| 28728819 | 28728842 | 17 | + | 26472758 | Jiyoye | viability | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 0.2841169851015352 | [158] | [145] | 2 | hSpCas9 | negative selection | 107726 | 28728819 | 28728842 | 17 | + | 26472758 | KBM7 | viability | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 0.2779478553736746 | [741,630] | [379,398] | 3 | hSpCas9 | negative selection | 298844 | 28728819 | 28728842 | 17 | + | 26472758 | Raji | viability | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 0.2138204714120734 | [430] | [115] | 2 | hSpCas9 | negative selection | 489962 | 28728819 | 28728842 | 17 | + | 26472758 | K562 | viability | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 0.5727189049664088 | [496] | [623] | 4 | hSpCas9 | negative selection | 681080 | 28728819 | 28728842 | 17 | + | 26627737 | DLD1 | viability | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | -0.015892398876553082 | [335] | [148,70,91] | 0 | hSpCas9 | negative selection | 796731 | 28728819 | 28728842 | 17 | + | 26627737 | GBM cells | viability after 5 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | -0.5907416657397433 | [204] | [61,83] | -7 | hSpCas9 | negative selection | 879046 | 28728819 | 28728842 | 17 | + | 26627737 | GBM cells | viability after 13 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | -0.8440364073297835 | [204] | [56,65] | -7 | hSpCas9 | negative selection | 961361 | 28728819 | 28728842 | 17 | + | 26627737 | GBM cells | viability after 21 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | -1.4069293771110274 | [204] | [41,41] | -8 | hSpCas9 | negative selection | 1043676 | 28728819 | 28728842 | 17 | + | 26627737 | RPE1 | viability after 9 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | -1.1980151598582123 | [577] | [77,79] | -7 | hSpCas9 | negative selection | 1125991 | 28728819 | 28728842 | 17 | + | 26627737 | RPE1 | viability after 12 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | -0.9147421662776009 | [577] | [60,104] | -6 | hSpCas9 | negative selection | 1208306 | 28728819 | 28728842 | 17 | + | 26627737 | RPE1 | viability after 15 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | -1.2307177094170934 | [577] | [31,105] | -6 | hSpCas9 | negative selection | 1290621 | 28728819 | 28728842 | 17 | + | 26627737 | RPE1 | viability after 18 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | -1.1980962634510943 | [577] | [52,83] | -6 | hSpCas9 | negative selection | 1372936 | 28728819 | 28728842 | 17 | + | 26627737 | HeLa | viability after 8 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | -1.4322691725438688 | [523] | [77,88,84] | -9 | hSpCas9 | negative selection | 1455251 | 28728819 | 28728842 | 17 | + | 26627737 | HeLa | viability after 12 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | -0.5999443036271235 | [523] | [259,95,80] | -5 | hSpCas9 | negative selection | 1537566 | 28728819 | 28728842 | 17 | + | 26627737 | HeLa | viability after 15 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | -1.713866764252446 | [523] | [42,115,33] | -9 | hSpCas9 | negative selection | 1619881 | 28728819 | 28728842 | 17 | + | 26627737 | HeLa | viability after 18 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | -1.6328390951892235 | [523] | [28,104,33] | -8 | hSpCas9 | negative selection | 1702196 | 28728819 | 28728842 | 17 | + | 26627737 | HCT116 | viability after 6 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | -0.19302285546909317 | [535] | [74,72] | -1 | hSpCas9 | negative selection | 1784511 | 28728819 | 28728842 | 17 | + | 26627737 | HCT116 | viability after 8 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | -0.5441466854377348 | [277] | [108,81,123] | -6 | hSpCas9 | negative selection | 1866826 | 28728819 | 28728842 | 17 | + | 26627737 | HCT116 | viability after 9 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 0.47519864033752945 | [535] | [227,175] | 3 | hSpCas9 | negative selection | 1949141 | 28728819 | 28728842 | 17 | + | 26627737 | HCT116 | viability after 12 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | -0.5463832131656522 | [277] | [54,55,191] | -5 | hSpCas9 | negative selection | 2031456 | 28728819 | 28728842 | 17 | + | 26627737 | HCT116 | viability after 15 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | -0.4856611302748204 | [277] | [148,139,57] | -5 | hSpCas9 | negative selection | 2113771 | 28728819 | 28728842 | 17 | + | 26627737 | HCT116 | viability after 18 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | -0.9944378989284217 | [277] | [128,53,17] | -7 | hSpCas9 | negative selection | 2196086 | 28728809 | 28728832 | 17 | + | 24336569 | HL60 | viability | ATGAGATGGAGAAGTACGAGCGG | NEK8 | ENSG00000160602 | -0.14683172856509352 | [1139] | [2178] | -1 | hSpCas9 | negative selection | 2279827 | 28728819 | 28728842 | 17 | + | 24336569 | HL60 | viability | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 0.29174806338783976 | [1027] | [2662] | 2 | hSpCas9 | negative selection | 2279828 | 28728809 | 28728832 | 17 | + | 24336569 | KBM7 | viability | ATGAGATGGAGAAGTACGAGCGG | NEK8 | ENSG00000160602 | -0.7437441953711631 | [1109] | [1807] | -5 | hSpCas9 | negative selection | 2347004 | 28728819 | 28728842 | 17 | + | 24336569 | KBM7 | viability | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 0.5139814072302854 | [560] | [2184] | 5 | hSpCas9 | negative selection | 2347005 | 28727057 | 28727080 | 17 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GCTGCTTTCGGGGAGAGTTTAGG | NEK8 | ENSG00000160602 | 0.7572372397469984 | [71,274] | [28,103] | 3 | dCas9-VP64 | positive selection | 2403677 | 28727012 | 28727035 | 17 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GGGAGCCCGCGCCACAGTGAGGG | NEK8 | ENSG00000160602 | 2.4497086484130737 | [129,147] | [230,99] | 7 | dCas9-VP64 | positive selection | 2403678 | 28727080 | 28727103 | 17 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TATAAACTCTGGGCGAAAGGAGG | NEK8 | ENSG00000160602 | 0.7973136514206614 | [13,13] | [8,0] | 3 | dCas9-VP64 | positive selection | 2403679 | 28726333 | 28726356 | 17 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CAGCAGCGCCTGAGGGGCGGGGG | NEK8 | ENSG00000160602 | 0.19746987495871915 | [17,9] | [3,1] | 0 | dCas9-VP64 | positive selection | 2464158 | 28726358 | 28726381 | 17 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GCGCGAGCCGGGTGTCCCCGTGG | NEK8 | ENSG00000160602 | 1.4547348851208106 | [0,3] | [1,0] | 5 | dCas9-VP64 | positive selection | 2464159 | 28726381 | 28726404 | 17 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GGAGCCGGCCGGTGGCCGAGAGG | NEK8 | ENSG00000160602 | 3.299820927257028 | [16,12] | [20,46] | 8 | dCas9-VP64 | positive selection | 2464160 | 28728645 | 28728668 | 17 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CAGCGGGAGGTGTGTGGTGCAGG | NEK8 | ENSG00000160602 | 1.5686454242420833 | [24,1] | [3,12] | 6 | dCas9-VP64 | positive selection | 2472186 | 28728669 | 28728692 | 17 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CCGCCACGCGTCCGTATTTGTGG | NEK8 | ENSG00000160602 | 0.16104525398878367 | [160,228] | [87,3] | 0 | dCas9-VP64 | positive selection | 2472187 | 28728615 | 28728638 | 17 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GGTCGTGAGGGGAAAAGTGACGG | NEK8 | ENSG00000160602 | 2.2353149408055892 | [56,133] | [2,203] | 7 | dCas9-VP64 | positive selection | 2472188 | 28727057 | 28727080 | 17 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GCTGCTTTCGGGGAGAGTTTAGG | NEK8 | ENSG00000160602 | 0.47382714366810486 | [136,223] | [38,120] | 4 | dCas9-VP64 | positive selection | 2498932 | 28727012 | 28727035 | 17 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GGGAGCCCGCGCCACAGTGAGGG | NEK8 | ENSG00000160602 | -0.5905799923865886 | [177,145] | [54,15] | -6 | dCas9-VP64 | positive selection | 2498933 | 28727080 | 28727103 | 17 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TATAAACTCTGGGCGAAAGGAGG | NEK8 | ENSG00000160602 | -0.34290843219005707 | [24,82] | [16,9] | -3 | dCas9-VP64 | positive selection | 2498934 | 28726333 | 28726356 | 17 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CAGCAGCGCCTGAGGGGCGGGGG | NEK8 | ENSG00000160602 | -0.9040417007832868 | [97,148] | [19,21] | -8 | dCas9-VP64 | positive selection | 2559413 | 28726358 | 28726381 | 17 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GCGCGAGCCGGGTGTCCCCGTGG | NEK8 | ENSG00000160602 | 0.6435500065006181 | [29,8] | [18,0] | 5 | dCas9-VP64 | positive selection | 2559414 | 28726381 | 28726404 | 17 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GGAGCCGGCCGGTGGCCGAGAGG | NEK8 | ENSG00000160602 | -0.7718443257043659 | [6,37] | [2,3] | -7 | dCas9-VP64 | positive selection | 2559415 | 28728645 | 28728668 | 17 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CAGCGGGAGGTGTGTGGTGCAGG | NEK8 | ENSG00000160602 | -0.7865390688601586 | [104,81] | [12,21] | -7 | dCas9-VP64 | positive selection | 2567441 | 28728669 | 28728692 | 17 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CCGCCACGCGTCCGTATTTGTGG | NEK8 | ENSG00000160602 | 0.9255918642265015 | [127,125] | [19,133] | 6 | dCas9-VP64 | positive selection | 2567442 | 28728615 | 28728638 | 17 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GGTCGTGAGGGGAAAAGTGACGG | NEK8 | ENSG00000160602 | -0.497039940163371 | [116,47] | [29,8] | -5 | dCas9-VP64 | positive selection | 2567443 | 28726756 | 28726779 | 17 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) | CTGTCCCTCCCGCGCCCGCGAGG | NEK8 | ENSG00000160602 | 0.07603559639823892 | [2] | [1,2] | 2 | hSpCas9 | positive selection | 4176834 | 28726771 | 28726794 | 17 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) | GTTCCCAAGTGCCCACCTCGCGG | NEK8 | ENSG00000160602 | 0.12080153047868279 | [4] | [2,3] | 3 | hSpCas9 | positive selection | 4176835 | 28726756 | 28726779 | 17 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiGuide) | CTGTCCCTCCCGCGCCCGCGAGG | NEK8 | ENSG00000160602 | -0.016734007231629433 | [4] | [4,2,0,0] | 0 | hSpCas9 | positive selection | 4240856 | 28726771 | 28726794 | 17 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiGuide) | GTTCCCAAGTGCCCACCTCGCGG | NEK8 | ENSG00000160602 | -0.10516381704745821 | [3] | [0,3,2,0] | -1 | hSpCas9 | positive selection | 4240857 | 28725923 | 28725946 | 17 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | 0.13460450332717344 | [2] | [1,2] | 2 | hSpCas9 | positive selection | 4367470 | 28726029 | 28726052 | 17 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | -1.1199833272502697 | [2] | [0,0] | -9 | hSpCas9 | positive selection | 4367471 | 28728819 | 28728842 | 17 | + | 27661255 | K562 | viability | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 0.23223568033907405 | [1235,1495] | [1326,1234] | 7 | dCas9-KRAB | negative selection | 5496217 | 28728822 | 28728845 | 17 | + | 27661255 | K562 | viability | GTACGAGCGGATCCGAGTGGTGG | NEK8 | ENSG00000160602 | 0.3045755823173083 | [1014,1295] | [1175,1099] | 8 | dCas9-KRAB | negative selection | 5496218 | 28729011 | 28729034 | 17 | + | 27661255 | K562 | viability | GGGAGACTCCGCCTCTACGGAGG | NEK8 | ENSG00000160602 | 0.06935890954683666 | [922,1239] | [1081,747] | 2 | dCas9-KRAB | negative selection | 5496219 | 28729019 | 28729042 | 17 | - | 27661255 | K562 | viability | GGGCGTGGCCTCCGTAGAGGCGG | NEK8 | ENSG00000160602 | -0.13015761180249313 | [598,651] | [484,430] | -4 | dCas9-KRAB | negative selection | 5496220 | 28725988 | 28726011 | 17 | + | 27661255 | K562 | viability | GCGCGCACGTGCACGGGTAGGGG | NEK8 | ENSG00000160602 | 0.031446750769329346 | [595,602] | [538,446] | 1 | dCas9-KRAB | negative selection | 5517473 | 28726157 | 28726180 | 17 | + | 27661255 | K562 | viability | GATCCCTCTCGGGCCAGTCCAGG | NEK8 | ENSG00000160602 | -0.04201773324222566 | [894,850] | [671,682] | -2 | dCas9-KRAB | negative selection | 5517474 | 28726131 | 28726154 | 17 | - | 27661255 | K562 | viability | GTTCCCAGAACAGACCTAGGAGG | NEK8 | ENSG00000160602 | -0.004763352014353517 | [1001,1402] | [1057,860] | 0 | dCas9-KRAB | negative selection | 5517475 | 28726170 | 28726193 | 17 | - | 27661255 | K562 | viability | GAGAGGCGGCCGGCCTGGACTGG | NEK8 | ENSG00000160602 | 0.15388234288088465 | [549,532] | [521,446] | 5 | dCas9-KRAB | negative selection | 5517476 | 28726226 | 28726249 | 17 | - | 27661255 | K562 | viability | GAGGAGCCAAGGGGCCTAGAGGG | NEK8 | ENSG00000160602 | -0.13803968337258404 | [849,694] | [639,496] | -5 | dCas9-KRAB | negative selection | 5517477 | 28725923 | 28725946 | 17 | - | 27260156 | BXPC3 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | -0.010396671229260246 | [252] | [203,255,290,310] | 0 | hSpCas9 | negative selection | 5639930 | 28726029 | 28726052 | 17 | - | 27260156 | BXPC3 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.1969098424357126 | [366] | [472,346,467,474] | 4 | hSpCas9 | negative selection | 5639931 | 28725923 | 28725946 | 17 | - | 27260156 | A673 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | -0.043353034210567465 | [252] | [320,292,226,343] | -1 | hSpCas9 | negative selection | 5761181 | 28726029 | 28726052 | 17 | - | 27260156 | A673 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.269085440983907 | [366] | [613,469,625,416] | 6 | hSpCas9 | negative selection | 5761182 | 28725923 | 28725946 | 17 | - | 27260156 | A375 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | -1.111090357973839 | [252] | [71,167,214,99] | -8 | hSpCas9 | negative selection | 5882432 | 28726029 | 28726052 | 17 | - | 27260156 | A375 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.1995385923246082 | [366] | [412,543,379,620] | 3 | hSpCas9 | negative selection | 5882433 | 28725923 | 28725946 | 17 | - | 27260156 | COLO741 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | 0.1817416951064481 | [252] | [357,311,423] | 4 | hSpCas9 | negative selection | 6003683 | 28726029 | 28726052 | 17 | - | 27260156 | COLO741 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.10947650074988458 | [366] | [492,551,472] | 2 | hSpCas9 | negative selection | 6003684 | 28725923 | 28725946 | 17 | - | 27260156 | CAL120 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | -0.16302800657628058 | [252] | [282,238,320] | -2 | hSpCas9 | negative selection | 6124934 | 28726029 | 28726052 | 17 | - | 27260156 | CAL120 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.49055789354465973 | [366] | [449,589,851] | 7 | hSpCas9 | negative selection | 6124935 | 28725923 | 28725946 | 17 | - | 27260156 | CADOES1 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | 0.071423782654363 | [252] | [181,264,324,215] | 1 | hSpCas9 | negative selection | 6246185 | 28726029 | 28726052 | 17 | - | 27260156 | CADOES1 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.2288115432218149 | [366] | [385,351,433,428] | 4 | hSpCas9 | negative selection | 6246186 | 28725923 | 28725946 | 17 | - | 27260156 | EWS502 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | 0.25182706402466315 | [252] | [298,227,305,457] | 4 | hSpCas9 | negative selection | 6367436 | 28726029 | 28726052 | 17 | - | 27260156 | EWS502 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.23476011324263193 | [366] | [361,618,408,440] | 4 | hSpCas9 | negative selection | 6367437 | 28725923 | 28725946 | 17 | - | 27260156 | EW8 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | 0.32067525869793223 | [252] | [347,286,226,176] | 6 | hSpCas9 | negative selection | 6488687 | 28726029 | 28726052 | 17 | - | 27260156 | EW8 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.33717417652324033 | [366] | [383,435,358,326] | 6 | hSpCas9 | negative selection | 6488688 | 28725923 | 28725946 | 17 | - | 27260156 | CORL105 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | -0.04020505015082354 | [252] | [228,232,358,340] | 0 | hSpCas9 | negative selection | 6609938 | 28726029 | 28726052 | 17 | - | 27260156 | CORL105 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.4170084747428568 | [366] | [509,616,640,533] | 7 | hSpCas9 | negative selection | 6609939 | 28725923 | 28725946 | 17 | - | 27260156 | HS294T | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | -0.5224514218652234 | [252] | [61,65,70,74] | -6 | hSpCas9 | negative selection | 6731189 | 28726029 | 28726052 | 17 | - | 27260156 | HS294T | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | -0.12469154000429183 | [366] | [117,100,144,163] | -2 | hSpCas9 | negative selection | 6731190 | 28725923 | 28725946 | 17 | - | 27260156 | HCC44 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | -0.15586868135721854 | [252] | [406,168,192,270] | -3 | hSpCas9 | negative selection | 6852440 | 28726029 | 28726052 | 17 | - | 27260156 | HCC44 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | -0.14647740600366793 | [366] | [592,332,345,249] | -2 | hSpCas9 | negative selection | 6852441 | 28725923 | 28725946 | 17 | - | 27260156 | G402 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | -0.5936058281401599 | [252] | [142,98,281,274] | -6 | hSpCas9 | negative selection | 6973691 | 28726029 | 28726052 | 17 | - | 27260156 | G402 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.6238650963592732 | [366] | [1327,585,711,239] | 7 | hSpCas9 | negative selection | 6973692 | 28725923 | 28725946 | 17 | - | 27260156 | L33 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | -0.2446761855689623 | [252] | [245,99,106,192] | -5 | hSpCas9 | negative selection | 7094942 | 28726029 | 28726052 | 17 | - | 27260156 | L33 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | -0.021157798378592496 | [366] | [319,144,242,386] | 0 | hSpCas9 | negative selection | 7094943 | 28725923 | 28725946 | 17 | - | 27260156 | K562 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | 0.5300032184613761 | [252] | [439,270,237,349] | 6 | hSpCas9 | negative selection | 7216193 | 28726029 | 28726052 | 17 | - | 27260156 | K562 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.711021741591148 | [366] | [509,309,879,428] | 8 | hSpCas9 | negative selection | 7216194 | 28725923 | 28725946 | 17 | - | 27260156 | HT29 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | -0.08004511588614582 | [252] | [283,243,372,259] | -2 | hSpCas9 | negative selection | 7337444 | 28726029 | 28726052 | 17 | - | 27260156 | HT29 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.10627405894970238 | [366] | [582,410,369,546] | 2 | hSpCas9 | negative selection | 7337445 | 28725923 | 28725946 | 17 | - | 27260156 | MHHES1 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | 0.3895655263974269 | [252] | [401,395,354,343] | 7 | hSpCas9 | negative selection | 7458695 | 28726029 | 28726052 | 17 | - | 27260156 | MHHES1 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.10002225223097128 | [366] | [420,518,411,419] | 1 | hSpCas9 | negative selection | 7458696 | 28725923 | 28725946 | 17 | - | 27260156 | MEWO | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | 0.12105224206600962 | [252] | [204,263,292] | 2 | hSpCas9 | negative selection | 7579946 | 28726029 | 28726052 | 17 | - | 27260156 | MEWO | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.12562836193094679 | [366] | [493,337,314] | 3 | hSpCas9 | negative selection | 7579947 | 28725923 | 28725946 | 17 | - | 27260156 | LNCAPCLONEFGC | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | -0.138761633960359 | [252] | [183,128,300,237] | -2 | hSpCas9 | negative selection | 7701197 | 28726029 | 28726052 | 17 | - | 27260156 | LNCAPCLONEFGC | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.4564974336349783 | [366] | [378,453,677,347] | 7 | hSpCas9 | negative selection | 7701198 | 28725923 | 28725946 | 17 | - | 27260156 | PANC0327 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | -0.038023402447009635 | [252] | [204,45,404,240] | 0 | hSpCas9 | negative selection | 7822448 | 28726029 | 28726052 | 17 | - | 27260156 | PANC0327 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | -0.20246043326592184 | [366] | [312,233,286,307] | -3 | hSpCas9 | negative selection | 7822449 | 28725923 | 28725946 | 17 | - | 27260156 | NCIH2009 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | -0.031458632495591776 | [252] | [425,280,346] | 0 | hSpCas9 | negative selection | 7943699 | 28726029 | 28726052 | 17 | - | 27260156 | NCIH2009 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.03513173001974912 | [366] | [737,542,335] | 0 | hSpCas9 | negative selection | 7943700 | 28725923 | 28725946 | 17 | - | 27260156 | NCIH1373 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | -0.45432774958839284 | [252] | [440,88,232,27] | -4 | hSpCas9 | negative selection | 8064950 | 28726029 | 28726052 | 17 | - | 27260156 | NCIH1373 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.6609213041130457 | [366] | [609,416,341,339] | 6 | hSpCas9 | negative selection | 8064951 | 28725923 | 28725946 | 17 | - | 27260156 | PATU8902 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | -0.11878364461426649 | [252] | [220,286,267,563] | -1 | hSpCas9 | negative selection | 8186201 | 28726029 | 28726052 | 17 | - | 27260156 | PATU8902 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.7910013952043706 | [366] | [847,973,800,935] | 8 | hSpCas9 | negative selection | 8186202 | 28725923 | 28725946 | 17 | - | 27260156 | PANC1 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | -0.39739515835826444 | [252] | [171,62,139,246] | -6 | hSpCas9 | negative selection | 8307452 | 28726029 | 28726052 | 17 | - | 27260156 | PANC1 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.24686255689708986 | [366] | [203,636,283,414] | 4 | hSpCas9 | negative selection | 8307453 | 28725923 | 28725946 | 17 | - | 27260156 | PANC0813 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | -0.5459742186496992 | [252] | [203,166,254,188] | -7 | hSpCas9 | negative selection | 8428703 | 28726029 | 28726052 | 17 | - | 27260156 | PANC0813 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.024982053543250005 | [366] | [585,395,466,324] | 0 | hSpCas9 | negative selection | 8428704 | 28725923 | 28725946 | 17 | - | 27260156 | RDES | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | -0.04709694003469833 | [252] | [167,280,402,298] | -1 | hSpCas9 | negative selection | 8549954 | 28726029 | 28726052 | 17 | - | 27260156 | RDES | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.40613741920571816 | [366] | [455,571,514,720] | 6 | hSpCas9 | negative selection | 8549955 | 28725923 | 28725946 | 17 | - | 27260156 | PC3 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | 0.09380708210389077 | [252] | [159,291,413,288] | 2 | hSpCas9 | negative selection | 8671205 | 28726029 | 28726052 | 17 | - | 27260156 | PC3 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | -0.004571063651857277 | [366] | [192,345,697,398] | 0 | hSpCas9 | negative selection | 8671206 | 28725923 | 28725946 | 17 | - | 27260156 | PATU8988T | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | -0.18460353011918307 | [252] | [346,265,152,89] | -3 | hSpCas9 | negative selection | 8792456 | 28726029 | 28726052 | 17 | - | 27260156 | PATU8988T | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.17136778439568265 | [366] | [146,448,663,332] | 3 | hSpCas9 | negative selection | 8792457 | 28725923 | 28725946 | 17 | - | 27260156 | T47D | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | -0.06259681746987023 | [252] | [315,282,276,251] | -1 | hSpCas9 | negative selection | 8913707 | 28726029 | 28726052 | 17 | - | 27260156 | T47D | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | -0.0221758357629121 | [366] | [405,402,473,400] | 0 | hSpCas9 | negative selection | 8913708 | 28725923 | 28725946 | 17 | - | 27260156 | SU8686 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | -0.580535461105596 | [252] | [156,141,204,171] | -7 | hSpCas9 | negative selection | 9034958 | 28726029 | 28726052 | 17 | - | 27260156 | SU8686 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.1235110727089761 | [366] | [329,402,455,402] | 2 | hSpCas9 | negative selection | 9034959 | 28725923 | 28725946 | 17 | - | 27260156 | SKES1 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | 0.25255285200736144 | [252] | [427,265,239,281] | 5 | hSpCas9 | negative selection | 9156209 | 28726029 | 28726052 | 17 | - | 27260156 | SKES1 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.08918651469106442 | [366] | [384,408,334,422] | 2 | hSpCas9 | negative selection | 9156210 | 28725923 | 28725946 | 17 | - | 27260156 | TOV112D | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | 0.14720236736023073 | [252] | [276,411,183,280] | 3 | hSpCas9 | negative selection | 9277460 | 28726029 | 28726052 | 17 | - | 27260156 | TOV112D | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.005815787471943112 | [366] | [469,214,348,410] | 0 | hSpCas9 | negative selection | 9277461 | 28725923 | 28725946 | 17 | - | 27260156 | TC71 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | 0.030516922441200856 | [252] | [280,299,277,246] | 0 | hSpCas9 | negative selection | 9398711 | 28726029 | 28726052 | 17 | - | 27260156 | TC71 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.058674597124660666 | [366] | [412,354,341,538] | 1 | hSpCas9 | negative selection | 9398712 | 28725923 | 28725946 | 17 | - | 27260156 | TC32 | viability | CTTCGCTCACTCCATTGTGTCGG | NEK8 | ENSG00000160602 | -0.21478976518554282 | [252] | [328,50,180,289] | -4 | hSpCas9 | negative selection | 9519962 | 28726029 | 28726052 | 17 | - | 27260156 | TC32 | viability | CGCTGACCTTCCGGGCGCTCCGG | NEK8 | ENSG00000160602 | 0.4313369817530889 | [366] | [401,454,558,440] | 7 | hSpCas9 | negative selection | 9519963 | 28728819 | 28728842 | 17 | + | 27869803 | HPAFII | viability after 27 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | -0.08870948240515117 | [250] | [164,89,NaN] | 0 | hSpCas9 | negative selection | 9559749 | 28728819 | 28728842 | 17 | + | 27869803 | HPAFII | viability after 15 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | -0.1748003472265425 | [250] | [328,182,NaN] | -2 | hSpCas9 | negative selection | 9642198 | 28728819 | 28728842 | 17 | + | 27869803 | ASPC1 | viability after 36 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 0.06341913376844256 | [558] | [201,266,152] | 0 | hSpCas9 | negative selection | 9724647 | 28728819 | 28728842 | 17 | + | 27869803 | PATU8988S | viability after 35 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 0.8677674914365436 | [421] | [375,243,NaN] | 8 | hSpCas9 | negative selection | 9807096 | 28728819 | 28728842 | 17 | + | 27869803 | PATU8988S | viability after 31 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 0.7512279619090705 | [421] | [262,308,NaN] | 8 | hSpCas9 | negative selection | 9889545 | 28728819 | 28728842 | 17 | + | 27869803 | HPAFII | viability after 35 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 0.12533667477436683 | [250] | [163,109,NaN] | 0 | hSpCas9 | negative selection | 9971994 | 28728819 | 28728842 | 17 | + | 27869803 | HPAFII | viability after 31 days | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 0.009323334015487017 | [250] | [147,134,NaN] | 0 | hSpCas9 | negative selection | 10054443 | 28728819 | 28728842 | 17 | + | 28162770 | P31FUJ | viability | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 0.18059493648320948 | [219] | [292] | 2 | hSpCas9 | negative selection | 10199346 | 28728819 | 28728842 | 17 | + | 28162770 | TF1 | viability | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | NaN | [NaN] | [146] | 1 | hSpCas9 | negative selection | 10368712 | 28728819 | 28728842 | 17 | + | 28162770 | SKM1 | viability | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 1.1694868021224771 | [84] | [337] | 9 | hSpCas9 | negative selection | 10538078 | 28728819 | 28728842 | 17 | + | 28162770 | SKM1 | viability | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 1.1694868021224771 | [84] | [337] | 9 | hSpCas9 | negative selection | 10707444 | 28728819 | 28728842 | 17 | + | 28162770 | PL21 | viability | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 0.6955505302321838 | [287] | [202] | 6 | hSpCas9 | negative selection | 10876810 | 28728819 | 28728842 | 17 | + | 28162770 | P31FUJ | viability | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 0.18059493648320948 | [219] | [292] | 2 | hSpCas9 | negative selection | 11046176 | 28728819 | 28728842 | 17 | + | 28162770 | OCIAML5 | viability | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | -0.20268734164707036 | [145] | [228] | -1 | hSpCas9 | negative selection | 11215542 | 28728819 | 28728842 | 17 | + | 28162770 | EOL1 | viability | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | -0.8050944817898127 | [523] | [157] | -5 | hSpCas9 | negative selection | 11384908 | 28728819 | 28728842 | 17 | + | 28162770 | MOLM13 | viability | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 1.0042717018206735 | [301] | [437] | 7 | hSpCas9 | negative selection | 11554274 | 28728819 | 28728842 | 17 | + | 28162770 | HEL | viability | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 0.24591919066273826 | [340] | [258] | 2 | hSpCas9 | negative selection | 11723640 | 28728819 | 28728842 | 17 | + | 28162770 | MV411 | viability | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 0.28665886058049406 | [253] | [260] | 2 | hSpCas9 | negative selection | 11893006 | 28728819 | 28728842 | 17 | + | 28162770 | MONOMAC1 | viability | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 0.2631526886116652 | [172] | [237] | 2 | hSpCas9 | negative selection | 12062372 | 28728819 | 28728842 | 17 | + | 28162770 | OCIAML2 | viability | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 0.209855286523286 | [55] | [358] | 2 | hSpCas9 | negative selection | 12231738 | 28728819 | 28728842 | 17 | + | 28162770 | OCIAML3 | viability | GAAGTACGAGCGGATCCGAGTGG | NEK8 | ENSG00000160602 | 0.7319786711375527 | [70] | [355] | 6 | hSpCas9 | negative selection | 12401104 |