Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:4976
• Symbol:OPA1
• Description:OPA1 mitochondrial dynamin like GTPase

DataSource: http://genomecrispr.dkfz.de/#!/results/OPA1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
193657202	193657225	3	+	26472758	Jiyoye	viability	CAAGTGGAATGACTTTGCGGAGG	OPA1	ENSG00000198836	-0.8284528669872686	[72]	[30]	-5	hSpCas9	negative selection	113755
193638009	193638032	3	+	26472758	Jiyoye	viability	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-0.6971612783088621	[42]	[19]	-5	hSpCas9	negative selection	113756
193637259	193637282	3	+	26472758	Jiyoye	viability	ATACGCAAGATCATCTGCCACGG	OPA1	ENSG00000198836	-0.5128563137907114	[192]	[101]	-4	hSpCas9	negative selection	113757
193654952	193654975	3	+	26472758	Jiyoye	viability	AGGAACTTTTAACACCACAGTGG	OPA1	ENSG00000198836	4.407175381505873	[0]	[15]	9	hSpCas9	negative selection	113758
193659540	193659563	3	+	26472758	Jiyoye	viability	GAAGAATCGGACCCAAGAACAGG	OPA1	ENSG00000198836	-1.9284276502785658	[105]	[20]	-8	hSpCas9	negative selection	113759
193643389	193643412	3	+	26472758	Jiyoye	viability	TAAAAGGCCCTGGACTACAGAGG	OPA1	ENSG00000198836	-1.7679113250522178	[139]	[30]	-8	hSpCas9	negative selection	113760
193648116	193648139	3	-	26472758	Jiyoye	viability	TTACCCGGTCAAGTTCCCGCAGG	OPA1	ENSG00000198836	-0.3477121206575955	[26]	[15]	-2	hSpCas9	negative selection	113761
193666292	193666315	3	+	26472758	Jiyoye	viability	TCAGTTGGAATGCAATGATGTGG	OPA1	ENSG00000198836	0.16856444961129724	[163]	[138]	1	hSpCas9	negative selection	113762
193593383	193593406	3	+	26472758	Jiyoye	viability	GCGACTACGTCGGGCCGCTGTGG	OPA1	ENSG00000198836	4.2145303035634765	[0]	[13]	9	hSpCas9	negative selection	113763
193615724	193615747	3	+	26472758	Jiyoye	viability	GATTGTGCCTGACATTGTGTGGG	OPA1	ENSG00000198836	-1.165076067465729	[338]	[113]	-7	hSpCas9	negative selection	113764
193657202	193657225	3	+	26472758	KBM7	viability	CAAGTGGAATGACTTTGCGGAGG	OPA1	ENSG00000198836	-1.7457875519938522	[286,105]	[37,15]	-8	hSpCas9	negative selection	304873
193638009	193638032	3	+	26472758	KBM7	viability	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-2.003398780653392	[148,175]	[3,32]	-8	hSpCas9	negative selection	304874
193637259	193637282	3	+	26472758	KBM7	viability	ATACGCAAGATCATCTGCCACGG	OPA1	ENSG00000198836	-1.4258123845393833	[1537,1286]	[280,214]	-7	hSpCas9	negative selection	304875
193654952	193654975	3	+	26472758	KBM7	viability	AGGAACTTTTAACACCACAGTGG	OPA1	ENSG00000198836	-1.038409874795645	[142,85]	[12,36]	-7	hSpCas9	negative selection	304876
193659540	193659563	3	+	26472758	KBM7	viability	GAAGAATCGGACCCAAGAACAGG	OPA1	ENSG00000198836	-1.8529932398687947	[284,280]	[74,2]	-8	hSpCas9	negative selection	304877
193643389	193643412	3	+	26472758	KBM7	viability	TAAAAGGCCCTGGACTACAGAGG	OPA1	ENSG00000198836	-1.788800706402684	[810,543]	[75,103]	-8	hSpCas9	negative selection	304878
193648116	193648139	3	-	26472758	KBM7	viability	TTACCCGGTCAAGTTCCCGCAGG	OPA1	ENSG00000198836	-2.331448946427254	[523,319]	[35,40]	-9	hSpCas9	negative selection	304879
193666292	193666315	3	+	26472758	KBM7	viability	TCAGTTGGAATGCAATGATGTGG	OPA1	ENSG00000198836	-1.9914372916921625	[1580,1542]	[83,275]	-8	hSpCas9	negative selection	304880
193593383	193593406	3	+	26472758	KBM7	viability	GCGACTACGTCGGGCCGCTGTGG	OPA1	ENSG00000198836	-2.157727655212224	[70,23]	[8,0]	-8	hSpCas9	negative selection	304881
193615724	193615747	3	+	26472758	KBM7	viability	GATTGTGCCTGACATTGTGTGGG	OPA1	ENSG00000198836	0.28922458415728813	[788,893]	[612,377]	3	hSpCas9	negative selection	304882
193657202	193657225	3	+	26472758	Raji	viability	CAAGTGGAATGACTTTGCGGAGG	OPA1	ENSG00000198836	-0.5171073295341941	[110]	[17]	-4	hSpCas9	negative selection	495991
193638009	193638032	3	+	26472758	Raji	viability	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	0.8634579524875103	[44]	[18]	7	hSpCas9	negative selection	495992
193637259	193637282	3	+	26472758	Raji	viability	ATACGCAAGATCATCTGCCACGG	OPA1	ENSG00000198836	-0.5969676945378871	[553]	[84]	-5	hSpCas9	negative selection	495993
193654952	193654975	3	+	26472758	Raji	viability	AGGAACTTTTAACACCACAGTGG	OPA1	ENSG00000198836	-1.1196853731723215	[102]	[10]	-7	hSpCas9	negative selection	495994
193659540	193659563	3	+	26472758	Raji	viability	GAAGAATCGGACCCAAGAACAGG	OPA1	ENSG00000198836	-1.4775789653475568	[143]	[11]	-8	hSpCas9	negative selection	495995
193643389	193643412	3	+	26472758	Raji	viability	TAAAAGGCCCTGGACTACAGAGG	OPA1	ENSG00000198836	-0.16762351212627036	[362]	[74]	-1	hSpCas9	negative selection	495996
193648116	193648139	3	-	26472758	Raji	viability	TTACCCGGTCAAGTTCCCGCAGG	OPA1	ENSG00000198836	-0.4016301121142581	[221]	[38]	-3	hSpCas9	negative selection	495997
193666292	193666315	3	+	26472758	Raji	viability	TCAGTTGGAATGCAATGATGTGG	OPA1	ENSG00000198836	-1.2473125889831822	[756]	[73]	-7	hSpCas9	negative selection	495998
193593383	193593406	3	+	26472758	Raji	viability	GCGACTACGTCGGGCCGCTGTGG	OPA1	ENSG00000198836	-2.937010583984854	[32]	[0]	-9	hSpCas9	negative selection	495999
193615724	193615747	3	+	26472758	Raji	viability	GATTGTGCCTGACATTGTGTGGG	OPA1	ENSG00000198836	0.4054648883065939	[243]	[74]	4	hSpCas9	negative selection	496000
193657202	193657225	3	+	26472758	K562	viability	CAAGTGGAATGACTTTGCGGAGG	OPA1	ENSG00000198836	-1.413792755085348	[201]	[63]	-6	hSpCas9	negative selection	687109
193638009	193638032	3	+	26472758	K562	viability	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-0.39753375163953875	[141]	[90]	-3	hSpCas9	negative selection	687110
193637259	193637282	3	+	26472758	K562	viability	ATACGCAAGATCATCTGCCACGG	OPA1	ENSG00000198836	-0.21851127753434763	[928]	[673]	-1	hSpCas9	negative selection	687111
193654952	193654975	3	+	26472758	K562	viability	AGGAACTTTTAACACCACAGTGG	OPA1	ENSG00000198836	-2.394181736656783	[136]	[21]	-8	hSpCas9	negative selection	687112
193659540	193659563	3	+	26472758	K562	viability	GAAGAATCGGACCCAAGAACAGG	OPA1	ENSG00000198836	-1.225467248608017	[276]	[99]	-6	hSpCas9	negative selection	687113
193643389	193643412	3	+	26472758	K562	viability	TAAAAGGCCCTGGACTACAGAGG	OPA1	ENSG00000198836	-0.48178969849046094	[578]	[349]	-3	hSpCas9	negative selection	687114
193648116	193648139	3	-	26472758	K562	viability	TTACCCGGTCAAGTTCCCGCAGG	OPA1	ENSG00000198836	-0.9582962088935352	[266]	[115]	-5	hSpCas9	negative selection	687115
193666292	193666315	3	+	26472758	K562	viability	TCAGTTGGAATGCAATGATGTGG	OPA1	ENSG00000198836	0.16167829665851063	[1219]	[1151]	1	hSpCas9	negative selection	687116
193593383	193593406	3	+	26472758	K562	viability	GCGACTACGTCGGGCCGCTGTGG	OPA1	ENSG00000198836	-4.3405437730547085	[23]	[0]	-9	hSpCas9	negative selection	687117
193615724	193615747	3	+	26472758	K562	viability	GATTGTGCCTGACATTGTGTGGG	OPA1	ENSG00000198836	0.42310063029412104	[583]	[660]	3	hSpCas9	negative selection	687118
193637260	193637283	3	+	26627737	DLD1	viability	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	-5.756969696708606	[172]	[0,0,0]	-9	hSpCas9	negative selection	820987
193638009	193638032	3	+	26627737	DLD1	viability	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-2.2425425643617207	[385]	[13,48,15]	-9	hSpCas9	negative selection	820988
193647143	193647166	3	+	26627737	DLD1	viability	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	0.4454477284605337	[656]	[217,344,278]	4	hSpCas9	negative selection	820989
193648113	193648136	3	+	26627737	DLD1	viability	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	-1.0751605239230662	[337]	[45,44,57]	-7	hSpCas9	negative selection	820990
193654929	193654952	3	-	26627737	DLD1	viability	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	-2.143763162583742	[159]	[16,12,4]	-9	hSpCas9	negative selection	820991
193637260	193637283	3	+	26627737	GBM cells	viability after 5 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	-0.6402449362223459	[92]	[24,38]	-7	hSpCas9	negative selection	903302
193638009	193638032	3	+	26627737	GBM cells	viability after 5 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	0.0731648017307881	[295]	[166,166]	1	hSpCas9	negative selection	903303
193647143	193647166	3	+	26627737	GBM cells	viability after 5 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	0.5925576945606098	[310]	[298,203]	8	hSpCas9	negative selection	903304
193648113	193648136	3	+	26627737	GBM cells	viability after 5 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	-0.49605800133905265	[237]	[88,91]	-7	hSpCas9	negative selection	903305
193654929	193654952	3	-	26627737	GBM cells	viability after 5 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	-0.004224585861725361	[71]	[43,32]	0	hSpCas9	negative selection	903306
193637260	193637283	3	+	26627737	GBM cells	viability after 13 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	-0.7957862889603096	[92]	[22,33]	-7	hSpCas9	negative selection	985617
193638009	193638032	3	+	26627737	GBM cells	viability after 13 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-0.95589387633325	[295]	[84,80]	-8	hSpCas9	negative selection	985618
193647143	193647166	3	+	26627737	GBM cells	viability after 13 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	0.5069848118766829	[310]	[241,237]	6	hSpCas9	negative selection	985619
193648113	193648136	3	+	26627737	GBM cells	viability after 13 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	-1.8837347418193433	[237]	[18,47]	-9	hSpCas9	negative selection	985620
193654929	193654952	3	-	26627737	GBM cells	viability after 13 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	0.014346620146316713	[71]	[55,25]	0	hSpCas9	negative selection	985621
193637260	193637283	3	+	26627737	GBM cells	viability after 21 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	-4.349878707901743	[92]	[2,1]	-9	hSpCas9	negative selection	1067932
193638009	193638032	3	+	26627737	GBM cells	viability after 21 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-4.754983971885193	[295]	[6,4]	-9	hSpCas9	negative selection	1067933
193647143	193647166	3	+	26627737	GBM cells	viability after 21 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	1.0142182248679181	[310]	[334,346]	8	hSpCas9	negative selection	1067934
193648113	193648136	3	+	26627737	GBM cells	viability after 21 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	-1.5496984149628799	[237]	[51,36]	-8	hSpCas9	negative selection	1067935
193654929	193654952	3	-	26627737	GBM cells	viability after 21 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	-0.32365096084162914	[71]	[36,25]	-3	hSpCas9	negative selection	1067936
193637260	193637283	3	+	26627737	RPE1	viability after 9 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	7.961630062513732	[0]	[5,170]	9	hSpCas9	negative selection	1150247
193638009	193638032	3	+	26627737	RPE1	viability after 9 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-0.21876504827162363	[1084]	[297,283]	-1	hSpCas9	negative selection	1150248
193647143	193647166	3	+	26627737	RPE1	viability after 9 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	0.8744347902393037	[1224]	[651,768]	5	hSpCas9	negative selection	1150249
193648113	193648136	3	+	26627737	RPE1	viability after 9 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	0.8397277184524023	[292]	[185,135]	5	hSpCas9	negative selection	1150250
193654929	193654952	3	-	26627737	RPE1	viability after 9 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	-0.7251003310101674	[272]	[59,40]	-5	hSpCas9	negative selection	1150251
193637260	193637283	3	+	26627737	RPE1	viability after 12 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	7.244586661172059	[0]	[14,67]	9	hSpCas9	negative selection	1232562
193638009	193638032	3	+	26627737	RPE1	viability after 12 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-0.6482091045506726	[1084]	[168,203]	-4	hSpCas9	negative selection	1232563
193647143	193647166	3	+	26627737	RPE1	viability after 12 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	0.5983747805025272	[1224]	[473,523]	4	hSpCas9	negative selection	1232564
193648113	193648136	3	+	26627737	RPE1	viability after 12 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	-0.29221917358967686	[292]	[39,89]	-2	hSpCas9	negative selection	1232565
193654929	193654952	3	-	26627737	RPE1	viability after 12 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	-1.94006634555022	[272]	[22,14]	-8	hSpCas9	negative selection	1232566
193637260	193637283	3	+	26627737	RPE1	viability after 15 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	6.8232780706100105	[0]	[1,60]	9	hSpCas9	negative selection	1314877
193638009	193638032	3	+	26627737	RPE1	viability after 15 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-1.653429630709686	[1084]	[121,73]	-7	hSpCas9	negative selection	1314878
193647143	193647166	3	+	26627737	RPE1	viability after 15 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	0.39256837357895735	[1224]	[488,421]	2	hSpCas9	negative selection	1314879
193648113	193648136	3	+	26627737	RPE1	viability after 15 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	0.06003453584860563	[292]	[147,26]	0	hSpCas9	negative selection	1314880
193654929	193654952	3	-	26627737	RPE1	viability after 15 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	-1.4238729552561378	[272]	[40,16]	-7	hSpCas9	negative selection	1314881
193637260	193637283	3	+	26627737	RPE1	viability after 18 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	6.399790252104744	[0]	[1,44]	9	hSpCas9	negative selection	1397192
193638009	193638032	3	+	26627737	RPE1	viability after 18 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-1.82529426171018	[1084]	[129,31]	-8	hSpCas9	negative selection	1397193
193647143	193647166	3	+	26627737	RPE1	viability after 18 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	0.49376161609520874	[1224]	[421,511]	3	hSpCas9	negative selection	1397194
193648113	193648136	3	+	26627737	RPE1	viability after 18 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	-1.6738684281818492	[292]	[32,15]	-7	hSpCas9	negative selection	1397195
193654929	193654952	3	-	26627737	RPE1	viability after 18 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	-2.5765667009581605	[272]	[7,16]	-8	hSpCas9	negative selection	1397196
193637260	193637283	3	+	26627737	HeLa	viability after 8 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	0.32030925278939026	[39]	[63,10,0]	3	hSpCas9	negative selection	1479507
193638009	193638032	3	+	26627737	HeLa	viability after 8 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-2.8818428014668998	[655]	[22,69,20]	-9	hSpCas9	negative selection	1479508
193647143	193647166	3	+	26627737	HeLa	viability after 8 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	0.9726859482889624	[528]	[443,553,361]	7	hSpCas9	negative selection	1479509
193648113	193648136	3	+	26627737	HeLa	viability after 8 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	-2.098033159447658	[359]	[23,1,77]	-9	hSpCas9	negative selection	1479510
193654929	193654952	3	-	26627737	HeLa	viability after 8 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	0.2730738695289099	[151]	[109,109,29]	2	hSpCas9	negative selection	1479511
193637260	193637283	3	+	26627737	HeLa	viability after 12 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	-4.047069967686049	[39]	[0,0,0]	-9	hSpCas9	negative selection	1561822
193638009	193638032	3	+	26627737	HeLa	viability after 12 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-2.0833309617935942	[655]	[89,41,62]	-9	hSpCas9	negative selection	1561823
193647143	193647166	3	+	26627737	HeLa	viability after 12 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	0.8811269407120582	[528]	[508,270,444]	6	hSpCas9	negative selection	1561824
193648113	193648136	3	+	26627737	HeLa	viability after 12 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	-3.311704785117013	[359]	[21,6,16]	-9	hSpCas9	negative selection	1561825
193654929	193654952	3	-	26627737	HeLa	viability after 12 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	0.42693735139262234	[151]	[156,50,50]	3	hSpCas9	negative selection	1561826
193637260	193637283	3	+	26627737	HeLa	viability after 15 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	-4.025394982579357	[39]	[0,0,0]	-9	hSpCas9	negative selection	1644137
193638009	193638032	3	+	26627737	HeLa	viability after 15 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-2.226758921482617	[655]	[51,76,40]	-9	hSpCas9	negative selection	1644138
193647143	193647166	3	+	26627737	HeLa	viability after 15 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	1.226786787257593	[528]	[560,329,629]	8	hSpCas9	negative selection	1644139
193648113	193648136	3	+	26627737	HeLa	viability after 15 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	-3.9814061614220915	[359]	[24,0,0]	-9	hSpCas9	negative selection	1644140
193654929	193654952	3	-	26627737	HeLa	viability after 15 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	-1.3620452318971434	[151]	[10,41,18]	-8	hSpCas9	negative selection	1644141
193637260	193637283	3	+	26627737	HeLa	viability after 18 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	-3.71518933092549	[39]	[0,0,0]	-9	hSpCas9	negative selection	1726452
193638009	193638032	3	+	26627737	HeLa	viability after 18 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-2.2022262490789153	[655]	[34,65,40]	-9	hSpCas9	negative selection	1726453
193647143	193647166	3	+	26627737	HeLa	viability after 18 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	1.230884056761667	[528]	[376,275,629]	8	hSpCas9	negative selection	1726454
193648113	193648136	3	+	26627737	HeLa	viability after 18 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	-4.521567148278701	[359]	[10,0,0]	-9	hSpCas9	negative selection	1726455
193654929	193654952	3	-	26627737	HeLa	viability after 18 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	-1.1827171142718003	[151]	[10,37,18]	-8	hSpCas9	negative selection	1726456
193637260	193637283	3	+	26627737	HCT116	viability after 6 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	1.0366136549830671	[299]	[1,148]	5	hSpCas9	negative selection	1808767
193638009	193638032	3	+	26627737	HCT116	viability after 6 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-2.4337095668632625	[558]	[23,11]	-8	hSpCas9	negative selection	1808768
193647143	193647166	3	+	26627737	HCT116	viability after 6 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	0.01603951341231935	[889]	[339,31]	0	hSpCas9	negative selection	1808769
193648113	193648136	3	+	26627737	HCT116	viability after 6 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	0.7733544720018943	[365]	[20,140]	4	hSpCas9	negative selection	1808770
193654929	193654952	3	-	26627737	HCT116	viability after 6 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	-2.1431683294658135	[107]	[8,0]	-8	hSpCas9	negative selection	1808771
193637260	193637283	3	+	26627737	HCT116	viability after 8 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	-1.5507498990837711	[106]	[41,17,0]	-9	hSpCas9	negative selection	1891082
193638009	193638032	3	+	26627737	HCT116	viability after 8 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-1.3575993737081617	[395]	[69,84,99]	-9	hSpCas9	negative selection	1891083
193647143	193647166	3	+	26627737	HCT116	viability after 8 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	-0.31909295356405853	[389]	[217,160,138]	-4	hSpCas9	negative selection	1891084
193648113	193648136	3	+	26627737	HCT116	viability after 8 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	-0.6139501553664632	[270]	[108,92,90]	-6	hSpCas9	negative selection	1891085
193654929	193654952	3	-	26627737	HCT116	viability after 8 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	-0.006367444186178517	[54]	[45,30,13]	0	hSpCas9	negative selection	1891086
193637260	193637283	3	+	26627737	HCT116	viability after 9 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	-4.85614990012234	[299]	[4,0]	-9	hSpCas9	negative selection	1973397
193638009	193638032	3	+	26627737	HCT116	viability after 9 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-0.04476660347789352	[558]	[261,51]	0	hSpCas9	negative selection	1973398
193647143	193647166	3	+	26627737	HCT116	viability after 9 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	-1.475959760224743	[889]	[66,99]	-8	hSpCas9	negative selection	1973399
193648113	193648136	3	+	26627737	HCT116	viability after 9 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	-1.4443998984416218	[365]	[31,38]	-7	hSpCas9	negative selection	1973400
193654929	193654952	3	-	26627737	HCT116	viability after 9 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	-1.0388340390984365	[107]	[27,2]	-6	hSpCas9	negative selection	1973401
193637260	193637283	3	+	26627737	HCT116	viability after 12 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	-1.6435547419651502	[106]	[35,0,14]	-9	hSpCas9	negative selection	2055712
193638009	193638032	3	+	26627737	HCT116	viability after 12 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-1.8188528026080117	[395]	[27,71,79]	-9	hSpCas9	negative selection	2055713
193647143	193647166	3	+	26627737	HCT116	viability after 12 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	-0.20725378049870724	[389]	[185,183,161]	-2	hSpCas9	negative selection	2055714
193648113	193648136	3	+	26627737	HCT116	viability after 12 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	-1.8319199051327413	[270]	[53,48,15]	-9	hSpCas9	negative selection	2055715
193654929	193654952	3	-	26627737	HCT116	viability after 12 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	-0.07466190425542774	[54]	[21,34,25]	0	hSpCas9	negative selection	2055716
193637260	193637283	3	+	26627737	HCT116	viability after 15 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	-3.109867481503649	[106]	[4,0,14]	-9	hSpCas9	negative selection	2138027
193638009	193638032	3	+	26627737	HCT116	viability after 15 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-3.3103393729086426	[395]	[38,30,0]	-9	hSpCas9	negative selection	2138028
193647143	193647166	3	+	26627737	HCT116	viability after 15 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	0.20194016460841618	[389]	[225,282,259]	2	hSpCas9	negative selection	2138029
193648113	193648136	3	+	26627737	HCT116	viability after 15 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	-2.598098859225728	[270]	[16,28,29]	-9	hSpCas9	negative selection	2138030
193654929	193654952	3	-	26627737	HCT116	viability after 15 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	0.41432829796372195	[54]	[57,9,59]	4	hSpCas9	negative selection	2138031
193637260	193637283	3	+	26627737	HCT116	viability after 18 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	-4.959764718450379	[106]	[2,0,0]	-9	hSpCas9	negative selection	2220342
193638009	193638032	3	+	26627737	HCT116	viability after 18 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-4.335812561914974	[395]	[14,10,1]	-9	hSpCas9	negative selection	2220343
193647143	193647166	3	+	26627737	HCT116	viability after 18 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	0.21708437410908393	[389]	[288,168,201]	2	hSpCas9	negative selection	2220344
193648113	193648136	3	+	26627737	HCT116	viability after 18 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	-3.116468284639148	[270]	[4,21,17]	-9	hSpCas9	negative selection	2220345
193654929	193654952	3	-	26627737	HCT116	viability after 18 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	0.30349750164183087	[54]	[32,27,37]	2	hSpCas9	negative selection	2220346
193597866	193597889	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGAGTTTGAGACCAGCCTAGG	OPA1	ENSG00000198836	-1.6026008362934678	[306,558]	[26,34]	-8	dCas9-VP64	positive selection	2428529
193634576	193634599	3	-	25494202	A375	resistance to PLX-4720 (puromycin)	GTCTCTACTAAAAATTAGCCAGG	OPA1	ENSG00000198836	1.3560847415451704	[457,183]	[330,15]	5	dCas9-VP64	positive selection	2432988
193658199	193658222	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	CGTGCCATTGCACTCCAGCCAAG	OPA1	ENSG00000198836	-0.5971814264096912	[233,130]	[36,14]	-3	dCas9-VP64	positive selection	2446962
193597479	193597502	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	TTAGGAGTTCGAGACCAGCCTGG	OPA1	ENSG00000198836	-0.8844378867613548	[237,84]	[20,15]	-5	dCas9-VP64	positive selection	2461548
193679308	193679331	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	AGAGAGGGAGGGAGGGAGGGAAG	OPA1	ENSG00000198836	0.9305428154912776	[3,4]	[0,1]	4	dCas9-VP64	positive selection	2467704
193597866	193597889	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGAGTTTGAGACCAGCCTAGG	OPA1	ENSG00000198836	0.9241793657004961	[25,55]	[22,26]	6	dCas9-VP64	positive selection	2523784
193634576	193634599	3	-	25494202	A375	resistance to PLX-4720 (zeocin)	GTCTCTACTAAAAATTAGCCAGG	OPA1	ENSG00000198836	0.28367665174822726	[115,68]	[27,44]	2	dCas9-VP64	positive selection	2528243
193658199	193658222	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	CGTGCCATTGCACTCCAGCCAAG	OPA1	ENSG00000198836	0.14726127288975888	[140,101]	[59,28]	1	dCas9-VP64	positive selection	2542217
193597479	193597502	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	TTAGGAGTTCGAGACCAGCCTGG	OPA1	ENSG00000198836	2.6650986342381273	[238,153]	[58,738]	9	dCas9-VP64	positive selection	2556803
193679308	193679331	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	AGAGAGGGAGGGAGGGAGGGAAG	OPA1	ENSG00000198836	0.5788861668152605	[2,6]	[2,1]	4	dCas9-VP64	positive selection	2562959
193644030	193644053	3	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	ATATGGTTCTCCTTCCATGAGGG	OPA1	ENSG00000198836	-1.067367343855626	[3,3]	[1,0]	-9	hSpCas9	positive selection	3007408
193614863	193614886	3	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CAGAGAAGAGAACTGCTGAAAGG	OPA1	ENSG00000198836	-1.0932228028961466	[2,2]	[0,0]	-9	hSpCas9	positive selection	3007409
193614940	193614963	3	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCTGGCCAAAAATTCCTGCGAGG	OPA1	ENSG00000198836	-0.29475885128054063	[3,3]	[3,0]	-4	hSpCas9	positive selection	3007410
193644030	193644053	3	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	ATATGGTTCTCCTTCCATGAGGG	OPA1	ENSG00000198836	-0.9323154642160055	[3,3]	[1,0]	-9	hSpCas9	positive selection	3075266
193614863	193614886	3	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CAGAGAAGAGAACTGCTGAAAGG	OPA1	ENSG00000198836	-0.9306687528848011	[2,2]	[0,0]	-9	hSpCas9	positive selection	3075267
193614940	193614963	3	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCTGGCCAAAAATTCCTGCGAGG	OPA1	ENSG00000198836	-0.19391387653883604	[3,3]	[3,0]	-3	hSpCas9	positive selection	3075268
193631623	193631646		+	24336571	A375	resistance to PLX after 7 days	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	0.3498379637180563	[20,15]	[24,22]	8	hSpCas9	positive selection	3132456
193615702	193615725		+	24336571	A375	resistance to PLX after 7 days	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	-0.282608376755336	[2,3]	[3,1]	-8	hSpCas9	positive selection	3132457
193631635	193631658		-	24336571	A375	resistance to PLX after 7 days	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.27918850824617847	[5,7]	[9,7]	7	hSpCas9	positive selection	3132458
193631623	193631646		+	24336571	A375	resistance to PLX after 14 days	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	1.2468023438490112	[14,10]	[13,14]	8	hSpCas9	positive selection	3190249
193615702	193615725		+	24336571	A375	resistance to PLX after 14 days	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.46812609588434295	[2,2]	[1,1]	4	hSpCas9	positive selection	3190250
193631635	193631658		-	24336571	A375	resistance to PLX after 14 days	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.15556426864879702	[5,6]	[2,2]	1	hSpCas9	positive selection	3190251
193631623	193631646		+	24336571	A375	viability after 7 days	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.3817843852873428	[25]	[20,15]	-5	hSpCas9	negative selection	3248042
193615702	193615725		+	24336571	A375	viability after 7 days	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	-1.0309234117336592	[8]	[2,3]	-9	hSpCas9	negative selection	3248043
193631635	193631658		-	24336571	A375	viability after 7 days	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	-0.5845397790118847	[11]	[5,7]	-7	hSpCas9	negative selection	3248044
193631623	193631646		+	24336571	A375	viability after 14 days	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.8439159794542215	[25]	[14,10]	-8	hSpCas9	negative selection	3305835
193615702	193615725		+	24336571	A375	viability after 14 days	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	-1.236121169806267	[8]	[2,2]	-9	hSpCas9	negative selection	3305836
193631635	193631658		-	24336571	A375	viability after 14 days	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	-0.7022588295509171	[11]	[5,6]	-7	hSpCas9	negative selection	3305837
193635501	193635524	3	+	27383988	293T	resistance to West Nile virus (flavivirus)	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	-0.4291743157373832	[205,205]	[0,0]	-3	hSpCas9	positive selection	3383028
193631635	193631658	3	-	27383988	293T	resistance to West Nile virus (flavivirus)	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.47596649792117546	[109,109]	[0,0]	2	hSpCas9	positive selection	3383029
193631623	193631646	3	+	27383988	293T	resistance to West Nile virus (flavivirus)	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	0.5849008694743394	[101,101]	[0,0]	3	hSpCas9	positive selection	3383030
193644030	193644053	3	-	26780180	HT29	viability (Avana library 4 designs)	ATATGGTTCTCCTTCCATGAGGG	OPA1	ENSG00000198836	4.09640892233615	[]	[]	9	hSpCas9	negative selection	3445332
193614863	193614886	3	-	26780180	HT29	viability (Avana library 4 designs)	CAGAGAAGAGAACTGCTGAAAGG	OPA1	ENSG00000198836	2.72953020771745	[]	[]	8	hSpCas9	negative selection	3445333
193614940	193614963	3	-	26780180	HT29	viability (Avana library 4 designs)	GCTGGCCAAAAATTCCTGCGAGG	OPA1	ENSG00000198836	1.39229757781121	[]	[]	5	hSpCas9	negative selection	3445334
193614940	193614963	3	-	26780180	A375	viability (Avana lentiCRISPRv2)	GCTGGCCAAAAATTCCTGCGAGG	OPA1	ENSG00000198836	5.10674033174972	[]	[]	8	hSpCas9	negative selection	3538012
193644030	193644053	3	-	26780180	A375	viability (Avana lentiCRISPRv2)	ATATGGTTCTCCTTCCATGAGGG	OPA1	ENSG00000198836	0.148965058863542	[]	[]	0	hSpCas9	negative selection	3538013
193614863	193614886	3	-	26780180	A375	viability (Avana lentiCRISPRv2)	CAGAGAAGAGAACTGCTGAAAGG	OPA1	ENSG00000198836	0.922117289278965	[]	[]	1	hSpCas9	negative selection	3538014
193593397	193593420	3	-	26780180	A375	viability (Avana lentiCRISPRv2)	CTGCACTTACCAGGCCACAGCGG	OPA1	ENSG00000198836	0.372523079843645	[]	[]	0	hSpCas9	negative selection	3538015
193643396	193643419	3	-	26780180	A375	viability (Avana lentiCRISPRv2)	GCACCATCCTCTGTAGTCCAGGG	OPA1	ENSG00000198836	1.63831354808081	[]	[]	2	hSpCas9	negative selection	3538016
193614940	193614963	3	-	26780180	A375	viability (Avana lentiGuide)	GCTGGCCAAAAATTCCTGCGAGG	OPA1	ENSG00000198836	6.24900862578427	[]	[]	5	hSpCas9	negative selection	3646671
193644030	193644053	3	-	26780180	A375	viability (Avana lentiGuide)	ATATGGTTCTCCTTCCATGAGGG	OPA1	ENSG00000198836	12.1248364486066	[]	[]	7	hSpCas9	negative selection	3646672
193614863	193614886	3	-	26780180	A375	viability (Avana lentiGuide)	CAGAGAAGAGAACTGCTGAAAGG	OPA1	ENSG00000198836	13.9797561009151	[]	[]	7	hSpCas9	negative selection	3646673
193593397	193593420	3	-	26780180	A375	viability (Avana lentiGuide)	CTGCACTTACCAGGCCACAGCGG	OPA1	ENSG00000198836	8.46571798366611	[]	[]	6	hSpCas9	negative selection	3646674
193643396	193643419	3	-	26780180	A375	viability (Avana lentiGuide)	GCACCATCCTCTGTAGTCCAGGG	OPA1	ENSG00000198836	6.5790807802877	[]	[]	5	hSpCas9	negative selection	3646675
193614940	193614963	3	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCTGGCCAAAAATTCCTGCGAGG	OPA1	ENSG00000198836	0.3388690937037948	[3]	[5,4]	8	hSpCas9	positive selection	3755330
193644030	193644053	3	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ATATGGTTCTCCTTCCATGAGGG	OPA1	ENSG00000198836	-0.16570367604059877	[5]	[6,3]	-3	hSpCas9	positive selection	3755331
193614863	193614886	3	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CAGAGAAGAGAACTGCTGAAAGG	OPA1	ENSG00000198836	0.29569475194960365	[4]	[5,5]	8	hSpCas9	positive selection	3755332
193593397	193593420	3	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CTGCACTTACCAGGCCACAGCGG	OPA1	ENSG00000198836	0.21057465753248655	[5]	[5,5]	6	hSpCas9	positive selection	3755333
193643396	193643419	3	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCACCATCCTCTGTAGTCCAGGG	OPA1	ENSG00000198836	0.22955054794923604	[5]	[7,6]	6	hSpCas9	positive selection	3755334
193614940	193614963	3	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCTGGCCAAAAATTCCTGCGAGG	OPA1	ENSG00000198836	0.0069702925450397385	[4]	[5,2]	0	hSpCas9	positive selection	3863937
193644030	193644053	3	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ATATGGTTCTCCTTCCATGAGGG	OPA1	ENSG00000198836	0.09062120617009747	[5]	[5,3]	2	hSpCas9	positive selection	3863938
193614863	193614886	3	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CAGAGAAGAGAACTGCTGAAAGG	OPA1	ENSG00000198836	-0.011254540357935494	[3]	[3,1]	0	hSpCas9	positive selection	3863939
193593397	193593420	3	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CTGCACTTACCAGGCCACAGCGG	OPA1	ENSG00000198836	0.007224871867415453	[5]	[4,5]	0	hSpCas9	positive selection	3863940
193643396	193643419	3	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCACCATCCTCTGTAGTCCAGGG	OPA1	ENSG00000198836	0.10564930166351966	[7]	[6,6]	2	hSpCas9	positive selection	3863941
193631623	193631646	3	+	26780180	A375	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	1.2569231407862	[]	[]	6	hSpCas9	negative selection	3975086
193615749	193615772	3	+	26780180	A375	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.329825329964552	[]	[]	0	hSpCas9	negative selection	3975087
193635501	193635524	3	+	26780180	A375	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.601738436269094	[]	[]	2	hSpCas9	negative selection	3975088
193615702	193615725	3	+	26780180	A375	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	1.05363465808519	[]	[]	5	hSpCas9	negative selection	3975089
193631635	193631658	3	-	26780180	A375	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	1.20715846652054	[]	[]	6	hSpCas9	negative selection	3975090
193635417	193635440	3	+	26780180	A375	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	1.01011462025522	[]	[]	5	hSpCas9	negative selection	3975091
193631623	193631646	3	+	26780180	HT29	viability (GeCKOv2 library)	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	1.16667085429239	[]	[]	5	hSpCas9	negative selection	4083052
193615749	193615772	3	+	26780180	HT29	viability (GeCKOv2 library)	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.180475597114941	[]	[]	0	hSpCas9	negative selection	4083053
193635501	193635524	3	+	26780180	HT29	viability (GeCKOv2 library)	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	1.3017359504454	[]	[]	6	hSpCas9	negative selection	4083054
193615702	193615725	3	+	26780180	HT29	viability (GeCKOv2 library)	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.645522905148741	[]	[]	2	hSpCas9	negative selection	4083055
193631635	193631658	3	-	26780180	HT29	viability (GeCKOv2 library)	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	1.48251451671502	[]	[]	7	hSpCas9	negative selection	4083056
193635417	193635440	3	+	26780180	HT29	viability (GeCKOv2 library)	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	0.507451759109846	[]	[]	1	hSpCas9	negative selection	4083057
193631623	193631646	3	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	0.15954033449433788	[4]	[2,3]	4	hSpCas9	positive selection	4157249
193615702	193615725	3	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.19452855746776576	[1]	[0,0]	5	hSpCas9	positive selection	4157250
193631635	193631658	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	-0.2710431588267657	[3]	[2,1]	-6	hSpCas9	positive selection	4157251
193631623	193631646	3	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	0.10996758265175666	[3]	[2,1,3,0]	0	hSpCas9	positive selection	4221271
193615702	193615725	3	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.6942108945882255	[3]	[0,0,1,3]	4	hSpCas9	positive selection	4221272
193631635	193631658	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	-0.14548197469695345	[2]	[1,0,0,0]	-2	hSpCas9	positive selection	4221273
193615702	193615725	3	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.0568402246993249	[2]	[2,1]	1	hSpCas9	positive selection	4287057
193615749	193615772	3	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.6148352534908947	[4]	[4,5]	9	hSpCas9	positive selection	4287058
193635417	193635440	3	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	0.14801219539612503	[3]	[3,2]	3	hSpCas9	positive selection	4287059
193635501	193635524	3	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.4110550732172085	[2]	[2,2]	8	hSpCas9	positive selection	4351314
193631635	193631658	3	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	-0.6866464864922435	[1]	[0,0]	-9	hSpCas9	positive selection	4351315
193631623	193631646	3	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.35197256276412864	[2]	[1,0]	-6	hSpCas9	positive selection	4351316
193614826	193614848	3	-	27760321	OCIAML3	viability	GTCGTTGAAGCTTTAAGGTAGG	OPA1	ENSG00000198836	-1.9159825497941954	[202,208]	[51,30]	-9	hSpCas9	negative selection	4424621
193643034	193643056	3	+	27760321	OCIAML3	viability	TACCGTTAGCCCTGAGGTAAGG	OPA1	ENSG00000198836	-0.7781415343156838	[431,310]	[178,152]	-6	hSpCas9	negative selection	4424622
193637250	193637272	3	-	27760321	OCIAML3	viability	TGATCTTGCGTATTATAACTGG	OPA1	ENSG00000198836	-3.6574886869584846	[14,16]	[0,0]	-9	hSpCas9	negative selection	4424623
193638010	193638032	3	+	27760321	OCIAML3	viability	AAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-0.30337139030672966	[182,172]	[62,177]	-3	hSpCas9	negative selection	4424624
193614826	193614848	3	-	27760321	OCIAML2	viability	GTCGTTGAAGCTTTAAGGTAGG	OPA1	ENSG00000198836	-1.2305335157106978	[202,208]	[63,80]	-8	hSpCas9	negative selection	4508084
193643034	193643056	3	+	27760321	OCIAML2	viability	TACCGTTAGCCCTGAGGTAAGG	OPA1	ENSG00000198836	-1.7545915332559665	[431,310]	[63,119]	-9	hSpCas9	negative selection	4508085
193637250	193637272	3	-	27760321	OCIAML2	viability	TGATCTTGCGTATTATAACTGG	OPA1	ENSG00000198836	-3.7062340522235333	[14,16]	[0,0]	-9	hSpCas9	negative selection	4508086
193638010	193638032	3	+	27760321	OCIAML2	viability	AAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-0.7359346508562958	[182,172]	[48,135]	-6	hSpCas9	negative selection	4508087
193614826	193614848	3	-	27760321	MV411	viability	GTCGTTGAAGCTTTAAGGTAGG	OPA1	ENSG00000198836	-2.196382889739347	[202,208]	[20,42]	-8	hSpCas9	negative selection	4591547
193643034	193643056	3	+	27760321	MV411	viability	TACCGTTAGCCCTGAGGTAAGG	OPA1	ENSG00000198836	-0.04970316030386707	[431,310]	[309,120]	0	hSpCas9	negative selection	4591548
193637250	193637272	3	-	27760321	MV411	viability	TGATCTTGCGTATTATAACTGG	OPA1	ENSG00000198836	-3.4124101180438027	[14,16]	[0,0]	-9	hSpCas9	negative selection	4591549
193638010	193638032	3	+	27760321	MV411	viability	AAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-0.3301999743170734	[182,172]	[1,230]	-2	hSpCas9	negative selection	4591550
193614826	193614848	3	-	27760321	HL60	viability	GTCGTTGAAGCTTTAAGGTAGG	OPA1	ENSG00000198836	-2.162775411784321	[202,208]	[45,28]	-9	hSpCas9	negative selection	4675010
193643034	193643056	3	+	27760321	HL60	viability	TACCGTTAGCCCTGAGGTAAGG	OPA1	ENSG00000198836	-0.9034748080083858	[431,310]	[196,121]	-7	hSpCas9	negative selection	4675011
193637250	193637272	3	-	27760321	HL60	viability	TGATCTTGCGTATTATAACTGG	OPA1	ENSG00000198836	3.216924228557832	[14,16]	[90,155]	9	hSpCas9	negative selection	4675012
193638010	193638032	3	+	27760321	HL60	viability	AAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-1.45343433547052	[182,172]	[57,47]	-8	hSpCas9	negative selection	4675013
193614826	193614848	3	-	27760321	HT1080	viability	GTCGTTGAAGCTTTAAGGTAGG	OPA1	ENSG00000198836	-1.865173325182055	[208,162]	[37,0]	-6	hSpCas9	negative selection	4758473
193643034	193643056	3	+	27760321	HT1080	viability	TACCGTTAGCCCTGAGGTAAGG	OPA1	ENSG00000198836	-1.4585795180591865	[310,242]	[74,1]	-5	hSpCas9	negative selection	4758474
193637250	193637272	3	-	27760321	HT1080	viability	TGATCTTGCGTATTATAACTGG	OPA1	ENSG00000198836	3.71194615044741	[16,12]	[71,84]	9	hSpCas9	negative selection	4758475
193638010	193638032	3	+	27760321	HT1080	viability	AAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-5.9389561314226675	[172,134]	[0,0]	-9	hSpCas9	negative selection	4758476
193614826	193614848	3	-	27760321	HT29	viability after 7 days	GTCGTTGAAGCTTTAAGGTAGG	OPA1	ENSG00000198836	-0.58839237921973	[208,162]	[194,158,128]	-7	hSpCas9	negative selection	4841936
193643034	193643056	3	+	27760321	HT29	viability after 7 days	TACCGTTAGCCCTGAGGTAAGG	OPA1	ENSG00000198836	0.4041288563043019	[310,242]	[449,640,323]	6	hSpCas9	negative selection	4841937
193637250	193637272	3	-	27760321	HT29	viability after 7 days	TGATCTTGCGTATTATAACTGG	OPA1	ENSG00000198836	-0.08956277614157493	[16,12]	[0,5,43]	-1	hSpCas9	negative selection	4841938
193638010	193638032	3	+	27760321	HT29	viability after 7 days	AAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-0.1888194533455898	[172,134]	[180,169,170]	-3	hSpCas9	negative selection	4841939
193614826	193614848	3	-	27760321	HT29	viability after 25 days	GTCGTTGAAGCTTTAAGGTAGG	OPA1	ENSG00000198836	-0.3091260288581231	[208,162]	[132,210,172]	-3	hSpCas9	negative selection	4925399
193643034	193643056	3	+	27760321	HT29	viability after 25 days	TACCGTTAGCCCTGAGGTAAGG	OPA1	ENSG00000198836	-0.3822992087776296	[310,242]	[238,190,304]	-4	hSpCas9	negative selection	4925400
193637250	193637272	3	-	27760321	HT29	viability after 25 days	TGATCTTGCGTATTATAACTGG	OPA1	ENSG00000198836	-0.9205267935591506	[16,12]	[0,22,2]	-6	hSpCas9	negative selection	4925401
193638010	193638032	3	+	27760321	HT29	viability after 25 days	AAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-0.778119523883327	[172,134]	[138,101,59]	-6	hSpCas9	negative selection	4925402
193614826	193614848	3	-	27760321	HT29	viability after 22 days	GTCGTTGAAGCTTTAAGGTAGG	OPA1	ENSG00000198836	-0.8681039218623366	[208,162]	[105,99,147]	-6	hSpCas9	negative selection	5008862
193643034	193643056	3	+	27760321	HT29	viability after 22 days	TACCGTTAGCCCTGAGGTAAGG	OPA1	ENSG00000198836	-0.767018054034428	[310,242]	[83,333,148]	-6	hSpCas9	negative selection	5008863
193637250	193637272	3	-	27760321	HT29	viability after 22 days	TGATCTTGCGTATTATAACTGG	OPA1	ENSG00000198836	-1.0136738353108266	[16,12]	[1,5,17]	-6	hSpCas9	negative selection	5008864
193638010	193638032	3	+	27760321	HT29	viability after 22 days	AAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-0.3406975596739603	[172,134]	[186,143,88]	-3	hSpCas9	negative selection	5008865
193614826	193614848	3	-	27760321	HT29	viability after 19 days	GTCGTTGAAGCTTTAAGGTAGG	OPA1	ENSG00000198836	-0.7184618855669173	[208,162]	[86,104,188]	-5	hSpCas9	negative selection	5092325
193643034	193643056	3	+	27760321	HT29	viability after 19 days	TACCGTTAGCCCTGAGGTAAGG	OPA1	ENSG00000198836	-0.36476850280111706	[310,242]	[446,226,90]	-3	hSpCas9	negative selection	5092326
193637250	193637272	3	-	27760321	HT29	viability after 19 days	TGATCTTGCGTATTATAACTGG	OPA1	ENSG00000198836	-3.348541867523033	[16,12]	[0,2,0]	-9	hSpCas9	negative selection	5092327
193638010	193638032	3	+	27760321	HT29	viability after 19 days	AAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-0.4339484053483065	[172,134]	[189,149,59]	-4	hSpCas9	negative selection	5092328
193614826	193614848	3	-	27760321	HT29	viability after 16 days	GTCGTTGAAGCTTTAAGGTAGG	OPA1	ENSG00000198836	-1.153223540881748	[208,162]	[88,25,166]	-7	hSpCas9	negative selection	5175788
193643034	193643056	3	+	27760321	HT29	viability after 16 days	TACCGTTAGCCCTGAGGTAAGG	OPA1	ENSG00000198836	0.20104130270110404	[310,242]	[472,309,297]	2	hSpCas9	negative selection	5175789
193637250	193637272	3	-	27760321	HT29	viability after 16 days	TGATCTTGCGTATTATAACTGG	OPA1	ENSG00000198836	-4.066949790541458	[16,12]	[0,0,0]	-9	hSpCas9	negative selection	5175790
193638010	193638032	3	+	27760321	HT29	viability after 16 days	AAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-0.3221211558936514	[172,134]	[164,175,73]	-3	hSpCas9	negative selection	5175791
193614826	193614848	3	-	27760321	HT29	viability after 13 days	GTCGTTGAAGCTTTAAGGTAGG	OPA1	ENSG00000198836	-1.1319670567203648	[208,162]	[98,74,119]	-7	hSpCas9	negative selection	5259251
193643034	193643056	3	+	27760321	HT29	viability after 13 days	TACCGTTAGCCCTGAGGTAAGG	OPA1	ENSG00000198836	0.1489995859690545	[310,242]	[545,293,235]	1	hSpCas9	negative selection	5259252
193637250	193637272	3	-	27760321	HT29	viability after 13 days	TGATCTTGCGTATTATAACTGG	OPA1	ENSG00000198836	-3.1345460853572034	[16,12]	[0,3,0]	-9	hSpCas9	negative selection	5259253
193638010	193638032	3	+	27760321	HT29	viability after 13 days	AAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	0.1658397061461494	[172,134]	[189,325,91]	2	hSpCas9	negative selection	5259254
193614826	193614848	3	-	27760321	HT29	viability after 10 days	GTCGTTGAAGCTTTAAGGTAGG	OPA1	ENSG00000198836	-0.06158517025114352	[208,162]	[282,104,274]	-1	hSpCas9	negative selection	5342714
193643034	193643056	3	+	27760321	HT29	viability after 10 days	TACCGTTAGCCCTGAGGTAAGG	OPA1	ENSG00000198836	0.03575565177959178	[310,242]	[433,326,302]	0	hSpCas9	negative selection	5342715
193637250	193637272	3	-	27760321	HT29	viability after 10 days	TGATCTTGCGTATTATAACTGG	OPA1	ENSG00000198836	-2.661357296018684	[16,12]	[1,5,0]	-9	hSpCas9	negative selection	5342716
193638010	193638032	3	+	27760321	HT29	viability after 10 days	AAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	0.09075600723862043	[172,134]	[224,290,102]	1	hSpCas9	negative selection	5342717
193614826	193614848	3	-	27760321	MOLM13	viability	GTCGTTGAAGCTTTAAGGTAGG	OPA1	ENSG00000198836	0.7091535175845782	[202,208]	[259,131]	5	hSpCas9	negative selection	5426177
193643034	193643056	3	+	27760321	MOLM13	viability	TACCGTTAGCCCTGAGGTAAGG	OPA1	ENSG00000198836	1.368536327525626	[431,310]	[592,486]	8	hSpCas9	negative selection	5426178
193637250	193637272	3	-	27760321	MOLM13	viability	TGATCTTGCGTATTATAACTGG	OPA1	ENSG00000198836	0.4570392936030858	[14,16]	[25,0]	3	hSpCas9	negative selection	5426179
193638010	193638032	3	+	27760321	MOLM13	viability	AAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	1.297439418753443	[182,172]	[440,81]	8	hSpCas9	negative selection	5426180
193593328	193593351	3	+	27661255	K562	viability	GGGCTCCCGCGTGGCCGTCTCGG	OPA1	ENSG00000198836	-0.7344945334595689	[584,658]	[277,314]	-8	dCas9-KRAB	negative selection	5498381
193593383	193593406	3	+	27661255	K562	viability	GCGACTACGTCGGGCCGCTGTGG	OPA1	ENSG00000198836	-1.3889555648385148	[923,802]	[276,252]	-9	dCas9-KRAB	negative selection	5498382
193593202	193593225	3	-	27661255	K562	viability	GACTTCCGCAAGAGCCTGACAGG	OPA1	ENSG00000198836	-1.5688646743768506	[781,802]	[195,227]	-9	dCas9-KRAB	negative selection	5498383
193593249	193593272	3	-	27661255	K562	viability	GCAGCAAGGGCACAGAGCCGCGG	OPA1	ENSG00000198836	-0.07787999957099731	[889,902]	[734,629]	-3	dCas9-KRAB	negative selection	5498384
193593262	193593285	3	-	27661255	K562	viability	GAAGTGGCCCTCAGCAGCAAGGG	OPA1	ENSG00000198836	-1.090700063319264	[1878,1999]	[839,629]	-8	dCas9-KRAB	negative selection	5498385
193615702	193615725	3	+	27260156	BXPC3	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.20025075493981082	[254]	[272,291,344,319]	4	hSpCas9	negative selection	5559517
193615749	193615772	3	+	27260156	BXPC3	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.2253333420175485	[1039]	[1197,1234,1193,1483]	5	hSpCas9	negative selection	5559518
193635417	193635440	3	+	27260156	BXPC3	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	-0.2111473680682373	[690]	[468,711,585,751]	-5	hSpCas9	negative selection	5559519
193635501	193635524	3	+	27260156	BXPC3	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.12550821645165117	[340]	[356,339,441,425]	2	hSpCas9	negative selection	5623774
193631635	193631658	3	-	27260156	BXPC3	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.15657482529226852	[179]	[174,203,241,222]	3	hSpCas9	negative selection	5623775
193631623	193631646	3	+	27260156	BXPC3	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.15346395669876267	[265]	[255,233,257,250]	-4	hSpCas9	negative selection	5623776
193615702	193615725	3	+	27260156	A673	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	-0.05496192186273052	[254]	[298,258,304,317]	-1	hSpCas9	negative selection	5680768
193615749	193615772	3	+	27260156	A673	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.03384063937403581	[1039]	[1356,1245,1141,1382]	0	hSpCas9	negative selection	5680769
193635417	193635440	3	+	27260156	A673	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	-0.02086924828447112	[690]	[966,727,724,872]	0	hSpCas9	negative selection	5680770
193635501	193635524	3	+	27260156	A673	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.1950959414384527	[340]	[452,443,440,538]	4	hSpCas9	negative selection	5745025
193631635	193631658	3	-	27260156	A673	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.17762772795898618	[179]	[293,229,224,233]	4	hSpCas9	negative selection	5745026
193631623	193631646	3	+	27260156	A673	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.1678888500976844	[265]	[327,196,341,275]	-4	hSpCas9	negative selection	5745027
193615702	193615725	3	+	27260156	A375	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.26059100489978726	[254]	[264,410,522,246]	4	hSpCas9	negative selection	5802019
193615749	193615772	3	+	27260156	A375	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.3487750926954123	[1039]	[1654,1945,1543,1141]	5	hSpCas9	negative selection	5802020
193635417	193635440	3	+	27260156	A375	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	-0.41437641945100784	[690]	[568,655,727,487]	-5	hSpCas9	negative selection	5802021
193635501	193635524	3	+	27260156	A375	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.539334045077827	[340]	[551,664,585,527]	7	hSpCas9	negative selection	5866276
193631635	193631658	3	-	27260156	A375	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	-0.03306756044680714	[179]	[157,268,200,201]	0	hSpCas9	negative selection	5866277
193631623	193631646	3	+	27260156	A375	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.22297279692326566	[265]	[193,425,222,244]	-3	hSpCas9	negative selection	5866278
193615702	193615725	3	+	27260156	COLO741	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.10136214000019195	[254]	[474,258,325]	2	hSpCas9	negative selection	5923270
193615749	193615772	3	+	27260156	COLO741	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.18970590111368568	[1039]	[1538,1264,1724]	4	hSpCas9	negative selection	5923271
193635417	193635440	3	+	27260156	COLO741	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	0.019670355104351778	[690]	[975,710,994]	0	hSpCas9	negative selection	5923272
193635501	193635524	3	+	27260156	COLO741	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.2109066532784717	[340]	[459,542,504]	4	hSpCas9	negative selection	5987527
193631635	193631658	3	-	27260156	COLO741	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.24647750017574266	[179]	[326,286,212]	5	hSpCas9	negative selection	5987528
193631623	193631646	3	+	27260156	COLO741	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.06998447152534226	[265]	[390,286,299]	-1	hSpCas9	negative selection	5987529
193615702	193615725	3	+	27260156	CAL120	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.594312868013825	[254]	[512,498,430]	8	hSpCas9	negative selection	6044521
193615749	193615772	3	+	27260156	CAL120	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.14132693682102926	[1039]	[1663,1332,1321]	2	hSpCas9	negative selection	6044522
193635417	193635440	3	+	27260156	CAL120	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	-0.15738193792714789	[690]	[715,849,738]	-2	hSpCas9	negative selection	6044523
193635501	193635524	3	+	27260156	CAL120	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.4784807546978174	[340]	[612,701,463]	7	hSpCas9	negative selection	6108778
193631635	193631658	3	-	27260156	CAL120	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	-0.05968819385208257	[179]	[384,112,172]	-1	hSpCas9	negative selection	6108779
193631623	193631646	3	+	27260156	CAL120	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	0.3830084079699767	[265]	[309,675,292]	6	hSpCas9	negative selection	6108780
193615702	193615725	3	+	27260156	CADOES1	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.035009102526762925	[254]	[335,272,216,141]	0	hSpCas9	negative selection	6165772
193615749	193615772	3	+	27260156	CADOES1	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.23925802342425784	[1039]	[1248,790,1126,1408]	4	hSpCas9	negative selection	6165773
193635417	193635440	3	+	27260156	CADOES1	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	-0.5147948644876164	[690]	[429,419,401,550]	-7	hSpCas9	negative selection	6165774
193635501	193635524	3	+	27260156	CADOES1	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.4769860085395701	[340]	[352,613,364,433]	7	hSpCas9	negative selection	6230029
193631635	193631658	3	-	27260156	CADOES1	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.5697833029768551	[179]	[162,339,251,238]	8	hSpCas9	negative selection	6230030
193631623	193631646	3	+	27260156	CADOES1	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	0.05412360070902833	[265]	[236,159,251,382]	0	hSpCas9	negative selection	6230031
193615702	193615725	3	+	27260156	EWS502	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.3155650085848847	[254]	[324,215,431,380]	5	hSpCas9	negative selection	6287023
193615749	193615772	3	+	27260156	EWS502	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.4097154094402613	[1039]	[1409,1488,1384,1575]	7	hSpCas9	negative selection	6287024
193635417	193635440	3	+	27260156	EWS502	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	-0.5806983222217276	[690]	[545,444,489,467]	-7	hSpCas9	negative selection	6287025
193635501	193635524	3	+	27260156	EWS502	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.41457536275539364	[340]	[372,522,451,594]	7	hSpCas9	negative selection	6351280
193631635	193631658	3	-	27260156	EWS502	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.2030603467051566	[179]	[200,252,198,224]	3	hSpCas9	negative selection	6351281
193631623	193631646	3	+	27260156	EWS502	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	0.020750182734899147	[265]	[292,251,280,318]	0	hSpCas9	negative selection	6351282
193615702	193615725	3	+	27260156	EW8	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.08112513997193649	[254]	[267,156,259,186]	1	hSpCas9	negative selection	6408274
193615749	193615772	3	+	27260156	EW8	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.20302589649965053	[1039]	[1004,1026,923,933]	4	hSpCas9	negative selection	6408275
193635417	193635440	3	+	27260156	EW8	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	-0.23814157612145664	[690]	[412,550,368,575]	-4	hSpCas9	negative selection	6408276
193635501	193635524	3	+	27260156	EW8	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.3191811397101401	[340]	[407,315,230,448]	6	hSpCas9	negative selection	6472531
193631635	193631658	3	-	27260156	EW8	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.37113476724521655	[179]	[170,156,127,305]	6	hSpCas9	negative selection	6472532
193631623	193631646	3	+	27260156	EW8	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.23600314362501817	[265]	[266,211,112,160]	-4	hSpCas9	negative selection	6472533
193615702	193615725	3	+	27260156	CORL105	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.09434257631414278	[254]	[281,188,541,297]	1	hSpCas9	negative selection	6529525
193615749	193615772	3	+	27260156	CORL105	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	-0.028129349471180287	[1039]	[1075,1177,1485,1077]	0	hSpCas9	negative selection	6529526
193635417	193635440	3	+	27260156	CORL105	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	0.07741102026194424	[690]	[769,951,1027,686]	1	hSpCas9	negative selection	6529527
193635501	193635524	3	+	27260156	CORL105	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.016737362181396598	[340]	[320,352,416,523]	0	hSpCas9	negative selection	6593782
193631635	193631658	3	-	27260156	CORL105	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	-0.08370695123129357	[179]	[156,216,239,185]	-1	hSpCas9	negative selection	6593783
193631623	193631646	3	+	27260156	CORL105	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	0.14875430687710767	[265]	[219,344,482,349]	3	hSpCas9	negative selection	6593784
193615702	193615725	3	+	27260156	HS294T	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.18288409991229537	[254]	[64,108,90,201]	2	hSpCas9	negative selection	6650776
193615749	193615772	3	+	27260156	HS294T	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.2540437646675966	[1039]	[542,443,457,463]	3	hSpCas9	negative selection	6650777
193635417	193635440	3	+	27260156	HS294T	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	-0.34873419432593156	[690]	[162,159,260,270]	-5	hSpCas9	negative selection	6650778
193635501	193635524	3	+	27260156	HS294T	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.3720930439955275	[340]	[143,174,146,227]	5	hSpCas9	negative selection	6715033
193631635	193631658	3	-	27260156	HS294T	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	-0.30299579343536176	[179]	[53,64,56,47]	-4	hSpCas9	negative selection	6715034
193631623	193631646	3	+	27260156	HS294T	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.09198060142108844	[265]	[51,127,101,108]	-1	hSpCas9	negative selection	6715035
193615702	193615725	3	+	27260156	HCC44	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.5435550632277754	[254]	[520,488,299,348]	8	hSpCas9	negative selection	6772027
193615749	193615772	3	+	27260156	HCC44	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.028995155490268543	[1039]	[1170,750,1787,1241]	0	hSpCas9	negative selection	6772028
193635417	193635440	3	+	27260156	HCC44	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	-0.22530243122675575	[690]	[724,597,833,558]	-4	hSpCas9	negative selection	6772029
193635501	193635524	3	+	27260156	HCC44	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.33900929640621014	[340]	[321,462,522,628]	5	hSpCas9	negative selection	6836284
193631635	193631658	3	-	27260156	HCC44	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.05243331880691238	[179]	[227,129,143,337]	0	hSpCas9	negative selection	6836285
193631623	193631646	3	+	27260156	HCC44	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	0.044919069838729286	[265]	[360,281,299,302]	0	hSpCas9	negative selection	6836286
193615702	193615725	3	+	27260156	G402	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.3805169928670582	[254]	[537,421,488,199]	5	hSpCas9	negative selection	6893278
193615749	193615772	3	+	27260156	G402	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.5821688097237494	[1039]	[2102,2279,2051,1240]	7	hSpCas9	negative selection	6893279
193635417	193635440	3	+	27260156	G402	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	0.3747183648704647	[690]	[1281,1081,1228,815]	5	hSpCas9	negative selection	6893280
193635501	193635524	3	+	27260156	G402	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.4835566755242946	[340]	[481,893,464,491]	6	hSpCas9	negative selection	6957535
193631635	193631658	3	-	27260156	G402	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.5095705003958492	[179]	[496,265,400,118]	6	hSpCas9	negative selection	6957536
193631623	193631646	3	+	27260156	G402	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	0.5030832077784249	[265]	[396,769,492,199]	6	hSpCas9	negative selection	6957537
193615702	193615725	3	+	27260156	L33	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	-0.045958702067118384	[254]	[253,128,126,216]	-1	hSpCas9	negative selection	7014529
193615749	193615772	3	+	27260156	L33	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.0179100450265548	[1039]	[1197,457,628,892]	0	hSpCas9	negative selection	7014530
193635417	193635440	3	+	27260156	L33	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	0.06909492127579919	[690]	[818,333,350,703]	1	hSpCas9	negative selection	7014531
193635501	193635524	3	+	27260156	L33	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.5011504922953263	[340]	[542,179,335,412]	8	hSpCas9	negative selection	7078786
193631635	193631658	3	-	27260156	L33	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.4499110657628743	[179]	[202,101,192,225]	8	hSpCas9	negative selection	7078787
193631623	193631646	3	+	27260156	L33	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	0.014743656997961319	[265]	[190,107,169,350]	0	hSpCas9	negative selection	7078788
193615702	193615725	3	+	27260156	K562	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.5682440301586631	[254]	[789,189,108,286]	7	hSpCas9	negative selection	7135780
193615749	193615772	3	+	27260156	K562	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.44816396565505845	[1039]	[946,1431,1397,1239]	5	hSpCas9	negative selection	7135781
193635417	193635440	3	+	27260156	K562	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	0.39084488607168866	[690]	[575,1057,539,1008]	5	hSpCas9	negative selection	7135782
193635501	193635524	3	+	27260156	K562	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.8602622882533063	[340]	[939,586,359,363]	9	hSpCas9	negative selection	7200037
193631635	193631658	3	-	27260156	K562	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	-0.22784643442884067	[179]	[93,147,199,103]	-3	hSpCas9	negative selection	7200038
193631623	193631646	3	+	27260156	K562	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	0.01707918081992521	[265]	[169,391,213,186]	0	hSpCas9	negative selection	7200039
193615702	193615725	3	+	27260156	HT29	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.5018925445444733	[254]	[318,438,497,481]	8	hSpCas9	negative selection	7257031
193615749	193615772	3	+	27260156	HT29	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.27421118431074176	[1039]	[1457,1854,1312,1503]	5	hSpCas9	negative selection	7257032
193635417	193635440	3	+	27260156	HT29	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	-0.0026118465999275253	[690]	[1000,759,910,698]	0	hSpCas9	negative selection	7257033
193635501	193635524	3	+	27260156	HT29	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.5563195359963078	[340]	[687,771,511,495]	9	hSpCas9	negative selection	7321288
193631635	193631658	3	-	27260156	HT29	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.48182047838998776	[179]	[370,307,300,251]	8	hSpCas9	negative selection	7321289
193631623	193631646	3	+	27260156	HT29	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.054779578108541616	[265]	[330,278,376,260]	-1	hSpCas9	negative selection	7321290
193615702	193615725	3	+	27260156	MHHES1	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.4384255573143803	[254]	[489,445,377,277]	7	hSpCas9	negative selection	7378282
193615749	193615772	3	+	27260156	MHHES1	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.3019481643948081	[1039]	[1558,1554,1405,1284]	5	hSpCas9	negative selection	7378283
193635417	193635440	3	+	27260156	MHHES1	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	-0.691165126747151	[690]	[506,374,669,381]	-8	hSpCas9	negative selection	7378284
193635501	193635524	3	+	27260156	MHHES1	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.11843241308486474	[340]	[483,510,350,345]	2	hSpCas9	negative selection	7442539
193631635	193631658	3	-	27260156	MHHES1	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.2391584060493992	[179]	[324,159,174,282]	4	hSpCas9	negative selection	7442540
193631623	193631646	3	+	27260156	MHHES1	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.22804133599525966	[265]	[288,179,163,355]	-4	hSpCas9	negative selection	7442541
193615702	193615725	3	+	27260156	MEWO	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	-0.02364730463490261	[254]	[345,148,230]	0	hSpCas9	negative selection	7499533
193615749	193615772	3	+	27260156	MEWO	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.05012065674905952	[1039]	[923,958,1122]	1	hSpCas9	negative selection	7499534
193635417	193635440	3	+	27260156	MEWO	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	0.15517258165601255	[690]	[754,574,836]	3	hSpCas9	negative selection	7499535
193635501	193635524	3	+	27260156	MEWO	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.1907632170951717	[340]	[357,386,345]	4	hSpCas9	negative selection	7563790
193631635	193631658	3	-	27260156	MEWO	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.3047930442393403	[179]	[259,222,150]	6	hSpCas9	negative selection	7563791
193631623	193631646	3	+	27260156	MEWO	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.36480173506697244	[265]	[213,141,227]	-7	hSpCas9	negative selection	7563792
193615702	193615725	3	+	27260156	LNCAPCLONEFGC	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.024940047557615252	[254]	[217,262,265,195]	0	hSpCas9	negative selection	7620784
193615749	193615772	3	+	27260156	LNCAPCLONEFGC	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.23708570315072386	[1039]	[1173,978,1331,995]	3	hSpCas9	negative selection	7620785
193635417	193635440	3	+	27260156	LNCAPCLONEFGC	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	-0.40245202505186695	[690]	[386,466,627,436]	-6	hSpCas9	negative selection	7620786
193635501	193635524	3	+	27260156	LNCAPCLONEFGC	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.3539472405102902	[340]	[484,323,476,307]	5	hSpCas9	negative selection	7685041
193631635	193631658	3	-	27260156	LNCAPCLONEFGC	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.08812090614075152	[179]	[189,156,193,155]	1	hSpCas9	negative selection	7685042
193631623	193631646	3	+	27260156	LNCAPCLONEFGC	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.6589022225316826	[265]	[182,89,186,158]	-7	hSpCas9	negative selection	7685043
193615702	193615725	3	+	27260156	PANC0327	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.31579955069821564	[254]	[334,305,280,206]	5	hSpCas9	negative selection	7742035
193615749	193615772	3	+	27260156	PANC0327	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.28013891066513263	[1039]	[1477,734,1099,1252]	4	hSpCas9	negative selection	7742036
193635417	193635440	3	+	27260156	PANC0327	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	-0.029490671996919016	[690]	[572,314,671,879]	0	hSpCas9	negative selection	7742037
193635501	193635524	3	+	27260156	PANC0327	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.6276795717417176	[340]	[397,348,701,432]	8	hSpCas9	negative selection	7806292
193631635	193631658	3	-	27260156	PANC0327	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.061781246228440834	[179]	[95,135,325,107]	0	hSpCas9	negative selection	7806293
193631623	193631646	3	+	27260156	PANC0327	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.3962692504661197	[265]	[266,196,144,113]	-5	hSpCas9	negative selection	7806294
193615702	193615725	3	+	27260156	NCIH2009	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.22753621996637374	[254]	[489,312,463]	3	hSpCas9	negative selection	7863286
193615749	193615772	3	+	27260156	NCIH2009	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.17201719272295324	[1039]	[2042,1669,1274]	2	hSpCas9	negative selection	7863287
193635417	193635440	3	+	27260156	NCIH2009	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	-0.9133827459746453	[690]	[666,369,532]	-8	hSpCas9	negative selection	7863288
193635501	193635524	3	+	27260156	NCIH2009	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.5331457383122538	[340]	[933,494,689]	7	hSpCas9	negative selection	7927543
193631635	193631658	3	-	27260156	NCIH2009	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	-0.17434969522798172	[179]	[173,307,174]	-2	hSpCas9	negative selection	7927544
193631623	193631646	3	+	27260156	NCIH2009	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.6081984180164205	[265]	[303,182,256]	-6	hSpCas9	negative selection	7927545
193615702	193615725	3	+	27260156	NCIH1373	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	1.2127560800799617	[254]	[1404,287,392,190]	9	hSpCas9	negative selection	7984537
193615749	193615772	3	+	27260156	NCIH1373	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.26524325120045766	[1039]	[1589,1433,1299,339]	2	hSpCas9	negative selection	7984538
193635417	193635440	3	+	27260156	NCIH1373	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	-0.4764898978559394	[690]	[899,256,592,146]	-5	hSpCas9	negative selection	7984539
193635501	193635524	3	+	27260156	NCIH1373	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.9847571516457929	[340]	[650,686,556,300]	8	hSpCas9	negative selection	8048794
193631635	193631658	3	-	27260156	NCIH1373	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.1073678688002484	[179]	[180,152,109,115]	1	hSpCas9	negative selection	8048795
193631623	193631646	3	+	27260156	NCIH1373	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.6159007235147907	[265]	[196,141,213,60]	-6	hSpCas9	negative selection	8048796
193615702	193615725	3	+	27260156	PATU8902	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.9543801791127398	[254]	[404,674,608,1135]	8	hSpCas9	negative selection	8105788
193615749	193615772	3	+	27260156	PATU8902	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.42700093834531283	[1039]	[2132,1930,1567,2276]	4	hSpCas9	negative selection	8105789
193635417	193635440	3	+	27260156	PATU8902	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	-0.659771029260334	[690]	[999,504,341,653]	-6	hSpCas9	negative selection	8105790
193635501	193635524	3	+	27260156	PATU8902	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.38311661526928437	[340]	[683,739,579,458]	4	hSpCas9	negative selection	8170045
193631635	193631658	3	-	27260156	PATU8902	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	-0.03936494450569761	[179]	[340,205,136,325]	0	hSpCas9	negative selection	8170046
193631623	193631646	3	+	27260156	PATU8902	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	0.19379479305368652	[265]	[386,484,375,460]	2	hSpCas9	negative selection	8170047
193615702	193615725	3	+	27260156	PANC1	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.4526302883304549	[254]	[195,510,317,226]	7	hSpCas9	negative selection	8227039
193615749	193615772	3	+	27260156	PANC1	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.3792261860995225	[1039]	[1192,1570,1000,975]	6	hSpCas9	negative selection	8227040
193635417	193635440	3	+	27260156	PANC1	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	0.0533737476047319	[690]	[679,727,704,398]	0	hSpCas9	negative selection	8227041
193635501	193635524	3	+	27260156	PANC1	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.6261293048746923	[340]	[426,504,448,433]	8	hSpCas9	negative selection	8291296
193631635	193631658	3	-	27260156	PANC1	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.6083643177492468	[179]	[160,229,425,139]	8	hSpCas9	negative selection	8291297
193631623	193631646	3	+	27260156	PANC1	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	0.3375044856791246	[265]	[253,372,392,168]	5	hSpCas9	negative selection	8291298
193615702	193615725	3	+	27260156	PANC0813	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.23836643630606258	[254]	[372,288,332,415]	4	hSpCas9	negative selection	8348290
193615749	193615772	3	+	27260156	PANC0813	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.1802517759788329	[1039]	[1474,1180,1595,1296]	3	hSpCas9	negative selection	8348291
193635417	193635440	3	+	27260156	PANC0813	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	-0.425178918510686	[690]	[647,732,638,411]	-6	hSpCas9	negative selection	8348292
193635501	193635524	3	+	27260156	PANC0813	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.657812053103522	[340]	[712,702,545,574]	9	hSpCas9	negative selection	8412547
193631635	193631658	3	-	27260156	PANC0813	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.051257463919603063	[179]	[216,262,252,146]	0	hSpCas9	negative selection	8412548
193631623	193631646	3	+	27260156	PANC0813	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.46613927479445916	[265]	[316,282,187,129]	-6	hSpCas9	negative selection	8412549
193615702	193615725	3	+	27260156	RDES	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.39067642804940916	[254]	[302,381,401,470]	6	hSpCas9	negative selection	8469541
193615749	193615772	3	+	27260156	RDES	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.36371038647145726	[1039]	[1288,1301,1778,1876]	6	hSpCas9	negative selection	8469542
193635417	193635440	3	+	27260156	RDES	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	0.013595914818809063	[690]	[618,757,829,1062]	0	hSpCas9	negative selection	8469543
193635501	193635524	3	+	27260156	RDES	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.4365261623849397	[340]	[378,620,594,539]	7	hSpCas9	negative selection	8533798
193631635	193631658	3	-	27260156	RDES	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.2385986648529308	[179]	[228,208,262,280]	4	hSpCas9	negative selection	8533799
193631623	193631646	3	+	27260156	RDES	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	0.012268639122698155	[265]	[263,190,385,425]	0	hSpCas9	negative selection	8533800
193615702	193615725	3	+	27260156	PC3	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	-0.04442595636014712	[254]	[183,262,351,224]	-1	hSpCas9	negative selection	8590792
193615749	193615772	3	+	27260156	PC3	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.0817974616613848	[1039]	[939,928,1585,1058]	1	hSpCas9	negative selection	8590793
193635417	193635440	3	+	27260156	PC3	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	0.3069917028177075	[690]	[553,783,1370,954]	6	hSpCas9	negative selection	8590794
193635501	193635524	3	+	27260156	PC3	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.2959243819221335	[340]	[260,370,625,527]	6	hSpCas9	negative selection	8655049
193631635	193631658	3	-	27260156	PC3	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.06762256603347017	[179]	[92,157,441,186]	1	hSpCas9	negative selection	8655050
193631623	193631646	3	+	27260156	PC3	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	0.03835136033182507	[265]	[178,207,678,195]	0	hSpCas9	negative selection	8655051
193615702	193615725	3	+	27260156	PATU8988T	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.12650920330143278	[254]	[144,224,298,413]	2	hSpCas9	negative selection	8712043
193615749	193615772	3	+	27260156	PATU8988T	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.21615739956249658	[1039]	[1002,1114,1263,1290]	4	hSpCas9	negative selection	8712044
193635417	193635440	3	+	27260156	PATU8988T	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	-0.19625291052561217	[690]	[407,800,596,541]	-3	hSpCas9	negative selection	8712045
193635501	193635524	3	+	27260156	PATU8988T	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.4318416001648592	[340]	[658,399,351,356]	7	hSpCas9	negative selection	8776300
193631635	193631658	3	-	27260156	PATU8988T	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	-0.28781335844740763	[179]	[118,204,91,161]	-5	hSpCas9	negative selection	8776301
193631623	193631646	3	+	27260156	PATU8988T	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.4744015498176345	[265]	[193,181,166,197]	-6	hSpCas9	negative selection	8776302
193615702	193615725	3	+	27260156	T47D	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.10913907956389723	[254]	[292,369,243,372]	2	hSpCas9	negative selection	8833294
193615749	193615772	3	+	27260156	T47D	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.26218952015794517	[1039]	[1335,1471,1446,1557]	5	hSpCas9	negative selection	8833295
193635417	193635440	3	+	27260156	T47D	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	0.12102048488626826	[690]	[798,863,957,879]	2	hSpCas9	negative selection	8833296
193635501	193635524	3	+	27260156	T47D	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.5050992590804891	[340]	[555,568,534,595]	9	hSpCas9	negative selection	8897551
193631635	193631658	3	-	27260156	T47D	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.5042704224712377	[179]	[311,336,263,272]	9	hSpCas9	negative selection	8897552
193631623	193631646	3	+	27260156	T47D	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.102614288703616	[265]	[272,248,301,334]	-2	hSpCas9	negative selection	8897553
193615702	193615725	3	+	27260156	SU8686	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.37747027550318735	[254]	[314,244,336,445]	6	hSpCas9	negative selection	8954545
193615749	193615772	3	+	27260156	SU8686	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.2938234081004043	[1039]	[1088,1076,1238,1766]	5	hSpCas9	negative selection	8954546
193635417	193635440	3	+	27260156	SU8686	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	-0.3726266578155113	[690]	[562,475,579,491]	-6	hSpCas9	negative selection	8954547
193635501	193635524	3	+	27260156	SU8686	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.9300177868680124	[340]	[482,540,862,737]	9	hSpCas9	negative selection	9018802
193631635	193631658	3	-	27260156	SU8686	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	-0.07118881810027178	[179]	[133,136,177,250]	-1	hSpCas9	negative selection	9018803
193631623	193631646	3	+	27260156	SU8686	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.18271104506181268	[265]	[206,177,354,194]	-3	hSpCas9	negative selection	9018804
193615702	193615725	3	+	27260156	SKES1	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.027499046358471446	[254]	[464,226,161,211]	0	hSpCas9	negative selection	9075796
193615749	193615772	3	+	27260156	SKES1	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.19475947495452073	[1039]	[1356,1207,1041,1160]	4	hSpCas9	negative selection	9075797
193635417	193635440	3	+	27260156	SKES1	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	-0.23596134050760398	[690]	[598,813,490,474]	-5	hSpCas9	negative selection	9075798
193635501	193635524	3	+	27260156	SKES1	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.22263365048660344	[340]	[517,498,313,294]	5	hSpCas9	negative selection	9140053
193631635	193631658	3	-	27260156	SKES1	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.46973401242103474	[179]	[292,267,209,231]	8	hSpCas9	negative selection	9140054
193631623	193631646	3	+	27260156	SKES1	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.06862777628635475	[265]	[241,353,243,187]	-1	hSpCas9	negative selection	9140055
193615702	193615725	3	+	27260156	TOV112D	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	-0.040587443745649265	[254]	[444,103,325,102]	-1	hSpCas9	negative selection	9197047
193615749	193615772	3	+	27260156	TOV112D	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.2601146723280672	[1039]	[1338,1289,1246,1132]	5	hSpCas9	negative selection	9197048
193635417	193635440	3	+	27260156	TOV112D	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	-0.21044500841672814	[690]	[557,865,500,530]	-4	hSpCas9	negative selection	9197049
193635501	193635524	3	+	27260156	TOV112D	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	-0.0372120747743549	[340]	[280,419,318,327]	0	hSpCas9	negative selection	9261304
193631635	193631658	3	-	27260156	TOV112D	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.5846191318718218	[179]	[179,445,198,290]	9	hSpCas9	negative selection	9261305
193631623	193631646	3	+	27260156	TOV112D	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.1348704483344092	[265]	[395,218,110,250]	-3	hSpCas9	negative selection	9261306
193615702	193615725	3	+	27260156	TC71	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	-0.16268911394813712	[254]	[224,248,205,301]	-4	hSpCas9	negative selection	9318298
193615749	193615772	3	+	27260156	TC71	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	-0.0313304462553754	[1039]	[1047,1184,951,1189]	-1	hSpCas9	negative selection	9318299
193635417	193635440	3	+	27260156	TC71	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	0.0003232161349034923	[690]	[842,739,654,724]	0	hSpCas9	negative selection	9318300
193635501	193635524	3	+	27260156	TC71	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.35277476315952855	[340]	[436,435,424,577]	8	hSpCas9	negative selection	9382555
193631635	193631658	3	-	27260156	TC71	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.07009171220919641	[179]	[150,207,216,236]	1	hSpCas9	negative selection	9382556
193631623	193631646	3	+	27260156	TC71	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.1497469410722213	[265]	[189,298,279,259]	-4	hSpCas9	negative selection	9382557
193615702	193615725	3	+	27260156	TC32	viability	CGGACCTTAGTGAATATAAATGG	OPA1	ENSG00000198836	0.2638390992996683	[254]	[266,225,344,333]	5	hSpCas9	negative selection	9439549
193615749	193615772	3	+	27260156	TC32	viability	ATTGATGAGTATATCGATTTTGG	OPA1	ENSG00000198836	0.22385101230367788	[1039]	[928,1037,1316,1316]	4	hSpCas9	negative selection	9439550
193635417	193635440	3	+	27260156	TC32	viability	GTTGAAGTATCAGAGAATCTTGG	OPA1	ENSG00000198836	-0.39514757747057194	[690]	[479,462,454,554]	-6	hSpCas9	negative selection	9439551
193635501	193635524	3	+	27260156	TC32	viability	CATTCATCATAGAAAGCTTAAGG	OPA1	ENSG00000198836	0.32043676507815966	[340]	[425,181,534,546]	5	hSpCas9	negative selection	9503806
193631635	193631658	3	-	27260156	TC32	viability	GCAGAAGTTCTTCCTGAAGTTGG	OPA1	ENSG00000198836	0.11553639276438421	[179]	[159,167,156,243]	2	hSpCas9	negative selection	9503807
193631623	193631646	3	+	27260156	TC32	viability	AGAGAAAATTGACCAACTTCAGG	OPA1	ENSG00000198836	-0.016042648483526212	[265]	[255,146,348,278]	0	hSpCas9	negative selection	9503808
193637260	193637283	3	+	27869803	HPAFII	viability after 27 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	-5.701776165703906	[98]	[0,0,NaN]	-9	hSpCas9	negative selection	9584058
193638009	193638032	3	+	27869803	HPAFII	viability after 27 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-3.405587391615421	[327]	[0,28,NaN]	-9	hSpCas9	negative selection	9584059
193647143	193647166	3	+	27869803	HPAFII	viability after 27 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	1.984571441279378	[228]	[476,475,NaN]	9	hSpCas9	negative selection	9584060
193648113	193648136	3	+	27869803	HPAFII	viability after 27 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	-3.8509196050097154	[251]	[18,0,NaN]	-9	hSpCas9	negative selection	9584061
193654929	193654952	3	-	27869803	HPAFII	viability after 27 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	-1.1908142464265268	[44]	[17,3,NaN]	-7	hSpCas9	negative selection	9584062
193637260	193637283	3	+	27869803	HPAFII	viability after 15 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	-6.733330903833778	[98]	[0,0,NaN]	-9	hSpCas9	negative selection	9666507
193638009	193638032	3	+	27869803	HPAFII	viability after 15 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-3.4119663260286814	[327]	[50,21,NaN]	-9	hSpCas9	negative selection	9666508
193647143	193647166	3	+	27869803	HPAFII	viability after 15 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	1.511273822548936	[228]	[954,543,NaN]	9	hSpCas9	negative selection	9666509
193648113	193648136	3	+	27869803	HPAFII	viability after 15 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	-2.0137200781774953	[251]	[71,63,NaN]	-9	hSpCas9	negative selection	9666510
193654929	193654952	3	-	27869803	HPAFII	viability after 15 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	-0.11084440830717357	[44]	[74,25,NaN]	-1	hSpCas9	negative selection	9666511
193637260	193637283	3	+	27869803	ASPC1	viability after 36 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	-0.40402313916850074	[182]	[0,119,23]	-4	hSpCas9	negative selection	9748956
193638009	193638032	3	+	27869803	ASPC1	viability after 36 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-2.876964356312267	[753]	[16,47,38]	-9	hSpCas9	negative selection	9748957
193647143	193647166	3	+	27869803	ASPC1	viability after 36 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	1.141717307619312	[820]	[881,433,607]	9	hSpCas9	negative selection	9748958
193648113	193648136	3	+	27869803	ASPC1	viability after 36 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	-2.540709259373906	[526]	[23,44,25]	-9	hSpCas9	negative selection	9748959
193654929	193654952	3	-	27869803	ASPC1	viability after 36 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	-1.2865026685045964	[204]	[36,9,38]	-8	hSpCas9	negative selection	9748960
193637260	193637283	3	+	27869803	PATU8988S	viability after 35 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	-5.213492321445393	[229]	[0,3,NaN]	-9	hSpCas9	negative selection	9831405
193638009	193638032	3	+	27869803	PATU8988S	viability after 35 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-2.9043792262324573	[714]	[21,54,NaN]	-9	hSpCas9	negative selection	9831406
193647143	193647166	3	+	27869803	PATU8988S	viability after 35 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	-0.13207714866506653	[738]	[312,229,NaN]	-1	hSpCas9	negative selection	9831407
193648113	193648136	3	+	27869803	PATU8988S	viability after 35 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	-2.0821994572940556	[462]	[59,27,NaN]	-9	hSpCas9	negative selection	9831408
193654929	193654952	3	-	27869803	PATU8988S	viability after 35 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	-0.6245054210229299	[110]	[27,29,NaN]	-6	hSpCas9	negative selection	9831409
193637260	193637283	3	+	27869803	PATU8988S	viability after 31 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	-3.162827934278891	[229]	[11,7,NaN]	-9	hSpCas9	negative selection	9913854
193638009	193638032	3	+	27869803	PATU8988S	viability after 31 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-2.3065744754374617	[714]	[10,116,NaN]	-9	hSpCas9	negative selection	9913855
193647143	193647166	3	+	27869803	PATU8988S	viability after 31 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	-0.4108334040493397	[738]	[262,168,NaN]	-4	hSpCas9	negative selection	9913856
193648113	193648136	3	+	27869803	PATU8988S	viability after 31 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	-0.8600870099571128	[462]	[51,164,NaN]	-7	hSpCas9	negative selection	9913857
193654929	193654952	3	-	27869803	PATU8988S	viability after 31 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	-0.47153123209466674	[110]	[34,27,NaN]	-5	hSpCas9	negative selection	9913858
193637260	193637283	3	+	27869803	HPAFII	viability after 35 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	-5.647268067082935	[98]	[0,0,NaN]	-9	hSpCas9	negative selection	9996303
193638009	193638032	3	+	27869803	HPAFII	viability after 35 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-4.1326470856921755	[327]	[0,18,NaN]	-9	hSpCas9	negative selection	9996304
193647143	193647166	3	+	27869803	HPAFII	viability after 35 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	2.2878653661707364	[228]	[583,545,NaN]	9	hSpCas9	negative selection	9996305
193648113	193648136	3	+	27869803	HPAFII	viability after 35 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	-5.354303455184093	[251]	[4,0,NaN]	-9	hSpCas9	negative selection	9996306
193654929	193654952	3	-	27869803	HPAFII	viability after 35 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	1.3558648224020282	[44]	[86,25,NaN]	8	hSpCas9	negative selection	9996307
193637260	193637283	3	+	27869803	HPAFII	viability after 31 days	TACGCAAGATCATCTGCCACGGG	OPA1	ENSG00000198836	-5.795985420404352	[98]	[0,0,NaN]	-9	hSpCas9	negative selection	10078752
193638009	193638032	3	+	27869803	HPAFII	viability after 31 days	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-4.671896539984777	[327]	[0,13,NaN]	-9	hSpCas9	negative selection	10078753
193647143	193647166	3	+	27869803	HPAFII	viability after 31 days	ACGAGAGTCTGTTGAACAACAGG	OPA1	ENSG00000198836	2.2357250251692453	[228]	[645,560,NaN]	9	hSpCas9	negative selection	10078754
193648113	193648136	3	+	27869803	HPAFII	viability after 31 days	TCGCCTGCGGGAACTTGACCGGG	OPA1	ENSG00000198836	-5.518304238606157	[251]	[4,0,NaN]	-9	hSpCas9	negative selection	10078755
193654929	193654952	3	-	27869803	HPAFII	viability after 31 days	GAATTCATGGTCTGCGCAGCTGG	OPA1	ENSG00000198836	0.05379943413119159	[44]	[30,20,NaN]	0	hSpCas9	negative selection	10078756
193657202	193657225	3	+	28162770	P31FUJ	viability	CAAGTGGAATGACTTTGCGGAGG	OPA1	ENSG00000198836	-0.4172267755518062	[99]	[87]	-4	hSpCas9	negative selection	10204769
193638009	193638032	3	+	28162770	P31FUJ	viability	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-1.0572306398309244	[84]	[47]	-6	hSpCas9	negative selection	10204770
193637259	193637282	3	+	28162770	P31FUJ	viability	ATACGCAAGATCATCTGCCACGG	OPA1	ENSG00000198836	-1.9164489799949418	[362]	[112]	-8	hSpCas9	negative selection	10204771
193654952	193654975	3	+	28162770	P31FUJ	viability	AGGAACTTTTAACACCACAGTGG	OPA1	ENSG00000198836	-3.1006986684070332	[72]	[9]	-9	hSpCas9	negative selection	10204772
193659540	193659563	3	+	28162770	P31FUJ	viability	GAAGAATCGGACCCAAGAACAGG	OPA1	ENSG00000198836	-2.2010933446870404	[89]	[22]	-8	hSpCas9	negative selection	10204773
193643389	193643412	3	+	28162770	P31FUJ	viability	TAAAAGGCCCTGGACTACAGAGG	OPA1	ENSG00000198836	-2.3351639220440563	[291]	[67]	-8	hSpCas9	negative selection	10204774
193648116	193648139	3	-	28162770	P31FUJ	viability	TTACCCGGTCAAGTTCCCGCAGG	OPA1	ENSG00000198836	-2.434436065584029	[275]	[59]	-8	hSpCas9	negative selection	10204775
193666292	193666315	3	+	28162770	P31FUJ	viability	TCAGTTGGAATGCAATGATGTGG	OPA1	ENSG00000198836	-2.393038149688257	[741]	[165]	-8	hSpCas9	negative selection	10204776
193593383	193593406	3	+	28162770	P31FUJ	viability	GCGACTACGTCGGGCCGCTGTGG	OPA1	ENSG00000198836	1.159515218364382	[7]	[20]	9	hSpCas9	negative selection	10204777
193615724	193615747	3	+	28162770	P31FUJ	viability	GATTGTGCCTGACATTGTGTGGG	OPA1	ENSG00000198836	-0.12663664719745063	[274]	[295]	-1	hSpCas9	negative selection	10204778
193657202	193657225	3	+	28162770	TF1	viability	CAAGTGGAATGACTTTGCGGAGG	OPA1	ENSG00000198836	NaN	[NaN]	[14]	1	hSpCas9	negative selection	10374135
193638009	193638032	3	+	28162770	TF1	viability	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	NaN	[NaN]	[0]	1	hSpCas9	negative selection	10374136
193637259	193637282	3	+	28162770	TF1	viability	ATACGCAAGATCATCTGCCACGG	OPA1	ENSG00000198836	NaN	[NaN]	[67]	1	hSpCas9	negative selection	10374137
193654952	193654975	3	+	28162770	TF1	viability	AGGAACTTTTAACACCACAGTGG	OPA1	ENSG00000198836	NaN	[NaN]	[0]	1	hSpCas9	negative selection	10374138
193659540	193659563	3	+	28162770	TF1	viability	GAAGAATCGGACCCAAGAACAGG	OPA1	ENSG00000198836	NaN	[NaN]	[6]	1	hSpCas9	negative selection	10374139
193643389	193643412	3	+	28162770	TF1	viability	TAAAAGGCCCTGGACTACAGAGG	OPA1	ENSG00000198836	NaN	[NaN]	[28]	1	hSpCas9	negative selection	10374140
193648116	193648139	3	-	28162770	TF1	viability	TTACCCGGTCAAGTTCCCGCAGG	OPA1	ENSG00000198836	NaN	[NaN]	[13]	1	hSpCas9	negative selection	10374141
193666292	193666315	3	+	28162770	TF1	viability	TCAGTTGGAATGCAATGATGTGG	OPA1	ENSG00000198836	NaN	[NaN]	[127]	1	hSpCas9	negative selection	10374142
193593383	193593406	3	+	28162770	TF1	viability	GCGACTACGTCGGGCCGCTGTGG	OPA1	ENSG00000198836	NaN	[NaN]	[0]	1	hSpCas9	negative selection	10374143
193615724	193615747	3	+	28162770	TF1	viability	GATTGTGCCTGACATTGTGTGGG	OPA1	ENSG00000198836	NaN	[NaN]	[175]	1	hSpCas9	negative selection	10374144
193657202	193657225	3	+	28162770	SKM1	viability	CAAGTGGAATGACTTTGCGGAGG	OPA1	ENSG00000198836	-0.33657487085176363	[29]	[41]	-3	hSpCas9	negative selection	10543501
193638009	193638032	3	+	28162770	SKM1	viability	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-0.09763614063543291	[22]	[37]	-1	hSpCas9	negative selection	10543502
193637259	193637282	3	+	28162770	SKM1	viability	ATACGCAAGATCATCTGCCACGG	OPA1	ENSG00000198836	-0.5548976278791649	[117]	[141]	-4	hSpCas9	negative selection	10543503
193654952	193654975	3	+	28162770	SKM1	viability	AGGAACTTTTAACACCACAGTGG	OPA1	ENSG00000198836	-0.9740047914670555	[19]	[17]	-6	hSpCas9	negative selection	10543504
193659540	193659563	3	+	28162770	SKM1	viability	GAAGAATCGGACCCAAGAACAGG	OPA1	ENSG00000198836	-0.3875988738762305	[36]	[49]	-3	hSpCas9	negative selection	10543505
193643389	193643412	3	+	28162770	SKM1	viability	TAAAAGGCCCTGGACTACAGAGG	OPA1	ENSG00000198836	-1.709526968763593	[73]	[39]	-8	hSpCas9	negative selection	10543506
193648116	193648139	3	-	28162770	SKM1	viability	TTACCCGGTCAAGTTCCCGCAGG	OPA1	ENSG00000198836	-1.3554338981030796	[54]	[37]	-7	hSpCas9	negative selection	10543507
193666292	193666315	3	+	28162770	SKM1	viability	TCAGTTGGAATGCAATGATGTGG	OPA1	ENSG00000198836	-1.5516439513823528	[130]	[78]	-8	hSpCas9	negative selection	10543508
193593383	193593406	3	+	28162770	SKM1	viability	GCGACTACGTCGGGCCGCTGTGG	OPA1	ENSG00000198836	-0.6520766965796931	[7]	[8]	-5	hSpCas9	negative selection	10543509
193615724	193615747	3	+	28162770	SKM1	viability	GATTGTGCCTGACATTGTGTGGG	OPA1	ENSG00000198836	-0.19956449188218645	[75]	[116]	-2	hSpCas9	negative selection	10543510
193657202	193657225	3	+	28162770	SKM1	viability	CAAGTGGAATGACTTTGCGGAGG	OPA1	ENSG00000198836	-0.33657487085176363	[29]	[41]	-3	hSpCas9	negative selection	10712867
193638009	193638032	3	+	28162770	SKM1	viability	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-0.09763614063543291	[22]	[37]	-1	hSpCas9	negative selection	10712868
193637259	193637282	3	+	28162770	SKM1	viability	ATACGCAAGATCATCTGCCACGG	OPA1	ENSG00000198836	-0.5548976278791649	[117]	[141]	-4	hSpCas9	negative selection	10712869
193654952	193654975	3	+	28162770	SKM1	viability	AGGAACTTTTAACACCACAGTGG	OPA1	ENSG00000198836	-0.9740047914670555	[19]	[17]	-6	hSpCas9	negative selection	10712870
193659540	193659563	3	+	28162770	SKM1	viability	GAAGAATCGGACCCAAGAACAGG	OPA1	ENSG00000198836	-0.3875988738762305	[36]	[49]	-3	hSpCas9	negative selection	10712871
193643389	193643412	3	+	28162770	SKM1	viability	TAAAAGGCCCTGGACTACAGAGG	OPA1	ENSG00000198836	-1.709526968763593	[73]	[39]	-8	hSpCas9	negative selection	10712872
193648116	193648139	3	-	28162770	SKM1	viability	TTACCCGGTCAAGTTCCCGCAGG	OPA1	ENSG00000198836	-1.3554338981030796	[54]	[37]	-7	hSpCas9	negative selection	10712873
193666292	193666315	3	+	28162770	SKM1	viability	TCAGTTGGAATGCAATGATGTGG	OPA1	ENSG00000198836	-1.5516439513823528	[130]	[78]	-8	hSpCas9	negative selection	10712874
193593383	193593406	3	+	28162770	SKM1	viability	GCGACTACGTCGGGCCGCTGTGG	OPA1	ENSG00000198836	-0.6520766965796931	[7]	[8]	-5	hSpCas9	negative selection	10712875
193615724	193615747	3	+	28162770	SKM1	viability	GATTGTGCCTGACATTGTGTGGG	OPA1	ENSG00000198836	-0.19956449188218645	[75]	[116]	-2	hSpCas9	negative selection	10712876
193657202	193657225	3	+	28162770	PL21	viability	CAAGTGGAATGACTTTGCGGAGG	OPA1	ENSG00000198836	-3.455212214123234	[125]	[4]	-9	hSpCas9	negative selection	10882233
193638009	193638032	3	+	28162770	PL21	viability	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-3.4628253982331096	[75]	[2]	-9	hSpCas9	negative selection	10882234
193637259	193637282	3	+	28162770	PL21	viability	ATACGCAAGATCATCTGCCACGG	OPA1	ENSG00000198836	-0.6826990412779307	[460]	[124]	-5	hSpCas9	negative selection	10882235
193654952	193654975	3	+	28162770	PL21	viability	AGGAACTTTTAACACCACAGTGG	OPA1	ENSG00000198836	-3.5724498894076078	[81]	[2]	-9	hSpCas9	negative selection	10882236
193659540	193659563	3	+	28162770	PL21	viability	GAAGAATCGGACCCAAGAACAGG	OPA1	ENSG00000198836	-1.79986038551068	[143]	[17]	-8	hSpCas9	negative selection	10882237
193643389	193643412	3	+	28162770	PL21	viability	TAAAAGGCCCTGGACTACAGAGG	OPA1	ENSG00000198836	-3.5203378568883172	[289]	[10]	-9	hSpCas9	negative selection	10882238
193648116	193648139	3	-	28162770	PL21	viability	TTACCCGGTCAAGTTCCCGCAGG	OPA1	ENSG00000198836	-2.6507169462048705	[201]	[13]	-9	hSpCas9	negative selection	10882239
193666292	193666315	3	+	28162770	PL21	viability	TCAGTTGGAATGCAATGATGTGG	OPA1	ENSG00000198836	-2.769486736467161	[516]	[32]	-9	hSpCas9	negative selection	10882240
193593383	193593406	3	+	28162770	PL21	viability	GCGACTACGTCGGGCCGCTGTGG	OPA1	ENSG00000198836	0.6151771137681643	[8]	[5]	5	hSpCas9	negative selection	10882241
193615724	193615747	3	+	28162770	PL21	viability	GATTGTGCCTGACATTGTGTGGG	OPA1	ENSG00000198836	0.34748133056450725	[185]	[102]	3	hSpCas9	negative selection	10882242
193657202	193657225	3	+	28162770	P31FUJ	viability	CAAGTGGAATGACTTTGCGGAGG	OPA1	ENSG00000198836	-0.4172267755518062	[99]	[87]	-4	hSpCas9	negative selection	11051599
193638009	193638032	3	+	28162770	P31FUJ	viability	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-1.0572306398309244	[84]	[47]	-6	hSpCas9	negative selection	11051600
193637259	193637282	3	+	28162770	P31FUJ	viability	ATACGCAAGATCATCTGCCACGG	OPA1	ENSG00000198836	-1.9164489799949418	[362]	[112]	-8	hSpCas9	negative selection	11051601
193654952	193654975	3	+	28162770	P31FUJ	viability	AGGAACTTTTAACACCACAGTGG	OPA1	ENSG00000198836	-3.1006986684070332	[72]	[9]	-9	hSpCas9	negative selection	11051602
193659540	193659563	3	+	28162770	P31FUJ	viability	GAAGAATCGGACCCAAGAACAGG	OPA1	ENSG00000198836	-2.2010933446870404	[89]	[22]	-8	hSpCas9	negative selection	11051603
193643389	193643412	3	+	28162770	P31FUJ	viability	TAAAAGGCCCTGGACTACAGAGG	OPA1	ENSG00000198836	-2.3351639220440563	[291]	[67]	-8	hSpCas9	negative selection	11051604
193648116	193648139	3	-	28162770	P31FUJ	viability	TTACCCGGTCAAGTTCCCGCAGG	OPA1	ENSG00000198836	-2.434436065584029	[275]	[59]	-8	hSpCas9	negative selection	11051605
193666292	193666315	3	+	28162770	P31FUJ	viability	TCAGTTGGAATGCAATGATGTGG	OPA1	ENSG00000198836	-2.393038149688257	[741]	[165]	-8	hSpCas9	negative selection	11051606
193593383	193593406	3	+	28162770	P31FUJ	viability	GCGACTACGTCGGGCCGCTGTGG	OPA1	ENSG00000198836	1.159515218364382	[7]	[20]	9	hSpCas9	negative selection	11051607
193615724	193615747	3	+	28162770	P31FUJ	viability	GATTGTGCCTGACATTGTGTGGG	OPA1	ENSG00000198836	-0.12663664719745063	[274]	[295]	-1	hSpCas9	negative selection	11051608
193657202	193657225	3	+	28162770	OCIAML5	viability	CAAGTGGAATGACTTTGCGGAGG	OPA1	ENSG00000198836	1.4491029638565678	[13]	[68]	9	hSpCas9	negative selection	11220965
193638009	193638032	3	+	28162770	OCIAML5	viability	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-0.27833132556609486	[42]	[63]	-2	hSpCas9	negative selection	11220966
193637259	193637282	3	+	28162770	OCIAML5	viability	ATACGCAAGATCATCTGCCACGG	OPA1	ENSG00000198836	-0.9977440260596322	[176]	[159]	-6	hSpCas9	negative selection	11220967
193654952	193654975	3	+	28162770	OCIAML5	viability	AGGAACTTTTAACACCACAGTGG	OPA1	ENSG00000198836	-2.5041432674436903	[43]	[13]	-8	hSpCas9	negative selection	11220968
193659540	193659563	3	+	28162770	OCIAML5	viability	GAAGAATCGGACCCAAGAACAGG	OPA1	ENSG00000198836	-2.4894964914792883	[55]	[17]	-8	hSpCas9	negative selection	11220969
193643389	193643412	3	+	28162770	OCIAML5	viability	TAAAAGGCCCTGGACTACAGAGG	OPA1	ENSG00000198836	-0.9561749742047355	[157]	[146]	-5	hSpCas9	negative selection	11220970
193648116	193648139	3	-	28162770	OCIAML5	viability	TTACCCGGTCAAGTTCCCGCAGG	OPA1	ENSG00000198836	-1.897154460392535	[129]	[62]	-7	hSpCas9	negative selection	11220971
193666292	193666315	3	+	28162770	OCIAML5	viability	TCAGTTGGAATGCAATGATGTGG	OPA1	ENSG00000198836	-0.42684769523691823	[352]	[473]	-3	hSpCas9	negative selection	11220972
193593383	193593406	3	+	28162770	OCIAML5	viability	GCGACTACGTCGGGCCGCTGTGG	OPA1	ENSG00000198836	1.7668432617804966	[6]	[42]	9	hSpCas9	negative selection	11220973
193615724	193615747	3	+	28162770	OCIAML5	viability	GATTGTGCCTGACATTGTGTGGG	OPA1	ENSG00000198836	0.08822718301173527	[184]	[354]	0	hSpCas9	negative selection	11220974
193657202	193657225	3	+	28162770	EOL1	viability	CAAGTGGAATGACTTTGCGGAGG	OPA1	ENSG00000198836	-1.083815701364092	[172]	[42]	-6	hSpCas9	negative selection	11390331
193638009	193638032	3	+	28162770	EOL1	viability	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-2.018868700063098	[99]	[12]	-8	hSpCas9	negative selection	11390332
193637259	193637282	3	+	28162770	EOL1	viability	ATACGCAAGATCATCTGCCACGG	OPA1	ENSG00000198836	-1.8492978882968187	[765]	[111]	-8	hSpCas9	negative selection	11390333
193654952	193654975	3	+	28162770	EOL1	viability	AGGAACTTTTAACACCACAGTGG	OPA1	ENSG00000198836	0.08561020430305089	[126]	[70]	0	hSpCas9	negative selection	11390334
193659540	193659563	3	+	28162770	EOL1	viability	GAAGAATCGGACCCAAGAACAGG	OPA1	ENSG00000198836	-2.021004444407089	[207]	[26]	-8	hSpCas9	negative selection	11390335
193643389	193643412	3	+	28162770	EOL1	viability	TAAAAGGCCCTGGACTACAGAGG	OPA1	ENSG00000198836	-2.0901587272444906	[492]	[60]	-8	hSpCas9	negative selection	11390336
193648116	193648139	3	-	28162770	EOL1	viability	TTACCCGGTCAAGTTCCCGCAGG	OPA1	ENSG00000198836	-3.589331631089139	[296]	[12]	-9	hSpCas9	negative selection	11390337
193666292	193666315	3	+	28162770	EOL1	viability	TCAGTTGGAATGCAATGATGTGG	OPA1	ENSG00000198836	-1.8891673152665103	[681]	[96]	-8	hSpCas9	negative selection	11390338
193593383	193593406	3	+	28162770	EOL1	viability	GCGACTACGTCGGGCCGCTGTGG	OPA1	ENSG00000198836	-2.323379741873051	[18]	[1]	-8	hSpCas9	negative selection	11390339
193615724	193615747	3	+	28162770	EOL1	viability	GATTGTGCCTGACATTGTGTGGG	OPA1	ENSG00000198836	-0.5323099034029364	[279]	[101]	-4	hSpCas9	negative selection	11390340
193657202	193657225	3	+	28162770	MOLM13	viability	CAAGTGGAATGACTTTGCGGAGG	OPA1	ENSG00000198836	1.8533204187380994	[159]	[417]	9	hSpCas9	negative selection	11559697
193638009	193638032	3	+	28162770	MOLM13	viability	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-1.3038416307823038	[139]	[40]	-6	hSpCas9	negative selection	11559698
193637259	193637282	3	+	28162770	MOLM13	viability	ATACGCAAGATCATCTGCCACGG	OPA1	ENSG00000198836	0.9204916617917598	[615]	[842]	7	hSpCas9	negative selection	11559699
193654952	193654975	3	+	28162770	MOLM13	viability	AGGAACTTTTAACACCACAGTGG	OPA1	ENSG00000198836	0.7929847555106241	[90]	[113]	6	hSpCas9	negative selection	11559700
193659540	193659563	3	+	28162770	MOLM13	viability	GAAGAATCGGACCCAAGAACAGG	OPA1	ENSG00000198836	1.2346902052515478	[133]	[227]	8	hSpCas9	negative selection	11559701
193643389	193643412	3	+	28162770	MOLM13	viability	TAAAAGGCCCTGGACTACAGAGG	OPA1	ENSG00000198836	1.7497281888164302	[342]	[833]	9	hSpCas9	negative selection	11559702
193648116	193648139	3	-	28162770	MOLM13	viability	TTACCCGGTCAAGTTCCCGCAGG	OPA1	ENSG00000198836	0.060385554951142506	[381]	[287]	0	hSpCas9	negative selection	11559703
193666292	193666315	3	+	28162770	MOLM13	viability	TCAGTTGGAATGCAATGATGTGG	OPA1	ENSG00000198836	1.2546740971194297	[665]	[1148]	8	hSpCas9	negative selection	11559704
193593383	193593406	3	+	28162770	MOLM13	viability	GCGACTACGTCGGGCCGCTGTGG	OPA1	ENSG00000198836	1.285025324394768	[20]	[36]	8	hSpCas9	negative selection	11559705
193615724	193615747	3	+	28162770	MOLM13	viability	GATTGTGCCTGACATTGTGTGGG	OPA1	ENSG00000198836	0.7184328431951759	[289]	[344]	5	hSpCas9	negative selection	11559706
193657202	193657225	3	+	28162770	HEL	viability	CAAGTGGAATGACTTTGCGGAGG	OPA1	ENSG00000198836	-1.698952517708435	[146]	[28]	-7	hSpCas9	negative selection	11729063
193638009	193638032	3	+	28162770	HEL	viability	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-3.231730285915784	[87]	[5]	-9	hSpCas9	negative selection	11729064
193637259	193637282	3	+	28162770	HEL	viability	ATACGCAAGATCATCTGCCACGG	OPA1	ENSG00000198836	-1.6332030576128251	[493]	[101]	-7	hSpCas9	negative selection	11729065
193654952	193654975	3	+	28162770	HEL	viability	AGGAACTTTTAACACCACAGTGG	OPA1	ENSG00000198836	-0.9719710121148513	[97]	[31]	-6	hSpCas9	negative selection	11729066
193659540	193659563	3	+	28162770	HEL	viability	GAAGAATCGGACCCAAGAACAGG	OPA1	ENSG00000198836	-0.6791892628870055	[99]	[39]	-4	hSpCas9	negative selection	11729067
193643389	193643412	3	+	28162770	HEL	viability	TAAAAGGCCCTGGACTACAGAGG	OPA1	ENSG00000198836	-2.121929690955697	[332]	[48]	-8	hSpCas9	negative selection	11729068
193648116	193648139	3	-	28162770	HEL	viability	TTACCCGGTCAAGTTCCCGCAGG	OPA1	ENSG00000198836	-2.2251576319922983	[218]	[29]	-8	hSpCas9	negative selection	11729069
193666292	193666315	3	+	28162770	HEL	viability	TCAGTTGGAATGCAATGATGTGG	OPA1	ENSG00000198836	-2.3641805819394337	[626]	[77]	-8	hSpCas9	negative selection	11729070
193593383	193593406	3	+	28162770	HEL	viability	GCGACTACGTCGGGCCGCTGTGG	OPA1	ENSG00000198836	1.408273578363334	[9]	[16]	9	hSpCas9	negative selection	11729071
193615724	193615747	3	+	28162770	HEL	viability	GATTGTGCCTGACATTGTGTGGG	OPA1	ENSG00000198836	0.5046626965973845	[251]	[228]	4	hSpCas9	negative selection	11729072
193657202	193657225	3	+	28162770	MV411	viability	CAAGTGGAATGACTTTGCGGAGG	OPA1	ENSG00000198836	-1.6138561783856327	[108]	[29]	-7	hSpCas9	negative selection	11898429
193638009	193638032	3	+	28162770	MV411	viability	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-1.011296717617393	[66]	[27]	-6	hSpCas9	negative selection	11898430
193637259	193637282	3	+	28162770	MV411	viability	ATACGCAAGATCATCTGCCACGG	OPA1	ENSG00000198836	-1.6048088287735327	[407]	[112]	-7	hSpCas9	negative selection	11898431
193654952	193654975	3	+	28162770	MV411	viability	AGGAACTTTTAACACCACAGTGG	OPA1	ENSG00000198836	-1.3119898578312437	[55]	[18]	-7	hSpCas9	negative selection	11898432
193659540	193659563	3	+	28162770	MV411	viability	GAAGAATCGGACCCAAGAACAGG	OPA1	ENSG00000198836	-2.281815517352093	[126]	[21]	-8	hSpCas9	negative selection	11898433
193643389	193643412	3	+	28162770	MV411	viability	TAAAAGGCCCTGGACTACAGAGG	OPA1	ENSG00000198836	-1.4561694464369999	[227]	[69]	-7	hSpCas9	negative selection	11898434
193648116	193648139	3	-	28162770	MV411	viability	TTACCCGGTCAAGTTCCCGCAGG	OPA1	ENSG00000198836	-1.9684998484163732	[222]	[47]	-8	hSpCas9	negative selection	11898435
193666292	193666315	3	+	28162770	MV411	viability	TCAGTTGGAATGCAATGATGTGG	OPA1	ENSG00000198836	-2.2187042894440747	[430]	[77]	-8	hSpCas9	negative selection	11898436
193593383	193593406	3	+	28162770	MV411	viability	GCGACTACGTCGGGCCGCTGTGG	OPA1	ENSG00000198836	0.48190280441979816	[16]	[19]	4	hSpCas9	negative selection	11898437
193615724	193615747	3	+	28162770	MV411	viability	GATTGTGCCTGACATTGTGTGGG	OPA1	ENSG00000198836	-0.4671602303549762	[191]	[116]	-3	hSpCas9	negative selection	11898438
193657202	193657225	3	+	28162770	MONOMAC1	viability	CAAGTGGAATGACTTTGCGGAGG	OPA1	ENSG00000198836	-3.296572520610468	[59]	[6]	-9	hSpCas9	negative selection	12067795
193638009	193638032	3	+	28162770	MONOMAC1	viability	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-1.8815350213316242	[44]	[13]	-8	hSpCas9	negative selection	12067796
193637259	193637282	3	+	28162770	MONOMAC1	viability	ATACGCAAGATCATCTGCCACGG	OPA1	ENSG00000198836	-1.2696054730101987	[264]	[125]	-7	hSpCas9	negative selection	12067797
193654952	193654975	3	+	28162770	MONOMAC1	viability	AGGAACTTTTAACACCACAGTGG	OPA1	ENSG00000198836	-1.4865434642545385	[43]	[17]	-8	hSpCas9	negative selection	12067798
193659540	193659563	3	+	28162770	MONOMAC1	viability	GAAGAATCGGACCCAAGAACAGG	OPA1	ENSG00000198836	-1.9022935814984216	[74]	[22]	-8	hSpCas9	negative selection	12067799
193643389	193643412	3	+	28162770	MONOMAC1	viability	TAAAAGGCCCTGGACTACAGAGG	OPA1	ENSG00000198836	-1.1299226512010168	[146]	[76]	-7	hSpCas9	negative selection	12067800
193648116	193648139	3	-	28162770	MONOMAC1	viability	TTACCCGGTCAAGTTCCCGCAGG	OPA1	ENSG00000198836	-1.149731132281197	[119]	[61]	-7	hSpCas9	negative selection	12067801
193666292	193666315	3	+	28162770	MONOMAC1	viability	TCAGTTGGAATGCAATGATGTGG	OPA1	ENSG00000198836	-1.7116100198893118	[279]	[97]	-8	hSpCas9	negative selection	12067802
193593383	193593406	3	+	28162770	MONOMAC1	viability	GCGACTACGTCGGGCCGCTGTGG	OPA1	ENSG00000198836	-0.9340024412257604	[4]	[2]	-6	hSpCas9	negative selection	12067803
193615724	193615747	3	+	28162770	MONOMAC1	viability	GATTGTGCCTGACATTGTGTGGG	OPA1	ENSG00000198836	-1.3030784844698782	[126]	[58]	-7	hSpCas9	negative selection	12067804
193657202	193657225	3	+	28162770	OCIAML2	viability	CAAGTGGAATGACTTTGCGGAGG	OPA1	ENSG00000198836	-1.4350059155114399	[19]	[40]	-7	hSpCas9	negative selection	12237161
193638009	193638032	3	+	28162770	OCIAML2	viability	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	-1.733664231075955	[8]	[14]	-8	hSpCas9	negative selection	12237162
193637259	193637282	3	+	28162770	OCIAML2	viability	ATACGCAAGATCATCTGCCACGG	OPA1	ENSG00000198836	-1.6570429494730425	[65]	[115]	-7	hSpCas9	negative selection	12237163
193654952	193654975	3	+	28162770	OCIAML2	viability	AGGAACTTTTAACACCACAGTGG	OPA1	ENSG00000198836	-0.470629825242161	[17]	[71]	-4	hSpCas9	negative selection	12237164
193659540	193659563	3	+	28162770	OCIAML2	viability	GAAGAATCGGACCCAAGAACAGG	OPA1	ENSG00000198836	-1.8331999046268694	[17]	[27]	-8	hSpCas9	negative selection	12237165
193643389	193643412	3	+	28162770	OCIAML2	viability	TAAAAGGCCCTGGACTACAGAGG	OPA1	ENSG00000198836	-1.5303360713664291	[36]	[70]	-7	hSpCas9	negative selection	12237166
193648116	193648139	3	-	28162770	OCIAML2	viability	TTACCCGGTCAAGTTCCCGCAGG	OPA1	ENSG00000198836	-2.326239915906986	[37]	[41]	-8	hSpCas9	negative selection	12237167
193666292	193666315	3	+	28162770	OCIAML2	viability	TCAGTTGGAATGCAATGATGTGG	OPA1	ENSG00000198836	-1.7466909113721947	[88]	[146]	-8	hSpCas9	negative selection	12237168
193593383	193593406	3	+	28162770	OCIAML2	viability	GCGACTACGTCGGGCCGCTGTGG	OPA1	ENSG00000198836	2.8147723936200872	[0]	[38]	9	hSpCas9	negative selection	12237169
193615724	193615747	3	+	28162770	OCIAML2	viability	GATTGTGCCTGACATTGTGTGGG	OPA1	ENSG00000198836	0.0006758936834277973	[43]	[243]	0	hSpCas9	negative selection	12237170
193657202	193657225	3	+	28162770	OCIAML3	viability	CAAGTGGAATGACTTTGCGGAGG	OPA1	ENSG00000198836	0.4059923596758367	[23]	[95]	4	hSpCas9	negative selection	12406527
193638009	193638032	3	+	28162770	OCIAML3	viability	CAAGCTCGAATATTCCCAAGAGG	OPA1	ENSG00000198836	0.8119847193516734	[9]	[52]	7	hSpCas9	negative selection	12406528
193637259	193637282	3	+	28162770	OCIAML3	viability	ATACGCAAGATCATCTGCCACGG	OPA1	ENSG00000198836	-0.5230411189700198	[118]	[249]	-4	hSpCas9	negative selection	12406529
193654952	193654975	3	+	28162770	OCIAML3	viability	AGGAACTTTTAACACCACAGTGG	OPA1	ENSG00000198836	-0.10215454399448842	[15]	[44]	-1	hSpCas9	negative selection	12406530
193659540	193659563	3	+	28162770	OCIAML3	viability	GAAGAATCGGACCCAAGAACAGG	OPA1	ENSG00000198836	0.8128093521497123	[32]	[174]	7	hSpCas9	negative selection	12406531
193643389	193643412	3	+	28162770	OCIAML3	viability	TAAAAGGCCCTGGACTACAGAGG	OPA1	ENSG00000198836	0.20485248756798546	[72]	[253]	2	hSpCas9	negative selection	12406532
193648116	193648139	3	-	28162770	OCIAML3	viability	TTACCCGGTCAAGTTCCCGCAGG	OPA1	ENSG00000198836	0.31718309271798084	[66]	[251]	3	hSpCas9	negative selection	12406533
193666292	193666315	3	+	28162770	OCIAML3	viability	TCAGTTGGAATGCAATGATGTGG	OPA1	ENSG00000198836	0.47591106448660114	[145]	[612]	4	hSpCas9	negative selection	12406534
193593383	193593406	3	+	28162770	OCIAML3	viability	GCGACTACGTCGGGCCGCTGTGG	OPA1	ENSG00000198836	-1.5940076403241634	[5]	[5]	-8	hSpCas9	negative selection	12406535
193615724	193615747	3	+	28162770	OCIAML3	viability	GATTGTGCCTGACATTGTGTGGG	OPA1	ENSG00000198836	0.3399031692180645	[66]	[255]	3	hSpCas9	negative selection	12406536