10529033
6444895	6444918	8	+	28162770	SKM1	viability	AGACAGGCTGCAGCACGTGGCGG	MCPH1	ENSG00000147316	1.6374299206152916	[9]	[54]	9	hSpCas9	negative selection	10529034
6444923	6444946	8	+	28162770	SKM1	viability	GCCCTGGAGGCTCTTAGCTGTGG	MCPH1	ENSG00000147316	0.41065905876826947	[39]	[93]	4	hSpCas9	negative selection	10529035
6445010	6445033	8	-	28162770	SKM1	viability	GATGGCAGCTGAGATTCAGGAGG	MCPH1	ENSG00000147316	-0.11938760864657641	[50]	[82]	-1	hSpCas9	negative selection	10529036
6445264	6445287	8	+	28162770	SKM1	viability	GAAAGAAGACGCATGCCCAGAGG	MCPH1	ENSG00000147316	0.011179211403503864	[86]	[154]	0	hSpCas9	negative selection	10529037
6445370	6445393	8	+	28162770	SKM1	viability	GAAGAAATGAAAGAAGCGGTTGG	MCPH1	ENSG00000147316	-0.9855004303048849	[27]	[24]	-6	hSpCas9	negative selection	10529038
6445394	6445417	8	+	28162770	SKM1	viability	CTGAAAAGCACACAGAACAAAGG	MCPH1	ENSG00000147316	-0.12266117615571659	[100]	[163]	-1	hSpCas9	negative selection	10529039
6445498	6445521	8	+	28162770	SKM1	viability	GGAGACGTCTACAGAAGAGAAGG	MCPH1	ENSG00000147316	0.08070110062307978	[22]	[42]	0	hSpCas9	negative selection	10529040
6409288	6409311	8	-	28162770	SKM1	viability	GGATGACCACACTTCAACATAGG	MCPH1	ENSG00000147316	-2.9305261548001744	[137]	[31]	-9	hSpCas9	negative selection	10529041
6445514	6445537	8	+	28162770	SKM1	viability	GAGAAGGAAAACTTACCCGGAGG	MCPH1	ENSG00000147316	-0.9740047914670555	[49]	[44]	-6	hSpCas9	negative selection	10698398
6444852	6444875	8	+	28162770	SKM1	viability	CCAGGAGATCTATCATGCCGAGG	MCPH1	ENSG00000147316	-0.7109703856332619	[49]	[53]	-5	hSpCas9	negative selection	10698399
6444895	6444918	8	+	28162770	SKM1	viability	AGACAGGCTGCAGCACGTGGCGG	MCPH1	ENSG00000147316	1.6374299206152916	[9]	[54]	9	hSpCas9	negative selection	10698400
6444923	6444946	8	+	28162770	SKM1	viability	GCCCTGGAGGCTCTTAGCTGTGG	MCPH1	ENSG00000147316	0.41065905876826947	[39]	[93]	4	hSpCas9	negative selection	10698401
6445010	6445033	8	-	28162770	SKM1	viability	GATGGCAGCTGAGATTCAGGAGG	MCPH1	ENSG00000147316	-0.11938760864657641	[50]	[82]	-1	hSpCas9	negative selection	10698402
6445264	6445287	8	+	28162770	SKM1	viability	GAAAGAAGACGCATGCCCAGAGG	MCPH1	ENSG00000147316	0.011179211403503864	[86]	[154]	0	hSpCas9	negative selection	10698403
6445370	6445393	8	+	28162770	SKM1	viability	GAAGAAATGAAAGAAGCGGTTGG	MCPH1	ENSG00000147316	-0.9855004303048849	[27]	[24]	-6	hSpCas9	negative selection	10698404
6445394	6445417	8	+	28162770	SKM1	viability	CTGAAAAGCACACAGAACAAAGG	MCPH1	ENSG00000147316	-0.12266117615571659	[100]	[163]	-1	hSpCas9	negative selection	10698405
6445498	6445521	8	+	28162770	SKM1	viability	GGAGACGTCTACAGAAGAGAAGG	MCPH1	ENSG00000147316	0.08070110062307978	[22]	[42]	0	hSpCas9	negative selection	10698406
6409288	6409311	8	-	28162770	SKM1	viability	GGATGACCACACTTCAACATAGG	MCPH1	ENSG00000147316	-2.9305261548001744	[137]	[31]	-9	hSpCas9	negative selection	10698407
6445514	6445537	8	+	28162770	PL21	viability	GAGAAGGAAAACTTACCCGGAGG	MCPH1	ENSG00000147316	1.2398493242912914	[214]	[220]	8	hSpCas9	negative selection	10867764
6444852	6444875	8	+	28162770	PL21	viability	CCAGGAGATCTATCATGCCGAGG	MCPH1	ENSG00000147316	-1.5336862721463187	[152]	[22]	-7	hSpCas9	negative selection	10867765
6444895	6444918	8	+	28162770	PL21	viability	AGACAGGCTGCAGCACGTGGCGG	MCPH1	ENSG00000147316	0.23490503264999685	[40]	[20]	2	hSpCas9	negative selection	10867766
6444923	6444946	8	+	28162770	PL21	viability	GCCCTGGAGGCTCTTAGCTGTGG	MCPH1	ENSG00000147316	0.7070996032092033	[113]	[80]	6	hSpCas9	negative selection	10867767
6445010	6445033	8	-	28162770	PL21	viability	GATGGCAGCTGAGATTCAGGAGG	MCPH1	ENSG00000147316	0.498363448785414	[134]	[82]	4	hSpCas9	negative selection	10867768
6445264	6445287	8	+	28162770	PL21	viability	GAAAGAAGACGCATGCCCAGAGG	MCPH1	ENSG00000147316	0.09280557037799841	[264]	[122]	0	hSpCas9	negative selection	10867769
6445370	6445393	8	+	28162770	PL21	viability	GAAGAAATGAAAGAAGCGGTTGG	MCPH1	ENSG00000147316	0.14569183046694367	[80]	[38]	1	hSpCas9	negative selection	10867770
6445394	6445417	8	+	28162770	PL21	viability	CTGAAAAGCACACAGAACAAAGG	MCPH1	ENSG00000147316	0.4197059917470046	[291]	[169]	3	hSpCas9	negative selection	10867771
6445498	6445521	8	+	28162770	PL21	viability	GGAGACGTCTACAGAAGAGAAGG	MCPH1	ENSG00000147316	-1.5864567474014866	[68]	[9]	-7	hSpCas9	negative selection	10867772
6409288	6409311	8	-	28162770	PL21	viability	GGATGACCACACTTCAACATAGG	MCPH1	ENSG00000147316	-0.39392509333908854	[476]	[157]	-3	hSpCas9	negative selection	10867773
6445514	6445537	8	+	28162770	P31FUJ	viability	GAGAAGGAAAACTTACCCGGAGG	MCPH1	ENSG00000147316	-0.5873349647336684	[178]	[139]	-5	hSpCas9	negative selection	11037130
6444852	6444875	8	+	28162770	P31FUJ	viability	CCAGGAGATCTATCATGCCGAGG	MCPH1	ENSG00000147316	-0.14194877396326505	[199]	[212]	-1	hSpCas9	negative selection	11037131
6444895	6444918	8	+	28162770	P31FUJ	viability	AGACAGGCTGCAGCACGTGGCGG	MCPH1	ENSG00000147316	0.9247390725721014	[25]	[57]	9	hSpCas9	negative selection	11037132
6444923	6444946	8	+	28162770	P31FUJ	viability	GCCCTGGAGGCTCTTAGCTGTGG	MCPH1	ENSG00000147316	0.48340482958503006	[83]	[137]	5	hSpCas9	negative selection	11037133
6445010	6445033	8	-	28162770	P31FUJ	viability	GATGGCAGCTGAGATTCAGGAGG	MCPH1	ENSG00000147316	0.22478098983054973	[141]	[194]	2	hSpCas9	negative selection	11037134
6445264	6445287	8	+	28162770	P31FUJ	viability	GAAAGAAGACGCATGCCCAGAGG	MCPH1	ENSG00000147316	0.07012492854292807	[213]	[263]	0	hSpCas9	negative selection	11037135
6445370	6445393	8	+	28162770	P31FUJ	viability	GAAGAAATGAAAGAAGCGGTTGG	MCPH1	ENSG00000147316	-0.012203064900981442	[114]	[133]	0	hSpCas9	negative selection	11037136
6445394	6445417	8	+	28162770	P31FUJ	viability	CTGAAAAGCACACAGAACAAAGG	MCPH1	ENSG00000147316	0.17846551210574169	[478]	[636]	1	hSpCas9	negative selection	11037137
6445498	6445521	8	+	28162770	P31FUJ	viability	GGAGACGTCTACAGAAGAGAAGG	MCPH1	ENSG00000147316	-0.3371388642291142	[85]	[79]	-3	hSpCas9	negative selection	11037138
6409288	6409311	8	-	28162770	P31FUJ	viability	GGATGACCACACTTCAACATAGG	MCPH1	ENSG00000147316	-1.132860766540472	[473]	[253]	-7	hSpCas9	negative selection	11037139
6445514	6445537	8	+	28162770	OCIAML5	viability	GAGAAGGAAAACTTACCCGGAGG	MCPH1	ENSG00000147316	0.22593594113727594	[71]	[151]	2	hSpCas9	negative selection	11206496
6444852	6444875	8	+	28162770	OCIAML5	viability	CCAGGAGATCTATCATGCCGAGG	MCPH1	ENSG00000147316	0.1744056404971941	[107]	[219]	1	hSpCas9	negative selection	11206497
6444895	6444918	8	+	28162770	OCIAML5	viability	AGACAGGCTGCAGCACGTGGCGG	MCPH1	ENSG00000147316	0.8678255099432675	[16]	[55]	7	hSpCas9	negative selection	11206498
6444923	6444946	8	+	28162770	OCIAML5	viability	GCCCTGGAGGCTCTTAGCTGTGG	MCPH1	ENSG00000147316	-0.5952911555018854	[76]	[91]	-4	hSpCas9	negative selection	11206499
6445010	6445033	8	-	28162770	OCIAML5	viability	GATGGCAGCTGAGATTCAGGAGG	MCPH1	ENSG00000147316	-0.9015352471282969	[88]	[85]	-5	hSpCas9	negative selection	11206500
6445264	6445287	8	+	28162770	OCIAML5	viability	GAAAGAAGACGCATGCCCAGAGG	MCPH1	ENSG00000147316	0.4777811873196033	[108]	[273]	4	hSpCas9	negative selection	11206501
6445370	6445393	8	+	28162770	OCIAML5	viability	GAAGAAATGAAAGAAGCGGTTGG	MCPH1	ENSG00000147316	0.6426981208855809	[54]	[154]	5	hSpCas9	negative selection	11206502
6445394	6445417	8	+	28162770	OCIAML5	viability	CTGAAAAGCACACAGAACAAAGG	MCPH1	ENSG00000147316	0.5777768631902529	[205]	[554]	5	hSpCas9	negative selection	11206503
6445498	6445521	8	+	28162770	OCIAML5	viability	GGAGACGTCTACAGAAGAGAAGG	MCPH1	ENSG00000147316	-1.1262415343029912	[51]	[42]	-6	hSpCas9	negative selection	11206504
6409288	6409311	8	-	28162770	OCIAML5	viability	GGATGACCACACTTCAACATAGG	MCPH1	ENSG00000147316	-2.3498066594730904	[352]	[124]	-8	hSpCas9	negative selection	11206505
6445514	6445537	8	+	28162770	EOL1	viability	GAGAAGGAAAACTTACCCGGAGG	MCPH1	ENSG00000147316	0.3725625932956512	[345]	[235]	3	hSpCas9	negative selection	11375862
6444852	6444875	8	+	28162770	EOL1	viability	CCAGGAGATCTATCATGCCGAGG	MCPH1	ENSG00000147316	-0.8222656085520186	[244]	[72]	-5	hSpCas9	negative selection	11375863
6444895	6444918	8	+	28162770	EOL1	viability	AGACAGGCTGCAGCACGTGGCGG	MCPH1	ENSG00000147316	1.0458540677926682	[56]	[61]	8	hSpCas9	negative selection	11375864
6444923	6444946	8	+	28162770	EOL1	viability	GCCCTGGAGGCTCTTAGCTGTGG	MCPH1	ENSG00000147316	-1.516024819815447	[227]	[41]	-7	hSpCas9	negative selection	11375865
6445010	6445033	8	-	28162770	EOL1	viability	GATGGCAGCTGAGATTCAGGAGG	MCPH1	ENSG00000147316	-1.634039313726324	[270]	[45]	-7	hSpCas9	negative selection	11375866
6445264	6445287	8	+	28162770	EOL1	viability	GAAAGAAGACGCATGCCCAGAGG	MCPH1	ENSG00000147316	0.09478160209267095	[518]	[291]	0	hSpCas9	negative selection	11375867
6445370	6445393	8	+	28162770	EOL1	viability	GAAGAAATGAAAGAAGCGGTTGG	MCPH1	ENSG00000147316	-1.688429105320218	[103]	[16]	-8	hSpCas9	negative selection	11375868
6445394	6445417	8	+	28162770	EOL1	viability	CTGAAAAGCACACAGAACAAAGG	MCPH1	ENSG00000147316	1.4574795695314755	[366]	[530]	9	hSpCas9	negative selection	11375869
6445498	6445521	8	+	28162770	EOL1	viability	GGAGACGTCTACAGAAGAGAAGG	MCPH1	ENSG00000147316	-0.784403446426075	[84]	[25]	-5	hSpCas9	negative selection	11375870
6409288	6409311	8	-	28162770	EOL1	viability	GGATGACCACACTTCAACATAGG	MCPH1	ENSG00000147316	-2.139068327725437	[509]	[60]	-8	hSpCas9	negative selection	11375871
6445514	6445537	8	+	28162770	MOLM13	viability	GAGAAGGAAAACTTACCCGGAGG	MCPH1	ENSG00000147316	0.8123878880072688	[240]	[305]	6	hSpCas9	negative selection	11545228
6444852	6444875	8	+	28162770	MOLM13	viability	CCAGGAGATCTATCATGCCGAGG	MCPH1	ENSG00000147316	-0.6456731772786211	[250]	[115]	-4	hSpCas9	negative selection	11545229
6444895	6444918	8	+	28162770	MOLM13	viability	AGACAGGCTGCAGCACGTGGCGG	MCPH1	ENSG00000147316	2.478777697687315	[32]	[132]	9	hSpCas9	negative selection	11545230
6444923	6444946	8	+	28162770	MOLM13	viability	GCCCTGGAGGCTCTTAGCTGTGG	MCPH1	ENSG00000147316	1.1630348000161577	[146]	[237]	8	hSpCas9	negative selection	11545231
6445010	6445033	8	-	28162770	MOLM13	viability	GATGGCAGCTGAGATTCAGGAGG	MCPH1	ENSG00000147316	-0.8316709003143291	[255]	[103]	-4	hSpCas9	negative selection	11545232
6445264	6445287	8	+	28162770	MOLM13	viability	GAAAGAAGACGCATGCCCAGAGG	MCPH1	ENSG00000147316	0.17721222064165632	[410]	[335]	1	hSpCas9	negative selection	11545233
6445370	6445393	8	+	28162770	MOLM13	viability	GAAGAAATGAAAGAAGCGGTTGG	MCPH1	ENSG00000147316	-0.39604906887939273	[90]	[49]	-2	hSpCas9	negative selection	11545234
6445394	6445417	8	+	28162770	MOLM13	viability	CTGAAAAGCACACAGAACAAAGG	MCPH1	ENSG00000147316	0.13788242189653155	[581]	[462]	1	hSpCas9	negative selection	11545235
6445498	6445521	8	+	28162770	MOLM13	viability	GGAGACGTCTACAGAAGAGAAGG	MCPH1	ENSG00000147316	-0.4877164990969678	[127]	[65]	-3	hSpCas9	negative selection	11545236
6409288	6409311	8	-	28162770	MOLM13	viability	GGATGACCACACTTCAACATAGG	MCPH1	ENSG00000147316	-4.791977745210532	[727]	[18]	-9	hSpCas9	negative selection	11545237
6445514	6445537	8	+	28162770	HEL	viability	GAGAAGGAAAACTTACCCGGAGG	MCPH1	ENSG00000147316	0.8574776807933695	[242]	[281]	7	hSpCas9	negative selection	11714594
6444852	6444875	8	+	28162770	HEL	viability	CCAGGAGATCTATCATGCCGAGG	MCPH1	ENSG00000147316	0.10094419043557429	[213]	[146]	0	hSpCas9	negative selection	11714595
6444895	6444918	8	+	28162770	HEL	viability	AGACAGGCTGCAGCACGTGGCGG	MCPH1	ENSG00000147316	0.8420476402237638	[26]	[30]	7	hSpCas9	negative selection	11714596
6444923	6444946	8	+	28162770	HEL	viability	GCCCTGGAGGCTCTTAGCTGTGG	MCPH1	ENSG00000147316	0.36263091280762155	[152]	[125]	3	hSpCas9	negative selection	11714597
6445010	6445033	8	-	28162770	HEL	viability	GATGGCAGCTGAGATTCAGGAGG	MCPH1	ENSG00000147316	-0.618928738069531	[210]	[87]	-4	hSpCas9	negative selection	11714598
6445264	6445287	8	+	28162770	HEL	viability	GAAAGAAGACGCATGCCCAGAGG	MCPH1	ENSG00000147316	1.1757735406776524	[263]	[381]	8	hSpCas9	negative selection	11714599
6445370	6445393	8	+	28162770	HEL	viability	GAAGAAATGAAAGAAGCGGTTGG	MCPH1	ENSG00000147316	0.9998954151987008	[88]	[113]	8	hSpCas9	negative selection	11714600
6445394	6445417	8	+	28162770	HEL	viability	CTGAAAAGCACACAGAACAAAGG	MCPH1	ENSG00000147316	0.24900073452196936	[380]	[289]	2	hSpCas9	negative selection	11714601
6445498	6445521	8	+	28162770	HEL	viability	GGAGACGTCTACAGAAGAGAAGG	MCPH1	ENSG00000147316	-0.640195131271142	[72]	[29]	-4	hSpCas9	negative selection	11714602
6409288	6409311	8	-	28162770	HEL	viability	GGATGACCACACTTCAACATAGG	MCPH1	ENSG00000147316	-1.7896752359984607	[528]	[97]	-7	hSpCas9	negative selection	11714603
6445514	6445537	8	+	28162770	MV411	viability	GAGAAGGAAAACTTACCCGGAGG	MCPH1	ENSG00000147316	-1.1248954975418302	[232]	[89]	-6	hSpCas9	negative selection	11883960
6444852	6444875	8	+	28162770	MV411	viability	CCAGGAGATCTATCATGCCGAGG	MCPH1	ENSG00000147316	-1.2067383424030267	[136]	[49]	-7	hSpCas9	negative selection	11883961
6444895	6444918	8	+	28162770	MV411	viability	AGACAGGCTGCAGCACGTGGCGG	MCPH1	ENSG00000147316	1.8774879410324699	[20]	[64]	9	hSpCas9	negative selection	11883962
6444923	6444946	8	+	28162770	MV411	viability	GCCCTGGAGGCTCTTAGCTGTGG	MCPH1	ENSG00000147316	0.5600277810908015	[123]	[153]	5	hSpCas9	negative selection	11883963
6445010	6445033	8	-	28162770	MV411	viability	GATGGCAGCTGAGATTCAGGAGG	MCPH1	ENSG00000147316	-0.4373602175181757	[171]	[106]	-3	hSpCas9	negative selection	11883964
6445264	6445287	8	+	28162770	MV411	viability	GAAAGAAGACGCATGCCCAGAGG	MCPH1	ENSG00000147316	0.38636081718383575	[276]	[304]	3	hSpCas9	negative selection	11883965
6445370	6445393	8	+	28162770	MV411	viability	GAAGAAATGAAAGAAGCGGTTGG	MCPH1	ENSG00000147316	-2.2719366083108046	[85]	[14]	-8	hSpCas9	negative selection	11883966
6445394	6445417	8	+	28162770	MV411	viability	CTGAAAAGCACACAGAACAAAGG	MCPH1	ENSG00000147316	-0.7473258008510776	[274]	[137]	-5	hSpCas9	negative selection	11883967
6445498	6445521	8	+	28162770	MV411	viability	GGAGACGTCTACAGAAGAGAAGG	MCPH1	ENSG00000147316	0.24743755078277552	[61]	[61]	2	hSpCas9	negative selection	11883968
6409288	6409311	8	-	28162770	MV411	viability	GGATGACCACACTTCAACATAGG	MCPH1	ENSG00000147316	-1.6857753580060226	[400]	[104]	-8	hSpCas9	negative selection	11883969
6445514	6445537	8	+	28162770	MONOMAC1	viability	GAGAAGGAAAACTTACCCGGAGG	MCPH1	ENSG00000147316	1.0462343039528101	[97]	[231]	8	hSpCas9	negative selection	12053326
6444852	6444875	8	+	28162770	MONOMAC1	viability	CCAGGAGATCTATCATGCCGAGG	MCPH1	ENSG00000147316	-0.06478904876111419	[124]	[136]	0	hSpCas9	negative selection	12053327
6444895	6444918	8	+	28162770	MONOMAC1	viability	AGACAGGCTGCAGCACGTGGCGG	MCPH1	ENSG00000147316	-0.19703684705955382	[23]	[23]	-2	hSpCas9	negative selection	12053328
6444923	6444946	8	+	28162770	MONOMAC1	viability	GCCCTGGAGGCTCTTAGCTGTGG	MCPH1	ENSG00000147316	0.2623947715777435	[63]	[87]	2	hSpCas9	negative selection	12053329
6445010	6445033	8	-	28162770	MONOMAC1	viability	GATGGCAGCTGAGATTCAGGAGG	MCPH1	ENSG00000147316	-0.46884146252107983	[98]	[81]	-4	hSpCas9	negative selection	12053330
6445264	6445287	8	+	28162770	MONOMAC1	viability	GAAAGAAGACGCATGCCCAGAGG	MCPH1	ENSG00000147316	0.19375310597261286	[179]	[235]	2	hSpCas9	negative selection	12053331
6445370	6445393	8	+	28162770	MONOMAC1	viability	GAAGAAATGAAAGAAGCGGTTGG	MCPH1	ENSG00000147316	0.31075779313914254	[63]	[90]	3	hSpCas9	negative selection	12053332
6445394	6445417	8	+	28162770	MONOMAC1	viability	CTGAAAAGCACACAGAACAAAGG	MCPH1	ENSG00000147316	0.06327805742064796	[176]	[211]	0	hSpCas9	negative selection	12053333
6445498	6445521	8	+	28162770	MONOMAC1	viability	GGAGACGTCTACAGAAGAGAAGG	MCPH1	ENSG00000147316	-0.6665221303607738	[53]	[38]	-5	hSpCas9	negative selection	12053334
6409288	6409311	8	-	28162770	MONOMAC1	viability	GGATGACCACACTTCAACATAGG	MCPH1	ENSG00000147316	-1.2421247365880916	[259]	[125]	-7	hSpCas9	negative selection	12053335
6445514	6445537	8	+	28162770	OCIAML2	viability	GAGAAGGAAAACTTACCCGGAGG	MCPH1	ENSG00000147316	-0.24566346024188682	[39]	[186]	-2	hSpCas9	negative selection	12222692
6444852	6444875	8	+	28162770	OCIAML2	viability	CCAGGAGATCTATCATGCCGAGG	MCPH1	ENSG00000147316	-0.43820834754978377	[32]	[134]	-3	hSpCas9	negative selection	12222693
6444895	6444918	8	+	28162770	OCIAML2	viability	AGACAGGCTGCAGCACGTGGCGG	MCPH1	ENSG00000147316	1.616833016008178	[6]	[118]	9	hSpCas9	negative selection	12222694
6444923	6444946	8	+	28162770	OCIAML2	viability	GCCCTGGAGGCTCTTAGCTGTGG	MCPH1	ENSG00000147316	-1.3186267317971112	[26]	[59]	-7	hSpCas9	negative selection	12222695
6445010	6445033	8	-	28162770	OCIAML2	viability	GATGGCAGCTGAGATTCAGGAGG	MCPH1	ENSG00000147316	-0.148701730354799	[25]	[129]	-1	hSpCas9	negative selection	12222696
6445264	6445287	8	+	28162770	OCIAML2	viability	GAAAGAAGACGCATGCCCAGAGG	MCPH1	ENSG00000147316	0.8335235679172251	[48]	[483]	7	hSpCas9	negative selection	12222697
6445370	6445393	8	+	28162770	OCIAML2	viability	GAAGAAATGAAAGAAGCGGTTGG	MCPH1	ENSG00000147316	-0.2182426636078758	[16]	[80]	-2	hSpCas9	negative selection	12222698
6445394	6445417	8	+	28162770	OCIAML2	viability	CTGAAAAGCACACAGAACAAAGG	MCPH1	ENSG00000147316	0.0014386190730615311	[61]	[343]	0	hSpCas9	negative selection	12222699
6445498	6445521	8	+	28162770	OCIAML2	viability	GGAGACGTCTACAGAAGAGAAGG	MCPH1	ENSG00000147316	1.6903620514301436	[8]	[160]	9	hSpCas9	negative selection	12222700
6409288	6409311	8	-	28162770	OCIAML2	viability	GGATGACCACACTTCAACATAGG	MCPH1	ENSG00000147316	-3.4275611033502753	[98]	[50]	-9	hSpCas9	negative selection	12222701
6445514	6445537	8	+	28162770	OCIAML3	viability	GAGAAGGAAAACTTACCCGGAGG	MCPH1	ENSG00000147316	0.1598317724064391	[50]	[171]	1	hSpCas9	negative selection	12392058
6444852	6444875	8	+	28162770	OCIAML3	viability	CCAGGAGATCTATCATGCCGAGG	MCPH1	ENSG00000147316	-0.5028597522659678	[45]	[97]	-4	hSpCas9	negative selection	12392059
6444895	6444918	8	+	28162770	OCIAML3	viability	AGACAGGCTGCAGCACGTGGCGG	MCPH1	ENSG00000147316	1.4416162694065577	[9]	[81]	9	hSpCas9	negative selection	12392060
6444923	6444946	8	+	28162770	OCIAML3	viability	GCCCTGGAGGCTCTTAGCTGTGG	MCPH1	ENSG00000147316	0.990954860396993	[31]	[191]	8	hSpCas9	negative selection	12392061
6445010	6445033	8	-	28162770	OCIAML3	viability	GATGGCAGCTGAGATTCAGGAGG	MCPH1	ENSG00000147316	-0.05674188163430338	[40]	[118]	0	hSpCas9	negative selection	12392062
6445264	6445287	8	+	28162770	OCIAML3	viability	GAAAGAAGACGCATGCCCAGAGG	MCPH1	ENSG00000147316	0.3543595912605145	[63]	[246]	3	hSpCas9	negative selection	12392063
6445370	6445393	8	+	28162770	OCIAML3	viability	GAAGAAATGAAAGAAGCGGTTGG	MCPH1	ENSG00000147316	-0.03761429179977782	[33]	[99]	0	hSpCas9	negative selection	12392064
6445394	6445417	8	+	28162770	OCIAML3	viability	CTGAAAAGCACACAGAACAAAGG	MCPH1	ENSG00000147316	0.34459181501169367	[83]	[321]	3	hSpCas9	negative selection	12392065
6445498	6445521	8	+	28162770	OCIAML3	viability	GGAGACGTCTACAGAAGAGAAGG	MCPH1	ENSG00000147316	-0.12688162989686513	[16]	[46]	-1	hSpCas9	negative selection	12392066
6409288	6409311	8	-	28162770	OCIAML3	viability	GGATGACCACACTTCAACATAGG	MCPH1	ENSG00000147316	-2.0185054688520734	[101]	[75]	-8	hSpCas9	negative selection	12392067