| 19921001 | 19921024 | 14 | + | 26627737 | DLD1 | viability | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | 0.1077531912735663 | [208] | [117,43,50] | 1 | hSpCas9 | negative selection | 787799 | 19921284 | 19921307 | 14 | + | 26627737 | DLD1 | viability | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | 0.25063801839423466 | [471] | [170,128,217] | 2 | hSpCas9 | negative selection | 787800 | 19921001 | 19921024 | 14 | + | 26627737 | GBM cells | viability after 5 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | -0.5129839168625909 | [152] | [74,39] | -7 | hSpCas9 | negative selection | 870114 | 19921284 | 19921307 | 14 | + | 26627737 | GBM cells | viability after 5 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | 0.5479253542197748 | [256] | [173,228] | 7 | hSpCas9 | negative selection | 870115 | 19921001 | 19921024 | 14 | + | 26627737 | GBM cells | viability after 13 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | 0.02383609870272485 | [152] | [122,52] | 0 | hSpCas9 | negative selection | 952429 | 19921284 | 19921307 | 14 | + | 26627737 | GBM cells | viability after 13 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | 0.2727055713262674 | [256] | [184,154] | 3 | hSpCas9 | negative selection | 952430 | 19921001 | 19921024 | 14 | + | 26627737 | GBM cells | viability after 21 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | 0.037131356788712155 | [152] | [101,69] | 0 | hSpCas9 | negative selection | 1034744 | 19921284 | 19921307 | 14 | + | 26627737 | GBM cells | viability after 21 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | 0.21019760470887597 | [256] | [160,161] | 2 | hSpCas9 | negative selection | 1034745 | 19921001 | 19921024 | 14 | + | 26627737 | RPE1 | viability after 9 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | 0.3074815207778349 | [682] | [137,427] | 2 | hSpCas9 | negative selection | 1117059 | 19921284 | 19921307 | 14 | + | 26627737 | RPE1 | viability after 9 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | 0.48928106618602674 | [859] | [473,253] | 3 | hSpCas9 | negative selection | 1117060 | 19921001 | 19921024 | 14 | + | 26627737 | RPE1 | viability after 12 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | -0.42853504586669106 | [682] | [113,159] | -3 | hSpCas9 | negative selection | 1199374 | 19921284 | 19921307 | 14 | + | 26627737 | RPE1 | viability after 12 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | 0.5979514827187251 | [859] | [407,287] | 4 | hSpCas9 | negative selection | 1199375 | 19921001 | 19921024 | 14 | + | 26627737 | RPE1 | viability after 15 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | 0.0829055278457894 | [682] | [168,238] | 0 | hSpCas9 | negative selection | 1281689 | 19921284 | 19921307 | 14 | + | 26627737 | RPE1 | viability after 15 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | 0.4917711620283256 | [859] | [505,183] | 3 | hSpCas9 | negative selection | 1281690 | 19921001 | 19921024 | 14 | + | 26627737 | RPE1 | viability after 18 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | 0.09726192502745658 | [682] | [143,253] | 0 | hSpCas9 | negative selection | 1364004 | 19921284 | 19921307 | 14 | + | 26627737 | RPE1 | viability after 18 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | 0.30378320819246674 | [859] | [387,177] | 2 | hSpCas9 | negative selection | 1364005 | 19921001 | 19921024 | 14 | + | 26627737 | HeLa | viability after 8 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | 2.0489933107859595 | [69] | [198,6,183] | 9 | hSpCas9 | negative selection | 1446319 | 19921284 | 19921307 | 14 | + | 26627737 | HeLa | viability after 8 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | 0.6876038240025593 | [301] | [215,179,237] | 6 | hSpCas9 | negative selection | 1446320 | 19921001 | 19921024 | 14 | + | 26627737 | HeLa | viability after 12 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | 1.6803893479129655 | [69] | [61,132,77] | 9 | hSpCas9 | negative selection | 1528634 | 19921284 | 19921307 | 14 | + | 26627737 | HeLa | viability after 12 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | 1.615851188454593 | [301] | [380,377,388] | 9 | hSpCas9 | negative selection | 1528635 | 19921001 | 19921024 | 14 | + | 26627737 | HeLa | viability after 15 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | 1.8751002608104361 | [69] | [141,55,115] | 9 | hSpCas9 | negative selection | 1610949 | 19921284 | 19921307 | 14 | + | 26627737 | HeLa | viability after 15 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | 0.7431718248739074 | [301] | [175,220,221] | 6 | hSpCas9 | negative selection | 1610950 | 19921001 | 19921024 | 14 | + | 26627737 | HeLa | viability after 18 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | 1.87245164824596 | [69] | [95,44,115] | 9 | hSpCas9 | negative selection | 1693264 | 19921284 | 19921307 | 14 | + | 26627737 | HeLa | viability after 18 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | 0.7385323354177409 | [301] | [119,178,221] | 6 | hSpCas9 | negative selection | 1693265 | 19921001 | 19921024 | 14 | + | 26627737 | HCT116 | viability after 6 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | 0.5975361818519266 | [286] | [46,79] | 3 | hSpCas9 | negative selection | 1775579 | 19921284 | 19921307 | 14 | + | 26627737 | HCT116 | viability after 6 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | -0.4732721010879328 | [762] | [68,95] | -3 | hSpCas9 | negative selection | 1775580 | 19921001 | 19921024 | 14 | + | 26627737 | HCT116 | viability after 8 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | -0.3567373696554189 | [244] | [61,188,64] | -4 | hSpCas9 | negative selection | 1857894 | 19921284 | 19921307 | 14 | + | 26627737 | HCT116 | viability after 8 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | 0.12043766908277659 | [365] | [133,287,233] | 1 | hSpCas9 | negative selection | 1857895 | 19921001 | 19921024 | 14 | + | 26627737 | HCT116 | viability after 9 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | 1.3607485444933458 | [286] | [107,266] | 8 | hSpCas9 | negative selection | 1940209 | 19921284 | 19921307 | 14 | + | 26627737 | HCT116 | viability after 9 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | 0.4457242686261537 | [762] | [62,446] | 3 | hSpCas9 | negative selection | 1940210 | 19921001 | 19921024 | 14 | + | 26627737 | HCT116 | viability after 12 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | -0.28780262803718093 | [244] | [120,144,49] | -3 | hSpCas9 | negative selection | 2022524 | 19921284 | 19921307 | 14 | + | 26627737 | HCT116 | viability after 12 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | 0.5507250282867879 | [365] | [290,263,288] | 5 | hSpCas9 | negative selection | 2022525 | 19921001 | 19921024 | 14 | + | 26627737 | HCT116 | viability after 15 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | -0.5161303330682399 | [244] | [65,191,33] | -5 | hSpCas9 | negative selection | 2104839 | 19921284 | 19921307 | 14 | + | 26627737 | HCT116 | viability after 15 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | 0.6336926799723934 | [365] | [479,349,168] | 6 | hSpCas9 | negative selection | 2104840 | 19921001 | 19921024 | 14 | + | 26627737 | HCT116 | viability after 18 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | 0.29479932183950536 | [244] | [112,268,40] | 2 | hSpCas9 | negative selection | 2187154 | 19921284 | 19921307 | 14 | + | 26627737 | HCT116 | viability after 18 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | 0.1537122521725396 | [365] | [188,212,186] | 1 | hSpCas9 | negative selection | 2187155 | 19920991 | 19921014 | 14 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | ATGATGACCACATAGTATAAGGG | OR4K5 | ENSG00000176281 | -0.4101553902078172 | [4,4] | [4,1] | -5 | hSpCas9 | positive selection | 3008204 | 19920921 | 19920944 | 14 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | CCATCTCCCCTCCAGTAAAAAGG | OR4K5 | ENSG00000176281 | 0.273729903108572 | [4,4] | [5,4] | 6 | hSpCas9 | positive selection | 3008205 | 19920801 | 19920824 | 14 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | GACAAATGTCAACAAAGGAAAGG | OR4K5 | ENSG00000176281 | 0.37406135938413454 | [3,3] | [3,4] | 7 | hSpCas9 | positive selection | 3008206 | 19920610 | 19920633 | 14 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | GGATAAGTCCAATTCTTCAGTGG | OR4K5 | ENSG00000176281 | 0.36546991615233954 | [3,3] | [3,4] | 7 | hSpCas9 | positive selection | 3008207 | 19920991 | 19921014 | 14 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | ATGATGACCACATAGTATAAGGG | OR4K5 | ENSG00000176281 | 0.06115518323653363 | [4,4] | [4,2] | 1 | hSpCas9 | positive selection | 3076062 | 19920921 | 19920944 | 14 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | CCATCTCCCCTCCAGTAAAAAGG | OR4K5 | ENSG00000176281 | 0.27910321510129515 | [4,4] | [4,3] | 5 | hSpCas9 | positive selection | 3076063 | 19920801 | 19920824 | 14 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | GACAAATGTCAACAAAGGAAAGG | OR4K5 | ENSG00000176281 | -0.33175598395456507 | [3,3] | [3,0] | -5 | hSpCas9 | positive selection | 3076064 | 19920610 | 19920633 | 14 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | GGATAAGTCCAATTCTTCAGTGG | OR4K5 | ENSG00000176281 | 0.1600652281767588 | [3,3] | [2,2] | 3 | hSpCas9 | positive selection | 3076065 | 19921017 | 19921040 | | + | 24336571 | A375 | resistance to PLX after 7 days | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | 0.10952440327450796 | [20,23] | [22,24] | 3 | hSpCas9 | positive selection | 3132908 | 19920939 | 19920962 | | + | 24336571 | A375 | resistance to PLX after 7 days | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | -0.47692804784319587 | [8,13] | [7,7] | -9 | hSpCas9 | positive selection | 3132909 | 19921017 | 19921040 | | + | 24336571 | A375 | resistance to PLX after 14 days | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | 0.329644729665595 | [18,27] | [13,12] | 3 | hSpCas9 | positive selection | 3190701 | 19920939 | 19920962 | | + | 24336571 | A375 | resistance to PLX after 14 days | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | -0.24429152209477528 | [7,9] | [2,2] | -3 | hSpCas9 | positive selection | 3190702 | 19921017 | 19921040 | | + | 24336571 | A375 | viability after 7 days | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | 0.5718606587984735 | [15] | [20,23] | 8 | hSpCas9 | negative selection | 3248494 | 19920939 | 19920962 | | + | 24336571 | A375 | viability after 7 days | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.6658613955512523 | [6] | [8,13] | 8 | hSpCas9 | negative selection | 3248495 | 19921017 | 19921040 | | + | 24336571 | A375 | viability after 14 days | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | 0.635211381529961 | [15] | [18,27] | 7 | hSpCas9 | negative selection | 3306287 | 19920939 | 19920962 | | + | 24336571 | A375 | viability after 14 days | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.3516794901008871 | [6] | [7,9] | 4 | hSpCas9 | negative selection | 3306288 | 19920992 | 19921015 | 14 | - | 27383988 | 293T | resistance to West Nile virus (flavivirus) | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | 0.8479352753081334 | [84,84] | [0,0] | 4 | hSpCas9 | positive selection | 3383586 | 19921017 | 19921040 | 14 | + | 27383988 | 293T | resistance to West Nile virus (flavivirus) | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.5692222758450799 | [226,226] | [0,0] | -4 | hSpCas9 | positive selection | 3383587 | 19921155 | 19921178 | 14 | + | 27383988 | 293T | resistance to West Nile virus (flavivirus) | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | -1.2184072195205626 | [355,355] | [0,0] | -7 | hSpCas9 | positive selection | 3383588 | 19920991 | 19921014 | 14 | - | 26780180 | HT29 | viability (Avana library 4 designs) | ATGATGACCACATAGTATAAGGG | OR4K5 | ENSG00000176281 | 0.810872031223745 | [] | [] | 3 | hSpCas9 | negative selection | 3446182 | 19920921 | 19920944 | 14 | - | 26780180 | HT29 | viability (Avana library 4 designs) | CCATCTCCCCTCCAGTAAAAAGG | OR4K5 | ENSG00000176281 | 0.0682796809397659 | [] | [] | 0 | hSpCas9 | negative selection | 3446183 | 19920801 | 19920824 | 14 | - | 26780180 | HT29 | viability (Avana library 4 designs) | GACAAATGTCAACAAAGGAAAGG | OR4K5 | ENSG00000176281 | -0.29103983962661 | [] | [] | -5 | hSpCas9 | negative selection | 3446184 | 19920609 | 19920632 | 14 | + | 26780180 | HT29 | viability (Avana library 4 designs) | GGATAAGTCCAATTCTTCAGTGG | OR4K5 | ENSG00000176281 | 1.3027577350604 | [] | [] | 5 | hSpCas9 | negative selection | 3446185 | 19920609 | 19920632 | 14 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GGATAAGTCCAATTCTTCAGTGG | OR4K5 | ENSG00000176281 | 0.81446394670655 | [] | [] | 1 | hSpCas9 | negative selection | 3539376 | 19920991 | 19921014 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | ATGATGACCACATAGTATAAGGG | OR4K5 | ENSG00000176281 | -10.8354523373024 | [] | [] | -8 | hSpCas9 | negative selection | 3539377 | 19920921 | 19920944 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | CCATCTCCCCTCCAGTAAAAAGG | OR4K5 | ENSG00000176281 | 0.770822971471454 | [] | [] | 1 | hSpCas9 | negative selection | 3539378 | 19920801 | 19920824 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GACAAATGTCAACAAAGGAAAGG | OR4K5 | ENSG00000176281 | -4.25230117943258 | [] | [] | -5 | hSpCas9 | negative selection | 3539379 | 19920778 | 19920801 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | TTTCCCAAGAGAAAGTACATAGG | OR4K5 | ENSG00000176281 | -5.22761706010311 | [] | [] | -5 | hSpCas9 | negative selection | 3539380 | 19920871 | 19920894 | 14 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | CACGAGACCATATCTTTCAGTGG | OR4K5 | ENSG00000176281 | -1.40574154274061 | [] | [] | -2 | hSpCas9 | negative selection | 3539381 | 19920609 | 19920632 | 14 | + | 26780180 | A375 | viability (Avana lentiGuide) | GGATAAGTCCAATTCTTCAGTGG | OR4K5 | ENSG00000176281 | -9.06252088566258 | [] | [] | -9 | hSpCas9 | negative selection | 3648035 | 19920991 | 19921014 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | ATGATGACCACATAGTATAAGGG | OR4K5 | ENSG00000176281 | -5.46357270209549 | [] | [] | -8 | hSpCas9 | negative selection | 3648036 | 19920921 | 19920944 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | CCATCTCCCCTCCAGTAAAAAGG | OR4K5 | ENSG00000176281 | -8.15034669965053 | [] | [] | -9 | hSpCas9 | negative selection | 3648037 | 19920801 | 19920824 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | GACAAATGTCAACAAAGGAAAGG | OR4K5 | ENSG00000176281 | -5.04520658297328 | [] | [] | -8 | hSpCas9 | negative selection | 3648038 | 19920778 | 19920801 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | TTTCCCAAGAGAAAGTACATAGG | OR4K5 | ENSG00000176281 | 3.44406600508332 | [] | [] | 3 | hSpCas9 | negative selection | 3648039 | 19920871 | 19920894 | 14 | + | 26780180 | A375 | viability (Avana lentiGuide) | CACGAGACCATATCTTTCAGTGG | OR4K5 | ENSG00000176281 | -6.07813584293187 | [] | [] | -8 | hSpCas9 | negative selection | 3648040 | 19920609 | 19920632 | 14 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GGATAAGTCCAATTCTTCAGTGG | OR4K5 | ENSG00000176281 | -0.14013111797791025 | [5] | [5,4] | -2 | hSpCas9 | positive selection | 3756694 | 19920991 | 19921014 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | ATGATGACCACATAGTATAAGGG | OR4K5 | ENSG00000176281 | -0.7258211417559105 | [9] | [6,3] | -8 | hSpCas9 | positive selection | 3756695 | 19920921 | 19920944 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | CCATCTCCCCTCCAGTAAAAAGG | OR4K5 | ENSG00000176281 | -0.03201132418376568 | [5] | [5,4] | 0 | hSpCas9 | positive selection | 3756696 | 19920801 | 19920824 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GACAAATGTCAACAAAGGAAAGG | OR4K5 | ENSG00000176281 | -0.2778876243418244 | [5] | [5,4] | -4 | hSpCas9 | positive selection | 3756697 | 19920778 | 19920801 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | TTTCCCAAGAGAAAGTACATAGG | OR4K5 | ENSG00000176281 | -0.4367868107032965 | [7] | [5,3] | -6 | hSpCas9 | positive selection | 3756698 | 19920871 | 19920894 | 14 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | CACGAGACCATATCTTTCAGTGG | OR4K5 | ENSG00000176281 | -0.08810752037865821 | [5] | [5,3] | -1 | hSpCas9 | positive selection | 3756699 | 19920609 | 19920632 | 14 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GGATAAGTCCAATTCTTCAGTGG | OR4K5 | ENSG00000176281 | 0.0880696023604717 | [5] | [3,5] | 2 | hSpCas9 | positive selection | 3865301 | 19920991 | 19921014 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | ATGATGACCACATAGTATAAGGG | OR4K5 | ENSG00000176281 | 0.24940914069078424 | [6] | [6,6] | 6 | hSpCas9 | positive selection | 3865302 | 19920921 | 19920944 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | CCATCTCCCCTCCAGTAAAAAGG | OR4K5 | ENSG00000176281 | 0.40608677440493457 | [5] | [7,6] | 9 | hSpCas9 | positive selection | 3865303 | 19920801 | 19920824 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GACAAATGTCAACAAAGGAAAGG | OR4K5 | ENSG00000176281 | 0.4383142857210878 | [5] | [5,6] | 9 | hSpCas9 | positive selection | 3865304 | 19920778 | 19920801 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | TTTCCCAAGAGAAAGTACATAGG | OR4K5 | ENSG00000176281 | 0.19374507244601294 | [5] | [5,6] | 5 | hSpCas9 | positive selection | 3865305 | 19920871 | 19920894 | 14 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | CACGAGACCATATCTTTCAGTGG | OR4K5 | ENSG00000176281 | 0.20621584124263392 | [5] | [5,5] | 5 | hSpCas9 | positive selection | 3865306 | 19921155 | 19921178 | 14 | + | 26780180 | A375 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.56556295218513 | [] | [] | 1 | hSpCas9 | negative selection | 3976228 | 19920984 | 19921007 | 14 | + | 26780180 | A375 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.123398893663741 | [] | [] | 0 | hSpCas9 | negative selection | 3976229 | 19920992 | 19921015 | 14 | - | 26780180 | A375 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | 0.887474058194766 | [] | [] | 4 | hSpCas9 | negative selection | 3976230 | 19921017 | 19921040 | 14 | + | 26780180 | A375 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | 0.671856624025767 | [] | [] | 2 | hSpCas9 | negative selection | 3976231 | 19920939 | 19920962 | 14 | + | 26780180 | A375 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.571810337779494 | [] | [] | 1 | hSpCas9 | negative selection | 3976232 | 19921481 | 19921504 | 14 | + | 26780180 | A375 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.816056815127375 | [] | [] | 3 | hSpCas9 | negative selection | 3976233 | 19921155 | 19921178 | 14 | + | 26780180 | HT29 | viability (GeCKOv2 library) | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.364835092619104 | [] | [] | 1 | hSpCas9 | negative selection | 4084194 | 19920984 | 19921007 | 14 | + | 26780180 | HT29 | viability (GeCKOv2 library) | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.444885800422687 | [] | [] | 1 | hSpCas9 | negative selection | 4084195 | 19920992 | 19921015 | 14 | - | 26780180 | HT29 | viability (GeCKOv2 library) | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | 1.4807097081993 | [] | [] | 7 | hSpCas9 | negative selection | 4084196 | 19921017 | 19921040 | 14 | + | 26780180 | HT29 | viability (GeCKOv2 library) | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | 0.341108323954958 | [] | [] | 0 | hSpCas9 | negative selection | 4084197 | 19920939 | 19920962 | 14 | + | 26780180 | HT29 | viability (GeCKOv2 library) | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.585129955466794 | [] | [] | 2 | hSpCas9 | negative selection | 4084198 | 19921481 | 19921504 | 14 | + | 26780180 | HT29 | viability (GeCKOv2 library) | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.799494642762638 | [] | [] | 3 | hSpCas9 | negative selection | 4084199 | 19921017 | 19921040 | 14 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | 0.1851280487033903 | [4] | [2,3] | 5 | hSpCas9 | positive selection | 4157714 | 19920939 | 19920962 | 14 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | -0.29587278054286625 | [3] | [1,1] | -6 | hSpCas9 | positive selection | 4157715 | 19921017 | 19921040 | 14 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiGuide) | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.8823251618915464 | [3] | [0,0,0,0] | -9 | hSpCas9 | positive selection | 4221736 | 19920939 | 19920962 | 14 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiGuide) | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.28718575935598956 | [2] | [3,2,0,0] | 2 | hSpCas9 | positive selection | 4221737 | 19920939 | 19920962 | 14 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.5388041490699436 | [2] | [2,2] | 9 | hSpCas9 | positive selection | 4287684 | 19921481 | 19921504 | 14 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.11208645220563451 | [1] | [1,0] | 2 | hSpCas9 | positive selection | 4287685 | 19920984 | 19921007 | 14 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.755778469129314 | [2] | [4,4] | 9 | hSpCas9 | positive selection | 4287686 | 19920992 | 19921015 | 14 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | -0.4469716683509066 | [2] | [1,0] | -7 | hSpCas9 | positive selection | 4351940 | 19921017 | 19921040 | 14 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | 0.14871526608629945 | [3] | [3,2] | 3 | hSpCas9 | positive selection | 4351941 | 19921155 | 19921178 | 14 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.03195928948358526 | [3] | [3,2] | 0 | hSpCas9 | positive selection | 4351942 | 19920609 | 19920632 | 14 | + | 27661255 | K562 | viability | GGATAAGTCCAATTCTTCAGTGG | OR4K5 | ENSG00000176281 | 0.008867489744947443 | [1725,1866] | [1585,1318] | 0 | dCas9-KRAB | negative selection | 5499016 | 19920939 | 19920962 | 14 | + | 27260156 | BXPC3 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.48452850941511305 | [212] | [330,186,367,371] | 8 | hSpCas9 | negative selection | 5560144 | 19921481 | 19921504 | 14 | + | 27260156 | BXPC3 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | -0.30073533265658847 | [78] | [22,84,80,84] | -6 | hSpCas9 | negative selection | 5560145 | 19920984 | 19921007 | 14 | + | 27260156 | BXPC3 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.05079138135609107 | [429] | [412,379,441,658] | 1 | hSpCas9 | negative selection | 5560146 | 19920992 | 19921015 | 14 | - | 27260156 | BXPC3 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | -0.13114000006465587 | [232] | [160,166,288,290] | -3 | hSpCas9 | negative selection | 5624400 | 19921017 | 19921040 | 14 | + | 27260156 | BXPC3 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.10243422773219868 | [785] | [726,762,645,944] | -2 | hSpCas9 | negative selection | 5624401 | 19921155 | 19921178 | 14 | + | 27260156 | BXPC3 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.0031432174975033478 | [806] | [792,785,920,892] | 0 | hSpCas9 | negative selection | 5624402 | 19920939 | 19920962 | 14 | + | 27260156 | A673 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.5202170490499762 | [212] | [378,316,446,322] | 9 | hSpCas9 | negative selection | 5681395 | 19921481 | 19921504 | 14 | + | 27260156 | A673 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.291322223765738 | [78] | [78,167,104,105] | 6 | hSpCas9 | negative selection | 5681396 | 19920984 | 19921007 | 14 | + | 27260156 | A673 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.07689248226771639 | [429] | [619,555,426,585] | 1 | hSpCas9 | negative selection | 5681397 | 19920992 | 19921015 | 14 | - | 27260156 | A673 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | -0.4779379809574149 | [232] | [196,176,213,215] | -8 | hSpCas9 | negative selection | 5745651 | 19921017 | 19921040 | 14 | + | 27260156 | A673 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.0943525480409847 | [785] | [1049,870,881,742] | -2 | hSpCas9 | negative selection | 5745652 | 19921155 | 19921178 | 14 | + | 27260156 | A673 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | -0.07501949705642852 | [806] | [1000,851,782,1061] | -2 | hSpCas9 | negative selection | 5745653 | 19920939 | 19920962 | 14 | + | 27260156 | A375 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.6781483674405537 | [212] | [424,525,483,197] | 8 | hSpCas9 | negative selection | 5802646 | 19921481 | 19921504 | 14 | + | 27260156 | A375 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.29046740186635756 | [78] | [76,94,225,56] | 4 | hSpCas9 | negative selection | 5802647 | 19920984 | 19921007 | 14 | + | 27260156 | A375 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.3428841519845987 | [429] | [664,665,593,625] | 5 | hSpCas9 | negative selection | 5802648 | 19920992 | 19921015 | 14 | - | 27260156 | A375 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | -0.3290048402670567 | [232] | [292,152,282,137] | -5 | hSpCas9 | negative selection | 5866902 | 19921017 | 19921040 | 14 | + | 27260156 | A375 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.10458543101750173 | [785] | [932,850,873,764] | -1 | hSpCas9 | negative selection | 5866903 | 19921155 | 19921178 | 14 | + | 27260156 | A375 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.4733898317358399 | [806] | [1305,1649,1142,1191] | 7 | hSpCas9 | negative selection | 5866904 | 19920939 | 19920962 | 14 | + | 27260156 | COLO741 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.28143514486077204 | [212] | [388,298,309] | 6 | hSpCas9 | negative selection | 5923897 | 19921481 | 19921504 | 14 | + | 27260156 | COLO741 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | -0.11230009689642184 | [78] | [119,52,107] | -2 | hSpCas9 | negative selection | 5923898 | 19920984 | 19921007 | 14 | + | 27260156 | COLO741 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.24814663280322177 | [429] | [793,690,494] | 5 | hSpCas9 | negative selection | 5923899 | 19920992 | 19921015 | 14 | - | 27260156 | COLO741 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | -0.33568408970278973 | [232] | [336,148,229] | -6 | hSpCas9 | negative selection | 5988153 | 19921017 | 19921040 | 14 | + | 27260156 | COLO741 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.14972619593402847 | [785] | [846,956,904] | -3 | hSpCas9 | negative selection | 5988154 | 19921155 | 19921178 | 14 | + | 27260156 | COLO741 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | -0.06719560801884361 | [806] | [1110,867,981] | -1 | hSpCas9 | negative selection | 5988155 | 19920939 | 19920962 | 14 | + | 27260156 | CAL120 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.638288035258665 | [212] | [717,239,326] | 8 | hSpCas9 | negative selection | 6045148 | 19921481 | 19921504 | 14 | + | 27260156 | CAL120 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.6005304894609389 | [78] | [148,142,154] | 8 | hSpCas9 | negative selection | 6045149 | 19920984 | 19921007 | 14 | + | 27260156 | CAL120 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.10086408954576706 | [429] | [689,600,449] | 1 | hSpCas9 | negative selection | 6045150 | 19920992 | 19921015 | 14 | - | 27260156 | CAL120 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | 0.07283244758043561 | [232] | [224,388,288] | 1 | hSpCas9 | negative selection | 6109404 | 19921017 | 19921040 | 14 | + | 27260156 | CAL120 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.17186865872580415 | [785] | [1079,954,605] | -3 | hSpCas9 | negative selection | 6109405 | 19921155 | 19921178 | 14 | + | 27260156 | CAL120 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.10214333697734901 | [806] | [1732,922,682] | 1 | hSpCas9 | negative selection | 6109406 | 19920939 | 19920962 | 14 | + | 27260156 | CADOES1 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.9286895713204846 | [212] | [544,297,333,328] | 9 | hSpCas9 | negative selection | 6166399 | 19921481 | 19921504 | 14 | + | 27260156 | CADOES1 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.3558570017203606 | [78] | [78,68,59,170] | 6 | hSpCas9 | negative selection | 6166400 | 19920984 | 19921007 | 14 | + | 27260156 | CADOES1 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.3824773545526522 | [429] | [398,717,474,492] | 6 | hSpCas9 | negative selection | 6166401 | 19920992 | 19921015 | 14 | - | 27260156 | CADOES1 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | 0.12978161589834525 | [232] | [198,253,271,222] | 2 | hSpCas9 | negative selection | 6230655 | 19921017 | 19921040 | 14 | + | 27260156 | CADOES1 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.19594382540827882 | [785] | [598,606,778,564] | -3 | hSpCas9 | negative selection | 6230656 | 19921155 | 19921178 | 14 | + | 27260156 | CADOES1 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.281384761149328 | [806] | [855,1121,743,927] | 5 | hSpCas9 | negative selection | 6230657 | 19920939 | 19920962 | 14 | + | 27260156 | EWS502 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.4127356567566539 | [212] | [181,281,458,293] | 7 | hSpCas9 | negative selection | 6287650 | 19921481 | 19921504 | 14 | + | 27260156 | EWS502 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | -0.10620994419018759 | [78] | [49,49,153,60] | -2 | hSpCas9 | negative selection | 6287651 | 19920984 | 19921007 | 14 | + | 27260156 | EWS502 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | -0.11480941089270033 | [429] | [292,404,646,349] | -2 | hSpCas9 | negative selection | 6287652 | 19920992 | 19921015 | 14 | - | 27260156 | EWS502 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | -0.22444820787336583 | [232] | [254,229,237,107] | -4 | hSpCas9 | negative selection | 6351906 | 19921017 | 19921040 | 14 | + | 27260156 | EWS502 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.4878800627081981 | [785] | [621,520,480,757] | -7 | hSpCas9 | negative selection | 6351907 | 19921155 | 19921178 | 14 | + | 27260156 | EWS502 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.02248996087648547 | [806] | [708,707,845,1259] | 0 | hSpCas9 | negative selection | 6351908 | 19920939 | 19920962 | 14 | + | 27260156 | EW8 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.44293800624475443 | [212] | [182,294,243,208] | 7 | hSpCas9 | negative selection | 6408901 | 19921481 | 19921504 | 14 | + | 27260156 | EW8 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | -0.20954927839611992 | [78] | [33,60,30,96] | -4 | hSpCas9 | negative selection | 6408902 | 19920984 | 19921007 | 14 | + | 27260156 | EW8 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.19015865982285202 | [429] | [485,433,309,383] | 3 | hSpCas9 | negative selection | 6408903 | 19920992 | 19921015 | 14 | - | 27260156 | EW8 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | 0.01447611262750026 | [232] | [331,90,145,215] | 0 | hSpCas9 | negative selection | 6473157 | 19921017 | 19921040 | 14 | + | 27260156 | EW8 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.2831918468849111 | [785] | [639,540,382,564] | -5 | hSpCas9 | negative selection | 6473158 | 19921155 | 19921178 | 14 | + | 27260156 | EW8 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | -0.07544490150240346 | [806] | [863,490,580,577] | -1 | hSpCas9 | negative selection | 6473159 | 19920939 | 19920962 | 14 | + | 27260156 | CORL105 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.31133508581354563 | [212] | [277,225,467,290] | 6 | hSpCas9 | negative selection | 6530152 | 19921481 | 19921504 | 14 | + | 27260156 | CORL105 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.19816541922618391 | [78] | [102,120,105,93] | 3 | hSpCas9 | negative selection | 6530153 | 19920984 | 19921007 | 14 | + | 27260156 | CORL105 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | -0.010574078462165959 | [429] | [517,483,501,495] | 0 | hSpCas9 | negative selection | 6530154 | 19920992 | 19921015 | 14 | - | 27260156 | CORL105 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | -0.3262561096938754 | [232] | [232,216,218,201] | -5 | hSpCas9 | negative selection | 6594408 | 19921017 | 19921040 | 14 | + | 27260156 | CORL105 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.18337918666174102 | [785] | [922,696,865,769] | -3 | hSpCas9 | negative selection | 6594409 | 19921155 | 19921178 | 14 | + | 27260156 | CORL105 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.24781654601334624 | [806] | [872,1190,1420,1038] | 4 | hSpCas9 | negative selection | 6594410 | 19920939 | 19920962 | 14 | + | 27260156 | HS294T | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | -0.1455733438368807 | [212] | [61,84,73,77] | -2 | hSpCas9 | negative selection | 6651403 | 19921481 | 19921504 | 14 | + | 27260156 | HS294T | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.2752119701286726 | [78] | [22,39,48,36] | 4 | hSpCas9 | negative selection | 6651404 | 19920984 | 19921007 | 14 | + | 27260156 | HS294T | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.2615348736066772 | [429] | [140,165,218,292] | 3 | hSpCas9 | negative selection | 6651405 | 19920992 | 19921015 | 14 | - | 27260156 | HS294T | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | 0.7580656006920885 | [232] | [224,92,127,158] | 8 | hSpCas9 | negative selection | 6715659 | 19921017 | 19921040 | 14 | + | 27260156 | HS294T | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.3651238366378184 | [785] | [177,163,313,306] | -5 | hSpCas9 | negative selection | 6715660 | 19921155 | 19921178 | 14 | + | 27260156 | HS294T | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.15119404833435546 | [806] | [271,298,334,515] | 2 | hSpCas9 | negative selection | 6715661 | 19920939 | 19920962 | 14 | + | 27260156 | HCC44 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.31244685708205633 | [212] | [215,288,322,361] | 5 | hSpCas9 | negative selection | 6772654 | 19921481 | 19921504 | 14 | + | 27260156 | HCC44 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | -0.8789412383256732 | [78] | [14,38,28,103] | -8 | hSpCas9 | negative selection | 6772655 | 19920984 | 19921007 | 14 | + | 27260156 | HCC44 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.09846359757718245 | [429] | [547,537,635,380] | 1 | hSpCas9 | negative selection | 6772656 | 19920992 | 19921015 | 14 | - | 27260156 | HCC44 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | -0.1370044939795665 | [232] | [283,163,394,157] | -2 | hSpCas9 | negative selection | 6836910 | 19921017 | 19921040 | 14 | + | 27260156 | HCC44 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | 0.1430232509097462 | [785] | [1342,969,1189,501] | 2 | hSpCas9 | negative selection | 6836911 | 19921155 | 19921178 | 14 | + | 27260156 | HCC44 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.033307847431083726 | [806] | [1037,725,907,1085] | 0 | hSpCas9 | negative selection | 6836912 | 19920939 | 19920962 | 14 | + | 27260156 | G402 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | -0.08605953908578545 | [212] | [276,261,176,266] | -1 | hSpCas9 | negative selection | 6893905 | 19921481 | 19921504 | 14 | + | 27260156 | G402 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | -0.5148174976292861 | [78] | [80,87,83,21] | -6 | hSpCas9 | negative selection | 6893906 | 19920984 | 19921007 | 14 | + | 27260156 | G402 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.289729122111667 | [429] | [808,652,782,356] | 3 | hSpCas9 | negative selection | 6893907 | 19920992 | 19921015 | 14 | - | 27260156 | G402 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | 0.07639819456486152 | [232] | [305,444,235,223] | 1 | hSpCas9 | negative selection | 6958161 | 19921017 | 19921040 | 14 | + | 27260156 | G402 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.17957945800276987 | [785] | [856,632,928,948] | -2 | hSpCas9 | negative selection | 6958162 | 19921155 | 19921178 | 14 | + | 27260156 | G402 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.35517520446293294 | [806] | [1875,572,1235,1390] | 4 | hSpCas9 | negative selection | 6958163 | 19920939 | 19920962 | 14 | + | 27260156 | L33 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.16335312917940847 | [212] | [215,109,129,262] | 3 | hSpCas9 | negative selection | 7015156 | 19921481 | 19921504 | 14 | + | 27260156 | L33 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.6025700719944733 | [78] | [117,46,63,144] | 9 | hSpCas9 | negative selection | 7015157 | 19920984 | 19921007 | 14 | + | 27260156 | L33 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.41344926081742606 | [429] | [777,185,327,531] | 8 | hSpCas9 | negative selection | 7015158 | 19920992 | 19921015 | 14 | - | 27260156 | L33 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | 0.007150801816794949 | [232] | [169,70,202,271] | 0 | hSpCas9 | negative selection | 7079412 | 19921017 | 19921040 | 14 | + | 27260156 | L33 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.01487460948410746 | [785] | [834,261,467,889] | 0 | hSpCas9 | negative selection | 7079413 | 19921155 | 19921178 | 14 | + | 27260156 | L33 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | -0.21945849670271989 | [806] | [832,250,388,703] | -5 | hSpCas9 | negative selection | 7079414 | 19920939 | 19920962 | 14 | + | 27260156 | K562 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.3997258908694675 | [212] | [250,286,243,219] | 5 | hSpCas9 | negative selection | 7136407 | 19921481 | 19921504 | 14 | + | 27260156 | K562 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.835717145224085 | [78] | [42,275,64,117] | 9 | hSpCas9 | negative selection | 7136408 | 19920984 | 19921007 | 14 | + | 27260156 | K562 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | -0.02275803102321683 | [429] | [570,213,362,361] | 0 | hSpCas9 | negative selection | 7136409 | 19920992 | 19921015 | 14 | - | 27260156 | K562 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | 0.5126066699935852 | [232] | [450,338,327,98] | 6 | hSpCas9 | negative selection | 7200663 | 19921017 | 19921040 | 14 | + | 27260156 | K562 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.10788884585250336 | [785] | [743,601,722,535] | -1 | hSpCas9 | negative selection | 7200664 | 19921155 | 19921178 | 14 | + | 27260156 | K562 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.29607490386160096 | [806] | [1077,947,945,594] | 4 | hSpCas9 | negative selection | 7200665 | 19920939 | 19920962 | 14 | + | 27260156 | HT29 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.22668406830380883 | [212] | [239,407,272,293] | 4 | hSpCas9 | negative selection | 7257658 | 19921481 | 19921504 | 14 | + | 27260156 | HT29 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.4740950909989685 | [78] | [146,159,140,92] | 8 | hSpCas9 | negative selection | 7257659 | 19920984 | 19921007 | 14 | + | 27260156 | HT29 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.350914228939343 | [429] | [831,857,505,513] | 7 | hSpCas9 | negative selection | 7257660 | 19920992 | 19921015 | 14 | - | 27260156 | HT29 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | 0.09479033439050066 | [232] | [237,316,274,365] | 1 | hSpCas9 | negative selection | 7321914 | 19921017 | 19921040 | 14 | + | 27260156 | HT29 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.16843813426260623 | [785] | [1035,765,824,782] | -3 | hSpCas9 | negative selection | 7321915 | 19921155 | 19921178 | 14 | + | 27260156 | HT29 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.1199733626261168 | [806] | [1032,1245,1216,805] | 2 | hSpCas9 | negative selection | 7321916 | 19920939 | 19920962 | 14 | + | 27260156 | MHHES1 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.7598271524207136 | [212] | [465,526,311,343] | 9 | hSpCas9 | negative selection | 7378909 | 19921481 | 19921504 | 14 | + | 27260156 | MHHES1 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.5371911951210215 | [78] | [202,107,54,148] | 8 | hSpCas9 | negative selection | 7378910 | 19920984 | 19921007 | 14 | + | 27260156 | MHHES1 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.5330013323505325 | [429] | [1063,552,520,680] | 8 | hSpCas9 | negative selection | 7378911 | 19920992 | 19921015 | 14 | - | 27260156 | MHHES1 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | 0.3554133195474176 | [232] | [412,325,404,225] | 6 | hSpCas9 | negative selection | 7443165 | 19921017 | 19921040 | 14 | + | 27260156 | MHHES1 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.0013490835788433353 | [785] | [1032,998,608,899] | 0 | hSpCas9 | negative selection | 7443166 | 19921155 | 19921178 | 14 | + | 27260156 | MHHES1 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.20665740665912324 | [806] | [1123,1243,1225,691] | 4 | hSpCas9 | negative selection | 7443167 | 19920939 | 19920962 | 14 | + | 27260156 | MEWO | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.5162671444490898 | [212] | [387,269,216] | 9 | hSpCas9 | negative selection | 7500160 | 19921481 | 19921504 | 14 | + | 27260156 | MEWO | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | -0.011672917637021385 | [78] | [42,83,86] | 0 | hSpCas9 | negative selection | 7500161 | 19920984 | 19921007 | 14 | + | 27260156 | MEWO | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.4718632154561855 | [429] | [588,497,592] | 8 | hSpCas9 | negative selection | 7500162 | 19920992 | 19921015 | 14 | - | 27260156 | MEWO | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | -0.2553969754530805 | [232] | [239,168,149] | -5 | hSpCas9 | negative selection | 7564416 | 19921017 | 19921040 | 14 | + | 27260156 | MEWO | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.029579443905310865 | [785] | [835,620,726] | 0 | hSpCas9 | negative selection | 7564417 | 19921155 | 19921178 | 14 | + | 27260156 | MEWO | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | -0.1572898794970915 | [806] | [717,641,678] | -3 | hSpCas9 | negative selection | 7564418 | 19920939 | 19920962 | 14 | + | 27260156 | LNCAPCLONEFGC | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.29192539578951426 | [212] | [197,207,233,306] | 4 | hSpCas9 | negative selection | 7621411 | 19921481 | 19921504 | 14 | + | 27260156 | LNCAPCLONEFGC | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.09094209502979567 | [78] | [109,47,75,71] | 1 | hSpCas9 | negative selection | 7621412 | 19920984 | 19921007 | 14 | + | 27260156 | LNCAPCLONEFGC | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.414980847643486 | [429] | [708,421,419,513] | 6 | hSpCas9 | negative selection | 7621413 | 19920992 | 19921015 | 14 | - | 27260156 | LNCAPCLONEFGC | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | -0.36001472408951685 | [232] | [214,134,159,147] | -5 | hSpCas9 | negative selection | 7685667 | 19921017 | 19921040 | 14 | + | 27260156 | LNCAPCLONEFGC | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.35928842998963306 | [785] | [435,442,773,608] | -5 | hSpCas9 | negative selection | 7685668 | 19921155 | 19921178 | 14 | + | 27260156 | LNCAPCLONEFGC | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.16905558773320162 | [806] | [1056,516,931,812] | 2 | hSpCas9 | negative selection | 7685669 | 19920939 | 19920962 | 14 | + | 27260156 | PANC0327 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.5158169146532927 | [212] | [373,274,260,179] | 7 | hSpCas9 | negative selection | 7742662 | 19921481 | 19921504 | 14 | + | 27260156 | PANC0327 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.7410531810530352 | [78] | [186,37,87,171] | 9 | hSpCas9 | negative selection | 7742663 | 19920984 | 19921007 | 14 | + | 27260156 | PANC0327 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.4954254497367635 | [429] | [558,526,568,501] | 7 | hSpCas9 | negative selection | 7742664 | 19920992 | 19921015 | 14 | - | 27260156 | PANC0327 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | 0.05840753967471435 | [232] | [211,374,94,158] | 0 | hSpCas9 | negative selection | 7806918 | 19921017 | 19921040 | 14 | + | 27260156 | PANC0327 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | 0.09578124933878607 | [785] | [864,797,538,784] | 1 | hSpCas9 | negative selection | 7806919 | 19921155 | 19921178 | 14 | + | 27260156 | PANC0327 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.246582479215664 | [806] | [1245,592,682,944] | 3 | hSpCas9 | negative selection | 7806920 | 19920939 | 19920962 | 14 | + | 27260156 | NCIH2009 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.26885779288030853 | [212] | [596,203,323] | 3 | hSpCas9 | negative selection | 7863913 | 19921481 | 19921504 | 14 | + | 27260156 | NCIH2009 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.8110336852116131 | [78] | [283,164,149] | 9 | hSpCas9 | negative selection | 7863914 | 19920984 | 19921007 | 14 | + | 27260156 | NCIH2009 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.19403206981490262 | [429] | [666,555,835] | 2 | hSpCas9 | negative selection | 7863915 | 19920992 | 19921015 | 14 | - | 27260156 | NCIH2009 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | -0.8854292212135162 | [232] | [199,234,96] | -8 | hSpCas9 | negative selection | 7928169 | 19921017 | 19921040 | 14 | + | 27260156 | NCIH2009 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.19265454689067885 | [785] | [1387,985,590] | -3 | hSpCas9 | negative selection | 7928170 | 19921155 | 19921178 | 14 | + | 27260156 | NCIH2009 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.2460752235078839 | [806] | [1927,1176,1023] | 3 | hSpCas9 | negative selection | 7928171 | 19920939 | 19920962 | 14 | + | 27260156 | NCIH1373 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.14091756030540958 | [212] | [330,253,338,33] | 1 | hSpCas9 | negative selection | 7985164 | 19921481 | 19921504 | 14 | + | 27260156 | NCIH1373 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | -0.019632738888490042 | [78] | [98,80,69,26] | 0 | hSpCas9 | negative selection | 7985165 | 19920984 | 19921007 | 14 | + | 27260156 | NCIH1373 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.22282854850745953 | [429] | [382,591,422,219] | 2 | hSpCas9 | negative selection | 7985166 | 19920992 | 19921015 | 14 | - | 27260156 | NCIH1373 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | -0.5640951410804429 | [232] | [173,106,128,81] | -5 | hSpCas9 | negative selection | 8049420 | 19921017 | 19921040 | 14 | + | 27260156 | NCIH1373 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.5996382890001589 | [785] | [712,414,498,195] | -5 | hSpCas9 | negative selection | 8049421 | 19921155 | 19921178 | 14 | + | 27260156 | NCIH1373 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.21735438529709805 | [806] | [1287,755,1256,251] | 2 | hSpCas9 | negative selection | 8049422 | 19920939 | 19920962 | 14 | + | 27260156 | PATU8902 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.40902302686753556 | [212] | [896,426,160,106] | 4 | hSpCas9 | negative selection | 8106415 | 19921481 | 19921504 | 14 | + | 27260156 | PATU8902 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 1.085371939000311 | [78] | [135,254,359,137] | 9 | hSpCas9 | negative selection | 8106416 | 19920984 | 19921007 | 14 | + | 27260156 | PATU8902 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.21980066065025133 | [429] | [661,978,521,663] | 2 | hSpCas9 | negative selection | 8106417 | 19920992 | 19921015 | 14 | - | 27260156 | PATU8902 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | -0.33003665716137864 | [232] | [401,311,149,183] | -3 | hSpCas9 | negative selection | 8170671 | 19921017 | 19921040 | 14 | + | 27260156 | PATU8902 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.07981873140678675 | [785] | [1339,1157,755,937] | -1 | hSpCas9 | negative selection | 8170672 | 19921155 | 19921178 | 14 | + | 27260156 | PATU8902 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.6684799575193828 | [806] | [2132,1464,1475,2178] | 7 | hSpCas9 | negative selection | 8170673 | 19920939 | 19920962 | 14 | + | 27260156 | PANC1 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.6225692570291003 | [212] | [188,528,207,252] | 8 | hSpCas9 | negative selection | 8227666 | 19921481 | 19921504 | 14 | + | 27260156 | PANC1 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.013484218127727043 | [78] | [111,73,20,65] | 0 | hSpCas9 | negative selection | 8227667 | 19920984 | 19921007 | 14 | + | 27260156 | PANC1 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | -0.12409520668995214 | [429] | [324,445,363,251] | -2 | hSpCas9 | negative selection | 8227668 | 19920992 | 19921015 | 14 | - | 27260156 | PANC1 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | -0.45545613545474817 | [232] | [170,207,81,133] | -6 | hSpCas9 | negative selection | 8291922 | 19921017 | 19921040 | 14 | + | 27260156 | PANC1 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.617396153358597 | [785] | [212,599,468,498] | -7 | hSpCas9 | negative selection | 8291923 | 19921155 | 19921178 | 14 | + | 27260156 | PANC1 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | -0.11221921037954619 | [806] | [718,879,601,434] | -2 | hSpCas9 | negative selection | 8291924 | 19920939 | 19920962 | 14 | + | 27260156 | PANC0813 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.4888464613970861 | [212] | [360,320,510,219] | 7 | hSpCas9 | negative selection | 8348917 | 19921481 | 19921504 | 14 | + | 27260156 | PANC0813 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.1262869947132348 | [78] | [116,28,197,64] | 2 | hSpCas9 | negative selection | 8348918 | 19920984 | 19921007 | 14 | + | 27260156 | PANC0813 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.2990103802369545 | [429] | [621,771,487,602] | 5 | hSpCas9 | negative selection | 8348919 | 19920992 | 19921015 | 14 | - | 27260156 | PANC0813 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | 0.5399700321194013 | [232] | [795,234,300,300] | 8 | hSpCas9 | negative selection | 8413173 | 19921017 | 19921040 | 14 | + | 27260156 | PANC0813 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | 0.31526254585992797 | [785] | [1261,1022,1224,1096] | 5 | hSpCas9 | negative selection | 8413174 | 19921155 | 19921178 | 14 | + | 27260156 | PANC0813 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.5209972649495508 | [806] | [1261,1312,1352,1493] | 8 | hSpCas9 | negative selection | 8413175 | 19920939 | 19920962 | 14 | + | 27260156 | RDES | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.6261943338617653 | [212] | [229,460,312,544] | 8 | hSpCas9 | negative selection | 8470168 | 19921481 | 19921504 | 14 | + | 27260156 | RDES | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.04466119990184003 | [78] | [75,60,86,165] | 0 | hSpCas9 | negative selection | 8470169 | 19920984 | 19921007 | 14 | + | 27260156 | RDES | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.20401842117739283 | [429] | [430,588,607,679] | 3 | hSpCas9 | negative selection | 8470170 | 19920992 | 19921015 | 14 | - | 27260156 | RDES | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | -0.07831784929279495 | [232] | [200,276,151,405] | -1 | hSpCas9 | negative selection | 8534424 | 19921017 | 19921040 | 14 | + | 27260156 | RDES | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.5061299800124999 | [785] | [630,567,663,675] | -7 | hSpCas9 | negative selection | 8534425 | 19921155 | 19921178 | 14 | + | 27260156 | RDES | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.26601665667754204 | [806] | [949,986,1062,1540] | 4 | hSpCas9 | negative selection | 8534426 | 19920939 | 19920962 | 14 | + | 27260156 | PC3 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | -0.6252212181785615 | [212] | [132,121,201,99] | -8 | hSpCas9 | negative selection | 8591419 | 19921481 | 19921504 | 14 | + | 27260156 | PC3 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | -0.14749357742153846 | [78] | [47,83,137,40] | -3 | hSpCas9 | negative selection | 8591420 | 19920984 | 19921007 | 14 | + | 27260156 | PC3 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.246699465099752 | [429] | [393,328,907,562] | 5 | hSpCas9 | negative selection | 8591421 | 19920992 | 19921015 | 14 | - | 27260156 | PC3 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | 0.3521796390920574 | [232] | [155,437,350,288] | 7 | hSpCas9 | negative selection | 8655675 | 19921017 | 19921040 | 14 | + | 27260156 | PC3 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | 0.058052109913625194 | [785] | [595,927,1212,670] | 1 | hSpCas9 | negative selection | 8655676 | 19921155 | 19921178 | 14 | + | 27260156 | PC3 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | -0.2428822403659736 | [806] | [443,599,1149,750] | -5 | hSpCas9 | negative selection | 8655677 | 19920939 | 19920962 | 14 | + | 27260156 | PATU8988T | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.7531016609107236 | [212] | [326,225,292,546] | 9 | hSpCas9 | negative selection | 8712670 | 19921481 | 19921504 | 14 | + | 27260156 | PATU8988T | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | -0.19028351167008406 | [78] | [55,51,79,78] | -3 | hSpCas9 | negative selection | 8712671 | 19920984 | 19921007 | 14 | + | 27260156 | PATU8988T | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.2708536193881329 | [429] | [662,587,279,483] | 4 | hSpCas9 | negative selection | 8712672 | 19920992 | 19921015 | 14 | - | 27260156 | PATU8988T | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | -0.20025865815640986 | [232] | [126,238,180,244] | -3 | hSpCas9 | negative selection | 8776926 | 19921017 | 19921040 | 14 | + | 27260156 | PATU8988T | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.09031682260658203 | [785] | [671,916,567,717] | -1 | hSpCas9 | negative selection | 8776927 | 19921155 | 19921178 | 14 | + | 27260156 | PATU8988T | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.04594179486416394 | [806] | [747,910,848,713] | 0 | hSpCas9 | negative selection | 8776928 | 19920939 | 19920962 | 14 | + | 27260156 | T47D | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.40432523455528546 | [212] | [367,281,309,358] | 8 | hSpCas9 | negative selection | 8833921 | 19921481 | 19921504 | 14 | + | 27260156 | T47D | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | -0.14809399412986846 | [78] | [104,114,34,74] | -3 | hSpCas9 | negative selection | 8833922 | 19920984 | 19921007 | 14 | + | 27260156 | T47D | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.27688253092953796 | [429] | [639,651,525,606] | 6 | hSpCas9 | negative selection | 8833923 | 19920992 | 19921015 | 14 | - | 27260156 | T47D | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | 0.07261724950547965 | [232] | [265,239,302,337] | 1 | hSpCas9 | negative selection | 8898177 | 19921017 | 19921040 | 14 | + | 27260156 | T47D | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.09424278973241862 | [785] | [958,733,839,910] | -2 | hSpCas9 | negative selection | 8898178 | 19921155 | 19921178 | 14 | + | 27260156 | T47D | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | -0.03672182979204841 | [806] | [918,937,855,952] | -1 | hSpCas9 | negative selection | 8898179 | 19920939 | 19920962 | 14 | + | 27260156 | SU8686 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.5064929857821115 | [212] | [250,326,237,397] | 8 | hSpCas9 | negative selection | 8955172 | 19921481 | 19921504 | 14 | + | 27260156 | SU8686 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.16511870492902725 | [78] | [35,111,119,85] | 2 | hSpCas9 | negative selection | 8955173 | 19920984 | 19921007 | 14 | + | 27260156 | SU8686 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.30903592727831763 | [429] | [459,448,416,849] | 5 | hSpCas9 | negative selection | 8955174 | 19920992 | 19921015 | 14 | - | 27260156 | SU8686 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | 0.1349159674077628 | [232] | [180,176,316,377] | 2 | hSpCas9 | negative selection | 9019428 | 19921017 | 19921040 | 14 | + | 27260156 | SU8686 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.1028731745806104 | [785] | [696,682,553,1013] | -2 | hSpCas9 | negative selection | 9019429 | 19921155 | 19921178 | 14 | + | 27260156 | SU8686 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.07926987630439253 | [806] | [725,744,938,1022] | 1 | hSpCas9 | negative selection | 9019430 | 19920939 | 19920962 | 14 | + | 27260156 | SKES1 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.4642917298205501 | [212] | [228,278,377,273] | 8 | hSpCas9 | negative selection | 9076423 | 19921481 | 19921504 | 14 | + | 27260156 | SKES1 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.017473327148705753 | [78] | [43,107,109,56] | 0 | hSpCas9 | negative selection | 9076424 | 19920984 | 19921007 | 14 | + | 27260156 | SKES1 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.3531969605945755 | [429] | [594,686,460,475] | 7 | hSpCas9 | negative selection | 9076425 | 19920992 | 19921015 | 14 | - | 27260156 | SKES1 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | -0.09738608405336735 | [232] | [356,224,164,148] | -2 | hSpCas9 | negative selection | 9140679 | 19921017 | 19921040 | 14 | + | 27260156 | SKES1 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.08752857783733159 | [785] | [844,742,721,658] | -2 | hSpCas9 | negative selection | 9140680 | 19921155 | 19921178 | 14 | + | 27260156 | SKES1 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | -0.05523124858076034 | [806] | [777,732,873,707] | -1 | hSpCas9 | negative selection | 9140681 | 19920939 | 19920962 | 14 | + | 27260156 | TOV112D | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | -0.16327703742045285 | [212] | [159,230,147,228] | -3 | hSpCas9 | negative selection | 9197674 | 19921481 | 19921504 | 14 | + | 27260156 | TOV112D | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.7678731167306299 | [78] | [157,217,117,68] | 9 | hSpCas9 | negative selection | 9197675 | 19920984 | 19921007 | 14 | + | 27260156 | TOV112D | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.046870979599156606 | [429] | [386,380,464,522] | 0 | hSpCas9 | negative selection | 9197676 | 19920992 | 19921015 | 14 | - | 27260156 | TOV112D | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | -0.13633344121785118 | [232] | [263,254,212,133] | -3 | hSpCas9 | negative selection | 9261930 | 19921017 | 19921040 | 14 | + | 27260156 | TOV112D | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.035676145623506295 | [785] | [593,1421,650,555] | 0 | hSpCas9 | negative selection | 9261931 | 19921155 | 19921178 | 14 | + | 27260156 | TOV112D | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.2349152613443396 | [806] | [818,1160,1178,691] | 4 | hSpCas9 | negative selection | 9261932 | 19920939 | 19920962 | 14 | + | 27260156 | TC71 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.6014679007482214 | [212] | [316,428,225,422] | 9 | hSpCas9 | negative selection | 9318925 | 19921481 | 19921504 | 14 | + | 27260156 | TC71 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | -0.38053388698501545 | [78] | [68,68,40,82] | -8 | hSpCas9 | negative selection | 9318926 | 19920984 | 19921007 | 14 | + | 27260156 | TC71 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.1705953403082112 | [429] | [447,601,468,561] | 4 | hSpCas9 | negative selection | 9318927 | 19920992 | 19921015 | 14 | - | 27260156 | TC71 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | 0.14997090178628458 | [232] | [244,234,297,333] | 4 | hSpCas9 | negative selection | 9383181 | 19921017 | 19921040 | 14 | + | 27260156 | TC71 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.11855655754398509 | [785] | [705,779,847,768] | -3 | hSpCas9 | negative selection | 9383182 | 19921155 | 19921178 | 14 | + | 27260156 | TC71 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | -0.023415671211130862 | [806] | [676,971,831,932] | 0 | hSpCas9 | negative selection | 9383183 | 19920939 | 19920962 | 14 | + | 27260156 | TC32 | viability | GATGGTGCTACTTGTTTCGATGG | OR4K5 | ENSG00000176281 | 0.46679921421901294 | [212] | [314,126,373,347] | 7 | hSpCas9 | negative selection | 9440176 | 19921481 | 19921504 | 14 | + | 27260156 | TC32 | viability | GGGATATGAAGGCTGCCGTAAGG | OR4K5 | ENSG00000176281 | 0.06727215805631648 | [78] | [121,24,52,118] | 1 | hSpCas9 | negative selection | 9440177 | 19920984 | 19921007 | 14 | + | 27260156 | TC32 | viability | ATGCAAACCCTTATACTATGTGG | OR4K5 | ENSG00000176281 | 0.35351158711006325 | [429] | [418,466,669,535] | 6 | hSpCas9 | negative selection | 9440178 | 19920992 | 19921015 | 14 | - | 27260156 | TC32 | viability | CATGATGACCACATAGTATAAGG | OR4K5 | ENSG00000176281 | -0.1390043904060494 | [232] | [191,169,248,191] | -2 | hSpCas9 | negative selection | 9504432 | 19921017 | 19921040 | 14 | + | 27260156 | TC32 | viability | CCGAAGGACATGCACTGTCTTGG | OR4K5 | ENSG00000176281 | -0.2057715051201071 | [785] | [543,397,834,901] | -4 | hSpCas9 | negative selection | 9504433 | 19921155 | 19921178 | 14 | + | 27260156 | TC32 | viability | AGTCACCAAACTTGCCTGCCTGG | OR4K5 | ENSG00000176281 | 0.0784649101793018 | [806] | [661,587,1169,904] | 1 | hSpCas9 | negative selection | 9504434 | 19921001 | 19921024 | 14 | + | 27869803 | HPAFII | viability after 27 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | -0.5009902005568333 | [184] | [35,95,NaN] | -4 | hSpCas9 | negative selection | 9550805 | 19921284 | 19921307 | 14 | + | 27869803 | HPAFII | viability after 27 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | 0.991954840690679 | [256] | [133,380,NaN] | 7 | hSpCas9 | negative selection | 9550806 | 19921001 | 19921024 | 14 | + | 27869803 | HPAFII | viability after 15 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | -1.1152056295288446 | [184] | [84,95,NaN] | -8 | hSpCas9 | negative selection | 9633254 | 19921284 | 19921307 | 14 | + | 27869803 | HPAFII | viability after 15 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | 0.3953990775047622 | [256] | [485,286,NaN] | 4 | hSpCas9 | negative selection | 9633255 | 19921001 | 19921024 | 14 | + | 27869803 | ASPC1 | viability after 36 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | -0.15421569006018654 | [254] | [157,77,25] | -2 | hSpCas9 | negative selection | 9715703 | 19921284 | 19921307 | 14 | + | 27869803 | ASPC1 | viability after 36 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | -0.00426524753970442 | [782] | [112,373,300] | 0 | hSpCas9 | negative selection | 9715704 | 19921001 | 19921024 | 14 | + | 27869803 | PATU8988S | viability after 35 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | 0.5197774183605487 | [282] | [125,200,NaN] | 6 | hSpCas9 | negative selection | 9798152 | 19921284 | 19921307 | 14 | + | 27869803 | PATU8988S | viability after 35 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | -0.6339681681296464 | [629] | [165,160,NaN] | -6 | hSpCas9 | negative selection | 9798153 | 19921001 | 19921024 | 14 | + | 27869803 | PATU8988S | viability after 31 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | 0.2868681824426871 | [282] | [83,205,NaN] | 3 | hSpCas9 | negative selection | 9880601 | 19921284 | 19921307 | 14 | + | 27869803 | PATU8988S | viability after 31 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | -0.18152624648376167 | [629] | [162,295,NaN] | -2 | hSpCas9 | negative selection | 9880602 | 19921001 | 19921024 | 14 | + | 27869803 | HPAFII | viability after 35 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | -0.6499300135597306 | [184] | [22,100,NaN] | -4 | hSpCas9 | negative selection | 9963050 | 19921284 | 19921307 | 14 | + | 27869803 | HPAFII | viability after 35 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | 1.3273420562385885 | [256] | [119,558,NaN] | 8 | hSpCas9 | negative selection | 9963051 | 19921001 | 19921024 | 14 | + | 27869803 | HPAFII | viability after 31 days | ATGTGGTCATCATGAGCCGAAGG | OR4K5 | ENSG00000176281 | -0.6867830054178004 | [184] | [30,100,NaN] | -4 | hSpCas9 | negative selection | 10045499 | 19921284 | 19921307 | 14 | + | 27869803 | HPAFII | viability after 31 days | GCTCAAGTCTTCAGCTGCAATGG | OR4K5 | ENSG00000176281 | 1.2244125874268337 | [256] | [113,579,NaN] | 8 | hSpCas9 | negative selection | 10045500 |