Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:4854
• Symbol:NOTCH3
• Description:notch receptor 3

DataSource: http://genomecrispr.dkfz.de/#!/results/NOTCH3

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
15185295	15185318	19	-	26472758	Jiyoye	viability	GGTGGGACATGCAGCAGCGATGG	NOTCH3	ENSG00000074181	-0.1777871192152829	[20]	[13]	-1	hSpCas9	negative selection	110235
15187195	15187218	19	-	26472758	Jiyoye	viability	CACACGCTGCGAGAGCCAGGTGG	NOTCH3	ENSG00000074181	0.3169775725342949	[32]	[30]	2	hSpCas9	negative selection	110236
15200851	15200874	19	+	26472758	Jiyoye	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	0.18478296016942555	[118]	[101]	1	hSpCas9	negative selection	110237
15192438	15192461	19	+	26472758	Jiyoye	viability	GCAGACACCACGGCCAGCACAGG	NOTCH3	ENSG00000074181	0.28284724650367166	[108]	[99]	2	hSpCas9	negative selection	110238
15192393	15192416	19	+	26472758	Jiyoye	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.6617196997051942	[192]	[91]	-5	hSpCas9	negative selection	110239
15192221	15192244	19	+	26472758	Jiyoye	viability	CATCGGGCCCCACTGAGCAGCGG	NOTCH3	ENSG00000074181	0.42628420445357795	[149]	[151]	3	hSpCas9	negative selection	110240
15192145	15192168	19	-	26472758	Jiyoye	viability	GACGTGGATGAGTGCCGGGTGGG	NOTCH3	ENSG00000074181	-0.8476385175229518	[104]	[43]	-5	hSpCas9	negative selection	110241
15192044	15192067	19	-	26472758	Jiyoye	viability	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	0.9990906428687965	[68]	[103]	6	hSpCas9	negative selection	110242
15192029	15192052	19	+	26472758	Jiyoye	viability	AGGGTGCACAGGGCACCGCGGGG	NOTCH3	ENSG00000074181	-0.19006544899371947	[117]	[77]	-1	hSpCas9	negative selection	110243
15187893	15187916	19	+	26472758	Jiyoye	viability	GGCACTCGTAGCCATCGGGCTGG	NOTCH3	ENSG00000074181	-0.7509724521600855	[182]	[81]	-5	hSpCas9	negative selection	110244
15185295	15185318	19	-	26472758	KBM7	viability	GGTGGGACATGCAGCAGCGATGG	NOTCH3	ENSG00000074181	1.2555569160277766	[48,2]	[41,12]	9	hSpCas9	negative selection	301353
15187195	15187218	19	-	26472758	KBM7	viability	CACACGCTGCGAGAGCCAGGTGG	NOTCH3	ENSG00000074181	-1.4250437690781226	[129,118]	[15,26]	-7	hSpCas9	negative selection	301354
15200851	15200874	19	+	26472758	KBM7	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	0.3760838684253034	[661,471]	[355,328]	4	hSpCas9	negative selection	301355
15192438	15192461	19	+	26472758	KBM7	viability	GCAGACACCACGGCCAGCACAGG	NOTCH3	ENSG00000074181	0.25249105899432406	[603,702]	[414,330]	2	hSpCas9	negative selection	301356
15192393	15192416	19	+	26472758	KBM7	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.726390284681283	[299,365]	[216,303]	7	hSpCas9	negative selection	301357
15192221	15192244	19	+	26472758	KBM7	viability	CATCGGGCCCCACTGAGCAGCGG	NOTCH3	ENSG00000074181	0.5868148358628897	[699,380]	[446,304]	6	hSpCas9	negative selection	301358
15192145	15192168	19	-	26472758	KBM7	viability	GACGTGGATGAGTGCCGGGTGGG	NOTCH3	ENSG00000074181	0.3715832901694265	[240,180]	[124,128]	4	hSpCas9	negative selection	301359
15192044	15192067	19	-	26472758	KBM7	viability	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	-0.003410900905795322	[401,288]	[147,170]	0	hSpCas9	negative selection	301360
15192029	15192052	19	+	26472758	KBM7	viability	AGGGTGCACAGGGCACCGCGGGG	NOTCH3	ENSG00000074181	0.4309590242834861	[377,242]	[166,216]	4	hSpCas9	negative selection	301361
15187893	15187916	19	+	26472758	KBM7	viability	GGCACTCGTAGCCATCGGGCTGG	NOTCH3	ENSG00000074181	0.0770094250857861	[564,469]	[330,187]	0	hSpCas9	negative selection	301362
15185295	15185318	19	-	26472758	Raji	viability	GGTGGGACATGCAGCAGCGATGG	NOTCH3	ENSG00000074181	1.1073835353735992	[1]	[0]	8	hSpCas9	negative selection	492471
15187195	15187218	19	-	26472758	Raji	viability	CACACGCTGCGAGAGCCAGGTGG	NOTCH3	ENSG00000074181	0.4069438172325075	[77]	[23]	4	hSpCas9	negative selection	492472
15200851	15200874	19	+	26472758	Raji	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.45333141910087954	[176]	[29]	-4	hSpCas9	negative selection	492473
15192438	15192461	19	+	26472758	Raji	viability	GCAGACACCACGGCCAGCACAGG	NOTCH3	ENSG00000074181	-0.7544191707063812	[188]	[25]	-5	hSpCas9	negative selection	492474
15192393	15192416	19	+	26472758	Raji	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.28720457295841173	[225]	[63]	2	hSpCas9	negative selection	492475
15192221	15192244	19	+	26472758	Raji	viability	CATCGGGCCCCACTGAGCAGCGG	NOTCH3	ENSG00000074181	0.2170080265480977	[303]	[81]	2	hSpCas9	negative selection	492476
15192145	15192168	19	-	26472758	Raji	viability	GACGTGGATGAGTGCCGGGTGGG	NOTCH3	ENSG00000074181	-0.5040511767087478	[164]	[26]	-4	hSpCas9	negative selection	492477
15192044	15192067	19	-	26472758	Raji	viability	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	0.02141031226374673	[241]	[56]	0	hSpCas9	negative selection	492478
15192029	15192052	19	+	26472758	Raji	viability	AGGGTGCACAGGGCACCGCGGGG	NOTCH3	ENSG00000074181	-0.7450592762125426	[129]	[17]	-5	hSpCas9	negative selection	492479
15187893	15187916	19	+	26472758	Raji	viability	GGCACTCGTAGCCATCGGGCTGG	NOTCH3	ENSG00000074181	0.10148293393391522	[244]	[60]	0	hSpCas9	negative selection	492480
15185295	15185318	19	-	26472758	K562	viability	GGTGGGACATGCAGCAGCGATGG	NOTCH3	ENSG00000074181	0.24441872766644668	[33]	[33]	1	hSpCas9	negative selection	683589
15187195	15187218	19	-	26472758	K562	viability	CACACGCTGCGAGAGCCAGGTGG	NOTCH3	ENSG00000074181	-1.9858788917553474	[121]	[25]	-7	hSpCas9	negative selection	683590
15200851	15200874	19	+	26472758	K562	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	0.5728762084982891	[484]	[608]	4	hSpCas9	negative selection	683591
15192438	15192461	19	+	26472758	K562	viability	GCAGACACCACGGCCAGCACAGG	NOTCH3	ENSG00000074181	0.24784963306672037	[419]	[420]	2	hSpCas9	negative selection	683592
15192393	15192416	19	+	26472758	K562	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.7234900597968653	[324]	[452]	6	hSpCas9	negative selection	683593
15192221	15192244	19	+	26472758	K562	viability	CATCGGGCCCCACTGAGCAGCGG	NOTCH3	ENSG00000074181	0.6262893630100913	[428]	[558]	5	hSpCas9	negative selection	683594
15192145	15192168	19	-	26472758	K562	viability	GACGTGGATGAGTGCCGGGTGGG	NOTCH3	ENSG00000074181	0.2788522247303208	[206]	[211]	2	hSpCas9	negative selection	683595
15192044	15192067	19	-	26472758	K562	viability	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	1.1494934702462056	[211]	[396]	8	hSpCas9	negative selection	683596
15192029	15192052	19	+	26472758	K562	viability	AGGGTGCACAGGGCACCGCGGGG	NOTCH3	ENSG00000074181	0.9685030305359206	[134]	[222]	7	hSpCas9	negative selection	683597
15187893	15187916	19	+	26472758	K562	viability	GGCACTCGTAGCCATCGGGCTGG	NOTCH3	ENSG00000074181	-0.13636920965948662	[443]	[340]	-1	hSpCas9	negative selection	683598
15191597	15191620	19	-	26627737	DLD1	viability	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	-0.23548732780775028	[893]	[130,388,203]	-2	hSpCas9	negative selection	803016
15191744	15191767	19	-	26627737	DLD1	viability	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	0.15843210121469165	[1240]	[213,620,466]	1	hSpCas9	negative selection	803017
15192146	15192169	19	-	26627737	DLD1	viability	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	0.0986678099824706	[743]	[265,246,235]	1	hSpCas9	negative selection	803018
15192370	15192393	19	+	26627737	DLD1	viability	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	-0.43552929140809604	[1245]	[166,503,213]	-4	hSpCas9	negative selection	803019
15197551	15197574	19	+	26627737	DLD1	viability	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.5351466507845388	[1243]	[448,788,475]	5	hSpCas9	negative selection	803020
15200801	15200824	19	-	26627737	DLD1	viability	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	0.9671368579288301	[769]	[471,581,376]	8	hSpCas9	negative selection	803021
15191597	15191620	19	-	26627737	GBM cells	viability after 5 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	0.062272205724155705	[366]	[221,188]	1	hSpCas9	negative selection	885331
15191744	15191767	19	-	26627737	GBM cells	viability after 5 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	0.11136349297455506	[623]	[349,372]	1	hSpCas9	negative selection	885332
15192146	15192169	19	-	26627737	GBM cells	viability after 5 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	-0.1437304625228082	[205]	[96,102]	-2	hSpCas9	negative selection	885333
15192370	15192393	19	+	26627737	GBM cells	viability after 5 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	0.08770776994854224	[421]	[236,243]	1	hSpCas9	negative selection	885334
15197551	15197574	19	+	26627737	GBM cells	viability after 5 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.6368282984454408	[607]	[539,473]	8	hSpCas9	negative selection	885335
15200801	15200824	19	-	26627737	GBM cells	viability after 5 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	0.45895212044661304	[252]	[188,183]	7	hSpCas9	negative selection	885336
15191597	15191620	19	-	26627737	GBM cells	viability after 13 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	0.4612730563278922	[366]	[293,257]	6	hSpCas9	negative selection	967646
15191744	15191767	19	-	26627737	GBM cells	viability after 13 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	0.3429188121206017	[623]	[499,371]	4	hSpCas9	negative selection	967647
15192146	15192169	19	-	26627737	GBM cells	viability after 13 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	0.3254159184521724	[205]	[101,170]	4	hSpCas9	negative selection	967648
15192370	15192393	19	+	26627737	GBM cells	viability after 13 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	0.2784560595923644	[421]	[328,235]	3	hSpCas9	negative selection	967649
15197551	15197574	19	+	26627737	GBM cells	viability after 13 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.5573064344350873	[607]	[528,449]	7	hSpCas9	negative selection	967650
15200801	15200824	19	-	26627737	GBM cells	viability after 13 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	0.23239646593059687	[252]	[211,119]	3	hSpCas9	negative selection	967651
15191597	15191620	19	-	26627737	GBM cells	viability after 21 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	0.16372360548369502	[366]	[226,219]	1	hSpCas9	negative selection	1049961
15191744	15191767	19	-	26627737	GBM cells	viability after 21 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	0.6768618150802042	[623]	[542,540]	6	hSpCas9	negative selection	1049962
15192146	15192169	19	-	26627737	GBM cells	viability after 21 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	0.6835361426280004	[205]	[173,184]	7	hSpCas9	negative selection	1049963
15192370	15192393	19	+	26627737	GBM cells	viability after 21 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	-0.08293887003199019	[421]	[240,193]	0	hSpCas9	negative selection	1049964
15197551	15197574	19	+	26627737	GBM cells	viability after 21 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.8672562397449695	[607]	[612,592]	8	hSpCas9	negative selection	1049965
15200801	15200824	19	-	26627737	GBM cells	viability after 21 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	-0.10351187449179029	[252]	[152,104]	-1	hSpCas9	negative selection	1049966
15191597	15191620	19	-	26627737	RPE1	viability after 9 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	0.9452383023239221	[684]	[532,257]	6	hSpCas9	negative selection	1132276
15191744	15191767	19	-	26627737	RPE1	viability after 9 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	0.49457639013725707	[2232]	[894,1100]	3	hSpCas9	negative selection	1132277
15192146	15192169	19	-	26627737	RPE1	viability after 9 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	0.7486551929888359	[982]	[465,582]	5	hSpCas9	negative selection	1132278
15192370	15192393	19	+	26627737	RPE1	viability after 9 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	-0.2698664797174424	[2069]	[471,621]	-2	hSpCas9	negative selection	1132279
15197551	15197574	19	+	26627737	RPE1	viability after 9 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	1.5919827019675479	[1552]	[1659,1214]	8	hSpCas9	negative selection	1132280
15200801	15200824	19	-	26627737	RPE1	viability after 9 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	0.7175740293012515	[1155]	[533,673]	5	hSpCas9	negative selection	1132281
15191597	15191620	19	-	26627737	RPE1	viability after 12 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	1.3009736287987477	[684]	[485,418]	7	hSpCas9	negative selection	1214591
15191744	15191767	19	-	26627737	RPE1	viability after 12 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	0.821736735830561	[2232]	[1175,937]	5	hSpCas9	negative selection	1214592
15192146	15192169	19	-	26627737	RPE1	viability after 12 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	1.143829246307999	[982]	[687,472]	6	hSpCas9	negative selection	1214593
15192370	15192393	19	+	26627737	RPE1	viability after 12 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	0.08365973216784073	[2069]	[668,504]	0	hSpCas9	negative selection	1214594
15197551	15197574	19	+	26627737	RPE1	viability after 12 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	1.6262181780410843	[1552]	[1390,1178]	8	hSpCas9	negative selection	1214595
15200801	15200824	19	-	26627737	RPE1	viability after 12 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	0.3255536290662082	[1155]	[480,291]	2	hSpCas9	negative selection	1214596
15191597	15191620	19	-	26627737	RPE1	viability after 15 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	1.0889783046985622	[684]	[372,449]	6	hSpCas9	negative selection	1296906
15191744	15191767	19	-	26627737	RPE1	viability after 15 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	0.5254517258243241	[2232]	[1037,784]	3	hSpCas9	negative selection	1296907
15192146	15192169	19	-	26627737	RPE1	viability after 15 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	0.8144720188105108	[982]	[599,381]	5	hSpCas9	negative selection	1296908
15192370	15192393	19	+	26627737	RPE1	viability after 15 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	0.19260111795282486	[2069]	[742,597]	1	hSpCas9	negative selection	1296909
15197551	15197574	19	+	26627737	RPE1	viability after 15 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	1.2227575183935087	[1552]	[866,1177]	7	hSpCas9	negative selection	1296910
15200801	15200824	19	-	26627737	RPE1	viability after 15 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	0.577955099849191	[1155]	[564,413]	3	hSpCas9	negative selection	1296911
15191597	15191620	19	-	26627737	RPE1	viability after 18 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	1.2892213017951983	[684]	[401,504]	7	hSpCas9	negative selection	1379221
15191744	15191767	19	-	26627737	RPE1	viability after 18 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	0.9876670184223264	[2232]	[1645,712]	6	hSpCas9	negative selection	1379222
15192146	15192169	19	-	26627737	RPE1	viability after 18 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	-0.2945938105952758	[982]	[209,222]	-2	hSpCas9	negative selection	1379223
15192370	15192393	19	+	26627737	RPE1	viability after 18 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	0.3548472204481794	[2069]	[696,732]	2	hSpCas9	negative selection	1379224
15197551	15197574	19	+	26627737	RPE1	viability after 18 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	1.349265971627247	[1552]	[901,1244]	7	hSpCas9	negative selection	1379225
15200801	15200824	19	-	26627737	RPE1	viability after 18 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	0.9011091632616536	[1155]	[672,485]	5	hSpCas9	negative selection	1379226
15191597	15191620	19	-	26627737	HeLa	viability after 8 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	0.2762875195680112	[538]	[312,179,359]	2	hSpCas9	negative selection	1461536
15191744	15191767	19	-	26627737	HeLa	viability after 8 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	0.5625406450083075	[1116]	[872,883,449]	5	hSpCas9	negative selection	1461537
15192146	15192169	19	-	26627737	HeLa	viability after 8 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	1.0939428969392904	[255]	[163,367,169]	8	hSpCas9	negative selection	1461538
15192370	15192393	19	+	26627737	HeLa	viability after 8 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	-0.02092458451368595	[666]	[143,427,256]	0	hSpCas9	negative selection	1461539
15197551	15197574	19	+	26627737	HeLa	viability after 8 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.36329874044139543	[1262]	[923,809,452]	3	hSpCas9	negative selection	1461540
15200801	15200824	19	-	26627737	HeLa	viability after 8 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	0.17276656786925537	[634]	[249,242,419]	1	hSpCas9	negative selection	1461541
15191597	15191620	19	-	26627737	HeLa	viability after 12 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	0.5593672466062651	[538]	[278,368,330]	5	hSpCas9	negative selection	1543851
15191744	15191767	19	-	26627737	HeLa	viability after 12 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	0.6296497686331972	[1116]	[914,661,576]	5	hSpCas9	negative selection	1543852
15192146	15192169	19	-	26627737	HeLa	viability after 12 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	1.0403719826675069	[255]	[264,171,221]	7	hSpCas9	negative selection	1543853
15192370	15192393	19	+	26627737	HeLa	viability after 12 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	0.48882079635189823	[666]	[592,239,348]	4	hSpCas9	negative selection	1543854
15197551	15197574	19	+	26627737	HeLa	viability after 12 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.5176518831709551	[1262]	[752,783,700]	4	hSpCas9	negative selection	1543855
15200801	15200824	19	-	26627737	HeLa	viability after 12 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	-0.18901483477292635	[634]	[230,169,295]	-2	hSpCas9	negative selection	1543856
15191597	15191620	19	-	26627737	HeLa	viability after 15 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	0.5801039510332282	[538]	[452,291,229]	5	hSpCas9	negative selection	1626166
15191744	15191767	19	-	26627737	HeLa	viability after 15 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	0.6239695604660374	[1116]	[736,795,557]	5	hSpCas9	negative selection	1626167
15192146	15192169	19	-	26627737	HeLa	viability after 15 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	-0.028637914913173135	[255]	[116,90,97]	0	hSpCas9	negative selection	1626168
15192370	15192393	19	+	26627737	HeLa	viability after 15 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	0.32938994921981557	[666]	[263,280,490]	2	hSpCas9	negative selection	1626169
15197551	15197574	19	+	26627737	HeLa	viability after 15 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.34067841350662076	[1262]	[350,800,817]	3	hSpCas9	negative selection	1626170
15200801	15200824	19	-	26627737	HeLa	viability after 15 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	0.11201844739154165	[634]	[252,154,442]	1	hSpCas9	negative selection	1626171
15191597	15191620	19	-	26627737	HeLa	viability after 18 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	0.5439882109962344	[538]	[283,246,229]	4	hSpCas9	negative selection	1708481
15191744	15191767	19	-	26627737	HeLa	viability after 18 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	0.6214380422295505	[1116]	[492,657,557]	5	hSpCas9	negative selection	1708482
15192146	15192169	19	-	26627737	HeLa	viability after 18 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	-0.08476681124742103	[255]	[71,73,97]	0	hSpCas9	negative selection	1708483
15192370	15192393	19	+	26627737	HeLa	viability after 18 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	0.31392588886075723	[666]	[168,233,490]	2	hSpCas9	negative selection	1708484
15197551	15197574	19	+	26627737	HeLa	viability after 18 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.3555143872105455	[1262]	[239,673,817]	3	hSpCas9	negative selection	1708485
15200801	15200824	19	-	26627737	HeLa	viability after 18 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	0.13354623550653133	[634]	[182,121,442]	1	hSpCas9	negative selection	1708486
15191597	15191620	19	-	26627737	HCT116	viability after 6 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	1.3077208486660772	[971]	[356,389]	7	hSpCas9	negative selection	1790796
15191744	15191767	19	-	26627737	HCT116	viability after 6 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	0.7001946400094223	[1592]	[451,381]	4	hSpCas9	negative selection	1790797
15192146	15192169	19	-	26627737	HCT116	viability after 6 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	2.2813417401140397	[264]	[411,86]	9	hSpCas9	negative selection	1790798
15192370	15192393	19	+	26627737	HCT116	viability after 6 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	1.282300247318619	[699]	[587,90]	6	hSpCas9	negative selection	1790799
15197551	15197574	19	+	26627737	HCT116	viability after 6 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.7978233322366057	[2407]	[806,575]	4	hSpCas9	negative selection	1790800
15200801	15200824	19	-	26627737	HCT116	viability after 6 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	1.3385480337353024	[640]	[259,251]	7	hSpCas9	negative selection	1790801
15191597	15191620	19	-	26627737	HCT116	viability after 8 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	0.42711163648682726	[333]	[223,192,323]	4	hSpCas9	negative selection	1873111
15191744	15191767	19	-	26627737	HCT116	viability after 8 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	-0.4322776152502581	[1297]	[477,644,466]	-5	hSpCas9	negative selection	1873112
15192146	15192169	19	-	26627737	HCT116	viability after 8 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	0.05320990818094473	[350]	[102,272,223]	0	hSpCas9	negative selection	1873113
15192370	15192393	19	+	26627737	HCT116	viability after 8 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	0.23842938406093594	[480]	[333,340,263]	2	hSpCas9	negative selection	1873114
15197551	15197574	19	+	26627737	HCT116	viability after 8 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.18318896441918087	[953]	[723,568,500]	2	hSpCas9	negative selection	1873115
15200801	15200824	19	-	26627737	HCT116	viability after 8 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	0.18865537446619562	[513]	[297,186,480]	2	hSpCas9	negative selection	1873116
15191597	15191620	19	-	26627737	HCT116	viability after 9 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	1.21137686225249	[971]	[891,370]	7	hSpCas9	negative selection	1955426
15191744	15191767	19	-	26627737	HCT116	viability after 9 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	0.4665567817151808	[1592]	[713,487]	3	hSpCas9	negative selection	1955427
15192146	15192169	19	-	26627737	HCT116	viability after 9 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	2.3245814151488835	[264]	[373,338]	9	hSpCas9	negative selection	1955428
15192370	15192393	19	+	26627737	HCT116	viability after 9 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	0.9678085255031499	[699]	[402,335]	6	hSpCas9	negative selection	1955429
15197551	15197574	19	+	26627737	HCT116	viability after 9 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.31397479611451895	[2407]	[824,778]	2	hSpCas9	negative selection	1955430
15200801	15200824	19	-	26627737	HCT116	viability after 9 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	1.4540039414587633	[640]	[421,505]	8	hSpCas9	negative selection	1955431
15191597	15191620	19	-	26627737	HCT116	viability after 12 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	0.6290829796789607	[333]	[339,255,211]	6	hSpCas9	negative selection	2037741
15191744	15191767	19	-	26627737	HCT116	viability after 12 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	-0.05153094828395943	[1297]	[617,652,706]	0	hSpCas9	negative selection	2037742
15192146	15192169	19	-	26627737	HCT116	viability after 12 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	0.797390004842395	[350]	[322,380,258]	7	hSpCas9	negative selection	2037743
15192370	15192393	19	+	26627737	HCT116	viability after 12 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	0.41697362097837853	[480]	[370,356,281]	4	hSpCas9	negative selection	2037744
15197551	15197574	19	+	26627737	HCT116	viability after 12 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.2307048247532617	[953]	[528,584,655]	2	hSpCas9	negative selection	2037745
15200801	15200824	19	-	26627737	HCT116	viability after 12 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	0.040199564227786255	[513]	[251,214,366]	0	hSpCas9	negative selection	2037746
15191597	15191620	19	-	26627737	HCT116	viability after 15 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	0.5351474603967304	[333]	[356,167,317]	5	hSpCas9	negative selection	2120056
15191744	15191767	19	-	26627737	HCT116	viability after 15 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	-0.25839516980949107	[1297]	[835,644,416]	-3	hSpCas9	negative selection	2120057
15192146	15192169	19	-	26627737	HCT116	viability after 15 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	0.533523323519318	[350]	[231,422,213]	5	hSpCas9	negative selection	2120058
15192370	15192393	19	+	26627737	HCT116	viability after 15 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	0.23048393468930217	[480]	[265,358,339]	2	hSpCas9	negative selection	2120059
15197551	15197574	19	+	26627737	HCT116	viability after 15 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.38746232442880024	[953]	[738,635,776]	4	hSpCas9	negative selection	2120060
15200801	15200824	19	-	26627737	HCT116	viability after 15 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	-0.039653425475640214	[513]	[321,356,187]	0	hSpCas9	negative selection	2120061
15191597	15191620	19	-	26627737	HCT116	viability after 18 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	0.44701727273779357	[333]	[183,220,256]	4	hSpCas9	negative selection	2202371
15191744	15191767	19	-	26627737	HCT116	viability after 18 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	-0.2302773840737995	[1297]	[437,598,564]	-2	hSpCas9	negative selection	2202372
15192146	15192169	19	-	26627737	HCT116	viability after 18 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	0.8808402047992978	[350]	[335,297,303]	7	hSpCas9	negative selection	2202373
15192370	15192393	19	+	26627737	HCT116	viability after 18 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	-0.23570231701998628	[480]	[234,168,189]	-2	hSpCas9	negative selection	2202374
15197551	15197574	19	+	26627737	HCT116	viability after 18 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.3031255779540192	[953]	[559,556,591]	2	hSpCas9	negative selection	2202375
15200801	15200824	19	-	26627737	HCT116	viability after 18 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	0.208547451925281	[513]	[315,355,179]	1	hSpCas9	negative selection	2202376
15197500	15197523	19	+	24336569	HL60	viability	AGGCAGGCAGCCTCCCGGGAGGG	NOTCH3	ENSG00000074181	-0.6605259999103681	[548]	[734]	-5	hSpCas9	negative selection	2280825
15197507	15197530	19	+	24336569	HL60	viability	CAGCCTCCCGGGAGGGCAGCTGG	NOTCH3	ENSG00000074181	1.0300442145880941	[307]	[1330]	7	hSpCas9	negative selection	2280826
15197513	15197536	19	-	24336569	HL60	viability	TTGCACCCAGCTGCCCTCCCGGG	NOTCH3	ENSG00000074181	0.33357339864994734	[647]	[1727]	3	hSpCas9	negative selection	2280827
15197533	15197556	19	+	24336569	HL60	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	1.0043514009033718	[566]	[2406]	7	hSpCas9	negative selection	2280828
15197539	15197562	19	-	24336569	HL60	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	0.22125494051830025	[498]	[1230]	2	hSpCas9	negative selection	2280829
15197546	15197569	19	+	24336569	HL60	viability	TTGCACACGGGCTTCCGTCCAGG	NOTCH3	ENSG00000074181	-0.22069989800006845	[374]	[680]	-2	hSpCas9	negative selection	2280830
15197551	15197574	19	+	24336569	HL60	viability	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.05139880659187113	[367]	[806]	0	hSpCas9	negative selection	2280831
15200844	15200867	19	+	24336569	HL60	viability	GGTGGCGGTGGCGGCGACATCGG	NOTCH3	ENSG00000074181	-0.5709155714736829	[1040]	[1482]	-5	hSpCas9	negative selection	2280832
15200851	15200874	19	+	24336569	HL60	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	0.14167757808138481	[824]	[1925]	1	hSpCas9	negative selection	2280833
15200857	15200880	19	+	24336569	HL60	viability	GCGACATCGGGCGACGGCGGCGG	NOTCH3	ENSG00000074181	-0.27715219813629044	[338]	[591]	-2	hSpCas9	negative selection	2280834
15197500	15197523	19	+	24336569	KBM7	viability	AGGCAGGCAGCCTCCCGGGAGGG	NOTCH3	ENSG00000074181	0.5839788719537675	[259]	[1062]	5	hSpCas9	negative selection	2348002
15197507	15197530	19	+	24336569	KBM7	viability	CAGCCTCCCGGGAGGGCAGCTGG	NOTCH3	ENSG00000074181	0.21351437338824447	[405]	[1283]	2	hSpCas9	negative selection	2348003
15197513	15197536	19	-	24336569	KBM7	viability	TTGCACCCAGCTGCCCTCCCGGG	NOTCH3	ENSG00000074181	0.18066269691351233	[1006]	[3112]	1	hSpCas9	negative selection	2348004
15197533	15197556	19	+	24336569	KBM7	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.3878819160828859	[776]	[2772]	3	hSpCas9	negative selection	2348005
15197539	15197562	19	-	24336569	KBM7	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.15028196619854367	[318]	[783]	-1	hSpCas9	negative selection	2348006
15197546	15197569	19	+	24336569	KBM7	viability	TTGCACACGGGCTTCCGTCCAGG	NOTCH3	ENSG00000074181	-1.371228310418768	[183]	[193]	-7	hSpCas9	negative selection	2348007
15197551	15197574	19	+	24336569	KBM7	viability	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.826510397793907	[324]	[1571]	7	hSpCas9	negative selection	2348008
15200844	15200867	19	+	24336569	KBM7	viability	GGTGGCGGTGGCGGCGACATCGG	NOTCH3	ENSG00000074181	-0.3191587775613861	[955]	[2089]	-3	hSpCas9	negative selection	2348009
15200851	15200874	19	+	24336569	KBM7	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.2651011447634857	[622]	[1413]	-2	hSpCas9	negative selection	2348010
15200857	15200880	19	+	24336569	KBM7	viability	GCGACATCGGGCGACGGCGGCGG	NOTCH3	ENSG00000074181	-0.34776232330096846	[341]	[732]	-3	hSpCas9	negative selection	2348011
15193965	15193988	19	-	25494202	A375	resistance to PLX-4720 (puromycin)	GTCTCAGCCTCCTGAGTAGCGGG	NOTCH3	ENSG00000074181	-0.29935217365489764	[71,81]	[9,16]	-1	dCas9-VP64	positive selection	2389887
15171920	15171943	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	GAGTTTCACTCTTGTTGCCCAGG	NOTCH3	ENSG00000074181	1.0342323942437988	[48,24]	[15,15]	4	dCas9-VP64	positive selection	2423119
15193907	15193930	19	-	25494202	A375	resistance to PLX-4720 (puromycin)	TTGTATTTTTAGTAGCGACGAGG	NOTCH3	ENSG00000074181	1.7949105880431917	[144,27]	[47,82]	6	dCas9-VP64	positive selection	2426794
15192652	15192675	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	CGCCTGTAATCCCAGAACTTTGG	NOTCH3	ENSG00000074181	-2.543268417376507	[115,242]	[7,4]	-9	dCas9-VP64	positive selection	2456223
15193965	15193988	19	-	25494202	A375	resistance to PLX-4720 (zeocin)	GTCTCAGCCTCCTGAGTAGCGGG	NOTCH3	ENSG00000074181	0.6576184974956476	[246,231]	[69,172]	5	dCas9-VP64	positive selection	2485142
15171920	15171943	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	GAGTTTCACTCTTGTTGCCCAGG	NOTCH3	ENSG00000074181	1.1207783393058013	[70,52]	[75,13]	7	dCas9-VP64	positive selection	2518374
15193907	15193930	19	-	25494202	A375	resistance to PLX-4720 (zeocin)	TTGTATTTTTAGTAGCGACGAGG	NOTCH3	ENSG00000074181	-0.8993522853905275	[42,195]	[21,18]	-8	dCas9-VP64	positive selection	2522049
15192652	15192675	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	CGCCTGTAATCCCAGAACTTTGG	NOTCH3	ENSG00000074181	-0.5948923258591747	[103,174]	[39,19]	-6	dCas9-VP64	positive selection	2551478
15191446	15191469	19	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CACAGTAGAAAGAAGCCACGCGG	NOTCH3	ENSG00000074181	-0.259307912344966	[3,3]	[3,1]	-4	hSpCas9	positive selection	3006104
15192394	15192417	19	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.18474324685365706	[2,3]	[3,2]	4	hSpCas9	positive selection	3006105
15192044	15192067	19	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	-0.3119405584742678	[1,2]	[2,0]	-4	hSpCas9	positive selection	3006106
15180081	15180104	19	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TGTAGCCCCCCATATAGCCACGG	NOTCH3	ENSG00000074181	0.2541611808763674	[3,4]	[4,3]	5	hSpCas9	positive selection	3006107
15191446	15191469	19	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CACAGTAGAAAGAAGCCACGCGG	NOTCH3	ENSG00000074181	-0.3620463109503288	[3,3]	[3,0]	-5	hSpCas9	positive selection	3073962
15192394	15192417	19	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.8628860811861112	[2,2]	[2,4]	9	hSpCas9	positive selection	3073963
15192044	15192067	19	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	-0.29457146736377327	[1,1]	[1,0]	-4	hSpCas9	positive selection	3073964
15180081	15180104	19	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TGTAGCCCCCCATATAGCCACGG	NOTCH3	ENSG00000074181	-0.046060252144925304	[3,3]	[2,2]	0	hSpCas9	positive selection	3073965
15197533	15197556		+	24336571	A375	resistance to PLX after 7 days	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.006964340419278292	[19,22]	[20,22]	0	hSpCas9	positive selection	3131210
15200895	15200918		-	24336571	A375	resistance to PLX after 7 days	CGGCCGGCCGCCATGGGGCCGGG	NOTCH3	ENSG00000074181	-0.17703229712923152	[3,2]	[2,2]	-5	hSpCas9	positive selection	3131211
15200851	15200874		+	24336571	A375	resistance to PLX after 7 days	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.45057792314426703	[6,5]	[4,4]	-9	hSpCas9	positive selection	3131212
15197533	15197556		+	24336571	A375	resistance to PLX after 14 days	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	1.0880531958818354	[13,16]	[15,14]	8	hSpCas9	positive selection	3189003
15200895	15200918		-	24336571	A375	resistance to PLX after 14 days	CGGCCGGCCGCCATGGGGCCGGG	NOTCH3	ENSG00000074181	0.17126043704030702	[3,2]	[1,1]	1	hSpCas9	positive selection	3189004
15200851	15200874		+	24336571	A375	resistance to PLX after 14 days	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.18363414209250584	[7,5]	[2,1]	-2	hSpCas9	positive selection	3189005
15197533	15197556		+	24336571	A375	viability after 7 days	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.05045422300482927	[21]	[19,22]	0	hSpCas9	negative selection	3246796
15200895	15200918		-	24336571	A375	viability after 7 days	CGGCCGGCCGCCATGGGGCCGGG	NOTCH3	ENSG00000074181	0.14169535363451802	[2]	[3,2]	2	hSpCas9	negative selection	3246797
15200851	15200874		+	24336571	A375	viability after 7 days	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	0.1222949460747691	[5]	[6,5]	1	hSpCas9	negative selection	3246798
15197533	15197556		+	24336571	A375	viability after 14 days	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	-0.43013151541722044	[21]	[13,16]	-5	hSpCas9	negative selection	3304589
15200895	15200918		-	24336571	A375	viability after 14 days	CGGCCGGCCGCCATGGGGCCGGG	NOTCH3	ENSG00000074181	0.2629176888738394	[2]	[3,2]	3	hSpCas9	negative selection	3304590
15200851	15200874		+	24336571	A375	viability after 14 days	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	0.14720688334532994	[5]	[7,5]	2	hSpCas9	negative selection	3304591
15192396	15192419	19	-	27383988	293T	resistance to West Nile virus (flavivirus)	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	-1.3463001335403568	[388,388]	[0,0]	-8	hSpCas9	positive selection	3382088
15197539	15197562	19	-	27383988	293T	resistance to West Nile virus (flavivirus)	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	0.9353981165584727	[79,79]	[0,0]	4	hSpCas9	positive selection	3382089
15200826	15200849	19	+	27383988	293T	resistance to West Nile virus (flavivirus)	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	6.257326211445835	[1,1]	[0,0]	9	hSpCas9	positive selection	3382090
15191445	15191468	19	+	26780180	HT29	viability (Avana library 4 designs)	CACAGTAGAAAGAAGCCACGCGG	NOTCH3	ENSG00000074181	1.56440039649237	[]	[]	6	hSpCas9	negative selection	3443962
15192393	15192416	19	+	26780180	HT29	viability (Avana library 4 designs)	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	1.81629231454756	[]	[]	7	hSpCas9	negative selection	3443963
15192044	15192067	19	-	26780180	HT29	viability (Avana library 4 designs)	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	0.160971251222068	[]	[]	0	hSpCas9	negative selection	3443964
15180080	15180103	19	+	26780180	HT29	viability (Avana library 4 designs)	TGTAGCCCCCCATATAGCCACGG	NOTCH3	ENSG00000074181	0.865466260524218	[]	[]	3	hSpCas9	negative selection	3443965
15192044	15192067	19	-	26780180	A375	viability (Avana lentiCRISPRv2)	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	2.1973901627725	[]	[]	3	hSpCas9	negative selection	3535913
15191445	15191468	19	+	26780180	A375	viability (Avana lentiCRISPRv2)	CACAGTAGAAAGAAGCCACGCGG	NOTCH3	ENSG00000074181	-0.8933297364735	[]	[]	-1	hSpCas9	negative selection	3535914
15180080	15180103	19	+	26780180	A375	viability (Avana lentiCRISPRv2)	TGTAGCCCCCCATATAGCCACGG	NOTCH3	ENSG00000074181	2.86034743027718	[]	[]	4	hSpCas9	negative selection	3535915
15192393	15192416	19	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.474539036563885	[]	[]	0	hSpCas9	negative selection	3535916
15189378	15189401	19	-	26780180	A375	viability (Avana lentiCRISPRv2)	TGTCAGCAACCCCTGCCACGAGG	NOTCH3	ENSG00000074181	6.9775929129215	[]	[]	9	hSpCas9	negative selection	3535917
15180708	15180731	19	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCAAGCTTCGGATGTCACAGAGG	NOTCH3	ENSG00000074181	2.16297530902443	[]	[]	3	hSpCas9	negative selection	3535918
15192044	15192067	19	-	26780180	A375	viability (Avana lentiGuide)	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	-3.7665178880112	[]	[]	-6	hSpCas9	negative selection	3644572
15191445	15191468	19	+	26780180	A375	viability (Avana lentiGuide)	CACAGTAGAAAGAAGCCACGCGG	NOTCH3	ENSG00000074181	-0.0788680438031596	[]	[]	0	hSpCas9	negative selection	3644573
15180080	15180103	19	+	26780180	A375	viability (Avana lentiGuide)	TGTAGCCCCCCATATAGCCACGG	NOTCH3	ENSG00000074181	2.07637273574841	[]	[]	2	hSpCas9	negative selection	3644574
15192393	15192416	19	+	26780180	A375	viability (Avana lentiGuide)	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	4.32667677982018	[]	[]	4	hSpCas9	negative selection	3644575
15189378	15189401	19	-	26780180	A375	viability (Avana lentiGuide)	TGTCAGCAACCCCTGCCACGAGG	NOTCH3	ENSG00000074181	8.73699872183723	[]	[]	6	hSpCas9	negative selection	3644576
15180708	15180731	19	+	26780180	A375	viability (Avana lentiGuide)	GCAAGCTTCGGATGTCACAGAGG	NOTCH3	ENSG00000074181	1.08148979083606	[]	[]	1	hSpCas9	negative selection	3644577
15192044	15192067	19	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	-0.44234100672288773	[4]	[3,2]	-6	hSpCas9	positive selection	3753231
15191445	15191468	19	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CACAGTAGAAAGAAGCCACGCGG	NOTCH3	ENSG00000074181	-0.2844210003582952	[4]	[4,2]	-4	hSpCas9	positive selection	3753232
15180080	15180103	19	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGTAGCCCCCCATATAGCCACGG	NOTCH3	ENSG00000074181	-0.037890633449191496	[5]	[5,4]	0	hSpCas9	positive selection	3753233
15192393	15192416	19	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.13936795864070423	[5]	[5,5]	3	hSpCas9	positive selection	3753234
15189378	15189401	19	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGTCAGCAACCCCTGCCACGAGG	NOTCH3	ENSG00000074181	0.42164293639434625	[3]	[5,4]	9	hSpCas9	positive selection	3753235
15180708	15180731	19	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCAAGCTTCGGATGTCACAGAGG	NOTCH3	ENSG00000074181	-0.2982444398101393	[4]	[4,2]	-4	hSpCas9	positive selection	3753236
15192044	15192067	19	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	-0.0644050974861251	[3]	[3,2]	-1	hSpCas9	positive selection	3861838
15191445	15191468	19	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CACAGTAGAAAGAAGCCACGCGG	NOTCH3	ENSG00000074181	-0.5717145760953686	[5]	[2,2]	-6	hSpCas9	positive selection	3861839
15180080	15180103	19	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGTAGCCCCCCATATAGCCACGG	NOTCH3	ENSG00000074181	-0.6158966604878701	[5]	[2,2]	-7	hSpCas9	positive selection	3861840
15192393	15192416	19	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.03381175119400626	[5]	[5,3]	0	hSpCas9	positive selection	3861841
15189378	15189401	19	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGTCAGCAACCCCTGCCACGAGG	NOTCH3	ENSG00000074181	-0.6569172019660487	[4]	[0,2]	-7	hSpCas9	positive selection	3861842
15180708	15180731	19	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCAAGCTTCGGATGTCACAGAGG	NOTCH3	ENSG00000074181	0.1023010351677551	[5]	[4,4]	2	hSpCas9	positive selection	3861843
15200826	15200849	19	+	26780180	A375	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	0.190167592406287	[]	[]	0	hSpCas9	negative selection	3973156
15197533	15197556	19	+	26780180	A375	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.525659546204801	[]	[]	1	hSpCas9	negative selection	3973157
15192396	15192419	19	-	26780180	A375	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	1.37723421771565	[]	[]	7	hSpCas9	negative selection	3973158
15192393	15192416	19	+	26780180	A375	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.580912230074465	[]	[]	1	hSpCas9	negative selection	3973159
15197539	15197562	19	-	26780180	A375	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	1.4154837892284	[]	[]	7	hSpCas9	negative selection	3973160
15200851	15200874	19	+	26780180	A375	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	1.40817479469262	[]	[]	7	hSpCas9	negative selection	3973161
15200826	15200849	19	+	26780180	HT29	viability (GeCKOv2 library)	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	0.238242009639752	[]	[]	0	hSpCas9	negative selection	4081122
15197533	15197556	19	+	26780180	HT29	viability (GeCKOv2 library)	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.542248321756378	[]	[]	1	hSpCas9	negative selection	4081123
15192396	15192419	19	-	26780180	HT29	viability (GeCKOv2 library)	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	2.12446045310332	[]	[]	9	hSpCas9	negative selection	4081124
15192393	15192416	19	+	26780180	HT29	viability (GeCKOv2 library)	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.252842112743584	[]	[]	0	hSpCas9	negative selection	4081125
15197539	15197562	19	-	26780180	HT29	viability (GeCKOv2 library)	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	1.347661292511	[]	[]	7	hSpCas9	negative selection	4081126
15200851	15200874	19	+	26780180	HT29	viability (GeCKOv2 library)	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	1.44401201179254	[]	[]	7	hSpCas9	negative selection	4081127
15197533	15197556	19	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.21844768130466558	[4]	[2,3]	5	hSpCas9	positive selection	4155900
15200895	15200918	19	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CGGCCGGCCGCCATGGGGCCGGG	NOTCH3	ENSG00000074181	-0.7896644154491539	[1]	[0,0]	-9	hSpCas9	positive selection	4155901
15200851	15200874	19	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.11759491490126361	[2]	[1,0]	-3	hSpCas9	positive selection	4155902
15197533	15197556	19	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.04146714687246089	[4]	[1,2,4,0]	0	hSpCas9	positive selection	4219922
15200895	15200918	19	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CGGCCGGCCGCCATGGGGCCGGG	NOTCH3	ENSG00000074181	1.2341615719879322	[0]	[0,3,1,0]	8	hSpCas9	positive selection	4219923
15200851	15200874	19	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.7064074016273749	[3]	[0,0,0,0]	-8	hSpCas9	positive selection	4219924
15200851	15200874	19	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.4794838736292399	[2]	[0,1]	-8	hSpCas9	positive selection	4286004
15192393	15192416	19	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.042945864164932734	[0]	[0,0]	0	hSpCas9	positive selection	4286005
15197533	15197556	19	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.2332964485763604	[3]	[4,1]	5	hSpCas9	positive selection	4286006
15192396	15192419	19	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.02272159000964169	[3]	[3,2]	0	hSpCas9	positive selection	4350261
15197539	15197562	19	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.23135055374012287	[1]	[1,0]	-5	hSpCas9	positive selection	4350262
15200826	15200849	19	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	0.23181190810909436	[0]	[0,0]	4	hSpCas9	positive selection	4350263
15180780	15180802	19	+	27760321	OCIAML3	viability	AGCGACCCCCGTTTTGACAAGG	NOTCH3	ENSG00000074181	0.0627690054968344	[779,606]	[473,677]	0	hSpCas9	negative selection	4423008
15181719	15181741	19	+	27760321	OCIAML3	viability	TCGTGGGCCGGCGAAACCAGGG	NOTCH3	ENSG00000074181	-0.13949781265339095	[553,462]	[280,461]	-1	hSpCas9	negative selection	4423009
15187306	15187328	19	-	27760321	OCIAML3	viability	ACGCTGTGTGATCGCAACGTGG	NOTCH3	ENSG00000074181	-0.3335279969075887	[913,813]	[442,655]	-4	hSpCas9	negative selection	4423010
15187881	15187903	19	-	27760321	OCIAML3	viability	TACGAGTGCCGCTGTGCCGAGG	NOTCH3	ENSG00000074181	0.45452070847089576	[1105,878]	[1008,1119]	5	hSpCas9	negative selection	4423011
15192044	15192066	19	+	27760321	OCIAML3	viability	CCGCGGGGTTCTCACATAGTGG	NOTCH3	ENSG00000074181	0.10011155307172367	[593,429]	[404,450]	1	hSpCas9	negative selection	4423012
15180780	15180802	19	+	27760321	OCIAML2	viability	AGCGACCCCCGTTTTGACAAGG	NOTCH3	ENSG00000074181	0.3931428700747266	[779,606]	[618,879]	5	hSpCas9	negative selection	4506471
15181719	15181741	19	+	27760321	OCIAML2	viability	TCGTGGGCCGGCGAAACCAGGG	NOTCH3	ENSG00000074181	0.27853073302037523	[553,462]	[464,538]	3	hSpCas9	negative selection	4506472
15187306	15187328	19	-	27760321	OCIAML2	viability	ACGCTGTGTGATCGCAACGTGG	NOTCH3	ENSG00000074181	0.518784704392133	[913,813]	[841,1207]	7	hSpCas9	negative selection	4506473
15187881	15187903	19	-	27760321	OCIAML2	viability	TACGAGTGCCGCTGTGCCGAGG	NOTCH3	ENSG00000074181	0.19830049115656867	[1105,878]	[789,1080]	2	hSpCas9	negative selection	4506474
15192044	15192066	19	+	27760321	OCIAML2	viability	CCGCGGGGTTCTCACATAGTGG	NOTCH3	ENSG00000074181	0.003017644294515509	[593,429]	[353,485]	0	hSpCas9	negative selection	4506475
15180780	15180802	19	+	27760321	MV411	viability	AGCGACCCCCGTTTTGACAAGG	NOTCH3	ENSG00000074181	0.22054286250048316	[779,606]	[194,1031]	1	hSpCas9	negative selection	4589934
15181719	15181741	19	+	27760321	MV411	viability	TCGTGGGCCGGCGAAACCAGGG	NOTCH3	ENSG00000074181	0.2986785907096073	[553,462]	[251,649]	2	hSpCas9	negative selection	4589935
15187306	15187328	19	-	27760321	MV411	viability	ACGCTGTGTGATCGCAACGTGG	NOTCH3	ENSG00000074181	-0.003964042322813444	[913,813]	[514,646]	0	hSpCas9	negative selection	4589936
15187881	15187903	19	-	27760321	MV411	viability	TACGAGTGCCGCTGTGCCGAGG	NOTCH3	ENSG00000074181	0.2932235684911164	[1105,878]	[873,682]	2	hSpCas9	negative selection	4589937
15192044	15192066	19	+	27760321	MV411	viability	CCGCGGGGTTCTCACATAGTGG	NOTCH3	ENSG00000074181	-0.46760363579566366	[593,429]	[151,376]	-3	hSpCas9	negative selection	4589938
15180780	15180802	19	+	27760321	HL60	viability	AGCGACCCCCGTTTTGACAAGG	NOTCH3	ENSG00000074181	0.05785121604089505	[779,606]	[637,529]	0	hSpCas9	negative selection	4673397
15181719	15181741	19	+	27760321	HL60	viability	TCGTGGGCCGGCGAAACCAGGG	NOTCH3	ENSG00000074181	-0.5558733550656414	[553,462]	[261,301]	-6	hSpCas9	negative selection	4673398
15187306	15187328	19	-	27760321	HL60	viability	ACGCTGTGTGATCGCAACGTGG	NOTCH3	ENSG00000074181	0.092125004665923	[913,813]	[774,725]	1	hSpCas9	negative selection	4673399
15187881	15187903	19	-	27760321	HL60	viability	TACGAGTGCCGCTGTGCCGAGG	NOTCH3	ENSG00000074181	-0.1739953415148222	[1105,878]	[589,845]	-2	hSpCas9	negative selection	4673400
15192044	15192066	19	+	27760321	HL60	viability	CCGCGGGGTTCTCACATAGTGG	NOTCH3	ENSG00000074181	0.21182849800872786	[593,429]	[532,422]	2	hSpCas9	negative selection	4673401
15180780	15180802	19	+	27760321	HT1080	viability	AGCGACCCCCGTTTTGACAAGG	NOTCH3	ENSG00000074181	1.0389864243127092	[606,473]	[472,408]	5	hSpCas9	negative selection	4756860
15181719	15181741	19	+	27760321	HT1080	viability	TCGTGGGCCGGCGAAACCAGGG	NOTCH3	ENSG00000074181	0.5792316679763506	[462,360]	[259,228]	3	hSpCas9	negative selection	4756861
15187306	15187328	19	-	27760321	HT1080	viability	ACGCTGTGTGATCGCAACGTGG	NOTCH3	ENSG00000074181	0.25310636463176084	[813,634]	[458,217]	1	hSpCas9	negative selection	4756862
15187881	15187903	19	-	27760321	HT1080	viability	TACGAGTGCCGCTGTGCCGAGG	NOTCH3	ENSG00000074181	1.2067350419909537	[878,685]	[687,753]	6	hSpCas9	negative selection	4756863
15192044	15192066	19	+	27760321	HT1080	viability	CCGCGGGGTTCTCACATAGTGG	NOTCH3	ENSG00000074181	0.5470942006218019	[429,335]	[242,200]	3	hSpCas9	negative selection	4756864
15180780	15180802	19	+	27760321	HT29	viability after 7 days	AGCGACCCCCGTTTTGACAAGG	NOTCH3	ENSG00000074181	-0.02705044995586614	[606,473]	[889,731,459]	0	hSpCas9	negative selection	4840323
15181719	15181741	19	+	27760321	HT29	viability after 7 days	TCGTGGGCCGGCGAAACCAGGG	NOTCH3	ENSG00000074181	-0.2177005358550697	[462,360]	[586,641,164]	-3	hSpCas9	negative selection	4840324
15187306	15187328	19	-	27760321	HT29	viability after 7 days	ACGCTGTGTGATCGCAACGTGG	NOTCH3	ENSG00000074181	-0.06376628605512635	[813,634]	[716,960,966]	-1	hSpCas9	negative selection	4840325
15187881	15187903	19	-	27760321	HT29	viability after 7 days	TACGAGTGCCGCTGTGCCGAGG	NOTCH3	ENSG00000074181	0.10853179691942882	[878,685]	[1146,1050,1063]	1	hSpCas9	negative selection	4840326
15192044	15192066	19	+	27760321	HT29	viability after 7 days	CCGCGGGGTTCTCACATAGTGG	NOTCH3	ENSG00000074181	0.548419186863628	[429,335]	[936,611,643]	8	hSpCas9	negative selection	4840327
15180780	15180802	19	+	27760321	HT29	viability after 25 days	AGCGACCCCCGTTTTGACAAGG	NOTCH3	ENSG00000074181	0.134381025943068	[606,473]	[556,862,613]	1	hSpCas9	negative selection	4923786
15181719	15181741	19	+	27760321	HT29	viability after 25 days	TCGTGGGCCGGCGAAACCAGGG	NOTCH3	ENSG00000074181	0.19750643081910627	[462,360]	[539,416,675]	2	hSpCas9	negative selection	4923787
15187306	15187328	19	-	27760321	HT29	viability after 25 days	ACGCTGTGTGATCGCAACGTGG	NOTCH3	ENSG00000074181	0.3029365150715624	[813,634]	[1165,870,1015]	3	hSpCas9	negative selection	4923788
15187881	15187903	19	-	27760321	HT29	viability after 25 days	TACGAGTGCCGCTGTGCCGAGG	NOTCH3	ENSG00000074181	0.5816660205801094	[878,685]	[1227,1400,1396]	6	hSpCas9	negative selection	4923789
15192044	15192066	19	+	27760321	HT29	viability after 25 days	CCGCGGGGTTCTCACATAGTGG	NOTCH3	ENSG00000074181	0.10653473106450922	[429,335]	[286,353,819]	1	hSpCas9	negative selection	4923790
15180780	15180802	19	+	27760321	HT29	viability after 22 days	AGCGACCCCCGTTTTGACAAGG	NOTCH3	ENSG00000074181	0.47597442603975715	[606,473]	[936,1052,612]	5	hSpCas9	negative selection	5007249
15181719	15181741	19	+	27760321	HT29	viability after 22 days	TCGTGGGCCGGCGAAACCAGGG	NOTCH3	ENSG00000074181	0.10660566684180708	[462,360]	[373,560,607]	1	hSpCas9	negative selection	5007250
15187306	15187328	19	-	27760321	HT29	viability after 22 days	ACGCTGTGTGATCGCAACGTGG	NOTCH3	ENSG00000074181	0.36706652297193987	[813,634]	[1207,851,1177]	4	hSpCas9	negative selection	5007251
15187881	15187903	19	-	27760321	HT29	viability after 22 days	TACGAGTGCCGCTGTGCCGAGG	NOTCH3	ENSG00000074181	0.5010549121638781	[878,685]	[1284,1436,1116]	5	hSpCas9	negative selection	5007252
15192044	15192066	19	+	27760321	HT29	viability after 22 days	CCGCGGGGTTCTCACATAGTGG	NOTCH3	ENSG00000074181	0.30358368320767637	[429,335]	[516,502,620]	3	hSpCas9	negative selection	5007253
15180780	15180802	19	+	27760321	HT29	viability after 19 days	AGCGACCCCCGTTTTGACAAGG	NOTCH3	ENSG00000074181	0.3123460559882719	[606,473]	[958,827,543]	3	hSpCas9	negative selection	5090712
15181719	15181741	19	+	27760321	HT29	viability after 19 days	TCGTGGGCCGGCGAAACCAGGG	NOTCH3	ENSG00000074181	0.42131072114937007	[462,360]	[624,452,806]	4	hSpCas9	negative selection	5090713
15187306	15187328	19	-	27760321	HT29	viability after 19 days	ACGCTGTGTGATCGCAACGTGG	NOTCH3	ENSG00000074181	0.43248129758448606	[813,634]	[1195,1101,1065]	4	hSpCas9	negative selection	5090714
15187881	15187903	19	-	27760321	HT29	viability after 19 days	TACGAGTGCCGCTGTGCCGAGG	NOTCH3	ENSG00000074181	0.5567368277937743	[878,685]	[1107,1168,1636]	5	hSpCas9	negative selection	5090715
15192044	15192066	19	+	27760321	HT29	viability after 19 days	CCGCGGGGTTCTCACATAGTGG	NOTCH3	ENSG00000074181	0.2065717862684511	[429,335]	[487,431,590]	2	hSpCas9	negative selection	5090716
15180780	15180802	19	+	27760321	HT29	viability after 16 days	AGCGACCCCCGTTTTGACAAGG	NOTCH3	ENSG00000074181	0.23538504459931664	[606,473]	[537,1024,547]	2	hSpCas9	negative selection	5174175
15181719	15181741	19	+	27760321	HT29	viability after 16 days	TCGTGGGCCGGCGAAACCAGGG	NOTCH3	ENSG00000074181	0.15346797161401207	[462,360]	[523,548,464]	1	hSpCas9	negative selection	5174176
15187306	15187328	19	-	27760321	HT29	viability after 16 days	ACGCTGTGTGATCGCAACGTGG	NOTCH3	ENSG00000074181	0.11279430418884662	[813,634]	[945,907,780]	1	hSpCas9	negative selection	5174177
15187881	15187903	19	-	27760321	HT29	viability after 16 days	TACGAGTGCCGCTGTGCCGAGG	NOTCH3	ENSG00000074181	0.376300572889122	[878,685]	[1236,1189,989]	4	hSpCas9	negative selection	5174178
15192044	15192066	19	+	27760321	HT29	viability after 16 days	CCGCGGGGTTCTCACATAGTGG	NOTCH3	ENSG00000074181	0.536193254156453	[429,335]	[495,634,720]	6	hSpCas9	negative selection	5174179
15180780	15180802	19	+	27760321	HT29	viability after 13 days	AGCGACCCCCGTTTTGACAAGG	NOTCH3	ENSG00000074181	0.5035125762218788	[606,473]	[954,1102,624]	6	hSpCas9	negative selection	5257638
15181719	15181741	19	+	27760321	HT29	viability after 13 days	TCGTGGGCCGGCGAAACCAGGG	NOTCH3	ENSG00000074181	0.21868591164365928	[462,360]	[667,407,589]	2	hSpCas9	negative selection	5257639
15187306	15187328	19	-	27760321	HT29	viability after 13 days	ACGCTGTGTGATCGCAACGTGG	NOTCH3	ENSG00000074181	0.21106048801753197	[813,634]	[683,1259,974]	2	hSpCas9	negative selection	5257640
15187881	15187903	19	-	27760321	HT29	viability after 13 days	TACGAGTGCCGCTGTGCCGAGG	NOTCH3	ENSG00000074181	0.3597234109184704	[878,685]	[926,1336,1226]	4	hSpCas9	negative selection	5257641
15192044	15192066	19	+	27760321	HT29	viability after 13 days	CCGCGGGGTTCTCACATAGTGG	NOTCH3	ENSG00000074181	0.3900004434916544	[429,335]	[687,416,637]	5	hSpCas9	negative selection	5257642
15180780	15180802	19	+	27760321	HT29	viability after 10 days	AGCGACCCCCGTTTTGACAAGG	NOTCH3	ENSG00000074181	0.3465914218015369	[606,473]	[1031,1035,518]	5	hSpCas9	negative selection	5341101
15181719	15181741	19	+	27760321	HT29	viability after 10 days	TCGTGGGCCGGCGAAACCAGGG	NOTCH3	ENSG00000074181	0.05873948393760961	[462,360]	[626,591,392]	0	hSpCas9	negative selection	5341102
15187306	15187328	19	-	27760321	HT29	viability after 10 days	ACGCTGTGTGATCGCAACGTGG	NOTCH3	ENSG00000074181	-0.41620342848511616	[813,634]	[686,643,700]	-5	hSpCas9	negative selection	5341103
15187881	15187903	19	-	27760321	HT29	viability after 10 days	TACGAGTGCCGCTGTGCCGAGG	NOTCH3	ENSG00000074181	0.32680945518297233	[878,685]	[1506,1240,934]	4	hSpCas9	negative selection	5341104
15192044	15192066	19	+	27760321	HT29	viability after 10 days	CCGCGGGGTTCTCACATAGTGG	NOTCH3	ENSG00000074181	0.4285614501258088	[429,335]	[423,664,837]	6	hSpCas9	negative selection	5341105
15180780	15180802	19	+	27760321	MOLM13	viability	AGCGACCCCCGTTTTGACAAGG	NOTCH3	ENSG00000074181	0.3225483467259471	[779,606]	[641,352]	2	hSpCas9	negative selection	5424564
15181719	15181741	19	+	27760321	MOLM13	viability	TCGTGGGCCGGCGAAACCAGGG	NOTCH3	ENSG00000074181	0.6465531893773486	[553,462]	[429,461]	4	hSpCas9	negative selection	5424565
15187306	15187328	19	-	27760321	MOLM13	viability	ACGCTGTGTGATCGCAACGTGG	NOTCH3	ENSG00000074181	0.07288576076558817	[913,813]	[740,316]	0	hSpCas9	negative selection	5424566
15187881	15187903	19	-	27760321	MOLM13	viability	TACGAGTGCCGCTGTGCCGAGG	NOTCH3	ENSG00000074181	1.072429663543491	[1105,878]	[1507,882]	7	hSpCas9	negative selection	5424567
15192044	15192066	19	+	27760321	MOLM13	viability	CCGCGGGGTTCTCACATAGTGG	NOTCH3	ENSG00000074181	0.7952179481724554	[593,429]	[94,837]	5	hSpCas9	negative selection	5424568
15200533	15200556	19	+	27661255	K562	viability	GCTCCCAGTCTCGGACTCCTGGG	NOTCH3	ENSG00000074181	0.45595720795301464	[333,333]	[379,353]	9	dCas9-KRAB	negative selection	5497106
15200536	15200559	19	-	27661255	K562	viability	GGACCCAGGAGTCCGAGACTGGG	NOTCH3	ENSG00000074181	-0.06617106608707052	[922,994]	[835,640]	-3	dCas9-KRAB	negative selection	5497107
15200754	15200777	19	-	27661255	K562	viability	GGACCTGGCGGATGGGACGAGGG	NOTCH3	ENSG00000074181	0.06133792447501485	[992,1189]	[1037,794]	2	dCas9-KRAB	negative selection	5497108
15200851	15200874	19	+	27260156	BXPC3	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	0.00838805506664897	[272]	[225,276,307,350]	0	hSpCas9	negative selection	5558464
15192393	15192416	19	+	27260156	BXPC3	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.27633173025326574	[44]	[47,18,28,61]	-6	hSpCas9	negative selection	5558465
15197533	15197556	19	+	27260156	BXPC3	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.5017929492866973	[516]	[678,805,690,902]	9	hSpCas9	negative selection	5558466
15192396	15192419	19	-	27260156	BXPC3	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.0806954324041591	[898]	[834,967,1084,1116]	1	hSpCas9	negative selection	5622721
15197539	15197562	19	-	27260156	BXPC3	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.17918942746343292	[180]	[142,110,203,222]	-4	hSpCas9	negative selection	5622722
15200826	15200849	19	+	27260156	BXPC3	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	-0.14948330682952182	[12]	[1,18,5,23]	-3	hSpCas9	negative selection	5622723
15200851	15200874	19	+	27260156	A673	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.08845248785840454	[272]	[330,328,252,322]	-2	hSpCas9	negative selection	5679715
15192393	15192416	19	+	27260156	A673	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.1101104321066253	[44]	[55,53,92,27]	2	hSpCas9	negative selection	5679716
15197533	15197556	19	+	27260156	A673	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.4756269431829836	[516]	[849,782,922,896]	9	hSpCas9	negative selection	5679717
15192396	15192419	19	-	27260156	A673	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.12172164179399703	[898]	[1118,1254,1056,1261]	3	hSpCas9	negative selection	5743972
15197539	15197562	19	-	27260156	A673	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.2380712281121089	[180]	[213,177,185,160]	-5	hSpCas9	negative selection	5743973
15200826	15200849	19	+	27260156	A673	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	-1.017008008321274	[12]	[2,4,18,2]	-9	hSpCas9	negative selection	5743974
15200851	15200874	19	+	27260156	A375	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.584130926189128	[272]	[337,169,207,137]	-7	hSpCas9	negative selection	5800966
15192393	15192416	19	+	27260156	A375	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.8082224816308448	[44]	[28,41,14,34]	-7	hSpCas9	negative selection	5800967
15197533	15197556	19	+	27260156	A375	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.32562803618602926	[516]	[732,1071,674,605]	5	hSpCas9	negative selection	5800968
15192396	15192419	19	-	27260156	A375	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.12537572389344298	[898]	[1241,1373,1074,942]	1	hSpCas9	negative selection	5865223
15197539	15197562	19	-	27260156	A375	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.33172838643499514	[180]	[282,174,147,77]	-5	hSpCas9	negative selection	5865224
15200826	15200849	19	+	27260156	A375	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	-0.03948763058926641	[12]	[5,10,40,1]	0	hSpCas9	negative selection	5865225
15200851	15200874	19	+	27260156	COLO741	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.062229276160062796	[272]	[483,210,319]	-1	hSpCas9	negative selection	5922217
15192393	15192416	19	+	27260156	COLO741	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.10269800441561516	[44]	[29,80,47]	-2	hSpCas9	negative selection	5922218
15197533	15197556	19	+	27260156	COLO741	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.487442814917155	[516]	[926,960,890]	8	hSpCas9	negative selection	5922219
15192396	15192419	19	-	27260156	COLO741	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.19609685151623846	[898]	[1339,1419,1195]	4	hSpCas9	negative selection	5986474
15197539	15197562	19	-	27260156	COLO741	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.09108508200980614	[180]	[249,261,146]	-2	hSpCas9	negative selection	5986475
15200826	15200849	19	+	27260156	COLO741	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	-0.7630615344413068	[12]	[4,0,21]	-9	hSpCas9	negative selection	5986476
15200851	15200874	19	+	27260156	CAL120	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	0.383653851707638	[272]	[598,372,381]	6	hSpCas9	negative selection	6043468
15192393	15192416	19	+	27260156	CAL120	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.4779392790835284	[44]	[33,63,21]	-6	hSpCas9	negative selection	6043469
15197533	15197556	19	+	27260156	CAL120	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.48137843059325425	[516]	[798,970,908]	7	hSpCas9	negative selection	6043470
15192396	15192419	19	-	27260156	CAL120	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.47273053057900416	[898]	[1818,1333,1543]	7	hSpCas9	negative selection	6107725
15197539	15197562	19	-	27260156	CAL120	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.6727849731698681	[180]	[266,105,70]	-7	hSpCas9	negative selection	6107726
15200826	15200849	19	+	27260156	CAL120	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	-2.5116789743387766	[12]	[5,0,1]	-9	hSpCas9	negative selection	6107727
15200851	15200874	19	+	27260156	CADOES1	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.23967566676638785	[272]	[246,149,220,242]	-4	hSpCas9	negative selection	6164719
15192393	15192416	19	+	27260156	CADOES1	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.6215580456881882	[44]	[13,75,44,124]	8	hSpCas9	negative selection	6164720
15197533	15197556	19	+	27260156	CADOES1	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.7217867998636055	[516]	[634,821,730,991]	9	hSpCas9	negative selection	6164721
15192396	15192419	19	-	27260156	CADOES1	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	-0.2880996769014714	[898]	[645,551,724,820]	-5	hSpCas9	negative selection	6228976
15197539	15197562	19	-	27260156	CADOES1	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.5910225677329142	[180]	[137,114,106,85]	-8	hSpCas9	negative selection	6228977
15200826	15200849	19	+	27260156	CADOES1	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	0.9639049553116159	[12]	[5,49,25,11]	9	hSpCas9	negative selection	6228978
15200851	15200874	19	+	27260156	EWS502	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.24510589129725535	[272]	[193,301,263,216]	-4	hSpCas9	negative selection	6285970
15192393	15192416	19	+	27260156	EWS502	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.7148042612864685	[44]	[12,25,40,38]	-8	hSpCas9	negative selection	6285971
15197533	15197556	19	+	27260156	EWS502	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.5360111587119474	[516]	[769,673,908,831]	8	hSpCas9	negative selection	6285972
15192396	15192419	19	-	27260156	EWS502	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.058731270655130396	[898]	[758,946,1115,1186]	1	hSpCas9	negative selection	6350227
15197539	15197562	19	-	27260156	EWS502	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	0.1394892402486536	[180]	[172,149,293,236]	2	hSpCas9	negative selection	6350228
15200826	15200849	19	+	27260156	EWS502	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	0.48010592506411953	[12]	[32,8,20,11]	8	hSpCas9	negative selection	6350229
15200851	15200874	19	+	27260156	EW8	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.15937781049188093	[272]	[320,146,97,255]	-3	hSpCas9	negative selection	6407221
15192393	15192416	19	+	27260156	EW8	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.6142756260482769	[44]	[41,34,13,7]	-8	hSpCas9	negative selection	6407222
15197533	15197556	19	+	27260156	EW8	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.43721522700754134	[516]	[665,622,471,533]	7	hSpCas9	negative selection	6407223
15192396	15192419	19	-	27260156	EW8	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.026380693387410004	[898]	[911,669,612,810]	0	hSpCas9	negative selection	6471478
15197539	15197562	19	-	27260156	EW8	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	0.15090940963609834	[180]	[228,66,154,207]	2	hSpCas9	negative selection	6471479
15200826	15200849	19	+	27260156	EW8	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	-0.2847990191661136	[12]	[8,23,0,1]	-5	hSpCas9	negative selection	6471480
15200851	15200874	19	+	27260156	CORL105	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.4078896666128108	[272]	[316,150,235,262]	-6	hSpCas9	negative selection	6528472
15192393	15192416	19	+	27260156	CORL105	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.9943796098646938	[44]	[17,13,34,39]	-9	hSpCas9	negative selection	6528473
15197533	15197556	19	+	27260156	CORL105	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.35624185930990815	[516]	[793,768,870,680]	6	hSpCas9	negative selection	6528474
15192396	15192419	19	-	27260156	CORL105	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.16054722841890334	[898]	[1080,1261,1251,1116]	3	hSpCas9	negative selection	6592729
15197539	15197562	19	-	27260156	CORL105	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.07080242488288668	[180]	[173,188,263,188]	-1	hSpCas9	negative selection	6592730
15200826	15200849	19	+	27260156	CORL105	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	0.3727808380892714	[12]	[35,22,10,7]	7	hSpCas9	negative selection	6592731
15200851	15200874	19	+	27260156	HS294T	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.3776211316422512	[272]	[51,81,79,119]	-5	hSpCas9	negative selection	6649723
15192393	15192416	19	+	27260156	HS294T	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.4517876638149265	[44]	[3,9,23,13]	-6	hSpCas9	negative selection	6649724
15197533	15197556	19	+	27260156	HS294T	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	1.037425548652101	[516]	[392,278,353,661]	9	hSpCas9	negative selection	6649725
15192396	15192419	19	-	27260156	HS294T	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.6506678453572998	[898]	[821,507,465,321]	8	hSpCas9	negative selection	6713980
15197539	15197562	19	-	27260156	HS294T	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.6603895813045504	[180]	[53,57,26,34]	-7	hSpCas9	negative selection	6713981
15200826	15200849	19	+	27260156	HS294T	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	-0.539580363463414	[12]	[1,4,2,3]	-6	hSpCas9	negative selection	6713982
15200851	15200874	19	+	27260156	HCC44	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	0.17932806658679035	[272]	[328,262,427,397]	3	hSpCas9	negative selection	6770974
15192393	15192416	19	+	27260156	HCC44	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.5085627137556488	[44]	[123,30,23,110]	8	hSpCas9	negative selection	6770975
15197533	15197556	19	+	27260156	HCC44	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.7904741778154349	[516]	[941,991,1231,908]	9	hSpCas9	negative selection	6770976
15192396	15192419	19	-	27260156	HCC44	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.23325176010115656	[898]	[868,1139,1427,1346]	4	hSpCas9	negative selection	6835231
15197539	15197562	19	-	27260156	HCC44	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	0.044374781687551934	[180]	[255,238,179,163]	0	hSpCas9	negative selection	6835232
15200826	15200849	19	+	27260156	HCC44	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	0.8456463885409953	[12]	[23,0,6,71]	9	hSpCas9	negative selection	6835233
15200851	15200874	19	+	27260156	G402	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.7904499830825916	[272]	[228,223,115,206]	-7	hSpCas9	negative selection	6892225
15192393	15192416	19	+	27260156	G402	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-1.6297223247244275	[44]	[0,6,44,14]	-9	hSpCas9	negative selection	6892226
15197533	15197556	19	+	27260156	G402	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.6412577881268894	[516]	[1071,1064,1118,706]	7	hSpCas9	negative selection	6892227
15192396	15192419	19	-	27260156	G402	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	-0.03133110938760897	[898]	[1107,907,1326,947]	0	hSpCas9	negative selection	6956482
15197539	15197562	19	-	27260156	G402	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.10658786174945845	[180]	[350,148,290,53]	-1	hSpCas9	negative selection	6956483
15200826	15200849	19	+	27260156	G402	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	-2.0518334251676764	[12]	[1,0,10,0]	-9	hSpCas9	negative selection	6956484
15200851	15200874	19	+	27260156	L33	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.7021034036855457	[272]	[178,46,137,157]	-9	hSpCas9	negative selection	7013476
15192393	15192416	19	+	27260156	L33	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.4114538547265285	[44]	[31,22,13,24]	-7	hSpCas9	negative selection	7013477
15197533	15197556	19	+	27260156	L33	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.48154358535411623	[516]	[756,246,461,790]	8	hSpCas9	negative selection	7013478
15192396	15192419	19	-	27260156	L33	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	-0.12640467784727338	[898]	[685,341,548,902]	-3	hSpCas9	negative selection	7077733
15197539	15197562	19	-	27260156	L33	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.4476614976448414	[180]	[98,33,87,208]	-8	hSpCas9	negative selection	7077734
15200826	15200849	19	+	27260156	L33	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	0.0924243912432674	[12]	[33,3,1,7]	2	hSpCas9	negative selection	7077735
15200851	15200874	19	+	27260156	K562	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.5453168969846703	[272]	[274,80,109,197]	-6	hSpCas9	negative selection	7134727
15192393	15192416	19	+	27260156	K562	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.6400786843403394	[44]	[7,10,34,43]	-6	hSpCas9	negative selection	7134728
15197533	15197556	19	+	27260156	K562	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.7909829591456711	[516]	[786,859,970,581]	8	hSpCas9	negative selection	7134729
15192396	15192419	19	-	27260156	K562	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.32392262195856825	[898]	[861,1158,953,1010]	4	hSpCas9	negative selection	7198984
15197539	15197562	19	-	27260156	K562	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-1.3473900349754853	[180]	[26,53,49,111]	-8	hSpCas9	negative selection	7198985
15200826	15200849	19	+	27260156	K562	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	-0.8427967494059576	[12]	[6,17,0,0]	-7	hSpCas9	negative selection	7198986
15200851	15200874	19	+	27260156	HT29	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.2227202738922217	[272]	[268,282,358,229]	-4	hSpCas9	negative selection	7255978
15192393	15192416	19	+	27260156	HT29	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.2717495076973906	[44]	[37,95,34,18]	-5	hSpCas9	negative selection	7255979
15197533	15197556	19	+	27260156	HT29	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.43906310918237523	[516]	[874,880,724,916]	8	hSpCas9	negative selection	7255980
15192396	15192419	19	-	27260156	HT29	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	-0.10174705066508927	[898]	[1048,1042,998,983]	-2	hSpCas9	negative selection	7320235
15197539	15197562	19	-	27260156	HT29	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.2718117417848469	[180]	[165,121,239,191]	-5	hSpCas9	negative selection	7320236
15200826	15200849	19	+	27260156	HT29	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	0.08773804566924959	[12]	[15,22,15,12]	1	hSpCas9	negative selection	7320237
15200851	15200874	19	+	27260156	MHHES1	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.43523783350778367	[272]	[196,253,354,122]	-7	hSpCas9	negative selection	7377229
15192393	15192416	19	+	27260156	MHHES1	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.3489751020138683	[44]	[38,91,16,19]	-6	hSpCas9	negative selection	7377230
15197533	15197556	19	+	27260156	MHHES1	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.29637663059964897	[516]	[1003,670,737,509]	5	hSpCas9	negative selection	7377231
15192396	15192419	19	-	27260156	MHHES1	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.048813570899370884	[898]	[1120,1162,881,1023]	0	hSpCas9	negative selection	7441486
15197539	15197562	19	-	27260156	MHHES1	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.281706917024926	[180]	[256,111,206,109]	-5	hSpCas9	negative selection	7441487
15200826	15200849	19	+	27260156	MHHES1	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	1.147245961397604	[12]	[3,45,74,7]	9	hSpCas9	negative selection	7441488
15200851	15200874	19	+	27260156	MEWO	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.0752178999499249	[272]	[349,259,137]	-2	hSpCas9	negative selection	7498480
15192393	15192416	19	+	27260156	MEWO	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.45164444288205985	[44]	[13,49,24]	-7	hSpCas9	negative selection	7498481
15197533	15197556	19	+	27260156	MEWO	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.6159965532210041	[516]	[784,784,661]	9	hSpCas9	negative selection	7498482
15192396	15192419	19	-	27260156	MEWO	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	-0.023031123890541294	[898]	[933,960,607]	0	hSpCas9	negative selection	7562737
15197539	15197562	19	-	27260156	MEWO	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.24374034576150216	[180]	[147,137,143]	-5	hSpCas9	negative selection	7562738
15200826	15200849	19	+	27260156	MEWO	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	0.0006775427834719849	[12]	[19,15,1]	0	hSpCas9	negative selection	7562739
15200851	15200874	19	+	27260156	LNCAPCLONEFGC	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.5976478095022414	[272]	[176,104,141,229]	-7	hSpCas9	negative selection	7619731
15192393	15192416	19	+	27260156	LNCAPCLONEFGC	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.21470693971393917	[44]	[29,110,24,15]	3	hSpCas9	negative selection	7619732
15197533	15197556	19	+	27260156	LNCAPCLONEFGC	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.5844466523924269	[516]	[659,741,845,579]	8	hSpCas9	negative selection	7619733
15192396	15192419	19	-	27260156	LNCAPCLONEFGC	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.31541598845027496	[898]	[809,876,1297,1122]	5	hSpCas9	negative selection	7683988
15197539	15197562	19	-	27260156	LNCAPCLONEFGC	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.1456335185545501	[180]	[122,95,257,135]	-2	hSpCas9	negative selection	7683989
15200826	15200849	19	+	27260156	LNCAPCLONEFGC	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	0.43914858134984236	[12]	[10,2,23,27]	7	hSpCas9	negative selection	7683990
15200851	15200874	19	+	27260156	PANC0327	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.5332044756290409	[272]	[172,204,207,79]	-6	hSpCas9	negative selection	7740982
15192393	15192416	19	+	27260156	PANC0327	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.959669160354093	[44]	[60,8,6,9]	-8	hSpCas9	negative selection	7740983
15197533	15197556	19	+	27260156	PANC0327	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.45980246824250603	[516]	[623,687,420,784]	6	hSpCas9	negative selection	7740984
15192396	15192419	19	-	27260156	PANC0327	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.14009511381737227	[898]	[800,715,1147,869]	2	hSpCas9	negative selection	7805239
15197539	15197562	19	-	27260156	PANC0327	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.2273061513398753	[180]	[119,92,305,34]	-3	hSpCas9	negative selection	7805240
15200826	15200849	19	+	27260156	PANC0327	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	0.7861053152764796	[12]	[45,2,30,3]	9	hSpCas9	negative selection	7805241
15200851	15200874	19	+	27260156	NCIH2009	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.18806742658099762	[272]	[557,332,156]	-3	hSpCas9	negative selection	7862233
15192393	15192416	19	+	27260156	NCIH2009	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.9391038317771288	[44]	[44,17,37]	-8	hSpCas9	negative selection	7862234
15197533	15197556	19	+	27260156	NCIH2009	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	1.0072220632668278	[516]	[1636,1057,1701]	9	hSpCas9	negative selection	7862235
15192396	15192419	19	-	27260156	NCIH2009	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.32271912975134587	[898]	[1680,1506,1544]	4	hSpCas9	negative selection	7926490
15197539	15197562	19	-	27260156	NCIH2009	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	0.027448179447536525	[180]	[326,173,286]	0	hSpCas9	negative selection	7926491
15200826	15200849	19	+	27260156	NCIH2009	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	0.6579756864156403	[12]	[62,12,16]	8	hSpCas9	negative selection	7926492
15200851	15200874	19	+	27260156	NCIH1373	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.5441806619171649	[272]	[219,240,89,76]	-5	hSpCas9	negative selection	7983484
15192393	15192416	19	+	27260156	NCIH1373	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-1.2670593028990598	[44]	[3,50,10,2]	-8	hSpCas9	negative selection	7983485
15197533	15197556	19	+	27260156	NCIH1373	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.889625725054742	[516]	[1255,1058,1293,178]	8	hSpCas9	negative selection	7983486
15192396	15192419	19	-	27260156	NCIH1373	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.6424370821887	[898]	[1616,1226,1568,508]	6	hSpCas9	negative selection	8047741
15197539	15197562	19	-	27260156	NCIH1373	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.33423134418979394	[180]	[420,51,102,30]	-3	hSpCas9	negative selection	8047742
15200826	15200849	19	+	27260156	NCIH1373	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	-0.6971244716473874	[12]	[1,25,0,0]	-6	hSpCas9	negative selection	8047743
15200851	15200874	19	+	27260156	PATU8902	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-1.014704343030099	[272]	[208,48,204,295]	-7	hSpCas9	negative selection	8104735
15192393	15192416	19	+	27260156	PATU8902	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.3541628995982813	[44]	[19,20,124,4]	-4	hSpCas9	negative selection	8104736
15197533	15197556	19	+	27260156	PATU8902	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.6800791152648895	[516]	[1121,1033,1168,1292]	7	hSpCas9	negative selection	8104737
15192396	15192419	19	-	27260156	PATU8902	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	-0.21448470969124345	[898]	[1419,1050,581,1419]	-2	hSpCas9	negative selection	8168992
15197539	15197562	19	-	27260156	PATU8902	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-1.0325195968642407	[180]	[176,117,28,200]	-7	hSpCas9	negative selection	8168993
15200826	15200849	19	+	27260156	PATU8902	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	0.38765380393051085	[12]	[91,0,0,2]	4	hSpCas9	negative selection	8168994
15200851	15200874	19	+	27260156	PANC1	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.3211845306281441	[272]	[92,293,278,117]	-5	hSpCas9	negative selection	8225986
15192393	15192416	19	+	27260156	PANC1	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.779973957652619	[44]	[22,4,27,28]	-8	hSpCas9	negative selection	8225987
15197533	15197556	19	+	27260156	PANC1	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.5394876817817243	[516]	[618,724,628,618]	8	hSpCas9	negative selection	8225988
15192396	15192419	19	-	27260156	PANC1	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	-0.2663949103453559	[898]	[517,1053,615,482]	-4	hSpCas9	negative selection	8290243
15197539	15197562	19	-	27260156	PANC1	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	0.19843876425878149	[180]	[160,160,242,147]	3	hSpCas9	negative selection	8290244
15200826	15200849	19	+	27260156	PANC1	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	0.13590167670030873	[12]	[1,13,30,3]	2	hSpCas9	negative selection	8290245
15200851	15200874	19	+	27260156	PANC0813	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.2056057836401156	[272]	[299,226,341,246]	-3	hSpCas9	negative selection	8347237
15192393	15192416	19	+	27260156	PANC0813	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-1.3873694681344229	[44]	[16,22,28,11]	-9	hSpCas9	negative selection	8347238
15197533	15197556	19	+	27260156	PANC0813	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.7543887795395608	[516]	[1113,745,1023,1209]	9	hSpCas9	negative selection	8347239
15192396	15192419	19	-	27260156	PANC0813	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.17493757972210178	[898]	[1220,1390,980,1175]	3	hSpCas9	negative selection	8411494
15197539	15197562	19	-	27260156	PANC0813	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.2798258326074119	[180]	[192,196,210,104]	-4	hSpCas9	negative selection	8411495
15200826	15200849	19	+	27260156	PANC0813	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	-2.217905691757611	[12]	[2,1,2,4]	-9	hSpCas9	negative selection	8411496
15200851	15200874	19	+	27260156	RDES	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.944233723381981	[272]	[114,149,171,233]	-9	hSpCas9	negative selection	8468488
15192393	15192416	19	+	27260156	RDES	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.09032345992153523	[44]	[37,23,94,72]	1	hSpCas9	negative selection	8468489
15197533	15197556	19	+	27260156	RDES	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.7848651338169945	[516]	[697,1178,1092,1179]	9	hSpCas9	negative selection	8468490
15192396	15192419	19	-	27260156	RDES	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.2285502825668584	[898]	[807,1345,1248,1532]	3	hSpCas9	negative selection	8532745
15197539	15197562	19	-	27260156	RDES	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.09204151235167735	[180]	[170,167,206,244]	-1	hSpCas9	negative selection	8532746
15200826	15200849	19	+	27260156	RDES	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	-0.20221612367231945	[12]	[17,16,4,8]	-3	hSpCas9	negative selection	8532747
15200851	15200874	19	+	27260156	PC3	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.38292530666454805	[272]	[100,129,563,214]	-7	hSpCas9	negative selection	8589739
15192393	15192416	19	+	27260156	PC3	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-2.5192097764339256	[44]	[3,9,6,10]	-9	hSpCas9	negative selection	8589740
15197533	15197556	19	+	27260156	PC3	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.670695006559611	[516]	[585,794,1037,966]	9	hSpCas9	negative selection	8589741
15192396	15192419	19	-	27260156	PC3	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.09598258707416951	[898]	[638,712,1719,1119]	2	hSpCas9	negative selection	8653996
15197539	15197562	19	-	27260156	PC3	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.13857498666935997	[180]	[57,227,363,113]	-3	hSpCas9	negative selection	8653997
15200826	15200849	19	+	27260156	PC3	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	0.5019053501561421	[12]	[12,20,43,4]	8	hSpCas9	negative selection	8653998
15200851	15200874	19	+	27260156	PATU8988T	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.4053158685037327	[272]	[248,283,165,97]	-6	hSpCas9	negative selection	8710990
15192393	15192416	19	+	27260156	PATU8988T	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.0837887847379899	[44]	[31,18,75,33]	-1	hSpCas9	negative selection	8710991
15197533	15197556	19	+	27260156	PATU8988T	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.47164679618227723	[516]	[821,791,458,711]	7	hSpCas9	negative selection	8710992
15192396	15192419	19	-	27260156	PATU8988T	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.1411669423975459	[898]	[1179,991,859,790]	2	hSpCas9	negative selection	8775247
15197539	15197562	19	-	27260156	PATU8988T	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.37673825116960424	[180]	[42,183,207,104]	-6	hSpCas9	negative selection	8775248
15200826	15200849	19	+	27260156	PATU8988T	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	-0.3368637239481602	[12]	[1,1,32,0]	-5	hSpCas9	negative selection	8775249
15200851	15200874	19	+	27260156	T47D	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.06520551163319821	[272]	[307,293,302,311]	-1	hSpCas9	negative selection	8832241
15192393	15192416	19	+	27260156	T47D	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.03334010087849659	[44]	[60,55,34,62]	0	hSpCas9	negative selection	8832242
15197533	15197556	19	+	27260156	T47D	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.5701602836375633	[516]	[851,834,915,980]	9	hSpCas9	negative selection	8832243
15192396	15192419	19	-	27260156	T47D	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.08413953581057654	[898]	[1095,1078,1124,1143]	1	hSpCas9	negative selection	8896498
15197539	15197562	19	-	27260156	T47D	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.05360393244371253	[180]	[200,198,206,205]	-1	hSpCas9	negative selection	8896499
15200826	15200849	19	+	27260156	T47D	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	-0.5704055003995947	[12]	[10,5,15,7]	-8	hSpCas9	negative selection	8896500
15200851	15200874	19	+	27260156	SU8686	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.2848554378004108	[272]	[165,268,214,239]	-5	hSpCas9	negative selection	8953492
15192393	15192416	19	+	27260156	SU8686	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.13702219179010378	[44]	[32,56,50,15]	-2	hSpCas9	negative selection	8953493
15197533	15197556	19	+	27260156	SU8686	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.7542036919675955	[516]	[788,696,976,1052]	9	hSpCas9	negative selection	8953494
15192396	15192419	19	-	27260156	SU8686	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	-0.006265538291928219	[898]	[822,829,987,925]	0	hSpCas9	negative selection	9017749
15197539	15197562	19	-	27260156	SU8686	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.1165731066753386	[180]	[182,127,189,162]	-2	hSpCas9	negative selection	9017750
15200826	15200849	19	+	27260156	SU8686	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	0.3422053179043756	[12]	[5,13,43,0]	6	hSpCas9	negative selection	9017751
15200851	15200874	19	+	27260156	SKES1	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.4439826300295405	[272]	[123,213,260,190]	-7	hSpCas9	negative selection	9074743
15192393	15192416	19	+	27260156	SKES1	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.47709344499952566	[44]	[10,38,29,44]	-8	hSpCas9	negative selection	9074744
15197533	15197556	19	+	27260156	SKES1	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.466063534507713	[516]	[882,744,666,589]	8	hSpCas9	negative selection	9074745
15192396	15192419	19	-	27260156	SKES1	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.061781081741154376	[898]	[1070,1157,911,670]	1	hSpCas9	negative selection	9139000
15197539	15197562	19	-	27260156	SKES1	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.4269684447713751	[180]	[96,147,131,152]	-7	hSpCas9	negative selection	9139001
15200826	15200849	19	+	27260156	SKES1	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	-0.28163663929118865	[12]	[7,25,7,2]	-6	hSpCas9	negative selection	9139002
15200851	15200874	19	+	27260156	TOV112D	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.14798994342871552	[272]	[372,291,153,190]	-3	hSpCas9	negative selection	9195994
15192393	15192416	19	+	27260156	TOV112D	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.5749693711732111	[44]	[1,21,41,49]	-8	hSpCas9	negative selection	9195995
15197533	15197556	19	+	27260156	TOV112D	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.6645162902699105	[516]	[898,865,774,760]	9	hSpCas9	negative selection	9195996
15192396	15192419	19	-	27260156	TOV112D	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.0866115007703323	[898]	[1045,1125,1098,610]	1	hSpCas9	negative selection	9260251
15197539	15197562	19	-	27260156	TOV112D	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.48516137633738365	[180]	[181,161,47,137]	-7	hSpCas9	negative selection	9260252
15200826	15200849	19	+	27260156	TOV112D	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	-1.6657935537987907	[12]	[1,14,0,0]	-9	hSpCas9	negative selection	9260253
15200851	15200874	19	+	27260156	TC71	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.5214986349035448	[272]	[244,170,222,172]	-8	hSpCas9	negative selection	9317245
15192393	15192416	19	+	27260156	TC71	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.20950009367158584	[44]	[87,38,48,45]	5	hSpCas9	negative selection	9317246
15197533	15197556	19	+	27260156	TC71	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.417921209610864	[516]	[797,892,604,663]	8	hSpCas9	negative selection	9317247
15192396	15192419	19	-	27260156	TC71	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.05389477425660261	[898]	[1080,1179,774,968]	1	hSpCas9	negative selection	9381502
15197539	15197562	19	-	27260156	TC71	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.027272617041870006	[180]	[200,173,186,199]	0	hSpCas9	negative selection	9381503
15200826	15200849	19	+	27260156	TC71	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	-0.0826744469063172	[12]	[5,12,15,17]	-2	hSpCas9	negative selection	9381504
15200851	15200874	19	+	27260156	TC32	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	0.08774479068572372	[272]	[378,96,307,354]	1	hSpCas9	negative selection	9438496
15192393	15192416	19	+	27260156	TC32	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.5497209157436038	[44]	[10,32,34,36]	-8	hSpCas9	negative selection	9438497
15197533	15197556	19	+	27260156	TC32	viability	CAACGACCTCCATTTGCACACGG	NOTCH3	ENSG00000074181	0.5942495266146968	[516]	[679,565,800,935]	8	hSpCas9	negative selection	9438498
15192396	15192419	19	-	27260156	TC32	viability	GCACCGCCCGATTCTCATGCCGG	NOTCH3	ENSG00000074181	0.2469251865295572	[898]	[1084,728,1066,1181]	4	hSpCas9	negative selection	9502753
15197539	15197562	19	-	27260156	TC32	viability	GGAAGCCCGTGTGCAAATGGAGG	NOTCH3	ENSG00000074181	-0.2448728373646114	[180]	[121,89,202,186]	-4	hSpCas9	negative selection	9502754
15200826	15200849	19	+	27260156	TC32	viability	AGCGCCCGCACGGGTGGCGGTGG	NOTCH3	ENSG00000074181	0.7740943125876445	[12]	[50,0,8,22]	9	hSpCas9	negative selection	9502755
15191597	15191620	19	-	27869803	HPAFII	viability after 27 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	-0.11991653947041353	[319]	[108,192,NaN]	-1	hSpCas9	negative selection	9566052
15191744	15191767	19	-	27869803	HPAFII	viability after 27 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	-0.017899976800766604	[811]	[395,442,NaN]	0	hSpCas9	negative selection	9566053
15192146	15192169	19	-	27869803	HPAFII	viability after 27 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	0.1837875887043952	[275]	[202,132,NaN]	1	hSpCas9	negative selection	9566054
15192370	15192393	19	+	27869803	HPAFII	viability after 27 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	0.16342852709768896	[473]	[247,304,NaN]	1	hSpCas9	negative selection	9566055
15197551	15197574	19	+	27869803	HPAFII	viability after 27 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.4492708255327167	[624]	[782,169,NaN]	3	hSpCas9	negative selection	9566056
15200801	15200824	19	-	27869803	HPAFII	viability after 27 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	0.9258593744926287	[304]	[434,195,NaN]	7	hSpCas9	negative selection	9566057
15191597	15191620	19	-	27869803	HPAFII	viability after 15 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	0.2037052507005624	[319]	[593,272,NaN]	2	hSpCas9	negative selection	9648501
15191744	15191767	19	-	27869803	HPAFII	viability after 15 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	-0.297620626443176	[811]	[783,663,NaN]	-3	hSpCas9	negative selection	9648502
15192146	15192169	19	-	27869803	HPAFII	viability after 15 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	0.3121087295456455	[275]	[543,258,NaN]	3	hSpCas9	negative selection	9648503
15192370	15192393	19	+	27869803	HPAFII	viability after 15 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	-0.3169287763739317	[473]	[432,393,NaN]	-4	hSpCas9	negative selection	9648504
15197551	15197574	19	+	27869803	HPAFII	viability after 15 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.47104377788990415	[624]	[1559,539,NaN]	5	hSpCas9	negative selection	9648505
15200801	15200824	19	-	27869803	HPAFII	viability after 15 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	0.7876987489412963	[304]	[822,405,NaN]	8	hSpCas9	negative selection	9648506
15191597	15191620	19	-	27869803	ASPC1	viability after 36 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	0.8728649342870856	[887]	[844,558,373]	8	hSpCas9	negative selection	9730950
15191744	15191767	19	-	27869803	ASPC1	viability after 36 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	0.2964614062353974	[1557]	[992,799,327]	3	hSpCas9	negative selection	9730951
15192146	15192169	19	-	27869803	ASPC1	viability after 36 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	0.18992640238474057	[685]	[585,54,223]	1	hSpCas9	negative selection	9730952
15192370	15192393	19	+	27869803	ASPC1	viability after 36 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	-0.03839400920131897	[951]	[138,622,211]	0	hSpCas9	negative selection	9730953
15197551	15197574	19	+	27869803	ASPC1	viability after 36 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.7398775608763295	[1756]	[762,989,1223]	7	hSpCas9	negative selection	9730954
15200801	15200824	19	-	27869803	ASPC1	viability after 36 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	-0.20308439600155148	[856]	[203,350,223]	-2	hSpCas9	negative selection	9730955
15191597	15191620	19	-	27869803	PATU8988S	viability after 35 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	0.3177439608657587	[744]	[581,164,NaN]	3	hSpCas9	negative selection	9813399
15191744	15191767	19	-	27869803	PATU8988S	viability after 35 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	-0.23504270926343707	[1777]	[578,637,NaN]	-2	hSpCas9	negative selection	9813400
15192146	15192169	19	-	27869803	PATU8988S	viability after 35 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	0.6995814440926313	[474]	[392,227,NaN]	7	hSpCas9	negative selection	9813401
15192370	15192393	19	+	27869803	PATU8988S	viability after 35 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	-0.2224381696214286	[980]	[401,274,NaN]	-2	hSpCas9	negative selection	9813402
15197551	15197574	19	+	27869803	PATU8988S	viability after 35 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.5677546611511419	[1413]	[889,797,NaN]	6	hSpCas9	negative selection	9813403
15200801	15200824	19	-	27869803	PATU8988S	viability after 35 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	0.2893668375237621	[701]	[356,333,NaN]	3	hSpCas9	negative selection	9813404
15191597	15191620	19	-	27869803	PATU8988S	viability after 31 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	0.17927415347750758	[744]	[382,276,NaN]	2	hSpCas9	negative selection	9895848
15191744	15191767	19	-	27869803	PATU8988S	viability after 31 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	-0.21987039090931715	[1777]	[551,680,NaN]	-3	hSpCas9	negative selection	9895849
15192146	15192169	19	-	27869803	PATU8988S	viability after 31 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	0.5795035588866162	[474]	[242,333,NaN]	7	hSpCas9	negative selection	9895850
15192370	15192393	19	+	27869803	PATU8988S	viability after 31 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	-0.16341577155758746	[980]	[332,369,NaN]	-2	hSpCas9	negative selection	9895851
15197551	15197574	19	+	27869803	PATU8988S	viability after 31 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.7365613422021469	[1413]	[755,1172,NaN]	8	hSpCas9	negative selection	9895852
15200801	15200824	19	-	27869803	PATU8988S	viability after 31 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	0.45896212600584013	[701]	[393,372,NaN]	5	hSpCas9	negative selection	9895853
15191597	15191620	19	-	27869803	HPAFII	viability after 35 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	-0.1875647213270687	[319]	[50,244,NaN]	-1	hSpCas9	negative selection	9978297
15191744	15191767	19	-	27869803	HPAFII	viability after 35 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	0.11356817158576549	[811]	[273,636,NaN]	0	hSpCas9	negative selection	9978298
15192146	15192169	19	-	27869803	HPAFII	viability after 35 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	0.6647398568423764	[275]	[284,149,NaN]	4	hSpCas9	negative selection	9978299
15192370	15192393	19	+	27869803	HPAFII	viability after 35 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	-0.1666540121379818	[473]	[130,306,NaN]	-1	hSpCas9	negative selection	9978300
15197551	15197574	19	+	27869803	HPAFII	viability after 35 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.5995907299879053	[624]	[779,140,NaN]	4	hSpCas9	negative selection	9978301
15200801	15200824	19	-	27869803	HPAFII	viability after 35 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	0.44173941083180057	[304]	[236,178,NaN]	3	hSpCas9	negative selection	9978302
15191597	15191620	19	-	27869803	HPAFII	viability after 31 days	CAGCCCAACGCCTGCCACAATGG	NOTCH3	ENSG00000074181	-0.06992117459709507	[319]	[94,253,NaN]	0	hSpCas9	negative selection	10060746
15191744	15191767	19	-	27869803	HPAFII	viability after 31 days	CAGTGCCCTCCTGAGTGGACAGG	NOTCH3	ENSG00000074181	0.2416795740968245	[811]	[422,664,NaN]	1	hSpCas9	negative selection	10060747
15192146	15192169	19	-	27869803	HPAFII	viability after 31 days	CGACGTGGATGAGTGCCGGGTGG	NOTCH3	ENSG00000074181	0.4150942076229733	[275]	[251,156,NaN]	3	hSpCas9	negative selection	10060748
15192370	15192393	19	+	27869803	HPAFII	viability after 31 days	CTCTCACCTCGGAAGCCACGGGG	NOTCH3	ENSG00000074181	-0.03864333874714021	[473]	[213,307,NaN]	0	hSpCas9	negative selection	10060749
15197551	15197574	19	+	27869803	HPAFII	viability after 31 days	CACGGGCTTCCGTCCAGGCAAGG	NOTCH3	ENSG00000074181	0.32084578867391755	[624]	[719,130,NaN]	2	hSpCas9	negative selection	10060750
15200801	15200824	19	-	27869803	HPAFII	viability after 31 days	CCCTGCTGCTGCTGCTAGCGGGG	NOTCH3	ENSG00000074181	0.5338628965247517	[304]	[254,239,NaN]	4	hSpCas9	negative selection	10060751
15185295	15185318	19	-	28162770	P31FUJ	viability	GGTGGGACATGCAGCAGCGATGG	NOTCH3	ENSG00000074181	-2.2328022044143783	[15]	[3]	-8	hSpCas9	negative selection	10201493
15187195	15187218	19	-	28162770	P31FUJ	viability	CACACGCTGCGAGAGCCAGGTGG	NOTCH3	ENSG00000074181	0.33330126905546154	[76]	[113]	3	hSpCas9	negative selection	10201494
15200851	15200874	19	+	28162770	P31FUJ	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	0.6052792332754886	[145]	[260]	7	hSpCas9	negative selection	10201495
15192438	15192461	19	+	28162770	P31FUJ	viability	GCAGACACCACGGCCAGCACAGG	NOTCH3	ENSG00000074181	0.39522901819866346	[153]	[237]	4	hSpCas9	negative selection	10201496
15192393	15192416	19	+	28162770	P31FUJ	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.019584957219906718	[135]	[161]	0	hSpCas9	negative selection	10201497
15192221	15192244	19	+	28162770	P31FUJ	viability	CATCGGGCCCCACTGAGCAGCGG	NOTCH3	ENSG00000074181	0.4007041482648147	[262]	[407]	4	hSpCas9	negative selection	10201498
15192145	15192168	19	-	28162770	P31FUJ	viability	GACGTGGATGAGTGCCGGGTGGG	NOTCH3	ENSG00000074181	0.053911197888925955	[140]	[171]	0	hSpCas9	negative selection	10201499
15192044	15192067	19	-	28162770	P31FUJ	viability	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	0.09126163481697486	[269]	[337]	0	hSpCas9	negative selection	10201500
15192029	15192052	19	+	28162770	P31FUJ	viability	AGGGTGCACAGGGCACCGCGGGG	NOTCH3	ENSG00000074181	0.8564651336827088	[140]	[299]	8	hSpCas9	negative selection	10201501
15187893	15187916	19	+	28162770	P31FUJ	viability	GGCACTCGTAGCCATCGGGCTGG	NOTCH3	ENSG00000074181	-0.008537368745160232	[219]	[256]	0	hSpCas9	negative selection	10201502
15185295	15185318	19	-	28162770	TF1	viability	GGTGGGACATGCAGCAGCGATGG	NOTCH3	ENSG00000074181	NaN	[NaN]	[37]	1	hSpCas9	negative selection	10370859
15187195	15187218	19	-	28162770	TF1	viability	CACACGCTGCGAGAGCCAGGTGG	NOTCH3	ENSG00000074181	NaN	[NaN]	[53]	1	hSpCas9	negative selection	10370860
15200851	15200874	19	+	28162770	TF1	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	NaN	[NaN]	[299]	1	hSpCas9	negative selection	10370861
15192438	15192461	19	+	28162770	TF1	viability	GCAGACACCACGGCCAGCACAGG	NOTCH3	ENSG00000074181	NaN	[NaN]	[150]	1	hSpCas9	negative selection	10370862
15192393	15192416	19	+	28162770	TF1	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	NaN	[NaN]	[148]	1	hSpCas9	negative selection	10370863
15192221	15192244	19	+	28162770	TF1	viability	CATCGGGCCCCACTGAGCAGCGG	NOTCH3	ENSG00000074181	NaN	[NaN]	[178]	1	hSpCas9	negative selection	10370864
15192145	15192168	19	-	28162770	TF1	viability	GACGTGGATGAGTGCCGGGTGGG	NOTCH3	ENSG00000074181	NaN	[NaN]	[62]	1	hSpCas9	negative selection	10370865
15192044	15192067	19	-	28162770	TF1	viability	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	NaN	[NaN]	[256]	1	hSpCas9	negative selection	10370866
15192029	15192052	19	+	28162770	TF1	viability	AGGGTGCACAGGGCACCGCGGGG	NOTCH3	ENSG00000074181	NaN	[NaN]	[155]	1	hSpCas9	negative selection	10370867
15187893	15187916	19	+	28162770	TF1	viability	GGCACTCGTAGCCATCGGGCTGG	NOTCH3	ENSG00000074181	NaN	[NaN]	[254]	1	hSpCas9	negative selection	10370868
15185295	15185318	19	-	28162770	SKM1	viability	GGTGGGACATGCAGCAGCGATGG	NOTCH3	ENSG00000074181	-0.8220016980220057	[6]	[6]	-6	hSpCas9	negative selection	10540225
15187195	15187218	19	-	28162770	SKM1	viability	CACACGCTGCGAGAGCCAGGTGG	NOTCH3	ENSG00000074181	0.8300749985576876	[13]	[43]	7	hSpCas9	negative selection	10540226
15200851	15200874	19	+	28162770	SKM1	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.7425672305276005	[52]	[55]	-5	hSpCas9	negative selection	10540227
15192438	15192461	19	+	28162770	SKM1	viability	GCAGACACCACGGCCAGCACAGG	NOTCH3	ENSG00000074181	-0.06016143521677003	[45]	[77]	0	hSpCas9	negative selection	10540228
15192393	15192416	19	+	28162770	SKM1	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.029899662988860765	[40]	[73]	0	hSpCas9	negative selection	10540229
15192221	15192244	19	+	28162770	SKM1	viability	CATCGGGCCCCACTGAGCAGCGG	NOTCH3	ENSG00000074181	-0.0850361038557993	[98]	[164]	0	hSpCas9	negative selection	10540230
15192145	15192168	19	-	28162770	SKM1	viability	GACGTGGATGAGTGCCGGGTGGG	NOTCH3	ENSG00000074181	-0.14822993034299337	[41]	[66]	-1	hSpCas9	negative selection	10540231
15192044	15192067	19	-	28162770	SKM1	viability	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	0.8189172086731661	[58]	[183]	7	hSpCas9	negative selection	10540232
15192029	15192052	19	+	28162770	SKM1	viability	AGGGTGCACAGGGCACCGCGGGG	NOTCH3	ENSG00000074181	-0.6844981742720707	[29]	[32]	-5	hSpCas9	negative selection	10540233
15187893	15187916	19	+	28162770	SKM1	viability	GGCACTCGTAGCCATCGGGCTGG	NOTCH3	ENSG00000074181	1.0204570249915146	[57]	[207]	8	hSpCas9	negative selection	10540234
15185295	15185318	19	-	28162770	SKM1	viability	GGTGGGACATGCAGCAGCGATGG	NOTCH3	ENSG00000074181	-0.8220016980220057	[6]	[6]	-6	hSpCas9	negative selection	10709591
15187195	15187218	19	-	28162770	SKM1	viability	CACACGCTGCGAGAGCCAGGTGG	NOTCH3	ENSG00000074181	0.8300749985576876	[13]	[43]	7	hSpCas9	negative selection	10709592
15200851	15200874	19	+	28162770	SKM1	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.7425672305276005	[52]	[55]	-5	hSpCas9	negative selection	10709593
15192438	15192461	19	+	28162770	SKM1	viability	GCAGACACCACGGCCAGCACAGG	NOTCH3	ENSG00000074181	-0.06016143521677003	[45]	[77]	0	hSpCas9	negative selection	10709594
15192393	15192416	19	+	28162770	SKM1	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.029899662988860765	[40]	[73]	0	hSpCas9	negative selection	10709595
15192221	15192244	19	+	28162770	SKM1	viability	CATCGGGCCCCACTGAGCAGCGG	NOTCH3	ENSG00000074181	-0.0850361038557993	[98]	[164]	0	hSpCas9	negative selection	10709596
15192145	15192168	19	-	28162770	SKM1	viability	GACGTGGATGAGTGCCGGGTGGG	NOTCH3	ENSG00000074181	-0.14822993034299337	[41]	[66]	-1	hSpCas9	negative selection	10709597
15192044	15192067	19	-	28162770	SKM1	viability	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	0.8189172086731661	[58]	[183]	7	hSpCas9	negative selection	10709598
15192029	15192052	19	+	28162770	SKM1	viability	AGGGTGCACAGGGCACCGCGGGG	NOTCH3	ENSG00000074181	-0.6844981742720707	[29]	[32]	-5	hSpCas9	negative selection	10709599
15187893	15187916	19	+	28162770	SKM1	viability	GGCACTCGTAGCCATCGGGCTGG	NOTCH3	ENSG00000074181	1.0204570249915146	[57]	[207]	8	hSpCas9	negative selection	10709600
15185295	15185318	19	-	28162770	PL21	viability	GGTGGGACATGCAGCAGCGATGG	NOTCH3	ENSG00000074181	-2.5547478876741487	[26]	[1]	-9	hSpCas9	negative selection	10878957
15187195	15187218	19	-	28162770	PL21	viability	CACACGCTGCGAGAGCCAGGTGG	NOTCH3	ENSG00000074181	0.661273528357618	[76]	[52]	6	hSpCas9	negative selection	10878958
15200851	15200874	19	+	28162770	PL21	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	0.1924860419458848	[188]	[93]	1	hSpCas9	negative selection	10878959
15192438	15192461	19	+	28162770	PL21	viability	GCAGACACCACGGCCAGCACAGG	NOTCH3	ENSG00000074181	-0.2446452281835759	[195]	[71]	-2	hSpCas9	negative selection	10878960
15192393	15192416	19	+	28162770	PL21	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.637825852713364	[157]	[106]	5	hSpCas9	negative selection	10878961
15192221	15192244	19	+	28162770	PL21	viability	CATCGGGCCCCACTGAGCAGCGG	NOTCH3	ENSG00000074181	0.809056847362199	[218]	[166]	7	hSpCas9	negative selection	10878962
15192145	15192168	19	-	28162770	PL21	viability	GACGTGGATGAGTGCCGGGTGGG	NOTCH3	ENSG00000074181	0.7790019156740584	[78]	[58]	6	hSpCas9	negative selection	10878963
15192044	15192067	19	-	28162770	PL21	viability	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	-0.6956715352387086	[226]	[60]	-5	hSpCas9	negative selection	10878964
15192029	15192052	19	+	28162770	PL21	viability	AGGGTGCACAGGGCACCGCGGGG	NOTCH3	ENSG00000074181	0.8911893736001679	[82]	[66]	7	hSpCas9	negative selection	10878965
15187893	15187916	19	+	28162770	PL21	viability	GGCACTCGTAGCCATCGGGCTGG	NOTCH3	ENSG00000074181	-0.4286771758212634	[166]	[53]	-3	hSpCas9	negative selection	10878966
15185295	15185318	19	-	28162770	P31FUJ	viability	GGTGGGACATGCAGCAGCGATGG	NOTCH3	ENSG00000074181	-2.2328022044143783	[15]	[3]	-8	hSpCas9	negative selection	11048323
15187195	15187218	19	-	28162770	P31FUJ	viability	CACACGCTGCGAGAGCCAGGTGG	NOTCH3	ENSG00000074181	0.33330126905546154	[76]	[113]	3	hSpCas9	negative selection	11048324
15200851	15200874	19	+	28162770	P31FUJ	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	0.6052792332754886	[145]	[260]	7	hSpCas9	negative selection	11048325
15192438	15192461	19	+	28162770	P31FUJ	viability	GCAGACACCACGGCCAGCACAGG	NOTCH3	ENSG00000074181	0.39522901819866346	[153]	[237]	4	hSpCas9	negative selection	11048326
15192393	15192416	19	+	28162770	P31FUJ	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.019584957219906718	[135]	[161]	0	hSpCas9	negative selection	11048327
15192221	15192244	19	+	28162770	P31FUJ	viability	CATCGGGCCCCACTGAGCAGCGG	NOTCH3	ENSG00000074181	0.4007041482648147	[262]	[407]	4	hSpCas9	negative selection	11048328
15192145	15192168	19	-	28162770	P31FUJ	viability	GACGTGGATGAGTGCCGGGTGGG	NOTCH3	ENSG00000074181	0.053911197888925955	[140]	[171]	0	hSpCas9	negative selection	11048329
15192044	15192067	19	-	28162770	P31FUJ	viability	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	0.09126163481697486	[269]	[337]	0	hSpCas9	negative selection	11048330
15192029	15192052	19	+	28162770	P31FUJ	viability	AGGGTGCACAGGGCACCGCGGGG	NOTCH3	ENSG00000074181	0.8564651336827088	[140]	[299]	8	hSpCas9	negative selection	11048331
15187893	15187916	19	+	28162770	P31FUJ	viability	GGCACTCGTAGCCATCGGGCTGG	NOTCH3	ENSG00000074181	-0.008537368745160232	[219]	[256]	0	hSpCas9	negative selection	11048332
15185295	15185318	19	-	28162770	OCIAML5	viability	GGTGGGACATGCAGCAGCGATGG	NOTCH3	ENSG00000074181	3.0059144242635756	[1]	[28]	9	hSpCas9	negative selection	11217689
15187195	15187218	19	-	28162770	OCIAML5	viability	CACACGCTGCGAGAGCCAGGTGG	NOTCH3	ENSG00000074181	-1.2671040701428409	[71]	[53]	-6	hSpCas9	negative selection	11217690
15200851	15200874	19	+	28162770	OCIAML5	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.5861725108909625	[83]	[100]	-4	hSpCas9	negative selection	11217691
15192438	15192461	19	+	28162770	OCIAML5	viability	GCAGACACCACGGCCAGCACAGG	NOTCH3	ENSG00000074181	-0.08975812858332755	[78]	[133]	0	hSpCas9	negative selection	11217692
15192393	15192416	19	+	28162770	OCIAML5	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.21463665024870515	[80]	[125]	-1	hSpCas9	negative selection	11217693
15192221	15192244	19	+	28162770	OCIAML5	viability	CATCGGGCCCCACTGAGCAGCGG	NOTCH3	ENSG00000074181	-0.05236522134982802	[161]	[281]	0	hSpCas9	negative selection	11217694
15192145	15192168	19	-	28162770	OCIAML5	viability	GACGTGGATGAGTGCCGGGTGGG	NOTCH3	ENSG00000074181	0.24104283352748457	[59]	[127]	2	hSpCas9	negative selection	11217695
15192044	15192067	19	-	28162770	OCIAML5	viability	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	0.3598525192429425	[157]	[365]	3	hSpCas9	negative selection	11217696
15192029	15192052	19	+	28162770	OCIAML5	viability	AGGGTGCACAGGGCACCGCGGGG	NOTCH3	ENSG00000074181	0.927164750279219	[36]	[126]	7	hSpCas9	negative selection	11217697
15187893	15187916	19	+	28162770	OCIAML5	viability	GGCACTCGTAGCCATCGGGCTGG	NOTCH3	ENSG00000074181	-0.16401057717873738	[143]	[231]	-1	hSpCas9	negative selection	11217698
15185295	15185318	19	-	28162770	EOL1	viability	GGTGGGACATGCAGCAGCGATGG	NOTCH3	ENSG00000074181	2.126181632740185	[29]	[68]	9	hSpCas9	negative selection	11387055
15187195	15187218	19	-	28162770	EOL1	viability	CACACGCTGCGAGAGCCAGGTGG	NOTCH3	ENSG00000074181	0.6350411543755494	[54]	[44]	5	hSpCas9	negative selection	11387056
15200851	15200874	19	+	28162770	EOL1	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	0.2814284652923215	[366]	[234]	2	hSpCas9	negative selection	11387057
15192438	15192461	19	+	28162770	EOL1	viability	GCAGACACCACGGCCAGCACAGG	NOTCH3	ENSG00000074181	-0.4278341198585417	[382]	[149]	-3	hSpCas9	negative selection	11387058
15192393	15192416	19	+	28162770	EOL1	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.42642885582732604	[300]	[117]	-3	hSpCas9	negative selection	11387059
15192221	15192244	19	+	28162770	EOL1	viability	CATCGGGCCCCACTGAGCAGCGG	NOTCH3	ENSG00000074181	-0.00950691660561287	[448]	[234]	0	hSpCas9	negative selection	11387060
15192145	15192168	19	-	28162770	EOL1	viability	GACGTGGATGAGTGCCGGGTGGG	NOTCH3	ENSG00000074181	-1.0229848085353301	[134]	[34]	-6	hSpCas9	negative selection	11387061
15192044	15192067	19	-	28162770	EOL1	viability	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	0.7799383908664282	[345]	[312]	7	hSpCas9	negative selection	11387062
15192029	15192052	19	+	28162770	EOL1	viability	AGGGTGCACAGGGCACCGCGGGG	NOTCH3	ENSG00000074181	0.5470736852481741	[138]	[106]	5	hSpCas9	negative selection	11387063
15187893	15187916	19	+	28162770	EOL1	viability	GGCACTCGTAGCCATCGGGCTGG	NOTCH3	ENSG00000074181	-0.5294087170006117	[262]	[95]	-4	hSpCas9	negative selection	11387064
15185295	15185318	19	-	28162770	MOLM13	viability	GGTGGGACATGCAGCAGCGATGG	NOTCH3	ENSG00000074181	-4.175966808230147	[24]	[0]	-9	hSpCas9	negative selection	11556421
15187195	15187218	19	-	28162770	MOLM13	viability	CACACGCTGCGAGAGCCAGGTGG	NOTCH3	ENSG00000074181	-2.0499589233180404	[125]	[21]	-7	hSpCas9	negative selection	11556422
15200851	15200874	19	+	28162770	MOLM13	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	0.8102126971830118	[294]	[373]	6	hSpCas9	negative selection	11556423
15192438	15192461	19	+	28162770	MOLM13	viability	GCAGACACCACGGCCAGCACAGG	NOTCH3	ENSG00000074181	-0.0500664306798317	[304]	[212]	0	hSpCas9	negative selection	11556424
15192393	15192416	19	+	28162770	MOLM13	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.29612303327809886	[195]	[173]	2	hSpCas9	negative selection	11556425
15192221	15192244	19	+	28162770	MOLM13	viability	CATCGGGCCCCACTGAGCAGCGG	NOTCH3	ENSG00000074181	0.8012430832297146	[326]	[411]	6	hSpCas9	negative selection	11556426
15192145	15192168	19	-	28162770	MOLM13	viability	GACGTGGATGAGTGCCGGGTGGG	NOTCH3	ENSG00000074181	1.9630972295074058	[104]	[295]	9	hSpCas9	negative selection	11556427
15192044	15192067	19	-	28162770	MOLM13	viability	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	-0.13656929480237454	[297]	[195]	-1	hSpCas9	negative selection	11556428
15192029	15192052	19	+	28162770	MOLM13	viability	AGGGTGCACAGGGCACCGCGGGG	NOTCH3	ENSG00000074181	1.3683537079936645	[74]	[139]	9	hSpCas9	negative selection	11556429
15187893	15187916	19	+	28162770	MOLM13	viability	GGCACTCGTAGCCATCGGGCTGG	NOTCH3	ENSG00000074181	-0.2556971828204273	[321]	[194]	-1	hSpCas9	negative selection	11556430
15185295	15185318	19	-	28162770	HEL	viability	GGTGGGACATGCAGCAGCGATGG	NOTCH3	ENSG00000074181	-2.527186169441955	[8]	[0]	-8	hSpCas9	negative selection	11725787
15187195	15187218	19	-	28162770	HEL	viability	CACACGCTGCGAGAGCCAGGTGG	NOTCH3	ENSG00000074181	-0.6898365070865138	[67]	[26]	-4	hSpCas9	negative selection	11725788
15200851	15200874	19	+	28162770	HEL	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	0.30804344103911685	[226]	[179]	2	hSpCas9	negative selection	11725789
15192438	15192461	19	+	28162770	HEL	viability	GCAGACACCACGGCCAGCACAGG	NOTCH3	ENSG00000074181	0.06331451482063075	[259]	[173]	0	hSpCas9	negative selection	11725790
15192393	15192416	19	+	28162770	HEL	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.09919301505919853	[193]	[115]	0	hSpCas9	negative selection	11725791
15192221	15192244	19	+	28162770	HEL	viability	CATCGGGCCCCACTGAGCAGCGG	NOTCH3	ENSG00000074181	0.6772665151286281	[288]	[295]	6	hSpCas9	negative selection	11725792
15192145	15192168	19	-	28162770	HEL	viability	GACGTGGATGAGTGCCGGGTGGG	NOTCH3	ENSG00000074181	-0.4478637167805499	[114]	[53]	-3	hSpCas9	negative selection	11725793
15192044	15192067	19	-	28162770	HEL	viability	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	-0.26885219377787767	[268]	[142]	-2	hSpCas9	negative selection	11725794
15192029	15192052	19	+	28162770	HEL	viability	AGGGTGCACAGGGCACCGCGGGG	NOTCH3	ENSG00000074181	0.033528785032523434	[89]	[58]	0	hSpCas9	negative selection	11725795
15187893	15187916	19	+	28162770	HEL	viability	GGCACTCGTAGCCATCGGGCTGG	NOTCH3	ENSG00000074181	-0.9313762864838069	[264]	[88]	-5	hSpCas9	negative selection	11725796
15185295	15185318	19	-	28162770	MV411	viability	GGTGGGACATGCAGCAGCGATGG	NOTCH3	ENSG00000074181	-2.255062789746408	[16]	[2]	-8	hSpCas9	negative selection	11895153
15187195	15187218	19	-	28162770	MV411	viability	CACACGCTGCGAGAGCCAGGTGG	NOTCH3	ENSG00000074181	0.4884456502865704	[54]	[64]	4	hSpCas9	negative selection	11895154
15200851	15200874	19	+	28162770	MV411	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	0.34221577553487526	[161]	[172]	3	hSpCas9	negative selection	11895155
15192438	15192461	19	+	28162770	MV411	viability	GCAGACACCACGGCCAGCACAGG	NOTCH3	ENSG00000074181	0.2406162849267613	[211]	[210]	2	hSpCas9	negative selection	11895156
15192393	15192416	19	+	28162770	MV411	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.9666872545700721	[173]	[74]	-6	hSpCas9	negative selection	11895157
15192221	15192244	19	+	28162770	MV411	viability	CATCGGGCCCCACTGAGCAGCGG	NOTCH3	ENSG00000074181	-0.44523876723863426	[277]	[171]	-3	hSpCas9	negative selection	11895158
15192145	15192168	19	-	28162770	MV411	viability	GACGTGGATGAGTGCCGGGTGGG	NOTCH3	ENSG00000074181	0.03444382744857688	[101]	[87]	0	hSpCas9	negative selection	11895159
15192044	15192067	19	-	28162770	MV411	viability	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	0.19804952382061197	[207]	[200]	1	hSpCas9	negative selection	11895160
15192029	15192052	19	+	28162770	MV411	viability	AGGGTGCACAGGGCACCGCGGGG	NOTCH3	ENSG00000074181	0.9350532285662839	[112]	[181]	8	hSpCas9	negative selection	11895161
15187893	15187916	19	+	28162770	MV411	viability	GGCACTCGTAGCCATCGGGCTGG	NOTCH3	ENSG00000074181	0.6649950420401345	[142]	[190]	6	hSpCas9	negative selection	11895162
15185295	15185318	19	-	28162770	MONOMAC1	viability	GGTGGGACATGCAGCAGCGATGG	NOTCH3	ENSG00000074181	-0.3225677291434126	[11]	[10]	-3	hSpCas9	negative selection	12064519
15187195	15187218	19	-	28162770	MONOMAC1	viability	CACACGCTGCGAGAGCCAGGTGG	NOTCH3	ENSG00000074181	0.8029631529404462	[36]	[73]	7	hSpCas9	negative selection	12064520
15200851	15200874	19	+	28162770	MONOMAC1	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	1.1282039818686445	[86]	[217]	8	hSpCas9	negative selection	12064521
15192438	15192461	19	+	28162770	MONOMAC1	viability	GCAGACACCACGGCCAGCACAGG	NOTCH3	ENSG00000074181	0.35045094824293965	[90]	[132]	3	hSpCas9	negative selection	12064522
15192393	15192416	19	+	28162770	MONOMAC1	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.5051591424218858	[103]	[83]	-4	hSpCas9	negative selection	12064523
15192221	15192244	19	+	28162770	MONOMAC1	viability	CATCGGGCCCCACTGAGCAGCGG	NOTCH3	ENSG00000074181	0.288389980110688	[144]	[202]	3	hSpCas9	negative selection	12064524
15192145	15192168	19	-	28162770	MONOMAC1	viability	GACGTGGATGAGTGCCGGGTGGG	NOTCH3	ENSG00000074181	0.6642568821088541	[59]	[108]	6	hSpCas9	negative selection	12064525
15192044	15192067	19	-	28162770	MONOMAC1	viability	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	-0.09090849619821029	[130]	[140]	-1	hSpCas9	negative selection	12064526
15192029	15192052	19	+	28162770	MONOMAC1	viability	AGGGTGCACAGGGCACCGCGGGG	NOTCH3	ENSG00000074181	0.5069783253053659	[61]	[100]	5	hSpCas9	negative selection	12064527
15187893	15187916	19	+	28162770	MONOMAC1	viability	GGCACTCGTAGCCATCGGGCTGG	NOTCH3	ENSG00000074181	-0.8566967150583111	[108]	[68]	-6	hSpCas9	negative selection	12064528
15185295	15185318	19	-	28162770	OCIAML2	viability	GGTGGGACATGCAGCAGCGATGG	NOTCH3	ENSG00000074181	-1.8856673245210054	[1]	[2]	-8	hSpCas9	negative selection	12233885
15187195	15187218	19	-	28162770	OCIAML2	viability	CACACGCTGCGAGAGCCAGGTGG	NOTCH3	ENSG00000074181	-0.3114312303929072	[14]	[66]	-3	hSpCas9	negative selection	12233886
15200851	15200874	19	+	28162770	OCIAML2	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	1.0863182993093983	[25]	[305]	9	hSpCas9	negative selection	12233887
15192438	15192461	19	+	28162770	OCIAML2	viability	GCAGACACCACGGCCAGCACAGG	NOTCH3	ENSG00000074181	0.22285713225716403	[31]	[206]	2	hSpCas9	negative selection	12233888
15192393	15192416	19	+	28162770	OCIAML2	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	-0.05072657079150152	[36]	[197]	0	hSpCas9	negative selection	12233889
15192221	15192244	19	+	28162770	OCIAML2	viability	CATCGGGCCCCACTGAGCAGCGG	NOTCH3	ENSG00000074181	0.5718622568719176	[45]	[378]	5	hSpCas9	negative selection	12233890
15192145	15192168	19	-	28162770	OCIAML2	viability	GACGTGGATGAGTGCCGGGTGGG	NOTCH3	ENSG00000074181	-0.567305844653835	[26]	[100]	-4	hSpCas9	negative selection	12233891
15192044	15192067	19	-	28162770	OCIAML2	viability	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	0.21828363951790328	[28]	[186]	2	hSpCas9	negative selection	12233892
15192029	15192052	19	+	28162770	OCIAML2	viability	AGGGTGCACAGGGCACCGCGGGG	NOTCH3	ENSG00000074181	0.6898348469510849	[16]	[151]	6	hSpCas9	negative selection	12233893
15187893	15187916	19	+	28162770	OCIAML2	viability	GGCACTCGTAGCCATCGGGCTGG	NOTCH3	ENSG00000074181	0.5066500982577552	[23]	[188]	5	hSpCas9	negative selection	12233894
15185295	15185318	19	-	28162770	OCIAML3	viability	GGTGGGACATGCAGCAGCGATGG	NOTCH3	ENSG00000074181	-1.5940076403241634	[5]	[5]	-8	hSpCas9	negative selection	12403251
15187195	15187218	19	-	28162770	OCIAML3	viability	CACACGCTGCGAGAGCCAGGTGG	NOTCH3	ENSG00000074181	-0.2500532391068018	[12]	[32]	-2	hSpCas9	negative selection	12403252
15200851	15200874	19	+	28162770	OCIAML3	viability	GTGGCGGCGACATCGGGCGACGG	NOTCH3	ENSG00000074181	-0.34439375025269103	[44]	[106]	-3	hSpCas9	negative selection	12403253
15192438	15192461	19	+	28162770	OCIAML3	viability	GCAGACACCACGGCCAGCACAGG	NOTCH3	ENSG00000074181	-0.12622867897334605	[46]	[129]	-1	hSpCas9	negative selection	12403254
15192393	15192416	19	+	28162770	OCIAML3	viability	GCACCGGCATGAGAATCGGGCGG	NOTCH3	ENSG00000074181	0.048098767500601936	[32]	[102]	0	hSpCas9	negative selection	12403255
15192221	15192244	19	+	28162770	OCIAML3	viability	CATCGGGCCCCACTGAGCAGCGG	NOTCH3	ENSG00000074181	1.2648162967151424	[58]	[427]	9	hSpCas9	negative selection	12403256
15192145	15192168	19	-	28162770	OCIAML3	viability	GACGTGGATGAGTGCCGGGTGGG	NOTCH3	ENSG00000074181	-0.062287160879986425	[45]	[132]	0	hSpCas9	negative selection	12403257
15192044	15192067	19	-	28162770	OCIAML3	viability	GCCACTATGTGAGAACCCCGCGG	NOTCH3	ENSG00000074181	0.5835305452280243	[41]	[189]	5	hSpCas9	negative selection	12403258
15192029	15192052	19	+	28162770	OCIAML3	viability	AGGGTGCACAGGGCACCGCGGGG	NOTCH3	ENSG00000074181	0.27106277958972824	[27]	[101]	2	hSpCas9	negative selection	12403259
15187893	15187916	19	+	28162770	OCIAML3	viability	GGCACTCGTAGCCATCGGGCTGG	NOTCH3	ENSG00000074181	-0.6971011332882666	[57]	[107]	-5	hSpCas9	negative selection	12403260