Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:4986
• Symbol:OPRK1
• Description:opioid receptor kappa 1

DataSource: http://genomecrispr.dkfz.de/#!/results/OPRK1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
53234758	53234781	8	-	26472758	Jiyoye	viability	GGAGGCACCAAAGTCAGGGAAGG	OPRK1	ENSG00000082556	-0.3082570511106914	[132]	[80]	-2	hSpCas9	negative selection	113926
53235015	53235038	8	+	26472758	Jiyoye	viability	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	0.5591784749509234	[161]	[179]	4	hSpCas9	negative selection	113927
53250852	53250875	8	+	26472758	Jiyoye	viability	GATGATGACCGGGATGGCCGGGG	OPRK1	ENSG00000082556	0.44465008692453634	[113]	[116]	3	hSpCas9	negative selection	113928
53250939	53250962	8	-	26472758	Jiyoye	viability	GCAGCGCCTGGTTTCCCGGCTGG	OPRK1	ENSG00000082556	0.48054856783609273	[114]	[120]	3	hSpCas9	negative selection	113929
53250865	53250888	8	+	26472758	Jiyoye	viability	ATGGCCGGGGAGATGTGCGCGGG	OPRK1	ENSG00000082556	0.5466747944939766	[196]	[216]	4	hSpCas9	negative selection	113930
53250910	53250933	8	-	26472758	Jiyoye	viability	CCCGACAGCAACGGCAGCGCCGG	OPRK1	ENSG00000082556	0.815640226861231	[164]	[218]	6	hSpCas9	negative selection	113931
53234864	53234887	8	+	26472758	Jiyoye	viability	AGTCCAAAGCCTTCACGGGGTGG	OPRK1	ENSG00000082556	0.7856870047596032	[39]	[51]	5	hSpCas9	negative selection	113932
53251009	53251032	8	-	26472758	Jiyoye	viability	TCCCCGATCCAGATCTTCCGCGG	OPRK1	ENSG00000082556	-0.10739779132388483	[359]	[251]	-1	hSpCas9	negative selection	113933
53250821	53250844	8	-	26472758	Jiyoye	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	-0.4293258862112471	[99]	[55]	-3	hSpCas9	negative selection	113934
53234882	53234905	8	+	26472758	Jiyoye	viability	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	0.2788512845303339	[281]	[257]	2	hSpCas9	negative selection	113935
53234758	53234781	8	-	26472758	KBM7	viability	GGAGGCACCAAAGTCAGGGAAGG	OPRK1	ENSG00000082556	-0.46444226573332104	[263,313]	[102,96]	-4	hSpCas9	negative selection	305044
53235015	53235038	8	+	26472758	KBM7	viability	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	-0.2313646632185895	[852,790]	[403,262]	-2	hSpCas9	negative selection	305045
53250852	53250875	8	+	26472758	KBM7	viability	GATGATGACCGGGATGGCCGGGG	OPRK1	ENSG00000082556	0.5498031121727812	[473,266]	[258,239]	6	hSpCas9	negative selection	305046
53250939	53250962	8	-	26472758	KBM7	viability	GCAGCGCCTGGTTTCCCGGCTGG	OPRK1	ENSG00000082556	0.7855548818899966	[818,428]	[462,517]	8	hSpCas9	negative selection	305047
53250865	53250888	8	+	26472758	KBM7	viability	ATGGCCGGGGAGATGTGCGCGGG	OPRK1	ENSG00000082556	0.1820242382752173	[898,499]	[447,288]	1	hSpCas9	negative selection	305048
53250910	53250933	8	-	26472758	KBM7	viability	CCCGACAGCAACGGCAGCGCCGG	OPRK1	ENSG00000082556	0.3271316267656258	[690,716]	[397,435]	3	hSpCas9	negative selection	305049
53234864	53234887	8	+	26472758	KBM7	viability	AGTCCAAAGCCTTCACGGGGTGG	OPRK1	ENSG00000082556	0.5770830095729711	[336,171]	[192,155]	6	hSpCas9	negative selection	305050
53251009	53251032	8	-	26472758	KBM7	viability	TCCCCGATCCAGATCTTCCGCGG	OPRK1	ENSG00000082556	0.09526627639088703	[907,894]	[271,617]	0	hSpCas9	negative selection	305051
53250821	53250844	8	-	26472758	KBM7	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	1.0984777705230169	[460,353]	[382,427]	9	hSpCas9	negative selection	305052
53234882	53234905	8	+	26472758	KBM7	viability	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	-0.10583729622393512	[1095,1111]	[360,595]	-1	hSpCas9	negative selection	305053
53234758	53234781	8	-	26472758	Raji	viability	GGAGGCACCAAAGTCAGGGAAGG	OPRK1	ENSG00000082556	-0.2911658411166753	[115]	[21]	-2	hSpCas9	negative selection	496162
53235015	53235038	8	+	26472758	Raji	viability	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	0.476408636895607	[445]	[143]	4	hSpCas9	negative selection	496163
53250852	53250875	8	+	26472758	Raji	viability	GATGATGACCGGGATGGCCGGGG	OPRK1	ENSG00000082556	1.0793691592040027	[207]	[101]	8	hSpCas9	negative selection	496164
53250939	53250962	8	-	26472758	Raji	viability	GCAGCGCCTGGTTTCCCGGCTGG	OPRK1	ENSG00000082556	1.2297190782976515	[225]	[122]	9	hSpCas9	negative selection	496165
53250865	53250888	8	+	26472758	Raji	viability	ATGGCCGGGGAGATGTGCGCGGG	OPRK1	ENSG00000082556	0.3609576119583271	[254]	[75]	3	hSpCas9	negative selection	496166
53250910	53250933	8	-	26472758	Raji	viability	CCCGACAGCAACGGCAGCGCCGG	OPRK1	ENSG00000082556	1.4679732506300671	[242]	[155]	9	hSpCas9	negative selection	496167
53234864	53234887	8	+	26472758	Raji	viability	AGTCCAAAGCCTTCACGGGGTGG	OPRK1	ENSG00000082556	-0.542870425599276	[112]	[17]	-4	hSpCas9	negative selection	496168
53251009	53251032	8	-	26472758	Raji	viability	TCCCCGATCCAGATCTTCCGCGG	OPRK1	ENSG00000082556	0.7133410196703072	[522]	[198]	6	hSpCas9	negative selection	496169
53250821	53250844	8	-	26472758	Raji	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.8195812243908634	[187]	[76]	7	hSpCas9	negative selection	496170
53234882	53234905	8	+	26472758	Raji	viability	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	0.5571864528131198	[450]	[153]	5	hSpCas9	negative selection	496171
53234758	53234781	8	-	26472758	K562	viability	GGAGGCACCAAAGTCAGGGAAGG	OPRK1	ENSG00000082556	-0.1690004932140144	[296]	[222]	-1	hSpCas9	negative selection	687280
53235015	53235038	8	+	26472758	K562	viability	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	0.7359977818182839	[701]	[986]	6	hSpCas9	negative selection	687281
53250852	53250875	8	+	26472758	K562	viability	GATGATGACCGGGATGGCCGGGG	OPRK1	ENSG00000082556	1.2932309770193906	[246]	[510]	9	hSpCas9	negative selection	687282
53250939	53250962	8	-	26472758	K562	viability	GCAGCGCCTGGTTTCCCGGCTGG	OPRK1	ENSG00000082556	-0.0847248617658829	[450]	[358]	0	hSpCas9	negative selection	687283
53250865	53250888	8	+	26472758	K562	viability	ATGGCCGGGGAGATGTGCGCGGG	OPRK1	ENSG00000082556	0.4194283857030165	[534]	[603]	3	hSpCas9	negative selection	687284
53250910	53250933	8	-	26472758	K562	viability	CCCGACAGCAACGGCAGCGCCGG	OPRK1	ENSG00000082556	0.6994880868511717	[541]	[742]	6	hSpCas9	negative selection	687285
53234864	53234887	8	+	26472758	K562	viability	AGTCCAAAGCCTTCACGGGGTGG	OPRK1	ENSG00000082556	0.9776321869715456	[230]	[383]	7	hSpCas9	negative selection	687286
53251009	53251032	8	-	26472758	K562	viability	TCCCCGATCCAGATCTTCCGCGG	OPRK1	ENSG00000082556	-0.4778092479565025	[908]	[550]	-3	hSpCas9	negative selection	687287
53250821	53250844	8	-	26472758	K562	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	-0.19713329012571162	[420]	[309]	-1	hSpCas9	negative selection	687288
53234882	53234905	8	+	26472758	K562	viability	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	0.4195054342245381	[774]	[874]	3	hSpCas9	negative selection	687289
53229614	53229637	8	-	26627737	DLD1	viability	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	0.21343093169235794	[944]	[248,353,413]	2	hSpCas9	negative selection	839727
53229644	53229667	8	+	26627737	DLD1	viability	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.7731339269984523	[666]	[433,464,198]	7	hSpCas9	negative selection	839728
53235015	53235038	8	+	26627737	DLD1	viability	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	-0.008795495789105434	[175]	[27,109,31]	0	hSpCas9	negative selection	839729
53242838	53242861	8	-	26627737	DLD1	viability	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	-0.8706874979282935	[370]	[90,86,19]	-7	hSpCas9	negative selection	839730
53250846	53250869	8	+	26627737	DLD1	viability	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	-0.03975608799782049	[1321]	[307,433,456]	0	hSpCas9	negative selection	839731
53250919	53250942	8	-	26627737	DLD1	viability	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	0.6537472299325511	[627]	[274,302,342]	6	hSpCas9	negative selection	839732
53229614	53229637	8	-	26627737	GBM cells	viability after 5 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	0.593010207279346	[525]	[456,393]	8	hSpCas9	negative selection	922042
53229644	53229667	8	+	26627737	GBM cells	viability after 5 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.2102837780744713	[767]	[439,512]	3	hSpCas9	negative selection	922043
53235015	53235038	8	+	26627737	GBM cells	viability after 5 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	1.0099451872744294	[74]	[63,97]	9	hSpCas9	negative selection	922044
53242838	53242861	8	-	26627737	GBM cells	viability after 5 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	0.047510366887486166	[211]	[157,76]	0	hSpCas9	negative selection	922045
53250846	53250869	8	+	26627737	GBM cells	viability after 5 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	0.2216112020178187	[374]	[235,232]	3	hSpCas9	negative selection	922046
53250919	53250942	8	-	26627737	GBM cells	viability after 5 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	0.14799489845779634	[328]	[237,152]	2	hSpCas9	negative selection	922047
53229614	53229637	8	-	26627737	GBM cells	viability after 13 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	0.710962524377823	[525]	[518,424]	8	hSpCas9	negative selection	1004357
53229644	53229667	8	+	26627737	GBM cells	viability after 13 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.4514747747001773	[767]	[678,480]	6	hSpCas9	negative selection	1004358
53235015	53235038	8	+	26627737	GBM cells	viability after 13 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	1.1363888807042315	[74]	[105,75]	9	hSpCas9	negative selection	1004359
53242838	53242861	8	-	26627737	GBM cells	viability after 13 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	-0.06022062457362137	[211]	[138,86]	0	hSpCas9	negative selection	1004360
53250846	53250869	8	+	26627737	GBM cells	viability after 13 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	-0.023939077391750274	[374]	[230,174]	0	hSpCas9	negative selection	1004361
53250919	53250942	8	-	26627737	GBM cells	viability after 13 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	0.2606345887378556	[328]	[268,168]	3	hSpCas9	negative selection	1004362
53229614	53229637	8	-	26627737	GBM cells	viability after 21 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	0.9664981482814232	[525]	[536,577]	8	hSpCas9	negative selection	1086672
53229644	53229667	8	+	26627737	GBM cells	viability after 21 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.7239333916902246	[767]	[767,616]	7	hSpCas9	negative selection	1086673
53235015	53235038	8	+	26627737	GBM cells	viability after 21 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	2.2686575764972847	[74]	[199,192]	9	hSpCas9	negative selection	1086674
53242838	53242861	8	-	26627737	GBM cells	viability after 21 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	0.24483509586419122	[211]	[136,135]	2	hSpCas9	negative selection	1086675
53250846	53250869	8	+	26627737	GBM cells	viability after 21 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	-0.2846990080293782	[374]	[184,150]	-3	hSpCas9	negative selection	1086676
53250919	53250942	8	-	26627737	GBM cells	viability after 21 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	0.2559312248973423	[328]	[214,211]	2	hSpCas9	negative selection	1086677
53229614	53229637	8	-	26627737	RPE1	viability after 9 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	0.1285976218924234	[3010]	[985,1087]	0	hSpCas9	negative selection	1168987
53229644	53229667	8	+	26627737	RPE1	viability after 9 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.7140677563049305	[2253]	[854,1547]	5	hSpCas9	negative selection	1168988
53235015	53235038	8	+	26627737	RPE1	viability after 9 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	0.6395043259205493	[248]	[89,161]	4	hSpCas9	negative selection	1168989
53242838	53242861	8	-	26627737	RPE1	viability after 9 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	0.3696292518436483	[892]	[248,505]	2	hSpCas9	negative selection	1168990
53250846	53250869	8	+	26627737	RPE1	viability after 9 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	-0.08084451172775364	[1748]	[470,577]	0	hSpCas9	negative selection	1168991
53250919	53250942	8	-	26627737	RPE1	viability after 9 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	0.7936730996912742	[1056]	[391,807]	5	hSpCas9	negative selection	1168992
53229614	53229637	8	-	26627737	RPE1	viability after 12 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	0.21611892481371786	[3010]	[775,1112]	1	hSpCas9	negative selection	1251302
53229644	53229667	8	+	26627737	RPE1	viability after 12 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.8498038449861973	[2253]	[934,1256]	5	hSpCas9	negative selection	1251303
53235015	53235038	8	+	26627737	RPE1	viability after 12 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	0.9654361508745686	[248]	[100,161]	6	hSpCas9	negative selection	1251304
53242838	53242861	8	-	26627737	RPE1	viability after 12 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	-0.13651989425872896	[892]	[124,316]	-1	hSpCas9	negative selection	1251305
53250846	53250869	8	+	26627737	RPE1	viability after 12 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	-0.012017017594234458	[1748]	[448,483]	0	hSpCas9	negative selection	1251306
53250919	53250942	8	-	26627737	RPE1	viability after 12 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	0.6482911360701322	[1056]	[379,513]	4	hSpCas9	negative selection	1251307
53229614	53229637	8	-	26627737	RPE1	viability after 15 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	0.5711053415185954	[3010]	[1101,1422]	3	hSpCas9	negative selection	1333617
53229644	53229667	8	+	26627737	RPE1	viability after 15 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.9601883560023852	[2253]	[1183,1294]	6	hSpCas9	negative selection	1333618
53235015	53235038	8	+	26627737	RPE1	viability after 15 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	1.635773687795353	[248]	[140,293]	8	hSpCas9	negative selection	1333619
53242838	53242861	8	-	26627737	RPE1	viability after 15 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	-0.3088862545231618	[892]	[151,253]	-2	hSpCas9	negative selection	1333620
53250846	53250869	8	+	26627737	RPE1	viability after 15 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	-0.2884410940540425	[1748]	[258,545]	-2	hSpCas9	negative selection	1333621
53250919	53250942	8	-	26627737	RPE1	viability after 15 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	0.8015296730336132	[1056]	[512,528]	5	hSpCas9	negative selection	1333622
53229614	53229637	8	-	26627737	RPE1	viability after 18 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	0.6303563597306141	[3010]	[1106,1418]	4	hSpCas9	negative selection	1415932
53229644	53229667	8	+	26627737	RPE1	viability after 18 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.8507131058326023	[2253]	[833,1377]	5	hSpCas9	negative selection	1415933
53235015	53235038	8	+	26627737	RPE1	viability after 18 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	1.1314302429075598	[248]	[65,233]	6	hSpCas9	negative selection	1415934
53242838	53242861	8	-	26627737	RPE1	viability after 18 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	-0.028380966557558035	[892]	[244,226]	0	hSpCas9	negative selection	1415935
53250846	53250869	8	+	26627737	RPE1	viability after 18 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	-0.1397263094423915	[1748]	[338,523]	-1	hSpCas9	negative selection	1415936
53250919	53250942	8	-	26627737	RPE1	viability after 18 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	0.7698742796236115	[1056]	[351,629]	5	hSpCas9	negative selection	1415937
53229614	53229637	8	-	26627737	HeLa	viability after 8 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	-0.05160258147468433	[1405]	[681,724,397]	0	hSpCas9	negative selection	1498247
53229644	53229667	8	+	26627737	HeLa	viability after 8 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.21049384931987958	[932]	[574,336,516]	2	hSpCas9	negative selection	1498248
53235015	53235038	8	+	26627737	HeLa	viability after 8 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	1.419156925457256	[70]	[50,4,177]	8	hSpCas9	negative selection	1498249
53242838	53242861	8	-	26627737	HeLa	viability after 8 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	0.004594199838718727	[328]	[279,142,44]	0	hSpCas9	negative selection	1498250
53250846	53250869	8	+	26627737	HeLa	viability after 8 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	0.32452583026419934	[899]	[350,605,483]	3	hSpCas9	negative selection	1498251
53250919	53250942	8	-	26627737	HeLa	viability after 8 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	-0.5135683299479179	[950]	[233,313,307]	-5	hSpCas9	negative selection	1498252
53229614	53229637	8	-	26627737	HeLa	viability after 12 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	-0.20815238081783405	[1405]	[582,297,651]	-2	hSpCas9	negative selection	1580562
53229644	53229667	8	+	26627737	HeLa	viability after 12 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.15701232058810288	[932]	[440,335,522]	1	hSpCas9	negative selection	1580563
53235015	53235038	8	+	26627737	HeLa	viability after 12 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	1.525801245588269	[70]	[98,73,81]	8	hSpCas9	negative selection	1580564
53242838	53242861	8	-	26627737	HeLa	viability after 12 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	0.8873037832549546	[328]	[180,349,210]	7	hSpCas9	negative selection	1580565
53250846	53250869	8	+	26627737	HeLa	viability after 12 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	-0.1142027471224758	[899]	[438,264,337]	-1	hSpCas9	negative selection	1580566
53250919	53250942	8	-	26627737	HeLa	viability after 12 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	-0.47464029956575104	[950]	[233,292,318]	-4	hSpCas9	negative selection	1580567
53229614	53229637	8	-	26627737	HeLa	viability after 15 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	-0.17053967028218553	[1405]	[644,236,652]	-1	hSpCas9	negative selection	1662877
53229644	53229667	8	+	26627737	HeLa	viability after 15 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.4300427159125191	[932]	[464,459,618]	3	hSpCas9	negative selection	1662878
53235015	53235038	8	+	26627737	HeLa	viability after 15 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	1.792623769277208	[70]	[66,167,62]	9	hSpCas9	negative selection	1662879
53242838	53242861	8	-	26627737	HeLa	viability after 15 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	0.42886741742595763	[328]	[154,244,137]	3	hSpCas9	negative selection	1662880
53250846	53250869	8	+	26627737	HeLa	viability after 15 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	0.05198326102455386	[899]	[389,361,387]	0	hSpCas9	negative selection	1662881
53250919	53250942	8	-	26627737	HeLa	viability after 15 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	-0.8754545133663977	[950]	[198,189,246]	-6	hSpCas9	negative selection	1662882
53229614	53229637	8	-	26627737	HeLa	viability after 18 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	-0.18632925681310653	[1405]	[422,194,652]	-1	hSpCas9	negative selection	1745192
53229644	53229667	8	+	26627737	HeLa	viability after 18 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.4316167756103446	[932]	[304,390,618]	3	hSpCas9	negative selection	1745193
53235015	53235038	8	+	26627737	HeLa	viability after 18 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	1.828890444639267	[70]	[49,138,62]	9	hSpCas9	negative selection	1745194
53242838	53242861	8	-	26627737	HeLa	viability after 18 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	0.4135955025346143	[328]	[104,196,137]	3	hSpCas9	negative selection	1745195
53250846	53250869	8	+	26627737	HeLa	viability after 18 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	0.06118289192543158	[899]	[262,303,387]	0	hSpCas9	negative selection	1745196
53250919	53250942	8	-	26627737	HeLa	viability after 18 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	-0.8866830904515476	[950]	[128,158,246]	-7	hSpCas9	negative selection	1745197
53229614	53229637	8	-	26627737	HCT116	viability after 6 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	-0.3185986278030343	[1521]	[381,86]	-2	hSpCas9	negative selection	1827507
53229644	53229667	8	+	26627737	HCT116	viability after 6 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	-0.9296777845382628	[1113]	[196,33]	-5	hSpCas9	negative selection	1827508
53235015	53235038	8	+	26627737	HCT116	viability after 6 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	-0.7777153470240186	[134]	[3,16]	-4	hSpCas9	negative selection	1827509
53242838	53242861	8	-	26627737	HCT116	viability after 6 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	-0.47071849709285624	[516]	[28,74]	-3	hSpCas9	negative selection	1827510
53250846	53250869	8	+	26627737	HCT116	viability after 6 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	0.8568531030111919	[746]	[115,265]	5	hSpCas9	negative selection	1827511
53250919	53250942	8	-	26627737	HCT116	viability after 6 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	0.5745126988443487	[800]	[260,146]	3	hSpCas9	negative selection	1827512
53229614	53229637	8	-	26627737	HCT116	viability after 8 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	0.7033463731173375	[555]	[429,455,607]	6	hSpCas9	negative selection	1909822
53229644	53229667	8	+	26627737	HCT116	viability after 8 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.6223962630332895	[551]	[653,446,308]	6	hSpCas9	negative selection	1909823
53235015	53235038	8	+	26627737	HCT116	viability after 8 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	0.18306142673516979	[54]	[27,31,42]	2	hSpCas9	negative selection	1909824
53242838	53242861	8	-	26627737	HCT116	viability after 8 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	0.9647464296429008	[118]	[166,119,97]	8	hSpCas9	negative selection	1909825
53250846	53250869	8	+	26627737	HCT116	viability after 8 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	0.2409032047316847	[509]	[287,416,290]	2	hSpCas9	negative selection	1909826
53250919	53250942	8	-	26627737	HCT116	viability after 8 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	0.5101317548703355	[439]	[275,359,397]	5	hSpCas9	negative selection	1909827
53229614	53229637	8	-	26627737	HCT116	viability after 9 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	0.2873810690081706	[1521]	[829,231]	2	hSpCas9	negative selection	1992137
53229644	53229667	8	+	26627737	HCT116	viability after 9 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.20472509048832654	[1113]	[377,314]	1	hSpCas9	negative selection	1992138
53235015	53235038	8	+	26627737	HCT116	viability after 9 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	2.4759243201818535	[134]	[99,279]	9	hSpCas9	negative selection	1992139
53242838	53242861	8	-	26627737	HCT116	viability after 9 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	-1.029617950424596	[516]	[13,109]	-6	hSpCas9	negative selection	1992140
53250846	53250869	8	+	26627737	HCT116	viability after 9 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	0.4558737892352349	[746]	[205,326]	3	hSpCas9	negative selection	1992141
53250919	53250942	8	-	26627737	HCT116	viability after 9 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	0.47189896519840757	[800]	[280,308]	3	hSpCas9	negative selection	1992142
53229614	53229637	8	-	26627737	HCT116	viability after 12 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	0.639060973978437	[555]	[497,399,461]	6	hSpCas9	negative selection	2074452
53229644	53229667	8	+	26627737	HCT116	viability after 12 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.5142612277524625	[551]	[412,492,338]	5	hSpCas9	negative selection	2074453
53235015	53235038	8	+	26627737	HCT116	viability after 12 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	0.5634621307424059	[54]	[9,41,78]	5	hSpCas9	negative selection	2074454
53242838	53242861	8	-	26627737	HCT116	viability after 12 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	1.630758738958352	[118]	[250,112,209]	9	hSpCas9	negative selection	2074455
53250846	53250869	8	+	26627737	HCT116	viability after 12 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	0.4883696349797485	[509]	[385,371,368]	5	hSpCas9	negative selection	2074456
53250919	53250942	8	-	26627737	HCT116	viability after 12 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	0.5425690891199946	[439]	[378,348,278]	5	hSpCas9	negative selection	2074457
53229614	53229637	8	-	26627737	HCT116	viability after 15 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	0.7754659825749095	[555]	[441,638,545]	6	hSpCas9	negative selection	2156767
53229644	53229667	8	+	26627737	HCT116	viability after 15 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.4493519822218519	[551]	[555,361,395]	4	hSpCas9	negative selection	2156768
53235015	53235038	8	+	26627737	HCT116	viability after 15 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	1.0053740567591622	[54]	[50,97,39]	8	hSpCas9	negative selection	2156769
53242838	53242861	8	-	26627737	HCT116	viability after 15 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	1.3621285221047965	[118]	[234,184,114]	8	hSpCas9	negative selection	2156770
53250846	53250869	8	+	26627737	HCT116	viability after 15 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	0.749333916745769	[509]	[433,712,324]	6	hSpCas9	negative selection	2156771
53250919	53250942	8	-	26627737	HCT116	viability after 15 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	0.4348977046643736	[439]	[329,321,370]	4	hSpCas9	negative selection	2156772
53229614	53229637	8	-	26627737	HCT116	viability after 18 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	0.740759095600332	[555]	[335,465,548]	6	hSpCas9	negative selection	2239082
53229644	53229667	8	+	26627737	HCT116	viability after 18 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.2414689592333601	[551]	[271,362,307]	2	hSpCas9	negative selection	2239083
53235015	53235038	8	+	26627737	HCT116	viability after 18 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	0.798685855968539	[54]	[15,107,8]	6	hSpCas9	negative selection	2239084
53242838	53242861	8	-	26627737	HCT116	viability after 18 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	1.4346271005014377	[118]	[285,97,82]	8	hSpCas9	negative selection	2239085
53250846	53250869	8	+	26627737	HCT116	viability after 18 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	0.8030039421879968	[509]	[387,494,401]	6	hSpCas9	negative selection	2239086
53250919	53250942	8	-	26627737	HCT116	viability after 18 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	0.7180642778964812	[439]	[346,348,353]	6	hSpCas9	negative selection	2239087
53234752	53234775	8	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCTCTTACCTTCCCTGACTTTGG	OPRK1	ENSG00000082556	0.07954392037284347	[4,4]	[4,4]	1	hSpCas9	positive selection	3007452
53234862	53234885	8	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGAAGTCCAAAGCCTTCACGGGG	OPRK1	ENSG00000082556	-0.23875367494803196	[2,2]	[1,1]	-3	hSpCas9	positive selection	3007453
53234883	53234906	8	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	0.38902425133945684	[2,2]	[2,3]	7	hSpCas9	positive selection	3007454
53234975	53234998	8	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TTGCACAGCACATCCCCAAAAGG	OPRK1	ENSG00000082556	0.09266140831296976	[5,5]	[5,4]	2	hSpCas9	positive selection	3007455
53234752	53234775	8	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCTCTTACCTTCCCTGACTTTGG	OPRK1	ENSG00000082556	0.12347233334479696	[4,4]	[4,2]	2	hSpCas9	positive selection	3075310
53234862	53234885	8	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGAAGTCCAAAGCCTTCACGGGG	OPRK1	ENSG00000082556	-0.6629482122052202	[2,2]	[1,0]	-8	hSpCas9	positive selection	3075311
53234883	53234906	8	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	0.6337157812837834	[2,2]	[2,3]	9	hSpCas9	positive selection	3075312
53234975	53234998	8	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TTGCACAGCACATCCCCAAAAGG	OPRK1	ENSG00000082556	0.0968828996624923	[5,5]	[5,3]	1	hSpCas9	positive selection	3075313
53235009	53235032		+	24336571	A375	resistance to PLX after 7 days	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.09178757149819106	[4,5]	[5,3]	-3	hSpCas9	positive selection	3132502
53250821	53250844		-	24336571	A375	resistance to PLX after 7 days	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	-0.08755934790594155	[14,14]	[13,14]	-3	hSpCas9	positive selection	3132503
53234873	53234896		-	24336571	A375	resistance to PLX after 7 days	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	0.06336237822180169	[15,16]	[15,18]	2	hSpCas9	positive selection	3132504
53235009	53235032		+	24336571	A375	resistance to PLX after 14 days	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	0.5271371775133791	[4,4]	[2,3]	5	hSpCas9	positive selection	3190295
53250821	53250844		-	24336571	A375	resistance to PLX after 14 days	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	-0.38161539414745427	[11,15]	[4,4]	-4	hSpCas9	positive selection	3190296
53234873	53234896		-	24336571	A375	resistance to PLX after 14 days	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	0.262975694488299	[16,16]	[9,8]	2	hSpCas9	positive selection	3190297
53235009	53235032		+	24336571	A375	viability after 7 days	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.29731681116457775	[6]	[4,5]	-4	hSpCas9	negative selection	3248088
53250821	53250844		-	24336571	A375	viability after 7 days	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.2836914887169925	[12]	[14,14]	4	hSpCas9	negative selection	3248089
53234873	53234896		-	24336571	A375	viability after 7 days	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	0.6027160705245301	[10]	[15,16]	8	hSpCas9	negative selection	3248090
53235009	53235032		+	24336571	A375	viability after 14 days	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.2708347814808668	[6]	[4,4]	-3	hSpCas9	negative selection	3305881
53250821	53250844		-	24336571	A375	viability after 14 days	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.19028044239196606	[12]	[11,15]	2	hSpCas9	negative selection	3305882
53234873	53234896		-	24336571	A375	viability after 14 days	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	0.6747571460446797	[10]	[16,16]	8	hSpCas9	negative selection	3305883
53250816	53250839	8	+	27383988	293T	resistance to West Nile virus (flavivirus)	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.2184072195205627	[177,177]	[0,0]	-1	hSpCas9	positive selection	3383062
53235009	53235032	8	+	27383988	293T	resistance to West Nile virus (flavivirus)	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	0.3148117061065953	[122,122]	[0,0]	1	hSpCas9	positive selection	3383063
53234873	53234896	8	-	27383988	293T	resistance to West Nile virus (flavivirus)	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.5174608481553384	[218,218]	[0,0]	-3	hSpCas9	positive selection	3383064
53234751	53234774	8	+	26780180	HT29	viability (Avana library 4 designs)	GCTCTTACCTTCCCTGACTTTGG	OPRK1	ENSG00000082556	0.382400191402482	[]	[]	1	hSpCas9	negative selection	3445386
53234861	53234884	8	+	26780180	HT29	viability (Avana library 4 designs)	GGAAGTCCAAAGCCTTCACGGGG	OPRK1	ENSG00000082556	0.763638953226245	[]	[]	3	hSpCas9	negative selection	3445387
53234882	53234905	8	+	26780180	HT29	viability (Avana library 4 designs)	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	1.77157493165997	[]	[]	6	hSpCas9	negative selection	3445388
53234974	53234997	8	+	26780180	HT29	viability (Avana library 4 designs)	TTGCACAGCACATCCCCAAAAGG	OPRK1	ENSG00000082556	-0.333259810232603	[]	[]	-5	hSpCas9	negative selection	3445389
53234861	53234884	8	+	26780180	A375	viability (Avana lentiCRISPRv2)	GGAAGTCCAAAGCCTTCACGGGG	OPRK1	ENSG00000082556	1.4464546826945	[]	[]	2	hSpCas9	negative selection	3538091
53234882	53234905	8	+	26780180	A375	viability (Avana lentiCRISPRv2)	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	1.04994504737018	[]	[]	1	hSpCas9	negative selection	3538092
53234751	53234774	8	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCTCTTACCTTCCCTGACTTTGG	OPRK1	ENSG00000082556	5.02762433128994	[]	[]	8	hSpCas9	negative selection	3538093
53234974	53234997	8	+	26780180	A375	viability (Avana lentiCRISPRv2)	TTGCACAGCACATCCCCAAAAGG	OPRK1	ENSG00000082556	2.05568007366086	[]	[]	3	hSpCas9	negative selection	3538094
53235010	53235033	8	+	26780180	A375	viability (Avana lentiCRISPRv2)	AAGTAGACCGTACTCTGAAAGGG	OPRK1	ENSG00000082556	-2.81903000001869	[]	[]	-3	hSpCas9	negative selection	3538095
53229773	53229796	8	-	26780180	A375	viability (Avana lentiCRISPRv2)	AGATGATGACTACTCCTGGTGGG	OPRK1	ENSG00000082556	3.70219735825798	[]	[]	6	hSpCas9	negative selection	3538096
53234861	53234884	8	+	26780180	A375	viability (Avana lentiGuide)	GGAAGTCCAAAGCCTTCACGGGG	OPRK1	ENSG00000082556	4.74979891775842	[]	[]	4	hSpCas9	negative selection	3646750
53234882	53234905	8	+	26780180	A375	viability (Avana lentiGuide)	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	0.288364466845565	[]	[]	0	hSpCas9	negative selection	3646751
53234751	53234774	8	+	26780180	A375	viability (Avana lentiGuide)	GCTCTTACCTTCCCTGACTTTGG	OPRK1	ENSG00000082556	-4.05557695487257	[]	[]	-7	hSpCas9	negative selection	3646752
53234974	53234997	8	+	26780180	A375	viability (Avana lentiGuide)	TTGCACAGCACATCCCCAAAAGG	OPRK1	ENSG00000082556	-3.87219699357432	[]	[]	-6	hSpCas9	negative selection	3646753
53235010	53235033	8	+	26780180	A375	viability (Avana lentiGuide)	AAGTAGACCGTACTCTGAAAGGG	OPRK1	ENSG00000082556	-1.36740163433464	[]	[]	-2	hSpCas9	negative selection	3646754
53229773	53229796	8	-	26780180	A375	viability (Avana lentiGuide)	AGATGATGACTACTCCTGGTGGG	OPRK1	ENSG00000082556	0.96331825609434	[]	[]	1	hSpCas9	negative selection	3646755
53234861	53234884	8	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGAAGTCCAAAGCCTTCACGGGG	OPRK1	ENSG00000082556	-0.14474615755270137	[3]	[3,3]	-2	hSpCas9	positive selection	3755409
53234882	53234905	8	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	0.13812972127207493	[4]	[5,5]	3	hSpCas9	positive selection	3755410
53234751	53234774	8	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCTCTTACCTTCCCTGACTTTGG	OPRK1	ENSG00000082556	0.14288080871279657	[5]	[6,4]	4	hSpCas9	positive selection	3755411
53234974	53234997	8	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTGCACAGCACATCCCCAAAAGG	OPRK1	ENSG00000082556	0.15583523631586527	[6]	[6,7]	4	hSpCas9	positive selection	3755412
53235010	53235033	8	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AAGTAGACCGTACTCTGAAAGGG	OPRK1	ENSG00000082556	-0.4317230835194511	[5]	[4,2]	-6	hSpCas9	positive selection	3755413
53229773	53229796	8	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AGATGATGACTACTCCTGGTGGG	OPRK1	ENSG00000082556	0.13289936650866133	[4]	[5,4]	3	hSpCas9	positive selection	3755414
53234861	53234884	8	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGAAGTCCAAAGCCTTCACGGGG	OPRK1	ENSG00000082556	-0.44012318333605915	[4]	[1,3]	-5	hSpCas9	positive selection	3864016
53234882	53234905	8	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	-0.633571604600199	[5]	[1,2]	-7	hSpCas9	positive selection	3864017
53234751	53234774	8	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCTCTTACCTTCCCTGACTTTGG	OPRK1	ENSG00000082556	0.3588714162177586	[6]	[6,6]	9	hSpCas9	positive selection	3864018
53234974	53234997	8	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTGCACAGCACATCCCCAAAAGG	OPRK1	ENSG00000082556	0.3196945337536813	[7]	[7,7]	8	hSpCas9	positive selection	3864019
53235010	53235033	8	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AAGTAGACCGTACTCTGAAAGGG	OPRK1	ENSG00000082556	0.06191273103437851	[4]	[3,4]	1	hSpCas9	positive selection	3864020
53229773	53229796	8	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AGATGATGACTACTCCTGGTGGG	OPRK1	ENSG00000082556	0.09372969256586676	[5]	[5,3]	2	hSpCas9	positive selection	3864021
53250816	53250839	8	+	26780180	A375	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	2.08231052099705	[]	[]	9	hSpCas9	negative selection	3975156
53235009	53235032	8	+	26780180	A375	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	0.990988979568883	[]	[]	4	hSpCas9	negative selection	3975157
53250821	53250844	8	-	26780180	A375	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.915018779899631	[]	[]	4	hSpCas9	negative selection	3975158
53229668	53229691	8	+	26780180	A375	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	1.44942003132449	[]	[]	8	hSpCas9	negative selection	3975159
53229669	53229692	8	-	26780180	A375	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	0.901306148839585	[]	[]	4	hSpCas9	negative selection	3975160
53234873	53234896	8	-	26780180	A375	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	1.48715845055736	[]	[]	8	hSpCas9	negative selection	3975161
53250816	53250839	8	+	26780180	HT29	viability (GeCKOv2 library)	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	1.58333242339643	[]	[]	8	hSpCas9	negative selection	4083122
53235009	53235032	8	+	26780180	HT29	viability (GeCKOv2 library)	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	1.36164749762897	[]	[]	7	hSpCas9	negative selection	4083123
53250821	53250844	8	-	26780180	HT29	viability (GeCKOv2 library)	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.312853240049027	[]	[]	0	hSpCas9	negative selection	4083124
53229668	53229691	8	+	26780180	HT29	viability (GeCKOv2 library)	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	1.36152185728184	[]	[]	7	hSpCas9	negative selection	4083125
53229669	53229692	8	-	26780180	HT29	viability (GeCKOv2 library)	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	1.12392659910511	[]	[]	5	hSpCas9	negative selection	4083126
53234873	53234896	8	-	26780180	HT29	viability (GeCKOv2 library)	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	1.51844205539974	[]	[]	7	hSpCas9	negative selection	4083127
53235009	53235032	8	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	0.25762197025790057	[1]	[1,1]	6	hSpCas9	positive selection	4157295
53250821	53250844	8	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	-0.03035501445656672	[3]	[2,2]	0	hSpCas9	positive selection	4157296
53234873	53234896	8	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.031333594441128806	[4]	[1,3]	0	hSpCas9	positive selection	4157297
53235009	53235032	8	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	1.343939564471075	[2]	[3,0,1,3]	9	hSpCas9	positive selection	4221317
53250821	53250844	8	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.5114628689206306	[2]	[1,2,4,0]	3	hSpCas9	positive selection	4221318
53234873	53234896	8	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	0.061405269872829155	[3]	[1,2,1,0]	0	hSpCas9	positive selection	4221319
53250821	53250844	8	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.386683499861619	[3]	[3,4]	7	hSpCas9	positive selection	4287099
53229668	53229691	8	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	-0.035756570593477914	[3]	[3,1]	0	hSpCas9	positive selection	4287100
53229669	53229692	8	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	-0.32138590560803004	[2]	[2,0]	-6	hSpCas9	positive selection	4287101
53250816	53250839	8	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	0.13197136036528942	[3]	[2,2]	2	hSpCas9	positive selection	4351354
53235009	53235032	8	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	0.0304808233972293	[2]	[3,1]	0	hSpCas9	positive selection	4351355
53234873	53234896	8	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.004089877870228159	[3]	[3,2]	0	hSpCas9	positive selection	4351356
53229669	53229691	8	+	27760321	OCIAML3	viability	CCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	-0.17880654813629482	[1005,821]	[689,547]	-2	hSpCas9	negative selection	4424675
53229750	53229772	8	+	27760321	OCIAML3	viability	GACGCAGATCTTCATGAAGAGG	OPRK1	ENSG00000082556	1.0785074763899294	[345,275]	[507,513]	9	hSpCas9	negative selection	4424676
53229777	53229799	8	-	27760321	OCIAML3	viability	CCCAGATGATGACTACTCCTGG	OPRK1	ENSG00000082556	0.5196707140742111	[513,387]	[425,599]	6	hSpCas9	negative selection	4424677
53229812	53229834	8	+	27760321	OCIAML3	viability	ACTCAATGACATCGACGTCTGG	OPRK1	ENSG00000082556	0.6052603580811322	[264,252]	[229,410]	7	hSpCas9	negative selection	4424678
53234862	53234884	8	+	27760321	OCIAML3	viability	GAAGTCCAAAGCCTTCACGGGG	OPRK1	ENSG00000082556	-0.32670760059780246	[567,406]	[253,361]	-3	hSpCas9	negative selection	4424679
53229669	53229691	8	+	27760321	OCIAML2	viability	CCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.5255820779287068	[1005,821]	[882,1290]	7	hSpCas9	negative selection	4508138
53229750	53229772	8	+	27760321	OCIAML2	viability	GACGCAGATCTTCATGAAGAGG	OPRK1	ENSG00000082556	-0.48011229562403135	[345,275]	[177,180]	-5	hSpCas9	negative selection	4508139
53229777	53229799	8	-	27760321	OCIAML2	viability	CCCAGATGATGACTACTCCTGG	OPRK1	ENSG00000082556	0.6902314270391665	[513,387]	[456,750]	8	hSpCas9	negative selection	4508140
53229812	53229834	8	+	27760321	OCIAML2	viability	ACTCAATGACATCGACGTCTGG	OPRK1	ENSG00000082556	0.6353774760618808	[264,252]	[255,417]	8	hSpCas9	negative selection	4508141
53234862	53234884	8	+	27760321	OCIAML2	viability	GAAGTCCAAAGCCTTCACGGGG	OPRK1	ENSG00000082556	0.26948419957636555	[567,406]	[441,507]	3	hSpCas9	negative selection	4508142
53229669	53229691	8	+	27760321	MV411	viability	CCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.8608313630338398	[1005,821]	[989,1239]	6	hSpCas9	negative selection	4591601
53229750	53229772	8	+	27760321	MV411	viability	GACGCAGATCTTCATGAAGAGG	OPRK1	ENSG00000082556	0.3681243304714905	[345,275]	[150,431]	2	hSpCas9	negative selection	4591602
53229777	53229799	8	-	27760321	MV411	viability	CCCAGATGATGACTACTCCTGG	OPRK1	ENSG00000082556	-0.8839270983543748	[513,387]	[105,240]	-5	hSpCas9	negative selection	4591603
53229812	53229834	8	+	27760321	MV411	viability	ACTCAATGACATCGACGTCTGG	OPRK1	ENSG00000082556	0.2044585506109755	[264,252]	[207,180]	1	hSpCas9	negative selection	4591604
53234862	53234884	8	+	27760321	MV411	viability	GAAGTCCAAAGCCTTCACGGGG	OPRK1	ENSG00000082556	1.1336037463481452	[567,406]	[437,1089]	8	hSpCas9	negative selection	4591605
53229669	53229691	8	+	27760321	HL60	viability	CCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.3936958723537358	[1005,821]	[859,1098]	5	hSpCas9	negative selection	4675064
53229750	53229772	8	+	27760321	HL60	viability	GACGCAGATCTTCATGAAGAGG	OPRK1	ENSG00000082556	-0.07481502729988587	[345,275]	[281,194]	-1	hSpCas9	negative selection	4675065
53229777	53229799	8	-	27760321	HL60	viability	CCCAGATGATGACTACTCCTGG	OPRK1	ENSG00000082556	0.07003663611096567	[513,387]	[385,380]	0	hSpCas9	negative selection	4675066
53229812	53229834	8	+	27760321	HL60	viability	ACTCAATGACATCGACGTCTGG	OPRK1	ENSG00000082556	0.3228329037861791	[264,252]	[297,229]	4	hSpCas9	negative selection	4675067
53234862	53234884	8	+	27760321	HL60	viability	GAAGTCCAAAGCCTTCACGGGG	OPRK1	ENSG00000082556	0.4237235711970884	[567,406]	[418,644]	5	hSpCas9	negative selection	4675068
53229669	53229691	8	+	27760321	HT1080	viability	CCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.4800735160881413	[821,641]	[369,446]	2	hSpCas9	negative selection	4758527
53229750	53229772	8	+	27760321	HT1080	viability	GACGCAGATCTTCATGAAGAGG	OPRK1	ENSG00000082556	0.6535077334624751	[275,215]	[178,126]	3	hSpCas9	negative selection	4758528
53229777	53229799	8	-	27760321	HT1080	viability	CCCAGATGATGACTACTCCTGG	OPRK1	ENSG00000082556	0.6655262201037726	[387,302]	[203,233]	3	hSpCas9	negative selection	4758529
53229812	53229834	8	+	27760321	HT1080	viability	ACTCAATGACATCGACGTCTGG	OPRK1	ENSG00000082556	1.0817132923035224	[252,197]	[140,243]	6	hSpCas9	negative selection	4758530
53234862	53234884	8	+	27760321	HT1080	viability	GAAGTCCAAAGCCTTCACGGGG	OPRK1	ENSG00000082556	0.8584981050588011	[406,317]	[321,195]	4	hSpCas9	negative selection	4758531
53229669	53229691	8	+	27760321	HT29	viability after 7 days	CCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.20881326993836025	[821,641]	[1266,1114,910]	3	hSpCas9	negative selection	4841990
53229750	53229772	8	+	27760321	HT29	viability after 7 days	GACGCAGATCTTCATGAAGAGG	OPRK1	ENSG00000082556	0.36075896104043403	[275,215]	[703,324,236]	5	hSpCas9	negative selection	4841991
53229777	53229799	8	-	27760321	HT29	viability after 7 days	CCCAGATGATGACTACTCCTGG	OPRK1	ENSG00000082556	0.33751076200029223	[387,302]	[519,746,414]	5	hSpCas9	negative selection	4841992
53229812	53229834	8	+	27760321	HT29	viability after 7 days	ACTCAATGACATCGACGTCTGG	OPRK1	ENSG00000082556	0.11900710191465624	[252,197]	[210,515,205]	1	hSpCas9	negative selection	4841993
53234862	53234884	8	+	27760321	HT29	viability after 7 days	GAAGTCCAAAGCCTTCACGGGG	OPRK1	ENSG00000082556	0.8942592663944985	[406,317]	[1221,768,663]	9	hSpCas9	negative selection	4841994
53229669	53229691	8	+	27760321	HT29	viability after 25 days	CCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.22455044895044507	[821,641]	[724,1087,1151]	2	hSpCas9	negative selection	4925453
53229750	53229772	8	+	27760321	HT29	viability after 25 days	GACGCAGATCTTCATGAAGAGG	OPRK1	ENSG00000082556	0.3670272495170782	[275,215]	[396,266,427]	4	hSpCas9	negative selection	4925454
53229777	53229799	8	-	27760321	HT29	viability after 25 days	CCCAGATGATGACTACTCCTGG	OPRK1	ENSG00000082556	0.3526822525446959	[387,302]	[384,529,615]	4	hSpCas9	negative selection	4925455
53229812	53229834	8	+	27760321	HT29	viability after 25 days	ACTCAATGACATCGACGTCTGG	OPRK1	ENSG00000082556	0.22779347887732887	[252,197]	[177,448,283]	2	hSpCas9	negative selection	4925456
53234862	53234884	8	+	27760321	HT29	viability after 25 days	GAAGTCCAAAGCCTTCACGGGG	OPRK1	ENSG00000082556	0.8820730939140994	[406,317]	[963,608,696]	8	hSpCas9	negative selection	4925457
53229669	53229691	8	+	27760321	HT29	viability after 22 days	CCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.27424139488304555	[821,641]	[826,1076,1172]	3	hSpCas9	negative selection	5008916
53229750	53229772	8	+	27760321	HT29	viability after 22 days	GACGCAGATCTTCATGAAGAGG	OPRK1	ENSG00000082556	0.2741528668409419	[275,215]	[318,322,390]	3	hSpCas9	negative selection	5008917
53229777	53229799	8	-	27760321	HT29	viability after 22 days	CCCAGATGATGACTACTCCTGG	OPRK1	ENSG00000082556	0.5709085462491614	[387,302]	[440,655,687]	6	hSpCas9	negative selection	5008918
53229812	53229834	8	+	27760321	HT29	viability after 22 days	ACTCAATGACATCGACGTCTGG	OPRK1	ENSG00000082556	0.31454668462484453	[252,197]	[351,399,218]	3	hSpCas9	negative selection	5008919
53234862	53234884	8	+	27760321	HT29	viability after 22 days	GAAGTCCAAAGCCTTCACGGGG	OPRK1	ENSG00000082556	0.9049649270988158	[406,317]	[753,823,776]	9	hSpCas9	negative selection	5008920
53229669	53229691	8	+	27760321	HT29	viability after 19 days	CCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.26185400490830935	[821,641]	[789,968,1220]	2	hSpCas9	negative selection	5092379
53229750	53229772	8	+	27760321	HT29	viability after 19 days	GACGCAGATCTTCATGAAGAGG	OPRK1	ENSG00000082556	0.04987655771811067	[275,215]	[480,106,304]	0	hSpCas9	negative selection	5092380
53229777	53229799	8	-	27760321	HT29	viability after 19 days	CCCAGATGATGACTACTCCTGG	OPRK1	ENSG00000082556	0.06328696489585385	[387,302]	[606,354,300]	0	hSpCas9	negative selection	5092381
53229812	53229834	8	+	27760321	HT29	viability after 19 days	ACTCAATGACATCGACGTCTGG	OPRK1	ENSG00000082556	0.8285331625580926	[252,197]	[393,589,385]	8	hSpCas9	negative selection	5092382
53234862	53234884	8	+	27760321	HT29	viability after 19 days	GAAGTCCAAAGCCTTCACGGGG	OPRK1	ENSG00000082556	0.5683627852268869	[406,317]	[932,535,415]	6	hSpCas9	negative selection	5092383
53229669	53229691	8	+	27760321	HT29	viability after 16 days	CCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.20165866843327973	[821,641]	[1064,1059,708]	2	hSpCas9	negative selection	5175842
53229750	53229772	8	+	27760321	HT29	viability after 16 days	GACGCAGATCTTCATGAAGAGG	OPRK1	ENSG00000082556	0.4244051149628851	[275,215]	[317,420,362]	5	hSpCas9	negative selection	5175843
53229777	53229799	8	-	27760321	HT29	viability after 16 days	CCCAGATGATGACTACTCCTGG	OPRK1	ENSG00000082556	0.5373605929785888	[387,302]	[459,500,713]	6	hSpCas9	negative selection	5175844
53229812	53229834	8	+	27760321	HT29	viability after 16 days	ACTCAATGACATCGACGTCTGG	OPRK1	ENSG00000082556	0.35460399272632726	[252,197]	[375,395,198]	4	hSpCas9	negative selection	5175845
53234862	53234884	8	+	27760321	HT29	viability after 16 days	GAAGTCCAAAGCCTTCACGGGG	OPRK1	ENSG00000082556	0.6504031353652326	[406,317]	[853,609,466]	7	hSpCas9	negative selection	5175846
53229669	53229691	8	+	27760321	HT29	viability after 13 days	CCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.29964794201157985	[821,641]	[1005,1003,1120]	4	hSpCas9	negative selection	5259305
53229750	53229772	8	+	27760321	HT29	viability after 13 days	GACGCAGATCTTCATGAAGAGG	OPRK1	ENSG00000082556	0.013401651743124576	[275,215]	[413,247,206]	0	hSpCas9	negative selection	5259306
53229777	53229799	8	-	27760321	HT29	viability after 13 days	CCCAGATGATGACTACTCCTGG	OPRK1	ENSG00000082556	0.3247091761170332	[387,302]	[626,399,479]	4	hSpCas9	negative selection	5259307
53229812	53229834	8	+	27760321	HT29	viability after 13 days	ACTCAATGACATCGACGTCTGG	OPRK1	ENSG00000082556	0.07359807215571934	[252,197]	[171,306,342]	0	hSpCas9	negative selection	5259308
53234862	53234884	8	+	27760321	HT29	viability after 13 days	GAAGTCCAAAGCCTTCACGGGG	OPRK1	ENSG00000082556	0.6575525257686461	[406,317]	[585,616,779]	8	hSpCas9	negative selection	5259309
53229669	53229691	8	+	27760321	HT29	viability after 10 days	CCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.21994440384745428	[821,641]	[918,1222,1055]	3	hSpCas9	negative selection	5342768
53229750	53229772	8	+	27760321	HT29	viability after 10 days	GACGCAGATCTTCATGAAGAGG	OPRK1	ENSG00000082556	0.02944546327686892	[275,215]	[240,274,420]	0	hSpCas9	negative selection	5342769
53229777	53229799	8	-	27760321	HT29	viability after 10 days	CCCAGATGATGACTACTCCTGG	OPRK1	ENSG00000082556	0.17461411492282697	[387,302]	[300,597,562]	2	hSpCas9	negative selection	5342770
53229812	53229834	8	+	27760321	HT29	viability after 10 days	ACTCAATGACATCGACGTCTGG	OPRK1	ENSG00000082556	0.36982658024055237	[252,197]	[353,476,265]	5	hSpCas9	negative selection	5342771
53234862	53234884	8	+	27760321	HT29	viability after 10 days	GAAGTCCAAAGCCTTCACGGGG	OPRK1	ENSG00000082556	0.2963292081807564	[406,317]	[641,628,401]	4	hSpCas9	negative selection	5342772
53229669	53229691	8	+	27760321	MOLM13	viability	CCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	-0.7418786142247935	[1005,821]	[315,298]	-4	hSpCas9	negative selection	5426231
53229750	53229772	8	+	27760321	MOLM13	viability	GACGCAGATCTTCATGAAGAGG	OPRK1	ENSG00000082556	-0.5564547379217429	[345,275]	[49,176]	-4	hSpCas9	negative selection	5426232
53229777	53229799	8	-	27760321	MOLM13	viability	CCCAGATGATGACTACTCCTGG	OPRK1	ENSG00000082556	-0.24982161299728217	[513,387]	[134,277]	-2	hSpCas9	negative selection	5426233
53229812	53229834	8	+	27760321	MOLM13	viability	ACTCAATGACATCGACGTCTGG	OPRK1	ENSG00000082556	0.30557909009	[264,252]	[350,35]	2	hSpCas9	negative selection	5426234
53234862	53234884	8	+	27760321	MOLM13	viability	GAAGTCCAAAGCCTTCACGGGG	OPRK1	ENSG00000082556	-1.319089555222089	[567,406]	[100,115]	-6	hSpCas9	negative selection	5426235
53251163	53251186	8	+	27661255	K562	viability	GAGCCTGCGGACTCCCACCCGGG	OPRK1	ENSG00000082556	-0.14729330367447968	[912,1079]	[816,630]	-5	dCas9-KRAB	negative selection	5498481
53251231	53251254	8	-	27661255	K562	viability	GGCGCGCCTGCTGGCCGGAAAGG	OPRK1	ENSG00000082556	0.03380634122908299	[167,245]	[179,157]	1	dCas9-KRAB	negative selection	5498482
53251312	53251335	8	-	27661255	K562	viability	GTGCCTAGAATTGGTGAGGGAGG	OPRK1	ENSG00000082556	-0.19086250832082022	[1080,918]	[784,630]	-6	dCas9-KRAB	negative selection	5498483
53251574	53251597	8	-	27661255	K562	viability	GCGGAACAGCAGCCCTCGGGCGG	OPRK1	ENSG00000082556	-0.17615488960233905	[406,514]	[323,324]	-5	dCas9-KRAB	negative selection	5498484
53251609	53251632	8	-	27661255	K562	viability	GGGAGACGTGCGCTGAGAGGCGG	OPRK1	ENSG00000082556	0.1656503321681545	[1120,1162]	[1163,901]	6	dCas9-KRAB	negative selection	5498485
53251629	53251652	8	-	27661255	K562	viability	GCAGAGCCGCCGCCAGTAGTGGG	OPRK1	ENSG00000082556	0.299201776497632	[218,239]	[208,238]	8	dCas9-KRAB	negative selection	5498486
53250821	53250844	8	-	27260156	BXPC3	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.2756471711323778	[949]	[1252,1062,1058,1457]	6	hSpCas9	negative selection	5559559
53229668	53229691	8	+	27260156	BXPC3	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	-0.04310812070297135	[562]	[517,491,641,650]	-1	hSpCas9	negative selection	5559560
53229669	53229692	8	-	27260156	BXPC3	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	0.03921407834728194	[415]	[280,479,574,469]	0	hSpCas9	negative selection	5559561
53250816	53250839	8	+	27260156	BXPC3	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.1585486134696447	[539]	[643,400,450,514]	-4	hSpCas9	negative selection	5623814
53235009	53235032	8	+	27260156	BXPC3	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.3343610487492407	[438]	[256,382,395,437]	-6	hSpCas9	negative selection	5623815
53234873	53234896	8	-	27260156	BXPC3	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.25854096566422874	[785]	[626,582,795,760]	-5	hSpCas9	negative selection	5623816
53250821	53250844	8	-	27260156	A673	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.18966953587797541	[949]	[1530,1163,1147,1394]	4	hSpCas9	negative selection	5680810
53229668	53229691	8	+	27260156	A673	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.01869299218220355	[562]	[724,709,614,692]	0	hSpCas9	negative selection	5680811
53229669	53229692	8	-	27260156	A673	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	0.1820734154864944	[415]	[730,469,527,557]	4	hSpCas9	negative selection	5680812
53250816	53250839	8	+	27260156	A673	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.32730113405220274	[539]	[494,419,502,655]	-7	hSpCas9	negative selection	5745065
53235009	53235032	8	+	27260156	A673	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.2178456148984385	[438]	[400,499,418,486]	-5	hSpCas9	negative selection	5745066
53234873	53234896	8	-	27260156	A673	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.284025106950751	[785]	[857,711,782,755]	-6	hSpCas9	negative selection	5745067
53250821	53250844	8	-	27260156	A375	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.18614600918718716	[949]	[1271,1668,1347,860]	2	hSpCas9	negative selection	5802061
53229668	53229691	8	+	27260156	A375	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.4001758392839587	[562]	[1034,784,1097,574]	6	hSpCas9	negative selection	5802062
53229669	53229692	8	-	27260156	A375	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	0.05981822261517644	[415]	[536,394,333,716]	0	hSpCas9	negative selection	5802063
53250816	53250839	8	+	27260156	A375	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.39541955714738675	[539]	[359,621,527,430]	-5	hSpCas9	negative selection	5866316
53235009	53235032	8	+	27260156	A375	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.027987251911551672	[438]	[516,576,542,395]	0	hSpCas9	negative selection	5866317
53234873	53234896	8	-	27260156	A375	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.620581285599942	[785]	[684,527,602,564]	-7	hSpCas9	negative selection	5866318
53250821	53250844	8	-	27260156	COLO741	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.1396493863551369	[949]	[1539,1226,1263]	3	hSpCas9	negative selection	5923312
53229668	53229691	8	+	27260156	COLO741	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	-0.08135173988272934	[562]	[756,738,557]	-2	hSpCas9	negative selection	5923313
53229669	53229692	8	-	27260156	COLO741	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	0.060710545662198495	[415]	[622,607,444]	1	hSpCas9	negative selection	5923314
53250816	53250839	8	+	27260156	COLO741	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.332580862823291	[539]	[654,554,448]	-6	hSpCas9	negative selection	5987567
53235009	53235032	8	+	27260156	COLO741	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.18039928007019534	[438]	[538,418,526]	-4	hSpCas9	negative selection	5987568
53234873	53234896	8	-	27260156	COLO741	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.16253534903994626	[785]	[819,820,1031]	-3	hSpCas9	negative selection	5987569
53250821	53250844	8	-	27260156	CAL120	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.05537086308723915	[949]	[1728,1245,792]	0	hSpCas9	negative selection	6044563
53229668	53229691	8	+	27260156	CAL120	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.456678790326316	[562]	[1143,666,1097]	6	hSpCas9	negative selection	6044564
53229669	53229692	8	-	27260156	CAL120	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	0.1617860655168993	[415]	[832,404,537]	2	hSpCas9	negative selection	6044565
53250816	53250839	8	+	27260156	CAL120	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.2020145882614729	[539]	[641,592,526]	-3	hSpCas9	negative selection	6108818
53235009	53235032	8	+	27260156	CAL120	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	0.055147467688592175	[438]	[394,740,540]	0	hSpCas9	negative selection	6108819
53234873	53234896	8	-	27260156	CAL120	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.49250395294370586	[785]	[719,668,699]	-6	hSpCas9	negative selection	6108820
53250821	53250844	8	-	27260156	CADOES1	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.06931860262455203	[949]	[786,972,1087,857]	1	hSpCas9	negative selection	6165814
53229668	53229691	8	+	27260156	CADOES1	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.20676769818009388	[562]	[693,474,585,663]	3	hSpCas9	negative selection	6165815
53229669	53229692	8	-	27260156	CADOES1	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	-0.01424931688164019	[415]	[583,337,298,307]	0	hSpCas9	negative selection	6165816
53250816	53250839	8	+	27260156	CADOES1	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.5241070373301184	[539]	[498,322,290,280]	-7	hSpCas9	negative selection	6230069
53235009	53235032	8	+	27260156	CADOES1	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.5501324091839249	[438]	[194,380,230,309]	-7	hSpCas9	negative selection	6230070
53234873	53234896	8	-	27260156	CADOES1	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.4520408500736301	[785]	[497,588,560,487]	-7	hSpCas9	negative selection	6230071
53250821	53250844	8	-	27260156	EWS502	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.2928465503812203	[949]	[1115,1398,1226,1187]	5	hSpCas9	negative selection	6287065
53229668	53229691	8	+	27260156	EWS502	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.249084340467835	[562]	[688,610,816,723]	4	hSpCas9	negative selection	6287066
53229669	53229692	8	-	27260156	EWS502	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	0.006814172800808871	[415]	[413,343,456,570]	0	hSpCas9	negative selection	6287067
53250816	53250839	8	+	27260156	EWS502	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.10793211099452064	[539]	[498,604,438,580]	-2	hSpCas9	negative selection	6351320
53235009	53235032	8	+	27260156	EWS502	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.2855679878589449	[438]	[261,325,491,468]	-5	hSpCas9	negative selection	6351321
53234873	53234896	8	-	27260156	EWS502	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.1620037360014821	[785]	[621,710,705,965]	-3	hSpCas9	negative selection	6351322
53250821	53250844	8	-	27260156	EW8	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.19529919721397615	[949]	[731,1123,757,914]	3	hSpCas9	negative selection	6408316
53229668	53229691	8	+	27260156	EW8	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.11509305364836048	[562]	[574,408,431,577]	2	hSpCas9	negative selection	6408317
53229669	53229692	8	-	27260156	EW8	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	0.33927383732943867	[415]	[412,486,400,406]	6	hSpCas9	negative selection	6408318
53250816	53250839	8	+	27260156	EW8	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.23856551386422947	[539]	[466,398,374,251]	-4	hSpCas9	negative selection	6472571
53235009	53235032	8	+	27260156	EW8	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.2509267497891074	[438]	[293,346,261,297]	-5	hSpCas9	negative selection	6472572
53234873	53234896	8	-	27260156	EW8	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.5298231888175458	[785]	[627,465,283,432]	-7	hSpCas9	negative selection	6472573
53250821	53250844	8	-	27260156	CORL105	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.22471621229294092	[949]	[1266,1152,1499,1310]	4	hSpCas9	negative selection	6529567
53229668	53229691	8	+	27260156	CORL105	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.08765379953238273	[562]	[771,640,781,622]	1	hSpCas9	negative selection	6529568
53229669	53229692	8	-	27260156	CORL105	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	0.19509476167962655	[415]	[522,507,617,589]	3	hSpCas9	negative selection	6529569
53250816	53250839	8	+	27260156	CORL105	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.2175705964230355	[539]	[585,510,470,596]	-4	hSpCas9	negative selection	6593822
53235009	53235032	8	+	27260156	CORL105	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.271683521674555	[438]	[398,306,584,437]	-5	hSpCas9	negative selection	6593823
53234873	53234896	8	-	27260156	CORL105	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.18412142460302372	[785]	[647,817,1009,788]	-3	hSpCas9	negative selection	6593824
53250821	53250844	8	-	27260156	HS294T	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.2215407619633123	[949]	[350,457,351,582]	3	hSpCas9	negative selection	6650818
53229668	53229691	8	+	27260156	HS294T	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.2731897305148212	[562]	[145,227,236,490]	3	hSpCas9	negative selection	6650819
53229669	53229692	8	-	27260156	HS294T	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	0.7660921908557348	[415]	[398,169,164,365]	8	hSpCas9	negative selection	6650820
53250816	53250839	8	+	27260156	HS294T	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.009080899089693811	[539]	[181,249,221,169]	0	hSpCas9	negative selection	6715073
53235009	53235032	8	+	27260156	HS294T	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.16553222052708627	[438]	[74,167,160,218]	-2	hSpCas9	negative selection	6715074
53234873	53234896	8	-	27260156	HS294T	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	0.2791371529479906	[785]	[292,580,305,278]	4	hSpCas9	negative selection	6715075
53250821	53250844	8	-	27260156	HCC44	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.20286756168766673	[949]	[1250,779,1613,1416]	3	hSpCas9	negative selection	6772069
53229668	53229691	8	+	27260156	HCC44	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.23233882917601828	[562]	[1036,529,792,692]	4	hSpCas9	negative selection	6772070
53229669	53229692	8	-	27260156	HCC44	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	-0.5727778238670203	[415]	[304,280,405,290]	-7	hSpCas9	negative selection	6772071
53250816	53250839	8	+	27260156	HCC44	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.6787445604676501	[539]	[589,325,425,220]	-7	hSpCas9	negative selection	6836324
53235009	53235032	8	+	27260156	HCC44	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.41814385345997424	[438]	[379,272,467,392]	-6	hSpCas9	negative selection	6836325
53234873	53234896	8	-	27260156	HCC44	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.6053279432618229	[785]	[799,440,584,547]	-7	hSpCas9	negative selection	6836326
53250821	53250844	8	-	27260156	G402	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.40590443587699654	[949]	[1491,1261,1631,1719]	5	hSpCas9	negative selection	6893320
53229668	53229691	8	+	27260156	G402	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.2974668236816542	[562]	[667,733,947,984]	4	hSpCas9	negative selection	6893321
53229669	53229692	8	-	27260156	G402	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	0.05952630197537133	[415]	[526,872,297,439]	0	hSpCas9	negative selection	6893322
53250816	53250839	8	+	27260156	G402	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.6718875580045772	[539]	[314,273,449,582]	-7	hSpCas9	negative selection	6957575
53235009	53235032	8	+	27260156	G402	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.2499734374058581	[438]	[951,242,417,256]	-3	hSpCas9	negative selection	6957576
53234873	53234896	8	-	27260156	G402	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.5437866585535224	[785]	[767,820,525,544]	-6	hSpCas9	negative selection	6957577
53250821	53250844	8	-	27260156	L33	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.17859404630316433	[949]	[1088,391,691,1152]	4	hSpCas9	negative selection	7014571
53229668	53229691	8	+	27260156	L33	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	-0.19197191851711104	[562]	[508,153,323,569]	-4	hSpCas9	negative selection	7014572
53229669	53229692	8	-	27260156	L33	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	0.0017598594931088896	[415]	[372,208,248,387]	0	hSpCas9	negative selection	7014573
53250816	53250839	8	+	27260156	L33	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.4214130240265575	[539]	[375,176,259,391]	-7	hSpCas9	negative selection	7078826
53235009	53235032	8	+	27260156	L33	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.0673585802540649	[438]	[365,129,320,482]	-1	hSpCas9	negative selection	7078827
53234873	53234896	8	-	27260156	L33	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.23863056340302058	[785]	[582,252,452,744]	-5	hSpCas9	negative selection	7078828
53250821	53250844	8	-	27260156	K562	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.5165670936740852	[949]	[1125,1376,1617,753]	6	hSpCas9	negative selection	7135822
53229668	53229691	8	+	27260156	K562	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.4805759235319331	[562]	[494,1030,935,363]	6	hSpCas9	negative selection	7135823
53229669	53229692	8	-	27260156	K562	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	0.159082673335517	[415]	[454,410,376,407]	2	hSpCas9	negative selection	7135824
53250816	53250839	8	+	27260156	K562	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.29254887210369296	[539]	[312,839,304,150]	-4	hSpCas9	negative selection	7200077
53235009	53235032	8	+	27260156	K562	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	0.24757962461908822	[438]	[586,794,344,181]	3	hSpCas9	negative selection	7200078
53234873	53234896	8	-	27260156	K562	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.22514920875547395	[785]	[355,536,564,870]	-3	hSpCas9	negative selection	7200079
53250821	53250844	8	-	27260156	HT29	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.1926239537226202	[949]	[1380,1505,1314,1113]	4	hSpCas9	negative selection	7257073
53229668	53229691	8	+	27260156	HT29	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	-0.07674771071030789	[562]	[827,581,557,632]	-2	hSpCas9	negative selection	7257074
53229669	53229692	8	-	27260156	HT29	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	-0.29984420207721574	[415]	[311,412,480,424]	-5	hSpCas9	negative selection	7257075
53250816	53250839	8	+	27260156	HT29	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.12527397381275934	[539]	[359,995,682,403]	-3	hSpCas9	negative selection	7321328
53235009	53235032	8	+	27260156	HT29	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.37432754326935624	[438]	[373,459,443,371]	-6	hSpCas9	negative selection	7321329
53234873	53234896	8	-	27260156	HT29	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.6045310456197318	[785]	[693,623,650,553]	-7	hSpCas9	negative selection	7321330
53250821	53250844	8	-	27260156	MHHES1	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.22246836689149507	[949]	[1602,1127,1310,1009]	4	hSpCas9	negative selection	7378324
53229668	53229691	8	+	27260156	MHHES1	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	-0.20543321077426885	[562]	[631,561,481,526]	-4	hSpCas9	negative selection	7378325
53229669	53229692	8	-	27260156	MHHES1	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	-0.03590862069124212	[415]	[562,320,290,604]	0	hSpCas9	negative selection	7378326
53250816	53250839	8	+	27260156	MHHES1	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.463734346708793	[539]	[447,630,350,361]	-7	hSpCas9	negative selection	7442579
53235009	53235032	8	+	27260156	MHHES1	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.5277684953545659	[438]	[218,359,367,391]	-7	hSpCas9	negative selection	7442580
53234873	53234896	8	-	27260156	MHHES1	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.45631863835041264	[785]	[604,692,568,687]	-7	hSpCas9	negative selection	7442581
53250821	53250844	8	-	27260156	MEWO	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.2212261295018112	[949]	[1302,976,879]	5	hSpCas9	negative selection	7499575
53229668	53229691	8	+	27260156	MEWO	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.270767411366557	[562]	[844,397,704]	6	hSpCas9	negative selection	7499576
53229669	53229692	8	-	27260156	MEWO	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	0.13399347820588914	[415]	[565,434,306]	3	hSpCas9	negative selection	7499577
53250816	53250839	8	+	27260156	MEWO	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.4813884053035068	[539]	[404,338,349]	-8	hSpCas9	negative selection	7563830
53235009	53235032	8	+	27260156	MEWO	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	0.03178725606669372	[438]	[662,336,306]	0	hSpCas9	negative selection	7563831
53234873	53234896	8	-	27260156	MEWO	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.2569930994047865	[785]	[716,542,605]	-5	hSpCas9	negative selection	7563832
53250821	53250844	8	-	27260156	LNCAPCLONEFGC	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.09730705179794841	[949]	[860,837,1065,944]	1	hSpCas9	negative selection	7620826
53229668	53229691	8	+	27260156	LNCAPCLONEFGC	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.4329348596412843	[562]	[642,756,837,533]	6	hSpCas9	negative selection	7620827
53229669	53229692	8	-	27260156	LNCAPCLONEFGC	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	-0.15472538155347226	[415]	[334,392,403,227]	-2	hSpCas9	negative selection	7620828
53250816	53250839	8	+	27260156	LNCAPCLONEFGC	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.4200223315180919	[539]	[467,310,366,317]	-6	hSpCas9	negative selection	7685081
53235009	53235032	8	+	27260156	LNCAPCLONEFGC	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.36070388361161587	[438]	[278,172,415,395]	-5	hSpCas9	negative selection	7685082
53234873	53234896	8	-	27260156	LNCAPCLONEFGC	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.6271102509929883	[785]	[481,463,419,470]	-7	hSpCas9	negative selection	7685083
53250821	53250844	8	-	27260156	PANC0327	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	-0.000708881337094569	[949]	[778,792,923,878]	0	hSpCas9	negative selection	7742077
53229668	53229691	8	+	27260156	PANC0327	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.01708526008005118	[562]	[568,476,472,513]	0	hSpCas9	negative selection	7742078
53229669	53229692	8	-	27260156	PANC0327	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	0.08723952532367198	[415]	[553,377,234,417]	1	hSpCas9	negative selection	7742079
53250816	53250839	8	+	27260156	PANC0327	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.18223248024105132	[539]	[326,176,605,604]	-3	hSpCas9	negative selection	7806332
53235009	53235032	8	+	27260156	PANC0327	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	0.044231078678043864	[438]	[752,200,355,352]	0	hSpCas9	negative selection	7806333
53234873	53234896	8	-	27260156	PANC0327	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.15905622133753616	[785]	[324,652,731,762]	-2	hSpCas9	negative selection	7806334
53250821	53250844	8	-	27260156	NCIH2009	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	-0.019423965494233975	[949]	[1417,1466,1059]	0	hSpCas9	negative selection	7863328
53229668	53229691	8	+	27260156	NCIH2009	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.2712739807540804	[562]	[1527,769,665]	4	hSpCas9	negative selection	7863329
53229669	53229692	8	-	27260156	NCIH2009	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	-0.20871590745979496	[415]	[512,443,553]	-3	hSpCas9	negative selection	7863330
53250816	53250839	8	+	27260156	NCIH2009	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.2070902169462969	[539]	[731,825,413]	-3	hSpCas9	negative selection	7927583
53235009	53235032	8	+	27260156	NCIH2009	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.18229133838975292	[438]	[644,505,490]	-3	hSpCas9	negative selection	7927584
53234873	53234896	8	-	27260156	NCIH2009	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.3329272894517028	[785]	[1164,818,688]	-4	hSpCas9	negative selection	7927585
53250821	53250844	8	-	27260156	NCIH1373	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.0729123621632326	[949]	[909,1017,1297,322]	0	hSpCas9	negative selection	7984579
53229668	53229691	8	+	27260156	NCIH1373	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.4470318893187679	[562]	[902,463,802,353]	4	hSpCas9	negative selection	7984580
53229669	53229692	8	-	27260156	NCIH1373	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	0.2085526718833142	[415]	[432,569,426,187]	2	hSpCas9	negative selection	7984581
53250816	53250839	8	+	27260156	NCIH1373	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.529253105915312	[539]	[737,245,328,113]	-5	hSpCas9	negative selection	8048834
53235009	53235032	8	+	27260156	NCIH1373	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.1454990357323614	[438]	[618,358,345,129]	-1	hSpCas9	negative selection	8048835
53234873	53234896	8	-	27260156	NCIH1373	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.5540131049846537	[785]	[646,478,880,102]	-5	hSpCas9	negative selection	8048836
53250821	53250844	8	-	27260156	PATU8902	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	-0.029200602217119398	[949]	[1568,944,801,2076]	0	hSpCas9	negative selection	8105830
53229668	53229691	8	+	27260156	PATU8902	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.18934363542274657	[562]	[790,802,818,1214]	2	hSpCas9	negative selection	8105831
53229669	53229692	8	-	27260156	PATU8902	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	-0.39958654076217065	[415]	[513,480,292,510]	-4	hSpCas9	negative selection	8105832
53250816	53250839	8	+	27260156	PATU8902	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.2998403877631955	[539]	[1015,387,451,618]	-3	hSpCas9	negative selection	8170085
53235009	53235032	8	+	27260156	PATU8902	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-1.1003229994277557	[438]	[187,113,445,357]	-7	hSpCas9	negative selection	8170086
53234873	53234896	8	-	27260156	PATU8902	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-1.7635282653328899	[785]	[298,142,370,479]	-8	hSpCas9	negative selection	8170087
53250821	53250844	8	-	27260156	PANC1	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.3972414866124656	[949]	[775,1490,1247,889]	6	hSpCas9	negative selection	8227081
53229668	53229691	8	+	27260156	PANC1	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	-0.2529971939123636	[562]	[409,653,423,211]	-4	hSpCas9	negative selection	8227082
53229669	53229692	8	-	27260156	PANC1	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	-0.37595699976105784	[415]	[352,252,202,279]	-5	hSpCas9	negative selection	8227083
53250816	53250839	8	+	27260156	PANC1	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.5334213556777919	[539]	[362,509,239,217]	-7	hSpCas9	negative selection	8291336
53235009	53235032	8	+	27260156	PANC1	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.4945049590292245	[438]	[233,499,195,195]	-6	hSpCas9	negative selection	8291337
53234873	53234896	8	-	27260156	PANC1	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-1.2017494606590544	[785]	[285,328,331,238]	-9	hSpCas9	negative selection	8291338
53250821	53250844	8	-	27260156	PANC0813	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.3364020771368428	[949]	[1626,1360,1411,1261]	5	hSpCas9	negative selection	8348332
53229668	53229691	8	+	27260156	PANC0813	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.04667448082368164	[562]	[1056,596,692,432]	0	hSpCas9	negative selection	8348333
53229669	53229692	8	-	27260156	PANC0813	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	-0.0895080061483941	[415]	[544,506,425,370]	-1	hSpCas9	negative selection	8348334
53250816	53250839	8	+	27260156	PANC0813	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	0.1506705466393454	[539]	[792,648,771,614]	2	hSpCas9	negative selection	8412587
53235009	53235032	8	+	27260156	PANC0813	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.30065167267194237	[438]	[462,357,400,453]	-5	hSpCas9	negative selection	8412588
53234873	53234896	8	-	27260156	PANC0813	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.01092846428003047	[785]	[696,1012,968,961]	0	hSpCas9	negative selection	8412589
53250821	53250844	8	-	27260156	RDES	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	-0.0038363937942027526	[949]	[789,1057,1233,1359]	0	hSpCas9	negative selection	8469583
53229668	53229691	8	+	27260156	RDES	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.1778200962522492	[562]	[800,643,770,672]	3	hSpCas9	negative selection	8469584
53229669	53229692	8	-	27260156	RDES	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	-0.20414685909691	[415]	[332,385,487,473]	-3	hSpCas9	negative selection	8469585
53250816	53250839	8	+	27260156	RDES	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.6011628208718601	[539]	[355,380,342,582]	-8	hSpCas9	negative selection	8533838
53235009	53235032	8	+	27260156	RDES	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.44383676014931756	[438]	[308,389,380,410]	-6	hSpCas9	negative selection	8533839
53234873	53234896	8	-	27260156	RDES	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.7741950951003891	[785]	[407,386,601,783]	-8	hSpCas9	negative selection	8533840
53250821	53250844	8	-	27260156	PC3	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.30846481556751404	[949]	[863,1080,1968,1091]	6	hSpCas9	negative selection	8590834
53229668	53229691	8	+	27260156	PC3	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	-0.04470151222225241	[562]	[408,450,940,531]	-1	hSpCas9	negative selection	8590835
53229669	53229692	8	-	27260156	PC3	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	-0.5270277901299201	[415]	[199,169,501,381]	-8	hSpCas9	negative selection	8590836
53250816	53250839	8	+	27260156	PC3	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.24261709839278636	[539]	[281,344,798,571]	-5	hSpCas9	negative selection	8655089
53235009	53235032	8	+	27260156	PC3	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.4634139143539289	[438]	[275,271,475,284]	-8	hSpCas9	negative selection	8655090
53234873	53234896	8	-	27260156	PC3	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	0.023286420526324902	[785]	[478,743,1416,856]	0	hSpCas9	negative selection	8655091
53250821	53250844	8	-	27260156	PATU8988T	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.30068002659920556	[949]	[1153,1028,1111,1225]	5	hSpCas9	negative selection	8712085
53229668	53229691	8	+	27260156	PATU8988T	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	-0.3491692165810448	[562]	[393,506,380,434]	-5	hSpCas9	negative selection	8712086
53229669	53229692	8	-	27260156	PATU8988T	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	-0.03471486750025796	[415]	[448,341,303,477]	0	hSpCas9	negative selection	8712087
53250816	53250839	8	+	27260156	PATU8988T	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.273330165088113	[539]	[330,350,631,399]	-4	hSpCas9	negative selection	8776340
53235009	53235032	8	+	27260156	PATU8988T	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.4991900809277611	[438]	[312,254,335,290]	-7	hSpCas9	negative selection	8776341
53234873	53234896	8	-	27260156	PATU8988T	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.6501626814846152	[785]	[457,558,494,425]	-7	hSpCas9	negative selection	8776342
53250821	53250844	8	-	27260156	T47D	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.09865073447380235	[949]	[1160,1003,1261,1331]	2	hSpCas9	negative selection	8833336
53229668	53229691	8	+	27260156	T47D	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.09687470178077823	[562]	[631,616,820,741]	2	hSpCas9	negative selection	8833337
53229669	53229692	8	-	27260156	T47D	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	-0.1233730997624986	[415]	[476,337,479,494]	-3	hSpCas9	negative selection	8833338
53250816	53250839	8	+	27260156	T47D	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.43592038520377474	[539]	[502,434,395,531]	-7	hSpCas9	negative selection	8897591
53235009	53235032	8	+	27260156	T47D	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.044651553675860725	[438]	[581,404,432,574]	-1	hSpCas9	negative selection	8897592
53234873	53234896	8	-	27260156	T47D	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.6283025732130905	[785]	[604,502,672,594]	-8	hSpCas9	negative selection	8897593
53250821	53250844	8	-	27260156	SU8686	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.20259716107522108	[949]	[1178,895,1064,1222]	3	hSpCas9	negative selection	8954587
53229668	53229691	8	+	27260156	SU8686	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.10714274464708218	[562]	[618,536,594,665]	1	hSpCas9	negative selection	8954588
53229669	53229692	8	-	27260156	SU8686	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	0.029718531155539712	[415]	[391,408,346,557]	0	hSpCas9	negative selection	8954589
53250816	53250839	8	+	27260156	SU8686	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.2105514322053319	[539]	[406,339,517,633]	-4	hSpCas9	negative selection	9018842
53235009	53235032	8	+	27260156	SU8686	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.11013170160304302	[438]	[359,348,394,539]	-2	hSpCas9	negative selection	9018843
53234873	53234896	8	-	27260156	SU8686	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.27031833103944797	[785]	[602,431,719,900]	-4	hSpCas9	negative selection	9018844
53250821	53250844	8	-	27260156	SKES1	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.020853490721058687	[949]	[1029,1069,961,813]	0	hSpCas9	negative selection	9075838
53229668	53229691	8	+	27260156	SKES1	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	-0.032945243062541485	[562]	[609,643,484,479]	0	hSpCas9	negative selection	9075839
53229669	53229692	8	-	27260156	SKES1	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	-0.045579035714784555	[415]	[396,556,415,267]	-1	hSpCas9	negative selection	9075840
53250816	53250839	8	+	27260156	SKES1	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.3999195616797184	[539]	[489,369,440,341]	-7	hSpCas9	negative selection	9140093
53235009	53235032	8	+	27260156	SKES1	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.26365120356754496	[438]	[388,237,427,384]	-5	hSpCas9	negative selection	9140094
53234873	53234896	8	-	27260156	SKES1	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.20031087938885384	[785]	[679,535,920,576]	-4	hSpCas9	negative selection	9140095
53250821	53250844	8	-	27260156	TOV112D	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.29814705138450304	[949]	[1171,1506,955,1126]	5	hSpCas9	negative selection	9197089
53229668	53229691	8	+	27260156	TOV112D	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	-0.09596164568345528	[562]	[548,518,688,356]	-2	hSpCas9	negative selection	9197090
53229669	53229692	8	-	27260156	TOV112D	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	-0.040943168636141364	[415]	[468,645,345,227]	-1	hSpCas9	negative selection	9197091
53250816	53250839	8	+	27260156	TOV112D	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.23222340145372597	[539]	[368,586,469,438]	-4	hSpCas9	negative selection	9261344
53235009	53235032	8	+	27260156	TOV112D	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.4401785210252985	[438]	[233,382,410,275]	-7	hSpCas9	negative selection	9261345
53234873	53234896	8	-	27260156	TOV112D	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.18158968313478463	[785]	[876,844,634,476]	-4	hSpCas9	negative selection	9261346
53250821	53250844	8	-	27260156	TC71	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.008743489460253828	[949]	[917,937,1175,1065]	0	hSpCas9	negative selection	9318340
53229668	53229691	8	+	27260156	TC71	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	-0.17687415083089147	[562]	[389,583,513,658]	-5	hSpCas9	negative selection	9318341
53229669	53229692	8	-	27260156	TC71	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	-0.00554717761733825	[415]	[399,570,408,395]	0	hSpCas9	negative selection	9318342
53250816	53250839	8	+	27260156	TC71	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.48005602760181665	[539]	[407,371,458,419]	-8	hSpCas9	negative selection	9382595
53235009	53235032	8	+	27260156	TC71	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.3748097429888304	[438]	[401,297,336,417]	-8	hSpCas9	negative selection	9382596
53234873	53234896	8	-	27260156	TC71	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.24223109282475735	[785]	[778,657,610,808]	-6	hSpCas9	negative selection	9382597
53250821	53250844	8	-	27260156	TC32	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.005644954918455403	[949]	[920,545,1328,944]	0	hSpCas9	negative selection	9439591
53229668	53229691	8	+	27260156	TC32	viability	GCCGGACGCTCTTGAGACGCAGG	OPRK1	ENSG00000082556	0.07101444471451207	[562]	[504,387,739,665]	1	hSpCas9	negative selection	9439592
53229669	53229692	8	-	27260156	TC32	viability	TCCTGCGTCTCAAGAGCGTCCGG	OPRK1	ENSG00000082556	-0.20114082838560177	[415]	[343,208,546,324]	-4	hSpCas9	negative selection	9439593
53250816	53250839	8	+	27260156	TC32	viability	CAAGCCCACGACGAACACTACGG	OPRK1	ENSG00000082556	-0.5356506500828312	[539]	[288,306,468,358]	-8	hSpCas9	negative selection	9503846
53235009	53235032	8	+	27260156	TC32	viability	CAAGTAGACCGTACTCTGAAAGG	OPRK1	ENSG00000082556	-0.30719160205275564	[438]	[328,330,300,346]	-5	hSpCas9	negative selection	9503847
53234873	53234896	8	-	27260156	TC32	viability	TGCCGTGTGCCACCCCGTGAAGG	OPRK1	ENSG00000082556	-0.6792197316575734	[785]	[551,241,650,478]	-8	hSpCas9	negative selection	9503848
53229614	53229637	8	-	27869803	HPAFII	viability after 27 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	0.010042614567676633	[628]	[290,367,NaN]	0	hSpCas9	negative selection	9602831
53229644	53229667	8	+	27869803	HPAFII	viability after 27 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.7307545697399305	[560]	[525,458,NaN]	6	hSpCas9	negative selection	9602832
53235015	53235038	8	+	27869803	HPAFII	viability after 27 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	0.9275804543757036	[74]	[80,69,NaN]	7	hSpCas9	negative selection	9602833
53242838	53242861	8	-	27869803	HPAFII	viability after 27 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	-1.81799093035818	[213]	[50,15,NaN]	-8	hSpCas9	negative selection	9602834
53250846	53250869	8	+	27869803	HPAFII	viability after 27 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	0.31172707102635133	[544]	[515,221,NaN]	2	hSpCas9	negative selection	9602835
53250919	53250942	8	-	27869803	HPAFII	viability after 27 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	-0.011545332522856055	[539]	[411,172,NaN]	0	hSpCas9	negative selection	9602836
53229614	53229637	8	-	27869803	HPAFII	viability after 15 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	0.12334317403675676	[628]	[834,674,NaN]	1	hSpCas9	negative selection	9685280
53229644	53229667	8	+	27869803	HPAFII	viability after 15 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.45354015877949694	[560]	[1083,664,NaN]	5	hSpCas9	negative selection	9685281
53235015	53235038	8	+	27869803	HPAFII	viability after 15 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	0.7659831303050028	[74]	[178,110,NaN]	8	hSpCas9	negative selection	9685282
53242838	53242861	8	-	27869803	HPAFII	viability after 15 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	-0.17165464171347783	[213]	[300,143,NaN]	-2	hSpCas9	negative selection	9685283
53250846	53250869	8	+	27869803	HPAFII	viability after 15 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	0.12633115610000467	[544]	[782,549,NaN]	1	hSpCas9	negative selection	9685284
53250919	53250942	8	-	27869803	HPAFII	viability after 15 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	-0.05349731295771898	[539]	[1025,268,NaN]	0	hSpCas9	negative selection	9685285
53229614	53229637	8	-	27869803	ASPC1	viability after 36 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	0.22277382463207973	[1211]	[565,786,204]	2	hSpCas9	negative selection	9767729
53229644	53229667	8	+	27869803	ASPC1	viability after 36 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.46478272744694116	[1365]	[928,564,534]	4	hSpCas9	negative selection	9767730
53235015	53235038	8	+	27869803	ASPC1	viability after 36 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	0.21800475443648737	[213]	[136,0,118]	2	hSpCas9	negative selection	9767731
53242838	53242861	8	-	27869803	ASPC1	viability after 36 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	0.10131272635134453	[497]	[32,187,290]	1	hSpCas9	negative selection	9767732
53250846	53250869	8	+	27869803	ASPC1	viability after 36 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	-0.8613731605611581	[1205]	[300,156,239]	-7	hSpCas9	negative selection	9767733
53250919	53250942	8	-	27869803	ASPC1	viability after 36 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	0.8342283272344768	[1015]	[722,1003,266]	7	hSpCas9	negative selection	9767734
53229614	53229637	8	-	27869803	PATU8988S	viability after 35 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	-0.07290556176151142	[1110]	[383,466,NaN]	0	hSpCas9	negative selection	9850178
53229644	53229667	8	+	27869803	PATU8988S	viability after 35 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.5177871823385056	[1259]	[755,696,NaN]	6	hSpCas9	negative selection	9850179
53235015	53235038	8	+	27869803	PATU8988S	viability after 35 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	1.3368915321118071	[141]	[129,158,NaN]	9	hSpCas9	negative selection	9850180
53242838	53242861	8	-	27869803	PATU8988S	viability after 35 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	0.31103608731397886	[417]	[144,272,NaN]	3	hSpCas9	negative selection	9850181
53250846	53250869	8	+	27869803	PATU8988S	viability after 35 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	-1.449291089626968	[1027]	[202,99,NaN]	-8	hSpCas9	negative selection	9850182
53250919	53250942	8	-	27869803	PATU8988S	viability after 35 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	-0.6899188816601085	[916]	[201,255,NaN]	-6	hSpCas9	negative selection	9850183
53229614	53229637	8	-	27869803	PATU8988S	viability after 31 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	-0.15171009294553317	[1110]	[323,493,NaN]	-2	hSpCas9	negative selection	9932627
53229644	53229667	8	+	27869803	PATU8988S	viability after 31 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.3941067011077317	[1259]	[661,657,NaN]	5	hSpCas9	negative selection	9932628
53235015	53235038	8	+	27869803	PATU8988S	viability after 31 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	1.525127069713797	[141]	[180,139,NaN]	9	hSpCas9	negative selection	9932629
53242838	53242861	8	-	27869803	PATU8988S	viability after 31 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	0.7726514745001591	[417]	[227,356,NaN]	8	hSpCas9	negative selection	9932630
53250846	53250869	8	+	27869803	PATU8988S	viability after 31 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	-1.1748180175509098	[1027]	[203,152,NaN]	-8	hSpCas9	negative selection	9932631
53250919	53250942	8	-	27869803	PATU8988S	viability after 31 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	-0.8402506080826094	[916]	[161,257,NaN]	-7	hSpCas9	negative selection	9932632
53229614	53229637	8	-	27869803	HPAFII	viability after 35 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	-0.17063292753371928	[628]	[217,355,NaN]	-1	hSpCas9	negative selection	10015076
53229644	53229667	8	+	27869803	HPAFII	viability after 35 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.47870955235502377	[560]	[383,408,NaN]	3	hSpCas9	negative selection	10015077
53235015	53235038	8	+	27869803	HPAFII	viability after 35 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	0.3188574059716127	[74]	[60,31,NaN]	2	hSpCas9	negative selection	10015078
53242838	53242861	8	-	27869803	HPAFII	viability after 35 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	-1.7998575027595425	[213]	[24,37,NaN]	-7	hSpCas9	negative selection	10015079
53250846	53250869	8	+	27869803	HPAFII	viability after 35 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	-0.015705434901480686	[544]	[342,193,NaN]	0	hSpCas9	negative selection	10015080
53250919	53250942	8	-	27869803	HPAFII	viability after 35 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	-0.1364895684454167	[539]	[227,271,NaN]	-1	hSpCas9	negative selection	10015081
53229614	53229637	8	-	27869803	HPAFII	viability after 31 days	CCTGCGTAGGATCACCAGACTGG	OPRK1	ENSG00000082556	0.03581686389533356	[628]	[213,522,NaN]	0	hSpCas9	negative selection	10097525
53229644	53229667	8	+	27869803	HPAFII	viability after 31 days	CTTTCTCTCGGGAGCCAGAAAGG	OPRK1	ENSG00000082556	0.835537105689323	[560]	[535,589,NaN]	6	hSpCas9	negative selection	10097526
53235015	53235038	8	+	27869803	HPAFII	viability after 31 days	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	0.8928583326169901	[74]	[103,49,NaN]	6	hSpCas9	negative selection	10097527
53242838	53242861	8	-	27869803	HPAFII	viability after 31 days	AAAGGGACTGGTGTGAAGCCGGG	OPRK1	ENSG00000082556	-1.621373023111589	[213]	[50,25,NaN]	-7	hSpCas9	negative selection	10097528
53250846	53250869	8	+	27869803	HPAFII	viability after 31 days	CGCCGTGATGATGACCGGGATGG	OPRK1	ENSG00000082556	0.1625267796184673	[544]	[427,248,NaN]	1	hSpCas9	negative selection	10097529
53250919	53250942	8	-	27869803	HPAFII	viability after 31 days	TGGGCCGAGCCCGACAGCAACGG	OPRK1	ENSG00000082556	0.1656434197273149	[539]	[382,292,NaN]	1	hSpCas9	negative selection	10097530
53234758	53234781	8	-	28162770	P31FUJ	viability	GGAGGCACCAAAGTCAGGGAAGG	OPRK1	ENSG00000082556	0.19346255028771908	[95]	[128]	2	hSpCas9	negative selection	10204917
53235015	53235038	8	+	28162770	P31FUJ	viability	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	0.4064714161846015	[390]	[608]	4	hSpCas9	negative selection	10204918
53250852	53250875	8	+	28162770	P31FUJ	viability	GATGATGACCGGGATGGCCGGGG	OPRK1	ENSG00000082556	0.7092504463763418	[126]	[243]	7	hSpCas9	negative selection	10204919
53250939	53250962	8	-	28162770	P31FUJ	viability	GCAGCGCCTGGTTTCCCGGCTGG	OPRK1	ENSG00000082556	0.7883969612914536	[303]	[616]	8	hSpCas9	negative selection	10204920
53250865	53250888	8	+	28162770	P31FUJ	viability	ATGGCCGGGGAGATGTGCGCGGG	OPRK1	ENSG00000082556	0.692054937723589	[265]	[504]	7	hSpCas9	negative selection	10204921
53250910	53250933	8	-	28162770	P31FUJ	viability	CCCGACAGCAACGGCAGCGCCGG	OPRK1	ENSG00000082556	0.42444915711365716	[252]	[398]	5	hSpCas9	negative selection	10204922
53234864	53234887	8	+	28162770	P31FUJ	viability	AGTCCAAAGCCTTCACGGGGTGG	OPRK1	ENSG00000082556	0.4275054212224195	[142]	[225]	5	hSpCas9	negative selection	10204923
53251009	53251032	8	-	28162770	P31FUJ	viability	TCCCCGATCCAGATCTTCCGCGG	OPRK1	ENSG00000082556	0.4637021218133681	[592]	[960]	5	hSpCas9	negative selection	10204924
53250821	53250844	8	-	28162770	P31FUJ	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.5798822214538848	[192]	[338]	6	hSpCas9	negative selection	10204925
53234882	53234905	8	+	28162770	P31FUJ	viability	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	0.047305714778356434	[503]	[611]	0	hSpCas9	negative selection	10204926
53234758	53234781	8	-	28162770	TF1	viability	GGAGGCACCAAAGTCAGGGAAGG	OPRK1	ENSG00000082556	NaN	[NaN]	[50]	1	hSpCas9	negative selection	10374283
53235015	53235038	8	+	28162770	TF1	viability	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	NaN	[NaN]	[229]	1	hSpCas9	negative selection	10374284
53250852	53250875	8	+	28162770	TF1	viability	GATGATGACCGGGATGGCCGGGG	OPRK1	ENSG00000082556	NaN	[NaN]	[147]	1	hSpCas9	negative selection	10374285
53250939	53250962	8	-	28162770	TF1	viability	GCAGCGCCTGGTTTCCCGGCTGG	OPRK1	ENSG00000082556	NaN	[NaN]	[546]	1	hSpCas9	negative selection	10374286
53250865	53250888	8	+	28162770	TF1	viability	ATGGCCGGGGAGATGTGCGCGGG	OPRK1	ENSG00000082556	NaN	[NaN]	[355]	1	hSpCas9	negative selection	10374287
53250910	53250933	8	-	28162770	TF1	viability	CCCGACAGCAACGGCAGCGCCGG	OPRK1	ENSG00000082556	NaN	[NaN]	[167]	1	hSpCas9	negative selection	10374288
53234864	53234887	8	+	28162770	TF1	viability	AGTCCAAAGCCTTCACGGGGTGG	OPRK1	ENSG00000082556	NaN	[NaN]	[224]	1	hSpCas9	negative selection	10374289
53251009	53251032	8	-	28162770	TF1	viability	TCCCCGATCCAGATCTTCCGCGG	OPRK1	ENSG00000082556	NaN	[NaN]	[528]	1	hSpCas9	negative selection	10374290
53250821	53250844	8	-	28162770	TF1	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	NaN	[NaN]	[265]	1	hSpCas9	negative selection	10374291
53234882	53234905	8	+	28162770	TF1	viability	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	NaN	[NaN]	[384]	1	hSpCas9	negative selection	10374292
53234758	53234781	8	-	28162770	SKM1	viability	GGAGGCACCAAAGTCAGGGAAGG	OPRK1	ENSG00000082556	0.4999263968653569	[25]	[64]	5	hSpCas9	negative selection	10543649
53235015	53235038	8	+	28162770	SKM1	viability	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	0.6615155391396048	[107]	[301]	6	hSpCas9	negative selection	10543650
53250852	53250875	8	+	28162770	SKM1	viability	GATGATGACCGGGATGGCCGGGG	OPRK1	ENSG00000082556	-0.4312117449898391	[44]	[58]	-4	hSpCas9	negative selection	10543651
53250939	53250962	8	-	28162770	SKM1	viability	GCAGCGCCTGGTTTCCCGGCTGG	OPRK1	ENSG00000082556	0.7309706884547136	[75]	[222]	7	hSpCas9	negative selection	10543652
53250865	53250888	8	+	28162770	SKM1	viability	ATGGCCGGGGAGATGTGCGCGGG	OPRK1	ENSG00000082556	0.9794526225959141	[69]	[243]	8	hSpCas9	negative selection	10543653
53250910	53250933	8	-	28162770	SKM1	viability	CCCGACAGCAACGGCAGCGCCGG	OPRK1	ENSG00000082556	-0.1669131109102071	[86]	[136]	-1	hSpCas9	negative selection	10543654
53234864	53234887	8	+	28162770	SKM1	viability	AGTCCAAAGCCTTCACGGGGTGG	OPRK1	ENSG00000082556	0.3730142843831372	[37]	[86]	3	hSpCas9	negative selection	10543655
53251009	53251032	8	-	28162770	SKM1	viability	TCCCCGATCCAGATCTTCCGCGG	OPRK1	ENSG00000082556	0.01720209007493856	[127]	[228]	0	hSpCas9	negative selection	10543656
53250821	53250844	8	-	28162770	SKM1	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.45007784741479545	[52]	[127]	4	hSpCas9	negative selection	10543657
53234882	53234905	8	+	28162770	SKM1	viability	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	0.1779983019779945	[126]	[253]	1	hSpCas9	negative selection	10543658
53234758	53234781	8	-	28162770	SKM1	viability	GGAGGCACCAAAGTCAGGGAAGG	OPRK1	ENSG00000082556	0.4999263968653569	[25]	[64]	5	hSpCas9	negative selection	10713015
53235015	53235038	8	+	28162770	SKM1	viability	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	0.6615155391396048	[107]	[301]	6	hSpCas9	negative selection	10713016
53250852	53250875	8	+	28162770	SKM1	viability	GATGATGACCGGGATGGCCGGGG	OPRK1	ENSG00000082556	-0.4312117449898391	[44]	[58]	-4	hSpCas9	negative selection	10713017
53250939	53250962	8	-	28162770	SKM1	viability	GCAGCGCCTGGTTTCCCGGCTGG	OPRK1	ENSG00000082556	0.7309706884547136	[75]	[222]	7	hSpCas9	negative selection	10713018
53250865	53250888	8	+	28162770	SKM1	viability	ATGGCCGGGGAGATGTGCGCGGG	OPRK1	ENSG00000082556	0.9794526225959141	[69]	[243]	8	hSpCas9	negative selection	10713019
53250910	53250933	8	-	28162770	SKM1	viability	CCCGACAGCAACGGCAGCGCCGG	OPRK1	ENSG00000082556	-0.1669131109102071	[86]	[136]	-1	hSpCas9	negative selection	10713020
53234864	53234887	8	+	28162770	SKM1	viability	AGTCCAAAGCCTTCACGGGGTGG	OPRK1	ENSG00000082556	0.3730142843831372	[37]	[86]	3	hSpCas9	negative selection	10713021
53251009	53251032	8	-	28162770	SKM1	viability	TCCCCGATCCAGATCTTCCGCGG	OPRK1	ENSG00000082556	0.01720209007493856	[127]	[228]	0	hSpCas9	negative selection	10713022
53250821	53250844	8	-	28162770	SKM1	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.45007784741479545	[52]	[127]	4	hSpCas9	negative selection	10713023
53234882	53234905	8	+	28162770	SKM1	viability	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	0.1779983019779945	[126]	[253]	1	hSpCas9	negative selection	10713024
53234758	53234781	8	-	28162770	PL21	viability	GGAGGCACCAAAGTCAGGGAAGG	OPRK1	ENSG00000082556	-0.022252806847127715	[125]	[53]	0	hSpCas9	negative selection	10882381
53235015	53235038	8	+	28162770	PL21	viability	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	0.9530005308171866	[342]	[288]	7	hSpCas9	negative selection	10882382
53250852	53250875	8	+	28162770	PL21	viability	GATGATGACCGGGATGGCCGGGG	OPRK1	ENSG00000082556	-0.050821959043898635	[118]	[49]	0	hSpCas9	negative selection	10882383
53250939	53250962	8	-	28162770	PL21	viability	GCAGCGCCTGGTTTCCCGGCTGG	OPRK1	ENSG00000082556	0.8512444720016882	[269]	[211]	7	hSpCas9	negative selection	10882384
53250865	53250888	8	+	28162770	PL21	viability	ATGGCCGGGGAGATGTGCGCGGG	OPRK1	ENSG00000082556	-0.6623568617607449	[239]	[65]	-4	hSpCas9	negative selection	10882385
53250910	53250933	8	-	28162770	PL21	viability	CCCGACAGCAACGGCAGCGCCGG	OPRK1	ENSG00000082556	0.8182689791456756	[214]	[164]	7	hSpCas9	negative selection	10882386
53234864	53234887	8	+	28162770	PL21	viability	AGTCCAAAGCCTTCACGGGGTGG	OPRK1	ENSG00000082556	2.2189986417406358	[75]	[153]	9	hSpCas9	negative selection	10882387
53251009	53251032	8	-	28162770	PL21	viability	TCCCCGATCCAGATCTTCCGCGG	OPRK1	ENSG00000082556	0.21456668512459975	[397]	[200]	2	hSpCas9	negative selection	10882388
53250821	53250844	8	-	28162770	PL21	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	1.1781133081593214	[131]	[129]	8	hSpCas9	negative selection	10882389
53234882	53234905	8	+	28162770	PL21	viability	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	0.7100363001096052	[308]	[219]	6	hSpCas9	negative selection	10882390
53234758	53234781	8	-	28162770	P31FUJ	viability	GGAGGCACCAAAGTCAGGGAAGG	OPRK1	ENSG00000082556	0.19346255028771908	[95]	[128]	2	hSpCas9	negative selection	11051747
53235015	53235038	8	+	28162770	P31FUJ	viability	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	0.4064714161846015	[390]	[608]	4	hSpCas9	negative selection	11051748
53250852	53250875	8	+	28162770	P31FUJ	viability	GATGATGACCGGGATGGCCGGGG	OPRK1	ENSG00000082556	0.7092504463763418	[126]	[243]	7	hSpCas9	negative selection	11051749
53250939	53250962	8	-	28162770	P31FUJ	viability	GCAGCGCCTGGTTTCCCGGCTGG	OPRK1	ENSG00000082556	0.7883969612914536	[303]	[616]	8	hSpCas9	negative selection	11051750
53250865	53250888	8	+	28162770	P31FUJ	viability	ATGGCCGGGGAGATGTGCGCGGG	OPRK1	ENSG00000082556	0.692054937723589	[265]	[504]	7	hSpCas9	negative selection	11051751
53250910	53250933	8	-	28162770	P31FUJ	viability	CCCGACAGCAACGGCAGCGCCGG	OPRK1	ENSG00000082556	0.42444915711365716	[252]	[398]	5	hSpCas9	negative selection	11051752
53234864	53234887	8	+	28162770	P31FUJ	viability	AGTCCAAAGCCTTCACGGGGTGG	OPRK1	ENSG00000082556	0.4275054212224195	[142]	[225]	5	hSpCas9	negative selection	11051753
53251009	53251032	8	-	28162770	P31FUJ	viability	TCCCCGATCCAGATCTTCCGCGG	OPRK1	ENSG00000082556	0.4637021218133681	[592]	[960]	5	hSpCas9	negative selection	11051754
53250821	53250844	8	-	28162770	P31FUJ	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.5798822214538848	[192]	[338]	6	hSpCas9	negative selection	11051755
53234882	53234905	8	+	28162770	P31FUJ	viability	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	0.047305714778356434	[503]	[611]	0	hSpCas9	negative selection	11051756
53234758	53234781	8	-	28162770	OCIAML5	viability	GGAGGCACCAAAGTCAGGGAAGG	OPRK1	ENSG00000082556	0.6471660558312753	[51]	[146]	5	hSpCas9	negative selection	11221113
53235015	53235038	8	+	28162770	OCIAML5	viability	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	1.1874617933226406	[170]	[702]	8	hSpCas9	negative selection	11221114
53250852	53250875	8	+	28162770	OCIAML5	viability	GATGATGACCGGGATGGCCGGGG	OPRK1	ENSG00000082556	0.06547126894403021	[80]	[152]	0	hSpCas9	negative selection	11221115
53250939	53250962	8	-	28162770	OCIAML5	viability	GCAGCGCCTGGTTTCCCGGCTGG	OPRK1	ENSG00000082556	0.8561673047588931	[141]	[463]	7	hSpCas9	negative selection	11221116
53250865	53250888	8	+	28162770	OCIAML5	viability	ATGGCCGGGGAGATGTGCGCGGG	OPRK1	ENSG00000082556	-0.2852188647024454	[186]	[276]	-2	hSpCas9	negative selection	11221117
53250910	53250933	8	-	28162770	OCIAML5	viability	CCCGACAGCAACGGCAGCGCCGG	OPRK1	ENSG00000082556	0.16423524146510374	[131]	[266]	1	hSpCas9	negative selection	11221118
53234864	53234887	8	+	28162770	OCIAML5	viability	AGTCCAAAGCCTTCACGGGGTGG	OPRK1	ENSG00000082556	0.9959303356909532	[74]	[269]	8	hSpCas9	negative selection	11221119
53251009	53251032	8	-	28162770	OCIAML5	viability	TCCCCGATCCAGATCTTCCGCGG	OPRK1	ENSG00000082556	-0.4726013097827344	[348]	[453]	-3	hSpCas9	negative selection	11221120
53250821	53250844	8	-	28162770	OCIAML5	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.6789183087983343	[117]	[340]	6	hSpCas9	negative selection	11221121
53234882	53234905	8	+	28162770	OCIAML5	viability	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	-0.6092753849375866	[310]	[367]	-4	hSpCas9	negative selection	11221122
53234758	53234781	8	-	28162770	EOL1	viability	GGAGGCACCAAAGTCAGGGAAGG	OPRK1	ENSG00000082556	-0.8960429776437635	[218]	[61]	-6	hSpCas9	negative selection	11390479
53235015	53235038	8	+	28162770	EOL1	viability	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	0.9466867488397832	[387]	[393]	7	hSpCas9	negative selection	11390480
53250852	53250875	8	+	28162770	EOL1	viability	GATGATGACCGGGATGGCCGGGG	OPRK1	ENSG00000082556	0.7011404398574517	[236]	[202]	6	hSpCas9	negative selection	11390481
53250939	53250962	8	-	28162770	EOL1	viability	GCAGCGCCTGGTTTCCCGGCTGG	OPRK1	ENSG00000082556	-0.14760201418530094	[491]	[233]	-1	hSpCas9	negative selection	11390482
53250865	53250888	8	+	28162770	EOL1	viability	ATGGCCGGGGAGATGTGCGCGGG	OPRK1	ENSG00000082556	-0.5731226513544545	[496]	[175]	-4	hSpCas9	negative selection	11390483
53250910	53250933	8	-	28162770	EOL1	viability	CCCGACAGCAACGGCAGCGCCGG	OPRK1	ENSG00000082556	0.5890205653473509	[452]	[358]	5	hSpCas9	negative selection	11390484
53234864	53234887	8	+	28162770	EOL1	viability	AGTCCAAAGCCTTCACGGGGTGG	OPRK1	ENSG00000082556	-0.10489600632194751	[197]	[96]	-1	hSpCas9	negative selection	11390485
53251009	53251032	8	-	28162770	EOL1	viability	TCCCCGATCCAGATCTTCCGCGG	OPRK1	ENSG00000082556	0.4816760640949651	[627]	[461]	4	hSpCas9	negative selection	11390486
53250821	53250844	8	-	28162770	EOL1	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	1.102885012829047	[189]	[214]	8	hSpCas9	negative selection	11390487
53234882	53234905	8	+	28162770	EOL1	viability	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	1.0765508650155846	[503]	[559]	8	hSpCas9	negative selection	11390488
53234758	53234781	8	-	28162770	MOLM13	viability	GGAGGCACCAAAGTCAGGGAAGG	OPRK1	ENSG00000082556	-1.0384632844802109	[124]	[43]	-5	hSpCas9	negative selection	11559845
53235015	53235038	8	+	28162770	MOLM13	viability	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	-0.7330976761885982	[445]	[193]	-4	hSpCas9	negative selection	11559846
53250852	53250875	8	+	28162770	MOLM13	viability	GATGATGACCGGGATGGCCGGGG	OPRK1	ENSG00000082556	0.2650724985448916	[182]	[158]	2	hSpCas9	negative selection	11559847
53250939	53250962	8	-	28162770	MOLM13	viability	GCAGCGCCTGGTTTCCCGGCTGG	OPRK1	ENSG00000082556	0.07268829791990378	[312]	[237]	0	hSpCas9	negative selection	11559848
53250865	53250888	8	+	28162770	MOLM13	viability	ATGGCCGGGGAGATGTGCGCGGG	OPRK1	ENSG00000082556	-0.1487819789039153	[390]	[254]	-1	hSpCas9	negative selection	11559849
53250910	53250933	8	-	28162770	MOLM13	viability	CCCGACAGCAACGGCAGCGCCGG	OPRK1	ENSG00000082556	1.045569206322039	[330]	[493]	7	hSpCas9	negative selection	11559850
53234864	53234887	8	+	28162770	MOLM13	viability	AGTCCAAAGCCTTCACGGGGTGG	OPRK1	ENSG00000082556	-0.8150445817269197	[145]	[59]	-4	hSpCas9	negative selection	11559851
53251009	53251032	8	-	28162770	MOLM13	viability	TCCCCGATCCAGATCTTCCGCGG	OPRK1	ENSG00000082556	-0.558722348702741	[765]	[375]	-3	hSpCas9	negative selection	11559852
53250821	53250844	8	-	28162770	MOLM13	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.18778146235184345	[254]	[209]	1	hSpCas9	negative selection	11559853
53234882	53234905	8	+	28162770	MOLM13	viability	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	-0.9682097332620946	[643]	[237]	-5	hSpCas9	negative selection	11559854
53234758	53234781	8	-	28162770	HEL	viability	GGAGGCACCAAAGTCAGGGAAGG	OPRK1	ENSG00000082556	0.3598048687288582	[145]	[119]	3	hSpCas9	negative selection	11729211
53235015	53235038	8	+	28162770	HEL	viability	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	-0.10586146264925245	[414]	[246]	-1	hSpCas9	negative selection	11729212
53250852	53250875	8	+	28162770	HEL	viability	GATGATGACCGGGATGGCCGGGG	OPRK1	ENSG00000082556	1.9665515712326624	[152]	[382]	9	hSpCas9	negative selection	11729213
53250939	53250962	8	-	28162770	HEL	viability	GCAGCGCCTGGTTTCCCGGCTGG	OPRK1	ENSG00000082556	0.9341505003646552	[343]	[420]	7	hSpCas9	negative selection	11729214
53250865	53250888	8	+	28162770	HEL	viability	ATGGCCGGGGAGATGTGCGCGGG	OPRK1	ENSG00000082556	0.91322554153785	[353]	[426]	7	hSpCas9	negative selection	11729215
53250910	53250933	8	-	28162770	HEL	viability	CCCGACAGCAACGGCAGCGCCGG	OPRK1	ENSG00000082556	1.2048914498134273	[339]	[501]	9	hSpCas9	negative selection	11729216
53234864	53234887	8	+	28162770	HEL	viability	AGTCCAAAGCCTTCACGGGGTGG	OPRK1	ENSG00000082556	-0.27782670050523806	[158]	[83]	-2	hSpCas9	negative selection	11729217
53251009	53251032	8	-	28162770	HEL	viability	TCCCCGATCCAGATCTTCCGCGG	OPRK1	ENSG00000082556	0.6981370706594481	[561]	[583]	6	hSpCas9	negative selection	11729218
53250821	53250844	8	-	28162770	HEL	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	-0.2766427077913587	[173]	[91]	-2	hSpCas9	negative selection	11729219
53234882	53234905	8	+	28162770	HEL	viability	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	0.13790466237086751	[463]	[326]	1	hSpCas9	negative selection	11729220
53234758	53234781	8	-	28162770	MV411	viability	GGAGGCACCAAAGTCAGGGAAGG	OPRK1	ENSG00000082556	-0.37951903860300806	[121]	[78]	-3	hSpCas9	negative selection	11898577
53235015	53235038	8	+	28162770	MV411	viability	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	1.0469045634100667	[261]	[455]	8	hSpCas9	negative selection	11898578
53250852	53250875	8	+	28162770	MV411	viability	GATGATGACCGGGATGGCCGGGG	OPRK1	ENSG00000082556	0.3274058554861904	[192]	[203]	3	hSpCas9	negative selection	11898579
53250939	53250962	8	-	28162770	MV411	viability	GCAGCGCCTGGTTTCCCGGCTGG	OPRK1	ENSG00000082556	0.6611286243541025	[267]	[356]	6	hSpCas9	negative selection	11898580
53250865	53250888	8	+	28162770	MV411	viability	ATGGCCGGGGAGATGTGCGCGGG	OPRK1	ENSG00000082556	-0.4296151419661097	[282]	[176]	-3	hSpCas9	negative selection	11898581
53250910	53250933	8	-	28162770	MV411	viability	CCCGACAGCAACGGCAGCGCCGG	OPRK1	ENSG00000082556	0.10078769183193204	[268]	[242]	0	hSpCas9	negative selection	11898582
53234864	53234887	8	+	28162770	MV411	viability	AGTCCAAAGCCTTCACGGGGTGG	OPRK1	ENSG00000082556	-0.16759994849606852	[115]	[86]	-1	hSpCas9	negative selection	11898583
53251009	53251032	8	-	28162770	MV411	viability	TCCCCGATCCAGATCTTCCGCGG	OPRK1	ENSG00000082556	0.28314161246445435	[438]	[449]	2	hSpCas9	negative selection	11898584
53250821	53250844	8	-	28162770	MV411	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	0.9267274340520846	[147]	[236]	8	hSpCas9	negative selection	11898585
53234882	53234905	8	+	28162770	MV411	viability	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	0.41511571320859575	[356]	[400]	3	hSpCas9	negative selection	11898586
53234758	53234781	8	-	28162770	MONOMAC1	viability	GGAGGCACCAAAGTCAGGGAAGG	OPRK1	ENSG00000082556	-0.053445993430703886	[85]	[94]	0	hSpCas9	negative selection	12067943
53235015	53235038	8	+	28162770	MONOMAC1	viability	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	-0.051057541242273796	[215]	[238]	0	hSpCas9	negative selection	12067944
53250852	53250875	8	+	28162770	MONOMAC1	viability	GATGATGACCGGGATGGCCGGGG	OPRK1	ENSG00000082556	0.22218844918272346	[85]	[114]	2	hSpCas9	negative selection	12067945
53250939	53250962	8	-	28162770	MONOMAC1	viability	GCAGCGCCTGGTTTCCCGGCTGG	OPRK1	ENSG00000082556	0.5592940719735834	[147]	[249]	5	hSpCas9	negative selection	12067946
53250865	53250888	8	+	28162770	MONOMAC1	viability	ATGGCCGGGGAGATGTGCGCGGG	OPRK1	ENSG00000082556	0.4951792403733538	[202]	[327]	5	hSpCas9	negative selection	12067947
53250910	53250933	8	-	28162770	MONOMAC1	viability	CCCGACAGCAACGGCAGCGCCGG	OPRK1	ENSG00000082556	-0.4998842003812114	[168]	[136]	-4	hSpCas9	negative selection	12067948
53234864	53234887	8	+	28162770	MONOMAC1	viability	AGTCCAAAGCCTTCACGGGGTGG	OPRK1	ENSG00000082556	0.3879256536616026	[79]	[119]	4	hSpCas9	negative selection	12067949
53251009	53251032	8	-	28162770	MONOMAC1	viability	TCCCCGATCCAGATCTTCCGCGG	OPRK1	ENSG00000082556	0.5408870301315163	[300]	[501]	5	hSpCas9	negative selection	12067950
53250821	53250844	8	-	28162770	MONOMAC1	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	-0.16141293732883225	[119]	[122]	-1	hSpCas9	negative selection	12067951
53234882	53234905	8	+	28162770	MONOMAC1	viability	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	0.48907237711850216	[178]	[287]	5	hSpCas9	negative selection	12067952
53234758	53234781	8	-	28162770	OCIAML2	viability	GGAGGCACCAAAGTCAGGGAAGG	OPRK1	ENSG00000082556	-0.25561693427131105	[13]	[64]	-2	hSpCas9	negative selection	12237309
53235015	53235038	8	+	28162770	OCIAML2	viability	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	-0.1629624234799686	[60]	[301]	-1	hSpCas9	negative selection	12237310
53250852	53250875	8	+	28162770	OCIAML2	viability	GATGATGACCGGGATGGCCGGGG	OPRK1	ENSG00000082556	0.21473457243683258	[36]	[237]	2	hSpCas9	negative selection	12237311
53250939	53250962	8	-	28162770	OCIAML2	viability	GCAGCGCCTGGTTTCCCGGCTGG	OPRK1	ENSG00000082556	0.6511391380454987	[43]	[382]	6	hSpCas9	negative selection	12237312
53250865	53250888	8	+	28162770	OCIAML2	viability	ATGGCCGGGGAGATGTGCGCGGG	OPRK1	ENSG00000082556	0.1398677675861324	[55]	[341]	1	hSpCas9	negative selection	12237313
53250910	53250933	8	-	28162770	OCIAML2	viability	CCCGACAGCAACGGCAGCGCCGG	OPRK1	ENSG00000082556	0.3546916433448921	[56]	[403]	3	hSpCas9	negative selection	12237314
53234864	53234887	8	+	28162770	OCIAML2	viability	AGTCCAAAGCCTTCACGGGGTGG	OPRK1	ENSG00000082556	-0.011198206604863925	[21]	[120]	0	hSpCas9	negative selection	12237315
53251009	53251032	8	-	28162770	OCIAML2	viability	TCCCCGATCCAGATCTTCCGCGG	OPRK1	ENSG00000082556	0.22258556613101832	[76]	[497]	2	hSpCas9	negative selection	12237316
53250821	53250844	8	-	28162770	OCIAML2	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	1.2074420798704764	[24]	[319]	9	hSpCas9	negative selection	12237317
53234882	53234905	8	+	28162770	OCIAML2	viability	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	0.5112228280475792	[49]	[394]	5	hSpCas9	negative selection	12237318
53234758	53234781	8	-	28162770	OCIAML3	viability	GGAGGCACCAAAGTCAGGGAAGG	OPRK1	ENSG00000082556	0.9540552775854639	[32]	[192]	8	hSpCas9	negative selection	12406675
53235015	53235038	8	+	28162770	OCIAML3	viability	GACCGTACTCTGAAAGGGCATGG	OPRK1	ENSG00000082556	0.09674952441958973	[91]	[296]	0	hSpCas9	negative selection	12406676
53250852	53250875	8	+	28162770	OCIAML3	viability	GATGATGACCGGGATGGCCGGGG	OPRK1	ENSG00000082556	1.073055940611887	[36]	[234]	8	hSpCas9	negative selection	12406677
53250939	53250962	8	-	28162770	OCIAML3	viability	GCAGCGCCTGGTTTCCCGGCTGG	OPRK1	ENSG00000082556	0.5900516453217852	[78]	[358]	5	hSpCas9	negative selection	12406678
53250865	53250888	8	+	28162770	OCIAML3	viability	ATGGCCGGGGAGATGTGCGCGGG	OPRK1	ENSG00000082556	0.5759173611181492	[49]	[224]	5	hSpCas9	negative selection	12406679
53250910	53250933	8	-	28162770	OCIAML3	viability	CCCGACAGCAACGGCAGCGCCGG	OPRK1	ENSG00000082556	0.4059923596758369	[68]	[275]	4	hSpCas9	negative selection	12406680
53234864	53234887	8	+	28162770	OCIAML3	viability	AGTCCAAAGCCTTCACGGGGTGG	OPRK1	ENSG00000082556	0.4911597429385141	[36]	[156]	4	hSpCas9	negative selection	12406681
53251009	53251032	8	-	28162770	OCIAML3	viability	TCCCCGATCCAGATCTTCCGCGG	OPRK1	ENSG00000082556	-0.07743211458325705	[143]	[411]	0	hSpCas9	negative selection	12406682
53250821	53250844	8	-	28162770	OCIAML3	viability	CTACTCCGTAGTGTTCGTCGTGG	OPRK1	ENSG00000082556	-0.6069466960316614	[55]	[110]	-4	hSpCas9	negative selection	12406683
53234882	53234905	8	+	28162770	OCIAML3	viability	GGTGGCACACGGCAATGTAGCGG	OPRK1	ENSG00000082556	0.42752552122547804	[132]	[539]	4	hSpCas9	negative selection	12406684