Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:4851
• Symbol:NOTCH1
• Description:notch receptor 1

DataSource: http://genomecrispr.dkfz.de/#!/results/NOTCH1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
136506532	136506555	9	+	26472758	Jiyoye	viability	GGCACTTGCAGATGAACCCGCGG	NOTCH1	ENSG00000148400	-0.49971521410264513	[239]	[127]	-4	hSpCas9	negative selection	110203
136510727	136510750	9	-	26472758	Jiyoye	viability	GCATCCTGCCAGAACACCCACGG	NOTCH1	ENSG00000148400	0.8368596567491187	[48]	[65]	6	hSpCas9	negative selection	110204
136505693	136505716	9	-	26472758	Jiyoye	viability	GCAACCCCTGCTACAACCAGGGG	NOTCH1	ENSG00000148400	1.18823355985525	[173]	[298]	7	hSpCas9	negative selection	110205
136544060	136544083	9	-	26472758	Jiyoye	viability	GGTGAGACCTGCCTGAATGGCGG	NOTCH1	ENSG00000148400	0.3161109030994165	[375]	[352]	2	hSpCas9	negative selection	110206
136544031	136544054	9	-	26472758	Jiyoye	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	0.1510770228824561	[165]	[138]	1	hSpCas9	negative selection	110207
136523971	136523994	9	-	26472758	Jiyoye	viability	ACATCTGCCAACAGCTGTGGCGG	NOTCH1	ENSG00000148400	-0.19474025249647997	[213]	[140]	-1	hSpCas9	negative selection	110208
136518761	136518784	9	-	26472758	Jiyoye	viability	CCAAATGCCTGCCAGAACGGCGG	NOTCH1	ENSG00000148400	-1.048504102270316	[95]	[34]	-6	hSpCas9	negative selection	110209
136518740	136518763	9	-	26472758	Jiyoye	viability	GGGACCTGCCACAACACCCACGG	NOTCH1	ENSG00000148400	0.40717538150587274	[0]	[0]	3	hSpCas9	negative selection	110210
136513447	136513470	9	+	26472758	Jiyoye	viability	GCCGCCGTTGACACAAGGGTTGG	NOTCH1	ENSG00000148400	1.285184857127263	[73]	[135]	7	hSpCas9	negative selection	110211
136513076	136513099	9	+	26472758	Jiyoye	viability	GCCCTGGTTCAGACATGGGTTGG	NOTCH1	ENSG00000148400	1.3829278352591963	[29]	[58]	8	hSpCas9	negative selection	110212
136506532	136506555	9	+	26472758	KBM7	viability	GGCACTTGCAGATGAACCCGCGG	NOTCH1	ENSG00000148400	0.7228723652733393	[431,373]	[274,344]	7	hSpCas9	negative selection	301321
136510727	136510750	9	-	26472758	KBM7	viability	GCATCCTGCCAGAACACCCACGG	NOTCH1	ENSG00000148400	0.8834286390335409	[298,256]	[250,230]	8	hSpCas9	negative selection	301322
136505693	136505716	9	-	26472758	KBM7	viability	GCAACCCCTGCTACAACCAGGGG	NOTCH1	ENSG00000148400	0.8286693668421355	[919,832]	[867,609]	8	hSpCas9	negative selection	301323
136544060	136544083	9	-	26472758	KBM7	viability	GGTGAGACCTGCCTGAATGGCGG	NOTCH1	ENSG00000148400	-0.21595733594401478	[1693,1292]	[641,560]	-2	hSpCas9	negative selection	301324
136544031	136544054	9	-	26472758	KBM7	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	0.13832523429941518	[398,296]	[210,148]	1	hSpCas9	negative selection	301325
136523971	136523994	9	-	26472758	KBM7	viability	ACATCTGCCAACAGCTGTGGCGG	NOTCH1	ENSG00000148400	0.6011799448423205	[555,559]	[577,240]	6	hSpCas9	negative selection	301326
136518761	136518784	9	-	26472758	KBM7	viability	CCAAATGCCTGCCAGAACGGCGG	NOTCH1	ENSG00000148400	0.24015262598611808	[272,167]	[165,78]	2	hSpCas9	negative selection	301327
136518740	136518763	9	-	26472758	KBM7	viability	GGGACCTGCCACAACACCCACGG	NOTCH1	ENSG00000148400	0.8959532950901474	[15,5]	[4,12]	8	hSpCas9	negative selection	301328
136513447	136513470	9	+	26472758	KBM7	viability	GCCGCCGTTGACACAAGGGTTGG	NOTCH1	ENSG00000148400	-0.17898730533890267	[543,618]	[238,248]	-2	hSpCas9	negative selection	301329
136513076	136513099	9	+	26472758	KBM7	viability	GCCCTGGTTCAGACATGGGTTGG	NOTCH1	ENSG00000148400	-1.3175814984205836	[286,365]	[21,98]	-7	hSpCas9	negative selection	301330
136506532	136506555	9	+	26472758	Raji	viability	GGCACTTGCAGATGAACCCGCGG	NOTCH1	ENSG00000148400	1.8219813165113512	[155]	[127]	9	hSpCas9	negative selection	492439
136510727	136510750	9	-	26472758	Raji	viability	GCATCCTGCCAGAACACCCACGG	NOTCH1	ENSG00000148400	1.0281568442230244	[130]	[61]	8	hSpCas9	negative selection	492440
136505693	136505716	9	-	26472758	Raji	viability	GCAACCCCTGCTACAACCAGGGG	NOTCH1	ENSG00000148400	1.1696206675015386	[430]	[224]	8	hSpCas9	negative selection	492441
136544060	136544083	9	-	26472758	Raji	viability	GGTGAGACCTGCCTGAATGGCGG	NOTCH1	ENSG00000148400	-0.19190675583403127	[821]	[166]	-2	hSpCas9	negative selection	492442
136544031	136544054	9	-	26472758	Raji	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	0.642715268370155	[206]	[74]	6	hSpCas9	negative selection	492443
136523971	136523994	9	-	26472758	Raji	viability	ACATCTGCCAACAGCTGTGGCGG	NOTCH1	ENSG00000148400	0.323701442300363	[271]	[78]	3	hSpCas9	negative selection	492444
136518761	136518784	9	-	26472758	Raji	viability	CCAAATGCCTGCCAGAACGGCGG	NOTCH1	ENSG00000148400	0.27730853681591194	[127]	[35]	2	hSpCas9	negative selection	492445
136518740	136518763	9	-	26472758	Raji	viability	GGGACCTGCCACAACACCCACGG	NOTCH1	ENSG00000148400	-0.6999713866840054	[6]	[0]	-5	hSpCas9	negative selection	492446
136513447	136513470	9	+	26472758	Raji	viability	GCCGCCGTTGACACAAGGGTTGG	NOTCH1	ENSG00000148400	-0.3544307345746917	[302]	[54]	-3	hSpCas9	negative selection	492447
136513076	136513099	9	+	26472758	Raji	viability	GCCCTGGTTCAGACATGGGTTGG	NOTCH1	ENSG00000148400	-0.08375795197840896	[136]	[29]	0	hSpCas9	negative selection	492448
136506532	136506555	9	+	26472758	K562	viability	GGCACTTGCAGATGAACCCGCGG	NOTCH1	ENSG00000148400	0.44332279608052516	[344]	[395]	3	hSpCas9	negative selection	683557
136510727	136510750	9	-	26472758	K562	viability	GCATCCTGCCAGAACACCCACGG	NOTCH1	ENSG00000148400	-0.47094041031038425	[242]	[147]	-3	hSpCas9	negative selection	683558
136505693	136505716	9	-	26472758	K562	viability	GCAACCCCTGCTACAACCAGGGG	NOTCH1	ENSG00000148400	0.34757926503611525	[741]	[796]	2	hSpCas9	negative selection	683559
136544060	136544083	9	-	26472758	K562	viability	GGTGAGACCTGCCTGAATGGCGG	NOTCH1	ENSG00000148400	-0.7967385970903131	[1279]	[621]	-5	hSpCas9	negative selection	683560
136544031	136544054	9	-	26472758	K562	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	-0.20706076758045733	[293]	[214]	-1	hSpCas9	negative selection	683561
136523971	136523994	9	-	26472758	K562	viability	ACATCTGCCAACAGCTGTGGCGG	NOTCH1	ENSG00000148400	0.8733051847825051	[495]	[766]	7	hSpCas9	negative selection	683562
136518761	136518784	9	-	26472758	K562	viability	CCAAATGCCTGCCAGAACGGCGG	NOTCH1	ENSG00000148400	0.9920315660321615	[242]	[407]	8	hSpCas9	negative selection	683563
136518740	136518763	9	-	26472758	K562	viability	GGGACCTGCCACAACACCCACGG	NOTCH1	ENSG00000148400	-0.17061877161239725	[3]	[2]	-1	hSpCas9	negative selection	683564
136513447	136513470	9	+	26472758	K562	viability	GCCGCCGTTGACACAAGGGTTGG	NOTCH1	ENSG00000148400	1.411038584385087	[436]	[980]	9	hSpCas9	negative selection	683565
136513076	136513099	9	+	26472758	K562	viability	GCCCTGGTTCAGACATGGGTTGG	NOTCH1	ENSG00000148400	-0.9833871898563653	[266]	[113]	-5	hSpCas9	negative selection	683566
136518274	136518297	9	+	26627737	DLD1	viability	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	0.3076030769281064	[1131]	[472,591,279]	3	hSpCas9	negative selection	842115
136518760	136518783	9	-	26627737	DLD1	viability	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	0.8002735204959242	[173]	[86,93,101]	7	hSpCas9	negative selection	842116
136519499	136519522	9	-	26627737	DLD1	viability	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	0.7593518630339748	[300]	[104,248,131]	7	hSpCas9	negative selection	842117
136523017	136523040	9	-	26627737	DLD1	viability	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	-0.2504720809906056	[616]	[198,171,121]	-3	hSpCas9	negative selection	842118
136523901	136523924	9	+	26627737	DLD1	viability	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	-0.29777568294220513	[471]	[137,93,125]	-3	hSpCas9	negative selection	842119
136544039	136544062	9	-	26627737	DLD1	viability	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	-1.386425230416309	[204]	[30,27,15]	-8	hSpCas9	negative selection	842120
136518274	136518297	9	+	26627737	GBM cells	viability after 5 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	-0.1505880865318885	[503]	[205,280]	-2	hSpCas9	negative selection	924430
136518760	136518783	9	-	26627737	GBM cells	viability after 5 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	0.6569410845797214	[67]	[47,66]	8	hSpCas9	negative selection	924431
136519499	136519522	9	-	26627737	GBM cells	viability after 5 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	-0.4625425841883143	[369]	[118,168]	-6	hSpCas9	negative selection	924432
136523017	136523040	9	-	26627737	GBM cells	viability after 5 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	0.027768940562109823	[288]	[176,138]	0	hSpCas9	negative selection	924433
136523901	136523924	9	+	26627737	GBM cells	viability after 5 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	0.17772886341005803	[196]	[126,111]	3	hSpCas9	negative selection	924434
136544039	136544062	9	-	26627737	GBM cells	viability after 5 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	0.2688634846359914	[64]	[39,43]	4	hSpCas9	negative selection	924435
136518274	136518297	9	+	26627737	GBM cells	viability after 13 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	0.02429839235256459	[503]	[351,217]	0	hSpCas9	negative selection	1006745
136518760	136518783	9	-	26627737	GBM cells	viability after 13 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	-0.09039259290687895	[67]	[32,35]	-1	hSpCas9	negative selection	1006746
136519499	136519522	9	-	26627737	GBM cells	viability after 13 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	-1.5493891049877075	[369]	[72,64]	-9	hSpCas9	negative selection	1006747
136523017	136523040	9	-	26627737	GBM cells	viability after 13 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	0.37340144388094804	[288]	[174,225]	5	hSpCas9	negative selection	1006748
136523901	136523924	9	+	26627737	GBM cells	viability after 13 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	0.11005424182611923	[196]	[148,87]	1	hSpCas9	negative selection	1006749
136544039	136544062	9	-	26627737	GBM cells	viability after 13 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	-1.0379029718203292	[64]	[25,9]	-8	hSpCas9	negative selection	1006750
136518274	136518297	9	+	26627737	GBM cells	viability after 21 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	0.10197128907838104	[503]	[296,290]	1	hSpCas9	negative selection	1089060
136518760	136518783	9	-	26627737	GBM cells	viability after 21 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	-1.4369877925941763	[67]	[21,5]	-8	hSpCas9	negative selection	1089061
136519499	136519522	9	-	26627737	GBM cells	viability after 21 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	-2.0887361176045647	[369]	[52,41]	-9	hSpCas9	negative selection	1089062
136523017	136523040	9	-	26627737	GBM cells	viability after 21 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	0.22668994586378216	[288]	[201,166]	2	hSpCas9	negative selection	1089063
136523901	136523924	9	+	26627737	GBM cells	viability after 21 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	-0.04307527369475389	[196]	[94,111]	0	hSpCas9	negative selection	1089064
136544039	136544062	9	-	26627737	GBM cells	viability after 21 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	0.10241432157581953	[64]	[39,35]	1	hSpCas9	negative selection	1089065
136518274	136518297	9	+	26627737	RPE1	viability after 9 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	0.1925842657691127	[1416]	[337,724]	1	hSpCas9	negative selection	1171375
136518760	136518783	9	-	26627737	RPE1	viability after 9 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	6.591115545486685	[1]	[24,105]	9	hSpCas9	negative selection	1171376
136519499	136519522	9	-	26627737	RPE1	viability after 9 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	0.4138202023988162	[850]	[288,439]	3	hSpCas9	negative selection	1171377
136523017	136523040	9	-	26627737	RPE1	viability after 9 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	0.7689981089018529	[648]	[278,432]	5	hSpCas9	negative selection	1171378
136523901	136523924	9	+	26627737	RPE1	viability after 9 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	0.9262708540078614	[692]	[217,662]	6	hSpCas9	negative selection	1171379
136544039	136544062	9	-	26627737	RPE1	viability after 9 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	0.2964598240774148	[384]	[130,169]	2	hSpCas9	negative selection	1171380
136518274	136518297	9	+	26627737	RPE1	viability after 12 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	0.37075569891733895	[1416]	[432,554]	2	hSpCas9	negative selection	1253690
136518760	136518783	9	-	26627737	RPE1	viability after 12 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	7.042952800002409	[1]	[99,39]	9	hSpCas9	negative selection	1253691
136519499	136519522	9	-	26627737	RPE1	viability after 12 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	-0.3704632328561642	[850]	[120,235]	-3	hSpCas9	negative selection	1253692
136523017	136523040	9	-	26627737	RPE1	viability after 12 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	0.7544099362486494	[648]	[349,234]	5	hSpCas9	negative selection	1253693
136523901	136523924	9	+	26627737	RPE1	viability after 12 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	0.41575528186628463	[692]	[192,306]	2	hSpCas9	negative selection	1253694
136544039	136544062	9	-	26627737	RPE1	viability after 12 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	-0.03725139529657184	[384]	[110,89]	0	hSpCas9	negative selection	1253695
136518274	136518297	9	+	26627737	RPE1	viability after 15 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	0.11917398810714563	[1416]	[330,535]	0	hSpCas9	negative selection	1336005
136518760	136518783	9	-	26627737	RPE1	viability after 15 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	7.331049196977364	[1]	[141,41]	9	hSpCas9	negative selection	1336006
136519499	136519522	9	-	26627737	RPE1	viability after 15 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	-0.33308589575724845	[850]	[72,304]	-2	hSpCas9	negative selection	1336007
136523017	136523040	9	-	26627737	RPE1	viability after 15 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	1.2472669936642435	[648]	[473,398]	7	hSpCas9	negative selection	1336008
136523901	136523924	9	+	26627737	RPE1	viability after 15 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	0.7795000263449977	[692]	[223,444]	5	hSpCas9	negative selection	1336009
136544039	136544062	9	-	26627737	RPE1	viability after 15 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	0.6330442960098424	[384]	[258,81]	4	hSpCas9	negative selection	1336010
136518274	136518297	9	+	26627737	RPE1	viability after 18 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	-0.27055204671012556	[1416]	[331,300]	-2	hSpCas9	negative selection	1418320
136518760	136518783	9	-	26627737	RPE1	viability after 18 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	7.866405429355934	[1]	[109,142]	9	hSpCas9	negative selection	1418321
136519499	136519522	9	-	26627737	RPE1	viability after 18 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	-0.3915500044226048	[850]	[147,203]	-2	hSpCas9	negative selection	1418322
136523017	136523040	9	-	26627737	RPE1	viability after 18 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	0.8549832678091001	[648]	[266,369]	5	hSpCas9	negative selection	1418323
136523901	136523924	9	+	26627737	RPE1	viability after 18 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	0.5425546714000603	[692]	[152,399]	3	hSpCas9	negative selection	1418324
136544039	136544062	9	-	26627737	RPE1	viability after 18 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	0.2714343995691606	[384]	[180,65]	1	hSpCas9	negative selection	1418325
136518274	136518297	9	+	26627737	HeLa	viability after 8 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	0.5664475379729406	[662]	[457,455,377]	5	hSpCas9	negative selection	1500635
136518760	136518783	9	-	26627737	HeLa	viability after 8 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	1.7455371725657955	[60]	[29,104,116]	9	hSpCas9	negative selection	1500636
136519499	136519522	9	-	26627737	HeLa	viability after 8 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	-0.7273925541278659	[669]	[100,282,130]	-6	hSpCas9	negative selection	1500637
136523017	136523040	9	-	26627737	HeLa	viability after 8 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	1.4942014852402503	[177]	[233,204,218]	9	hSpCas9	negative selection	1500638
136523901	136523924	9	+	26627737	HeLa	viability after 8 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	0.8122544569140867	[194]	[191,93,168]	6	hSpCas9	negative selection	1500639
136544039	136544062	9	-	26627737	HeLa	viability after 8 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	-1.1631143655403173	[134]	[55,28,1]	-8	hSpCas9	negative selection	1500640
136518274	136518297	9	+	26627737	HeLa	viability after 12 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	-0.18753712141671108	[662]	[180,259,276]	-2	hSpCas9	negative selection	1582950
136518760	136518783	9	-	26627737	HeLa	viability after 12 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	0.8746204907565054	[60]	[9,51,74]	6	hSpCas9	negative selection	1582951
136519499	136519522	9	-	26627737	HeLa	viability after 12 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	-1.488092104831288	[669]	[102,100,91]	-8	hSpCas9	negative selection	1582952
136523017	136523040	9	-	26627737	HeLa	viability after 12 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	1.659707846046801	[177]	[345,114,251]	9	hSpCas9	negative selection	1582953
136523901	136523924	9	+	26627737	HeLa	viability after 12 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	0.21752362597257213	[194]	[72,88,118]	2	hSpCas9	negative selection	1582954
136544039	136544062	9	-	26627737	HeLa	viability after 12 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	-0.6754067006403326	[134]	[18,56,25]	-6	hSpCas9	negative selection	1582955
136518274	136518297	9	+	26627737	HeLa	viability after 15 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	1.215844260663442	[662]	[1114,331,410]	8	hSpCas9	negative selection	1665265
136518760	136518783	9	-	26627737	HeLa	viability after 15 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	1.0730607841605897	[60]	[36,78,39]	7	hSpCas9	negative selection	1665266
136519499	136519522	9	-	26627737	HeLa	viability after 15 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	-1.4559698080745453	[669]	[7,124,171]	-8	hSpCas9	negative selection	1665267
136523017	136523040	9	-	26627737	HeLa	viability after 15 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	1.5811689756967882	[177]	[109,141,414]	9	hSpCas9	negative selection	1665268
136523901	136523924	9	+	26627737	HeLa	viability after 15 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	0.9452336350125485	[194]	[215,97,142]	7	hSpCas9	negative selection	1665269
136544039	136544062	9	-	26627737	HeLa	viability after 15 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	0.26721305573403353	[134]	[80,65,49]	2	hSpCas9	negative selection	1665270
136518274	136518297	9	+	26627737	HeLa	viability after 18 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	1.2455236950844355	[662]	[770,277,410]	8	hSpCas9	negative selection	1747580
136518760	136518783	9	-	26627737	HeLa	viability after 18 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	1.0507864665193036	[60]	[21,66,39]	7	hSpCas9	negative selection	1747581
136519499	136519522	9	-	26627737	HeLa	viability after 18 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	-1.4782997407613527	[669]	[5,98,171]	-8	hSpCas9	negative selection	1747582
136523017	136523040	9	-	26627737	HeLa	viability after 18 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	1.5720061319798528	[177]	[69,118,414]	8	hSpCas9	negative selection	1747583
136523901	136523924	9	+	26627737	HeLa	viability after 18 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	0.9430668168926043	[194]	[142,82,142]	7	hSpCas9	negative selection	1747584
136544039	136544062	9	-	26627737	HeLa	viability after 18 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	0.21854023436964942	[134]	[52,50,49]	1	hSpCas9	negative selection	1747585
136518274	136518297	9	+	26627737	HCT116	viability after 6 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	-0.6101547380503387	[1211]	[245,57]	-3	hSpCas9	negative selection	1829895
136518760	136518783	9	-	26627737	HCT116	viability after 6 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	1.1058712089431175	[312]	[5,160]	6	hSpCas9	negative selection	1829896
136519499	136519522	9	-	26627737	HCT116	viability after 6 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	1.7893779048424325	[490]	[37,392]	8	hSpCas9	negative selection	1829897
136523017	136523040	9	-	26627737	HCT116	viability after 6 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	1.2098593268111972	[556]	[101,257]	6	hSpCas9	negative selection	1829898
136523901	136523924	9	+	26627737	HCT116	viability after 6 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	-0.046532168231255194	[635]	[168,56]	0	hSpCas9	negative selection	1829899
136544039	136544062	9	-	26627737	HCT116	viability after 6 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	4.946690181310434	[22]	[271,22]	9	hSpCas9	negative selection	1829900
136518274	136518297	9	+	26627737	HCT116	viability after 8 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	-0.06598699625891724	[852]	[532,404,410]	0	hSpCas9	negative selection	1912210
136518760	136518783	9	-	26627737	HCT116	viability after 8 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	0.9775841233666513	[103]	[34,176,124]	8	hSpCas9	negative selection	1912211
136519499	136519522	9	-	26627737	HCT116	viability after 8 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	0.238666867146808	[247]	[122,195,163]	2	hSpCas9	negative selection	1912212
136523017	136523040	9	-	26627737	HCT116	viability after 8 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	0.5559570896170924	[259]	[276,140,214]	5	hSpCas9	negative selection	1912213
136523901	136523924	9	+	26627737	HCT116	viability after 8 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	0.37560398339576806	[237]	[196,150,162]	4	hSpCas9	negative selection	1912214
136544039	136544062	9	-	26627737	HCT116	viability after 8 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	-1.9222863959327126	[335]	[34,37,72]	-9	hSpCas9	negative selection	1912215
136518274	136518297	9	+	26627737	HCT116	viability after 9 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	0.38457721421995306	[1211]	[331,493]	3	hSpCas9	negative selection	1994525
136518760	136518783	9	-	26627737	HCT116	viability after 9 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	1.794162786362648	[312]	[481,137]	9	hSpCas9	negative selection	1994526
136519499	136519522	9	-	26627737	HCT116	viability after 9 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	0.41156248741186163	[490]	[308,67]	3	hSpCas9	negative selection	1994527
136523017	136523040	9	-	26627737	HCT116	viability after 9 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	0.7792361747592884	[556]	[352,177]	5	hSpCas9	negative selection	1994528
136523901	136523924	9	+	26627737	HCT116	viability after 9 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	0.10951024589089176	[635]	[266,116]	0	hSpCas9	negative selection	1994529
136544039	136544062	9	-	26627737	HCT116	viability after 9 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	2.817632922076216	[22]	[49,37]	9	hSpCas9	negative selection	1994530
136518274	136518297	9	+	26627737	HCT116	viability after 12 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	-0.20724886324040925	[852]	[503,317,330]	-2	hSpCas9	negative selection	2076840
136518760	136518783	9	-	26627737	HCT116	viability after 12 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	1.2266078275763406	[103]	[68,132,186]	8	hSpCas9	negative selection	2076841
136519499	136519522	9	-	26627737	HCT116	viability after 12 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	0.41047514513779804	[247]	[184,187,145]	4	hSpCas9	negative selection	2076842
136523017	136523040	9	-	26627737	HCT116	viability after 12 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	0.47795346540613826	[259]	[222,229,115]	4	hSpCas9	negative selection	2076843
136523901	136523924	9	+	26627737	HCT116	viability after 12 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	0.5704407574855317	[237]	[186,181,187]	5	hSpCas9	negative selection	2076844
136544039	136544062	9	-	26627737	HCT116	viability after 12 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	-1.0879927670271052	[335]	[69,68,110]	-8	hSpCas9	negative selection	2076845
136518274	136518297	9	+	26627737	HCT116	viability after 15 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	0.20859318576382613	[852]	[877,441,417]	2	hSpCas9	negative selection	2159155
136518760	136518783	9	-	26627737	HCT116	viability after 15 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	0.6638077585613795	[103]	[71,104,103]	6	hSpCas9	negative selection	2159156
136519499	136519522	9	-	26627737	HCT116	viability after 15 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	1.011788270192362	[247]	[351,275,241]	8	hSpCas9	negative selection	2159157
136523017	136523040	9	-	26627737	HCT116	viability after 15 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	1.007765183773118	[259]	[349,190,364]	8	hSpCas9	negative selection	2159158
136523901	136523924	9	+	26627737	HCT116	viability after 15 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	0.40085191583149293	[237]	[177,175,186]	4	hSpCas9	negative selection	2159159
136544039	136544062	9	-	26627737	HCT116	viability after 15 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	-0.8259641940813598	[335]	[145,69,114]	-7	hSpCas9	negative selection	2159160
136518274	136518297	9	+	26627737	HCT116	viability after 18 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	0.4875811081957391	[852]	[960,391,384]	4	hSpCas9	negative selection	2241470
136518760	136518783	9	-	26627737	HCT116	viability after 18 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	0.6116022779747505	[103]	[0,111,116]	5	hSpCas9	negative selection	2241471
136519499	136519522	9	-	26627737	HCT116	viability after 18 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	1.2546137618756326	[247]	[310,371,163]	8	hSpCas9	negative selection	2241472
136523017	136523040	9	-	26627737	HCT116	viability after 18 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	0.6810077143067738	[259]	[209,65,343]	5	hSpCas9	negative selection	2241473
136523901	136523924	9	+	26627737	HCT116	viability after 18 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	0.47265286301196496	[237]	[209,138,129]	4	hSpCas9	negative selection	2241474
136544039	136544062	9	-	26627737	HCT116	viability after 18 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	-0.8750496017175576	[335]	[77,38,154]	-7	hSpCas9	negative selection	2241475
136544039	136544062	9	-	24336569	HL60	viability	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	0.05704025218711356	[654]	[1441]	0	hSpCas9	negative selection	2280815
136544046	136544069	9	-	24336569	HL60	viability	GAATGGCGGGAAGTGTGAAGCGG	NOTCH1	ENSG00000148400	0.3495356934059356	[572]	[1544]	3	hSpCas9	negative selection	2280816
136544053	136544076	9	+	24336569	HL60	viability	ACACTTCCCGCCATTCAGGCAGG	NOTCH1	ENSG00000148400	3.306266052654212	[44]	[941]	9	hSpCas9	negative selection	2280817
136544059	136544082	9	-	24336569	HL60	viability	GTGAGACCTGCCTGAATGGCGGG	NOTCH1	ENSG00000148400	1.5605824480567656	[350]	[2190]	9	hSpCas9	negative selection	2280818
136544067	136544090	9	+	24336569	HL60	viability	TCAGGCAGGTCTCACCGGGCTGG	NOTCH1	ENSG00000148400	0.16364839720763502	[161]	[383]	1	hSpCas9	negative selection	2280819
136544078	136544101	9	+	24336569	HL60	viability	TCACCGGGCTGGGAGCATCGCGG	NOTCH1	ENSG00000148400	1.1236237105493505	[652]	[3010]	8	hSpCas9	negative selection	2280820
136545712	136545735	9	+	24336569	HL60	viability	GGGTGGGCGCCTACCTCGTGCGG	NOTCH1	ENSG00000148400	-1.8576891252423295	[595]	[347]	-9	hSpCas9	negative selection	2280821
136545721	136545744	9	+	24336569	HL60	viability	CCTACCTCGTGCGGCGAGCGCGG	NOTCH1	ENSG00000148400	0.2451864045008693	[365]	[917]	2	hSpCas9	negative selection	2280822
136545744	136545767	9	+	24336569	HL60	viability	GCAGCAGCGCCAGGCAGAGCAGG	NOTCH1	ENSG00000148400	-1.0007243970527229	[1163]	[1230]	-7	hSpCas9	negative selection	2280823
136545771	136545794	9	-	24336569	HL60	viability	GGGAGGCATGCCGCCGCTCCTGG	NOTCH1	ENSG00000148400	0.2309799732960115	[640]	[1591]	2	hSpCas9	negative selection	2280824
136544039	136544062	9	-	24336569	KBM7	viability	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	-0.7298178132798281	[483]	[795]	-5	hSpCas9	negative selection	2347992
136544046	136544069	9	-	24336569	KBM7	viability	GAATGGCGGGAAGTGTGAAGCGG	NOTCH1	ENSG00000148400	0.10041697781832604	[671]	[1964]	0	hSpCas9	negative selection	2347993
136544053	136544076	9	+	24336569	KBM7	viability	ACACTTCCCGCCATTCAGGCAGG	NOTCH1	ENSG00000148400	3.961226349018447	[28]	[1231]	9	hSpCas9	negative selection	2347994
136544059	136544082	9	-	24336569	KBM7	viability	GTGAGACCTGCCTGAATGGCGGG	NOTCH1	ENSG00000148400	0.31418648331938653	[495]	[1681]	3	hSpCas9	negative selection	2347995
136544067	136544090	9	+	24336569	KBM7	viability	TCAGGCAGGTCTCACCGGGCTGG	NOTCH1	ENSG00000148400	-1.168863168482819	[182]	[221]	-7	hSpCas9	negative selection	2347996
136544078	136544101	9	+	24336569	KBM7	viability	TCACCGGGCTGGGAGCATCGCGG	NOTCH1	ENSG00000148400	0.46596744334994933	[691]	[2606]	4	hSpCas9	negative selection	2347997
136545712	136545735	9	+	24336569	KBM7	viability	GGGTGGGCGCCTACCTCGTGCGG	NOTCH1	ENSG00000148400	0.19690185212865413	[276]	[865]	1	hSpCas9	negative selection	2347998
136545721	136545744	9	+	24336569	KBM7	viability	CCTACCTCGTGCGGCGAGCGCGG	NOTCH1	ENSG00000148400	1.2232737256038595	[431]	[2750]	8	hSpCas9	negative selection	2347999
136545744	136545767	9	+	24336569	KBM7	viability	GCAGCAGCGCCAGGCAGAGCAGG	NOTCH1	ENSG00000148400	0.044273899780792325	[655]	[1844]	0	hSpCas9	negative selection	2348000
136545771	136545794	9	-	24336569	KBM7	viability	GGGAGGCATGCCGCCGCTCCTGG	NOTCH1	ENSG00000148400	-1.0289213815913416	[596]	[797]	-6	hSpCas9	negative selection	2348001
136526235	136526258	9	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGCTGGGCTGGGCTGGGCTGTGG	NOTCH1	ENSG00000148400	0.3786358653925427	[42,27]	[8,9]	1	dCas9-VP64	positive selection	2470191
136526235	136526258	9	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGCTGGGCTGGGCTGGGCTGTGG	NOTCH1	ENSG00000148400	1.3672143473725054	[82,141]	[88,99]	7	dCas9-VP64	positive selection	2565446
136545744	136545767	9	+	27260157	DLD1	viability	GCAGCAGCGCCAGGCAGAGCAGG	NOTCH1	ENSG00000148400	0.358035849025349	[]	[]	4	hSpCas9	negative selection	2573952
136545721	136545744	9	+	27260157	DLD1	viability	CCTACCTCGTGCGGCGAGCGCGG	NOTCH1	ENSG00000148400	-0.0594824205702254	[]	[]	0	hSpCas9	negative selection	2577078
136544053	136544076	9	+	27260157	DLD1	viability	ACACTTCCCGCCATTCAGGCAGG	NOTCH1	ENSG00000148400	0.837293628387134	[]	[]	9	hSpCas9	negative selection	2579374
136545712	136545735	9	+	27260157	DLD1	viability	GGGTGGGCGCCTACCTCGTGCGG	NOTCH1	ENSG00000148400	-0.817259166505186	[]	[]	-6	hSpCas9	negative selection	2586280
136544078	136544101	9	+	27260157	DLD1	viability	TCACCGGGCTGGGAGCATCGCGG	NOTCH1	ENSG00000148400	0.0628101512184717	[]	[]	3	hSpCas9	negative selection	2605058
136544031	136544054	9	-	27260157	DLD1	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	-0.283533941021552	[]	[]	-2	hSpCas9	negative selection	2605484
136523946	136523969	9	+	27260157	DLD1	viability	CTGGCATCGCGGGCCCACGAAGG	NOTCH1	ENSG00000148400	0.0884696702697806	[]	[]	3	hSpCas9	negative selection	2609846
136523969	136523992	9	-	27260157	DLD1	viability	ATCTGCCAACAGCTGTGGCGGGG	NOTCH1	ENSG00000148400	0.418815832401449	[]	[]	7	hSpCas9	negative selection	2609997
136544023	136544046	9	+	27260157	DLD1	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	-0.00663836225089971	[]	[]	0	hSpCas9	negative selection	2617191
136523898	136523921	9	+	27260157	DLD1	viability	GCATGTCCCGGCGTTCTTGCAGG	NOTCH1	ENSG00000148400	-0.161787226788308	[]	[]	-1	hSpCas9	negative selection	2621539
136523888	136523911	9	-	27260157	DLD1	viability	CGCCGGGACATGCCACGTGGTGG	NOTCH1	ENSG00000148400	-1.86159741318935	[]	[]	-8	hSpCas9	negative selection	2621645
136544039	136544062	9	-	27260157	DLD1	viability	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	0.229746216881929	[]	[]	3	hSpCas9	negative selection	2623554
136523886	136523909	9	+	27260157	DLD1	viability	GTCCACCACGTGGCATGTCCCGG	NOTCH1	ENSG00000148400	0.682151135841998	[]	[]	8	hSpCas9	negative selection	2641223
136523945	136523968	9	-	27260157	DLD1	viability	CTTCGTGGGCCCGCGATGCCAGG	NOTCH1	ENSG00000148400	1.32142297936397	[]	[]	9	hSpCas9	negative selection	2642538
136545771	136545794	9	-	27260157	DLD1	viability	GGGAGGCATGCCGCCGCTCCTGG	NOTCH1	ENSG00000148400	-0.239824996873235	[]	[]	-2	hSpCas9	negative selection	2645821
136544067	136544090	9	+	27260157	DLD1	viability	TCAGGCAGGTCTCACCGGGCTGG	NOTCH1	ENSG00000148400	-0.270878960649528	[]	[]	-2	hSpCas9	negative selection	2649630
136545744	136545767	9	+	27260157	HT1080	viability	GCAGCAGCGCCAGGCAGAGCAGG	NOTCH1	ENSG00000148400	0.0159935311968197	[]	[]	0	hSpCas9	negative selection	2650082
136545721	136545744	9	+	27260157	HT1080	viability	CCTACCTCGTGCGGCGAGCGCGG	NOTCH1	ENSG00000148400	0.597081746428047	[]	[]	5	hSpCas9	negative selection	2653208
136544053	136544076	9	+	27260157	HT1080	viability	ACACTTCCCGCCATTCAGGCAGG	NOTCH1	ENSG00000148400	0.447558105952596	[]	[]	4	hSpCas9	negative selection	2655504
136545712	136545735	9	+	27260157	HT1080	viability	GGGTGGGCGCCTACCTCGTGCGG	NOTCH1	ENSG00000148400	-1.29186844811666	[]	[]	-9	hSpCas9	negative selection	2662410
136544078	136544101	9	+	27260157	HT1080	viability	TCACCGGGCTGGGAGCATCGCGG	NOTCH1	ENSG00000148400	-0.777236876187076	[]	[]	-8	hSpCas9	negative selection	2681188
136544031	136544054	9	-	27260157	HT1080	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	-1.25726435757476	[]	[]	-9	hSpCas9	negative selection	2681614
136523946	136523969	9	+	27260157	HT1080	viability	CTGGCATCGCGGGCCCACGAAGG	NOTCH1	ENSG00000148400	-0.743319544940769	[]	[]	-8	hSpCas9	negative selection	2685976
136523969	136523992	9	-	27260157	HT1080	viability	ATCTGCCAACAGCTGTGGCGGGG	NOTCH1	ENSG00000148400	0.0668372284752778	[]	[]	0	hSpCas9	negative selection	2686127
136544023	136544046	9	+	27260157	HT1080	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.227130080022024	[]	[]	2	hSpCas9	negative selection	2693321
136523898	136523921	9	+	27260157	HT1080	viability	GCATGTCCCGGCGTTCTTGCAGG	NOTCH1	ENSG00000148400	-1.66553675720392	[]	[]	-9	hSpCas9	negative selection	2697669
136523888	136523911	9	-	27260157	HT1080	viability	CGCCGGGACATGCCACGTGGTGG	NOTCH1	ENSG00000148400	-0.739528993385357	[]	[]	-8	hSpCas9	negative selection	2697775
136544039	136544062	9	-	27260157	HT1080	viability	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	0.200124724723011	[]	[]	2	hSpCas9	negative selection	2699684
136523886	136523909	9	+	27260157	HT1080	viability	GTCCACCACGTGGCATGTCCCGG	NOTCH1	ENSG00000148400	-1.04199158553668	[]	[]	-8	hSpCas9	negative selection	2717353
136523945	136523968	9	-	27260157	HT1080	viability	CTTCGTGGGCCCGCGATGCCAGG	NOTCH1	ENSG00000148400	1.29176645487429	[]	[]	9	hSpCas9	negative selection	2718668
136545771	136545794	9	-	27260157	HT1080	viability	GGGAGGCATGCCGCCGCTCCTGG	NOTCH1	ENSG00000148400	0.635442636424018	[]	[]	5	hSpCas9	negative selection	2721951
136544067	136544090	9	+	27260157	HT1080	viability	TCAGGCAGGTCTCACCGGGCTGG	NOTCH1	ENSG00000148400	0.0684347391108451	[]	[]	0	hSpCas9	negative selection	2725760
136545744	136545767	9	+	27260157	MKN45	viability	GCAGCAGCGCCAGGCAGAGCAGG	NOTCH1	ENSG00000148400	1.20126534029716	[]	[]	9	hSpCas9	negative selection	2726212
136545721	136545744	9	+	27260157	MKN45	viability	CCTACCTCGTGCGGCGAGCGCGG	NOTCH1	ENSG00000148400	-0.287875159022318	[]	[]	-1	hSpCas9	negative selection	2729338
136544053	136544076	9	+	27260157	MKN45	viability	ACACTTCCCGCCATTCAGGCAGG	NOTCH1	ENSG00000148400	0.600891103285206	[]	[]	7	hSpCas9	negative selection	2731634
136545712	136545735	9	+	27260157	MKN45	viability	GGGTGGGCGCCTACCTCGTGCGG	NOTCH1	ENSG00000148400	-0.796460672427723	[]	[]	-7	hSpCas9	negative selection	2738540
136544078	136544101	9	+	27260157	MKN45	viability	TCACCGGGCTGGGAGCATCGCGG	NOTCH1	ENSG00000148400	0.310540325742099	[]	[]	5	hSpCas9	negative selection	2757318
136544031	136544054	9	-	27260157	MKN45	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	0.0672258508126172	[]	[]	0	hSpCas9	negative selection	2757744
136523946	136523969	9	+	27260157	MKN45	viability	CTGGCATCGCGGGCCCACGAAGG	NOTCH1	ENSG00000148400	0.394818430428655	[]	[]	6	hSpCas9	negative selection	2762106
136523969	136523992	9	-	27260157	MKN45	viability	ATCTGCCAACAGCTGTGGCGGGG	NOTCH1	ENSG00000148400	-0.256586025280477	[]	[]	-1	hSpCas9	negative selection	2762257
136544023	136544046	9	+	27260157	MKN45	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.352383859831582	[]	[]	6	hSpCas9	negative selection	2769451
136523898	136523921	9	+	27260157	MKN45	viability	GCATGTCCCGGCGTTCTTGCAGG	NOTCH1	ENSG00000148400	-0.843128080544978	[]	[]	-7	hSpCas9	negative selection	2773799
136523888	136523911	9	-	27260157	MKN45	viability	CGCCGGGACATGCCACGTGGTGG	NOTCH1	ENSG00000148400	-0.474586539795727	[]	[]	-6	hSpCas9	negative selection	2773905
136544039	136544062	9	-	27260157	MKN45	viability	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	0.494275100291502	[]	[]	6	hSpCas9	negative selection	2775814
136523886	136523909	9	+	27260157	MKN45	viability	GTCCACCACGTGGCATGTCCCGG	NOTCH1	ENSG00000148400	-0.0980182521933616	[]	[]	0	hSpCas9	negative selection	2793483
136523945	136523968	9	-	27260157	MKN45	viability	CTTCGTGGGCCCGCGATGCCAGG	NOTCH1	ENSG00000148400	1.22296778984103	[]	[]	9	hSpCas9	negative selection	2794798
136545771	136545794	9	-	27260157	MKN45	viability	GGGAGGCATGCCGCCGCTCCTGG	NOTCH1	ENSG00000148400	-0.0666172488567966	[]	[]	0	hSpCas9	negative selection	2798081
136544067	136544090	9	+	27260157	MKN45	viability	TCAGGCAGGTCTCACCGGGCTGG	NOTCH1	ENSG00000148400	-0.700229007700339	[]	[]	-7	hSpCas9	negative selection	2801890
136545744	136545767	9	+	27260157	RKO	viability	GCAGCAGCGCCAGGCAGAGCAGG	NOTCH1	ENSG00000148400	-0.468805063118393	[]	[]	-6	hSpCas9	negative selection	2802342
136545721	136545744	9	+	27260157	RKO	viability	CCTACCTCGTGCGGCGAGCGCGG	NOTCH1	ENSG00000148400	-0.0625487261601549	[]	[]	0	hSpCas9	negative selection	2805468
136544053	136544076	9	+	27260157	RKO	viability	ACACTTCCCGCCATTCAGGCAGG	NOTCH1	ENSG00000148400	0.529187239942435	[]	[]	3	hSpCas9	negative selection	2807764
136545712	136545735	9	+	27260157	RKO	viability	GGGTGGGCGCCTACCTCGTGCGG	NOTCH1	ENSG00000148400	0.0699475147684412	[]	[]	0	hSpCas9	negative selection	2814670
136544078	136544101	9	+	27260157	RKO	viability	TCACCGGGCTGGGAGCATCGCGG	NOTCH1	ENSG00000148400	0.319972496595999	[]	[]	1	hSpCas9	negative selection	2833448
136544031	136544054	9	-	27260157	RKO	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	-0.432976023506009	[]	[]	-6	hSpCas9	negative selection	2833874
136523946	136523969	9	+	27260157	RKO	viability	CTGGCATCGCGGGCCCACGAAGG	NOTCH1	ENSG00000148400	-0.535632247909495	[]	[]	-6	hSpCas9	negative selection	2838236
136523969	136523992	9	-	27260157	RKO	viability	ATCTGCCAACAGCTGTGGCGGGG	NOTCH1	ENSG00000148400	0.440191322941159	[]	[]	2	hSpCas9	negative selection	2838387
136544023	136544046	9	+	27260157	RKO	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.287540949268721	[]	[]	1	hSpCas9	negative selection	2845581
136523898	136523921	9	+	27260157	RKO	viability	GCATGTCCCGGCGTTCTTGCAGG	NOTCH1	ENSG00000148400	-0.523324272711779	[]	[]	-6	hSpCas9	negative selection	2849929
136523888	136523911	9	-	27260157	RKO	viability	CGCCGGGACATGCCACGTGGTGG	NOTCH1	ENSG00000148400	-1.23612848504021	[]	[]	-8	hSpCas9	negative selection	2850035
136544039	136544062	9	-	27260157	RKO	viability	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	-0.594877838240406	[]	[]	-7	hSpCas9	negative selection	2851944
136523886	136523909	9	+	27260157	RKO	viability	GTCCACCACGTGGCATGTCCCGG	NOTCH1	ENSG00000148400	0.126665636879975	[]	[]	0	hSpCas9	negative selection	2869613
136523945	136523968	9	-	27260157	RKO	viability	CTTCGTGGGCCCGCGATGCCAGG	NOTCH1	ENSG00000148400	1.8458456583317	[]	[]	9	hSpCas9	negative selection	2870928
136545771	136545794	9	-	27260157	RKO	viability	GGGAGGCATGCCGCCGCTCCTGG	NOTCH1	ENSG00000148400	-0.101257550547322	[]	[]	0	hSpCas9	negative selection	2874211
136544067	136544090	9	+	27260157	RKO	viability	TCAGGCAGGTCTCACCGGGCTGG	NOTCH1	ENSG00000148400	-0.704251695258863	[]	[]	-7	hSpCas9	negative selection	2878020
136545744	136545767	9	+	27260157	SF268	viability	GCAGCAGCGCCAGGCAGAGCAGG	NOTCH1	ENSG00000148400	0.023671044967266	[]	[]	0	hSpCas9	negative selection	2878472
136545721	136545744	9	+	27260157	SF268	viability	CCTACCTCGTGCGGCGAGCGCGG	NOTCH1	ENSG00000148400	-0.326655961954979	[]	[]	-3	hSpCas9	negative selection	2881598
136544053	136544076	9	+	27260157	SF268	viability	ACACTTCCCGCCATTCAGGCAGG	NOTCH1	ENSG00000148400	0.700540210421148	[]	[]	8	hSpCas9	negative selection	2883894
136545712	136545735	9	+	27260157	SF268	viability	GGGTGGGCGCCTACCTCGTGCGG	NOTCH1	ENSG00000148400	-0.741192837252306	[]	[]	-5	hSpCas9	negative selection	2890800
136544078	136544101	9	+	27260157	SF268	viability	TCACCGGGCTGGGAGCATCGCGG	NOTCH1	ENSG00000148400	-0.423130961195077	[]	[]	-3	hSpCas9	negative selection	2909578
136544031	136544054	9	-	27260157	SF268	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	-0.120471341098181	[]	[]	-1	hSpCas9	negative selection	2910004
136523946	136523969	9	+	27260157	SF268	viability	CTGGCATCGCGGGCCCACGAAGG	NOTCH1	ENSG00000148400	0.170885399720055	[]	[]	0	hSpCas9	negative selection	2914366
136523969	136523992	9	-	27260157	SF268	viability	ATCTGCCAACAGCTGTGGCGGGG	NOTCH1	ENSG00000148400	0.121367023052495	[]	[]	0	hSpCas9	negative selection	2914517
136544023	136544046	9	+	27260157	SF268	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.403322909835714	[]	[]	4	hSpCas9	negative selection	2921711
136523898	136523921	9	+	27260157	SF268	viability	GCATGTCCCGGCGTTCTTGCAGG	NOTCH1	ENSG00000148400	0.16549144310717	[]	[]	0	hSpCas9	negative selection	2926059
136523888	136523911	9	-	27260157	SF268	viability	CGCCGGGACATGCCACGTGGTGG	NOTCH1	ENSG00000148400	-0.499415431998968	[]	[]	-4	hSpCas9	negative selection	2926165
136544039	136544062	9	-	27260157	SF268	viability	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	0.636828408138088	[]	[]	8	hSpCas9	negative selection	2928074
136523886	136523909	9	+	27260157	SF268	viability	GTCCACCACGTGGCATGTCCCGG	NOTCH1	ENSG00000148400	-0.221147823758455	[]	[]	-2	hSpCas9	negative selection	2945743
136523945	136523968	9	-	27260157	SF268	viability	CTTCGTGGGCCCGCGATGCCAGG	NOTCH1	ENSG00000148400	1.67874586169115	[]	[]	9	hSpCas9	negative selection	2947058
136545771	136545794	9	-	27260157	SF268	viability	GGGAGGCATGCCGCCGCTCCTGG	NOTCH1	ENSG00000148400	-0.0630283672279529	[]	[]	0	hSpCas9	negative selection	2950341
136544067	136544090	9	+	27260157	SF268	viability	TCAGGCAGGTCTCACCGGGCTGG	NOTCH1	ENSG00000148400	-0.687514677699481	[]	[]	-5	hSpCas9	negative selection	2954150
136507402	136507425	9	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CCTCAGAGCAGTTCACCCCGTGG	NOTCH1	ENSG00000148400	-0.07331467042190207	[4,3]	[2,3]	-1	hSpCas9	positive selection	3006092
136507416	136507439	9	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTGCGTGGCCGGCTACCACGGGG	NOTCH1	ENSG00000148400	0.6655213048217069	[3,4]	[4,6]	9	hSpCas9	positive selection	3006093
136517272	136517295	9	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTTCCAGTGCGAGTGCCCCACGG	NOTCH1	ENSG00000148400	0.22909076187609756	[3,3]	[2,3]	5	hSpCas9	positive selection	3006094
136506950	136506973	9	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TGTGCACTGTGAGATCAACGTGG	NOTCH1	ENSG00000148400	-0.2926717832449687	[4,4]	[3,2]	-4	hSpCas9	positive selection	3006095
136507402	136507425	9	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CCTCAGAGCAGTTCACCCCGTGG	NOTCH1	ENSG00000148400	-0.7067715699534526	[4,4]	[3,0]	-8	hSpCas9	positive selection	3073950
136507416	136507439	9	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTGCGTGGCCGGCTACCACGGGG	NOTCH1	ENSG00000148400	0.2842361015146757	[3,3]	[3,3]	5	hSpCas9	positive selection	3073951
136517272	136517295	9	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTTCCAGTGCGAGTGCCCCACGG	NOTCH1	ENSG00000148400	-0.3665178527182041	[3,3]	[3,0]	-5	hSpCas9	positive selection	3073952
136506950	136506973	9	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TGTGCACTGTGAGATCAACGTGG	NOTCH1	ENSG00000148400	-0.11466160661841346	[4,4]	[3,1]	-2	hSpCas9	positive selection	3073953
136544023	136544046		+	24336571	A375	resistance to PLX after 7 days	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	-0.15172168299620178	[16,12]	[12,13]	-5	hSpCas9	positive selection	3131194
136523144	136523167		+	24336571	A375	resistance to PLX after 7 days	CGCAGGGGTTGGAGGCGCACGGG	NOTCH1	ENSG00000148400	0.06929159629687442	[12,13]	[13,13]	2	hSpCas9	positive selection	3131196
136523044	136523067		-	24336571	A375	resistance to PLX after 7 days	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.3614706969073295	[13,12]	[9,9]	-8	hSpCas9	positive selection	3131197
136544078	136544101		+	24336571	A375	resistance to PLX after 7 days	TCACCGGGCTGGGAGCATCGCGG	NOTCH1	ENSG00000148400	-0.0287984026053425	[19,20]	[16,22]	-1	hSpCas9	positive selection	3131198
136544023	136544046		+	24336571	A375	resistance to PLX after 14 days	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	-0.6838828312587478	[19,18]	[3,5]	-7	hSpCas9	positive selection	3188987
136523144	136523167		+	24336571	A375	resistance to PLX after 14 days	CGCAGGGGTTGGAGGCGCACGGG	NOTCH1	ENSG00000148400	-0.8966421063013523	[10,10]	[2,1]	-9	hSpCas9	positive selection	3188989
136523044	136523067		-	24336571	A375	resistance to PLX after 14 days	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.3994541419041163	[11,16]	[2,5]	-5	hSpCas9	positive selection	3188990
136544078	136544101		+	24336571	A375	resistance to PLX after 14 days	TCACCGGGCTGGGAGCATCGCGG	NOTCH1	ENSG00000148400	-0.6473504125108347	[16,17]	[4,4]	-7	hSpCas9	positive selection	3188991
136544023	136544046		+	24336571	A375	viability after 7 days	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.27767148511695167	[12]	[16,12]	4	hSpCas9	negative selection	3246780
136523144	136523167		+	24336571	A375	viability after 7 days	CGCAGGGGTTGGAGGCGCACGGG	NOTCH1	ENSG00000148400	-0.05278937448518541	[13]	[12,13]	0	hSpCas9	negative selection	3246782
136523044	136523067		-	24336571	A375	viability after 7 days	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	0.16478391245252	[12]	[13,12]	2	hSpCas9	negative selection	3246783
136544078	136544101		+	24336571	A375	viability after 7 days	TCACCGGGCTGGGAGCATCGCGG	NOTCH1	ENSG00000148400	0.5252094839978135	[14]	[19,20]	7	hSpCas9	negative selection	3246784
136544023	136544046		+	24336571	A375	viability after 14 days	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.6455943112081506	[12]	[19,18]	7	hSpCas9	negative selection	3304573
136523144	136523167		+	24336571	A375	viability after 14 days	CGCAGGGGTTGGAGGCGCACGGG	NOTCH1	ENSG00000148400	-0.25872339608480527	[13]	[10,10]	-3	hSpCas9	negative selection	3304575
136523044	136523067		-	24336571	A375	viability after 14 days	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	0.27834349606428005	[12]	[11,16]	3	hSpCas9	negative selection	3304576
136544078	136544101		+	24336571	A375	viability after 14 days	TCACCGGGCTGGGAGCATCGCGG	NOTCH1	ENSG00000148400	0.33850311859846344	[14]	[16,17]	4	hSpCas9	negative selection	3304577
136518750	136518773	9	+	27383988	293T	resistance to West Nile virus (flavivirus)	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	-0.8459615969661868	[274,274]	[0,0]	-6	hSpCas9	positive selection	3382079
136544023	136544046	9	+	27383988	293T	resistance to West Nile virus (flavivirus)	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	-1.2504684287528613	[363,363]	[0,0]	-8	hSpCas9	positive selection	3382080
136544049	136544072	9	+	27383988	293T	resistance to West Nile virus (flavivirus)	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	-2.1752156889424232	[690,690]	[0,0]	-9	hSpCas9	positive selection	3382081
136507401	136507424	9	+	26780180	HT29	viability (Avana library 4 designs)	CCTCAGAGCAGTTCACCCCGTGG	NOTCH1	ENSG00000148400	0.778092325924782	[]	[]	3	hSpCas9	negative selection	3443950
136507416	136507439	9	-	26780180	HT29	viability (Avana library 4 designs)	GTGCGTGGCCGGCTACCACGGGG	NOTCH1	ENSG00000148400	0.400792596266455	[]	[]	1	hSpCas9	negative selection	3443951
136517272	136517295	9	-	26780180	HT29	viability (Avana library 4 designs)	GTTCCAGTGCGAGTGCCCCACGG	NOTCH1	ENSG00000148400	1.67329575885626	[]	[]	6	hSpCas9	negative selection	3443952
136506950	136506973	9	-	26780180	HT29	viability (Avana library 4 designs)	TGTGCACTGTGAGATCAACGTGG	NOTCH1	ENSG00000148400	0.996158982832096	[]	[]	4	hSpCas9	negative selection	3443953
136517272	136517295	9	-	26780180	A375	viability (Avana lentiCRISPRv2)	GTTCCAGTGCGAGTGCCCCACGG	NOTCH1	ENSG00000148400	2.32668180123534	[]	[]	3	hSpCas9	negative selection	3535895
136507416	136507439	9	-	26780180	A375	viability (Avana lentiCRISPRv2)	GTGCGTGGCCGGCTACCACGGGG	NOTCH1	ENSG00000148400	6.4943735256203	[]	[]	9	hSpCas9	negative selection	3535896
136506950	136506973	9	-	26780180	A375	viability (Avana lentiCRISPRv2)	TGTGCACTGTGAGATCAACGTGG	NOTCH1	ENSG00000148400	0.0603508905354294	[]	[]	0	hSpCas9	negative selection	3535897
136507401	136507424	9	+	26780180	A375	viability (Avana lentiCRISPRv2)	CCTCAGAGCAGTTCACCCCGTGG	NOTCH1	ENSG00000148400	5.82299639503362	[]	[]	9	hSpCas9	negative selection	3535898
136518807	136518830	9	-	26780180	A375	viability (Avana lentiCRISPRv2)	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	4.04291845657274	[]	[]	6	hSpCas9	negative selection	3535899
136519499	136519522	9	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	-4.63767503917987	[]	[]	-5	hSpCas9	negative selection	3535900
136517272	136517295	9	-	26780180	A375	viability (Avana lentiGuide)	GTTCCAGTGCGAGTGCCCCACGG	NOTCH1	ENSG00000148400	-5.53066544957758	[]	[]	-8	hSpCas9	negative selection	3644554
136507416	136507439	9	-	26780180	A375	viability (Avana lentiGuide)	GTGCGTGGCCGGCTACCACGGGG	NOTCH1	ENSG00000148400	1.35936221956365	[]	[]	1	hSpCas9	negative selection	3644555
136506950	136506973	9	-	26780180	A375	viability (Avana lentiGuide)	TGTGCACTGTGAGATCAACGTGG	NOTCH1	ENSG00000148400	-0.459500542625213	[]	[]	0	hSpCas9	negative selection	3644556
136507401	136507424	9	+	26780180	A375	viability (Avana lentiGuide)	CCTCAGAGCAGTTCACCCCGTGG	NOTCH1	ENSG00000148400	0.259954641043673	[]	[]	0	hSpCas9	negative selection	3644557
136518807	136518830	9	-	26780180	A375	viability (Avana lentiGuide)	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.988181980592356	[]	[]	-1	hSpCas9	negative selection	3644558
136519499	136519522	9	-	26780180	A375	viability (Avana lentiGuide)	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	-1.01233336138356	[]	[]	-1	hSpCas9	negative selection	3644559
136517272	136517295	9	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTTCCAGTGCGAGTGCCCCACGG	NOTCH1	ENSG00000148400	0.132026552284011	[5]	[6,4]	3	hSpCas9	positive selection	3753213
136507416	136507439	9	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTGCGTGGCCGGCTACCACGGGG	NOTCH1	ENSG00000148400	0.28657676244295827	[5]	[7,6]	8	hSpCas9	positive selection	3753214
136506950	136506973	9	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGTGCACTGTGAGATCAACGTGG	NOTCH1	ENSG00000148400	0.03433164165321556	[5]	[5,5]	0	hSpCas9	positive selection	3753215
136507401	136507424	9	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CCTCAGAGCAGTTCACCCCGTGG	NOTCH1	ENSG00000148400	0.3268998004935332	[4]	[5,5]	8	hSpCas9	positive selection	3753216
136518807	136518830	9	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	0.22851889440317366	[6]	[7,6]	6	hSpCas9	positive selection	3753217
136519499	136519522	9	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	-0.39197101226947084	[4]	[2,3]	-5	hSpCas9	positive selection	3753218
136517272	136517295	9	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTTCCAGTGCGAGTGCCCCACGG	NOTCH1	ENSG00000148400	-0.11642912784331823	[5]	[4,3]	-2	hSpCas9	positive selection	3861820
136507416	136507439	9	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTGCGTGGCCGGCTACCACGGGG	NOTCH1	ENSG00000148400	-0.3314367700570815	[6]	[3,4]	-4	hSpCas9	positive selection	3861821
136506950	136506973	9	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGTGCACTGTGAGATCAACGTGG	NOTCH1	ENSG00000148400	0.12512839434547507	[6]	[5,6]	3	hSpCas9	positive selection	3861822
136507401	136507424	9	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CCTCAGAGCAGTTCACCCCGTGG	NOTCH1	ENSG00000148400	0.03554945796822487	[5]	[5,3]	0	hSpCas9	positive selection	3861823
136518807	136518830	9	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	0.206115609773731	[6]	[6,6]	5	hSpCas9	positive selection	3861824
136519499	136519522	9	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	0.20566954505953555	[4]	[6,2]	5	hSpCas9	positive selection	3861825
136544023	136544046	9	+	26780180	A375	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	1.14373379246311	[]	[]	6	hSpCas9	negative selection	3973142
136523044	136523067	9	-	26780180	A375	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	1.29242914943838	[]	[]	7	hSpCas9	negative selection	3973143
136544049	136544072	9	+	26780180	A375	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.129785432539637	[]	[]	0	hSpCas9	negative selection	3973144
136522993	136523016	9	-	26780180	A375	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	0.955373961772012	[]	[]	4	hSpCas9	negative selection	3973145
136518807	136518830	9	-	26780180	A375	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	1.52234073428488	[]	[]	8	hSpCas9	negative selection	3973146
136518750	136518773	9	+	26780180	A375	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	1.24031719768848	[]	[]	6	hSpCas9	negative selection	3973147
136544023	136544046	9	+	26780180	HT29	viability (GeCKOv2 library)	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	1.29954814218914	[]	[]	6	hSpCas9	negative selection	4081108
136523044	136523067	9	-	26780180	HT29	viability (GeCKOv2 library)	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	1.65064813945375	[]	[]	8	hSpCas9	negative selection	4081109
136544049	136544072	9	+	26780180	HT29	viability (GeCKOv2 library)	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.73785577561151	[]	[]	3	hSpCas9	negative selection	4081110
136522993	136523016	9	-	26780180	HT29	viability (GeCKOv2 library)	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	1.62670497349513	[]	[]	8	hSpCas9	negative selection	4081111
136518807	136518830	9	-	26780180	HT29	viability (GeCKOv2 library)	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	1.49253677110686	[]	[]	7	hSpCas9	negative selection	4081112
136518750	136518773	9	+	26780180	HT29	viability (GeCKOv2 library)	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	1.61579497960939	[]	[]	8	hSpCas9	negative selection	4081113
136544023	136544046	9	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	-0.09400098461223842	[3]	[2,2]	-2	hSpCas9	positive selection	4155884
136523144	136523167	9	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CGCAGGGGTTGGAGGCGCACGGG	NOTCH1	ENSG00000148400	-0.16700018711190306	[3]	[2,0]	-4	hSpCas9	positive selection	4155886
136523044	136523067	9	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.2404063956923573	[3]	[1,1]	-5	hSpCas9	positive selection	4155887
136544078	136544101	9	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TCACCGGGCTGGGAGCATCGCGG	NOTCH1	ENSG00000148400	-0.20362820589755148	[4]	[2,2]	-5	hSpCas9	positive selection	4155888
136544023	136544046	9	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	-0.3894046790758428	[4]	[0,3,1,0]	-5	hSpCas9	positive selection	4219906
136523144	136523167	9	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CGCAGGGGTTGGAGGCGCACGGG	NOTCH1	ENSG00000148400	0.02017668959054826	[3]	[2,1,1,0]	0	hSpCas9	positive selection	4219908
136523044	136523067	9	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.3496639490686392	[3]	[0,0,2,0]	-5	hSpCas9	positive selection	4219909
136544078	136544101	9	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TCACCGGGCTGGGAGCATCGCGG	NOTCH1	ENSG00000148400	-0.1963858486637588	[4]	[1,2,1,0]	-3	hSpCas9	positive selection	4219910
136522993	136523016	9	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.019963313764352397	[3]	[3,1]	0	hSpCas9	positive selection	4285995
136523044	136523067	9	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.28590870608665797	[2]	[1,0]	-5	hSpCas9	positive selection	4285996
136518807	136518830	9	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.5237812752426513	[3]	[2,0]	-8	hSpCas9	positive selection	4285997
136518750	136518773	9	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	-0.2649042810008747	[3]	[2,1]	-5	hSpCas9	positive selection	4350252
136544023	136544046	9	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.05825387743232374	[4]	[3,2]	1	hSpCas9	positive selection	4350253
136544049	136544072	9	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.41613236069621523	[4]	[4,4]	8	hSpCas9	positive selection	4350254
136509944	136509966	9	+	27760321	OCIAML3	viability	CCCCGTTGTGACACGGGTCTGG	NOTCH1	ENSG00000148400	-0.028028180897967103	[691,635]	[457,575]	0	hSpCas9	negative selection	4422993
136510657	136510679	9	-	27760321	OCIAML3	viability	GACCGACATCGACGACTGCCGG	NOTCH1	ENSG00000148400	0.11833333607243413	[1082,938]	[905,790]	1	hSpCas9	negative selection	4422994
136517834	136517856	9	+	27760321	OCIAML3	viability	GACGTCGATCTCGCATCGGGGG	NOTCH1	ENSG00000148400	-0.15224005460230183	[968,904]	[578,764]	-2	hSpCas9	negative selection	4422995
136519434	136519456	9	+	27760321	OCIAML3	viability	TATACGCGCCTGTCCACTCTGG	NOTCH1	ENSG00000148400	-0.6120607381097212	[1035,834]	[360,625]	-5	hSpCas9	negative selection	4422996
136523745	136523767	9	+	27760321	OCIAML3	viability	GTACTCCGTCAGCGTGAGCAGG	NOTCH1	ENSG00000148400	-0.2514294129390476	[519,433]	[292,336]	-3	hSpCas9	negative selection	4422997
136509944	136509966	9	+	27760321	OCIAML2	viability	CCCCGTTGTGACACGGGTCTGG	NOTCH1	ENSG00000148400	0.3149637488115695	[691,635]	[696,629]	4	hSpCas9	negative selection	4506456
136510657	136510679	9	-	27760321	OCIAML2	viability	GACCGACATCGACGACTGCCGG	NOTCH1	ENSG00000148400	-0.39345632092482963	[1082,938]	[551,711]	-4	hSpCas9	negative selection	4506457
136517834	136517856	9	+	27760321	OCIAML2	viability	GACGTCGATCTCGCATCGGGGG	NOTCH1	ENSG00000148400	-0.5223383674334359	[968,904]	[464,610]	-5	hSpCas9	negative selection	4506458
136519434	136519456	9	+	27760321	OCIAML2	viability	TATACGCGCCTGTCCACTCTGG	NOTCH1	ENSG00000148400	-0.1614654252601958	[1035,834]	[602,764]	-2	hSpCas9	negative selection	4506459
136523745	136523767	9	+	27760321	OCIAML2	viability	GTACTCCGTCAGCGTGAGCAGG	NOTCH1	ENSG00000148400	-0.07999032286564972	[519,433]	[385,333]	-1	hSpCas9	negative selection	4506460
136509944	136509966	9	+	27760321	MV411	viability	CCCCGTTGTGACACGGGTCTGG	NOTCH1	ENSG00000148400	0.3395224278032083	[691,635]	[481,662]	2	hSpCas9	negative selection	4589919
136510657	136510679	9	-	27760321	MV411	viability	GACCGACATCGACGACTGCCGG	NOTCH1	ENSG00000148400	-0.10059011903126325	[1082,938]	[419,921]	0	hSpCas9	negative selection	4589920
136517834	136517856	9	+	27760321	MV411	viability	GACGTCGATCTCGCATCGGGGG	NOTCH1	ENSG00000148400	1.400516644507337	[968,904]	[1806,1371]	8	hSpCas9	negative selection	4589921
136519434	136519456	9	+	27760321	MV411	viability	TATACGCGCCTGTCCACTCTGG	NOTCH1	ENSG00000148400	-0.5167790962629447	[1035,834]	[534,269]	-4	hSpCas9	negative selection	4589922
136523745	136523767	9	+	27760321	MV411	viability	GTACTCCGTCAGCGTGAGCAGG	NOTCH1	ENSG00000148400	-1.2572968771738826	[519,433]	[53,246]	-7	hSpCas9	negative selection	4589923
136509944	136509966	9	+	27760321	HL60	viability	CCCCGTTGTGACACGGGTCTGG	NOTCH1	ENSG00000148400	0.6025216057026981	[691,635]	[936,702]	7	hSpCas9	negative selection	4673382
136510657	136510679	9	-	27760321	HL60	viability	GACCGACATCGACGACTGCCGG	NOTCH1	ENSG00000148400	0.3051435694403024	[1082,938]	[943,1095]	4	hSpCas9	negative selection	4673383
136517834	136517856	9	+	27760321	HL60	viability	GACGTCGATCTCGCATCGGGGG	NOTCH1	ENSG00000148400	0.09142814435746294	[968,904]	[927,696]	1	hSpCas9	negative selection	4673384
136519434	136519456	9	+	27760321	HL60	viability	TATACGCGCCTGTCCACTCTGG	NOTCH1	ENSG00000148400	-0.6292653857464808	[1035,834]	[534,444]	-6	hSpCas9	negative selection	4673385
136523745	136523767	9	+	27760321	HL60	viability	GTACTCCGTCAGCGTGAGCAGG	NOTCH1	ENSG00000148400	0.3280504958977041	[519,433]	[457,517]	4	hSpCas9	negative selection	4673386
136509944	136509966	9	+	27760321	HT1080	viability	CCCCGTTGTGACACGGGTCTGG	NOTCH1	ENSG00000148400	1.3186808340692031	[635,495]	[612,506]	7	hSpCas9	negative selection	4756845
136510657	136510679	9	-	27760321	HT1080	viability	GACCGACATCGACGACTGCCGG	NOTCH1	ENSG00000148400	-0.6076676935942037	[938,732]	[261,170]	-3	hSpCas9	negative selection	4756846
136517834	136517856	9	+	27760321	HT1080	viability	GACGTCGATCTCGCATCGGGGG	NOTCH1	ENSG00000148400	-0.8174535662314895	[904,705]	[109,260]	-3	hSpCas9	negative selection	4756847
136519434	136519456	9	+	27760321	HT1080	viability	TATACGCGCCTGTCCACTCTGG	NOTCH1	ENSG00000148400	-1.6620425718760616	[834,651]	[63,125]	-5	hSpCas9	negative selection	4756848
136523745	136523767	9	+	27760321	HT1080	viability	GTACTCCGTCAGCGTGAGCAGG	NOTCH1	ENSG00000148400	0.5825979179234306	[433,338]	[242,216]	3	hSpCas9	negative selection	4756849
136509944	136509966	9	+	27760321	HT29	viability after 7 days	CCCCGTTGTGACACGGGTCTGG	NOTCH1	ENSG00000148400	0.08967268860527511	[635,495]	[688,949,673]	1	hSpCas9	negative selection	4840308
136510657	136510679	9	-	27760321	HT29	viability after 7 days	GACCGACATCGACGACTGCCGG	NOTCH1	ENSG00000148400	0.17514412898425813	[938,732]	[1419,891,1351]	2	hSpCas9	negative selection	4840309
136517834	136517856	9	+	27760321	HT29	viability after 7 days	GACGTCGATCTCGCATCGGGGG	NOTCH1	ENSG00000148400	-0.33205575841494717	[904,705]	[823,817,824]	-5	hSpCas9	negative selection	4840310
136519434	136519456	9	+	27760321	HT29	viability after 7 days	TATACGCGCCTGTCCACTCTGG	NOTCH1	ENSG00000148400	-0.2156935785370302	[834,651]	[1206,710,611]	-3	hSpCas9	negative selection	4840311
136523745	136523767	9	+	27760321	HT29	viability after 7 days	GTACTCCGTCAGCGTGAGCAGG	NOTCH1	ENSG00000148400	-0.02685541545475642	[433,338]	[622,404,454]	0	hSpCas9	negative selection	4840312
136509944	136509966	9	+	27760321	HT29	viability after 25 days	CCCCGTTGTGACACGGGTCTGG	NOTCH1	ENSG00000148400	0.4793416988493143	[635,495]	[784,973,957]	5	hSpCas9	negative selection	4923771
136510657	136510679	9	-	27760321	HT29	viability after 25 days	GACCGACATCGACGACTGCCGG	NOTCH1	ENSG00000148400	0.00023243598981004254	[938,732]	[935,823,1123]	0	hSpCas9	negative selection	4923772
136517834	136517856	9	+	27760321	HT29	viability after 25 days	GACGTCGATCTCGCATCGGGGG	NOTCH1	ENSG00000148400	-1.247480966297736	[904,705]	[376,451,327]	-7	hSpCas9	negative selection	4923773
136519434	136519456	9	+	27760321	HT29	viability after 25 days	TATACGCGCCTGTCCACTCTGG	NOTCH1	ENSG00000148400	-0.06983465616570861	[834,651]	[831,715,885]	0	hSpCas9	negative selection	4923774
136523745	136523767	9	+	27760321	HT29	viability after 25 days	GTACTCCGTCAGCGTGAGCAGG	NOTCH1	ENSG00000148400	-0.28234464312682717	[433,338]	[570,201,295]	-3	hSpCas9	negative selection	4923775
136509944	136509966	9	+	27760321	HT29	viability after 22 days	CCCCGTTGTGACACGGGTCTGG	NOTCH1	ENSG00000148400	0.2447937709611353	[635,495]	[695,853,777]	2	hSpCas9	negative selection	5007234
136510657	136510679	9	-	27760321	HT29	viability after 22 days	GACCGACATCGACGACTGCCGG	NOTCH1	ENSG00000148400	0.17408921942043132	[938,732]	[1151,875,1242]	1	hSpCas9	negative selection	5007235
136517834	136517856	9	+	27760321	HT29	viability after 22 days	GACGTCGATCTCGCATCGGGGG	NOTCH1	ENSG00000148400	-1.030370559195761	[904,705]	[444,564,356]	-6	hSpCas9	negative selection	5007236
136519434	136519456	9	+	27760321	HT29	viability after 22 days	TATACGCGCCTGTCCACTCTGG	NOTCH1	ENSG00000148400	0.02693700513225905	[834,651]	[1201,894,517]	0	hSpCas9	negative selection	5007237
136523745	136523767	9	+	27760321	HT29	viability after 22 days	GTACTCCGTCAGCGTGAGCAGG	NOTCH1	ENSG00000148400	0.5010731694625818	[433,338]	[907,526,452]	5	hSpCas9	negative selection	5007238
136509944	136509966	9	+	27760321	HT29	viability after 19 days	CCCCGTTGTGACACGGGTCTGG	NOTCH1	ENSG00000148400	0.7858943404550619	[635,495]	[995,1335,1006]	7	hSpCas9	negative selection	5090697
136510657	136510679	9	-	27760321	HT29	viability after 19 days	GACCGACATCGACGACTGCCGG	NOTCH1	ENSG00000148400	0.0289771422916707	[938,732]	[1158,887,900]	0	hSpCas9	negative selection	5090698
136517834	136517856	9	+	27760321	HT29	viability after 19 days	GACGTCGATCTCGCATCGGGGG	NOTCH1	ENSG00000148400	-0.3815460498914591	[904,705]	[606,623,872]	-4	hSpCas9	negative selection	5090699
136519434	136519456	9	+	27760321	HT29	viability after 19 days	TATACGCGCCTGTCCACTCTGG	NOTCH1	ENSG00000148400	0.05658774516307852	[834,651]	[1037,569,1053]	0	hSpCas9	negative selection	5090700
136523745	136523767	9	+	27760321	HT29	viability after 19 days	GTACTCCGTCAGCGTGAGCAGG	NOTCH1	ENSG00000148400	0.3001121063376325	[433,338]	[444,1059,132]	3	hSpCas9	negative selection	5090701
136509944	136509966	9	+	27760321	HT29	viability after 16 days	CCCCGTTGTGACACGGGTCTGG	NOTCH1	ENSG00000148400	0.22056119357387427	[635,495]	[484,945,752]	2	hSpCas9	negative selection	5174160
136510657	136510679	9	-	27760321	HT29	viability after 16 days	GACCGACATCGACGACTGCCGG	NOTCH1	ENSG00000148400	0.06865783558869243	[938,732]	[904,805,1228]	0	hSpCas9	negative selection	5174161
136517834	136517856	9	+	27760321	HT29	viability after 16 days	GACGTCGATCTCGCATCGGGGG	NOTCH1	ENSG00000148400	-0.6799273281743128	[904,705]	[778,404,527]	-6	hSpCas9	negative selection	5174162
136519434	136519456	9	+	27760321	HT29	viability after 16 days	TATACGCGCCTGTCCACTCTGG	NOTCH1	ENSG00000148400	0.10231151750152567	[834,651]	[1052,1158,474]	1	hSpCas9	negative selection	5174163
136523745	136523767	9	+	27760321	HT29	viability after 16 days	GTACTCCGTCAGCGTGAGCAGG	NOTCH1	ENSG00000148400	0.2049523362957245	[433,338]	[524,604,364]	2	hSpCas9	negative selection	5174164
136509944	136509966	9	+	27760321	HT29	viability after 13 days	CCCCGTTGTGACACGGGTCTGG	NOTCH1	ENSG00000148400	0.15268010219101236	[635,495]	[408,739,1022]	1	hSpCas9	negative selection	5257623
136510657	136510679	9	-	27760321	HT29	viability after 13 days	GACCGACATCGACGACTGCCGG	NOTCH1	ENSG00000148400	0.15926996899473433	[938,732]	[1042,1274,939]	2	hSpCas9	negative selection	5257624
136517834	136517856	9	+	27760321	HT29	viability after 13 days	GACGTCGATCTCGCATCGGGGG	NOTCH1	ENSG00000148400	-0.5258788642557528	[904,705]	[644,756,550]	-5	hSpCas9	negative selection	5257625
136519434	136519456	9	+	27760321	HT29	viability after 13 days	TATACGCGCCTGTCCACTCTGG	NOTCH1	ENSG00000148400	0.10650612994240527	[834,651]	[849,1041,895]	1	hSpCas9	negative selection	5257626
136523745	136523767	9	+	27760321	HT29	viability after 13 days	GTACTCCGTCAGCGTGAGCAGG	NOTCH1	ENSG00000148400	-0.4377397673706056	[433,338]	[475,223,294]	-5	hSpCas9	negative selection	5257627
136509944	136509966	9	+	27760321	HT29	viability after 10 days	CCCCGTTGTGACACGGGTCTGG	NOTCH1	ENSG00000148400	-0.1633129793641237	[635,495]	[588,730,576]	-2	hSpCas9	negative selection	5341086
136510657	136510679	9	-	27760321	HT29	viability after 10 days	GACCGACATCGACGACTGCCGG	NOTCH1	ENSG00000148400	0.2580694616894499	[938,732]	[1408,1304,1036]	3	hSpCas9	negative selection	5341087
136517834	136517856	9	+	27760321	HT29	viability after 10 days	GACGTCGATCTCGCATCGGGGG	NOTCH1	ENSG00000148400	-0.3746250991080319	[904,705]	[898,841,591]	-5	hSpCas9	negative selection	5341088
136519434	136519456	9	+	27760321	HT29	viability after 10 days	TATACGCGCCTGTCCACTCTGG	NOTCH1	ENSG00000148400	-0.3605613763740836	[834,651]	[816,660,689]	-5	hSpCas9	negative selection	5341089
136523745	136523767	9	+	27760321	HT29	viability after 10 days	GTACTCCGTCAGCGTGAGCAGG	NOTCH1	ENSG00000148400	-0.5009215805943364	[433,338]	[390,197,427]	-6	hSpCas9	negative selection	5341090
136509944	136509966	9	+	27760321	MOLM13	viability	CCCCGTTGTGACACGGGTCTGG	NOTCH1	ENSG00000148400	0.847440749444105	[691,635]	[788,575]	6	hSpCas9	negative selection	5424549
136510657	136510679	9	-	27760321	MOLM13	viability	GACCGACATCGACGACTGCCGG	NOTCH1	ENSG00000148400	0.6571205178256772	[1082,938]	[1035,778]	4	hSpCas9	negative selection	5424550
136517834	136517856	9	+	27760321	MOLM13	viability	GACGTCGATCTCGCATCGGGGG	NOTCH1	ENSG00000148400	0.17759874566059475	[968,904]	[561,628]	1	hSpCas9	negative selection	5424551
136519434	136519456	9	+	27760321	MOLM13	viability	TATACGCGCCTGTCCACTCTGG	NOTCH1	ENSG00000148400	0.08908969879925599	[1035,834]	[701,435]	0	hSpCas9	negative selection	5424552
136523745	136523767	9	+	27760321	MOLM13	viability	GTACTCCGTCAGCGTGAGCAGG	NOTCH1	ENSG00000148400	2.146697796451487	[519,433]	[2473,90]	9	hSpCas9	negative selection	5424553
136523886	136523909	9	+	27661255	K562	viability	GTCCACCACGTGGCATGTCCCGG	NOTCH1	ENSG00000148400	0.17330337163570694	[826,934]	[834,754]	6	dCas9-KRAB	negative selection	5497086
136545550	136545573	9	+	27661255	K562	viability	GGTCGGTCCTCCCTGATCCCGGG	NOTCH1	ENSG00000148400	-0.057312382879807	[1708,1453]	[1330,1120]	-2	dCas9-KRAB	negative selection	5497087
136545664	136545687	9	+	27661255	K562	viability	GGCGCCGCCAAAGTTTCCAAAGG	NOTCH1	ENSG00000148400	0.2667662423495095	[382,422]	[418,358]	8	dCas9-KRAB	negative selection	5497088
136545777	136545800	9	+	27661255	K562	viability	GCGGCGGCATGCCTCCCCACCGG	NOTCH1	ENSG00000148400	0.02277790040856592	[536,729]	[581,450]	0	dCas9-KRAB	negative selection	5497089
136523891	136523914	9	-	27661255	K562	viability	GAACGCCGGGACATGCCACGTGG	NOTCH1	ENSG00000148400	0.22916239800913407	[1173,1535]	[1355,1182]	7	dCas9-KRAB	negative selection	5497090
136522993	136523016	9	-	27260156	BXPC3	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.646704237836432	[761]	[483,499,524,528]	-8	hSpCas9	negative selection	5558455
136523044	136523067	9	-	27260156	BXPC3	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.23111924339054313	[298]	[382,190,223,254]	-5	hSpCas9	negative selection	5558456
136518807	136518830	9	-	27260156	BXPC3	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.7694811037532276	[467]	[326,261,265,287]	-9	hSpCas9	negative selection	5558457
136518750	136518773	9	+	27260156	BXPC3	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	-0.07712738670828356	[568]	[545,557,491,669]	-2	hSpCas9	negative selection	5622712
136544023	136544046	9	+	27260156	BXPC3	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.16086459849798707	[1005]	[883,1258,1246,1355]	3	hSpCas9	negative selection	5622713
136544049	136544072	9	+	27260156	BXPC3	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.3480430580636886	[1399]	[1852,1805,1880,1909]	7	hSpCas9	negative selection	5622714
136522993	136523016	9	-	27260156	A673	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.07646558744428622	[761]	[944,821,807,906]	-2	hSpCas9	negative selection	5679706
136523044	136523067	9	-	27260156	A673	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.2773222024431975	[298]	[248,371,277,276]	-6	hSpCas9	negative selection	5679707
136518807	136518830	9	-	27260156	A673	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.2542731461957075	[467]	[597,414,462,420]	-6	hSpCas9	negative selection	5679708
136518750	136518773	9	+	27260156	A673	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	0.0742927431068407	[568]	[823,710,603,751]	1	hSpCas9	negative selection	5743963
136544023	136544046	9	+	27260156	A673	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.04279843840504238	[1005]	[1345,1357,1056,1222]	1	hSpCas9	negative selection	5743964
136544049	136544072	9	+	27260156	A673	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.49578153118574675	[1399]	[2839,2104,2212,2381]	9	hSpCas9	negative selection	5743965
136522993	136523016	9	-	27260156	A375	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.2777363544505324	[761]	[699,1042,716,539]	-4	hSpCas9	negative selection	5800957
136523044	136523067	9	-	27260156	A375	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.3843546803362319	[298]	[181,182,416,273]	-5	hSpCas9	negative selection	5800958
136518807	136518830	9	-	27260156	A375	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.2540206346634729	[467]	[478,412,460,470]	-4	hSpCas9	negative selection	5800959
136518750	136518773	9	+	27260156	A375	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	0.0783069296428065	[568]	[848,722,728,527]	1	hSpCas9	negative selection	5865214
136544023	136544046	9	+	27260156	A375	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.06475384665216444	[1005]	[1221,1281,1616,843]	0	hSpCas9	negative selection	5865215
136544049	136544072	9	+	27260156	A375	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.4629249048885764	[1399]	[2040,2498,2678,1866]	6	hSpCas9	negative selection	5865216
136522993	136523016	9	-	27260156	COLO741	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.13094818028038913	[761]	[1117,797,776]	-3	hSpCas9	negative selection	5922208
136523044	136523067	9	-	27260156	COLO741	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.552930244833276	[298]	[233,221,317]	-8	hSpCas9	negative selection	5922209
136518807	136518830	9	-	27260156	COLO741	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.15265048991781538	[467]	[588,422,599]	-3	hSpCas9	negative selection	5922210
136518750	136518773	9	+	27260156	COLO741	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	-0.12433493003396295	[568]	[654,683,659]	-3	hSpCas9	negative selection	5986465
136544023	136544046	9	+	27260156	COLO741	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.10453719528406547	[1005]	[1482,1492,1189]	2	hSpCas9	negative selection	5986466
136544049	136544072	9	+	27260156	COLO741	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.44120074929615094	[1399]	[2390,2352,2525]	8	hSpCas9	negative selection	5986467
136522993	136523016	9	-	27260156	CAL120	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.1312468328736568	[761]	[1291,666,704]	-2	hSpCas9	negative selection	6043459
136523044	136523067	9	-	27260156	CAL120	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	0.25301717698550363	[298]	[523,534,285]	4	hSpCas9	negative selection	6043460
136518807	136518830	9	-	27260156	CAL120	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.4633812948748125	[467]	[435,352,478]	-6	hSpCas9	negative selection	6043461
136518750	136518773	9	+	27260156	CAL120	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	0.3659421866854833	[568]	[1283,876,636]	5	hSpCas9	negative selection	6107716
136544023	136544046	9	+	27260156	CAL120	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.20238241873368557	[1005]	[1460,1665,1200]	3	hSpCas9	negative selection	6107717
136544049	136544072	9	+	27260156	CAL120	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.38643982034364366	[1399]	[2594,1913,2367]	6	hSpCas9	negative selection	6107718
136522993	136523016	9	-	27260156	CADOES1	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.3283040991221794	[761]	[499,603,591,561]	-5	hSpCas9	negative selection	6164710
136523044	136523067	9	-	27260156	CADOES1	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.15899213394501688	[298]	[229,249,249,266]	-3	hSpCas9	negative selection	6164711
136518807	136518830	9	-	27260156	CADOES1	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.6115059773710756	[467]	[325,238,221,354]	-8	hSpCas9	negative selection	6164712
136518750	136518773	9	+	27260156	CADOES1	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	0.021081196496489596	[568]	[485,588,566,504]	0	hSpCas9	negative selection	6228967
136544023	136544046	9	+	27260156	CADOES1	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.20956820068070536	[1005]	[1058,1280,859,1129]	3	hSpCas9	negative selection	6228968
136544049	136544072	9	+	27260156	CADOES1	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.6023233234072516	[1399]	[1614,2019,1735,2558]	8	hSpCas9	negative selection	6228969
136522993	136523016	9	-	27260156	EWS502	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.26918352279522445	[761]	[699,676,699,589]	-5	hSpCas9	negative selection	6285961
136523044	136523067	9	-	27260156	EWS502	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	0.09327081455744757	[298]	[241,251,438,440]	1	hSpCas9	negative selection	6285962
136518807	136518830	9	-	27260156	EWS502	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	0.20176417781806097	[467]	[379,779,298,849]	3	hSpCas9	negative selection	6285963
136518750	136518773	9	+	27260156	EWS502	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	-0.03525216430150907	[568]	[503,536,663,663]	0	hSpCas9	negative selection	6350218
136544023	136544046	9	+	27260156	EWS502	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.33555535494687083	[1005]	[1260,1081,1324,1754]	6	hSpCas9	negative selection	6350219
136544049	136544072	9	+	27260156	EWS502	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.564439083536717	[1399]	[2212,2136,2205,2207]	8	hSpCas9	negative selection	6350220
136522993	136523016	9	-	27260156	EW8	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.38663687692937954	[761]	[551,457,441,449]	-6	hSpCas9	negative selection	6407212
136523044	136523067	9	-	27260156	EW8	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.27834276055815554	[298]	[243,234,132,202]	-5	hSpCas9	negative selection	6407213
136518807	136518830	9	-	27260156	EW8	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.31656737611588254	[467]	[327,384,229,289]	-5	hSpCas9	negative selection	6407214
136518750	136518773	9	+	27260156	EW8	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	-0.011201265861125409	[568]	[424,480,489,423]	0	hSpCas9	negative selection	6471469
136544023	136544046	9	+	27260156	EW8	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.2129469869025309	[1005]	[925,1109,777,989]	4	hSpCas9	negative selection	6471470
136544049	136544072	9	+	27260156	EW8	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.6852835094083314	[1399]	[1981,1793,1667,1891]	9	hSpCas9	negative selection	6471471
136522993	136523016	9	-	27260156	CORL105	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.10462822660842608	[761]	[591,968,841,905]	-2	hSpCas9	negative selection	6528463
136523044	136523067	9	-	27260156	CORL105	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	0.23530581384643262	[298]	[354,325,510,470]	4	hSpCas9	negative selection	6528464
136518807	136518830	9	-	27260156	CORL105	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	0.4072319606638275	[467]	[677,702,735,788]	7	hSpCas9	negative selection	6528465
136518750	136518773	9	+	27260156	CORL105	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	0.17852642951738312	[568]	[643,749,709,899]	3	hSpCas9	negative selection	6592720
136544023	136544046	9	+	27260156	CORL105	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.1295699044300449	[1005]	[1117,1239,1511,1312]	2	hSpCas9	negative selection	6592721
136544049	136544072	9	+	27260156	CORL105	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.5752685387540166	[1399]	[2301,2217,2953,2372]	9	hSpCas9	negative selection	6592722
136522993	136523016	9	-	27260156	HS294T	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	0.3831642745455416	[761]	[224,404,403,542]	5	hSpCas9	negative selection	6649714
136523044	136523067	9	-	27260156	HS294T	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.044889619702882966	[298]	[92,118,122,114]	0	hSpCas9	negative selection	6649715
136518807	136518830	9	-	27260156	HS294T	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	0.7843376783131709	[467]	[173,351,342,403]	8	hSpCas9	negative selection	6649716
136518750	136518773	9	+	27260156	HS294T	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	-0.28565299972313024	[568]	[141,228,153,201]	-4	hSpCas9	negative selection	6713971
136544023	136544046	9	+	27260156	HS294T	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	-0.05060062646983288	[1005]	[391,330,371,411]	0	hSpCas9	negative selection	6713972
136544049	136544072	9	+	27260156	HS294T	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.14217224286462904	[1399]	[554,680,523,634]	2	hSpCas9	negative selection	6713973
136522993	136523016	9	-	27260156	HCC44	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.21438810089787502	[761]	[536,406,993,1087]	-4	hSpCas9	negative selection	6770965
136523044	136523067	9	-	27260156	HCC44	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	0.300296315671405	[298]	[344,341,242,696]	5	hSpCas9	negative selection	6770966
136518807	136518830	9	-	27260156	HCC44	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.43897951866365675	[467]	[413,245,516,424]	-6	hSpCas9	negative selection	6770967
136518750	136518773	9	+	27260156	HCC44	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	-0.010777178535201881	[568]	[664,671,595,607]	0	hSpCas9	negative selection	6835222
136544023	136544046	9	+	27260156	HCC44	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.12078573743683285	[1005]	[1258,1137,1448,1147]	2	hSpCas9	negative selection	6835223
136544049	136544072	9	+	27260156	HCC44	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.5114998883565229	[1399]	[2503,2073,2202,2267]	8	hSpCas9	negative selection	6835224
136522993	136523016	9	-	27260156	G402	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.3021956505548036	[761]	[605,1184,682,552]	-4	hSpCas9	negative selection	6892216
136523044	136523067	9	-	27260156	G402	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.3637499677437501	[298]	[375,197,253,311]	-4	hSpCas9	negative selection	6892217
136518807	136518830	9	-	27260156	G402	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.2854223793110256	[467]	[402,729,358,389]	-4	hSpCas9	negative selection	6892218
136518750	136518773	9	+	27260156	G402	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	0.3574183513020931	[568]	[1013,993,902,677]	4	hSpCas9	negative selection	6956473
136544023	136544046	9	+	27260156	G402	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.21244740691812836	[1005]	[1778,1514,1183,1269]	2	hSpCas9	negative selection	6956474
136544049	136544072	9	+	27260156	G402	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.7485414091267202	[1399]	[3581,2593,2172,3190]	8	hSpCas9	negative selection	6956475
136522993	136523016	9	-	27260156	L33	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.17094658218505954	[761]	[590,259,497,691]	-4	hSpCas9	negative selection	7013467
136523044	136523067	9	-	27260156	L33	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	0.2651251647301119	[298]	[344,144,239,356]	5	hSpCas9	negative selection	7013468
136518807	136518830	9	-	27260156	L33	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.4669922179256782	[467]	[375,123,203,349]	-8	hSpCas9	negative selection	7013469
136518750	136518773	9	+	27260156	L33	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	-0.13864176990516267	[568]	[504,248,392,331]	-3	hSpCas9	negative selection	7077724
136544023	136544046	9	+	27260156	L33	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.018003877805114588	[1005]	[1142,414,652,877]	0	hSpCas9	negative selection	7077725
136544049	136544072	9	+	27260156	L33	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.30727664798933163	[1399]	[1819,634,1207,1636]	6	hSpCas9	negative selection	7077726
136522993	136523016	9	-	27260156	K562	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.9303567997436726	[761]	[456,218,434,312]	-8	hSpCas9	negative selection	7134718
136523044	136523067	9	-	27260156	K562	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.6938886075409536	[298]	[235,171,129,127]	-7	hSpCas9	negative selection	7134719
136518807	136518830	9	-	27260156	K562	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.28117705228216805	[467]	[93,258,268,678]	-3	hSpCas9	negative selection	7134720
136518750	136518773	9	+	27260156	K562	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	0.23844971019434402	[568]	[594,630,559,595]	3	hSpCas9	negative selection	7198975
136544023	136544046	9	+	27260156	K562	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.12639744527113672	[1005]	[1094,938,696,1149]	1	hSpCas9	negative selection	7198976
136544049	136544072	9	+	27260156	K562	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.592736914309197	[1399]	[2111,1708,1731,1936]	7	hSpCas9	negative selection	7198977
136522993	136523016	9	-	27260156	HT29	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.08144900136194833	[761]	[798,962,930,811]	-2	hSpCas9	negative selection	7255969
136523044	136523067	9	-	27260156	HT29	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.12102376093928857	[298]	[278,416,411,240]	-2	hSpCas9	negative selection	7255970
136518807	136518830	9	-	27260156	HT29	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.1073152354547538	[467]	[548,572,516,480]	-2	hSpCas9	negative selection	7255971
136518750	136518773	9	+	27260156	HT29	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	-0.1319059315278524	[568]	[792,514,620,597]	-3	hSpCas9	negative selection	7320226
136544023	136544046	9	+	27260156	HT29	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.05003267127695388	[1005]	[1319,1403,1161,1193]	0	hSpCas9	negative selection	7320227
136544049	136544072	9	+	27260156	HT29	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.6679471783183983	[1399]	[3079,3041,2737,2072]	9	hSpCas9	negative selection	7320228
136522993	136523016	9	-	27260156	MHHES1	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.14966601011073621	[761]	[961,555,839,729]	-3	hSpCas9	negative selection	7377220
136523044	136523067	9	-	27260156	MHHES1	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.3004308454830912	[298]	[350,342,226,199]	-5	hSpCas9	negative selection	7377221
136518807	136518830	9	-	27260156	MHHES1	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.13375511575698038	[467]	[521,674,454,320]	-3	hSpCas9	negative selection	7377222
136518750	136518773	9	+	27260156	MHHES1	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	0.010335013731670728	[568]	[645,682,720,544]	0	hSpCas9	negative selection	7441477
136544023	136544046	9	+	27260156	MHHES1	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	-0.06837434245468765	[1005]	[1040,1303,975,1009]	-1	hSpCas9	negative selection	7441478
136544049	136544072	9	+	27260156	MHHES1	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.43849078470999436	[1399]	[2689,2316,2289,1449]	7	hSpCas9	negative selection	7441479
136522993	136523016	9	-	27260156	MEWO	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.031900186320834356	[761]	[765,507,831]	0	hSpCas9	negative selection	7498471
136523044	136523067	9	-	27260156	MEWO	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.19685020574427148	[298]	[264,277,192]	-4	hSpCas9	negative selection	7498472
136518807	136518830	9	-	27260156	MEWO	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.3881423033894594	[467]	[267,275,446]	-7	hSpCas9	negative selection	7498473
136518750	136518773	9	+	27260156	MEWO	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	0.08219292073967543	[568]	[662,516,529]	1	hSpCas9	negative selection	7562728
136544023	136544046	9	+	27260156	MEWO	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.03396495373680031	[1005]	[1182,774,975]	0	hSpCas9	negative selection	7562729
136544049	136544072	9	+	27260156	MEWO	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.49772580820147305	[1399]	[1923,1898,1738]	8	hSpCas9	negative selection	7562730
136522993	136523016	9	-	27260156	LNCAPCLONEFGC	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.24934141500368212	[761]	[596,533,693,516]	-4	hSpCas9	negative selection	7619722
136523044	136523067	9	-	27260156	LNCAPCLONEFGC	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.1082743219024912	[298]	[175,284,337,217]	-2	hSpCas9	negative selection	7619723
136518807	136518830	9	-	27260156	LNCAPCLONEFGC	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.12253238116925844	[467]	[487,363,367,333]	-2	hSpCas9	negative selection	7619724
136518750	136518773	9	+	27260156	LNCAPCLONEFGC	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	0.23084109781153195	[568]	[510,612,770,549]	3	hSpCas9	negative selection	7683979
136544023	136544046	9	+	27260156	LNCAPCLONEFGC	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.30032033505609346	[1005]	[1121,1149,1235,994]	5	hSpCas9	negative selection	7683980
136544049	136544072	9	+	27260156	LNCAPCLONEFGC	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.6513071526430021	[1399]	[1888,2040,2229,1839]	8	hSpCas9	negative selection	7683981
136522993	136523016	9	-	27260156	PANC0327	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	0.19691949261707864	[761]	[836,856,799,603]	3	hSpCas9	negative selection	7740973
136523044	136523067	9	-	27260156	PANC0327	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	0.6780842328312552	[298]	[469,255,357,640]	8	hSpCas9	negative selection	7740974
136518807	136518830	9	-	27260156	PANC0327	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	0.08543773998283834	[467]	[477,645,447,168]	1	hSpCas9	negative selection	7740975
136518750	136518773	9	+	27260156	PANC0327	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	-0.11271454736318492	[568]	[288,462,664,438]	-2	hSpCas9	negative selection	7805230
136544023	136544046	9	+	27260156	PANC0327	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.3501067370412132	[1005]	[1370,1218,1190,783]	5	hSpCas9	negative selection	7805231
136544049	136544072	9	+	27260156	PANC0327	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.44484209324942037	[1399]	[2067,1353,1643,1778]	6	hSpCas9	negative selection	7805232
136522993	136523016	9	-	27260156	NCIH2009	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	0.19612847366298014	[761]	[1127,1208,1301]	2	hSpCas9	negative selection	7862224
136523044	136523067	9	-	27260156	NCIH2009	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	0.03935522552177162	[298]	[402,317,562]	0	hSpCas9	negative selection	7862225
136518807	136518830	9	-	27260156	NCIH2009	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	0.34343669797707804	[467]	[1138,971,434]	5	hSpCas9	negative selection	7862226
136518750	136518773	9	+	27260156	NCIH2009	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	0.15149234979935222	[568]	[1367,737,639]	2	hSpCas9	negative selection	7926481
136544023	136544046	9	+	27260156	NCIH2009	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.5579511892831059	[1005]	[2628,1944,1742]	7	hSpCas9	negative selection	7926482
136544049	136544072	9	+	27260156	NCIH2009	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.6487060654606618	[1399]	[3583,2668,3050]	8	hSpCas9	negative selection	7926483
136522993	136523016	9	-	27260156	NCIH1373	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.271882578650911	[761]	[936,491,890,144]	-3	hSpCas9	negative selection	7983475
136523044	136523067	9	-	27260156	NCIH1373	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	0.011203979119639551	[298]	[367,219,395,100]	0	hSpCas9	negative selection	7983476
136518807	136518830	9	-	27260156	NCIH1373	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	0.2747858456136455	[467]	[873,312,830,152]	2	hSpCas9	negative selection	7983477
136518750	136518773	9	+	27260156	NCIH1373	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	0.02346953859506251	[568]	[1115,325,570,180]	0	hSpCas9	negative selection	8047732
136544023	136544046	9	+	27260156	NCIH1373	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.8334948127912316	[1005]	[1734,1675,1638,798]	8	hSpCas9	negative selection	8047733
136544049	136544072	9	+	27260156	NCIH1373	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	1.0606637232543277	[1399]	[3890,2425,3476,913]	9	hSpCas9	negative selection	8047734
136522993	136523016	9	-	27260156	PATU8902	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.46085694445747527	[761]	[893,948,726,483]	-4	hSpCas9	negative selection	8104726
136523044	136523067	9	-	27260156	PATU8902	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.048170012598321654	[298]	[606,607,196,225]	0	hSpCas9	negative selection	8104727
136518807	136518830	9	-	27260156	PATU8902	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.5304382555060924	[467]	[372,472,269,771]	-5	hSpCas9	negative selection	8104728
136518750	136518773	9	+	27260156	PATU8902	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	0.15327869540894412	[568]	[1321,726,458,1144]	1	hSpCas9	negative selection	8168983
136544023	136544046	9	+	27260156	PATU8902	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.6132371021989842	[1005]	[2695,2131,1936,1794]	6	hSpCas9	negative selection	8168984
136544049	136544072	9	+	27260156	PATU8902	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.8026150377056067	[1399]	[3152,3026,3554,3857]	8	hSpCas9	negative selection	8168985
136522993	136523016	9	-	27260156	PANC1	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.14384031969625488	[761]	[532,827,539,519]	-2	hSpCas9	negative selection	8225977
136523044	136523067	9	-	27260156	PANC1	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	0.07718097231697696	[298]	[159,334,340,260]	1	hSpCas9	negative selection	8225978
136518807	136518830	9	-	27260156	PANC1	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.21537574489715358	[467]	[326,536,302,264]	-3	hSpCas9	negative selection	8225979
136518750	136518773	9	+	27260156	PANC1	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	-0.025693365433509863	[568]	[366,806,427,393]	0	hSpCas9	negative selection	8290234
136544023	136544046	9	+	27260156	PANC1	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.0966274372325302	[1005]	[906,825,1109,833]	1	hSpCas9	negative selection	8290235
136544049	136544072	9	+	27260156	PANC1	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.7499414785353171	[1399]	[2299,2756,1799,1438]	9	hSpCas9	negative selection	8290236
136522993	136523016	9	-	27260156	PANC0813	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.16233967394739368	[761]	[1019,711,860,634]	-3	hSpCas9	negative selection	8347228
136523044	136523067	9	-	27260156	PANC0813	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	0.09805493317173897	[298]	[409,409,380,308]	1	hSpCas9	negative selection	8347229
136518807	136518830	9	-	27260156	PANC0813	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	0.3796759879610303	[467]	[674,775,983,437]	6	hSpCas9	negative selection	8347230
136518750	136518773	9	+	27260156	PANC0813	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	0.2399202029772628	[568]	[668,869,664,931]	4	hSpCas9	negative selection	8411485
136544023	136544046	9	+	27260156	PANC0813	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.29502306090454566	[1005]	[1549,1601,1548,1123]	5	hSpCas9	negative selection	8411486
136544049	136544072	9	+	27260156	PANC0813	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.29383695690960865	[1399]	[2221,2195,1562,2091]	5	hSpCas9	negative selection	8411487
136522993	136523016	9	-	27260156	RDES	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.3173150108639417	[761]	[775,574,712,723]	-5	hSpCas9	negative selection	8468479
136523044	136523067	9	-	27260156	RDES	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.025331493189371668	[298]	[239,380,452,279]	0	hSpCas9	negative selection	8468480
136518807	136518830	9	-	27260156	RDES	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.38492697291633876	[467]	[411,294,435,520]	-6	hSpCas9	negative selection	8468481
136518750	136518773	9	+	27260156	RDES	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	0.22068751026133399	[568]	[528,724,901,962]	3	hSpCas9	negative selection	8532736
136544023	136544046	9	+	27260156	RDES	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.31884174700553025	[1005]	[1403,1388,1376,1585]	5	hSpCas9	negative selection	8532737
136544049	136544072	9	+	27260156	RDES	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.590301146882559	[1399]	[1952,2254,2782,2824]	8	hSpCas9	negative selection	8532738
136522993	136523016	9	-	27260156	PC3	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.23733288219319532	[761]	[507,563,827,739]	-5	hSpCas9	negative selection	8589730
136523044	136523067	9	-	27260156	PC3	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.12464758297335332	[298]	[197,290,489,196]	-3	hSpCas9	negative selection	8589731
136518807	136518830	9	-	27260156	PC3	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	0.04074175488871803	[467]	[507,437,625,310]	0	hSpCas9	negative selection	8589732
136518750	136518773	9	+	27260156	PC3	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	-0.1801001276637386	[568]	[294,508,659,649]	-4	hSpCas9	negative selection	8653987
136544023	136544046	9	+	27260156	PC3	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	-0.08380887511979873	[1005]	[570,795,1566,1187]	-2	hSpCas9	negative selection	8653988
136544049	136544072	9	+	27260156	PC3	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.3529756611233268	[1399]	[1059,1861,2980,1840]	7	hSpCas9	negative selection	8653989
136522993	136523016	9	-	27260156	PATU8988T	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	0.039635526779235764	[761]	[822,681,583,948]	0	hSpCas9	negative selection	8710981
136523044	136523067	9	-	27260156	PATU8988T	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.3466202008982149	[298]	[110,269,310,218]	-5	hSpCas9	negative selection	8710982
136518807	136518830	9	-	27260156	PATU8988T	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.430075968537032	[467]	[288,451,367,235]	-6	hSpCas9	negative selection	8710983
136518750	136518773	9	+	27260156	PATU8988T	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	0.11499807395093908	[568]	[669,382,732,571]	2	hSpCas9	negative selection	8775238
136544023	136544046	9	+	27260156	PATU8988T	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.014322141322364201	[1005]	[1001,984,1091,834]	0	hSpCas9	negative selection	8775239
136544049	136544072	9	+	27260156	PATU8988T	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.5536875102283345	[1399]	[1624,2528,2061,1757]	8	hSpCas9	negative selection	8775240
136522993	136523016	9	-	27260156	T47D	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.3178738361887036	[761]	[698,665,701,787]	-6	hSpCas9	negative selection	8832232
136523044	136523067	9	-	27260156	T47D	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.25293801414985795	[298]	[247,277,295,349]	-5	hSpCas9	negative selection	8832233
136518807	136518830	9	-	27260156	T47D	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.2526693969173129	[467]	[420,505,465,431]	-5	hSpCas9	negative selection	8832234
136518750	136518773	9	+	27260156	T47D	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	0.02720540427397844	[568]	[679,748,686,575]	0	hSpCas9	negative selection	8896489
136544023	136544046	9	+	27260156	T47D	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.03242592773738551	[1005]	[1303,1167,1112,1213]	0	hSpCas9	negative selection	8896490
136544049	136544072	9	+	27260156	T47D	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.38544348271498086	[1399]	[2324,1875,2128,2216]	7	hSpCas9	negative selection	8896491
136522993	136523016	9	-	27260156	SU8686	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.17605603051871022	[761]	[587,586,705,836]	-3	hSpCas9	negative selection	8953483
136523044	136523067	9	-	27260156	SU8686	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	0.22347432380938426	[298]	[311,270,363,468]	4	hSpCas9	negative selection	8953484
136518807	136518830	9	-	27260156	SU8686	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	0.2915038198687592	[467]	[457,540,593,714]	5	hSpCas9	negative selection	8953485
136518750	136518773	9	+	27260156	SU8686	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	0.09789324680028794	[568]	[560,471,682,740]	1	hSpCas9	negative selection	9017740
136544023	136544046	9	+	27260156	SU8686	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.24996329068878165	[1005]	[1028,1078,1465,1203]	4	hSpCas9	negative selection	9017741
136544049	136544072	9	+	27260156	SU8686	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.5250311881112057	[1399]	[1746,1903,2019,2411]	8	hSpCas9	negative selection	9017742
136522993	136523016	9	-	27260156	SKES1	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.1838579452833583	[761]	[872,848,436,574]	-4	hSpCas9	negative selection	9074734
136523044	136523067	9	-	27260156	SKES1	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.31415452772133234	[298]	[202,352,144,262]	-6	hSpCas9	negative selection	9074735
136518807	136518830	9	-	27260156	SKES1	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.33854014756588324	[467]	[460,471,319,258]	-6	hSpCas9	negative selection	9074736
136518750	136518773	9	+	27260156	SKES1	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	-0.054064338730810374	[568]	[716,517,546,432]	-1	hSpCas9	negative selection	9138991
136544023	136544046	9	+	27260156	SKES1	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.14839412030285604	[1005]	[1162,1151,917,1206]	3	hSpCas9	negative selection	9138992
136544049	136544072	9	+	27260156	SKES1	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.30942388374379703	[1399]	[1500,2098,1614,1705]	6	hSpCas9	negative selection	9138993
136522993	136523016	9	-	27260156	TOV112D	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.27086432012034123	[761]	[488,1020,555,548]	-5	hSpCas9	negative selection	9195985
136523044	136523067	9	-	27260156	TOV112D	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.10355083390943143	[298]	[253,242,343,262]	-2	hSpCas9	negative selection	9195986
136518807	136518830	9	-	27260156	TOV112D	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	0.17725346034187547	[467]	[289,636,622,573]	3	hSpCas9	negative selection	9195987
136518750	136518773	9	+	27260156	TOV112D	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	0.195815863380483	[568]	[925,903,404,464]	4	hSpCas9	negative selection	9260242
136544023	136544046	9	+	27260156	TOV112D	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.20366824639328907	[1005]	[903,1786,955,1125]	4	hSpCas9	negative selection	9260243
136544049	136544072	9	+	27260156	TOV112D	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.3275556791832066	[1399]	[1825,2099,1775,1431]	6	hSpCas9	negative selection	9260244
136522993	136523016	9	-	27260156	TC71	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.2773472634852299	[761]	[693,566,683,754]	-6	hSpCas9	negative selection	9317236
136523044	136523067	9	-	27260156	TC71	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.22908413246639725	[298]	[264,240,289,298]	-6	hSpCas9	negative selection	9317237
136518807	136518830	9	-	27260156	TC71	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.13183753499765105	[467]	[487,409,475,455]	-3	hSpCas9	negative selection	9317238
136518750	136518773	9	+	27260156	TC71	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	0.06286479939595474	[568]	[767,535,589,653]	1	hSpCas9	negative selection	9381493
136544023	136544046	9	+	27260156	TC71	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.0687003118717544	[1005]	[940,1322,1032,1240]	1	hSpCas9	negative selection	9381494
136544049	136544072	9	+	27260156	TC71	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.3935060162216273	[1399]	[1914,2092,1723,2174]	8	hSpCas9	negative selection	9381495
136522993	136523016	9	-	27260156	TC32	viability	GGCACCTGCCACAACGAGGTCGG	NOTCH1	ENSG00000148400	-0.534500444329344	[761]	[430,351,629,628]	-8	hSpCas9	negative selection	9438487
136523044	136523067	9	-	27260156	TC32	viability	CGGCAGGATGTCAACGAGTGTGG	NOTCH1	ENSG00000148400	-0.27221294562413256	[298]	[193,60,416,356]	-5	hSpCas9	negative selection	9438488
136518807	136518830	9	-	27260156	TC32	viability	TGCAGGTCAGTACTGTACCGAGG	NOTCH1	ENSG00000148400	-0.3453793977377069	[467]	[432,156,480,379]	-6	hSpCas9	negative selection	9438489
136518750	136518773	9	+	27260156	TC32	viability	TGTGGCAGGTCCCGCCGTTCTGG	NOTCH1	ENSG00000148400	0.15094103233475165	[568]	[419,599,731,630]	2	hSpCas9	negative selection	9502744
136544023	136544046	9	+	27260156	TC32	viability	CACGCAGGCCTCCGTGCCATTGG	NOTCH1	ENSG00000148400	0.24656922092435352	[1005]	[1192,761,1409,1237]	4	hSpCas9	negative selection	9502745
136544049	136544072	9	+	27260156	TC32	viability	CTTCACACTTCCCGCCATTCAGG	NOTCH1	ENSG00000148400	0.48550635100740736	[1399]	[1752,1468,2414,1871]	8	hSpCas9	negative selection	9502746
136518274	136518297	9	+	27869803	HPAFII	viability after 27 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	0.5588834329419843	[569]	[183,655,NaN]	4	hSpCas9	negative selection	9605220
136518760	136518783	9	-	27869803	HPAFII	viability after 27 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	-1.44612129023571	[97]	[13,22,NaN]	-7	hSpCas9	negative selection	9605221
136519499	136519522	9	-	27869803	HPAFII	viability after 27 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	0.41887694629036376	[308]	[196,233,NaN]	3	hSpCas9	negative selection	9605222
136523017	136523040	9	-	27869803	HPAFII	viability after 27 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	0.5619852217733328	[185]	[157,132,NaN]	4	hSpCas9	negative selection	9605223
136523901	136523924	9	+	27869803	HPAFII	viability after 27 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	-0.13199322075109382	[208]	[24,162,NaN]	-1	hSpCas9	negative selection	9605224
136544039	136544062	9	-	27869803	HPAFII	viability after 27 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	0.24400790486676893	[85]	[40,63,NaN]	2	hSpCas9	negative selection	9605225
136518274	136518297	9	+	27869803	HPAFII	viability after 15 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	0.12364068995968158	[569]	[614,699,NaN]	1	hSpCas9	negative selection	9687669
136518760	136518783	9	-	27869803	HPAFII	viability after 15 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	-0.12815658730231339	[97]	[141,67,NaN]	-1	hSpCas9	negative selection	9687670
136519499	136519522	9	-	27869803	HPAFII	viability after 15 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	-0.29631064763415843	[308]	[439,164,NaN]	-3	hSpCas9	negative selection	9687671
136523017	136523040	9	-	27869803	HPAFII	viability after 15 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	0.9667960936064398	[185]	[423,369,NaN]	9	hSpCas9	negative selection	9687672
136523901	136523924	9	+	27869803	HPAFII	viability after 15 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	0.3423484063539925	[208]	[203,334,NaN]	4	hSpCas9	negative selection	9687673
136544039	136544062	9	-	27869803	HPAFII	viability after 15 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	-0.5529591149563495	[85]	[62,62,NaN]	-5	hSpCas9	negative selection	9687674
136518274	136518297	9	+	27869803	ASPC1	viability after 36 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	0.12837115172382663	[1140]	[541,491,310]	1	hSpCas9	negative selection	9770118
136518760	136518783	9	-	27869803	ASPC1	viability after 36 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	-0.08747342611813624	[218]	[137,101,0]	-1	hSpCas9	negative selection	9770119
136519499	136519522	9	-	27869803	ASPC1	viability after 36 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	-0.2472398351479424	[973]	[314,388,181]	-3	hSpCas9	negative selection	9770120
136523017	136523040	9	-	27869803	ASPC1	viability after 36 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	0.0009777547211868298	[658]	[133,96,400]	0	hSpCas9	negative selection	9770121
136523901	136523924	9	+	27869803	ASPC1	viability after 36 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	-0.2621911063152761	[362]	[141,174,23]	-3	hSpCas9	negative selection	9770122
136544039	136544062	9	-	27869803	ASPC1	viability after 36 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	-0.8557375693685061	[294]	[131,0,47]	-7	hSpCas9	negative selection	9770123
136518274	136518297	9	+	27869803	PATU8988S	viability after 35 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	-0.17104826200181078	[1181]	[346,498,NaN]	-2	hSpCas9	negative selection	9852567
136518760	136518783	9	-	27869803	PATU8988S	viability after 35 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	0.9558514182890918	[234]	[221,144,NaN]	8	hSpCas9	negative selection	9852568
136519499	136519522	9	-	27869803	PATU8988S	viability after 35 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	0.025023650513539886	[604]	[215,279,NaN]	0	hSpCas9	negative selection	9852569
136523017	136523040	9	-	27869803	PATU8988S	viability after 35 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	-0.5830222575949371	[529]	[140,143,NaN]	-5	hSpCas9	negative selection	9852570
136523901	136523924	9	+	27869803	PATU8988S	viability after 35 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	-0.30784200334993683	[486]	[136,179,NaN]	-3	hSpCas9	negative selection	9852571
136544039	136544062	9	-	27869803	PATU8988S	viability after 35 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	-1.3852958079589348	[252]	[41,35,NaN]	-8	hSpCas9	negative selection	9852572
136518274	136518297	9	+	27869803	PATU8988S	viability after 31 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	0.17239052640336494	[1181]	[414,678,NaN]	2	hSpCas9	negative selection	9935016
136518760	136518783	9	-	27869803	PATU8988S	viability after 31 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	0.4952115248399137	[234]	[128,135,NaN]	6	hSpCas9	negative selection	9935017
136519499	136519522	9	-	27869803	PATU8988S	viability after 31 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	-0.3764322408079619	[604]	[169,205,NaN]	-4	hSpCas9	negative selection	9935018
136523017	136523040	9	-	27869803	PATU8988S	viability after 31 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	-0.5487160540072297	[529]	[114,181,NaN]	-6	hSpCas9	negative selection	9935019
136523901	136523924	9	+	27869803	PATU8988S	viability after 31 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	-0.664045390071954	[486]	[89,163,NaN]	-6	hSpCas9	negative selection	9935020
136544039	136544062	9	-	27869803	PATU8988S	viability after 31 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	-1.9164970906642969	[252]	[42,5,NaN]	-9	hSpCas9	negative selection	9935021
136518274	136518297	9	+	27869803	HPAFII	viability after 35 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	0.9538524997457303	[569]	[224,934,NaN]	6	hSpCas9	negative selection	10017465
136518760	136518783	9	-	27869803	HPAFII	viability after 35 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	-1.3665014130991149	[97]	[30,5,NaN]	-6	hSpCas9	negative selection	10017466
136519499	136519522	9	-	27869803	HPAFII	viability after 35 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	0.27949038481554267	[308]	[163,218,NaN]	1	hSpCas9	negative selection	10017467
136523017	136523040	9	-	27869803	HPAFII	viability after 35 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	0.5969272792745632	[185]	[156,125,NaN]	4	hSpCas9	negative selection	10017468
136523901	136523924	9	+	27869803	HPAFII	viability after 35 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	-1.4381148564620139	[208]	[15,64,NaN]	-6	hSpCas9	negative selection	10017469
136544039	136544062	9	-	27869803	HPAFII	viability after 35 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	-0.07264488695038218	[85]	[15,69,NaN]	0	hSpCas9	negative selection	10017470
136518274	136518297	9	+	27869803	HPAFII	viability after 31 days	TTGAGGTGGCACAGCAGACCTGG	NOTCH1	ENSG00000148400	0.6573861010900723	[569]	[203,831,NaN]	5	hSpCas9	negative selection	10099914
136518760	136518783	9	-	27869803	HPAFII	viability after 31 days	CAAATGCCTGCCAGAACGGCGGG	NOTCH1	ENSG00000148400	-2.503353897140185	[97]	[2,16,NaN]	-8	hSpCas9	negative selection	10099915
136519499	136519522	9	-	27869803	HPAFII	viability after 31 days	GGAAACAACTGCAAGAACGGGGG	NOTCH1	ENSG00000148400	-0.05346223692641017	[308]	[135,200,NaN]	0	hSpCas9	negative selection	10099916
136523017	136523040	9	-	27869803	HPAFII	viability after 31 days	AAGCCCGGGCTTTGCCGCCACGG	NOTCH1	ENSG00000148400	0.216902969388823	[185]	[161,76,NaN]	1	hSpCas9	negative selection	10099917
136523901	136523924	9	+	27869803	HPAFII	viability after 31 days	TGTCCCGGCGTTCTTGCAGGGGG	NOTCH1	ENSG00000148400	-0.3750532691271573	[208]	[10,176,NaN]	-3	hSpCas9	negative selection	10099918
136544039	136544062	9	-	27869803	HPAFII	viability after 31 days	GGGAAGTGTGAAGCGGCCAATGG	NOTCH1	ENSG00000148400	-0.32959081569633897	[85]	[13,64,NaN]	-2	hSpCas9	negative selection	10099919
136506532	136506555	9	+	28162770	P31FUJ	viability	GGCACTTGCAGATGAACCCGCGG	NOTCH1	ENSG00000148400	0.8313281330053369	[197]	[413]	8	hSpCas9	negative selection	10201463
136510727	136510750	9	-	28162770	P31FUJ	viability	GCATCCTGCCAGAACACCCACGG	NOTCH1	ENSG00000148400	0.14847131364873767	[280]	[365]	1	hSpCas9	negative selection	10201464
136505693	136505716	9	-	28162770	P31FUJ	viability	GCAACCCCTGCTACAACCAGGGG	NOTCH1	ENSG00000148400	0.3154017462966596	[423]	[619]	3	hSpCas9	negative selection	10201465
136544060	136544083	9	-	28162770	P31FUJ	viability	GGTGAGACCTGCCTGAATGGCGG	NOTCH1	ENSG00000148400	-0.4892937643814006	[527]	[441]	-4	hSpCas9	negative selection	10201466
136544031	136544054	9	-	28162770	P31FUJ	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	0.2558581580076452	[190]	[267]	2	hSpCas9	negative selection	10201467
136523971	136523994	9	-	28162770	P31FUJ	viability	ACATCTGCCAACAGCTGTGGCGG	NOTCH1	ENSG00000148400	0.05997954481346729	[159]	[195]	0	hSpCas9	negative selection	10201468
136518761	136518784	9	-	28162770	P31FUJ	viability	CCAAATGCCTGCCAGAACGGCGG	NOTCH1	ENSG00000148400	0.3952290181986635	[131]	[203]	4	hSpCas9	negative selection	10201469
136518740	136518763	9	-	28162770	P31FUJ	viability	GGGACCTGCCACAACACCCACGG	NOTCH1	ENSG00000148400	-0.8177647051355343	[2]	[1]	-6	hSpCas9	negative selection	10201470
136513447	136513470	9	+	28162770	P31FUJ	viability	GCCGCCGTTGACACAAGGGTTGG	NOTCH1	ENSG00000148400	0.5805142758819422	[275]	[484]	6	hSpCas9	negative selection	10201471
136513076	136513099	9	+	28162770	P31FUJ	viability	GCCCTGGTTCAGACATGGGTTGG	NOTCH1	ENSG00000148400	0.1760033411529507	[173]	[230]	1	hSpCas9	negative selection	10201472
136506532	136506555	9	+	28162770	TF1	viability	GGCACTTGCAGATGAACCCGCGG	NOTCH1	ENSG00000148400	NaN	[NaN]	[148]	1	hSpCas9	negative selection	10370829
136510727	136510750	9	-	28162770	TF1	viability	GCATCCTGCCAGAACACCCACGG	NOTCH1	ENSG00000148400	NaN	[NaN]	[464]	1	hSpCas9	negative selection	10370830
136505693	136505716	9	-	28162770	TF1	viability	GCAACCCCTGCTACAACCAGGGG	NOTCH1	ENSG00000148400	NaN	[NaN]	[330]	1	hSpCas9	negative selection	10370831
136544060	136544083	9	-	28162770	TF1	viability	GGTGAGACCTGCCTGAATGGCGG	NOTCH1	ENSG00000148400	NaN	[NaN]	[275]	1	hSpCas9	negative selection	10370832
136544031	136544054	9	-	28162770	TF1	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	NaN	[NaN]	[153]	1	hSpCas9	negative selection	10370833
136523971	136523994	9	-	28162770	TF1	viability	ACATCTGCCAACAGCTGTGGCGG	NOTCH1	ENSG00000148400	NaN	[NaN]	[188]	1	hSpCas9	negative selection	10370834
136518761	136518784	9	-	28162770	TF1	viability	CCAAATGCCTGCCAGAACGGCGG	NOTCH1	ENSG00000148400	NaN	[NaN]	[184]	1	hSpCas9	negative selection	10370835
136518740	136518763	9	-	28162770	TF1	viability	GGGACCTGCCACAACACCCACGG	NOTCH1	ENSG00000148400	NaN	[NaN]	[5]	1	hSpCas9	negative selection	10370836
136513447	136513470	9	+	28162770	TF1	viability	GCCGCCGTTGACACAAGGGTTGG	NOTCH1	ENSG00000148400	NaN	[NaN]	[327]	1	hSpCas9	negative selection	10370837
136513076	136513099	9	+	28162770	TF1	viability	GCCCTGGTTCAGACATGGGTTGG	NOTCH1	ENSG00000148400	NaN	[NaN]	[116]	1	hSpCas9	negative selection	10370838
136506532	136506555	9	+	28162770	SKM1	viability	GGCACTTGCAGATGAACCCGCGG	NOTCH1	ENSG00000148400	-0.8411105209697102	[75]	[74]	-6	hSpCas9	negative selection	10540195
136510727	136510750	9	-	28162770	SKM1	viability	GCATCCTGCCAGAACACCCACGG	NOTCH1	ENSG00000148400	0.7961276666343499	[42]	[131]	7	hSpCas9	negative selection	10540196
136505693	136505716	9	-	28162770	SKM1	viability	GCAACCCCTGCTACAACCAGGGG	NOTCH1	ENSG00000148400	-0.02363555919165594	[114]	[199]	0	hSpCas9	negative selection	10540197
136544060	136544083	9	-	28162770	SKM1	viability	GGTGAGACCTGCCTGAATGGCGG	NOTCH1	ENSG00000148400	0.4156898596973251	[133]	[315]	4	hSpCas9	negative selection	10540198
136544031	136544054	9	-	28162770	SKM1	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	0.16072031054615887	[41]	[82]	1	hSpCas9	negative selection	10540199
136523971	136523994	9	-	28162770	SKM1	viability	ACATCTGCCAACAGCTGTGGCGG	NOTCH1	ENSG00000148400	0.203089282940825	[56]	[115]	2	hSpCas9	negative selection	10540200
136518761	136518784	9	-	28162770	SKM1	viability	CCAAATGCCTGCCAGAACGGCGG	NOTCH1	ENSG00000148400	0.9073507120343254	[18]	[62]	8	hSpCas9	negative selection	10540201
136518740	136518763	9	-	28162770	SKM1	viability	GGGACCTGCCACAACACCCACGG	NOTCH1	ENSG00000148400	0.17799830197799515	[0]	[1]	1	hSpCas9	negative selection	10540202
136513447	136513470	9	+	28162770	SKM1	viability	GCCGCCGTTGACACAAGGGTTGG	NOTCH1	ENSG00000148400	-0.20691920892451393	[78]	[120]	-2	hSpCas9	negative selection	10540203
136513076	136513099	9	+	28162770	SKM1	viability	GCCCTGGTTCAGACATGGGTTGG	NOTCH1	ENSG00000148400	0.22380199159111935	[30]	[63]	2	hSpCas9	negative selection	10540204
136506532	136506555	9	+	28162770	SKM1	viability	GGCACTTGCAGATGAACCCGCGG	NOTCH1	ENSG00000148400	-0.8411105209697102	[75]	[74]	-6	hSpCas9	negative selection	10709561
136510727	136510750	9	-	28162770	SKM1	viability	GCATCCTGCCAGAACACCCACGG	NOTCH1	ENSG00000148400	0.7961276666343499	[42]	[131]	7	hSpCas9	negative selection	10709562
136505693	136505716	9	-	28162770	SKM1	viability	GCAACCCCTGCTACAACCAGGGG	NOTCH1	ENSG00000148400	-0.02363555919165594	[114]	[199]	0	hSpCas9	negative selection	10709563
136544060	136544083	9	-	28162770	SKM1	viability	GGTGAGACCTGCCTGAATGGCGG	NOTCH1	ENSG00000148400	0.4156898596973251	[133]	[315]	4	hSpCas9	negative selection	10709564
136544031	136544054	9	-	28162770	SKM1	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	0.16072031054615887	[41]	[82]	1	hSpCas9	negative selection	10709565
136523971	136523994	9	-	28162770	SKM1	viability	ACATCTGCCAACAGCTGTGGCGG	NOTCH1	ENSG00000148400	0.203089282940825	[56]	[115]	2	hSpCas9	negative selection	10709566
136518761	136518784	9	-	28162770	SKM1	viability	CCAAATGCCTGCCAGAACGGCGG	NOTCH1	ENSG00000148400	0.9073507120343254	[18]	[62]	8	hSpCas9	negative selection	10709567
136518740	136518763	9	-	28162770	SKM1	viability	GGGACCTGCCACAACACCCACGG	NOTCH1	ENSG00000148400	0.17799830197799515	[0]	[1]	1	hSpCas9	negative selection	10709568
136513447	136513470	9	+	28162770	SKM1	viability	GCCGCCGTTGACACAAGGGTTGG	NOTCH1	ENSG00000148400	-0.20691920892451393	[78]	[120]	-2	hSpCas9	negative selection	10709569
136513076	136513099	9	+	28162770	SKM1	viability	GCCCTGGTTCAGACATGGGTTGG	NOTCH1	ENSG00000148400	0.22380199159111935	[30]	[63]	2	hSpCas9	negative selection	10709570
136506532	136506555	9	+	28162770	PL21	viability	GGCACTTGCAGATGAACCCGCGG	NOTCH1	ENSG00000148400	0.34131567745001445	[213]	[117]	3	hSpCas9	negative selection	10878927
136510727	136510750	9	-	28162770	PL21	viability	GCATCCTGCCAGAACACCCACGG	NOTCH1	ENSG00000148400	0.4477203679166012	[218]	[129]	4	hSpCas9	negative selection	10878928
136505693	136505716	9	-	28162770	PL21	viability	GCAACCCCTGCTACAACCAGGGG	NOTCH1	ENSG00000148400	0.5127298447973464	[371]	[230]	4	hSpCas9	negative selection	10878929
136544060	136544083	9	-	28162770	PL21	viability	GGTGAGACCTGCCTGAATGGCGG	NOTCH1	ENSG00000148400	-1.4672850464238092	[539]	[84]	-7	hSpCas9	negative selection	10878930
136544031	136544054	9	-	28162770	PL21	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	0.8757888573351023	[148]	[118]	7	hSpCas9	negative selection	10878931
136523971	136523994	9	-	28162770	PL21	viability	ACATCTGCCAACAGCTGTGGCGG	NOTCH1	ENSG00000148400	0.6765776584323071	[206]	[143]	6	hSpCas9	negative selection	10878932
136518761	136518784	9	-	28162770	PL21	viability	CCAAATGCCTGCCAGAACGGCGG	NOTCH1	ENSG00000148400	1.0281869317000254	[88]	[78]	8	hSpCas9	negative selection	10878933
136518740	136518763	9	-	28162770	PL21	viability	GGGACCTGCCACAACACCCACGG	NOTCH1	ENSG00000148400	0.20013961448931994	[3]	[1]	1	hSpCas9	negative selection	10878934
136513447	136513470	9	+	28162770	PL21	viability	GCCGCCGTTGACACAAGGGTTGG	NOTCH1	ENSG00000148400	0.25177238290464227	[246]	[127]	2	hSpCas9	negative selection	10878935
136513076	136513099	9	+	28162770	PL21	viability	GCCCTGGTTCAGACATGGGTTGG	NOTCH1	ENSG00000148400	-0.6287484691179254	[134]	[37]	-4	hSpCas9	negative selection	10878936
136506532	136506555	9	+	28162770	P31FUJ	viability	GGCACTTGCAGATGAACCCGCGG	NOTCH1	ENSG00000148400	0.8313281330053369	[197]	[413]	8	hSpCas9	negative selection	11048293
136510727	136510750	9	-	28162770	P31FUJ	viability	GCATCCTGCCAGAACACCCACGG	NOTCH1	ENSG00000148400	0.14847131364873767	[280]	[365]	1	hSpCas9	negative selection	11048294
136505693	136505716	9	-	28162770	P31FUJ	viability	GCAACCCCTGCTACAACCAGGGG	NOTCH1	ENSG00000148400	0.3154017462966596	[423]	[619]	3	hSpCas9	negative selection	11048295
136544060	136544083	9	-	28162770	P31FUJ	viability	GGTGAGACCTGCCTGAATGGCGG	NOTCH1	ENSG00000148400	-0.4892937643814006	[527]	[441]	-4	hSpCas9	negative selection	11048296
136544031	136544054	9	-	28162770	P31FUJ	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	0.2558581580076452	[190]	[267]	2	hSpCas9	negative selection	11048297
136523971	136523994	9	-	28162770	P31FUJ	viability	ACATCTGCCAACAGCTGTGGCGG	NOTCH1	ENSG00000148400	0.05997954481346729	[159]	[195]	0	hSpCas9	negative selection	11048298
136518761	136518784	9	-	28162770	P31FUJ	viability	CCAAATGCCTGCCAGAACGGCGG	NOTCH1	ENSG00000148400	0.3952290181986635	[131]	[203]	4	hSpCas9	negative selection	11048299
136518740	136518763	9	-	28162770	P31FUJ	viability	GGGACCTGCCACAACACCCACGG	NOTCH1	ENSG00000148400	-0.8177647051355343	[2]	[1]	-6	hSpCas9	negative selection	11048300
136513447	136513470	9	+	28162770	P31FUJ	viability	GCCGCCGTTGACACAAGGGTTGG	NOTCH1	ENSG00000148400	0.5805142758819422	[275]	[484]	6	hSpCas9	negative selection	11048301
136513076	136513099	9	+	28162770	P31FUJ	viability	GCCCTGGTTCAGACATGGGTTGG	NOTCH1	ENSG00000148400	0.1760033411529507	[173]	[230]	1	hSpCas9	negative selection	11048302
136506532	136506555	9	+	28162770	OCIAML5	viability	GGCACTTGCAGATGAACCCGCGG	NOTCH1	ENSG00000148400	-1.2146366502487052	[161]	[125]	-6	hSpCas9	negative selection	11217659
136510727	136510750	9	-	28162770	OCIAML5	viability	GCATCCTGCCAGAACACCCACGG	NOTCH1	ENSG00000148400	0.7809902180582041	[117]	[365]	6	hSpCas9	negative selection	11217660
136505693	136505716	9	-	28162770	OCIAML5	viability	GCAACCCCTGCTACAACCAGGGG	NOTCH1	ENSG00000148400	0.4990078696828819	[195]	[499]	4	hSpCas9	negative selection	11217661
136544060	136544083	9	-	28162770	OCIAML5	viability	GGTGAGACCTGCCTGAATGGCGG	NOTCH1	ENSG00000148400	-0.5629817326636517	[310]	[379]	-4	hSpCas9	negative selection	11217662
136544031	136544054	9	-	28162770	OCIAML5	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	-0.07947706696706952	[95]	[163]	0	hSpCas9	negative selection	11217663
136523971	136523994	9	-	28162770	OCIAML5	viability	ACATCTGCCAACAGCTGTGGCGG	NOTCH1	ENSG00000148400	0.10682822580632984	[88]	[172]	0	hSpCas9	negative selection	11217664
136518761	136518784	9	-	28162770	OCIAML5	viability	CCAAATGCCTGCCAGAACGGCGG	NOTCH1	ENSG00000148400	0.22688477053082506	[79]	[168]	2	hSpCas9	negative selection	11217665
136518740	136518763	9	-	28162770	OCIAML5	viability	GGGACCTGCCACAACACCCACGG	NOTCH1	ENSG00000148400	-0.4476763157846617	[33]	[44]	-3	hSpCas9	negative selection	11217666
136513447	136513470	9	+	28162770	OCIAML5	viability	GCCGCCGTTGACACAAGGGTTGG	NOTCH1	ENSG00000148400	-0.15091105263831817	[154]	[251]	-1	hSpCas9	negative selection	11217667
136513076	136513099	9	+	28162770	OCIAML5	viability	GCCCTGGTTCAGACATGGGTTGG	NOTCH1	ENSG00000148400	-1.248725540827986	[103]	[78]	-6	hSpCas9	negative selection	11217668
136506532	136506555	9	+	28162770	EOL1	viability	GGCACTTGCAGATGAACCCGCGG	NOTCH1	ENSG00000148400	0.5550249315440594	[415]	[321]	5	hSpCas9	negative selection	11387025
136510727	136510750	9	-	28162770	EOL1	viability	GCATCCTGCCAGAACACCCACGG	NOTCH1	ENSG00000148400	-0.590809261664755	[262]	[91]	-4	hSpCas9	negative selection	11387026
136505693	136505716	9	-	28162770	EOL1	viability	GCAACCCCTGCTACAACCAGGGG	NOTCH1	ENSG00000148400	-0.36060944516139926	[735]	[301]	-3	hSpCas9	negative selection	11387027
136544060	136544083	9	-	28162770	EOL1	viability	GGTGAGACCTGCCTGAATGGCGG	NOTCH1	ENSG00000148400	-0.36893297664102653	[928]	[378]	-3	hSpCas9	negative selection	11387028
136544031	136544054	9	-	28162770	EOL1	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	-0.008338032570928411	[335]	[175]	0	hSpCas9	negative selection	11387029
136523971	136523994	9	-	28162770	EOL1	viability	ACATCTGCCAACAGCTGTGGCGG	NOTCH1	ENSG00000148400	-0.7154560927085836	[373]	[119]	-5	hSpCas9	negative selection	11387030
136518761	136518784	9	-	28162770	EOL1	viability	CCAAATGCCTGCCAGAACGGCGG	NOTCH1	ENSG00000148400	-0.12754073957791934	[140]	[67]	-1	hSpCas9	negative selection	11387031
136518740	136518763	9	-	28162770	EOL1	viability	GGGACCTGCCACAACACCCACGG	NOTCH1	ENSG00000148400	0.9245477715705341	[3]	[3]	7	hSpCas9	negative selection	11387032
136513447	136513470	9	+	28162770	EOL1	viability	GCCGCCGTTGACACAAGGGTTGG	NOTCH1	ENSG00000148400	0.7594885253000382	[295]	[263]	6	hSpCas9	negative selection	11387033
136513076	136513099	9	+	28162770	EOL1	viability	GCCCTGGTTCAGACATGGGTTGG	NOTCH1	ENSG00000148400	-0.835781815661182	[165]	[48]	-5	hSpCas9	negative selection	11387034
136506532	136506555	9	+	28162770	MOLM13	viability	GGCACTTGCAGATGAACCCGCGG	NOTCH1	ENSG00000148400	-0.013122155137669109	[260]	[186]	0	hSpCas9	negative selection	11556391
136510727	136510750	9	-	28162770	MOLM13	viability	GCATCCTGCCAGAACACCCACGG	NOTCH1	ENSG00000148400	0.3326886436640645	[312]	[284]	2	hSpCas9	negative selection	11556392
136505693	136505716	9	-	28162770	MOLM13	viability	GCAACCCCTGCTACAACCAGGGG	NOTCH1	ENSG00000148400	0.05742461205555904	[629]	[473]	0	hSpCas9	negative selection	11556393
136544060	136544083	9	-	28162770	MOLM13	viability	GGTGAGACCTGCCTGAATGGCGG	NOTCH1	ENSG00000148400	0.26507249854489157	[731]	[635]	2	hSpCas9	negative selection	11556394
136544031	136544054	9	-	28162770	MOLM13	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	-0.30290980769750253	[301]	[176]	-2	hSpCas9	negative selection	11556395
136523971	136523994	9	-	28162770	MOLM13	viability	ACATCTGCCAACAGCTGTGGCGG	NOTCH1	ENSG00000148400	0.9292205330973575	[275]	[379]	7	hSpCas9	negative selection	11556396
136518761	136518784	9	-	28162770	MOLM13	viability	CCAAATGCCTGCCAGAACGGCGG	NOTCH1	ENSG00000148400	-0.15930135456587446	[155]	[100]	-1	hSpCas9	negative selection	11556397
136518740	136518763	9	-	28162770	MOLM13	viability	GGGACCTGCCACAACACCCACGG	NOTCH1	ENSG00000148400	-0.5321106184554205	[11]	[5]	-3	hSpCas9	negative selection	11556398
136513447	136513470	9	+	28162770	MOLM13	viability	GCCGCCGTTGACACAAGGGTTGG	NOTCH1	ENSG00000148400	0.38835061655937203	[260]	[246]	3	hSpCas9	negative selection	11556399
136513076	136513099	9	+	28162770	MOLM13	viability	GCCCTGGTTCAGACATGGGTTGG	NOTCH1	ENSG00000148400	-0.6364472782701569	[128]	[59]	-4	hSpCas9	negative selection	11556400
136506532	136506555	9	+	28162770	HEL	viability	GGCACTTGCAGATGAACCCGCGG	NOTCH1	ENSG00000148400	0.3436206200210806	[250]	[203]	3	hSpCas9	negative selection	11725757
136510727	136510750	9	-	28162770	HEL	viability	GCATCCTGCCAGAACACCCACGG	NOTCH1	ENSG00000148400	-0.09625729739322	[236]	[141]	0	hSpCas9	negative selection	11725758
136505693	136505716	9	-	28162770	HEL	viability	GCAACCCCTGCTACAACCAGGGG	NOTCH1	ENSG00000148400	0.5823891760855251	[536]	[514]	5	hSpCas9	negative selection	11725759
136544060	136544083	9	-	28162770	HEL	viability	GGTGAGACCTGCCTGAATGGCGG	NOTCH1	ENSG00000148400	0.2927468186951183	[570]	[447]	2	hSpCas9	negative selection	11725760
136544031	136544054	9	-	28162770	HEL	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	-0.3700852083572267	[225]	[111]	-3	hSpCas9	negative selection	11725761
136523971	136523994	9	-	28162770	HEL	viability	ACATCTGCCAACAGCTGTGGCGG	NOTCH1	ENSG00000148400	0.35009796408123967	[255]	[208]	3	hSpCas9	negative selection	11725762
136518761	136518784	9	-	28162770	HEL	viability	CCAAATGCCTGCCAGAACGGCGG	NOTCH1	ENSG00000148400	-1.465785624777812	[137]	[31]	-7	hSpCas9	negative selection	11725763
136518740	136518763	9	-	28162770	HEL	viability	GGGACCTGCCACAACACCCACGG	NOTCH1	ENSG00000148400	-0.5271861694419551	[8]	[3]	-4	hSpCas9	negative selection	11725764
136513447	136513470	9	+	28162770	HEL	viability	GCCGCCGTTGACACAAGGGTTGG	NOTCH1	ENSG00000148400	0.01824796709256335	[258]	[167]	0	hSpCas9	negative selection	11725765
136513076	136513099	9	+	28162770	HEL	viability	GCCCTGGTTCAGACATGGGTTGG	NOTCH1	ENSG00000148400	-0.6591515096504604	[142]	[57]	-4	hSpCas9	negative selection	11725766
136506532	136506555	9	+	28162770	MV411	viability	GGCACTTGCAGATGAACCCGCGG	NOTCH1	ENSG00000148400	0.1105866825702726	[220]	[200]	0	hSpCas9	negative selection	11895123
136510727	136510750	9	-	28162770	MV411	viability	GCATCCTGCCAGAACACCCACGG	NOTCH1	ENSG00000148400	1.1437589046811067	[136]	[254]	8	hSpCas9	negative selection	11895124
136505693	136505716	9	-	28162770	MV411	viability	GCAACCCCTGCTACAACCAGGGG	NOTCH1	ENSG00000148400	0.05915034001294872	[424]	[372]	0	hSpCas9	negative selection	11895125
136544060	136544083	9	-	28162770	MV411	viability	GGTGAGACCTGCCTGAATGGCGG	NOTCH1	ENSG00000148400	-1.1664130335456264	[404]	[151]	-6	hSpCas9	negative selection	11895126
136544031	136544054	9	-	28162770	MV411	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	-0.8999041652924118	[205]	[92]	-6	hSpCas9	negative selection	11895127
136523971	136523994	9	-	28162770	MV411	viability	ACATCTGCCAACAGCTGTGGCGG	NOTCH1	ENSG00000148400	0.6582255770602612	[169]	[225]	6	hSpCas9	negative selection	11895128
136518761	136518784	9	-	28162770	MV411	viability	CCAAATGCCTGCCAGAACGGCGG	NOTCH1	ENSG00000148400	0.6373840690987886	[57]	[75]	6	hSpCas9	negative selection	11895129
136518740	136518763	9	-	28162770	MV411	viability	GGGACCTGCCACAACACCCACGG	NOTCH1	ENSG00000148400	-0.48952804338343103	[4]	[2]	-4	hSpCas9	negative selection	11895130
136513447	136513470	9	+	28162770	MV411	viability	GCCGCCGTTGACACAAGGGTTGG	NOTCH1	ENSG00000148400	0.007039341392011178	[214]	[181]	0	hSpCas9	negative selection	11895131
136513076	136513099	9	+	28162770	MV411	viability	GCCCTGGTTCAGACATGGGTTGG	NOTCH1	ENSG00000148400	-0.30510347224600326	[131]	[89]	-2	hSpCas9	negative selection	11895132
136506532	136506555	9	+	28162770	MONOMAC1	viability	GGCACTTGCAGATGAACCCGCGG	NOTCH1	ENSG00000148400	-0.0988564531206503	[141]	[151]	-1	hSpCas9	negative selection	12064489
136510727	136510750	9	-	28162770	MONOMAC1	viability	GCATCCTGCCAGAACACCCACGG	NOTCH1	ENSG00000148400	0.5254291774115375	[119]	[197]	5	hSpCas9	negative selection	12064490
136505693	136505716	9	-	28162770	MONOMAC1	viability	GCAACCCCTGCTACAACCAGGGG	NOTCH1	ENSG00000148400	0.29062845230668755	[275]	[386]	3	hSpCas9	negative selection	12064491
136544060	136544083	9	-	28162770	MONOMAC1	viability	GGTGAGACCTGCCTGAATGGCGG	NOTCH1	ENSG00000148400	-0.017713147614991875	[339]	[384]	0	hSpCas9	negative selection	12064492
136544031	136544054	9	-	28162770	MONOMAC1	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	-0.19703684705955354	[130]	[130]	-2	hSpCas9	negative selection	12064493
136523971	136523994	9	-	28162770	MONOMAC1	viability	ACATCTGCCAACAGCTGTGGCGG	NOTCH1	ENSG00000148400	-0.5101947323191839	[122]	[98]	-4	hSpCas9	negative selection	12064494
136518761	136518784	9	-	28162770	MONOMAC1	viability	CCAAATGCCTGCCAGAACGGCGG	NOTCH1	ENSG00000148400	0.28838998011068817	[79]	[111]	3	hSpCas9	negative selection	12064495
136518740	136518763	9	-	28162770	MONOMAC1	viability	GGGACCTGCCACAACACCCACGG	NOTCH1	ENSG00000148400	-2.5189649419469164	[4]	[0]	-9	hSpCas9	negative selection	12064496
136513447	136513470	9	+	28162770	MONOMAC1	viability	GCCGCCGTTGACACAAGGGTTGG	NOTCH1	ENSG00000148400	0.6165500287095649	[131]	[231]	6	hSpCas9	negative selection	12064497
136513076	136513099	9	+	28162770	MONOMAC1	viability	GCCCTGGTTCAGACATGGGTTGG	NOTCH1	ENSG00000148400	-1.0383391010404956	[85]	[47]	-7	hSpCas9	negative selection	12064498
136506532	136506555	9	+	28162770	OCIAML2	viability	GGCACTTGCAGATGAACCCGCGG	NOTCH1	ENSG00000148400	0.0814680415733683	[36]	[216]	0	hSpCas9	negative selection	12233855
136510727	136510750	9	-	28162770	OCIAML2	viability	GCATCCTGCCAGAACACCCACGG	NOTCH1	ENSG00000148400	0.40887488257127824	[38]	[286]	4	hSpCas9	negative selection	12233856
136505693	136505716	9	-	28162770	OCIAML2	viability	GCAACCCCTGCTACAACCAGGGG	NOTCH1	ENSG00000148400	-0.1028069643841496	[98]	[510]	-1	hSpCas9	negative selection	12233857
136544060	136544083	9	-	28162770	OCIAML2	viability	GGTGAGACCTGCCTGAATGGCGG	NOTCH1	ENSG00000148400	-0.46141129521278257	[77]	[313]	-4	hSpCas9	negative selection	12233858
136544031	136544054	9	-	28162770	OCIAML2	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	0.38735116988541096	[39]	[289]	4	hSpCas9	negative selection	12233859
136523971	136523994	9	-	28162770	OCIAML2	viability	ACATCTGCCAACAGCTGTGGCGG	NOTCH1	ENSG00000148400	0.4135731756584625	[46]	[346]	4	hSpCas9	negative selection	12233860
136518761	136518784	9	-	28162770	OCIAML2	viability	CCAAATGCCTGCCAGAACGGCGG	NOTCH1	ENSG00000148400	-0.1376465418458031	[25]	[130]	-1	hSpCas9	negative selection	12233861
136518740	136518763	9	-	28162770	OCIAML2	viability	GGGACCTGCCACAACACCCACGG	NOTCH1	ENSG00000148400	-0.47062982524216146	[0]	[3]	-4	hSpCas9	negative selection	12233862
136513447	136513470	9	+	28162770	OCIAML2	viability	GCCGCCGTTGACACAAGGGTTGG	NOTCH1	ENSG00000148400	0.5451951419195213	[33]	[274]	5	hSpCas9	negative selection	12233863
136513076	136513099	9	+	28162770	OCIAML2	viability	GCCCTGGTTCAGACATGGGTTGG	NOTCH1	ENSG00000148400	-1.3153515997642502	[21]	[48]	-7	hSpCas9	negative selection	12233864
136506532	136506555	9	+	28162770	OCIAML3	viability	GGCACTTGCAGATGAACCCGCGG	NOTCH1	ENSG00000148400	-0.857042046157957	[65]	[109]	-6	hSpCas9	negative selection	12403221
136510727	136510750	9	-	28162770	OCIAML3	viability	GCATCCTGCCAGAACACCCACGG	NOTCH1	ENSG00000148400	-0.04445047573420566	[54]	[160]	0	hSpCas9	negative selection	12403222
136505693	136505716	9	-	28162770	OCIAML3	viability	GCAACCCCTGCTACAACCAGGGG	NOTCH1	ENSG00000148400	-0.6241276287004988	[120]	[236]	-5	hSpCas9	negative selection	12403223
136544060	136544083	9	-	28162770	OCIAML3	viability	GGTGAGACCTGCCTGAATGGCGG	NOTCH1	ENSG00000148400	-0.19479065852771837	[148]	[392]	-1	hSpCas9	negative selection	12403224
136544031	136544054	9	-	28162770	OCIAML3	viability	TGAAGCGGCCAATGGCACGGAGG	NOTCH1	ENSG00000148400	0.5563550947396314	[65]	[292]	5	hSpCas9	negative selection	12403225
136523971	136523994	9	-	28162770	OCIAML3	viability	ACATCTGCCAACAGCTGTGGCGG	NOTCH1	ENSG00000148400	1.3153469952358365	[38]	[292]	9	hSpCas9	negative selection	12403226
136518761	136518784	9	-	28162770	OCIAML3	viability	CCAAATGCCTGCCAGAACGGCGG	NOTCH1	ENSG00000148400	0.3925718439135152	[26]	[106]	3	hSpCas9	negative selection	12403227
136518740	136518763	9	-	28162770	OCIAML3	viability	GGGACCTGCCACAACACCCACGG	NOTCH1	ENSG00000148400	-1.009045139603007	[1]	[2]	-6	hSpCas9	negative selection	12403228
136513447	136513470	9	+	28162770	OCIAML3	viability	GCCGCCGTTGACACAAGGGTTGG	NOTCH1	ENSG00000148400	0.19954148220841061	[74]	[259]	2	hSpCas9	negative selection	12403229
136513076	136513099	9	+	28162770	OCIAML3	viability	GCCCTGGTTCAGACATGGGTTGG	NOTCH1	ENSG00000148400	-0.04557101562812116	[39]	[116]	0	hSpCas9	negative selection	12403230