Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:5170
• Symbol:PDPK1
• Description:3-phosphoinositide dependent protein kinase 1

DataSource: http://genomecrispr.dkfz.de/#!/results/PDPK1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
2586722	2586745	16	-	26472758	Jiyoye	viability	TGACAGGGAGTGTGAGGAGGAGG	PDPK1	ENSG00000140992	2.1023207999774525	[20]	[67]	9	hSpCas9	negative selection	118424
2538115	2538138	16	+	26472758	Jiyoye	viability	GGCCAGGACCACCAGCCAGCTGG	PDPK1	ENSG00000140992	0.0050769379345276255	[110]	[83]	0	hSpCas9	negative selection	118425
2586807	2586830	16	+	26472758	Jiyoye	viability	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	1.2145303035634774	[7]	[13]	7	hSpCas9	negative selection	118426
2586862	2586885	16	+	26472758	Jiyoye	viability	TTGTTGGAGAAGCAGGCTGGCGG	PDPK1	ENSG00000140992	5.2651563766334455	[0]	[28]	9	hSpCas9	negative selection	118427
2538123	2538146	16	-	26472758	Jiyoye	viability	CGCGCTCACCAGCTGGCTGGTGG	PDPK1	ENSG00000140992	0.6127595151557674	[110]	[127]	4	hSpCas9	negative selection	118428
2586687	2586710	16	-	26472758	Jiyoye	viability	GCATGCAGCCAAACTGGCTCAGG	PDPK1	ENSG00000140992	1.577100382948186	[19]	[44]	8	hSpCas9	negative selection	118429
2586763	2586786	16	-	26472758	Jiyoye	viability	ATGTTGCTGCCTGACCTCTGGGG	PDPK1	ENSG00000140992	-2.9392750325155577	[355]	[34]	-9	hSpCas9	negative selection	118430
2586872	2586895	16	+	26472758	Jiyoye	viability	AGCAGGCTGGCGGAAACCCTTGG	PDPK1	ENSG00000140992	-3.508432431203754	[165]	[10]	-9	hSpCas9	negative selection	118431
2557924	2557947	16	+	26472758	Jiyoye	viability	CAAGTTTGGGAAAATCCTTGGGG	PDPK1	ENSG00000140992	-1.1817560214182283	[363]	[120]	-7	hSpCas9	negative selection	118432
2586836	2586859	16	+	26472758	Jiyoye	viability	AGTTTTCCGAAGATGAGAAGAGG	PDPK1	ENSG00000140992	-1.460374322470477	[207]	[56]	-7	hSpCas9	negative selection	118433
2586722	2586745	16	-	26472758	KBM7	viability	TGACAGGGAGTGTGAGGAGGAGG	PDPK1	ENSG00000140992	0.39242571437037965	[246,225]	[126,162]	4	hSpCas9	negative selection	309542
2538115	2538138	16	+	26472758	KBM7	viability	GGCCAGGACCACCAGCCAGCTGG	PDPK1	ENSG00000140992	0.578829441013187	[299,185]	[159,173]	6	hSpCas9	negative selection	309543
2586807	2586830	16	+	26472758	KBM7	viability	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-0.36404762667559787	[127,89]	[42,35]	-3	hSpCas9	negative selection	309544
2586862	2586885	16	+	26472758	KBM7	viability	TTGTTGGAGAAGCAGGCTGGCGG	PDPK1	ENSG00000140992	0.11636110985236581	[89,37]	[13,46]	1	hSpCas9	negative selection	309545
2538123	2538146	16	-	26472758	KBM7	viability	CGCGCTCACCAGCTGGCTGGTGG	PDPK1	ENSG00000140992	0.12230933572403935	[789,370]	[323,254]	1	hSpCas9	negative selection	309546
2586687	2586710	16	-	26472758	KBM7	viability	GCATGCAGCCAAACTGGCTCAGG	PDPK1	ENSG00000140992	-0.6775749267531136	[294,215]	[49,95]	-5	hSpCas9	negative selection	309547
2586763	2586786	16	-	26472758	KBM7	viability	ATGTTGCTGCCTGACCTCTGGGG	PDPK1	ENSG00000140992	-0.7093331900918014	[1276,1104]	[291,385]	-5	hSpCas9	negative selection	309548
2586872	2586895	16	+	26472758	KBM7	viability	AGCAGGCTGGCGGAAACCCTTGG	PDPK1	ENSG00000140992	-0.2936732042103389	[793,605]	[291,242]	-3	hSpCas9	negative selection	309549
2557924	2557947	16	+	26472758	KBM7	viability	CAAGTTTGGGAAAATCCTTGGGG	PDPK1	ENSG00000140992	-0.6735711087765285	[1151,882]	[337,260]	-5	hSpCas9	negative selection	309550
2586836	2586859	16	+	26472758	KBM7	viability	AGTTTTCCGAAGATGAGAAGAGG	PDPK1	ENSG00000140992	-0.7377256737961668	[819,1091]	[240,304]	-6	hSpCas9	negative selection	309551
2586722	2586745	16	-	26472758	Raji	viability	TGACAGGGAGTGTGAGGAGGAGG	PDPK1	ENSG00000140992	1.0842999222605583	[62]	[30]	8	hSpCas9	negative selection	500660
2538115	2538138	16	+	26472758	Raji	viability	GGCCAGGACCACCAGCCAGCTGG	PDPK1	ENSG00000140992	0.15318722498672432	[154]	[39]	1	hSpCas9	negative selection	500661
2586807	2586830	16	+	26472758	Raji	viability	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	0.15985095526773474	[26]	[6]	1	hSpCas9	negative selection	500662
2586862	2586885	16	+	26472758	Raji	viability	TTGTTGGAGAAGCAGGCTGGCGG	PDPK1	ENSG00000140992	1.4069438172325073	[25]	[15]	9	hSpCas9	negative selection	500663
2538123	2538146	16	-	26472758	Raji	viability	CGCGCTCACCAGCTGGCTGGTGG	PDPK1	ENSG00000140992	0.18013987780891366	[231]	[60]	1	hSpCas9	negative selection	500664
2586687	2586710	16	-	26472758	Raji	viability	GCATGCAGCCAAACTGGCTCAGG	PDPK1	ENSG00000140992	-1.0625414660687131	[134]	[14]	-7	hSpCas9	negative selection	500665
2586763	2586786	16	-	26472758	Raji	viability	ATGTTGCTGCCTGACCTCTGGGG	PDPK1	ENSG00000140992	-1.51880162807407	[567]	[45]	-8	hSpCas9	negative selection	500666
2586872	2586895	16	+	26472758	Raji	viability	AGCAGGCTGGCGGAAACCCTTGG	PDPK1	ENSG00000140992	-1.6719570105144081	[356]	[25]	-8	hSpCas9	negative selection	500667
2557924	2557947	16	+	26472758	Raji	viability	CAAGTTTGGGAAAATCCTTGGGG	PDPK1	ENSG00000140992	0.1594720465220536	[543]	[140]	1	hSpCas9	negative selection	500668
2586836	2586859	16	+	26472758	Raji	viability	AGTTTTCCGAAGATGAGAAGAGG	PDPK1	ENSG00000140992	-0.7907368506071871	[573]	[76]	-6	hSpCas9	negative selection	500669
2586722	2586745	16	-	26472758	K562	viability	TGACAGGGAGTGTGAGGAGGAGG	PDPK1	ENSG00000140992	-0.008700209302264117	[173]	[145]	0	hSpCas9	negative selection	691778
2538115	2538138	16	+	26472758	K562	viability	GGCCAGGACCACCAGCCAGCTGG	PDPK1	ENSG00000140992	0.5820517232596841	[200]	[253]	5	hSpCas9	negative selection	691779
2586807	2586830	16	+	26472758	K562	viability	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-1.7555812723335529	[95]	[23]	-7	hSpCas9	negative selection	691780
2586862	2586885	16	+	26472758	K562	viability	TTGTTGGAGAAGCAGGCTGGCGG	PDPK1	ENSG00000140992	-0.5961030583263565	[76]	[42]	-4	hSpCas9	negative selection	691781
2538123	2538146	16	-	26472758	K562	viability	CGCGCTCACCAGCTGGCTGGTGG	PDPK1	ENSG00000140992	0.900542257308842	[355]	[560]	7	hSpCas9	negative selection	691782
2586687	2586710	16	-	26472758	K562	viability	GCATGCAGCCAAACTGGCTCAGG	PDPK1	ENSG00000140992	0.972935131996835	[136]	[226]	7	hSpCas9	negative selection	691783
2586763	2586786	16	-	26472758	K562	viability	ATGTTGCTGCCTGACCTCTGGGG	PDPK1	ENSG00000140992	-0.8186266046575891	[724]	[346]	-5	hSpCas9	negative selection	691784
2586872	2586895	16	+	26472758	K562	viability	AGCAGGCTGGCGGAAACCCTTGG	PDPK1	ENSG00000140992	-0.9586731377110649	[593]	[257]	-5	hSpCas9	negative selection	691785
2557924	2557947	16	+	26472758	K562	viability	CAAGTTTGGGAAAATCCTTGGGG	PDPK1	ENSG00000140992	-0.6246205944503903	[883]	[483]	-4	hSpCas9	negative selection	691786
2586836	2586859	16	+	26472758	K562	viability	AGTTTTCCGAAGATGAGAAGAGG	PDPK1	ENSG00000140992	-0.6815806908897764	[873]	[459]	-4	hSpCas9	negative selection	691787
2586807	2586830	16	+	26627737	DLD1	viability	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-0.015722052164318268	[569]	[184,170,172]	0	hSpCas9	negative selection	793350
2595829	2595852	16	+	26627737	DLD1	viability	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-2.314637855884982	[170]	[10,14,6]	-9	hSpCas9	negative selection	793351
2597216	2597239	16	-	26627737	DLD1	viability	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	1.484069600847301	[151]	[135,195,77]	9	hSpCas9	negative selection	793352
2597679	2597702	16	-	26627737	DLD1	viability	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	0.17064836458558352	[588]	[248,257,128]	1	hSpCas9	negative selection	793353
2597728	2597751	16	+	26627737	DLD1	viability	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	-0.9392985005914101	[306]	[76,39,34]	-7	hSpCas9	negative selection	793354
2586807	2586830	16	+	26627737	GBM cells	viability after 5 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	0.09990093261886279	[387]	[210,234]	1	hSpCas9	negative selection	875665
2595829	2595852	16	+	26627737	GBM cells	viability after 5 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-0.4086589270246066	[124]	[42,57]	-6	hSpCas9	negative selection	875666
2597216	2597239	16	-	26627737	GBM cells	viability after 5 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	0.22572419115279385	[117]	[81,65]	3	hSpCas9	negative selection	875667
2597679	2597702	16	-	26627737	GBM cells	viability after 5 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	0.35039337013258953	[214]	[149,143]	5	hSpCas9	negative selection	875668
2597728	2597751	16	+	26627737	GBM cells	viability after 5 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	-0.2615507973075606	[132]	[73,44]	-4	hSpCas9	negative selection	875669
2586807	2586830	16	+	26627737	GBM cells	viability after 13 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	0.44220997490189706	[387]	[274,294]	5	hSpCas9	negative selection	957980
2595829	2595852	16	+	26627737	GBM cells	viability after 13 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-0.6715472208442252	[124]	[30,51]	-7	hSpCas9	negative selection	957981
2597216	2597239	16	-	26627737	GBM cells	viability after 13 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	0.22488018825062206	[117]	[65,81]	3	hSpCas9	negative selection	957982
2597679	2597702	16	-	26627737	GBM cells	viability after 13 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	0.19333426815453258	[214]	[139,127]	2	hSpCas9	negative selection	957983
2597728	2597751	16	+	26627737	GBM cells	viability after 13 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	0.2987349373536021	[132]	[101,77]	4	hSpCas9	negative selection	957984
2586807	2586830	16	+	26627737	GBM cells	viability after 21 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	0.10234239513798105	[387]	[242,210]	1	hSpCas9	negative selection	1040295
2595829	2595852	16	+	26627737	GBM cells	viability after 21 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-0.3673415981358721	[124]	[60,44]	-3	hSpCas9	negative selection	1040296
2597216	2597239	16	-	26627737	GBM cells	viability after 21 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	0.09959509278236578	[117]	[75,61]	1	hSpCas9	negative selection	1040297
2597679	2597702	16	-	26627737	GBM cells	viability after 21 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	0.196573657794331	[214]	[148,119]	2	hSpCas9	negative selection	1040298
2597728	2597751	16	+	26627737	GBM cells	viability after 21 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	0.1893287451267872	[132]	[84,79]	2	hSpCas9	negative selection	1040299
2586807	2586830	16	+	26627737	RPE1	viability after 9 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-1.132566603155423	[1265]	[192,164]	-7	hSpCas9	negative selection	1122610
2595829	2595852	16	+	26627737	RPE1	viability after 9 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-0.9297596627538915	[186]	[21,41]	-6	hSpCas9	negative selection	1122611
2597216	2597239	16	-	26627737	RPE1	viability after 9 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	0.6942536805190356	[233]	[42,215]	4	hSpCas9	negative selection	1122612
2597679	2597702	16	-	26627737	RPE1	viability after 9 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	-0.9340417436855019	[1310]	[185,251]	-6	hSpCas9	negative selection	1122613
2597728	2597751	16	+	26627737	RPE1	viability after 9 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	-0.33507238497046665	[379]	[61,135]	-2	hSpCas9	negative selection	1122614
2586807	2586830	16	+	26627737	RPE1	viability after 12 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-1.3799926442884973	[1265]	[187,69]	-7	hSpCas9	negative selection	1204925
2595829	2595852	16	+	26627737	RPE1	viability after 12 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-1.843428126156895	[186]	[13,13]	-8	hSpCas9	negative selection	1204926
2597216	2597239	16	-	26627737	RPE1	viability after 12 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	0.28878109792352724	[233]	[52,101]	2	hSpCas9	negative selection	1204927
2597679	2597702	16	-	26627737	RPE1	viability after 12 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	-0.6763601448648215	[1310]	[199,241]	-5	hSpCas9	negative selection	1204928
2597728	2597751	16	+	26627737	RPE1	viability after 12 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	-0.8871478347670032	[379]	[44,65]	-6	hSpCas9	negative selection	1204929
2586807	2586830	16	+	26627737	RPE1	viability after 15 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-1.6390214575242765	[1265]	[143,86]	-7	hSpCas9	negative selection	1287240
2595829	2595852	16	+	26627737	RPE1	viability after 15 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-2.6148246741916155	[186]	[0,15]	-8	hSpCas9	negative selection	1287241
2597216	2597239	16	-	26627737	RPE1	viability after 15 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	0.8784246758717911	[233]	[82,158]	5	hSpCas9	negative selection	1287242
2597679	2597702	16	-	26627737	RPE1	viability after 15 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	-0.7886980363694939	[1310]	[232,196]	-5	hSpCas9	negative selection	1287243
2597728	2597751	16	+	26627737	RPE1	viability after 15 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	0.2162145295008967	[379]	[131,117]	1	hSpCas9	negative selection	1287244
2586807	2586830	16	+	26627737	RPE1	viability after 18 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-1.8321433354358359	[1265]	[79,112]	-8	hSpCas9	negative selection	1369555
2595829	2595852	16	+	26627737	RPE1	viability after 18 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-5.657226199786894	[186]	[0,0]	-9	hSpCas9	negative selection	1369556
2597216	2597239	16	-	26627737	RPE1	viability after 18 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	0.11458806028487922	[233]	[49,87]	0	hSpCas9	negative selection	1369557
2597679	2597702	16	-	26627737	RPE1	viability after 18 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	-2.936844371614663	[1310]	[22,70]	-9	hSpCas9	negative selection	1369558
2597728	2597751	16	+	26627737	RPE1	viability after 18 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	-0.6442091036830977	[379]	[68,61]	-4	hSpCas9	negative selection	1369559
2586807	2586830	16	+	26627737	HeLa	viability after 8 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-0.951026868362972	[823]	[238,229,104]	-7	hSpCas9	negative selection	1451870
2595829	2595852	16	+	26627737	HeLa	viability after 8 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-1.6619149927009174	[271]	[28,8,69]	-9	hSpCas9	negative selection	1451871
2597216	2597239	16	-	26627737	HeLa	viability after 8 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	0.38371127899893065	[270]	[225,105,145]	3	hSpCas9	negative selection	1451872
2597679	2597702	16	-	26627737	HeLa	viability after 8 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	-0.20335522309481008	[468]	[297,107,153]	-2	hSpCas9	negative selection	1451873
2597728	2597751	16	+	26627737	HeLa	viability after 8 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	-0.23069826886035294	[301]	[186,75,90]	-2	hSpCas9	negative selection	1451874
2586807	2586830	16	+	26627737	HeLa	viability after 12 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-0.6941124263702445	[823]	[226,237,163]	-6	hSpCas9	negative selection	1534185
2595829	2595852	16	+	26627737	HeLa	viability after 12 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-1.931707773294542	[271]	[21,49,13]	-9	hSpCas9	negative selection	1534186
2597216	2597239	16	-	26627737	HeLa	viability after 12 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	0.6852109528748783	[270]	[429,14,119]	5	hSpCas9	negative selection	1534187
2597679	2597702	16	-	26627737	HeLa	viability after 12 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	0.35174136723261895	[468]	[382,227,136]	3	hSpCas9	negative selection	1534188
2597728	2597751	16	+	26627737	HeLa	viability after 12 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	0.5320418911223045	[301]	[295,130,122]	4	hSpCas9	negative selection	1534189
2586807	2586830	16	+	26627737	HeLa	viability after 15 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-1.0937697868087182	[823]	[170,110,191]	-7	hSpCas9	negative selection	1616500
2595829	2595852	16	+	26627737	HeLa	viability after 15 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-0.8961926605720316	[271]	[99,5,72]	-7	hSpCas9	negative selection	1616501
2597216	2597239	16	-	26627737	HeLa	viability after 15 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	-0.18447435325535577	[270]	[118,1,175]	-1	hSpCas9	negative selection	1616502
2597679	2597702	16	-	26627737	HeLa	viability after 15 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	0.3888654533262932	[468]	[137,247,374]	3	hSpCas9	negative selection	1616503
2597728	2597751	16	+	26627737	HeLa	viability after 15 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	-0.7864030350514568	[301]	[64,112,32]	-6	hSpCas9	negative selection	1616504
2586807	2586830	16	+	26627737	HeLa	viability after 18 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-1.132335075865272	[823]	[108,88,191]	-7	hSpCas9	negative selection	1698815
2595829	2595852	16	+	26627737	HeLa	viability after 18 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-0.8264897506999433	[271]	[71,5,72]	-6	hSpCas9	negative selection	1698816
2597216	2597239	16	-	26627737	HeLa	viability after 18 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	-0.18883561227189583	[270]	[78,1,175]	-2	hSpCas9	negative selection	1698817
2597679	2597702	16	-	26627737	HeLa	viability after 18 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	0.3791200070307321	[468]	[87,206,374]	3	hSpCas9	negative selection	1698818
2597728	2597751	16	+	26627737	HeLa	viability after 18 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	-0.7041626045011402	[301]	[44,101,32]	-6	hSpCas9	negative selection	1698819
2586807	2586830	16	+	26627737	HCT116	viability after 6 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-0.9408486800248698	[1219]	[242,20]	-5	hSpCas9	negative selection	1781130
2595829	2595852	16	+	26627737	HCT116	viability after 6 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-0.6760388782132087	[296]	[25,30]	-4	hSpCas9	negative selection	1781131
2597216	2597239	16	-	26627737	HCT116	viability after 6 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	0.45299241590847583	[240]	[76,37]	2	hSpCas9	negative selection	1781132
2597679	2597702	16	-	26627737	HCT116	viability after 6 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	0.3454029847951766	[570]	[95,123]	2	hSpCas9	negative selection	1781133
2597728	2597751	16	+	26627737	HCT116	viability after 6 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	3.8453648173880235	[65]	[123,162]	9	hSpCas9	negative selection	1781134
2586807	2586830	16	+	26627737	HCT116	viability after 8 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	0.624201051276718	[308]	[193,320,270]	6	hSpCas9	negative selection	1863445
2595829	2595852	16	+	26627737	HCT116	viability after 8 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-2.4220872307824357	[257]	[33,42,2]	-9	hSpCas9	negative selection	1863446
2597216	2597239	16	-	26627737	HCT116	viability after 8 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	0.7668645053859494	[165]	[141,194,129]	7	hSpCas9	negative selection	1863447
2597679	2597702	16	-	26627737	HCT116	viability after 8 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	-0.09153987260924738	[277]	[205,130,95]	-1	hSpCas9	negative selection	1863448
2597728	2597751	16	+	26627737	HCT116	viability after 8 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	-0.7021112805369267	[337]	[53,143,143]	-7	hSpCas9	negative selection	1863449
2586807	2586830	16	+	26627737	HCT116	viability after 9 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-0.43559546938569815	[1219]	[265,220]	-3	hSpCas9	negative selection	1945760
2595829	2595852	16	+	26627737	HCT116	viability after 9 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-0.37965771400341475	[296]	[89,37]	-3	hSpCas9	negative selection	1945761
2597216	2597239	16	-	26627737	HCT116	viability after 9 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	-0.10599983233377808	[240]	[56,61]	0	hSpCas9	negative selection	1945762
2597679	2597702	16	-	26627737	HCT116	viability after 9 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	0.5720713114071712	[570]	[391,95]	4	hSpCas9	negative selection	1945763
2597728	2597751	16	+	26627737	HCT116	viability after 9 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	2.0552194626072993	[65]	[151,10]	9	hSpCas9	negative selection	1945764
2586807	2586830	16	+	26627737	HCT116	viability after 12 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	0.8263413292380155	[308]	[336,348,174]	7	hSpCas9	negative selection	2028075
2595829	2595852	16	+	26627737	HCT116	viability after 12 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-4.244862584838651	[257]	[11,5,2]	-9	hSpCas9	negative selection	2028076
2597216	2597239	16	-	26627737	HCT116	viability after 12 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	0.7769484824647345	[165]	[92,173,186]	7	hSpCas9	negative selection	2028077
2597679	2597702	16	-	26627737	HCT116	viability after 12 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	0.8679833200195536	[277]	[274,134,385]	7	hSpCas9	negative selection	2028078
2597728	2597751	16	+	26627737	HCT116	viability after 12 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	-1.3198368316981963	[337]	[76,31,102]	-8	hSpCas9	negative selection	2028079
2586807	2586830	16	+	26627737	HCT116	viability after 15 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	0.8844557925804837	[308]	[359,403,223]	7	hSpCas9	negative selection	2110390
2595829	2595852	16	+	26627737	HCT116	viability after 15 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-2.9449903954621797	[257]	[22,0,33]	-9	hSpCas9	negative selection	2110391
2597216	2597239	16	-	26627737	HCT116	viability after 15 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	0.5196963712540266	[165]	[33,182,179]	5	hSpCas9	negative selection	2110392
2597679	2597702	16	-	26627737	HCT116	viability after 15 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	-0.13963272943688015	[277]	[70,144,208]	-1	hSpCas9	negative selection	2110393
2597728	2597751	16	+	26627737	HCT116	viability after 15 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	-0.9536576001776962	[337]	[104,74,120]	-7	hSpCas9	negative selection	2110394
2586807	2586830	16	+	26627737	HCT116	viability after 18 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	0.842423600427752	[308]	[292,330,170]	6	hSpCas9	negative selection	2192705
2595829	2595852	16	+	26627737	HCT116	viability after 18 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-2.578186215910593	[257]	[16,10,35]	-9	hSpCas9	negative selection	2192706
2597216	2597239	16	-	26627737	HCT116	viability after 18 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	0.29900188044069653	[165]	[70,128,93]	2	hSpCas9	negative selection	2192707
2597679	2597702	16	-	26627737	HCT116	viability after 18 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	0.32573292804654586	[277]	[252,127,124]	3	hSpCas9	negative selection	2192708
2597728	2597751	16	+	26627737	HCT116	viability after 18 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	-0.6142665593495641	[337]	[100,16,212]	-5	hSpCas9	negative selection	2192709
2538110	2538133	16	-	24336569	HL60	viability	TGGCTGGTGGTCCTGGCCATGGG	PDPK1	ENSG00000140992	-0.09176910902063481	[561]	[1115]	-1	hSpCas9	negative selection	2283393
2538115	2538138	16	+	24336569	HL60	viability	GGCCAGGACCACCAGCCAGCTGG	PDPK1	ENSG00000140992	0.12647066606178325	[744]	[1720]	1	hSpCas9	negative selection	2283394
2538123	2538146	16	-	24336569	HL60	viability	CGCGCTCACCAGCTGGCTGGTGG	PDPK1	ENSG00000140992	0.5174107069475141	[515]	[1562]	4	hSpCas9	negative selection	2283395
2586679	2586702	16	+	24336569	HL60	viability	GACAATCTCCTGAGCCAGTTTGG	PDPK1	ENSG00000140992	0.5873542801222157	[478]	[1522]	5	hSpCas9	negative selection	2283396
2586687	2586710	16	-	24336569	HL60	viability	GCATGCAGCCAAACTGGCTCAGG	PDPK1	ENSG00000140992	-0.8579397098025283	[363]	[424]	-7	hSpCas9	negative selection	2283397
2586693	2586716	16	-	24336569	HL60	viability	ACACCTGCATGCAGCCAAACTGG	PDPK1	ENSG00000140992	0.5767082470460364	[729]	[2303]	5	hSpCas9	negative selection	2283398
2586722	2586745	16	-	24336569	HL60	viability	TGACAGGGAGTGTGAGGAGGAGG	PDPK1	ENSG00000140992	0.26000418065411113	[1055]	[2675]	2	hSpCas9	negative selection	2283399
2586735	2586758	16	+	24336569	HL60	viability	CTCCCTGTCAGCCTCCGACACGG	PDPK1	ENSG00000140992	-1.2348438115838252	[465]	[418]	-8	hSpCas9	negative selection	2283400
2586764	2586787	16	-	24336569	HL60	viability	TATGTTGCTGCCTGACCTCTGGG	PDPK1	ENSG00000140992	0.4199849044258954	[645]	[1828]	4	hSpCas9	negative selection	2283401
2586786	2586809	16	+	24336569	HL60	viability	AGAGCAGTACATTCACGATCTGG	PDPK1	ENSG00000140992	-0.0033489352842723807	[673]	[1422]	0	hSpCas9	negative selection	2283402
2538110	2538133	16	-	24336569	KBM7	viability	TGGCTGGTGGTCCTGGCCATGGG	PDPK1	ENSG00000140992	-0.6111769164499619	[582]	[1040]	-5	hSpCas9	negative selection	2350570
2538115	2538138	16	+	24336569	KBM7	viability	GGCCAGGACCACCAGCCAGCTGG	PDPK1	ENSG00000140992	0.495330236053914	[682]	[2625]	4	hSpCas9	negative selection	2350571
2538123	2538146	16	-	24336569	KBM7	viability	CGCGCTCACCAGCTGGCTGGTGG	PDPK1	ENSG00000140992	0.38086230137428645	[358]	[1274]	3	hSpCas9	negative selection	2350572
2586679	2586702	16	+	24336569	KBM7	viability	GACAATCTCCTGAGCCAGTTTGG	PDPK1	ENSG00000140992	0.31759127887644695	[465]	[1583]	3	hSpCas9	negative selection	2350573
2586687	2586710	16	-	24336569	KBM7	viability	GCATGCAGCCAAACTGGCTCAGG	PDPK1	ENSG00000140992	-2.3412078927484785	[378]	[203]	-8	hSpCas9	negative selection	2350574
2586693	2586716	16	-	24336569	KBM7	viability	ACACCTGCATGCAGCCAAACTGG	PDPK1	ENSG00000140992	0.7335627905992437	[483]	[2194]	6	hSpCas9	negative selection	2350575
2586722	2586745	16	-	24336569	KBM7	viability	TGACAGGGAGTGTGAGGAGGAGG	PDPK1	ENSG00000140992	-0.5579665923721997	[895]	[1659]	-4	hSpCas9	negative selection	2350576
2586735	2586758	16	+	24336569	KBM7	viability	CTCCCTGTCAGCCTCCGACACGG	PDPK1	ENSG00000140992	0.12867660882137466	[276]	[825]	1	hSpCas9	negative selection	2350577
2586764	2586787	16	-	24336569	KBM7	viability	TATGTTGCTGCCTGACCTCTGGG	PDPK1	ENSG00000140992	0.8405461902477417	[664]	[3247]	7	hSpCas9	negative selection	2350578
2586786	2586809	16	+	24336569	KBM7	viability	AGAGCAGTACATTCACGATCTGG	PDPK1	ENSG00000140992	-0.23333897097589357	[430]	[999]	-2	hSpCas9	negative selection	2350579
2573633	2573656	16	+	25494202	A375	resistance to PLX-4720 (puromycin)	GTGGGAGGATCGCTTGAACCCGG	PDPK1	ENSG00000140992	1.8116858574874066	[53,40]	[28,44]	6	dCas9-VP64	positive selection	2415081
2590986	2591009	16	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGAGTCTCATTCTGTCGCCCAGG	PDPK1	ENSG00000140992	1.2945245935016754	[8,39]	[14,10]	5	dCas9-VP64	positive selection	2416732
2546237	2546260	16	-	25494202	A375	resistance to PLX-4720 (puromycin)	ACACAAAAATTAGCCGGGCGCAG	PDPK1	ENSG00000140992	-0.8999059485131444	[15,116]	[8,5]	-5	dCas9-VP64	positive selection	2433119
2573633	2573656	16	+	25494202	A375	resistance to PLX-4720 (zeocin)	GTGGGAGGATCGCTTGAACCCGG	PDPK1	ENSG00000140992	-0.34921714426071837	[183,162]	[58,29]	-4	dCas9-VP64	positive selection	2510336
2590986	2591009	16	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGAGTCTCATTCTGTCGCCCAGG	PDPK1	ENSG00000140992	0.5675992743301584	[132,99]	[41,68]	4	dCas9-VP64	positive selection	2511987
2546237	2546260	16	-	25494202	A375	resistance to PLX-4720 (zeocin)	ACACAAAAATTAGCCGGGCGCAG	PDPK1	ENSG00000140992	-0.9472939245344096	[73,17]	[10,3]	-8	dCas9-VP64	positive selection	2528374
2557790	2557813	16	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CTGCCACCAGGAATGCCAGGGGG	PDPK1	ENSG00000140992	0.5788252889103837	[3,3]	[3,5]	9	hSpCas9	positive selection	3010544
2581685	2581708	16	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TTACCAAAAGTTTCTCCACGAGG	PDPK1	ENSG00000140992	-1.1298163570874828	[3,3]	[1,0]	-9	hSpCas9	positive selection	3010545
2583434	2583457	16	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TTAGGCTGTGAGGAAATGGAAGG	PDPK1	ENSG00000140992	0.26979032614093124	[5,4]	[3,6]	6	hSpCas9	positive selection	3010546
2581301	2581324	16	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TTATGCATCCAAGAGCCCAAAGG	PDPK1	ENSG00000140992	-0.9774088499824762	[3,2]	[1,0]	-9	hSpCas9	positive selection	3010547
2557790	2557813	16	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CTGCCACCAGGAATGCCAGGGGG	PDPK1	ENSG00000140992	0.061339665246308045	[3,3]	[4,0]	1	hSpCas9	positive selection	3078402
2581685	2581708	16	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TTACCAAAAGTTTCTCCACGAGG	PDPK1	ENSG00000140992	-0.3729806703043007	[3,3]	[1,0]	-5	hSpCas9	positive selection	3078403
2583434	2583457	16	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TTAGGCTGTGAGGAAATGGAAGG	PDPK1	ENSG00000140992	-0.02289316600641217	[5,5]	[4,2]	0	hSpCas9	positive selection	3078404
2581301	2581324	16	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TTATGCATCCAAGAGCCCAAAGG	PDPK1	ENSG00000140992	-0.8667034706450935	[3,3]	[1,0]	-9	hSpCas9	positive selection	3078405
2581685	2581708	16	-	27383988	293T	resistance to West Nile virus (flavivirus)	TTACCAAAAGTTTCTCCACGAGG	PDPK1	ENSG00000140992	2.672363710724679	[23,23]	[0,0]	8	hSpCas9	positive selection	3385248
2581622	2581645	16	+	27383988	293T	resistance to West Nile virus (flavivirus)	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.556454979771202	[224,224]	[0,0]	-4	hSpCas9	positive selection	3385249
2557790	2557813	16	-	26780180	HT29	viability (Avana library 4 designs)	CTGCCACCAGGAATGCCAGGGGG	PDPK1	ENSG00000140992	0.881065707139561	[]	[]	3	hSpCas9	negative selection	3448601
2581685	2581708	16	-	26780180	HT29	viability (Avana library 4 designs)	TTACCAAAAGTTTCTCCACGAGG	PDPK1	ENSG00000140992	2.03231049342738	[]	[]	7	hSpCas9	negative selection	3448602
2583433	2583456	16	+	26780180	HT29	viability (Avana library 4 designs)	TTAGGCTGTGAGGAAATGGAAGG	PDPK1	ENSG00000140992	3.44637001570028	[]	[]	9	hSpCas9	negative selection	3448603
2581301	2581324	16	-	26780180	HT29	viability (Avana library 4 designs)	TTATGCATCCAAGAGCCCAAAGG	PDPK1	ENSG00000140992	6.08043549807686	[]	[]	9	hSpCas9	negative selection	3448604
2581301	2581324	16	-	26780180	A375	viability (Avana lentiCRISPRv2)	TTATGCATCCAAGAGCCCAAAGG	PDPK1	ENSG00000140992	-11.9343280502533	[]	[]	-8	hSpCas9	negative selection	3542961
2581685	2581708	16	-	26780180	A375	viability (Avana lentiCRISPRv2)	TTACCAAAAGTTTCTCCACGAGG	PDPK1	ENSG00000140992	2.07279456417394	[]	[]	3	hSpCas9	negative selection	3542962
2557790	2557813	16	-	26780180	A375	viability (Avana lentiCRISPRv2)	CTGCCACCAGGAATGCCAGGGGG	PDPK1	ENSG00000140992	-1.75691669225803	[]	[]	-2	hSpCas9	negative selection	3542963
2583433	2583456	16	+	26780180	A375	viability (Avana lentiCRISPRv2)	TTAGGCTGTGAGGAAATGGAAGG	PDPK1	ENSG00000140992	-9.876558511938	[]	[]	-7	hSpCas9	negative selection	3542964
2577488	2577511	16	-	26780180	A375	viability (Avana lentiCRISPRv2)	AAGTGGTTACCTCTTACAGGCGG	PDPK1	ENSG00000140992	-11.3876912310394	[]	[]	-8	hSpCas9	negative selection	3542965
2581670	2581693	16	-	26780180	A375	viability (Avana lentiCRISPRv2)	CCACGAGGTCTCTTGCCTTAGGG	PDPK1	ENSG00000140992	5.91222619913959	[]	[]	9	hSpCas9	negative selection	3542966
2581301	2581324	16	-	26780180	A375	viability (Avana lentiGuide)	TTATGCATCCAAGAGCCCAAAGG	PDPK1	ENSG00000140992	20.278998410249	[]	[]	8	hSpCas9	negative selection	3651620
2581685	2581708	16	-	26780180	A375	viability (Avana lentiGuide)	TTACCAAAAGTTTCTCCACGAGG	PDPK1	ENSG00000140992	7.17569996220124	[]	[]	5	hSpCas9	negative selection	3651621
2557790	2557813	16	-	26780180	A375	viability (Avana lentiGuide)	CTGCCACCAGGAATGCCAGGGGG	PDPK1	ENSG00000140992	-0.464669575781844	[]	[]	0	hSpCas9	negative selection	3651622
2583433	2583456	16	+	26780180	A375	viability (Avana lentiGuide)	TTAGGCTGTGAGGAAATGGAAGG	PDPK1	ENSG00000140992	18.561107569064	[]	[]	8	hSpCas9	negative selection	3651623
2577488	2577511	16	-	26780180	A375	viability (Avana lentiGuide)	AAGTGGTTACCTCTTACAGGCGG	PDPK1	ENSG00000140992	26.5706212380595	[]	[]	9	hSpCas9	negative selection	3651624
2581670	2581693	16	-	26780180	A375	viability (Avana lentiGuide)	CCACGAGGTCTCTTGCCTTAGGG	PDPK1	ENSG00000140992	-3.56920864607291	[]	[]	-6	hSpCas9	negative selection	3651625
2581301	2581324	16	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTATGCATCCAAGAGCCCAAAGG	PDPK1	ENSG00000140992	-1.5660092109063124	[5]	[1,1]	-9	hSpCas9	positive selection	3760279
2581685	2581708	16	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTACCAAAAGTTTCTCCACGAGG	PDPK1	ENSG00000140992	0.12788510718680052	[5]	[5,5]	3	hSpCas9	positive selection	3760280
2557790	2557813	16	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CTGCCACCAGGAATGCCAGGGGG	PDPK1	ENSG00000140992	-0.49316825773173956	[3]	[4,0]	-6	hSpCas9	positive selection	3760281
2583433	2583456	16	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTAGGCTGTGAGGAAATGGAAGG	PDPK1	ENSG00000140992	-0.3330082658825435	[7]	[5,4]	-5	hSpCas9	positive selection	3760282
2577488	2577511	16	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AAGTGGTTACCTCTTACAGGCGG	PDPK1	ENSG00000140992	-0.35660440592954157	[5]	[3,4]	-5	hSpCas9	positive selection	3760283
2581670	2581693	16	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CCACGAGGTCTCTTGCCTTAGGG	PDPK1	ENSG00000140992	0.23696937758314138	[5]	[6,5]	6	hSpCas9	positive selection	3760284
2581301	2581324	16	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTATGCATCCAAGAGCCCAAAGG	PDPK1	ENSG00000140992	-0.7015953147716677	[5]	[0,4]	-7	hSpCas9	positive selection	3868886
2581685	2581708	16	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTACCAAAAGTTTCTCCACGAGG	PDPK1	ENSG00000140992	-0.17320812335736205	[5]	[5,2]	-2	hSpCas9	positive selection	3868887
2557790	2557813	16	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CTGCCACCAGGAATGCCAGGGGG	PDPK1	ENSG00000140992	-0.8815567569070435	[4]	[0,2]	-8	hSpCas9	positive selection	3868888
2583433	2583456	16	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTAGGCTGTGAGGAAATGGAAGG	PDPK1	ENSG00000140992	-0.15662621233686397	[7]	[5,5]	-2	hSpCas9	positive selection	3868889
2577488	2577511	16	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AAGTGGTTACCTCTTACAGGCGG	PDPK1	ENSG00000140992	-1.0934713179145095	[5]	[0,1]	-8	hSpCas9	positive selection	3868890
2581670	2581693	16	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CCACGAGGTCTCTTGCCTTAGGG	PDPK1	ENSG00000140992	0.2916370535817278	[5]	[6,5]	7	hSpCas9	positive selection	3868891
2581622	2581645	16	+	26780180	A375	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	1.93298812679657	[]	[]	9	hSpCas9	negative selection	3979660
2581622	2581645	16	+	26780180	HT29	viability (GeCKOv2 library)	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	1.06494412262466	[]	[]	5	hSpCas9	negative selection	4087626
2581622	2581645	16	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.07364305487559535	[3]	[3,1]	-1	hSpCas9	positive selection	4353834
2581301	2581323	16	-	27760321	OCIAML3	viability	TATGCATCCAAGAGCCCAAAGG	PDPK1	ENSG00000140992	-1.4751490516561383	[353,293]	[98,79]	-8	hSpCas9	negative selection	4426780
2581343	2581365	16	+	27760321	OCIAML3	viability	ACTCCCACCATTCCGAGCTGGG	PDPK1	ENSG00000140992	-1.7878464376466372	[1173,1010]	[221,278]	-9	hSpCas9	negative selection	4426781
2581671	2581693	16	+	27760321	OCIAML3	viability	CCTAAGGCAAGAGACCTCGTGG	PDPK1	ENSG00000140992	-1.2952343240390116	[295,265]	[98,76]	-8	hSpCas9	negative selection	4426782
2581685	2581707	16	-	27760321	OCIAML3	viability	TACCAAAAGTTTCTCCACGAGG	PDPK1	ENSG00000140992	0.349869932207314	[0,0]	[0,0]	4	hSpCas9	negative selection	4426783
2581301	2581323	16	-	27760321	OCIAML2	viability	TATGCATCCAAGAGCCCAAAGG	PDPK1	ENSG00000140992	-2.7532915811508216	[353,293]	[39,36]	-9	hSpCas9	negative selection	4510243
2581343	2581365	16	+	27760321	OCIAML2	viability	ACTCCCACCATTCCGAGCTGGG	PDPK1	ENSG00000140992	-1.7783483692755433	[1173,1010]	[186,348]	-9	hSpCas9	negative selection	4510244
2581671	2581693	16	+	27760321	OCIAML2	viability	CCTAAGGCAAGAGACCTCGTGG	PDPK1	ENSG00000140992	-1.486028807034816	[295,265]	[71,92]	-8	hSpCas9	negative selection	4510245
2581685	2581707	16	-	27760321	OCIAML2	viability	TACCAAAAGTTTCTCCACGAGG	PDPK1	ENSG00000140992	0.3011245669422653	[0,0]	[0,0]	4	hSpCas9	negative selection	4510246
2581301	2581323	16	-	27760321	MV411	viability	TATGCATCCAAGAGCCCAAAGG	PDPK1	ENSG00000140992	-0.6675555466489358	[353,293]	[165,85]	-4	hSpCas9	negative selection	4593706
2581343	2581365	16	+	27760321	MV411	viability	ACTCCCACCATTCCGAGCTGGG	PDPK1	ENSG00000140992	-0.17940802979744608	[1173,1010]	[671,578]	-1	hSpCas9	negative selection	4593707
2581671	2581693	16	+	27760321	MV411	viability	CCTAAGGCAAGAGACCTCGTGG	PDPK1	ENSG00000140992	-2.7466360100577845	[295,265]	[25,29]	-9	hSpCas9	negative selection	4593708
2581685	2581707	16	-	27760321	MV411	viability	TACCAAAAGTTTCTCCACGAGG	PDPK1	ENSG00000140992	0.5949485011219959	[0,0]	[0,0]	4	hSpCas9	negative selection	4593709
2581301	2581323	16	-	27760321	HL60	viability	TATGCATCCAAGAGCCCAAAGG	PDPK1	ENSG00000140992	-1.4058737661071057	[353,293]	[130,65]	-8	hSpCas9	negative selection	4677169
2581343	2581365	16	+	27760321	HL60	viability	ACTCCCACCATTCCGAGCTGGG	PDPK1	ENSG00000140992	-1.3737533498862735	[1173,1010]	[306,381]	-8	hSpCas9	negative selection	4677170
2581671	2581693	16	+	27760321	HL60	viability	CCTAAGGCAAGAGACCTCGTGG	PDPK1	ENSG00000140992	-1.4324236375463064	[295,265]	[99,68]	-8	hSpCas9	negative selection	4677171
2581685	2581707	16	-	27760321	HL60	viability	TACCAAAAGTTTCTCCACGAGG	PDPK1	ENSG00000140992	0.2870783393278593	[0,0]	[0,0]	3	hSpCas9	negative selection	4677172
2581301	2581323	16	-	27760321	HT1080	viability	TATGCATCCAAGAGCCCAAAGG	PDPK1	ENSG00000140992	-6.705817308012432	[293,229]	[0,0]	-9	hSpCas9	negative selection	4760632
2581343	2581365	16	+	27760321	HT1080	viability	ACTCCCACCATTCCGAGCTGGG	PDPK1	ENSG00000140992	-8.485958632604945	[1010,788]	[0,0]	-9	hSpCas9	negative selection	4760633
2581671	2581693	16	+	27760321	HT1080	viability	CCTAAGGCAAGAGACCTCGTGG	PDPK1	ENSG00000140992	-6.561096672986329	[265,207]	[0,0]	-9	hSpCas9	negative selection	4760634
2581685	2581707	16	-	27760321	HT1080	viability	TACCAAAAGTTTCTCCACGAGG	PDPK1	ENSG00000140992	1.3056276939190559	[0,0]	[0,0]	7	hSpCas9	negative selection	4760635
2581301	2581323	16	-	27760321	HT29	viability after 7 days	TATGCATCCAAGAGCCCAAAGG	PDPK1	ENSG00000140992	-0.7670513770804128	[293,229]	[197,113,278]	-8	hSpCas9	negative selection	4844095
2581343	2581365	16	+	27760321	HT29	viability after 7 days	ACTCCCACCATTCCGAGCTGGG	PDPK1	ENSG00000140992	-0.24374764643017643	[1010,788]	[1035,933,968]	-4	hSpCas9	negative selection	4844096
2581671	2581693	16	+	27760321	HT29	viability after 7 days	CCTAAGGCAAGAGACCTCGTGG	PDPK1	ENSG00000140992	-0.48280089379797797	[265,207]	[186,260,201]	-6	hSpCas9	negative selection	4844097
2581685	2581707	16	-	27760321	HT29	viability after 7 days	TACCAAAAGTTTCTCCACGAGG	PDPK1	ENSG00000140992	-0.3840325596302083	[0,0]	[0,0,0]	-5	hSpCas9	negative selection	4844098
2581301	2581323	16	-	27760321	HT29	viability after 25 days	TATGCATCCAAGAGCCCAAAGG	PDPK1	ENSG00000140992	-8.225499572858956	[293,229]	[0,0,0]	-9	hSpCas9	negative selection	4927558
2581343	2581365	16	+	27760321	HT29	viability after 25 days	ACTCCCACCATTCCGAGCTGGG	PDPK1	ENSG00000140992	-4.6805994795505415	[1010,788]	[0,61,61]	-9	hSpCas9	negative selection	4927559
2581671	2581693	16	+	27760321	HT29	viability after 25 days	CCTAAGGCAAGAGACCTCGTGG	PDPK1	ENSG00000140992	-3.406201021328073	[265,207]	[0,52,23]	-9	hSpCas9	negative selection	4927560
2581685	2581707	16	-	27760321	HT29	viability after 25 days	TACCAAAAGTTTCTCCACGAGG	PDPK1	ENSG00000140992	-0.21405457092746794	[0,0]	[0,0,0]	-2	hSpCas9	negative selection	4927561
2581301	2581323	16	-	27760321	HT29	viability after 22 days	TATGCATCCAAGAGCCCAAAGG	PDPK1	ENSG00000140992	-7.247019264503861	[293,229]	[0,3,0]	-9	hSpCas9	negative selection	5011021
2581343	2581365	16	+	27760321	HT29	viability after 22 days	ACTCCCACCATTCCGAGCTGGG	PDPK1	ENSG00000140992	-3.4456352301045143	[1010,788]	[74,119,91]	-9	hSpCas9	negative selection	5011022
2581671	2581693	16	+	27760321	HT29	viability after 22 days	CCTAAGGCAAGAGACCTCGTGG	PDPK1	ENSG00000140992	-4.412097752607405	[265,207]	[0,17,19]	-9	hSpCas9	negative selection	5011023
2581685	2581707	16	-	27760321	HT29	viability after 22 days	TACCAAAAGTTTCTCCACGAGG	PDPK1	ENSG00000140992	-0.23137320278672746	[0,0]	[0,0,0]	-2	hSpCas9	negative selection	5011024
2581301	2581323	16	-	27760321	HT29	viability after 19 days	TATGCATCCAAGAGCCCAAAGG	PDPK1	ENSG00000140992	-7.210862637207343	[293,229]	[0,3,0]	-9	hSpCas9	negative selection	5094484
2581343	2581365	16	+	27760321	HT29	viability after 19 days	ACTCCCACCATTCCGAGCTGGG	PDPK1	ENSG00000140992	-2.5400992719243485	[1010,788]	[79,192,244]	-8	hSpCas9	negative selection	5094485
2581671	2581693	16	+	27760321	HT29	viability after 19 days	CCTAAGGCAAGAGACCTCGTGG	PDPK1	ENSG00000140992	-3.495396810068483	[265,207]	[35,3,32]	-9	hSpCas9	negative selection	5094486
2581685	2581707	16	-	27760321	HT29	viability after 19 days	TACCAAAAGTTTCTCCACGAGG	PDPK1	ENSG00000140992	-0.21553315036351428	[0,0]	[0,0,0]	-2	hSpCas9	negative selection	5094487
2581301	2581323	16	-	27760321	HT29	viability after 16 days	TATGCATCCAAGAGCCCAAAGG	PDPK1	ENSG00000140992	-3.0596243880856164	[293,229]	[21,5,76]	-9	hSpCas9	negative selection	5177947
2581343	2581365	16	+	27760321	HT29	viability after 16 days	ACTCCCACCATTCCGAGCTGGG	PDPK1	ENSG00000140992	-2.805028558860007	[1010,788]	[156,83,193]	-9	hSpCas9	negative selection	5177948
2581671	2581693	16	+	27760321	HT29	viability after 16 days	CCTAAGGCAAGAGACCTCGTGG	PDPK1	ENSG00000140992	-3.0808461889702574	[265,207]	[35,48,8]	-9	hSpCas9	negative selection	5177949
2581685	2581707	16	-	27760321	HT29	viability after 16 days	TACCAAAAGTTTCTCCACGAGG	PDPK1	ENSG00000140992	-0.1840686979425925	[0,0]	[0,0,0]	-2	hSpCas9	negative selection	5177950
2581301	2581323	16	-	27760321	HT29	viability after 13 days	TATGCATCCAAGAGCCCAAAGG	PDPK1	ENSG00000140992	-1.8652955497320223	[293,229]	[60,82,104]	-8	hSpCas9	negative selection	5261410
2581343	2581365	16	+	27760321	HT29	viability after 13 days	ACTCCCACCATTCCGAGCTGGG	PDPK1	ENSG00000140992	-1.8276609473048384	[1010,788]	[141,365,369]	-8	hSpCas9	negative selection	5261411
2581671	2581693	16	+	27760321	HT29	viability after 13 days	CCTAAGGCAAGAGACCTCGTGG	PDPK1	ENSG00000140992	-1.9479834978353774	[265,207]	[14,145,53]	-8	hSpCas9	negative selection	5261412
2581685	2581707	16	-	27760321	HT29	viability after 13 days	TACCAAAAGTTTCTCCACGAGG	PDPK1	ENSG00000140992	-0.23635609738673047	[0,0]	[0,0,0]	-3	hSpCas9	negative selection	5261413
2581301	2581323	16	-	27760321	HT29	viability after 10 days	TATGCATCCAAGAGCCCAAAGG	PDPK1	ENSG00000140992	-0.9111221147512791	[293,229]	[253,139,127]	-7	hSpCas9	negative selection	5344873
2581343	2581365	16	+	27760321	HT29	viability after 10 days	ACTCCCACCATTCCGAGCTGGG	PDPK1	ENSG00000140992	-0.9655776426549989	[1010,788]	[817,503,405]	-7	hSpCas9	negative selection	5344874
2581671	2581693	16	+	27760321	HT29	viability after 10 days	CCTAAGGCAAGAGACCTCGTGG	PDPK1	ENSG00000140992	-1.0515880757871907	[265,207]	[92,118,213]	-8	hSpCas9	negative selection	5344875
2581685	2581707	16	-	27760321	HT29	viability after 10 days	TACCAAAAGTTTCTCCACGAGG	PDPK1	ENSG00000140992	-0.34236740454707437	[0,0]	[0,0,0]	-4	hSpCas9	negative selection	5344876
2581301	2581323	16	-	27760321	MOLM13	viability	TATGCATCCAAGAGCCCAAAGG	PDPK1	ENSG00000140992	-2.0958947183291348	[353,293]	[54,31]	-8	hSpCas9	negative selection	5428336
2581343	2581365	16	+	27760321	MOLM13	viability	ACTCCCACCATTCCGAGCTGGG	PDPK1	ENSG00000140992	-2.334719430756933	[1173,1010]	[49,182]	-8	hSpCas9	negative selection	5428337
2581671	2581693	16	+	27760321	MOLM13	viability	CCTAAGGCAAGAGACCTCGTGG	PDPK1	ENSG00000140992	-3.959053581786377	[295,265]	[0,17]	-9	hSpCas9	negative selection	5428338
2581685	2581707	16	-	27760321	MOLM13	viability	TACCAAAAGTTTCTCCACGAGG	PDPK1	ENSG00000140992	0.8210053139495912	[0,0]	[0,0]	6	hSpCas9	negative selection	5428339
2538008	2538031	16	+	27661255	K562	viability	GATGAGGGCGGCCATTGCTGGGG	PDPK1	ENSG00000140992	-1.3903758604703538	[788,1089]	[336,239]	-9	dCas9-KRAB	negative selection	5501071
2538024	2538047	16	+	27661255	K562	viability	GCTGGGGCTCCGCTTCGGGGAGG	PDPK1	ENSG00000140992	-1.6036622741436934	[630,647]	[194,144]	-9	dCas9-KRAB	negative selection	5501072
2538165	2538188	16	-	27661255	K562	viability	GACCCGGCAGGGTAACAAACCGG	PDPK1	ENSG00000140992	-0.4023475744012721	[99,131]	[72,66]	-7	dCas9-KRAB	negative selection	5501073
2581622	2581645	16	+	27260156	BXPC3	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.13229783950307142	[604]	[509,643,508,652]	-3	hSpCas9	negative selection	5626294
2581622	2581645	16	+	27260156	A673	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.2327374558120226	[604]	[555,573,682,653]	-5	hSpCas9	negative selection	5747545
2581622	2581645	16	+	27260156	A375	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-1.0820889029828704	[604]	[344,314,371,302]	-8	hSpCas9	negative selection	5868796
2581622	2581645	16	+	27260156	COLO741	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.08054262491044828	[604]	[699,786,703]	-2	hSpCas9	negative selection	5990047
2581622	2581645	16	+	27260156	CAL120	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.8468782511487832	[604]	[586,336,357]	-8	hSpCas9	negative selection	6111298
2581622	2581645	16	+	27260156	CADOES1	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.26050233416669183	[604]	[349,580,540,404]	-4	hSpCas9	negative selection	6232549
2581622	2581645	16	+	27260156	EWS502	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.4474316229866132	[604]	[522,333,488,535]	-6	hSpCas9	negative selection	6353800
2581622	2581645	16	+	27260156	EW8	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.3411015547700944	[604]	[531,387,305,350]	-6	hSpCas9	negative selection	6475051
2581622	2581645	16	+	27260156	CORL105	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.7693924291961876	[604]	[286,347,527,512]	-8	hSpCas9	negative selection	6596302
2581622	2581645	16	+	27260156	HS294T	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.47080203777420415	[604]	[135,129,199,221]	-6	hSpCas9	negative selection	6717553
2581622	2581645	16	+	27260156	HCC44	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.28913383093899664	[604]	[742,448,733,377]	-4	hSpCas9	negative selection	6838804
2581622	2581645	16	+	27260156	G402	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.4201535767928511	[604]	[610,657,410,539]	-5	hSpCas9	negative selection	6960055
2581622	2581645	16	+	27260156	L33	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	0.03366177645502971	[604]	[607,292,339,612]	0	hSpCas9	negative selection	7081306
2581622	2581645	16	+	27260156	K562	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	0.3884844911593638	[604]	[574,516,898,786]	5	hSpCas9	negative selection	7202557
2581622	2581645	16	+	27260156	HT29	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.6261017122549319	[604]	[620,469,523,317]	-8	hSpCas9	negative selection	7323808
2581622	2581645	16	+	27260156	MHHES1	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.5541273854596916	[604]	[511,443,595,329]	-8	hSpCas9	negative selection	7445059
2581622	2581645	16	+	27260156	MEWO	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	0.1837132497716566	[604]	[686,652,596]	4	hSpCas9	negative selection	7566310
2581622	2581645	16	+	27260156	LNCAPCLONEFGC	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.696359245954184	[604]	[329,320,358,346]	-8	hSpCas9	negative selection	7687561
2581622	2581645	16	+	27260156	PANC0327	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	0.058099908232194575	[604]	[713,354,607,599]	0	hSpCas9	negative selection	7808812
2581622	2581645	16	+	27260156	NCIH2009	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-1.1110449797709874	[604]	[434,443,301]	-8	hSpCas9	negative selection	7930063
2581622	2581645	16	+	27260156	NCIH1373	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.7772488294159657	[604]	[590,357,321,89]	-7	hSpCas9	negative selection	8051314
2581622	2581645	16	+	27260156	PATU8902	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-3.348002072425909	[604]	[142,104,8,92]	-9	hSpCas9	negative selection	8172565
2581622	2581645	16	+	27260156	PANC1	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.5913486083281202	[604]	[485,268,344,267]	-7	hSpCas9	negative selection	8293816
2581622	2581645	16	+	27260156	PANC0813	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.7427694928943017	[604]	[703,363,316,342]	-8	hSpCas9	negative selection	8415067
2581622	2581645	16	+	27260156	RDES	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.7659227356699393	[604]	[355,399,387,505]	-8	hSpCas9	negative selection	8536318
2581622	2581645	16	+	27260156	PC3	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	0.3961852143830653	[604]	[567,711,1568,637]	8	hSpCas9	negative selection	8657569
2581622	2581645	16	+	27260156	PATU8988T	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.7216487610836132	[604]	[301,432,243,455]	-8	hSpCas9	negative selection	8778820
2581622	2581645	16	+	27260156	T47D	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	0.09232096265355799	[604]	[740,752,718,793]	2	hSpCas9	negative selection	8900071
2581622	2581645	16	+	27260156	SU8686	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.15823079753033908	[604]	[573,585,413,561]	-3	hSpCas9	negative selection	9021322
2581622	2581645	16	+	27260156	SKES1	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.011047869631394813	[604]	[577,613,709,496]	0	hSpCas9	negative selection	9142573
2581622	2581645	16	+	27260156	TOV112D	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	0.1308017084597583	[604]	[585,746,571,758]	2	hSpCas9	negative selection	9263824
2581622	2581645	16	+	27260156	TC71	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	0.24468943506432872	[604]	[743,834,701,796]	6	hSpCas9	negative selection	9385075
2581622	2581645	16	+	27260156	TC32	viability	ATTTCAGAAGATCATTAAGTTGG	PDPK1	ENSG00000140992	-0.3549585855002881	[604]	[480,345,564,409]	-6	hSpCas9	negative selection	9506326
2586807	2586830	16	+	27869803	HPAFII	viability after 27 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	0.038327519883242345	[375]	[238,172,NaN]	0	hSpCas9	negative selection	9556356
2595829	2595852	16	+	27869803	HPAFII	viability after 27 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-2.755891438479524	[145]	[0,19,NaN]	-9	hSpCas9	negative selection	9556357
2597216	2597239	16	-	27869803	HPAFII	viability after 27 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	0.3346329696712413	[139]	[100,85,NaN]	2	hSpCas9	negative selection	9556358
2597679	2597702	16	-	27869803	HPAFII	viability after 27 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	-0.24929730770837577	[155]	[122,23,NaN]	-2	hSpCas9	negative selection	9556359
2597728	2597751	16	+	27869803	HPAFII	viability after 27 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	0.044272039410769515	[190]	[24,168,NaN]	0	hSpCas9	negative selection	9556360
2586807	2586830	16	+	27869803	HPAFII	viability after 15 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	0.45077379521653915	[375]	[666,480,NaN]	5	hSpCas9	negative selection	9638805
2595829	2595852	16	+	27869803	HPAFII	viability after 15 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-1.5985152074942843	[145]	[28,65,NaN]	-8	hSpCas9	negative selection	9638806
2597216	2597239	16	-	27869803	HPAFII	viability after 15 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	0.7680663413041281	[139]	[447,136,NaN]	8	hSpCas9	negative selection	9638807
2597679	2597702	16	-	27869803	HPAFII	viability after 15 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	1.1787138975689064	[155]	[574,257,NaN]	9	hSpCas9	negative selection	9638808
2597728	2597751	16	+	27869803	HPAFII	viability after 15 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	-0.3695946344398502	[190]	[140,169,NaN]	-4	hSpCas9	negative selection	9638809
2586807	2586830	16	+	27869803	ASPC1	viability after 36 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	0.4145859274832375	[984]	[416,439,496]	4	hSpCas9	negative selection	9721254
2595829	2595852	16	+	27869803	ASPC1	viability after 36 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-1.9862044033001491	[351]	[21,59,13]	-9	hSpCas9	negative selection	9721255
2597216	2597239	16	-	27869803	ASPC1	viability after 36 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	-0.08495789827485922	[392]	[198,131,76]	-1	hSpCas9	negative selection	9721256
2597679	2597702	16	-	27869803	ASPC1	viability after 36 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	-0.9235762460118381	[633]	[114,56,163]	-7	hSpCas9	negative selection	9721257
2597728	2597751	16	+	27869803	ASPC1	viability after 36 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	-0.08257046893498621	[470]	[191,76,189]	-1	hSpCas9	negative selection	9721258
2586807	2586830	16	+	27869803	PATU8988S	viability after 35 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-1.1757185210322134	[837]	[105,192,NaN]	-8	hSpCas9	negative selection	9803703
2595829	2595852	16	+	27869803	PATU8988S	viability after 35 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-2.7389334826583074	[298]	[34,0,NaN]	-9	hSpCas9	negative selection	9803704
2597216	2597239	16	-	27869803	PATU8988S	viability after 35 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	-0.9156054618356764	[350]	[48,100,NaN]	-7	hSpCas9	negative selection	9803705
2597679	2597702	16	-	27869803	PATU8988S	viability after 35 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	-1.6175388639691395	[441]	[63,51,NaN]	-8	hSpCas9	negative selection	9803706
2597728	2597751	16	+	27869803	PATU8988S	viability after 35 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	0.12343440353080593	[307]	[190,78,NaN]	1	hSpCas9	negative selection	9803707
2586807	2586830	16	+	27869803	PATU8988S	viability after 31 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-0.48136603019786073	[837]	[186,305,NaN]	-5	hSpCas9	negative selection	9886152
2595829	2595852	16	+	27869803	PATU8988S	viability after 31 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-2.371414556090308	[298]	[26,17,NaN]	-9	hSpCas9	negative selection	9886153
2597216	2597239	16	-	27869803	PATU8988S	viability after 31 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	-1.0533778474722963	[350]	[55,81,NaN]	-8	hSpCas9	negative selection	9886154
2597679	2597702	16	-	27869803	PATU8988S	viability after 31 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	-0.05618775652555413	[441]	[132,215,NaN]	0	hSpCas9	negative selection	9886155
2597728	2597751	16	+	27869803	PATU8988S	viability after 31 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	-0.25948344568184056	[307]	[84,124,NaN]	-3	hSpCas9	negative selection	9886156
2586807	2586830	16	+	27869803	HPAFII	viability after 35 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	0.07551261403661325	[375]	[296,91,NaN]	0	hSpCas9	negative selection	9968601
2595829	2595852	16	+	27869803	HPAFII	viability after 35 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-1.4101898131056911	[145]	[0,57,NaN]	-6	hSpCas9	negative selection	9968602
2597216	2597239	16	-	27869803	HPAFII	viability after 35 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	0.45981414280012245	[139]	[112,79,NaN]	3	hSpCas9	negative selection	9968603
2597679	2597702	16	-	27869803	HPAFII	viability after 35 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	-1.1210861723389396	[155]	[64,3,NaN]	-6	hSpCas9	negative selection	9968604
2597728	2597751	16	+	27869803	HPAFII	viability after 35 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	-0.44142281841923126	[190]	[10,138,NaN]	-3	hSpCas9	negative selection	9968605
2586807	2586830	16	+	27869803	HPAFII	viability after 31 days	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-0.02603908374987063	[375]	[234,176,NaN]	0	hSpCas9	negative selection	10051050
2595829	2595852	16	+	27869803	HPAFII	viability after 31 days	GGGCCCAGTGGATAAGCGGAAGG	PDPK1	ENSG00000140992	-2.094492786722283	[145]	[0,38,NaN]	-8	hSpCas9	negative selection	10051051
2597216	2597239	16	-	27869803	HPAFII	viability after 31 days	GGTCGAAGTTCTTGTGACCAAGG	PDPK1	ENSG00000140992	0.8843525725970126	[139]	[156,131,NaN]	6	hSpCas9	negative selection	10051052
2597679	2597702	16	-	27869803	HPAFII	viability after 31 days	CCACTTGTGTGCGTTCCCGCTGG	PDPK1	ENSG00000140992	-0.024329078537493998	[155]	[154,10,NaN]	0	hSpCas9	negative selection	10051053
2597728	2597751	16	+	27869803	HPAFII	viability after 31 days	GCAGCGATACCAGAGCCACCCGG	PDPK1	ENSG00000140992	-1.0247177048761196	[190]	[0,108,NaN]	-6	hSpCas9	negative selection	10051054
2586722	2586745	16	-	28162770	P31FUJ	viability	TGACAGGGAGTGTGAGGAGGAGG	PDPK1	ENSG00000140992	-0.7292280305338776	[78]	[55]	-5	hSpCas9	negative selection	10209172
2538115	2538138	16	+	28162770	P31FUJ	viability	GGCCAGGACCACCAGCCAGCTGG	PDPK1	ENSG00000140992	0.26402938602811266	[179]	[253]	3	hSpCas9	negative selection	10209173
2586807	2586830	16	+	28162770	P31FUJ	viability	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-1.2328022044143783	[31]	[15]	-7	hSpCas9	negative selection	10209174
2586862	2586885	16	+	28162770	P31FUJ	viability	TTGTTGGAGAAGCAGGCTGGCGG	PDPK1	ENSG00000140992	-1.1258870004978667	[25]	[13]	-7	hSpCas9	negative selection	10209175
2538123	2538146	16	-	28162770	P31FUJ	viability	CGCGCTCACCAGCTGGCTGGTGG	PDPK1	ENSG00000140992	0.09767099960599256	[201]	[253]	1	hSpCas9	negative selection	10209176
2586687	2586710	16	-	28162770	P31FUJ	viability	GCATGCAGCCAAACTGGCTCAGG	PDPK1	ENSG00000140992	-1.1821761313444106	[111]	[57]	-7	hSpCas9	negative selection	10209177
2586763	2586786	16	-	28162770	P31FUJ	viability	ATGTTGCTGCCTGACCTCTGGGG	PDPK1	ENSG00000140992	-1.6041183262639045	[519]	[200]	-7	hSpCas9	negative selection	10209178
2586872	2586895	16	+	28162770	P31FUJ	viability	AGCAGGCTGGCGGAAACCCTTGG	PDPK1	ENSG00000140992	-2.800486713703699	[414]	[69]	-9	hSpCas9	negative selection	10209179
2557924	2557947	16	+	28162770	P31FUJ	viability	CAAGTTTGGGAAAATCCTTGGGG	PDPK1	ENSG00000140992	0.09321284799622664	[563]	[706]	0	hSpCas9	negative selection	10209180
2586836	2586859	16	+	28162770	P31FUJ	viability	AGTTTTCCGAAGATGAGAAGAGG	PDPK1	ENSG00000140992	-1.945362485912307	[507]	[154]	-8	hSpCas9	negative selection	10209181
2586722	2586745	16	-	28162770	TF1	viability	TGACAGGGAGTGTGAGGAGGAGG	PDPK1	ENSG00000140992	NaN	[NaN]	[15]	1	hSpCas9	negative selection	10378538
2538115	2538138	16	+	28162770	TF1	viability	GGCCAGGACCACCAGCCAGCTGG	PDPK1	ENSG00000140992	NaN	[NaN]	[135]	1	hSpCas9	negative selection	10378539
2586807	2586830	16	+	28162770	TF1	viability	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	NaN	[NaN]	[1]	1	hSpCas9	negative selection	10378540
2586862	2586885	16	+	28162770	TF1	viability	TTGTTGGAGAAGCAGGCTGGCGG	PDPK1	ENSG00000140992	NaN	[NaN]	[0]	1	hSpCas9	negative selection	10378541
2538123	2538146	16	-	28162770	TF1	viability	CGCGCTCACCAGCTGGCTGGTGG	PDPK1	ENSG00000140992	NaN	[NaN]	[92]	1	hSpCas9	negative selection	10378542
2586687	2586710	16	-	28162770	TF1	viability	GCATGCAGCCAAACTGGCTCAGG	PDPK1	ENSG00000140992	NaN	[NaN]	[98]	1	hSpCas9	negative selection	10378543
2586763	2586786	16	-	28162770	TF1	viability	ATGTTGCTGCCTGACCTCTGGGG	PDPK1	ENSG00000140992	NaN	[NaN]	[221]	1	hSpCas9	negative selection	10378544
2586872	2586895	16	+	28162770	TF1	viability	AGCAGGCTGGCGGAAACCCTTGG	PDPK1	ENSG00000140992	NaN	[NaN]	[197]	1	hSpCas9	negative selection	10378545
2557924	2557947	16	+	28162770	TF1	viability	CAAGTTTGGGAAAATCCTTGGGG	PDPK1	ENSG00000140992	NaN	[NaN]	[463]	1	hSpCas9	negative selection	10378546
2586836	2586859	16	+	28162770	TF1	viability	AGTTTTCCGAAGATGAGAAGAGG	PDPK1	ENSG00000140992	NaN	[NaN]	[324]	1	hSpCas9	negative selection	10378547
2586722	2586745	16	-	28162770	SKM1	viability	TGACAGGGAGTGTGAGGAGGAGG	PDPK1	ENSG00000140992	-1.2814333166593026	[21]	[15]	-7	hSpCas9	negative selection	10547904
2538115	2538138	16	+	28162770	SKM1	viability	GGCCAGGACCACCAGCCAGCTGG	PDPK1	ENSG00000140992	-0.05417514015103875	[36]	[62]	0	hSpCas9	negative selection	10547905
2586807	2586830	16	+	28162770	SKM1	viability	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-1.5000736031346436	[7]	[4]	-7	hSpCas9	negative selection	10547906
2586862	2586885	16	+	28162770	SKM1	viability	TTGTTGGAGAAGCAGGCTGGCGG	PDPK1	ENSG00000140992	-2.2814333166593026	[10]	[3]	-8	hSpCas9	negative selection	10547907
2538123	2538146	16	-	28162770	SKM1	viability	CGCGCTCACCAGCTGGCTGGTGG	PDPK1	ENSG00000140992	0.43876253418696126	[52]	[126]	4	hSpCas9	negative selection	10547908
2586687	2586710	16	-	28162770	SKM1	viability	GCATGCAGCCAAACTGGCTCAGG	PDPK1	ENSG00000140992	0.5873892381156962	[31]	[84]	5	hSpCas9	negative selection	10547909
2586763	2586786	16	-	28162770	SKM1	viability	ATGTTGCTGCCTGACCTCTGGGG	PDPK1	ENSG00000140992	-1.9680799575099501	[134]	[60]	-8	hSpCas9	negative selection	10547910
2586872	2586895	16	+	28162770	SKM1	viability	AGCAGGCTGGCGGAAACCCTTGG	PDPK1	ENSG00000140992	-1.0813883268406552	[78]	[65]	-7	hSpCas9	negative selection	10547911
2557924	2557947	16	+	28162770	SKM1	viability	CAAGTTTGGGAAAATCCTTGGGG	PDPK1	ENSG00000140992	-0.026142414802231118	[143]	[249]	0	hSpCas9	negative selection	10547912
2586836	2586859	16	+	28162770	SKM1	viability	AGTTTTCCGAAGATGAGAAGAGG	PDPK1	ENSG00000140992	-2.677053362110906	[122]	[33]	-9	hSpCas9	negative selection	10547913
2586722	2586745	16	-	28162770	SKM1	viability	TGACAGGGAGTGTGAGGAGGAGG	PDPK1	ENSG00000140992	-1.2814333166593026	[21]	[15]	-7	hSpCas9	negative selection	10717270
2538115	2538138	16	+	28162770	SKM1	viability	GGCCAGGACCACCAGCCAGCTGG	PDPK1	ENSG00000140992	-0.05417514015103875	[36]	[62]	0	hSpCas9	negative selection	10717271
2586807	2586830	16	+	28162770	SKM1	viability	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-1.5000736031346436	[7]	[4]	-7	hSpCas9	negative selection	10717272
2586862	2586885	16	+	28162770	SKM1	viability	TTGTTGGAGAAGCAGGCTGGCGG	PDPK1	ENSG00000140992	-2.2814333166593026	[10]	[3]	-8	hSpCas9	negative selection	10717273
2538123	2538146	16	-	28162770	SKM1	viability	CGCGCTCACCAGCTGGCTGGTGG	PDPK1	ENSG00000140992	0.43876253418696126	[52]	[126]	4	hSpCas9	negative selection	10717274
2586687	2586710	16	-	28162770	SKM1	viability	GCATGCAGCCAAACTGGCTCAGG	PDPK1	ENSG00000140992	0.5873892381156962	[31]	[84]	5	hSpCas9	negative selection	10717275
2586763	2586786	16	-	28162770	SKM1	viability	ATGTTGCTGCCTGACCTCTGGGG	PDPK1	ENSG00000140992	-1.9680799575099501	[134]	[60]	-8	hSpCas9	negative selection	10717276
2586872	2586895	16	+	28162770	SKM1	viability	AGCAGGCTGGCGGAAACCCTTGG	PDPK1	ENSG00000140992	-1.0813883268406552	[78]	[65]	-7	hSpCas9	negative selection	10717277
2557924	2557947	16	+	28162770	SKM1	viability	CAAGTTTGGGAAAATCCTTGGGG	PDPK1	ENSG00000140992	-0.026142414802231118	[143]	[249]	0	hSpCas9	negative selection	10717278
2586836	2586859	16	+	28162770	SKM1	viability	AGTTTTCCGAAGATGAGAAGAGG	PDPK1	ENSG00000140992	-2.677053362110906	[122]	[33]	-9	hSpCas9	negative selection	10717279
2586722	2586745	16	-	28162770	PL21	viability	TGACAGGGAGTGTGAGGAGGAGG	PDPK1	ENSG00000140992	-0.21489788478952354	[71]	[26]	-1	hSpCas9	negative selection	10886636
2538115	2538138	16	+	28162770	PL21	viability	GGCCAGGACCACCAGCCAGCTGG	PDPK1	ENSG00000140992	-0.8587540745642483	[124]	[29]	-5	hSpCas9	negative selection	10886637
2586807	2586830	16	+	28162770	PL21	viability	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	0.24594330410244503	[30]	[15]	2	hSpCas9	negative selection	10886638
2586862	2586885	16	+	28162770	PL21	viability	TTGTTGGAGAAGCAGGCTGGCGG	PDPK1	ENSG00000140992	-2.3023607260398635	[33]	[2]	-8	hSpCas9	negative selection	10886639
2538123	2538146	16	-	28162770	PL21	viability	CGCGCTCACCAGCTGGCTGGTGG	PDPK1	ENSG00000140992	-0.7613862376960442	[221]	[56]	-5	hSpCas9	negative selection	10886640
2586687	2586710	16	-	28162770	PL21	viability	GCATGCAGCCAAACTGGCTCAGG	PDPK1	ENSG00000140992	-0.3234223415676929	[91]	[31]	-2	hSpCas9	negative selection	10886641
2586763	2586786	16	-	28162770	PL21	viability	ATGTTGCTGCCTGACCTCTGGGG	PDPK1	ENSG00000140992	-1.5281870614030133	[443]	[66]	-7	hSpCas9	negative selection	10886642
2586872	2586895	16	+	28162770	PL21	viability	AGCAGGCTGGCGGAAACCCTTGG	PDPK1	ENSG00000140992	-1.6338504340717506	[327]	[45]	-8	hSpCas9	negative selection	10886643
2557924	2557947	16	+	28162770	PL21	viability	CAAGTTTGGGAAAATCCTTGGGG	PDPK1	ENSG00000140992	0.08692900404132953	[423]	[195]	0	hSpCas9	negative selection	10886644
2586836	2586859	16	+	28162770	PL21	viability	AGTTTTCCGAAGATGAGAAGAGG	PDPK1	ENSG00000140992	-0.34042876687338264	[351]	[120]	-2	hSpCas9	negative selection	10886645
2586722	2586745	16	-	28162770	P31FUJ	viability	TGACAGGGAGTGTGAGGAGGAGG	PDPK1	ENSG00000140992	-0.7292280305338776	[78]	[55]	-5	hSpCas9	negative selection	11056002
2538115	2538138	16	+	28162770	P31FUJ	viability	GGCCAGGACCACCAGCCAGCTGG	PDPK1	ENSG00000140992	0.26402938602811266	[179]	[253]	3	hSpCas9	negative selection	11056003
2586807	2586830	16	+	28162770	P31FUJ	viability	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-1.2328022044143783	[31]	[15]	-7	hSpCas9	negative selection	11056004
2586862	2586885	16	+	28162770	P31FUJ	viability	TTGTTGGAGAAGCAGGCTGGCGG	PDPK1	ENSG00000140992	-1.1258870004978667	[25]	[13]	-7	hSpCas9	negative selection	11056005
2538123	2538146	16	-	28162770	P31FUJ	viability	CGCGCTCACCAGCTGGCTGGTGG	PDPK1	ENSG00000140992	0.09767099960599256	[201]	[253]	1	hSpCas9	negative selection	11056006
2586687	2586710	16	-	28162770	P31FUJ	viability	GCATGCAGCCAAACTGGCTCAGG	PDPK1	ENSG00000140992	-1.1821761313444106	[111]	[57]	-7	hSpCas9	negative selection	11056007
2586763	2586786	16	-	28162770	P31FUJ	viability	ATGTTGCTGCCTGACCTCTGGGG	PDPK1	ENSG00000140992	-1.6041183262639045	[519]	[200]	-7	hSpCas9	negative selection	11056008
2586872	2586895	16	+	28162770	P31FUJ	viability	AGCAGGCTGGCGGAAACCCTTGG	PDPK1	ENSG00000140992	-2.800486713703699	[414]	[69]	-9	hSpCas9	negative selection	11056009
2557924	2557947	16	+	28162770	P31FUJ	viability	CAAGTTTGGGAAAATCCTTGGGG	PDPK1	ENSG00000140992	0.09321284799622664	[563]	[706]	0	hSpCas9	negative selection	11056010
2586836	2586859	16	+	28162770	P31FUJ	viability	AGTTTTCCGAAGATGAGAAGAGG	PDPK1	ENSG00000140992	-1.945362485912307	[507]	[154]	-8	hSpCas9	negative selection	11056011
2586722	2586745	16	-	28162770	OCIAML5	viability	TGACAGGGAGTGTGAGGAGGAGG	PDPK1	ENSG00000140992	-2.9026926439339644	[28]	[6]	-8	hSpCas9	negative selection	11225368
2538115	2538138	16	+	28162770	OCIAML5	viability	GGCCAGGACCACCAGCCAGCTGG	PDPK1	ENSG00000140992	-1.0393451390565773	[114]	[100]	-6	hSpCas9	negative selection	11225369
2586807	2586830	16	+	28162770	OCIAML5	viability	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-0.4114939794780157	[27]	[37]	-3	hSpCas9	negative selection	11225370
2586862	2586885	16	+	28162770	OCIAML5	viability	TTGTTGGAGAAGCAGGCTGGCGG	PDPK1	ENSG00000140992	1.294774817465274	[6]	[30]	9	hSpCas9	negative selection	11225371
2538123	2538146	16	-	28162770	OCIAML5	viability	CGCGCTCACCAGCTGGCTGGTGG	PDPK1	ENSG00000140992	1.0633212014210618	[78]	[297]	8	hSpCas9	negative selection	11225372
2586687	2586710	16	-	28162770	OCIAML5	viability	GCATGCAGCCAAACTGGCTCAGG	PDPK1	ENSG00000140992	-3.489496491479289	[55]	[8]	-9	hSpCas9	negative selection	11225373
2586763	2586786	16	-	28162770	OCIAML5	viability	ATGTTGCTGCCTGACCTCTGGGG	PDPK1	ENSG00000140992	-0.2878626303096382	[279]	[413]	-2	hSpCas9	negative selection	11225374
2586872	2586895	16	+	28162770	OCIAML5	viability	AGCAGGCTGGCGGAAACCCTTGG	PDPK1	ENSG00000140992	-0.9297191265164615	[228]	[216]	-5	hSpCas9	negative selection	11225375
2557924	2557947	16	+	28162770	OCIAML5	viability	CAAGTTTGGGAAAATCCTTGGGG	PDPK1	ENSG00000140992	1.1430731380454682	[222]	[888]	8	hSpCas9	negative selection	11225376
2586836	2586859	16	+	28162770	OCIAML5	viability	AGTTTTCCGAAGATGAGAAGAGG	PDPK1	ENSG00000140992	0.06876321570239519	[308]	[584]	0	hSpCas9	negative selection	11225377
2586722	2586745	16	-	28162770	EOL1	viability	TGACAGGGAGTGTGAGGAGGAGG	PDPK1	ENSG00000140992	-1.9083422425942071	[113]	[15]	-8	hSpCas9	negative selection	11394734
2538115	2538138	16	+	28162770	EOL1	viability	GGCCAGGACCACCAGCCAGCTGG	PDPK1	ENSG00000140992	0.15195826767360726	[204]	[119]	1	hSpCas9	negative selection	11394735
2586807	2586830	16	+	28162770	EOL1	viability	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-3.0296485388163408	[61]	[3]	-9	hSpCas9	negative selection	11394736
2586862	2586885	16	+	28162770	EOL1	viability	TTGTTGGAGAAGCAGGCTGGCGG	PDPK1	ENSG00000140992	-3.0754522284294654	[31]	[1]	-9	hSpCas9	negative selection	11394737
2538123	2538146	16	-	28162770	EOL1	viability	CGCGCTCACCAGCTGGCTGGTGG	PDPK1	ENSG00000140992	0.04127137787221713	[355]	[192]	0	hSpCas9	negative selection	11394738
2586687	2586710	16	-	28162770	EOL1	viability	GCATGCAGCCAAACTGGCTCAGG	PDPK1	ENSG00000140992	-0.8409869747924423	[203]	[59]	-5	hSpCas9	negative selection	11394739
2586763	2586786	16	-	28162770	EOL1	viability	ATGTTGCTGCCTGACCTCTGGGG	PDPK1	ENSG00000140992	-1.0491409513136183	[651]	[165]	-6	hSpCas9	negative selection	11394740
2586872	2586895	16	+	28162770	EOL1	viability	AGCAGGCTGGCGGAAACCCTTGG	PDPK1	ENSG00000140992	-1.9749253524755008	[484]	[64]	-8	hSpCas9	negative selection	11394741
2557924	2557947	16	+	28162770	EOL1	viability	CAAGTTTGGGAAAATCCTTGGGG	PDPK1	ENSG00000140992	0.854538050322792	[569]	[542]	7	hSpCas9	negative selection	11394742
2586836	2586859	16	+	28162770	EOL1	viability	AGTTTTCCGAAGATGAGAAGAGG	PDPK1	ENSG00000140992	-1.3008723424634816	[476]	[101]	-7	hSpCas9	negative selection	11394743
2586722	2586745	16	-	28162770	MOLM13	viability	TGACAGGGAGTGTGAGGAGGAGG	PDPK1	ENSG00000140992	0.12549718409750077	[70]	[55]	0	hSpCas9	negative selection	11564100
2538115	2538138	16	+	28162770	MOLM13	viability	GGCCAGGACCACCAGCCAGCTGG	PDPK1	ENSG00000140992	0.45278248915437047	[191]	[189]	3	hSpCas9	negative selection	11564101
2586807	2586830	16	+	28162770	MOLM13	viability	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-1.0060418067878334	[74]	[26]	-5	hSpCas9	negative selection	11564102
2586862	2586885	16	+	28162770	MOLM13	viability	TTGTTGGAGAAGCAGGCTGGCGG	PDPK1	ENSG00000140992	3.3122385110843844	[10]	[78]	9	hSpCas9	negative selection	11564103
2538123	2538146	16	-	28162770	MOLM13	viability	CGCGCTCACCAGCTGGCTGGTGG	PDPK1	ENSG00000140992	1.20832716761759	[248]	[415]	8	hSpCas9	negative selection	11564104
2586687	2586710	16	-	28162770	MOLM13	viability	GCATGCAGCCAAACTGGCTCAGG	PDPK1	ENSG00000140992	1.2537645761917315	[115]	[199]	8	hSpCas9	negative selection	11564105
2586763	2586786	16	-	28162770	MOLM13	viability	ATGTTGCTGCCTGACCTCTGGGG	PDPK1	ENSG00000140992	-2.0630954981177525	[681]	[117]	-7	hSpCas9	negative selection	11564106
2586872	2586895	16	+	28162770	MOLM13	viability	AGCAGGCTGGCGGAAACCCTTGG	PDPK1	ENSG00000140992	-2.513202155905357	[378]	[47]	-8	hSpCas9	negative selection	11564107
2557924	2557947	16	+	28162770	MOLM13	viability	CAAGTTTGGGAAAATCCTTGGGG	PDPK1	ENSG00000140992	0.3592888954105973	[592]	[549]	2	hSpCas9	negative selection	11564108
2586836	2586859	16	+	28162770	MOLM13	viability	AGTTTTCCGAAGATGAGAAGAGG	PDPK1	ENSG00000140992	-2.0263076552533947	[692]	[122]	-7	hSpCas9	negative selection	11564109
2586722	2586745	16	-	28162770	HEL	viability	TGACAGGGAGTGTGAGGAGGAGG	PDPK1	ENSG00000140992	-0.5416857391370704	[99]	[43]	-4	hSpCas9	negative selection	11733466
2538115	2538138	16	+	28162770	HEL	viability	GGCCAGGACCACCAGCCAGCTGG	PDPK1	ENSG00000140992	0.6012195625620903	[140]	[136]	5	hSpCas9	negative selection	11733467
2586807	2586830	16	+	28162770	HEL	viability	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	0.3899727616203903	[55]	[46]	3	hSpCas9	negative selection	11733468
2586862	2586885	16	+	28162770	HEL	viability	TTGTTGGAGAAGCAGGCTGGCGG	PDPK1	ENSG00000140992	1.490735738555307	[19]	[35]	9	hSpCas9	negative selection	11733469
2538123	2538146	16	-	28162770	HEL	viability	CGCGCTCACCAGCTGGCTGGTGG	PDPK1	ENSG00000140992	0.12248202066701602	[217]	[151]	1	hSpCas9	negative selection	11733470
2586687	2586710	16	-	28162770	HEL	viability	GCATGCAGCCAAACTGGCTCAGG	PDPK1	ENSG00000140992	-0.3057308673595609	[109]	[56]	-2	hSpCas9	negative selection	11733471
2586763	2586786	16	-	28162770	HEL	viability	ATGTTGCTGCCTGACCTCTGGGG	PDPK1	ENSG00000140992	-0.5457062574127534	[489]	[214]	-4	hSpCas9	negative selection	11733472
2586872	2586895	16	+	28162770	HEL	viability	AGCAGGCTGGCGGAAACCCTTGG	PDPK1	ENSG00000140992	0.04913741300532831	[334]	[221]	0	hSpCas9	negative selection	11733473
2557924	2557947	16	+	28162770	HEL	viability	CAAGTTTGGGAAAATCCTTGGGG	PDPK1	ENSG00000140992	-1.0991930150591986	[484]	[144]	-6	hSpCas9	negative selection	11733474
2586836	2586859	16	+	28162770	HEL	viability	AGTTTTCCGAAGATGAGAAGAGG	PDPK1	ENSG00000140992	-0.06040509506911307	[533]	[327]	0	hSpCas9	negative selection	11733475
2586722	2586745	16	-	28162770	MV411	viability	TGACAGGGAGTGTGAGGAGGAGG	PDPK1	ENSG00000140992	-1.1569527042965597	[44]	[16]	-6	hSpCas9	negative selection	11902832
2538115	2538138	16	+	28162770	MV411	viability	GGCCAGGACCACCAGCCAGCTGG	PDPK1	ENSG00000140992	1.0762509007765517	[142]	[253]	8	hSpCas9	negative selection	11902833
2586807	2586830	16	+	28162770	MV411	viability	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-0.9505018268291336	[38]	[16]	-6	hSpCas9	negative selection	11902834
2586862	2586885	16	+	28162770	MV411	viability	TTGTTGGAGAAGCAGGCTGGCGG	PDPK1	ENSG00000140992	0.6762808495866497	[25]	[34]	6	hSpCas9	negative selection	11902835
2538123	2538146	16	-	28162770	MV411	viability	CGCGCTCACCAGCTGGCTGGTGG	PDPK1	ENSG00000140992	-0.4573647199443841	[206]	[126]	-3	hSpCas9	negative selection	11902836
2586687	2586710	16	-	28162770	MV411	viability	GCATGCAGCCAAACTGGCTCAGG	PDPK1	ENSG00000140992	-0.03267036840996007	[84]	[69]	0	hSpCas9	negative selection	11902837
2586763	2586786	16	-	28162770	MV411	viability	ATGTTGCTGCCTGACCTCTGGGG	PDPK1	ENSG00000140992	-0.7058459503101944	[394]	[203]	-5	hSpCas9	negative selection	11902838
2586872	2586895	16	+	28162770	MV411	viability	AGCAGGCTGGCGGAAACCCTTGG	PDPK1	ENSG00000140992	-1.7995259281878115	[280]	[67]	-8	hSpCas9	negative selection	11902839
2557924	2557947	16	+	28162770	MV411	viability	CAAGTTTGGGAAAATCCTTGGGG	PDPK1	ENSG00000140992	-0.35476540002721246	[462]	[304]	-3	hSpCas9	negative selection	11902840
2586836	2586859	16	+	28162770	MV411	viability	AGTTTTCCGAAGATGAGAAGAGG	PDPK1	ENSG00000140992	-1.0623451142424978	[413]	[166]	-6	hSpCas9	negative selection	11902841
2586722	2586745	16	-	28162770	MONOMAC1	viability	TGACAGGGAGTGTGAGGAGGAGG	PDPK1	ENSG00000140992	-1.7275515637583334	[51]	[17]	-8	hSpCas9	negative selection	12072198
2538115	2538138	16	+	28162770	MONOMAC1	viability	GGCCAGGACCACCAGCCAGCTGG	PDPK1	ENSG00000140992	-0.09634284744008059	[82]	[88]	-1	hSpCas9	negative selection	12072199
2586807	2586830	16	+	28162770	MONOMAC1	viability	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-0.19703684705955338	[8]	[8]	-2	hSpCas9	negative selection	12072200
2586862	2586885	16	+	28162770	MONOMAC1	viability	TTGTTGGAGAAGCAGGCTGGCGG	PDPK1	ENSG00000140992	-0.8491135436392465	[10]	[6]	-6	hSpCas9	negative selection	12072201
2538123	2538146	16	-	28162770	MONOMAC1	viability	CGCGCTCACCAGCTGGCTGGTGG	PDPK1	ENSG00000140992	0.5668957947069219	[105]	[179]	5	hSpCas9	negative selection	12072202
2586687	2586710	16	-	28162770	MONOMAC1	viability	GCATGCAGCCAAACTGGCTCAGG	PDPK1	ENSG00000140992	-0.49471739570023887	[58]	[47]	-4	hSpCas9	negative selection	12072203
2586763	2586786	16	-	28162770	MONOMAC1	viability	ATGTTGCTGCCTGACCTCTGGGG	PDPK1	ENSG00000140992	-1.1193145516350358	[270]	[142]	-7	hSpCas9	negative selection	12072204
2586872	2586895	16	+	28162770	MONOMAC1	viability	AGCAGGCTGGCGGAAACCCTTGG	PDPK1	ENSG00000140992	-1.4056234688709712	[207]	[89]	-8	hSpCas9	negative selection	12072205
2557924	2557947	16	+	28162770	MONOMAC1	viability	CAAGTTTGGGAAAATCCTTGGGG	PDPK1	ENSG00000140992	0.39174736461401083	[376]	[566]	4	hSpCas9	negative selection	12072206
2586836	2586859	16	+	28162770	MONOMAC1	viability	AGTTTTCCGAAGATGAGAAGAGG	PDPK1	ENSG00000140992	-1.4073437942384341	[316]	[136]	-8	hSpCas9	negative selection	12072207
2586722	2586745	16	-	28162770	OCIAML2	viability	TGACAGGGAGTGTGAGGAGGAGG	PDPK1	ENSG00000140992	-1.4706298252421615	[7]	[15]	-7	hSpCas9	negative selection	12241564
2538115	2538138	16	+	28162770	OCIAML2	viability	GGCCAGGACCACCAGCCAGCTGG	PDPK1	ENSG00000140992	-0.08158753449626188	[20]	[109]	0	hSpCas9	negative selection	12241565
2586807	2586830	16	+	28162770	OCIAML2	viability	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-1.470629825242161	[8]	[17]	-7	hSpCas9	negative selection	12241566
2586862	2586885	16	+	28162770	OCIAML2	viability	TTGTTGGAGAAGCAGGCTGGCGG	PDPK1	ENSG00000140992	0.744383065728689	[6]	[64]	7	hSpCas9	negative selection	12241567
2538123	2538146	16	-	28162770	OCIAML2	viability	CGCGCTCACCAGCTGGCTGGTGG	PDPK1	ENSG00000140992	0.14336172409052705	[40]	[250]	1	hSpCas9	negative selection	12241568
2586687	2586710	16	-	28162770	OCIAML2	viability	GCATGCAGCCAAACTGGCTCAGG	PDPK1	ENSG00000140992	0.17322636453256368	[19]	[124]	1	hSpCas9	negative selection	12241569
2586763	2586786	16	-	28162770	OCIAML2	viability	ATGTTGCTGCCTGACCTCTGGGG	PDPK1	ENSG00000140992	-1.6245425086958425	[83]	[150]	-7	hSpCas9	negative selection	12241570
2586872	2586895	16	+	28162770	OCIAML2	viability	AGCAGGCTGGCGGAAACCCTTGG	PDPK1	ENSG00000140992	-2.158685818927421	[57]	[71]	-8	hSpCas9	negative selection	12241571
2557924	2557947	16	+	28162770	OCIAML2	viability	CAAGTTTGGGAAAATCCTTGGGG	PDPK1	ENSG00000140992	-1.3007048237998489	[55]	[125]	-7	hSpCas9	negative selection	12241572
2586836	2586859	16	+	28162770	OCIAML2	viability	AGTTTTCCGAAGATGAGAAGAGG	PDPK1	ENSG00000140992	-1.609149689323589	[70]	[128]	-7	hSpCas9	negative selection	12241573
2586722	2586745	16	-	28162770	OCIAML3	viability	TGACAGGGAGTGTGAGGAGGAGG	PDPK1	ENSG00000140992	-0.18961738524482774	[16]	[44]	-1	hSpCas9	negative selection	12410930
2538115	2538138	16	+	28162770	OCIAML3	viability	GGCCAGGACCACCAGCCAGCTGG	PDPK1	ENSG00000140992	0.5249334323993443	[31]	[138]	5	hSpCas9	negative selection	12410931
2586807	2586830	16	+	28162770	OCIAML3	viability	GGACTCGAACTCCTTTGAACTGG	PDPK1	ENSG00000140992	-1.09150729979498	[11]	[16]	-7	hSpCas9	negative selection	12410932
2586862	2586885	16	+	28162770	OCIAML3	viability	TTGTTGGAGAAGCAGGCTGGCGG	PDPK1	ENSG00000140992	0.1715271060388135	[4]	[16]	1	hSpCas9	negative selection	12410933
2538123	2538146	16	-	28162770	OCIAML3	viability	CGCGCTCACCAGCTGGCTGGTGG	PDPK1	ENSG00000140992	0.289799342171314	[41]	[154]	2	hSpCas9	negative selection	12410934
2586687	2586710	16	-	28162770	OCIAML3	viability	GCATGCAGCCAAACTGGCTCAGG	PDPK1	ENSG00000140992	0.4625758880422043	[24]	[103]	4	hSpCas9	negative selection	12410935
2586763	2586786	16	-	28162770	OCIAML3	viability	ATGTTGCTGCCTGACCTCTGGGG	PDPK1	ENSG00000140992	-1.9321763762187363	[133]	[105]	-8	hSpCas9	negative selection	12410936
2586872	2586895	16	+	28162770	OCIAML3	viability	AGCAGGCTGGCGGAAACCCTTGG	PDPK1	ENSG00000140992	-3.178970141045319	[98]	[32]	-9	hSpCas9	negative selection	12410937
2557924	2557947	16	+	28162770	OCIAML3	viability	CAAGTTTGGGAAAATCCTTGGGG	PDPK1	ENSG00000140992	-1.777607578663552	[158]	[139]	-8	hSpCas9	negative selection	12410938
2586836	2586859	16	+	28162770	OCIAML3	viability	AGTTTTCCGAAGATGAGAAGAGG	PDPK1	ENSG00000140992	-2.2106790007726578	[114]	[74]	-8	hSpCas9	negative selection	12410939