Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:5290
• Symbol:PIK3CA
• Description:phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

DataSource: http://genomecrispr.dkfz.de/#!/results/PIK3CA

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
179199769	179199792	3	+	26472758	Jiyoye	viability	GAACGTTTGTAAAGAAGCTGTGG	PIK3CA	ENSG00000121879	0.43474364151467815	[310]	[316]	3	hSpCas9	negative selection	120708
179199727	179199750	3	+	26472758	Jiyoye	viability	GGTTAAAGATCCAGAAGTACAGG	PIK3CA	ENSG00000121879	-2.5257104226355898	[83]	[10]	-9	hSpCas9	negative selection	120709
179210539	179210562	3	+	26472758	Jiyoye	viability	GGATTTAGCTATTCCCACGCAGG	PIK3CA	ENSG00000121879	0.1243324945918991	[263]	[216]	1	hSpCas9	negative selection	120710
179229394	179229417	3	+	26472758	Jiyoye	viability	ACAGCCACACACTACATCAGTGG	PIK3CA	ENSG00000121879	0.9775895736578744	[298]	[443]	6	hSpCas9	negative selection	120711
179198829	179198852	3	-	26472758	Jiyoye	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	1.018819924879535	[124]	[190]	6	hSpCas9	negative selection	120712
179198933	179198956	3	-	26472758	Jiyoye	viability	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-0.21575496941430328	[384]	[249]	-1	hSpCas9	negative selection	120713
179209638	179209661	3	-	26472758	Jiyoye	viability	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	0.08052487637610783	[152]	[121]	0	hSpCas9	negative selection	120714
179210185	179210208	3	+	26472758	Jiyoye	viability	GGAACACTGTCCATTGGCATGGG	PIK3CA	ENSG00000121879	-0.7581092330445297	[387]	[172]	-5	hSpCas9	negative selection	120715
179210430	179210453	3	+	26472758	Jiyoye	viability	GGAAACTCCATGCTTAGAGTTGG	PIK3CA	ENSG00000121879	0.30156519354527467	[169]	[157]	2	hSpCas9	negative selection	120716
179230095	179230118	3	+	26472758	Jiyoye	viability	AACATCATGGTGAAAGACGATGG	PIK3CA	ENSG00000121879	0.38925347350861106	[80]	[79]	3	hSpCas9	negative selection	120717
179199769	179199792	3	+	26472758	KBM7	viability	GAACGTTTGTAAAGAAGCTGTGG	PIK3CA	ENSG00000121879	0.3105183030856895	[1190,945]	[877,386]	3	hSpCas9	negative selection	311826
179199727	179199750	3	+	26472758	KBM7	viability	GGTTAAAGATCCAGAAGTACAGG	PIK3CA	ENSG00000121879	0.2348214469260691	[358,234]	[215,112]	2	hSpCas9	negative selection	311827
179210539	179210562	3	+	26472758	KBM7	viability	GGATTTAGCTATTCCCACGCAGG	PIK3CA	ENSG00000121879	0.41348458996916737	[968,682]	[611,419]	4	hSpCas9	negative selection	311828
179229394	179229417	3	+	26472758	KBM7	viability	ACAGCCACACACTACATCAGTGG	PIK3CA	ENSG00000121879	0.1442416880812929	[2230,1918]	[1203,959]	1	hSpCas9	negative selection	311829
179198829	179198852	3	-	26472758	KBM7	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	0.17972644119183345	[855,766]	[528,344]	1	hSpCas9	negative selection	311830
179198933	179198956	3	-	26472758	KBM7	viability	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	0.10489451623656976	[1142,648]	[555,340]	1	hSpCas9	negative selection	311831
179209638	179209661	3	-	26472758	KBM7	viability	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	0.3237724665230046	[758,852]	[451,503]	3	hSpCas9	negative selection	311832
179210185	179210208	3	+	26472758	KBM7	viability	GGAACACTGTCCATTGGCATGGG	PIK3CA	ENSG00000121879	0.5573702708469004	[1218,1161]	[915,744]	6	hSpCas9	negative selection	311833
179210430	179210453	3	+	26472758	KBM7	viability	GGAAACTCCATGCTTAGAGTTGG	PIK3CA	ENSG00000121879	0.08268386039979747	[701,589]	[218,410]	0	hSpCas9	negative selection	311834
179230095	179230118	3	+	26472758	KBM7	viability	AACATCATGGTGAAAGACGATGG	PIK3CA	ENSG00000121879	-0.2732246633010445	[561,555]	[115,309]	-3	hSpCas9	negative selection	311835
179199769	179199792	3	+	26472758	Raji	viability	GAACGTTTGTAAAGAAGCTGTGG	PIK3CA	ENSG00000121879	-0.07535515179647634	[621]	[136]	0	hSpCas9	negative selection	502944
179199727	179199750	3	+	26472758	Raji	viability	GGTTAAAGATCCAGAAGTACAGG	PIK3CA	ENSG00000121879	0.026463539990031926	[109]	[25]	0	hSpCas9	negative selection	502945
179210539	179210562	3	+	26472758	Raji	viability	GGATTTAGCTATTCCCACGCAGG	PIK3CA	ENSG00000121879	-0.035304881794910536	[445]	[100]	0	hSpCas9	negative selection	502946
179229394	179229417	3	+	26472758	Raji	viability	ACAGCCACACACTACATCAGTGG	PIK3CA	ENSG00000121879	0.8636546523365967	[771]	[325]	7	hSpCas9	negative selection	502947
179198829	179198852	3	-	26472758	Raji	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	1.4184233141182254	[265]	[164]	9	hSpCas9	negative selection	502948
179198933	179198956	3	-	26472758	Raji	viability	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	0.5043192282771325	[400]	[131]	5	hSpCas9	negative selection	502949
179209638	179209661	3	-	26472758	Raji	viability	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	1.1214130952776578	[306]	[154]	8	hSpCas9	negative selection	502950
179210185	179210208	3	+	26472758	Raji	viability	GGAACACTGTCCATTGGCATGGG	PIK3CA	ENSG00000121879	-0.008093682046336426	[493]	[113]	0	hSpCas9	negative selection	502951
179210430	179210453	3	+	26472758	Raji	viability	GGAAACTCCATGCTTAGAGTTGG	PIK3CA	ENSG00000121879	0.8134698166558338	[254]	[103]	7	hSpCas9	negative selection	502952
179230095	179230118	3	+	26472758	Raji	viability	AACATCATGGTGAAAGACGATGG	PIK3CA	ENSG00000121879	0.5291156872264515	[214]	[71]	5	hSpCas9	negative selection	502953
179199769	179199792	3	+	26472758	K562	viability	GAACGTTTGTAAAGAAGCTGTGG	PIK3CA	ENSG00000121879	0.975256592775866	[754]	[1252]	7	hSpCas9	negative selection	694062
179199727	179199750	3	+	26472758	K562	viability	GGTTAAAGATCCAGAAGTACAGG	PIK3CA	ENSG00000121879	-0.13815437636588535	[248]	[190]	-1	hSpCas9	negative selection	694063
179210539	179210562	3	+	26472758	K562	viability	GGATTTAGCTATTCCCACGCAGG	PIK3CA	ENSG00000121879	0.4147952062023791	[709]	[798]	3	hSpCas9	negative selection	694064
179229394	179229417	3	+	26472758	K562	viability	ACAGCCACACACTACATCAGTGG	PIK3CA	ENSG00000121879	0.5664947078536042	[1950]	[2438]	4	hSpCas9	negative selection	694065
179198829	179198852	3	-	26472758	K562	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	0.255838536957551	[754]	[760]	2	hSpCas9	negative selection	694066
179198933	179198956	3	-	26472758	K562	viability	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	0.030389779264625494	[601]	[518]	0	hSpCas9	negative selection	694067
179209638	179209661	3	-	26472758	K562	viability	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	1.1443517725625245	[484]	[904]	8	hSpCas9	negative selection	694068
179210185	179210208	3	+	26472758	K562	viability	GGAACACTGTCCATTGGCATGGG	PIK3CA	ENSG00000121879	0.7101264806041823	[1125]	[1554]	6	hSpCas9	negative selection	694069
179210430	179210453	3	+	26472758	K562	viability	GGAAACTCCATGCTTAGAGTTGG	PIK3CA	ENSG00000121879	1.712425082041754	[487]	[1349]	9	hSpCas9	negative selection	694070
179230095	179230118	3	+	26472758	K562	viability	AACATCATGGTGAAAGACGATGG	PIK3CA	ENSG00000121879	0.11411070532071604	[439]	[401]	0	hSpCas9	negative selection	694071
179204572	179204595	3	-	26627737	DLD1	viability	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-2.6404159754682173	[1055]	[24,63,67]	-9	hSpCas9	negative selection	820521
179209638	179209661	3	-	26627737	DLD1	viability	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	-2.625827315278195	[839]	[35,43,46]	-9	hSpCas9	negative selection	820522
179209679	179209702	3	+	26627737	DLD1	viability	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-0.7924814381508292	[699]	[144,76,150]	-6	hSpCas9	negative selection	820523
179210518	179210541	3	+	26627737	DLD1	viability	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	-0.6939909055216382	[373]	[124,49,44]	-6	hSpCas9	negative selection	820524
179229305	179229328	3	+	26627737	DLD1	viability	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-3.1776165398856775	[1228]	[13,9,93]	-9	hSpCas9	negative selection	820525
179230022	179230045	3	-	26627737	DLD1	viability	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	0.12096723317717403	[503]	[175,225,121]	1	hSpCas9	negative selection	820526
179204572	179204595	3	-	26627737	GBM cells	viability after 5 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-0.20690296960138355	[706]	[388,267]	-3	hSpCas9	negative selection	902836
179209638	179209661	3	-	26627737	GBM cells	viability after 5 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	-0.13864212973791767	[466]	[265,188]	-2	hSpCas9	negative selection	902837
179209679	179209702	3	+	26627737	GBM cells	viability after 5 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-0.152784312763679	[624]	[285,316]	-2	hSpCas9	negative selection	902838
179210518	179210541	3	+	26627737	GBM cells	viability after 5 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	-0.4659042689054231	[366]	[139,144]	-6	hSpCas9	negative selection	902839
179229305	179229328	3	+	26627737	GBM cells	viability after 5 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-0.6677060457136679	[507]	[200,141]	-8	hSpCas9	negative selection	902840
179230022	179230045	3	-	26627737	GBM cells	viability after 5 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	0.20115960391134824	[368]	[199,254]	3	hSpCas9	negative selection	902841
179204572	179204595	3	-	26627737	GBM cells	viability after 13 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-0.22239033986482482	[706]	[421,252]	-3	hSpCas9	negative selection	985151
179209638	179209661	3	-	26627737	GBM cells	viability after 13 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	0.03101817477285085	[466]	[318,209]	0	hSpCas9	negative selection	985152
179209679	179209702	3	+	26627737	GBM cells	viability after 13 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-0.3562011079572027	[624]	[313,224]	-4	hSpCas9	negative selection	985153
179210518	179210541	3	+	26627737	GBM cells	viability after 13 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	-0.7137687150918506	[366]	[116,124]	-7	hSpCas9	negative selection	985154
179229305	179229328	3	+	26627737	GBM cells	viability after 13 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-0.9454496802094121	[507]	[114,165]	-8	hSpCas9	negative selection	985155
179230022	179230045	3	-	26627737	GBM cells	viability after 13 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	0.03787878156408131	[368]	[247,170]	0	hSpCas9	negative selection	985156
179204572	179204595	3	-	26627737	GBM cells	viability after 21 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-0.18312635524939314	[706]	[330,344]	-2	hSpCas9	negative selection	1067466
179209638	179209661	3	-	26627737	GBM cells	viability after 21 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	-0.23766015730026924	[466]	[210,218]	-2	hSpCas9	negative selection	1067467
179209679	179209702	3	+	26627737	GBM cells	viability after 21 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-0.6778205749317209	[624]	[217,206]	-5	hSpCas9	negative selection	1067468
179210518	179210541	3	+	26627737	GBM cells	viability after 21 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	-0.30381409894045847	[366]	[160,161]	-3	hSpCas9	negative selection	1067469
179229305	179229328	3	+	26627737	GBM cells	viability after 21 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-1.1844307030222438	[507]	[122,119]	-7	hSpCas9	negative selection	1067470
179230022	179230045	3	-	26627737	GBM cells	viability after 21 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	0.4844989541290654	[368]	[280,279]	5	hSpCas9	negative selection	1067471
179204572	179204595	3	-	26627737	RPE1	viability after 9 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	0.07813719172028755	[1984]	[607,717]	0	hSpCas9	negative selection	1149781
179209638	179209661	3	-	26627737	RPE1	viability after 9 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	-0.0075717376273347625	[1487]	[479,441]	0	hSpCas9	negative selection	1149782
179209679	179209702	3	+	26627737	RPE1	viability after 9 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	0.8601893070900761	[1820]	[1009,1066]	5	hSpCas9	negative selection	1149783
179210518	179210541	3	+	26627737	RPE1	viability after 9 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	0.43259000641865614	[984]	[358,489]	3	hSpCas9	negative selection	1149784
179229305	179229328	3	+	26627737	RPE1	viability after 9 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-0.6085107775867347	[1886]	[307,489]	-4	hSpCas9	negative selection	1149785
179230022	179230045	3	-	26627737	RPE1	viability after 9 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	1.3079084554600056	[740]	[407,788]	7	hSpCas9	negative selection	1149786
179204572	179204595	3	-	26627737	RPE1	viability after 12 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	0.12216284681630141	[1984]	[662,492]	0	hSpCas9	negative selection	1232096
179209638	179209661	3	-	26627737	RPE1	viability after 12 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	0.18095665149825968	[1487]	[408,499]	1	hSpCas9	negative selection	1232097
179209679	179209702	3	+	26627737	RPE1	viability after 12 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	0.831793801997144	[1820]	[846,895]	5	hSpCas9	negative selection	1232098
179210518	179210541	3	+	26627737	RPE1	viability after 12 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	0.8006650209784618	[984]	[476,443]	5	hSpCas9	negative selection	1232099
179229305	179229328	3	+	26627737	RPE1	viability after 12 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-0.40187862855746925	[1886]	[339,429]	-3	hSpCas9	negative selection	1232100
179230022	179230045	3	-	26627737	RPE1	viability after 12 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	1.4951528780998409	[740]	[533,589]	8	hSpCas9	negative selection	1232101
179204572	179204595	3	-	26627737	RPE1	viability after 15 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	0.24647837460078947	[1984]	[883,455]	1	hSpCas9	negative selection	1314411
179209638	179209661	3	-	26627737	RPE1	viability after 15 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	0.3014762457362896	[1487]	[532,504]	2	hSpCas9	negative selection	1314412
179209679	179209702	3	+	26627737	RPE1	viability after 15 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	0.6336897306531628	[1820]	[870,729]	4	hSpCas9	negative selection	1314413
179210518	179210541	3	+	26627737	RPE1	viability after 15 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	1.2949771168689637	[984]	[728,639]	7	hSpCas9	negative selection	1314414
179229305	179229328	3	+	26627737	RPE1	viability after 15 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-0.8251119707432213	[1886]	[312,289]	-5	hSpCas9	negative selection	1314415
179230022	179230045	3	-	26627737	RPE1	viability after 15 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	1.8290293584638564	[740]	[786,703]	8	hSpCas9	negative selection	1314416
179204572	179204595	3	-	26627737	RPE1	viability after 18 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-0.15634311705121107	[1984]	[441,521]	-1	hSpCas9	negative selection	1396726
179209638	179209661	3	-	26627737	RPE1	viability after 18 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	0.40770560558921276	[1487]	[596,463]	2	hSpCas9	negative selection	1396727
179209679	179209702	3	+	26627737	RPE1	viability after 18 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	0.8957494005415869	[1820]	[836,996]	5	hSpCas9	negative selection	1396728
179210518	179210541	3	+	26627737	RPE1	viability after 18 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	1.2301150263173173	[984]	[756,480]	7	hSpCas9	negative selection	1396729
179229305	179229328	3	+	26627737	RPE1	viability after 18 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-0.6809625180853623	[1886]	[277,359]	-4	hSpCas9	negative selection	1396730
179230022	179230045	3	-	26627737	RPE1	viability after 18 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	1.4649001439709057	[740]	[464,644]	7	hSpCas9	negative selection	1396731
179204572	179204595	3	-	26627737	HeLa	viability after 8 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-0.634149503838858	[1533]	[683,407,265]	-6	hSpCas9	negative selection	1479041
179209638	179209661	3	-	26627737	HeLa	viability after 8 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	0.3976684397862915	[816]	[432,625,346]	3	hSpCas9	negative selection	1479042
179209679	179209702	3	+	26627737	HeLa	viability after 8 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-0.16467005420456404	[1011]	[531,325,353]	-1	hSpCas9	negative selection	1479043
179210518	179210541	3	+	26627737	HeLa	viability after 8 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	0.10801762845187363	[478]	[431,128,162]	1	hSpCas9	negative selection	1479044
179229305	179229328	3	+	26627737	HeLa	viability after 8 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-0.39417510168478864	[599]	[195,179,217]	-4	hSpCas9	negative selection	1479045
179230022	179230045	3	-	26627737	HeLa	viability after 8 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	0.08631084279376944	[475]	[438,168,107]	0	hSpCas9	negative selection	1479046
179204572	179204595	3	-	26627737	HeLa	viability after 12 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-1.3404166263524917	[1533]	[177,230,341]	-8	hSpCas9	negative selection	1561356
179209638	179209661	3	-	26627737	HeLa	viability after 12 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	-0.5984838682712137	[816]	[149,164,357]	-5	hSpCas9	negative selection	1561357
179209679	179209702	3	+	26627737	HeLa	viability after 12 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-0.22210791838364896	[1011]	[146,249,683]	-2	hSpCas9	negative selection	1561358
179210518	179210541	3	+	26627737	HeLa	viability after 12 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	0.3118813091116237	[478]	[146,191,400]	2	hSpCas9	negative selection	1561359
179229305	179229328	3	+	26627737	HeLa	viability after 12 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-0.6004920712079813	[599]	[128,206,148]	-5	hSpCas9	negative selection	1561360
179230022	179230045	3	-	26627737	HeLa	viability after 12 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	-0.2032948005689648	[475]	[153,199,154]	-2	hSpCas9	negative selection	1561361
179204572	179204595	3	-	26627737	HeLa	viability after 15 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-2.010991341909716	[1533]	[147,184,129]	-9	hSpCas9	negative selection	1643671
179209638	179209661	3	-	26627737	HeLa	viability after 15 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	-0.33814724828244613	[816]	[174,369,243]	-3	hSpCas9	negative selection	1643672
179209679	179209702	3	+	26627737	HeLa	viability after 15 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-0.06379924385419988	[1011]	[378,272,541]	0	hSpCas9	negative selection	1643673
179210518	179210541	3	+	26627737	HeLa	viability after 15 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	0.7408783076454896	[478]	[436,203,335]	6	hSpCas9	negative selection	1643674
179229305	179229328	3	+	26627737	HeLa	viability after 15 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-0.43239385070311265	[599]	[107,181,259]	-4	hSpCas9	negative selection	1643675
179230022	179230045	3	-	26627737	HeLa	viability after 15 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	0.6646055970898348	[475]	[350,406,150]	5	hSpCas9	negative selection	1643676
179204572	179204595	3	-	26627737	HeLa	viability after 18 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-2.019879304257787	[1533]	[99,149,129]	-9	hSpCas9	negative selection	1725986
179209638	179209661	3	-	26627737	HeLa	viability after 18 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	-0.36235219038699207	[816]	[113,299,243]	-3	hSpCas9	negative selection	1725987
179209679	179209702	3	+	26627737	HeLa	viability after 18 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-0.09372007804723226	[1011]	[236,227,541]	-1	hSpCas9	negative selection	1725988
179210518	179210541	3	+	26627737	HeLa	viability after 18 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	0.7518819736746171	[478]	[293,173,335]	6	hSpCas9	negative selection	1725989
179229305	179229328	3	+	26627737	HeLa	viability after 18 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-0.42595464418700857	[599]	[72,151,259]	-4	hSpCas9	negative selection	1725990
179230022	179230045	3	-	26627737	HeLa	viability after 18 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	0.6901780288582382	[475]	[242,340,150]	5	hSpCas9	negative selection	1725991
179204572	179204595	3	-	26627737	HCT116	viability after 6 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	0.244048975332672	[1282]	[69,331]	1	hSpCas9	negative selection	1808301
179209638	179209661	3	-	26627737	HCT116	viability after 6 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	0.25711851178303224	[904]	[267,115]	1	hSpCas9	negative selection	1808302
179209679	179209702	3	+	26627737	HCT116	viability after 6 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-0.8504675455696289	[1194]	[167,68]	-5	hSpCas9	negative selection	1808303
179210518	179210541	3	+	26627737	HCT116	viability after 6 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	1.2440514883759186	[802]	[104,405]	6	hSpCas9	negative selection	1808304
179229305	179229328	3	+	26627737	HCT116	viability after 6 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-0.3700685782159278	[1046]	[127,126]	-2	hSpCas9	negative selection	1808305
179230022	179230045	3	-	26627737	HCT116	viability after 6 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	-0.7268125488066384	[813]	[144,39]	-4	hSpCas9	negative selection	1808306
179204572	179204595	3	-	26627737	HCT116	viability after 8 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-0.6949449498711777	[426]	[217,128,90]	-7	hSpCas9	negative selection	1890616
179209638	179209661	3	-	26627737	HCT116	viability after 8 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	-0.5615815469790107	[571]	[226,124,287]	-6	hSpCas9	negative selection	1890617
179209679	179209702	3	+	26627737	HCT116	viability after 8 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-0.5708714947563228	[741]	[261,245,316]	-6	hSpCas9	negative selection	1890618
179210518	179210541	3	+	26627737	HCT116	viability after 8 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	0.553290853939922	[290]	[285,283,137]	5	hSpCas9	negative selection	1890619
179229305	179229328	3	+	26627737	HCT116	viability after 8 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-3.0035677531059983	[505]	[67,10,25]	-9	hSpCas9	negative selection	1890620
179230022	179230045	3	-	26627737	HCT116	viability after 8 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	0.8343458879298858	[297]	[348,289,240]	7	hSpCas9	negative selection	1890621
179204572	179204595	3	-	26627737	HCT116	viability after 9 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-0.3034799783633908	[1282]	[352,217]	-2	hSpCas9	negative selection	1972931
179209638	179209661	3	-	26627737	HCT116	viability after 9 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	-0.7494790488005305	[904]	[212,88]	-5	hSpCas9	negative selection	1972932
179209679	179209702	3	+	26627737	HCT116	viability after 9 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-0.7925488369177539	[1194]	[329,68]	-5	hSpCas9	negative selection	1972933
179210518	179210541	3	+	26627737	HCT116	viability after 9 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	-2.273653290055792	[802]	[83,12]	-9	hSpCas9	negative selection	1972934
179229305	179229328	3	+	26627737	HCT116	viability after 9 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-2.5195256579509087	[1046]	[93,12]	-9	hSpCas9	negative selection	1972935
179230022	179230045	3	-	26627737	HCT116	viability after 9 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	-0.6024795350270029	[813]	[217,83]	-4	hSpCas9	negative selection	1972936
179204572	179204595	3	-	26627737	HCT116	viability after 12 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-0.8768458787170702	[426]	[154,133,74]	-7	hSpCas9	negative selection	2055246
179209638	179209661	3	-	26627737	HCT116	viability after 12 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	-0.9646602663194341	[571]	[153,67,237]	-8	hSpCas9	negative selection	2055247
179209679	179209702	3	+	26627737	HCT116	viability after 12 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-0.8002885229201478	[741]	[199,229,243]	-7	hSpCas9	negative selection	2055248
179210518	179210541	3	+	26627737	HCT116	viability after 12 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	0.20998550754779158	[290]	[236,160,126]	2	hSpCas9	negative selection	2055249
179229305	179229328	3	+	26627737	HCT116	viability after 12 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-3.084654894309226	[505]	[29,24,38]	-9	hSpCas9	negative selection	2055250
179230022	179230045	3	-	26627737	HCT116	viability after 12 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	0.3073632832729119	[297]	[199,241,139]	3	hSpCas9	negative selection	2055251
179204572	179204595	3	-	26627737	HCT116	viability after 15 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-1.8163243758180794	[426]	[80,36,91]	-9	hSpCas9	negative selection	2137561
179209638	179209661	3	-	26627737	HCT116	viability after 15 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	-2.0526644314845433	[571]	[113,66,60]	-9	hSpCas9	negative selection	2137562
179209679	179209702	3	+	26627737	HCT116	viability after 15 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-0.7170352979940914	[741]	[264,137,373]	-6	hSpCas9	negative selection	2137563
179210518	179210541	3	+	26627737	HCT116	viability after 15 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	0.2786123267522447	[290]	[289,143,184]	2	hSpCas9	negative selection	2137564
179229305	179229328	3	+	26627737	HCT116	viability after 15 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-2.6637670310930015	[505]	[57,30,49]	-9	hSpCas9	negative selection	2137565
179230022	179230045	3	-	26627737	HCT116	viability after 15 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	0.3246016476382467	[297]	[129,229,271]	3	hSpCas9	negative selection	2137566
179204572	179204595	3	-	26627737	HCT116	viability after 18 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-1.306077032851657	[426]	[78,54,119]	-8	hSpCas9	negative selection	2219876
179209638	179209661	3	-	26627737	HCT116	viability after 18 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	-1.2729877660525095	[571]	[95,192,45]	-8	hSpCas9	negative selection	2219877
179209679	179209702	3	+	26627737	HCT116	viability after 18 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-1.2480401171314877	[741]	[181,61,217]	-8	hSpCas9	negative selection	2219878
179210518	179210541	3	+	26627737	HCT116	viability after 18 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	0.09737340950849369	[290]	[160,124,167]	0	hSpCas9	negative selection	2219879
179229305	179229328	3	+	26627737	HCT116	viability after 18 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-2.6126732200277316	[505]	[62,38,16]	-9	hSpCas9	negative selection	2219880
179230022	179230045	3	-	26627737	HCT116	viability after 18 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	0.6415869429893729	[297]	[251,172,253]	5	hSpCas9	negative selection	2219881
179162425	179162448	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGTCTTGAACTCCTGGGCTCGAG	PIK3CA	ENSG00000121879	4.2770735618878515	[141,50]	[775,15]	9	dCas9-VP64	positive selection	2397408
179148370	179148393	3	-	25494202	A375	resistance to PLX-4720 (puromycin)	CGACACCTCAGCGGCCGCAGCGG	PIK3CA	ENSG00000121879	0.9598806068682335	[5,8]	[1,3]	4	dCas9-VP64	positive selection	2439671
179148425	179148448	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	CTGGGGCCGCCGGCGAGGCAGGG	PIK3CA	ENSG00000121879	1.2061181782178432	[3,4]	[0,2]	5	dCas9-VP64	positive selection	2439672
179148342	179148365	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	GAAGTAGAAAGCGGCAGTTCCGG	PIK3CA	ENSG00000121879	-1.0702541422121659	[113,276]	[29,9]	-6	dCas9-VP64	positive selection	2439673
179187869	179187892	3	-	25494202	A375	resistance to PLX-4720 (puromycin)	GCCGAGGCGGGCGGATCACAAGG	PIK3CA	ENSG00000121879	0.6864243628519979	[21,12]	[10,0]	3	dCas9-VP64	positive selection	2442717
179202102	179202125	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	TCTCTCAGGCTGGAATGCAGTGG	PIK3CA	ENSG00000121879	-1.4800011787378378	[226,367]	[18,27]	-8	dCas9-VP64	positive selection	2462931
179162425	179162448	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGTCTTGAACTCCTGGGCTCGAG	PIK3CA	ENSG00000121879	0.8672449668792414	[148,204]	[104,104]	6	dCas9-VP64	positive selection	2492663
179148370	179148393	3	-	25494202	A375	resistance to PLX-4720 (zeocin)	CGACACCTCAGCGGCCGCAGCGG	PIK3CA	ENSG00000121879	0.33323377160924716	[57,44]	[20,19]	2	dCas9-VP64	positive selection	2534926
179148425	179148448	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	CTGGGGCCGCCGGCGAGGCAGGG	PIK3CA	ENSG00000121879	-1.6151736996784125	[47,119]	[4,10]	-9	dCas9-VP64	positive selection	2534927
179148342	179148365	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	GAAGTAGAAAGCGGCAGTTCCGG	PIK3CA	ENSG00000121879	0.43805969954994683	[178,176]	[94,62]	3	dCas9-VP64	positive selection	2534928
179187869	179187892	3	-	25494202	A375	resistance to PLX-4720 (zeocin)	GCCGAGGCGGGCGGATCACAAGG	PIK3CA	ENSG00000121879	1.29845831928492	[54,84]	[92,21]	7	dCas9-VP64	positive selection	2537972
179202102	179202125	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	TCTCTCAGGCTGGAATGCAGTGG	PIK3CA	ENSG00000121879	1.4364133282095315	[225,225]	[178,218]	7	dCas9-VP64	positive selection	2558186
179209663	179209686	3	-	27260157	DLD1	viability	TCGGCCTTTAACAGAGCAAATGG	PIK3CA	ENSG00000121879	-0.930967275986683	[]	[]	-6	hSpCas9	negative selection	2573722
179210300	179210323	3	+	27260157	DLD1	viability	CTGAACCCTATTGGTGTTACTGG	PIK3CA	ENSG00000121879	-0.540621414677988	[]	[]	-4	hSpCas9	negative selection	2574353
179199737	179199760	3	-	27260157	DLD1	viability	CTTCGGAAGTCCTGTACTTCTGG	PIK3CA	ENSG00000121879	0.636616860548659	[]	[]	8	hSpCas9	negative selection	2575491
179204526	179204549	3	-	27260157	DLD1	viability	CACATAAGGGTTCTCCTCCATGG	PIK3CA	ENSG00000121879	-2.74069480284875	[]	[]	-9	hSpCas9	negative selection	2577145
179199082	179199105	3	+	27260157	DLD1	viability	CAAGACGACTTTGTGACCTTCGG	PIK3CA	ENSG00000121879	-1.12737695553165	[]	[]	-7	hSpCas9	negative selection	2579493
179198921	179198944	3	+	27260157	DLD1	viability	GACTTTAGAATGCCTCCGTGAGG	PIK3CA	ENSG00000121879	-0.780501358158242	[]	[]	-6	hSpCas9	negative selection	2582536
179210184	179210207	3	+	27260157	DLD1	viability	AGGAACACTGTCCATTGGCATGG	PIK3CA	ENSG00000121879	-1.1601919882672	[]	[]	-7	hSpCas9	negative selection	2586441
179209629	179209652	3	-	27260157	DLD1	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-1.07236290018156	[]	[]	-7	hSpCas9	negative selection	2586534
179210264	179210287	3	+	27260157	DLD1	viability	AATCTTTGGCCAGTACCTCATGG	PIK3CA	ENSG00000121879	-3.35651511562352	[]	[]	-9	hSpCas9	negative selection	2605836
179198826	179198849	3	+	27260157	DLD1	viability	ATGCCTCCACGACCATCATCAGG	PIK3CA	ENSG00000121879	-0.176446266136883	[]	[]	-1	hSpCas9	negative selection	2610399
179203551	179203574	3	+	27260157	DLD1	viability	GAAGCTGTATAATGCTTGGGAGG	PIK3CA	ENSG00000121879	-1.98264780722574	[]	[]	-8	hSpCas9	negative selection	2610568
179198836	179198859	3	+	27260157	DLD1	viability	GACCATCATCAGGTGAACTGTGG	PIK3CA	ENSG00000121879	-1.24930689819433	[]	[]	-7	hSpCas9	negative selection	2614432
179203653	179203676	3	-	27260157	DLD1	viability	TGTAGCTGTGGAAATGCGTCTGG	PIK3CA	ENSG00000121879	-3.29474311210293	[]	[]	-9	hSpCas9	negative selection	2617468
179201363	179201386	3	-	27260157	DLD1	viability	CTTGTTCTGGTACACAGTCATGG	PIK3CA	ENSG00000121879	-2.00096832076724	[]	[]	-8	hSpCas9	negative selection	2618923
179204572	179204595	3	-	27260157	DLD1	viability	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-1.19171779595328	[]	[]	-7	hSpCas9	negative selection	2619705
179201523	179201546	3	-	27260157	DLD1	viability	CTCACCTTATACTGACTCAGAGG	PIK3CA	ENSG00000121879	-0.843974144723449	[]	[]	-6	hSpCas9	negative selection	2620896
179198829	179198852	3	-	27260157	DLD1	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	-1.65013973679307	[]	[]	-8	hSpCas9	negative selection	2623674
179209667	179209690	3	+	27260157	DLD1	viability	TTGCTCTGTTAAAGGCCGAAAGG	PIK3CA	ENSG00000121879	-0.234009712981979	[]	[]	-2	hSpCas9	negative selection	2645663
179204509	179204532	3	+	27260157	DLD1	viability	GTTCGAACAGGTATCTACCATGG	PIK3CA	ENSG00000121879	-2.27955451688591	[]	[]	-9	hSpCas9	negative selection	2648557
179198993	179199016	3	-	27260157	DLD1	viability	CTTGAAGAAGTTGATGGAGGGGG	PIK3CA	ENSG00000121879	-1.40804359352432	[]	[]	-8	hSpCas9	negative selection	2649341
179209663	179209686	3	-	27260157	HT1080	viability	TCGGCCTTTAACAGAGCAAATGG	PIK3CA	ENSG00000121879	-0.265796350613117	[]	[]	0	hSpCas9	negative selection	2649852
179210300	179210323	3	+	27260157	HT1080	viability	CTGAACCCTATTGGTGTTACTGG	PIK3CA	ENSG00000121879	-0.00809698501455561	[]	[]	0	hSpCas9	negative selection	2650483
179199737	179199760	3	-	27260157	HT1080	viability	CTTCGGAAGTCCTGTACTTCTGG	PIK3CA	ENSG00000121879	1.48749030988902	[]	[]	9	hSpCas9	negative selection	2651621
179204526	179204549	3	-	27260157	HT1080	viability	CACATAAGGGTTCTCCTCCATGG	PIK3CA	ENSG00000121879	-1.00252676529754	[]	[]	-8	hSpCas9	negative selection	2653275
179199082	179199105	3	+	27260157	HT1080	viability	CAAGACGACTTTGTGACCTTCGG	PIK3CA	ENSG00000121879	0.481671062408334	[]	[]	4	hSpCas9	negative selection	2655623
179198921	179198944	3	+	27260157	HT1080	viability	GACTTTAGAATGCCTCCGTGAGG	PIK3CA	ENSG00000121879	0.337256783561677	[]	[]	3	hSpCas9	negative selection	2658666
179210184	179210207	3	+	27260157	HT1080	viability	AGGAACACTGTCCATTGGCATGG	PIK3CA	ENSG00000121879	-0.402541345211271	[]	[]	-7	hSpCas9	negative selection	2662571
179209629	179209652	3	-	27260157	HT1080	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	0.578992250924847	[]	[]	5	hSpCas9	negative selection	2662664
179210264	179210287	3	+	27260157	HT1080	viability	AATCTTTGGCCAGTACCTCATGG	PIK3CA	ENSG00000121879	0.180316352710483	[]	[]	1	hSpCas9	negative selection	2681966
179198826	179198849	3	+	27260157	HT1080	viability	ATGCCTCCACGACCATCATCAGG	PIK3CA	ENSG00000121879	1.07099699299721	[]	[]	8	hSpCas9	negative selection	2686529
179203551	179203574	3	+	27260157	HT1080	viability	GAAGCTGTATAATGCTTGGGAGG	PIK3CA	ENSG00000121879	-0.69928623449296	[]	[]	-8	hSpCas9	negative selection	2686698
179198836	179198859	3	+	27260157	HT1080	viability	GACCATCATCAGGTGAACTGTGG	PIK3CA	ENSG00000121879	0.0718629570699454	[]	[]	0	hSpCas9	negative selection	2690562
179203653	179203676	3	-	27260157	HT1080	viability	TGTAGCTGTGGAAATGCGTCTGG	PIK3CA	ENSG00000121879	-2.82351455932577	[]	[]	-9	hSpCas9	negative selection	2693598
179201363	179201386	3	-	27260157	HT1080	viability	CTTGTTCTGGTACACAGTCATGG	PIK3CA	ENSG00000121879	0.438771622965205	[]	[]	4	hSpCas9	negative selection	2695053
179204572	179204595	3	-	27260157	HT1080	viability	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	0.0759666098501237	[]	[]	0	hSpCas9	negative selection	2695835
179201523	179201546	3	-	27260157	HT1080	viability	CTCACCTTATACTGACTCAGAGG	PIK3CA	ENSG00000121879	-0.984876092560249	[]	[]	-8	hSpCas9	negative selection	2697026
179198829	179198852	3	-	27260157	HT1080	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	-0.387109799269898	[]	[]	-7	hSpCas9	negative selection	2699804
179209667	179209690	3	+	27260157	HT1080	viability	TTGCTCTGTTAAAGGCCGAAAGG	PIK3CA	ENSG00000121879	0.667717593045796	[]	[]	6	hSpCas9	negative selection	2721793
179204509	179204532	3	+	27260157	HT1080	viability	GTTCGAACAGGTATCTACCATGG	PIK3CA	ENSG00000121879	-0.579045117416211	[]	[]	-7	hSpCas9	negative selection	2724687
179198993	179199016	3	-	27260157	HT1080	viability	CTTGAAGAAGTTGATGGAGGGGG	PIK3CA	ENSG00000121879	0.426400230368102	[]	[]	4	hSpCas9	negative selection	2725471
179209663	179209686	3	-	27260157	MKN45	viability	TCGGCCTTTAACAGAGCAAATGG	PIK3CA	ENSG00000121879	0.196243857995425	[]	[]	5	hSpCas9	negative selection	2725982
179210300	179210323	3	+	27260157	MKN45	viability	CTGAACCCTATTGGTGTTACTGG	PIK3CA	ENSG00000121879	-0.439878636306688	[]	[]	-6	hSpCas9	negative selection	2726613
179199737	179199760	3	-	27260157	MKN45	viability	CTTCGGAAGTCCTGTACTTCTGG	PIK3CA	ENSG00000121879	0.17287446070869	[]	[]	5	hSpCas9	negative selection	2727751
179204526	179204549	3	-	27260157	MKN45	viability	CACATAAGGGTTCTCCTCCATGG	PIK3CA	ENSG00000121879	-1.06164265404789	[]	[]	-8	hSpCas9	negative selection	2729405
179199082	179199105	3	+	27260157	MKN45	viability	CAAGACGACTTTGTGACCTTCGG	PIK3CA	ENSG00000121879	-0.319831436917613	[]	[]	-1	hSpCas9	negative selection	2731753
179198921	179198944	3	+	27260157	MKN45	viability	GACTTTAGAATGCCTCCGTGAGG	PIK3CA	ENSG00000121879	0.802918693553222	[]	[]	7	hSpCas9	negative selection	2734796
179210184	179210207	3	+	27260157	MKN45	viability	AGGAACACTGTCCATTGGCATGG	PIK3CA	ENSG00000121879	-0.309608453436466	[]	[]	-1	hSpCas9	negative selection	2738701
179209629	179209652	3	-	27260157	MKN45	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	0.0691225078869501	[]	[]	0	hSpCas9	negative selection	2738794
179210264	179210287	3	+	27260157	MKN45	viability	AATCTTTGGCCAGTACCTCATGG	PIK3CA	ENSG00000121879	-1.18184780080276	[]	[]	-8	hSpCas9	negative selection	2758096
179198826	179198849	3	+	27260157	MKN45	viability	ATGCCTCCACGACCATCATCAGG	PIK3CA	ENSG00000121879	1.03167350810589	[]	[]	8	hSpCas9	negative selection	2762659
179203551	179203574	3	+	27260157	MKN45	viability	GAAGCTGTATAATGCTTGGGAGG	PIK3CA	ENSG00000121879	-0.14952514061143	[]	[]	0	hSpCas9	negative selection	2762828
179198836	179198859	3	+	27260157	MKN45	viability	GACCATCATCAGGTGAACTGTGG	PIK3CA	ENSG00000121879	-0.505328131598803	[]	[]	-6	hSpCas9	negative selection	2766692
179203653	179203676	3	-	27260157	MKN45	viability	TGTAGCTGTGGAAATGCGTCTGG	PIK3CA	ENSG00000121879	-3.40922202175618	[]	[]	-9	hSpCas9	negative selection	2769728
179201363	179201386	3	-	27260157	MKN45	viability	CTTGTTCTGGTACACAGTCATGG	PIK3CA	ENSG00000121879	-1.45276541455019	[]	[]	-8	hSpCas9	negative selection	2771183
179204572	179204595	3	-	27260157	MKN45	viability	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-0.89583437601711	[]	[]	-7	hSpCas9	negative selection	2771965
179201523	179201546	3	-	27260157	MKN45	viability	CTCACCTTATACTGACTCAGAGG	PIK3CA	ENSG00000121879	0.529922787961884	[]	[]	6	hSpCas9	negative selection	2773156
179198829	179198852	3	-	27260157	MKN45	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	-1.57386156201609	[]	[]	-9	hSpCas9	negative selection	2775934
179209667	179209690	3	+	27260157	MKN45	viability	TTGCTCTGTTAAAGGCCGAAAGG	PIK3CA	ENSG00000121879	1.03989353714835	[]	[]	8	hSpCas9	negative selection	2797923
179204509	179204532	3	+	27260157	MKN45	viability	GTTCGAACAGGTATCTACCATGG	PIK3CA	ENSG00000121879	-0.703122740283253	[]	[]	-7	hSpCas9	negative selection	2800817
179198993	179199016	3	-	27260157	MKN45	viability	CTTGAAGAAGTTGATGGAGGGGG	PIK3CA	ENSG00000121879	-0.646445011918583	[]	[]	-7	hSpCas9	negative selection	2801601
179209663	179209686	3	-	27260157	RKO	viability	TCGGCCTTTAACAGAGCAAATGG	PIK3CA	ENSG00000121879	-1.3608037061111	[]	[]	-8	hSpCas9	negative selection	2802112
179210300	179210323	3	+	27260157	RKO	viability	CTGAACCCTATTGGTGTTACTGG	PIK3CA	ENSG00000121879	-0.435278204855356	[]	[]	-6	hSpCas9	negative selection	2802743
179199737	179199760	3	-	27260157	RKO	viability	CTTCGGAAGTCCTGTACTTCTGG	PIK3CA	ENSG00000121879	1.14630417105524	[]	[]	9	hSpCas9	negative selection	2803881
179204526	179204549	3	-	27260157	RKO	viability	CACATAAGGGTTCTCCTCCATGG	PIK3CA	ENSG00000121879	-2.78260739274705	[]	[]	-9	hSpCas9	negative selection	2805535
179199082	179199105	3	+	27260157	RKO	viability	CAAGACGACTTTGTGACCTTCGG	PIK3CA	ENSG00000121879	-1.26948069726953	[]	[]	-8	hSpCas9	negative selection	2807883
179198921	179198944	3	+	27260157	RKO	viability	GACTTTAGAATGCCTCCGTGAGG	PIK3CA	ENSG00000121879	-0.759265554070924	[]	[]	-7	hSpCas9	negative selection	2810926
179210184	179210207	3	+	27260157	RKO	viability	AGGAACACTGTCCATTGGCATGG	PIK3CA	ENSG00000121879	-1.47748238233407	[]	[]	-8	hSpCas9	negative selection	2814831
179209629	179209652	3	-	27260157	RKO	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-1.69042805699231	[]	[]	-9	hSpCas9	negative selection	2814924
179210264	179210287	3	+	27260157	RKO	viability	AATCTTTGGCCAGTACCTCATGG	PIK3CA	ENSG00000121879	-1.43098778264718	[]	[]	-8	hSpCas9	negative selection	2834226
179198826	179198849	3	+	27260157	RKO	viability	ATGCCTCCACGACCATCATCAGG	PIK3CA	ENSG00000121879	0.478982782084335	[]	[]	2	hSpCas9	negative selection	2838789
179203551	179203574	3	+	27260157	RKO	viability	GAAGCTGTATAATGCTTGGGAGG	PIK3CA	ENSG00000121879	-0.931498484993574	[]	[]	-8	hSpCas9	negative selection	2838958
179198836	179198859	3	+	27260157	RKO	viability	GACCATCATCAGGTGAACTGTGG	PIK3CA	ENSG00000121879	-1.39521326494734	[]	[]	-8	hSpCas9	negative selection	2842822
179203653	179203676	3	-	27260157	RKO	viability	TGTAGCTGTGGAAATGCGTCTGG	PIK3CA	ENSG00000121879	-2.20923591015338	[]	[]	-9	hSpCas9	negative selection	2845858
179201363	179201386	3	-	27260157	RKO	viability	CTTGTTCTGGTACACAGTCATGG	PIK3CA	ENSG00000121879	-1.8773313205423	[]	[]	-9	hSpCas9	negative selection	2847313
179204572	179204595	3	-	27260157	RKO	viability	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-1.52832088342852	[]	[]	-9	hSpCas9	negative selection	2848095
179201523	179201546	3	-	27260157	RKO	viability	CTCACCTTATACTGACTCAGAGG	PIK3CA	ENSG00000121879	-1.26849321280783	[]	[]	-8	hSpCas9	negative selection	2849286
179198829	179198852	3	-	27260157	RKO	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	-0.573085084884121	[]	[]	-7	hSpCas9	negative selection	2852064
179209667	179209690	3	+	27260157	RKO	viability	TTGCTCTGTTAAAGGCCGAAAGG	PIK3CA	ENSG00000121879	0.51374793328073	[]	[]	2	hSpCas9	negative selection	2874053
179204509	179204532	3	+	27260157	RKO	viability	GTTCGAACAGGTATCTACCATGG	PIK3CA	ENSG00000121879	-2.58643726118936	[]	[]	-9	hSpCas9	negative selection	2876947
179198993	179199016	3	-	27260157	RKO	viability	CTTGAAGAAGTTGATGGAGGGGG	PIK3CA	ENSG00000121879	-1.16919632052907	[]	[]	-8	hSpCas9	negative selection	2877731
179209663	179209686	3	-	27260157	SF268	viability	TCGGCCTTTAACAGAGCAAATGG	PIK3CA	ENSG00000121879	0.264432440061882	[]	[]	4	hSpCas9	negative selection	2878242
179210300	179210323	3	+	27260157	SF268	viability	CTGAACCCTATTGGTGTTACTGG	PIK3CA	ENSG00000121879	0.434291601949642	[]	[]	7	hSpCas9	negative selection	2878873
179199737	179199760	3	-	27260157	SF268	viability	CTTCGGAAGTCCTGTACTTCTGG	PIK3CA	ENSG00000121879	0.531585839108571	[]	[]	8	hSpCas9	negative selection	2880011
179204526	179204549	3	-	27260157	SF268	viability	CACATAAGGGTTCTCCTCCATGG	PIK3CA	ENSG00000121879	-0.236843202280604	[]	[]	-2	hSpCas9	negative selection	2881665
179199082	179199105	3	+	27260157	SF268	viability	CAAGACGACTTTGTGACCTTCGG	PIK3CA	ENSG00000121879	0.0158306760131855	[]	[]	0	hSpCas9	negative selection	2884013
179198921	179198944	3	+	27260157	SF268	viability	GACTTTAGAATGCCTCCGTGAGG	PIK3CA	ENSG00000121879	0.968643735730345	[]	[]	9	hSpCas9	negative selection	2887056
179210184	179210207	3	+	27260157	SF268	viability	AGGAACACTGTCCATTGGCATGG	PIK3CA	ENSG00000121879	0.7443413231937	[]	[]	8	hSpCas9	negative selection	2890961
179209629	179209652	3	-	27260157	SF268	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	0.635051569670573	[]	[]	8	hSpCas9	negative selection	2891054
179210264	179210287	3	+	27260157	SF268	viability	AATCTTTGGCCAGTACCTCATGG	PIK3CA	ENSG00000121879	0.0399873122228413	[]	[]	0	hSpCas9	negative selection	2910356
179198826	179198849	3	+	27260157	SF268	viability	ATGCCTCCACGACCATCATCAGG	PIK3CA	ENSG00000121879	1.01678940486154	[]	[]	9	hSpCas9	negative selection	2914919
179203551	179203574	3	+	27260157	SF268	viability	GAAGCTGTATAATGCTTGGGAGG	PIK3CA	ENSG00000121879	0.238243138721331	[]	[]	3	hSpCas9	negative selection	2915088
179198836	179198859	3	+	27260157	SF268	viability	GACCATCATCAGGTGAACTGTGG	PIK3CA	ENSG00000121879	0.237849916541019	[]	[]	3	hSpCas9	negative selection	2918952
179203653	179203676	3	-	27260157	SF268	viability	TGTAGCTGTGGAAATGCGTCTGG	PIK3CA	ENSG00000121879	-2.26302087069985	[]	[]	-9	hSpCas9	negative selection	2921988
179201363	179201386	3	-	27260157	SF268	viability	CTTGTTCTGGTACACAGTCATGG	PIK3CA	ENSG00000121879	-0.838290677366551	[]	[]	-6	hSpCas9	negative selection	2923443
179204572	179204595	3	-	27260157	SF268	viability	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	0.353808411052238	[]	[]	4	hSpCas9	negative selection	2924225
179201523	179201546	3	-	27260157	SF268	viability	CTCACCTTATACTGACTCAGAGG	PIK3CA	ENSG00000121879	-0.385894802970689	[]	[]	-3	hSpCas9	negative selection	2925416
179198829	179198852	3	-	27260157	SF268	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	-0.593961880804616	[]	[]	-4	hSpCas9	negative selection	2928194
179209667	179209690	3	+	27260157	SF268	viability	TTGCTCTGTTAAAGGCCGAAAGG	PIK3CA	ENSG00000121879	1.15547686351591	[]	[]	9	hSpCas9	negative selection	2950183
179204509	179204532	3	+	27260157	SF268	viability	GTTCGAACAGGTATCTACCATGG	PIK3CA	ENSG00000121879	0.670349657050479	[]	[]	8	hSpCas9	negative selection	2953077
179198993	179199016	3	-	27260157	SF268	viability	CTTGAAGAAGTTGATGGAGGGGG	PIK3CA	ENSG00000121879	0.212983593443701	[]	[]	3	hSpCas9	negative selection	2953861
179198922	179198945	3	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GACTTTAGAATGCCTCCGTGAGG	PIK3CA	ENSG00000121879	-0.4424484824039795	[3,2]	[1,1]	-6	hSpCas9	positive selection	3011367
179198890	179198913	3	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTAGAATGTTTACTACCAAATGG	PIK3CA	ENSG00000121879	-0.34030307776203456	[3,3]	[2,1]	-5	hSpCas9	positive selection	3011368
179199121	179199144	3	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TTAAAAGTAATTGAACCAGTAGG	PIK3CA	ENSG00000121879	-0.20378017251499886	[4,4]	[4,1]	-3	hSpCas9	positive selection	3011369
179198933	179198956	3	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-0.15441210760414625	[2,3]	[2,1]	-2	hSpCas9	positive selection	3011370
179198922	179198945	3	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GACTTTAGAATGCCTCCGTGAGG	PIK3CA	ENSG00000121879	-0.05914293308281085	[3,3]	[0,2]	-1	hSpCas9	positive selection	3079225
179198890	179198913	3	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTAGAATGTTTACTACCAAATGG	PIK3CA	ENSG00000121879	-0.15182521973175342	[3,3]	[3,1]	-2	hSpCas9	positive selection	3079226
179199121	179199144	3	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TTAAAAGTAATTGAACCAGTAGG	PIK3CA	ENSG00000121879	0.23464412725127948	[4,4]	[4,3]	4	hSpCas9	positive selection	3079227
179198933	179198956	3	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-0.05331764213913362	[2,2]	[4,0]	0	hSpCas9	positive selection	3079228
179209629	179209652		-	24336571	A375	resistance to PLX after 7 days	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	0.014225499826477805	[8,8]	[8,7]	0	hSpCas9	positive selection	3135623
179201523	179201546		-	24336571	A375	resistance to PLX after 7 days	CTCACCTTATACTGACTCAGAGG	PIK3CA	ENSG00000121879	0.35113446416760624	[8,8]	[11,10]	8	hSpCas9	positive selection	3135624
179201376	179201399		-	24336571	A375	resistance to PLX after 7 days	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.1626928377418948	[7,6]	[6,5]	-5	hSpCas9	positive selection	3135625
179209629	179209652		-	24336571	A375	resistance to PLX after 14 days	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	0.8750042357354735	[5,4]	[4,3]	7	hSpCas9	positive selection	3193416
179201523	179201546		-	24336571	A375	resistance to PLX after 14 days	CTCACCTTATACTGACTCAGAGG	PIK3CA	ENSG00000121879	0.609215970990045	[10,6]	[6,4]	5	hSpCas9	positive selection	3193417
179201376	179201399		-	24336571	A375	resistance to PLX after 14 days	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.691292221928711	[13,4]	[1,2]	-7	hSpCas9	positive selection	3193418
179209629	179209652		-	24336571	A375	viability after 7 days	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	0.23370520195432876	[7]	[8,8]	3	hSpCas9	negative selection	3251209
179201523	179201546		-	24336571	A375	viability after 7 days	CTCACCTTATACTGACTCAGAGG	PIK3CA	ENSG00000121879	-0.7735248938016333	[16]	[8,8]	-8	hSpCas9	negative selection	3251210
179201376	179201399		-	24336571	A375	viability after 7 days	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.19218059422117761	[8]	[7,6]	-3	hSpCas9	negative selection	3251211
179209629	179209652		-	24336571	A375	viability after 14 days	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.43339179628122726	[7]	[5,4]	-5	hSpCas9	negative selection	3309002
179201523	179201546		-	24336571	A375	viability after 14 days	CTCACCTTATACTGACTCAGAGG	PIK3CA	ENSG00000121879	-0.8144144556501883	[16]	[10,6]	-7	hSpCas9	negative selection	3309003
179201376	179201399		-	24336571	A375	viability after 14 days	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	0.1588741226160345	[8]	[13,4]	2	hSpCas9	negative selection	3309004
179209629	179209652	3	-	27383988	293T	resistance to West Nile virus (flavivirus)	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.09140194278524241	[162,162]	[0,0]	0	hSpCas9	positive selection	3385879
179201282	179201305	3	+	27383988	293T	resistance to West Nile virus (flavivirus)	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	0.8997742068277513	[81,81]	[0,0]	4	hSpCas9	positive selection	3385880
179209682	179209705	3	-	27383988	293T	resistance to West Nile virus (flavivirus)	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	4.485742420410053	[477,477]	[69,69]	9	hSpCas9	positive selection	3385881
179198921	179198944	3	+	26780180	HT29	viability (Avana library 4 designs)	GACTTTAGAATGCCTCCGTGAGG	PIK3CA	ENSG00000121879	5.10638772936353	[]	[]	9	hSpCas9	negative selection	3449450
179198889	179198912	3	+	26780180	HT29	viability (Avana library 4 designs)	GTAGAATGTTTACTACCAAATGG	PIK3CA	ENSG00000121879	2.7621262775277	[]	[]	8	hSpCas9	negative selection	3449451
179199120	179199143	3	+	26780180	HT29	viability (Avana library 4 designs)	TTAAAAGTAATTGAACCAGTAGG	PIK3CA	ENSG00000121879	0.910619367078193	[]	[]	3	hSpCas9	negative selection	3449452
179198933	179198956	3	-	26780180	HT29	viability (Avana library 4 designs)	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	4.4508472826727	[]	[]	9	hSpCas9	negative selection	3449453
179198933	179198956	3	-	26780180	A375	viability (Avana lentiCRISPRv2)	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-7.89488731741687	[]	[]	-7	hSpCas9	negative selection	3544219
179198889	179198912	3	+	26780180	A375	viability (Avana lentiCRISPRv2)	GTAGAATGTTTACTACCAAATGG	PIK3CA	ENSG00000121879	-15.8702354281491	[]	[]	-9	hSpCas9	negative selection	3544220
179199120	179199143	3	+	26780180	A375	viability (Avana lentiCRISPRv2)	TTAAAAGTAATTGAACCAGTAGG	PIK3CA	ENSG00000121879	-13.1292268204672	[]	[]	-8	hSpCas9	negative selection	3544221
179198921	179198944	3	+	26780180	A375	viability (Avana lentiCRISPRv2)	GACTTTAGAATGCCTCCGTGAGG	PIK3CA	ENSG00000121879	3.76671493542187	[]	[]	6	hSpCas9	negative selection	3544222
179210553	179210576	3	-	26780180	A375	viability (Avana lentiCRISPRv2)	TTTGCCTTACCAGTCCTGCGTGG	PIK3CA	ENSG00000121879	-0.597695045485475	[]	[]	0	hSpCas9	negative selection	3544223
179198864	179198887	3	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGATTCTTGGGGGCATCAAGTGG	PIK3CA	ENSG00000121879	-2.34834329437335	[]	[]	-3	hSpCas9	negative selection	3544224
179198933	179198956	3	-	26780180	A375	viability (Avana lentiGuide)	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	5.32180897772591	[]	[]	5	hSpCas9	negative selection	3652878
179198889	179198912	3	+	26780180	A375	viability (Avana lentiGuide)	GTAGAATGTTTACTACCAAATGG	PIK3CA	ENSG00000121879	-4.07832986408211	[]	[]	-7	hSpCas9	negative selection	3652879
179199120	179199143	3	+	26780180	A375	viability (Avana lentiGuide)	TTAAAAGTAATTGAACCAGTAGG	PIK3CA	ENSG00000121879	-2.51905645275845	[]	[]	-4	hSpCas9	negative selection	3652880
179198921	179198944	3	+	26780180	A375	viability (Avana lentiGuide)	GACTTTAGAATGCCTCCGTGAGG	PIK3CA	ENSG00000121879	13.1298063762547	[]	[]	7	hSpCas9	negative selection	3652881
179210553	179210576	3	-	26780180	A375	viability (Avana lentiGuide)	TTTGCCTTACCAGTCCTGCGTGG	PIK3CA	ENSG00000121879	2.20163138156683	[]	[]	2	hSpCas9	negative selection	3652882
179198864	179198887	3	-	26780180	A375	viability (Avana lentiGuide)	GGATTCTTGGGGGCATCAAGTGG	PIK3CA	ENSG00000121879	6.69706080439478	[]	[]	5	hSpCas9	negative selection	3652883
179198933	179198956	3	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-0.6509381736973487	[6]	[3,3]	-7	hSpCas9	positive selection	3761537
179198889	179198912	3	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTAGAATGTTTACTACCAAATGG	PIK3CA	ENSG00000121879	-0.5943897399884414	[8]	[5,4]	-7	hSpCas9	positive selection	3761538
179199120	179199143	3	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTAAAAGTAATTGAACCAGTAGG	PIK3CA	ENSG00000121879	-0.688836678192629	[9]	[5,4]	-7	hSpCas9	positive selection	3761539
179198921	179198944	3	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GACTTTAGAATGCCTCCGTGAGG	PIK3CA	ENSG00000121879	0.20161115658693204	[5]	[5,5]	5	hSpCas9	positive selection	3761540
179210553	179210576	3	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTTGCCTTACCAGTCCTGCGTGG	PIK3CA	ENSG00000121879	0.029409822926505264	[4]	[4,3]	0	hSpCas9	positive selection	3761541
179198864	179198887	3	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGATTCTTGGGGGCATCAAGTGG	PIK3CA	ENSG00000121879	-0.1756516881978829	[3]	[3,2]	-3	hSpCas9	positive selection	3761542
179198933	179198956	3	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-0.10382139041992752	[5]	[5,3]	-1	hSpCas9	positive selection	3870144
179198889	179198912	3	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTAGAATGTTTACTACCAAATGG	PIK3CA	ENSG00000121879	0.24565821435216567	[4]	[4,5]	6	hSpCas9	positive selection	3870145
179199120	179199143	3	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTAAAAGTAATTGAACCAGTAGG	PIK3CA	ENSG00000121879	0.23345043686093103	[6]	[7,5]	6	hSpCas9	positive selection	3870146
179198921	179198944	3	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GACTTTAGAATGCCTCCGTGAGG	PIK3CA	ENSG00000121879	-0.11814410251651812	[5]	[5,3]	-2	hSpCas9	positive selection	3870147
179210553	179210576	3	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTTGCCTTACCAGTCCTGCGTGG	PIK3CA	ENSG00000121879	-0.4396063000368942	[5]	[4,1]	-5	hSpCas9	positive selection	3870148
179198864	179198887	3	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGATTCTTGGGGGCATCAAGTGG	PIK3CA	ENSG00000121879	-0.6397577404334356	[4]	[0,3]	-7	hSpCas9	positive selection	3870149
179209629	179209652	3	-	26780180	A375	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	1.51536261354268	[]	[]	8	hSpCas9	negative selection	3980951
179210291	179210314	3	+	26780180	A375	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	1.11590754454346	[]	[]	5	hSpCas9	negative selection	3980952
179201376	179201399	3	-	26780180	A375	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	1.43380191791478	[]	[]	8	hSpCas9	negative selection	3980953
179210228	179210251	3	+	26780180	A375	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	0.967858068501273	[]	[]	4	hSpCas9	negative selection	3980954
179201282	179201305	3	+	26780180	A375	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	0.800865082987044	[]	[]	3	hSpCas9	negative selection	3980955
179209682	179209705	3	-	26780180	A375	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.0170463678824567	[]	[]	0	hSpCas9	negative selection	3980956
179209629	179209652	3	-	26780180	HT29	viability (GeCKOv2 library)	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	2.14731124074087	[]	[]	9	hSpCas9	negative selection	4088917
179210291	179210314	3	+	26780180	HT29	viability (GeCKOv2 library)	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	1.13574886721672	[]	[]	5	hSpCas9	negative selection	4088918
179201376	179201399	3	-	26780180	HT29	viability (GeCKOv2 library)	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	1.75274015513876	[]	[]	8	hSpCas9	negative selection	4088919
179210228	179210251	3	+	26780180	HT29	viability (GeCKOv2 library)	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	1.09546971508213	[]	[]	5	hSpCas9	negative selection	4088920
179201282	179201305	3	+	26780180	HT29	viability (GeCKOv2 library)	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	1.60300742547609	[]	[]	8	hSpCas9	negative selection	4088921
179209682	179209705	3	-	26780180	HT29	viability (GeCKOv2 library)	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.162651992281192	[]	[]	0	hSpCas9	negative selection	4088922
179209629	179209652	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.25164401898182065	[3]	[1,1]	-6	hSpCas9	positive selection	4160576
179201523	179201546	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTCACCTTATACTGACTCAGAGG	PIK3CA	ENSG00000121879	0.054730277481622375	[3]	[2,2]	1	hSpCas9	positive selection	4160577
179201376	179201399	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.5214109955563213	[2]	[0,0]	-8	hSpCas9	positive selection	4160578
179209629	179209652	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.17641861998738417	[2]	[1,1,0,0]	-3	hSpCas9	positive selection	4224598
179201523	179201546	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTCACCTTATACTGACTCAGAGG	PIK3CA	ENSG00000121879	-0.031524824840190924	[4]	[4,3,0,0]	0	hSpCas9	positive selection	4224599
179201376	179201399	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.3792223437397378	[2]	[0,0,0,0]	-5	hSpCas9	positive selection	4224600
179210228	179210251	3	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	0.33214039013311253	[4]	[4,4]	6	hSpCas9	positive selection	4290282
179210291	179210314	3	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.47878376178818316	[2]	[2,2]	8	hSpCas9	positive selection	4290283
179201376	179201399	3	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.38990490433618796	[2]	[1,0]	-7	hSpCas9	positive selection	4290284
179209629	179209652	3	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.11836308624573215	[2]	[2,1]	-2	hSpCas9	positive selection	4354534
179201282	179201305	3	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	0.257732047018095	[2]	[1,2]	5	hSpCas9	positive selection	4354535
179209682	179209705	3	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.15256820554348016	[3]	[4,2]	3	hSpCas9	positive selection	4354536
179198933	179198955	3	-	27760321	OCIAML3	viability	TATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-0.8824823931186851	[200,210]	[76,101]	-7	hSpCas9	negative selection	4427841
179203755	179203777	3	-	27760321	OCIAML3	viability	CGAATATTTACATTCACGTAGG	PIK3CA	ENSG00000121879	0.9643980953829785	[130,116]	[89,317]	9	hSpCas9	negative selection	4427842
179204510	179204532	3	+	27760321	OCIAML3	viability	TTCGAACAGGTATCTACCATGG	PIK3CA	ENSG00000121879	-0.6215467522560001	[149,112]	[31,110]	-6	hSpCas9	negative selection	4427843
179209680	179209702	3	+	27760321	OCIAML3	viability	GGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	0.13917585191368165	[286,207]	[204,218]	1	hSpCas9	negative selection	4427844
179210513	179210535	3	-	27760321	OCIAML3	viability	TCTCGGGATACAGACCAATTGG	PIK3CA	ENSG00000121879	0.24651684330950907	[247,232]	[221,224]	3	hSpCas9	negative selection	4427845
179198933	179198955	3	-	27760321	OCIAML2	viability	TATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-0.26323738693222665	[200,210]	[95,196]	-3	hSpCas9	negative selection	4511304
179203755	179203777	3	-	27760321	OCIAML2	viability	CGAATATTTACATTCACGTAGG	PIK3CA	ENSG00000121879	-0.56563610942504	[130,116]	[71,61]	-6	hSpCas9	negative selection	4511305
179204510	179204532	3	+	27760321	OCIAML2	viability	TTCGAACAGGTATCTACCATGG	PIK3CA	ENSG00000121879	0.08289179362324317	[149,112]	[128,88]	1	hSpCas9	negative selection	4511306
179209680	179209702	3	+	27760321	OCIAML2	viability	GGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	0.23129188670226242	[286,207]	[230,234]	3	hSpCas9	negative selection	4511307
179210513	179210535	3	-	27760321	OCIAML2	viability	TCTCGGGATACAGACCAATTGG	PIK3CA	ENSG00000121879	-0.22986304274113056	[247,232]	[162,169]	-3	hSpCas9	negative selection	4511308
179198933	179198955	3	-	27760321	MV411	viability	TATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	0.07371528611565781	[200,210]	[168,105]	0	hSpCas9	negative selection	4594767
179203755	179203777	3	-	27760321	MV411	viability	CGAATATTTACATTCACGTAGG	PIK3CA	ENSG00000121879	-1.6420422870389249	[130,116]	[4,57]	-8	hSpCas9	negative selection	4594768
179204510	179204532	3	+	27760321	MV411	viability	TTCGAACAGGTATCTACCATGG	PIK3CA	ENSG00000121879	1.0005538677243053	[149,112]	[154,197]	7	hSpCas9	negative selection	4594769
179209680	179209702	3	+	27760321	MV411	viability	GGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	0.39437879572287815	[286,207]	[168,277]	3	hSpCas9	negative selection	4594770
179210513	179210535	3	-	27760321	MV411	viability	TCTCGGGATACAGACCAATTGG	PIK3CA	ENSG00000121879	0.27866708891014014	[247,232]	[25,442]	2	hSpCas9	negative selection	4594771
179198933	179198955	3	-	27760321	HL60	viability	TATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-0.12939596933518938	[200,210]	[109,201]	-1	hSpCas9	negative selection	4678230
179203755	179203777	3	-	27760321	HL60	viability	CGAATATTTACATTCACGTAGG	PIK3CA	ENSG00000121879	0.3656849876960433	[130,116]	[124,135]	4	hSpCas9	negative selection	4678231
179204510	179204532	3	+	27760321	HL60	viability	TTCGAACAGGTATCTACCATGG	PIK3CA	ENSG00000121879	3.4116408809860443	[149,112]	[873,1408]	9	hSpCas9	negative selection	4678232
179209680	179209702	3	+	27760321	HL60	viability	GGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	0.12648047331318302	[286,207]	[169,269]	1	hSpCas9	negative selection	4678233
179210513	179210535	3	-	27760321	HL60	viability	TCTCGGGATACAGACCAATTGG	PIK3CA	ENSG00000121879	-0.38773708344565283	[247,232]	[125,175]	-4	hSpCas9	negative selection	4678234
179198933	179198955	3	-	27760321	HT1080	viability	TATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-1.4334818111427698	[210,164]	[0,56]	-5	hSpCas9	negative selection	4761693
179203755	179203777	3	-	27760321	HT1080	viability	CGAATATTTACATTCACGTAGG	PIK3CA	ENSG00000121879	0.3704820672908229	[116,91]	[39,68]	2	hSpCas9	negative selection	4761694
179204510	179204532	3	+	27760321	HT1080	viability	TTCGAACAGGTATCTACCATGG	PIK3CA	ENSG00000121879	-4.290729883795617	[112,87]	[2,0]	-8	hSpCas9	negative selection	4761695
179209680	179209702	3	+	27760321	HT1080	viability	GGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	0.6327634084042009	[207,162]	[137,88]	3	hSpCas9	negative selection	4761696
179210513	179210535	3	-	27760321	HT1080	viability	TCTCGGGATACAGACCAATTGG	PIK3CA	ENSG00000121879	1.6768246523122783	[232,181]	[217,314]	8	hSpCas9	negative selection	4761697
179198933	179198955	3	-	27760321	HT29	viability after 7 days	TATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-1.488597327761426	[210,164]	[119,115,28]	-9	hSpCas9	negative selection	4845156
179203755	179203777	3	-	27760321	HT29	viability after 7 days	CGAATATTTACATTCACGTAGG	PIK3CA	ENSG00000121879	-0.4295306596101762	[116,91]	[137,43,121]	-6	hSpCas9	negative selection	4845157
179204510	179204532	3	+	27760321	HT29	viability after 7 days	TTCGAACAGGTATCTACCATGG	PIK3CA	ENSG00000121879	-0.13993990381570742	[112,87]	[151,69,133]	-2	hSpCas9	negative selection	4845158
179209680	179209702	3	+	27760321	HT29	viability after 7 days	GGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-0.5382240867885648	[207,162]	[53,230,190]	-7	hSpCas9	negative selection	4845159
179210513	179210535	3	-	27760321	HT29	viability after 7 days	TCTCGGGATACAGACCAATTGG	PIK3CA	ENSG00000121879	0.46569119400743386	[232,181]	[419,318,372]	7	hSpCas9	negative selection	4845160
179198933	179198955	3	-	27760321	HT29	viability after 25 days	TATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-6.105235254220517	[210,164]	[0,0,7]	-9	hSpCas9	negative selection	4928619
179203755	179203777	3	-	27760321	HT29	viability after 25 days	CGAATATTTACATTCACGTAGG	PIK3CA	ENSG00000121879	0.4412393532249561	[116,91]	[175,134,175]	5	hSpCas9	negative selection	4928620
179204510	179204532	3	+	27760321	HT29	viability after 25 days	TTCGAACAGGTATCTACCATGG	PIK3CA	ENSG00000121879	-5.023911202855123	[112,87]	[0,3,5]	-9	hSpCas9	negative selection	4928621
179209680	179209702	3	+	27760321	HT29	viability after 25 days	GGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-1.7644086265170629	[207,162]	[38,83,65]	-8	hSpCas9	negative selection	4928622
179210513	179210535	3	-	27760321	HT29	viability after 25 days	TCTCGGGATACAGACCAATTGG	PIK3CA	ENSG00000121879	-2.32820099159958	[232,181]	[78,52,2]	-8	hSpCas9	negative selection	4928623
179198933	179198955	3	-	27760321	HT29	viability after 22 days	TATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-4.77130714437425	[210,164]	[0,21,0]	-9	hSpCas9	negative selection	5012082
179203755	179203777	3	-	27760321	HT29	viability after 22 days	CGAATATTTACATTCACGTAGG	PIK3CA	ENSG00000121879	-0.1407668834669622	[116,91]	[66,51,211]	-1	hSpCas9	negative selection	5012083
179204510	179204532	3	+	27760321	HT29	viability after 22 days	TTCGAACAGGTATCTACCATGG	PIK3CA	ENSG00000121879	-3.657412541872003	[112,87]	[0,0,25]	-9	hSpCas9	negative selection	5012084
179209680	179209702	3	+	27760321	HT29	viability after 22 days	GGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-1.2230879577993734	[207,162]	[199,56,14]	-7	hSpCas9	negative selection	5012085
179210513	179210535	3	-	27760321	HT29	viability after 22 days	TCTCGGGATACAGACCAATTGG	PIK3CA	ENSG00000121879	-2.3960818984311327	[232,181]	[32,64,38]	-8	hSpCas9	negative selection	5012086
179198933	179198955	3	-	27760321	HT29	viability after 19 days	TATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-7.748107189699505	[210,164]	[0,0,0]	-9	hSpCas9	negative selection	5095545
179203755	179203777	3	-	27760321	HT29	viability after 19 days	CGAATATTTACATTCACGTAGG	PIK3CA	ENSG00000121879	-0.7618507098866767	[116,91]	[16,13,170]	-6	hSpCas9	negative selection	5095546
179204510	179204532	3	+	27760321	HT29	viability after 19 days	TTCGAACAGGTATCTACCATGG	PIK3CA	ENSG00000121879	-2.3010586376398434	[112,87]	[36,0,32]	-8	hSpCas9	negative selection	5095547
179209680	179209702	3	+	27760321	HT29	viability after 19 days	GGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-2.8842143079326448	[207,162]	[46,35,5]	-8	hSpCas9	negative selection	5095548
179210513	179210535	3	-	27760321	HT29	viability after 19 days	TCTCGGGATACAGACCAATTGG	PIK3CA	ENSG00000121879	-0.8039913056409359	[232,181]	[165,246,2]	-6	hSpCas9	negative selection	5095549
179198933	179198955	3	-	27760321	HT29	viability after 16 days	TATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-3.68789689771554	[210,164]	[12,2,32]	-9	hSpCas9	negative selection	5179008
179203755	179203777	3	-	27760321	HT29	viability after 16 days	CGAATATTTACATTCACGTAGG	PIK3CA	ENSG00000121879	-1.3454995145319788	[116,91]	[60,64,12]	-7	hSpCas9	negative selection	5179009
179204510	179204532	3	+	27760321	HT29	viability after 16 days	TTCGAACAGGTATCTACCATGG	PIK3CA	ENSG00000121879	-1.2755968937876412	[112,87]	[21,7,107]	-7	hSpCas9	negative selection	5179010
179209680	179209702	3	+	27760321	HT29	viability after 16 days	GGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-2.2561701221997374	[207,162]	[45,27,56]	-8	hSpCas9	negative selection	5179011
179210513	179210535	3	-	27760321	HT29	viability after 16 days	TCTCGGGATACAGACCAATTGG	PIK3CA	ENSG00000121879	-1.490971234339094	[232,181]	[81,71,93]	-8	hSpCas9	negative selection	5179012
179198933	179198955	3	-	27760321	HT29	viability after 13 days	TATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-2.7175518009270196	[210,164]	[0,89,9]	-9	hSpCas9	negative selection	5262471
179203755	179203777	3	-	27760321	HT29	viability after 13 days	CGAATATTTACATTCACGTAGG	PIK3CA	ENSG00000121879	-0.2102894210948143	[116,91]	[19,126,163]	-2	hSpCas9	negative selection	5262472
179204510	179204532	3	+	27760321	HT29	viability after 13 days	TTCGAACAGGTATCTACCATGG	PIK3CA	ENSG00000121879	-2.853952183385749	[112,87]	[42,0,4]	-9	hSpCas9	negative selection	5262473
179209680	179209702	3	+	27760321	HT29	viability after 13 days	GGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-1.3514034041549567	[207,162]	[41,123,86]	-8	hSpCas9	negative selection	5262474
179210513	179210535	3	-	27760321	HT29	viability after 13 days	TCTCGGGATACAGACCAATTGG	PIK3CA	ENSG00000121879	-1.4401719728681477	[232,181]	[8,94,157]	-8	hSpCas9	negative selection	5262475
179198933	179198955	3	-	27760321	HT29	viability after 10 days	TATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-1.9437767376896282	[210,164]	[100,21,58]	-9	hSpCas9	negative selection	5345934
179203755	179203777	3	-	27760321	HT29	viability after 10 days	CGAATATTTACATTCACGTAGG	PIK3CA	ENSG00000121879	-1.1115075122244422	[116,91]	[68,51,59]	-8	hSpCas9	negative selection	5345935
179204510	179204532	3	+	27760321	HT29	viability after 10 days	TTCGAACAGGTATCTACCATGG	PIK3CA	ENSG00000121879	-1.924498217520518	[112,87]	[21,14,60]	-9	hSpCas9	negative selection	5345936
179209680	179209702	3	+	27760321	HT29	viability after 10 days	GGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-1.4614703591012044	[207,162]	[36,57,154]	-8	hSpCas9	negative selection	5345937
179210513	179210535	3	-	27760321	HT29	viability after 10 days	TCTCGGGATACAGACCAATTGG	PIK3CA	ENSG00000121879	-1.5642803232302134	[232,181]	[112,99,50]	-8	hSpCas9	negative selection	5345938
179198933	179198955	3	-	27760321	MOLM13	viability	TATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-0.16914383615164152	[200,210]	[131,79]	-1	hSpCas9	negative selection	5429397
179203755	179203777	3	-	27760321	MOLM13	viability	CGAATATTTACATTCACGTAGG	PIK3CA	ENSG00000121879	0.07453911283320913	[130,116]	[38,102]	0	hSpCas9	negative selection	5429398
179204510	179204532	3	+	27760321	MOLM13	viability	TTCGAACAGGTATCTACCATGG	PIK3CA	ENSG00000121879	-1.5708599605837508	[149,112]	[0,44]	-7	hSpCas9	negative selection	5429399
179209680	179209702	3	+	27760321	MOLM13	viability	GGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-0.12887298165496885	[286,207]	[153,102]	-1	hSpCas9	negative selection	5429400
179210513	179210535	3	-	27760321	MOLM13	viability	TCTCGGGATACAGACCAATTGG	PIK3CA	ENSG00000121879	0.9264069515651547	[247,232]	[431,109]	6	hSpCas9	negative selection	5429401
179148372	179148395	3	+	27661255	K562	viability	GCTGCGGCCGCTGAGGTGTCGGG	PIK3CA	ENSG00000121879	-0.042078821498452434	[371,600]	[370,376]	-2	dCas9-KRAB	negative selection	5501913
179148379	179148402	3	-	27661255	K562	viability	GCAGCAGCCCGACACCTCAGCGG	PIK3CA	ENSG00000121879	-0.2930758536555286	[466,469]	[272,332]	-7	dCas9-KRAB	negative selection	5501914
179148746	179148769	3	-	27661255	K562	viability	GGAGAGGGTGCGGCGATCGCAGG	PIK3CA	ENSG00000121879	0.4285552640473833	[94,111]	[131,92]	9	dCas9-KRAB	negative selection	5501915
179148767	179148790	3	-	27661255	K562	viability	GAGAGGCCAGAGGCAGGCGAGGG	PIK3CA	ENSG00000121879	-0.2926945385671995	[1326,1324]	[908,826]	-7	dCas9-KRAB	negative selection	5501916
179148840	179148863	3	-	27661255	K562	viability	GAAGCAAAGGAAGAGCGAGGCGG	PIK3CA	ENSG00000121879	-0.11715677821706849	[942,1270]	[777,838]	-4	dCas9-KRAB	negative selection	5501917
179210228	179210251	3	+	27260156	BXPC3	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	-0.13604842227046698	[1385]	[1211,1143,1297,1677]	-3	hSpCas9	negative selection	5562742
179210291	179210314	3	+	27260156	BXPC3	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.007366025989862024	[285]	[302,303,336,249]	0	hSpCas9	negative selection	5562743
179201376	179201399	3	-	27260156	BXPC3	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.2574124121556436	[205]	[169,138,160,262]	-5	hSpCas9	negative selection	5562744
179209629	179209652	3	-	27260156	BXPC3	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.37849212890105666	[425]	[349,303,390,322]	-7	hSpCas9	negative selection	5626994
179201282	179201305	3	+	27260156	BXPC3	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-0.8757700687823495	[231]	[111,146,98,175]	-9	hSpCas9	negative selection	5626995
179209682	179209705	3	-	27260156	BXPC3	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.24249639684805402	[975]	[1137,1198,1152,1355]	5	hSpCas9	negative selection	5626996
179210228	179210251	3	+	27260156	A673	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	-0.15593020513408495	[1385]	[1719,1354,1435,1490]	-4	hSpCas9	negative selection	5683993
179210291	179210314	3	+	27260156	A673	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.15897201193120225	[285]	[362,411,398,353]	4	hSpCas9	negative selection	5683994
179201376	179201399	3	-	27260156	A673	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.03647892610694958	[205]	[281,247,199,238]	-1	hSpCas9	negative selection	5683995
179209629	179209652	3	-	27260156	A673	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.10772375922139454	[425]	[479,466,442,510]	-3	hSpCas9	negative selection	5748245
179201282	179201305	3	+	27260156	A673	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-0.4238058191256422	[231]	[220,215,226,164]	-8	hSpCas9	negative selection	5748246
179209682	179209705	3	-	27260156	A673	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.39231943858760565	[975]	[1754,1623,1239,1556]	8	hSpCas9	negative selection	5748247
179210228	179210251	3	+	27260156	A375	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	0.0658188286388266	[1385]	[1653,2075,1678,1444]	0	hSpCas9	negative selection	5805244
179210291	179210314	3	+	27260156	A375	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.38185273676814424	[285]	[345,613,473,340]	5	hSpCas9	negative selection	5805245
179201376	179201399	3	-	27260156	A375	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.48725037982427577	[205]	[196,157,164,164]	-6	hSpCas9	negative selection	5805246
179209629	179209652	3	-	27260156	A375	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	0.07329904689633598	[425]	[606,516,585,396]	1	hSpCas9	negative selection	5869496
179201282	179201305	3	+	27260156	A375	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-1.2190491389463414	[231]	[88,213,118,62]	-8	hSpCas9	negative selection	5869497
179209682	179209705	3	-	27260156	A375	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.4643314599645607	[975]	[1779,1518,1508,1481]	6	hSpCas9	negative selection	5869498
179210228	179210251	3	+	27260156	COLO741	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	0.20134478030767045	[1385]	[2289,2079,1774]	4	hSpCas9	negative selection	5926495
179210291	179210314	3	+	27260156	COLO741	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.09103830389067424	[285]	[339,478,346]	2	hSpCas9	negative selection	5926496
179201376	179201399	3	-	27260156	COLO741	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.268569611222919	[205]	[220,156,272]	-5	hSpCas9	negative selection	5926497
179209629	179209652	3	-	27260156	COLO741	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.060741630088141235	[425]	[490,536,532]	-1	hSpCas9	negative selection	5990747
179201282	179201305	3	+	27260156	COLO741	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-0.3884622339976085	[231]	[287,225,173]	-7	hSpCas9	negative selection	5990748
179209682	179209705	3	-	27260156	COLO741	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.2685077151360604	[975]	[1468,1524,1505]	5	hSpCas9	negative selection	5990749
179210228	179210251	3	+	27260156	CAL120	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	0.012083972027485457	[1385]	[1886,1713,1639]	0	hSpCas9	negative selection	6047746
179210291	179210314	3	+	27260156	CAL120	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.6233803164640257	[285]	[1059,363,301]	8	hSpCas9	negative selection	6047747
179201376	179201399	3	-	27260156	CAL120	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	0.22752057069967824	[205]	[455,182,284]	3	hSpCas9	negative selection	6047748
179209629	179209652	3	-	27260156	CAL120	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	0.1439937538996114	[425]	[813,539,439]	2	hSpCas9	negative selection	6111998
179201282	179201305	3	+	27260156	CAL120	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-0.8345807002916339	[231]	[178,137,170]	-8	hSpCas9	negative selection	6111999
179209682	179209705	3	-	27260156	CAL120	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.4971832968458385	[975]	[1927,2080,1174]	7	hSpCas9	negative selection	6112000
179210228	179210251	3	+	27260156	CADOES1	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	-0.01630840191040339	[1385]	[1177,1256,1196,1473]	0	hSpCas9	negative selection	6168997
179210291	179210314	3	+	27260156	CADOES1	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.5180159866549732	[285]	[350,371,512,283]	8	hSpCas9	negative selection	6168998
179201376	179201399	3	-	27260156	CADOES1	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	0.01464883875365186	[205]	[150,233,230,156]	0	hSpCas9	negative selection	6168999
179209629	179209652	3	-	27260156	CADOES1	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.03308438687258858	[425]	[342,386,456,360]	0	hSpCas9	negative selection	6233249
179201282	179201305	3	+	27260156	CADOES1	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	0.3638837477144806	[231]	[233,340,256,278]	6	hSpCas9	negative selection	6233250
179209682	179209705	3	-	27260156	CADOES1	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.5824480919675175	[975]	[1265,1252,1377,1546]	8	hSpCas9	negative selection	6233251
179210228	179210251	3	+	27260156	EWS502	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	-0.038613356679299216	[1385]	[1513,1404,1289,1495]	0	hSpCas9	negative selection	6290248
179210291	179210314	3	+	27260156	EWS502	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.23578140572321676	[285]	[348,353,360,362]	4	hSpCas9	negative selection	6290249
179201376	179201399	3	-	27260156	EWS502	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	0.020356754130732124	[205]	[250,324,164,127]	0	hSpCas9	negative selection	6290250
179209629	179209652	3	-	27260156	EWS502	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.3165116074929857	[425]	[305,299,330,531]	-5	hSpCas9	negative selection	6354500
179201282	179201305	3	+	27260156	EWS502	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-0.4349888678665337	[231]	[122,273,90,244]	-6	hSpCas9	negative selection	6354501
179209682	179209705	3	-	27260156	EWS502	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.44372494973577936	[975]	[1306,1613,1190,1514]	7	hSpCas9	negative selection	6354502
179210228	179210251	3	+	27260156	EW8	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	-0.17254959374320555	[1385]	[1365,949,821,915]	-3	hSpCas9	negative selection	6411499
179210291	179210314	3	+	27260156	EW8	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.1755124855893212	[285]	[336,208,203,313]	3	hSpCas9	negative selection	6411500
179201376	179201399	3	-	27260156	EW8	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.13665507431067625	[205]	[227,143,82,171]	-3	hSpCas9	negative selection	6411501
179209629	179209652	3	-	27260156	EW8	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.1416990334476245	[425]	[415,294,230,333]	-3	hSpCas9	negative selection	6475751
179201282	179201305	3	+	27260156	EW8	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-0.5651521934141885	[231]	[142,94,129,140]	-8	hSpCas9	negative selection	6475752
179209682	179209705	3	-	27260156	EW8	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.5231567120758234	[975]	[1195,1102,949,1331]	8	hSpCas9	negative selection	6475753
179210228	179210251	3	+	27260156	CORL105	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	0.04774263839519888	[1385]	[1528,1608,1880,1716]	0	hSpCas9	negative selection	6532750
179210291	179210314	3	+	27260156	CORL105	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.2933387262937276	[285]	[474,236,464,477]	5	hSpCas9	negative selection	6532751
179201376	179201399	3	-	27260156	CORL105	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.06652297474181168	[205]	[306,159,341,133]	-1	hSpCas9	negative selection	6532752
179209629	179209652	3	-	27260156	CORL105	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.14363776241063334	[425]	[437,425,516,434]	-3	hSpCas9	negative selection	6597002
179201282	179201305	3	+	27260156	CORL105	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-0.21410527649620748	[231]	[204,239,319,183]	-4	hSpCas9	negative selection	6597003
179209682	179209705	3	-	27260156	CORL105	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.35506081375235454	[975]	[1610,1386,1504,1355]	6	hSpCas9	negative selection	6597004
179210228	179210251	3	+	27260156	HS294T	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	0.3243210657067266	[1385]	[572,561,778,802]	4	hSpCas9	negative selection	6654001
179210291	179210314	3	+	27260156	HS294T	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.7181264510028024	[285]	[218,121,94,310]	8	hSpCas9	negative selection	6654002
179201376	179201399	3	-	27260156	HS294T	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.47277989256584707	[205]	[51,47,63,67]	-6	hSpCas9	negative selection	6654003
179209629	179209652	3	-	27260156	HS294T	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.1989847665089601	[425]	[120,126,155,177]	-3	hSpCas9	negative selection	6718253
179201282	179201305	3	+	27260156	HS294T	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-0.20937642062115214	[231]	[65,104,67,69]	-3	hSpCas9	negative selection	6718254
179209682	179209705	3	-	27260156	HS294T	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.4144346367395906	[975]	[547,552,399,502]	5	hSpCas9	negative selection	6718255
179210228	179210251	3	+	27260156	HCC44	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	0.24527458242632982	[1385]	[2075,2095,1694,1518]	4	hSpCas9	negative selection	6775252
179210291	179210314	3	+	27260156	HCC44	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.7961112308920404	[285]	[453,460,356,926]	9	hSpCas9	negative selection	6775253
179201376	179201399	3	-	27260156	HCC44	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.32395511652503717	[205]	[148,194,127,253]	-5	hSpCas9	negative selection	6775254
179209629	179209652	3	-	27260156	HCC44	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.16639481876419418	[425]	[456,387,561,340]	-3	hSpCas9	negative selection	6839504
179201282	179201305	3	+	27260156	HCC44	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-1.1646155695147684	[231]	[131,86,160,100]	-9	hSpCas9	negative selection	6839505
179209682	179209705	3	-	27260156	HCC44	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.45507388681022	[975]	[1205,1132,2090,1728]	7	hSpCas9	negative selection	6839506
179210228	179210251	3	+	27260156	G402	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	0.33720337416949797	[1385]	[1776,2078,3285,1377]	4	hSpCas9	negative selection	6896503
179210291	179210314	3	+	27260156	G402	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.10523210317412723	[285]	[311,387,359,428]	1	hSpCas9	negative selection	6896504
179201376	179201399	3	-	27260156	G402	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	0.04264140435817376	[205]	[331,296,193,225]	0	hSpCas9	negative selection	6896505
179209629	179209652	3	-	27260156	G402	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	0.006444827716758195	[425]	[628,459,331,669]	0	hSpCas9	negative selection	6960755
179201282	179201305	3	+	27260156	G402	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-0.3363019246877752	[231]	[184,168,114,408]	-4	hSpCas9	negative selection	6960756
179209682	179209705	3	-	27260156	G402	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.7809410989555579	[975]	[2261,2331,1775,1863]	8	hSpCas9	negative selection	6960757
179210228	179210251	3	+	27260156	L33	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	0.15511677766074072	[1385]	[1355,687,916,1681]	3	hSpCas9	negative selection	7017754
179210291	179210314	3	+	27260156	L33	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.39297447381155687	[285]	[458,187,160,325]	7	hSpCas9	negative selection	7017755
179201376	179201399	3	-	27260156	L33	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.3382482950180947	[205]	[201,62,87,154]	-7	hSpCas9	negative selection	7017756
179209629	179209652	3	-	27260156	L33	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.013660346840418836	[425]	[365,139,325,462]	0	hSpCas9	negative selection	7082006
179201282	179201305	3	+	27260156	L33	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-0.1179890179738401	[231]	[266,100,117,152]	-3	hSpCas9	negative selection	7082007
179209682	179209705	3	-	27260156	L33	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.43037249471062866	[975]	[1359,491,739,1518]	8	hSpCas9	negative selection	7082008
179210228	179210251	3	+	27260156	K562	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	0.16526555635997897	[1385]	[1471,1674,948,1431]	2	hSpCas9	negative selection	7139005
179210291	179210314	3	+	27260156	K562	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.33092476038582835	[285]	[378,196,613,108]	4	hSpCas9	negative selection	7139006
179201376	179201399	3	-	27260156	K562	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	1.0919103184387295	[205]	[574,271,366,355]	9	hSpCas9	negative selection	7139007
179209629	179209652	3	-	27260156	K562	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.002193593786238124	[425]	[289,304,455,438]	0	hSpCas9	negative selection	7203257
179201282	179201305	3	+	27260156	K562	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-0.027831843515028876	[231]	[124,95,295,269]	0	hSpCas9	negative selection	7203258
179209682	179209705	3	-	27260156	K562	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.7657809083733267	[975]	[1978,1286,1685,1017]	8	hSpCas9	negative selection	7203259
179210228	179210251	3	+	27260156	HT29	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	-0.2787392240925972	[1385]	[1293,1523,1436,1304]	-5	hSpCas9	negative selection	7260256
179210291	179210314	3	+	27260156	HT29	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	-0.08769516517590292	[285]	[342,338,285,338]	-2	hSpCas9	negative selection	7260257
179201376	179201399	3	-	27260156	HT29	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.30027242086729444	[205]	[222,218,206,169]	-5	hSpCas9	negative selection	7260258
179209629	179209652	3	-	27260156	HT29	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.7994599639445056	[425]	[288,356,271,276]	-8	hSpCas9	negative selection	7324508
179201282	179201305	3	+	27260156	HT29	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-1.1970434382484376	[231]	[140,171,125,64]	-9	hSpCas9	negative selection	7324509
179209682	179209705	3	-	27260156	HT29	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.44458674820079813	[975]	[1591,1732,1701,1448]	8	hSpCas9	negative selection	7324510
179210228	179210251	3	+	27260156	MHHES1	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	-0.04728751411426413	[1385]	[1488,1431,1736,1372]	-1	hSpCas9	negative selection	7381507
179210291	179210314	3	+	27260156	MHHES1	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.46394165170733614	[285]	[258,508,318,620]	7	hSpCas9	negative selection	7381508
179201376	179201399	3	-	27260156	MHHES1	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	0.10386510246174896	[205]	[212,254,230,280]	2	hSpCas9	negative selection	7381509
179209629	179209652	3	-	27260156	MHHES1	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.4138405717004222	[425]	[577,326,365,217]	-7	hSpCas9	negative selection	7445759
179201282	179201305	3	+	27260156	MHHES1	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-0.2457154648031492	[231]	[67,181,282,301]	-4	hSpCas9	negative selection	7445760
179209682	179209705	3	-	27260156	MHHES1	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.6339687126837017	[975]	[1941,1770,1723,1443]	9	hSpCas9	negative selection	7445761
179210228	179210251	3	+	27260156	MEWO	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	-0.006436846087542136	[1385]	[1409,1399,1084]	0	hSpCas9	negative selection	7502758
179210291	179210314	3	+	27260156	MEWO	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.4206790931884121	[285]	[509,319,273]	8	hSpCas9	negative selection	7502759
179201376	179201399	3	-	27260156	MEWO	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.35488340779096905	[205]	[155,168,127]	-6	hSpCas9	negative selection	7502760
179209629	179209652	3	-	27260156	MEWO	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.10615670351596551	[425]	[465,224,438]	-2	hSpCas9	negative selection	7567010
179201282	179201305	3	+	27260156	MEWO	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	0.08454745453248769	[231]	[279,241,177]	1	hSpCas9	negative selection	7567011
179209682	179209705	3	-	27260156	MEWO	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.3102094907469275	[975]	[1222,1296,892]	6	hSpCas9	negative selection	7567012
179210228	179210251	3	+	27260156	LNCAPCLONEFGC	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	0.2503810822433712	[1385]	[1351,1412,1729,1520]	4	hSpCas9	negative selection	7624009
179210291	179210314	3	+	27260156	LNCAPCLONEFGC	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.19475703286983737	[285]	[275,257,445,230]	3	hSpCas9	negative selection	7624010
179201376	179201399	3	-	27260156	LNCAPCLONEFGC	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	0.5484998857460007	[205]	[231,284,282,292]	8	hSpCas9	negative selection	7624011
179209629	179209652	3	-	27260156	LNCAPCLONEFGC	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	0.15159876263581015	[425]	[526,464,394,317]	2	hSpCas9	negative selection	7688261
179201282	179201305	3	+	27260156	LNCAPCLONEFGC	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-0.03546672644315074	[231]	[119,152,432,152]	0	hSpCas9	negative selection	7688262
179209682	179209705	3	-	27260156	LNCAPCLONEFGC	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.5971713606816882	[975]	[1137,957,1843,1512]	8	hSpCas9	negative selection	7688263
179210228	179210251	3	+	27260156	PANC0327	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	0.004267921616406767	[1385]	[1059,922,1413,1567]	0	hSpCas9	negative selection	7745260
179210291	179210314	3	+	27260156	PANC0327	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	-0.08749528735887202	[285]	[242,314,266,121]	-1	hSpCas9	negative selection	7745261
179201376	179201399	3	-	27260156	PANC0327	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.17828543832388766	[205]	[184,174,141,144]	-3	hSpCas9	negative selection	7745262
179209629	179209652	3	-	27260156	PANC0327	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.006354611181593722	[425]	[461,334,244,476]	0	hSpCas9	negative selection	7809512
179201282	179201305	3	+	27260156	PANC0327	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-1.2574451796774777	[231]	[74,123,81,57]	-9	hSpCas9	negative selection	7809513
179209682	179209705	3	-	27260156	PANC0327	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.5574051024856539	[975]	[1248,1474,1127,1222]	7	hSpCas9	negative selection	7809514
179210228	179210251	3	+	27260156	NCIH2009	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	-0.2694690518178353	[1385]	[1929,1485,1466]	-4	hSpCas9	negative selection	7866511
179210291	179210314	3	+	27260156	NCIH2009	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	-0.39240633573223893	[285]	[449,168,324]	-5	hSpCas9	negative selection	7866512
179201376	179201399	3	-	27260156	NCIH2009	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.35826723982013453	[205]	[264,179,236]	-5	hSpCas9	negative selection	7866513
179209629	179209652	3	-	27260156	NCIH2009	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.46008401882288563	[425]	[628,436,269]	-5	hSpCas9	negative selection	7930763
179201282	179201305	3	+	27260156	NCIH2009	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-1.5105836714147653	[231]	[110,88,140]	-9	hSpCas9	negative selection	7930764
179209682	179209705	3	-	27260156	NCIH2009	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.7738522730632682	[975]	[2720,1819,2535]	9	hSpCas9	negative selection	7930765
179210228	179210251	3	+	27260156	NCIH1373	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	0.5354167512857597	[1385]	[1934,1748,2828,653]	5	hSpCas9	negative selection	7987762
179210291	179210314	3	+	27260156	NCIH1373	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.5344798757210234	[285]	[420,237,382,224]	5	hSpCas9	negative selection	7987763
179201376	179201399	3	-	27260156	NCIH1373	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	0.35533387805264505	[205]	[364,339,392,18]	3	hSpCas9	negative selection	7987764
179209629	179209652	3	-	27260156	NCIH1373	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.06696611287340448	[425]	[754,406,296,108]	0	hSpCas9	negative selection	8052014
179201282	179201305	3	+	27260156	NCIH1373	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-1.346462826725315	[231]	[180,130,32,18]	-8	hSpCas9	negative selection	8052015
179209682	179209705	3	-	27260156	NCIH1373	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	1.1602770302160725	[975]	[2794,2178,2520,616]	9	hSpCas9	negative selection	8052016
179210228	179210251	3	+	27260156	PATU8902	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	-1.2082588421159774	[1385]	[659,1265,592,888]	-8	hSpCas9	negative selection	8109013
179210291	179210314	3	+	27260156	PATU8902	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	-1.9122745038248916	[285]	[40,161,111,106]	-9	hSpCas9	negative selection	8109014
179201376	179201399	3	-	27260156	PATU8902	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.5337201807028995	[205]	[92,65,330,276]	-5	hSpCas9	negative selection	8109015
179209629	179209652	3	-	27260156	PATU8902	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.5107626727502167	[425]	[62,419,570,593]	-5	hSpCas9	negative selection	8173265
179201282	179201305	3	+	27260156	PATU8902	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-2.316886486982881	[231]	[141,12,43,63]	-9	hSpCas9	negative selection	8173266
179209682	179209705	3	-	27260156	PATU8902	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.7143192812852692	[975]	[2100,3054,1405,2603]	7	hSpCas9	negative selection	8173267
179210228	179210251	3	+	27260156	PANC1	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	0.4508328797291783	[1385]	[1406,1937,1739,1488]	7	hSpCas9	negative selection	8230264
179210291	179210314	3	+	27260156	PANC1	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.6017749706758626	[285]	[286,453,451,319]	8	hSpCas9	negative selection	8230265
179201376	179201399	3	-	27260156	PANC1	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	0.2212364647563937	[205]	[163,222,297,150]	3	hSpCas9	negative selection	8230266
179209629	179209652	3	-	27260156	PANC1	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.38228728933224443	[425]	[193,376,268,296]	-5	hSpCas9	negative selection	8294516
179201282	179201305	3	+	27260156	PANC1	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-0.018318699078911926	[231]	[85,224,187,278]	0	hSpCas9	negative selection	8294517
179209682	179209705	3	-	27260156	PANC1	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.6616563686892527	[975]	[1357,1382,1514,1079]	9	hSpCas9	negative selection	8294518
179210228	179210251	3	+	27260156	PANC0813	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	-0.2936163403049097	[1385]	[1448,1293,1359,1224]	-5	hSpCas9	negative selection	8351515
179210291	179210314	3	+	27260156	PANC0813	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	-0.18630238620452666	[285]	[285,293,343,257]	-3	hSpCas9	negative selection	8351516
179201376	179201399	3	-	27260156	PANC0813	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	0.039372280747257626	[205]	[189,162,257,370]	0	hSpCas9	negative selection	8351517
179209629	179209652	3	-	27260156	PANC0813	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.6156831323994245	[425]	[349,323,361,274]	-7	hSpCas9	negative selection	8415767
179201282	179201305	3	+	27260156	PANC0813	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-1.2944238912327883	[231]	[169,86,71,119]	-9	hSpCas9	negative selection	8415768
179209682	179209705	3	-	27260156	PANC0813	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.5752330442678857	[975]	[1813,1736,1840,1461]	8	hSpCas9	negative selection	8415769
179210228	179210251	3	+	27260156	RDES	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	-0.22618872717083227	[1385]	[1079,1264,1425,1774]	-4	hSpCas9	negative selection	8472766
179210291	179210314	3	+	27260156	RDES	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.03946844439608865	[285]	[218,233,387,576]	0	hSpCas9	negative selection	8472767
179201376	179201399	3	-	27260156	RDES	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.1465549737290497	[205]	[198,164,111,406]	-2	hSpCas9	negative selection	8472768
179209629	179209652	3	-	27260156	RDES	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.31883586445696876	[425]	[286,452,337,514]	-5	hSpCas9	negative selection	8537018
179201282	179201305	3	+	27260156	RDES	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-0.9228222074148684	[231]	[160,99,133,165]	-9	hSpCas9	negative selection	8537019
179209682	179209705	3	-	27260156	RDES	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.5208317699854392	[975]	[1148,1596,1857,1954]	8	hSpCas9	negative selection	8537020
179210228	179210251	3	+	27260156	PC3	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	0.21393373344260969	[1385]	[1006,1238,2930,1890]	5	hSpCas9	negative selection	8594017
179210291	179210314	3	+	27260156	PC3	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.020269624495833694	[285]	[207,264,370,351]	0	hSpCas9	negative selection	8594018
179201376	179201399	3	-	27260156	PC3	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.19451256755410462	[205]	[106,202,289,173]	-4	hSpCas9	negative selection	8594019
179209629	179209652	3	-	27260156	PC3	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.1588483654597961	[425]	[285,312,659,372]	-4	hSpCas9	negative selection	8658269
179201282	179201305	3	+	27260156	PC3	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	0.05880848355616475	[231]	[143,232,503,203]	1	hSpCas9	negative selection	8658270
179209682	179209705	3	-	27260156	PC3	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.27301191429765037	[975]	[738,1027,1785,1485]	6	hSpCas9	negative selection	8658271
179210228	179210251	3	+	27260156	PATU8988T	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	0.10743968798740466	[1385]	[1252,1828,1278,1448]	1	hSpCas9	negative selection	8715268
179210291	179210314	3	+	27260156	PATU8988T	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.2080887251708341	[285]	[368,341,327,232]	3	hSpCas9	negative selection	8715269
179201376	179201399	3	-	27260156	PATU8988T	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.5787600076045045	[205]	[101,110,137,183]	-7	hSpCas9	negative selection	8715270
179209629	179209652	3	-	27260156	PATU8988T	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	0.24654008662877236	[425]	[546,710,228,490]	4	hSpCas9	negative selection	8779520
179201282	179201305	3	+	27260156	PATU8988T	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-0.5258292061762213	[231]	[43,104,270,199]	-7	hSpCas9	negative selection	8779521
179209682	179209705	3	-	27260156	PATU8988T	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.591329106165329	[975]	[1285,1657,1377,1380]	8	hSpCas9	negative selection	8779522
179210228	179210251	3	+	27260156	T47D	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	-0.0745126593837746	[1385]	[1579,1399,1575,1589]	-2	hSpCas9	negative selection	8836519
179210291	179210314	3	+	27260156	T47D	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	-0.03465840848835966	[285]	[257,284,342,420]	-1	hSpCas9	negative selection	8836520
179201376	179201399	3	-	27260156	T47D	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.2652887000784425	[205]	[227,143,253,175]	-5	hSpCas9	negative selection	8836521
179209629	179209652	3	-	27260156	T47D	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.6404101706900024	[425]	[267,246,310,457]	-8	hSpCas9	negative selection	8900771
179201282	179201305	3	+	27260156	T47D	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-0.8304609620121348	[231]	[149,152,168,134]	-9	hSpCas9	negative selection	8900772
179209682	179209705	3	-	27260156	T47D	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.5466817826676253	[975]	[1606,1580,1747,1713]	9	hSpCas9	negative selection	8900773
179210228	179210251	3	+	27260156	SU8686	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	0.3111410690353311	[1385]	[1686,1727,1728,1653]	5	hSpCas9	negative selection	8957770
179210291	179210314	3	+	27260156	SU8686	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.246663405809961	[285]	[370,213,398,379]	4	hSpCas9	negative selection	8957771
179201376	179201399	3	-	27260156	SU8686	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	0.16410458469560374	[205]	[192,251,253,213]	2	hSpCas9	negative selection	8957772
179209629	179209652	3	-	27260156	SU8686	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	0.14151353150573773	[425]	[488,425,419,537]	2	hSpCas9	negative selection	9022022
179201282	179201305	3	+	27260156	SU8686	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-0.10409989294583322	[231]	[255,201,178,212]	-2	hSpCas9	negative selection	9022023
179209682	179209705	3	-	27260156	SU8686	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.6780022692596048	[975]	[1412,1323,1515,2053]	9	hSpCas9	negative selection	9022024
179210228	179210251	3	+	27260156	SKES1	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	-0.05723426089441652	[1385]	[1523,1500,1266,1086]	-1	hSpCas9	negative selection	9079021
179210291	179210314	3	+	27260156	SKES1	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	-0.1603473646471072	[285]	[240,294,234,250]	-3	hSpCas9	negative selection	9079022
179201376	179201399	3	-	27260156	SKES1	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	0.20205588424578746	[205]	[308,340,114,205]	4	hSpCas9	negative selection	9079023
179209629	179209652	3	-	27260156	SKES1	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.20740159685740953	[425]	[470,303,380,323]	-4	hSpCas9	negative selection	9143273
179201282	179201305	3	+	27260156	SKES1	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-0.7098331002900002	[231]	[201,149,125,100]	-9	hSpCas9	negative selection	9143274
179209682	179209705	3	-	27260156	SKES1	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.376222093554168	[975]	[1497,1353,1175,1079]	7	hSpCas9	negative selection	9143275
179210228	179210251	3	+	27260156	TOV112D	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	0.05157945711675649	[1385]	[1710,2181,1054,1021]	1	hSpCas9	negative selection	9200272
179210291	179210314	3	+	27260156	TOV112D	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.1499340205398748	[285]	[441,354,271,223]	3	hSpCas9	negative selection	9200273
179201376	179201399	3	-	27260156	TOV112D	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	0.10146628505619071	[205]	[227,357,175,158]	2	hSpCas9	negative selection	9200274
179209629	179209652	3	-	27260156	TOV112D	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	0.12829819780304855	[425]	[412,370,526,523]	2	hSpCas9	negative selection	9264524
179201282	179201305	3	+	27260156	TOV112D	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	0.06976760118237757	[231]	[412,320,127,148]	1	hSpCas9	negative selection	9264525
179209682	179209705	3	-	27260156	TOV112D	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.49947890443632637	[975]	[1540,1361,1217,1411]	8	hSpCas9	negative selection	9264526
179210228	179210251	3	+	27260156	TC71	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	-0.056046245837743314	[1385]	[1311,1475,1365,1575]	-1	hSpCas9	negative selection	9321523
179210291	179210314	3	+	27260156	TC71	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.385367047106004	[285]	[398,391,354,460]	8	hSpCas9	negative selection	9321524
179201376	179201399	3	-	27260156	TC71	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.049670967585639936	[205]	[177,288,208,175]	-1	hSpCas9	negative selection	9321525
179209629	179209652	3	-	27260156	TC71	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.3352862262437638	[425]	[324,393,301,433]	-7	hSpCas9	negative selection	9385775
179201282	179201305	3	+	27260156	TC71	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-0.2593145715528542	[231]	[245,194,182,206]	-6	hSpCas9	negative selection	9385776
179209682	179209705	3	-	27260156	TC71	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.29603218145485366	[975]	[1223,1182,1293,1447]	7	hSpCas9	negative selection	9385777
179210228	179210251	3	+	27260156	TC32	viability	TACACAGACACTCTAGTATCTGG	PIK3CA	ENSG00000121879	-0.15448374371173412	[1385]	[1069,842,1632,1289]	-3	hSpCas9	negative selection	9442774
179210291	179210314	3	+	27260156	TC32	viability	GAAGATTTGCTGAACCCTATTGG	PIK3CA	ENSG00000121879	0.568529031666546	[285]	[331,370,531,374]	8	hSpCas9	negative selection	9442775
179201376	179201399	3	-	27260156	TC32	viability	GCTTCAGCAATTACTTGTTCTGG	PIK3CA	ENSG00000121879	-0.2578462059636144	[205]	[85,136,280,174]	-5	hSpCas9	negative selection	9442776
179209629	179209652	3	-	27260156	TC32	viability	CGAGCAGCACGAGGAAGATCAGG	PIK3CA	ENSG00000121879	-0.2459467459904384	[425]	[163,331,486,400]	-4	hSpCas9	negative selection	9507026
179201282	179201305	3	+	27260156	TC32	viability	TGTTATAGGGCAAATAATAGTGG	PIK3CA	ENSG00000121879	-0.5416146896635985	[231]	[159,109,223,120]	-8	hSpCas9	negative selection	9507027
179209682	179209705	3	-	27260156	TC32	viability	TTACCTCTTTAGCACCCTTTCGG	PIK3CA	ENSG00000121879	0.37287672583616227	[975]	[1039,1035,1394,1325]	6	hSpCas9	negative selection	9507028
179204572	179204595	3	-	27869803	HPAFII	viability after 27 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-2.036672242225142	[336]	[52,34,NaN]	-8	hSpCas9	negative selection	9583592
179209638	179209661	3	-	27869803	HPAFII	viability after 27 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	-4.002171099041627	[398]	[11,13,NaN]	-9	hSpCas9	negative selection	9583593
179209679	179209702	3	+	27869803	HPAFII	viability after 27 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	0.2392682150396488	[454]	[223,330,NaN]	2	hSpCas9	negative selection	9583594
179210518	179210541	3	+	27869803	HPAFII	viability after 27 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	-1.313863922045147	[327]	[40,92,NaN]	-7	hSpCas9	negative selection	9583595
179229305	179229328	3	+	27869803	HPAFII	viability after 27 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-1.5342417116865879	[603]	[89,125,NaN]	-7	hSpCas9	negative selection	9583596
179230022	179230045	3	-	27869803	HPAFII	viability after 27 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	1.5184036065181021	[334]	[353,629,NaN]	9	hSpCas9	negative selection	9583597
179204572	179204595	3	-	27869803	HPAFII	viability after 15 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-0.813336321571489	[336]	[268,166,NaN]	-7	hSpCas9	negative selection	9666041
179209638	179209661	3	-	27869803	HPAFII	viability after 15 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	-1.000705013142465	[398]	[254,188,NaN]	-7	hSpCas9	negative selection	9666042
179209679	179209702	3	+	27869803	HPAFII	viability after 15 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	0.4788915287327564	[454]	[773,623,NaN]	5	hSpCas9	negative selection	9666043
179210518	179210541	3	+	27869803	HPAFII	viability after 15 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	-0.1359149145114361	[327]	[334,311,NaN]	-2	hSpCas9	negative selection	9666044
179229305	179229328	3	+	27869803	HPAFII	viability after 15 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-1.6663222798945485	[603]	[177,220,NaN]	-9	hSpCas9	negative selection	9666045
179230022	179230045	3	-	27869803	HPAFII	viability after 15 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	0.821520466296559	[334]	[573,674,NaN]	8	hSpCas9	negative selection	9666046
179204572	179204595	3	-	27869803	ASPC1	viability after 36 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-0.6320115278482693	[1222]	[630,87,171]	-6	hSpCas9	negative selection	9748490
179209638	179209661	3	-	27869803	ASPC1	viability after 36 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	0.043414361251116085	[1013]	[296,542,266]	0	hSpCas9	negative selection	9748491
179209679	179209702	3	+	27869803	ASPC1	viability after 36 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	0.899589470998339	[1221]	[816,934,661]	8	hSpCas9	negative selection	9748492
179210518	179210541	3	+	27869803	ASPC1	viability after 36 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	-0.45875392728181613	[892]	[258,242,188]	-5	hSpCas9	negative selection	9748493
179229305	179229328	3	+	27869803	ASPC1	viability after 36 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-3.29014929777972	[1073]	[73,12,32]	-9	hSpCas9	negative selection	9748494
179230022	179230045	3	-	27869803	ASPC1	viability after 36 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	0.14501216927892158	[777]	[349,282,275]	1	hSpCas9	negative selection	9748495
179204572	179204595	3	-	27869803	PATU8988S	viability after 35 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-2.370084673764667	[1001]	[104,50,NaN]	-9	hSpCas9	negative selection	9830939
179209638	179209661	3	-	27869803	PATU8988S	viability after 35 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	-1.7853300593027115	[769]	[75,103,NaN]	-8	hSpCas9	negative selection	9830940
179209679	179209702	3	+	27869803	PATU8988S	viability after 35 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-0.6540821032751376	[869]	[295,148,NaN]	-6	hSpCas9	negative selection	9830941
179210518	179210541	3	+	27869803	PATU8988S	viability after 35 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	-0.6432379053627137	[691]	[154,201,NaN]	-6	hSpCas9	negative selection	9830942
179229305	179229328	3	+	27869803	PATU8988S	viability after 35 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-2.9028675896332503	[1130]	[18,102,NaN]	-9	hSpCas9	negative selection	9830943
179230022	179230045	3	-	27869803	PATU8988S	viability after 35 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	0.7721350397771595	[608]	[365,471,NaN]	7	hSpCas9	negative selection	9830944
179204572	179204595	3	-	27869803	PATU8988S	viability after 31 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-2.460328995396984	[1001]	[65,80,NaN]	-9	hSpCas9	negative selection	9913388
179209638	179209661	3	-	27869803	PATU8988S	viability after 31 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	-1.632527379022163	[769]	[25,191,NaN]	-8	hSpCas9	negative selection	9913389
179209679	179209702	3	+	27869803	PATU8988S	viability after 31 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	-0.9007237594558206	[869]	[231,126,NaN]	-7	hSpCas9	negative selection	9913390
179210518	179210541	3	+	27869803	PATU8988S	viability after 31 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	-0.46692435696532164	[691]	[185,216,NaN]	-5	hSpCas9	negative selection	9913391
179229305	179229328	3	+	27869803	PATU8988S	viability after 31 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-4.047321775793383	[1130]	[10,47,NaN]	-9	hSpCas9	negative selection	9913392
179230022	179230045	3	-	27869803	PATU8988S	viability after 31 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	0.5335729199771323	[608]	[281,439,NaN]	6	hSpCas9	negative selection	9913393
179204572	179204595	3	-	27869803	HPAFII	viability after 35 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-2.2850702960979414	[336]	[42,25,NaN]	-8	hSpCas9	negative selection	9995837
179209638	179209661	3	-	27869803	HPAFII	viability after 35 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	-5.0181830131294705	[398]	[1,10,NaN]	-9	hSpCas9	negative selection	9995838
179209679	179209702	3	+	27869803	HPAFII	viability after 35 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	0.49804717054425374	[454]	[242,417,NaN]	3	hSpCas9	negative selection	9995839
179210518	179210541	3	+	27869803	HPAFII	viability after 35 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	-1.8359980950219472	[327]	[6,90,NaN]	-7	hSpCas9	negative selection	9995840
179229305	179229328	3	+	27869803	HPAFII	viability after 35 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-2.07244057099279	[603]	[59,86,NaN]	-8	hSpCas9	negative selection	9995841
179230022	179230045	3	-	27869803	HPAFII	viability after 35 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	1.5114374501649954	[334]	[300,688,NaN]	8	hSpCas9	negative selection	9995842
179204572	179204595	3	-	27869803	HPAFII	viability after 31 days	CCTTACCTGGGATTGGAACAAGG	PIK3CA	ENSG00000121879	-2.0495623749712353	[336]	[60,28,NaN]	-8	hSpCas9	negative selection	10078286
179209638	179209661	3	-	27869803	HPAFII	viability after 31 days	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	-3.726703387863105	[398]	[14,18,NaN]	-9	hSpCas9	negative selection	10078287
179209679	179209702	3	+	27869803	HPAFII	viability after 31 days	AGGCCGAAAGGGTGCTAAAGAGG	PIK3CA	ENSG00000121879	0.45376978294743764	[454]	[287,416,NaN]	3	hSpCas9	negative selection	10078288
179210518	179210541	3	+	27869803	HPAFII	viability after 31 days	TGGTCTGTATCCCGAGAAGCAGG	PIK3CA	ENSG00000121879	-1.4934348565879798	[327]	[17,116,NaN]	-7	hSpCas9	negative selection	10078289
179229305	179229328	3	+	27869803	HPAFII	viability after 31 days	CTGTGTGGGACTTATTGAGGTGG	PIK3CA	ENSG00000121879	-2.35254311778598	[603]	[29,105,NaN]	-8	hSpCas9	negative selection	10078290
179230022	179230045	3	-	27869803	HPAFII	viability after 31 days	CAGCACATGAACGTGTAAACAGG	PIK3CA	ENSG00000121879	1.4689102720153009	[334]	[328,728,NaN]	9	hSpCas9	negative selection	10078291
179199769	179199792	3	+	28162770	P31FUJ	viability	GAACGTTTGTAAAGAAGCTGTGG	PIK3CA	ENSG00000121879	0.7500226517774894	[337]	[667]	8	hSpCas9	negative selection	10211327
179199727	179199750	3	+	28162770	P31FUJ	viability	GGTTAAAGATCCAGAAGTACAGG	PIK3CA	ENSG00000121879	-0.16065241865854313	[155]	[163]	-1	hSpCas9	negative selection	10211328
179210539	179210562	3	+	28162770	P31FUJ	viability	GGATTTAGCTATTCCCACGCAGG	PIK3CA	ENSG00000121879	0.6891952835843481	[341]	[647]	7	hSpCas9	negative selection	10211329
179229394	179229417	3	+	28162770	P31FUJ	viability	ACAGCCACACACTACATCAGTGG	PIK3CA	ENSG00000121879	0.14079057656711358	[564]	[731]	1	hSpCas9	negative selection	10211330
179198829	179198852	3	-	28162770	P31FUJ	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	0.3892797518674771	[242]	[373]	4	hSpCas9	negative selection	10211331
179198933	179198956	3	-	28162770	P31FUJ	viability	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	0.11761879230421335	[370]	[472]	1	hSpCas9	negative selection	10211332
179209638	179209661	3	-	28162770	P31FUJ	viability	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	0.13959888433002332	[454]	[588]	1	hSpCas9	negative selection	10211333
179210185	179210208	3	+	28162770	P31FUJ	viability	GGAACACTGTCCATTGGCATGGG	PIK3CA	ENSG00000121879	0.7240459571711204	[525]	[1020]	8	hSpCas9	negative selection	10211334
179210430	179210453	3	+	28162770	P31FUJ	viability	GGAAACTCCATGCTTAGAGTTGG	PIK3CA	ENSG00000121879	0.3796934800629226	[345]	[528]	4	hSpCas9	negative selection	10211335
179230095	179230118	3	+	28162770	P31FUJ	viability	AACATCATGGTGAAAGACGATGG	PIK3CA	ENSG00000121879	0.5991307403638912	[290]	[517]	6	hSpCas9	negative selection	10211336
179199769	179199792	3	+	28162770	TF1	viability	GAACGTTTGTAAAGAAGCTGTGG	PIK3CA	ENSG00000121879	NaN	[NaN]	[160]	1	hSpCas9	negative selection	10380693
179199727	179199750	3	+	28162770	TF1	viability	GGTTAAAGATCCAGAAGTACAGG	PIK3CA	ENSG00000121879	NaN	[NaN]	[132]	1	hSpCas9	negative selection	10380694
179210539	179210562	3	+	28162770	TF1	viability	GGATTTAGCTATTCCCACGCAGG	PIK3CA	ENSG00000121879	NaN	[NaN]	[135]	1	hSpCas9	negative selection	10380695
179229394	179229417	3	+	28162770	TF1	viability	ACAGCCACACACTACATCAGTGG	PIK3CA	ENSG00000121879	NaN	[NaN]	[350]	1	hSpCas9	negative selection	10380696
179198829	179198852	3	-	28162770	TF1	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	NaN	[NaN]	[326]	1	hSpCas9	negative selection	10380697
179198933	179198956	3	-	28162770	TF1	viability	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	NaN	[NaN]	[242]	1	hSpCas9	negative selection	10380698
179209638	179209661	3	-	28162770	TF1	viability	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	NaN	[NaN]	[340]	1	hSpCas9	negative selection	10380699
179210185	179210208	3	+	28162770	TF1	viability	GGAACACTGTCCATTGGCATGGG	PIK3CA	ENSG00000121879	NaN	[NaN]	[382]	1	hSpCas9	negative selection	10380700
179210430	179210453	3	+	28162770	TF1	viability	GGAAACTCCATGCTTAGAGTTGG	PIK3CA	ENSG00000121879	NaN	[NaN]	[177]	1	hSpCas9	negative selection	10380701
179230095	179230118	3	+	28162770	TF1	viability	AACATCATGGTGAAAGACGATGG	PIK3CA	ENSG00000121879	NaN	[NaN]	[181]	1	hSpCas9	negative selection	10380702
179199769	179199792	3	+	28162770	SKM1	viability	GAACGTTTGTAAAGAAGCTGTGG	PIK3CA	ENSG00000121879	0.550552469935325	[111]	[289]	5	hSpCas9	negative selection	10550059
179199727	179199750	3	+	28162770	SKM1	viability	GGTTAAAGATCCAGAAGTACAGG	PIK3CA	ENSG00000121879	1.2324460860003708	[25]	[107]	9	hSpCas9	negative selection	10550060
179210539	179210562	3	+	28162770	SKM1	viability	GGATTTAGCTATTCCCACGCAGG	PIK3CA	ENSG00000121879	-0.15345256702787435	[94]	[150]	-1	hSpCas9	negative selection	10550061
179229394	179229417	3	+	28162770	SKM1	viability	ACAGCCACACACTACATCAGTGG	PIK3CA	ENSG00000121879	-0.7301628309569288	[212]	[226]	-5	hSpCas9	negative selection	10550062
179198829	179198852	3	-	28162770	SKM1	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	0.42717005443004286	[60]	[144]	4	hSpCas9	negative selection	10550063
179198933	179198956	3	-	28162770	SKM1	viability	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-1.0825292482452245	[114]	[95]	-7	hSpCas9	negative selection	10550064
179209638	179209661	3	-	28162770	SKM1	viability	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	-0.37012743056279035	[86]	[118]	-3	hSpCas9	negative selection	10550065
179210185	179210208	3	+	28162770	SKM1	viability	GGAACACTGTCCATTGGCATGGG	PIK3CA	ENSG00000121879	0.7400966943474137	[105]	[312]	7	hSpCas9	negative selection	10550066
179210430	179210453	3	+	28162770	SKM1	viability	GGAAACTCCATGCTTAGAGTTGG	PIK3CA	ENSG00000121879	0.8933574399548256	[73]	[242]	8	hSpCas9	negative selection	10550067
179230095	179230118	3	+	28162770	SKM1	viability	AACATCATGGTGAAAGACGATGG	PIK3CA	ENSG00000121879	-0.14053121644750294	[52]	[84]	-1	hSpCas9	negative selection	10550068
179199769	179199792	3	+	28162770	SKM1	viability	GAACGTTTGTAAAGAAGCTGTGG	PIK3CA	ENSG00000121879	0.550552469935325	[111]	[289]	5	hSpCas9	negative selection	10719425
179199727	179199750	3	+	28162770	SKM1	viability	GGTTAAAGATCCAGAAGTACAGG	PIK3CA	ENSG00000121879	1.2324460860003708	[25]	[107]	9	hSpCas9	negative selection	10719426
179210539	179210562	3	+	28162770	SKM1	viability	GGATTTAGCTATTCCCACGCAGG	PIK3CA	ENSG00000121879	-0.15345256702787435	[94]	[150]	-1	hSpCas9	negative selection	10719427
179229394	179229417	3	+	28162770	SKM1	viability	ACAGCCACACACTACATCAGTGG	PIK3CA	ENSG00000121879	-0.7301628309569288	[212]	[226]	-5	hSpCas9	negative selection	10719428
179198829	179198852	3	-	28162770	SKM1	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	0.42717005443004286	[60]	[144]	4	hSpCas9	negative selection	10719429
179198933	179198956	3	-	28162770	SKM1	viability	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-1.0825292482452245	[114]	[95]	-7	hSpCas9	negative selection	10719430
179209638	179209661	3	-	28162770	SKM1	viability	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	-0.37012743056279035	[86]	[118]	-3	hSpCas9	negative selection	10719431
179210185	179210208	3	+	28162770	SKM1	viability	GGAACACTGTCCATTGGCATGGG	PIK3CA	ENSG00000121879	0.7400966943474137	[105]	[312]	7	hSpCas9	negative selection	10719432
179210430	179210453	3	+	28162770	SKM1	viability	GGAAACTCCATGCTTAGAGTTGG	PIK3CA	ENSG00000121879	0.8933574399548256	[73]	[242]	8	hSpCas9	negative selection	10719433
179230095	179230118	3	+	28162770	SKM1	viability	AACATCATGGTGAAAGACGATGG	PIK3CA	ENSG00000121879	-0.14053121644750294	[52]	[84]	-1	hSpCas9	negative selection	10719434
179199769	179199792	3	+	28162770	PL21	viability	GAACGTTTGTAAAGAAGCTGTGG	PIK3CA	ENSG00000121879	-0.1690941951763988	[402]	[155]	-1	hSpCas9	negative selection	10888791
179199727	179199750	3	+	28162770	PL21	viability	GGTTAAAGATCCAGAAGTACAGG	PIK3CA	ENSG00000121879	0.44437642486898793	[102]	[60]	4	hSpCas9	negative selection	10888792
179210539	179210562	3	+	28162770	PL21	viability	GGATTTAGCTATTCCCACGCAGG	PIK3CA	ENSG00000121879	0.3804714309928644	[352]	[199]	3	hSpCas9	negative selection	10888793
179229394	179229417	3	+	28162770	PL21	viability	ACAGCCACACACTACATCAGTGG	PIK3CA	ENSG00000121879	-0.20925132164838178	[764]	[287]	-1	hSpCas9	negative selection	10888794
179198829	179198852	3	-	28162770	PL21	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	0.7681290366067627	[227]	[168]	6	hSpCas9	negative selection	10888795
179198933	179198956	3	-	28162770	PL21	viability	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-0.2804862264171003	[359]	[128]	-2	hSpCas9	negative selection	10888796
179209638	179209661	3	-	28162770	PL21	viability	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	0.7653700500862919	[318]	[235]	6	hSpCas9	negative selection	10888797
179210185	179210208	3	+	28162770	PL21	viability	GGAACACTGTCCATTGGCATGGG	PIK3CA	ENSG00000121879	-0.17772665199189985	[446]	[171]	-1	hSpCas9	negative selection	10888798
179210430	179210453	3	+	28162770	PL21	viability	GGAAACTCCATGCTTAGAGTTGG	PIK3CA	ENSG00000121879	0.8811892194018532	[241]	[193]	7	hSpCas9	negative selection	10888799
179230095	179230118	3	+	28162770	PL21	viability	AACATCATGGTGAAAGACGATGG	PIK3CA	ENSG00000121879	-0.7789007668750337	[204]	[51]	-5	hSpCas9	negative selection	10888800
179199769	179199792	3	+	28162770	P31FUJ	viability	GAACGTTTGTAAAGAAGCTGTGG	PIK3CA	ENSG00000121879	0.7500226517774894	[337]	[667]	8	hSpCas9	negative selection	11058157
179199727	179199750	3	+	28162770	P31FUJ	viability	GGTTAAAGATCCAGAAGTACAGG	PIK3CA	ENSG00000121879	-0.16065241865854313	[155]	[163]	-1	hSpCas9	negative selection	11058158
179210539	179210562	3	+	28162770	P31FUJ	viability	GGATTTAGCTATTCCCACGCAGG	PIK3CA	ENSG00000121879	0.6891952835843481	[341]	[647]	7	hSpCas9	negative selection	11058159
179229394	179229417	3	+	28162770	P31FUJ	viability	ACAGCCACACACTACATCAGTGG	PIK3CA	ENSG00000121879	0.14079057656711358	[564]	[731]	1	hSpCas9	negative selection	11058160
179198829	179198852	3	-	28162770	P31FUJ	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	0.3892797518674771	[242]	[373]	4	hSpCas9	negative selection	11058161
179198933	179198956	3	-	28162770	P31FUJ	viability	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	0.11761879230421335	[370]	[472]	1	hSpCas9	negative selection	11058162
179209638	179209661	3	-	28162770	P31FUJ	viability	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	0.13959888433002332	[454]	[588]	1	hSpCas9	negative selection	11058163
179210185	179210208	3	+	28162770	P31FUJ	viability	GGAACACTGTCCATTGGCATGGG	PIK3CA	ENSG00000121879	0.7240459571711204	[525]	[1020]	8	hSpCas9	negative selection	11058164
179210430	179210453	3	+	28162770	P31FUJ	viability	GGAAACTCCATGCTTAGAGTTGG	PIK3CA	ENSG00000121879	0.3796934800629226	[345]	[528]	4	hSpCas9	negative selection	11058165
179230095	179230118	3	+	28162770	P31FUJ	viability	AACATCATGGTGAAAGACGATGG	PIK3CA	ENSG00000121879	0.5991307403638912	[290]	[517]	6	hSpCas9	negative selection	11058166
179199769	179199792	3	+	28162770	OCIAML5	viability	GAACGTTTGTAAAGAAGCTGTGG	PIK3CA	ENSG00000121879	0.7556160063572427	[188]	[575]	6	hSpCas9	negative selection	11227523
179199727	179199750	3	+	28162770	OCIAML5	viability	GGTTAAAGATCCAGAAGTACAGG	PIK3CA	ENSG00000121879	0.3142918155581232	[89]	[201]	2	hSpCas9	negative selection	11227524
179210539	179210562	3	+	28162770	OCIAML5	viability	GGATTTAGCTATTCCCACGCAGG	PIK3CA	ENSG00000121879	0.861882370577237	[138]	[455]	7	hSpCas9	negative selection	11227525
179229394	179229417	3	+	28162770	OCIAML5	viability	ACAGCCACACACTACATCAGTGG	PIK3CA	ENSG00000121879	-0.05888496713124258	[452]	[784]	0	hSpCas9	negative selection	11227526
179198829	179198852	3	-	28162770	OCIAML5	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	0.2667195815865143	[133]	[290]	2	hSpCas9	negative selection	11227527
179198933	179198956	3	-	28162770	OCIAML5	viability	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	0.26736866012462235	[167]	[364]	2	hSpCas9	negative selection	11227528
179209638	179209661	3	-	28162770	OCIAML5	viability	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	0.46986152402336545	[139]	[349]	4	hSpCas9	negative selection	11227529
179210185	179210208	3	+	28162770	OCIAML5	viability	GGAACACTGTCCATTGGCATGGG	PIK3CA	ENSG00000121879	0.28630239684763725	[302]	[666]	2	hSpCas9	negative selection	11227530
179210430	179210453	3	+	28162770	OCIAML5	viability	GGAAACTCCATGCTTAGAGTTGG	PIK3CA	ENSG00000121879	0.6363879490038128	[169]	[476]	5	hSpCas9	negative selection	11227531
179230095	179230118	3	+	28162770	OCIAML5	viability	AACATCATGGTGAAAGACGATGG	PIK3CA	ENSG00000121879	0.41096783496979683	[139]	[335]	3	hSpCas9	negative selection	11227532
179199769	179199792	3	+	28162770	EOL1	viability	GAACGTTTGTAAAGAAGCTGTGG	PIK3CA	ENSG00000121879	-0.5441868508880624	[738]	[266]	-4	hSpCas9	negative selection	11396889
179199727	179199750	3	+	28162770	EOL1	viability	GGTTAAAGATCCAGAAGTACAGG	PIK3CA	ENSG00000121879	-0.4611059209272148	[161]	[61]	-3	hSpCas9	negative selection	11396890
179210539	179210562	3	+	28162770	EOL1	viability	GGATTTAGCTATTCCCACGCAGG	PIK3CA	ENSG00000121879	0.05007865365439357	[626]	[341]	0	hSpCas9	negative selection	11396891
179229394	179229417	3	+	28162770	EOL1	viability	ACAGCCACACACTACATCAGTGG	PIK3CA	ENSG00000121879	-0.46280616902259486	[1341]	[512]	-3	hSpCas9	negative selection	11396892
179198829	179198852	3	-	28162770	EOL1	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	0.375462307177975	[416]	[284]	3	hSpCas9	negative selection	11396893
179198933	179198956	3	-	28162770	EOL1	viability	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-0.2646472568020948	[715]	[313]	-2	hSpCas9	negative selection	11396894
179209638	179209661	3	-	28162770	EOL1	viability	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	0.7801578622353595	[377]	[341]	7	hSpCas9	negative selection	11396895
179210185	179210208	3	+	28162770	EOL1	viability	GGAACACTGTCCATTGGCATGGG	PIK3CA	ENSG00000121879	1.0133570385283905	[503]	[535]	8	hSpCas9	negative selection	11396896
179210430	179210453	3	+	28162770	EOL1	viability	GGAAACTCCATGCTTAGAGTTGG	PIK3CA	ENSG00000121879	-0.2874280338205751	[321]	[138]	-2	hSpCas9	negative selection	11396897
179230095	179230118	3	+	28162770	EOL1	viability	AACATCATGGTGAAAGACGATGG	PIK3CA	ENSG00000121879	0.2140543887655195	[233]	[142]	2	hSpCas9	negative selection	11396898
179199769	179199792	3	+	28162770	MOLM13	viability	GAACGTTTGTAAAGAAGCTGTGG	PIK3CA	ENSG00000121879	0.5038462593209885	[633]	[649]	4	hSpCas9	negative selection	11566255
179199727	179199750	3	+	28162770	MOLM13	viability	GGTTAAAGATCCAGAAGTACAGG	PIK3CA	ENSG00000121879	0.07397517383148894	[225]	[171]	0	hSpCas9	negative selection	11566256
179210539	179210562	3	+	28162770	MOLM13	viability	GGATTTAGCTATTCCCACGCAGG	PIK3CA	ENSG00000121879	1.0791503691350681	[452]	[691]	7	hSpCas9	negative selection	11566257
179229394	179229417	3	+	28162770	MOLM13	viability	ACAGCCACACACTACATCAGTGG	PIK3CA	ENSG00000121879	0.21003521481646503	[1111]	[929]	1	hSpCas9	negative selection	11566258
179198829	179198852	3	-	28162770	MOLM13	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	0.01858198018098873	[283]	[207]	0	hSpCas9	negative selection	11566259
179198933	179198956	3	-	28162770	MOLM13	viability	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	0.590484972603891	[450]	[490]	4	hSpCas9	negative selection	11566260
179209638	179209661	3	-	28162770	MOLM13	viability	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	0.3693611766385787	[408]	[381]	2	hSpCas9	negative selection	11566261
179210185	179210208	3	+	28162770	MOLM13	viability	GGAACACTGTCCATTGGCATGGG	PIK3CA	ENSG00000121879	0.09663357429364794	[594]	[459]	0	hSpCas9	negative selection	11566262
179210430	179210453	3	+	28162770	MOLM13	viability	GGAAACTCCATGCTTAGAGTTGG	PIK3CA	ENSG00000121879	-0.1876346166535831	[418]	[265]	-1	hSpCas9	negative selection	11566263
179230095	179230118	3	+	28162770	MOLM13	viability	AACATCATGGTGAAAGACGATGG	PIK3CA	ENSG00000121879	-0.06630450843511182	[348]	[240]	0	hSpCas9	negative selection	11566264
179199769	179199792	3	+	28162770	HEL	viability	GAACGTTTGTAAAGAAGCTGTGG	PIK3CA	ENSG00000121879	0.8521076143301948	[460]	[532]	7	hSpCas9	negative selection	11735621
179199727	179199750	3	+	28162770	HEL	viability	GGTTAAAGATCCAGAAGTACAGG	PIK3CA	ENSG00000121879	-0.3486480376949349	[166]	[83]	-2	hSpCas9	negative selection	11735622
179210539	179210562	3	+	28162770	HEL	viability	GGATTTAGCTATTCCCACGCAGG	PIK3CA	ENSG00000121879	0.25627048491828397	[399]	[305]	2	hSpCas9	negative selection	11735623
179229394	179229417	3	+	28162770	HEL	viability	ACAGCCACACACTACATCAGTGG	PIK3CA	ENSG00000121879	-0.363848828034403	[877]	[436]	-3	hSpCas9	negative selection	11735624
179198829	179198852	3	-	28162770	HEL	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	1.0631898274655653	[265]	[355]	8	hSpCas9	negative selection	11735625
179198933	179198956	3	-	28162770	HEL	viability	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	0.12687427160931142	[478]	[334]	1	hSpCas9	negative selection	11735626
179209638	179209661	3	-	28162770	HEL	viability	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	0.49589744367108585	[309]	[279]	4	hSpCas9	negative selection	11735627
179210185	179210208	3	+	28162770	HEL	viability	GGAACACTGTCCATTGGCATGGG	PIK3CA	ENSG00000121879	0.15670950115007454	[478]	[341]	1	hSpCas9	negative selection	11735628
179210430	179210453	3	+	28162770	HEL	viability	GGAAACTCCATGCTTAGAGTTGG	PIK3CA	ENSG00000121879	0.13623756984741942	[330]	[232]	1	hSpCas9	negative selection	11735629
179230095	179230118	3	+	28162770	HEL	viability	AACATCATGGTGAAAGACGATGG	PIK3CA	ENSG00000121879	-0.6064329204516912	[289]	[121]	-4	hSpCas9	negative selection	11735630
179199769	179199792	3	+	28162770	MV411	viability	GAACGTTTGTAAAGAAGCTGTGG	PIK3CA	ENSG00000121879	-0.029333468864927603	[400]	[330]	0	hSpCas9	negative selection	11904987
179199727	179199750	3	+	28162770	MV411	viability	GGTTAAAGATCCAGAAGTACAGG	PIK3CA	ENSG00000121879	-0.4783874857782304	[85]	[51]	-4	hSpCas9	negative selection	11904988
179210539	179210562	3	+	28162770	MV411	viability	GGATTTAGCTATTCCCACGCAGG	PIK3CA	ENSG00000121879	0.32481239471198187	[362]	[382]	3	hSpCas9	negative selection	11904989
179229394	179229417	3	+	28162770	MV411	viability	ACAGCCACACACTACATCAGTGG	PIK3CA	ENSG00000121879	-0.3375249499383808	[800]	[533]	-3	hSpCas9	negative selection	11904990
179198829	179198852	3	-	28162770	MV411	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	-0.24540674794994938	[272]	[193]	-2	hSpCas9	negative selection	11904991
179198933	179198956	3	-	28162770	MV411	viability	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	0.33173578508943513	[348]	[369]	3	hSpCas9	negative selection	11904992
179209638	179209661	3	-	28162770	MV411	viability	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	1.4345889663356841	[295]	[673]	9	hSpCas9	negative selection	11904993
179210185	179210208	3	+	28162770	MV411	viability	GGAACACTGTCCATTGGCATGGG	PIK3CA	ENSG00000121879	0.632427913419831	[375]	[490]	6	hSpCas9	negative selection	11904994
179210430	179210453	3	+	28162770	MV411	viability	GGAAACTCCATGCTTAGAGTTGG	PIK3CA	ENSG00000121879	0.9358514001168718	[277]	[447]	8	hSpCas9	negative selection	11904995
179230095	179230118	3	+	28162770	MV411	viability	AACATCATGGTGAAAGACGATGG	PIK3CA	ENSG00000121879	-0.4654643384929614	[217]	[132]	-3	hSpCas9	negative selection	11904996
179199769	179199792	3	+	28162770	MONOMAC1	viability	GAACGTTTGTAAAGAAGCTGTGG	PIK3CA	ENSG00000121879	-0.19134573498169805	[252]	[253]	-2	hSpCas9	negative selection	12074353
179199727	179199750	3	+	28162770	MONOMAC1	viability	GGTTAAAGATCCAGAAGTACAGG	PIK3CA	ENSG00000121879	-0.6390413939386669	[71]	[52]	-5	hSpCas9	negative selection	12074354
179210539	179210562	3	+	28162770	MONOMAC1	viability	GGATTTAGCTATTCCCACGCAGG	PIK3CA	ENSG00000121879	-0.20936764897027316	[234]	[232]	-2	hSpCas9	negative selection	12074355
179229394	179229417	3	+	28162770	MONOMAC1	viability	ACAGCCACACACTACATCAGTGG	PIK3CA	ENSG00000121879	0.04906716282436285	[499]	[592]	0	hSpCas9	negative selection	12074356
179198829	179198852	3	-	28162770	MONOMAC1	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	-0.6609839468193439	[119]	[86]	-5	hSpCas9	negative selection	12074357
179198933	179198956	3	-	28162770	MONOMAC1	viability	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	0.004343040860450342	[246]	[283]	0	hSpCas9	negative selection	12074358
179209638	179209661	3	-	28162770	MONOMAC1	viability	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	0.39857289786111094	[179]	[271]	4	hSpCas9	negative selection	12074359
179210185	179210208	3	+	28162770	MONOMAC1	viability	GGAACACTGTCCATTGGCATGGG	PIK3CA	ENSG00000121879	-0.35824941716529235	[226]	[202]	-3	hSpCas9	negative selection	12074360
179210430	179210453	3	+	28162770	MONOMAC1	viability	GGAAACTCCATGCTTAGAGTTGG	PIK3CA	ENSG00000121879	0.3849723362722551	[162]	[243]	4	hSpCas9	negative selection	12074361
179230095	179230118	3	+	28162770	MONOMAC1	viability	AACATCATGGTGAAAGACGATGG	PIK3CA	ENSG00000121879	0.6700688824431007	[124]	[227]	6	hSpCas9	negative selection	12074362
179199769	179199792	3	+	28162770	OCIAML2	viability	GAACGTTTGTAAAGAAGCTGTGG	PIK3CA	ENSG00000121879	0.9864578529268367	[55]	[614]	8	hSpCas9	negative selection	12243719
179199727	179199750	3	+	28162770	OCIAML2	viability	GGTTAAAGATCCAGAAGTACAGG	PIK3CA	ENSG00000121879	1.0383838222456963	[12]	[147]	8	hSpCas9	negative selection	12243720
179210539	179210562	3	+	28162770	OCIAML2	viability	GGATTTAGCTATTCCCACGCAGG	PIK3CA	ENSG00000121879	0.0276210422856642	[59]	[338]	0	hSpCas9	negative selection	12243721
179229394	179229417	3	+	28162770	OCIAML2	viability	ACAGCCACACACTACATCAGTGG	PIK3CA	ENSG00000121879	-0.33665152020624034	[148]	[653]	-3	hSpCas9	negative selection	12243722
179198829	179198852	3	-	28162770	OCIAML2	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	0.30277776489210506	[42]	[293]	3	hSpCas9	negative selection	12243723
179198933	179198956	3	-	28162770	OCIAML2	viability	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-0.28458515843657173	[88]	[404]	-2	hSpCas9	negative selection	12243724
179209638	179209661	3	-	28162770	OCIAML2	viability	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	0.16236537190079636	[63]	[396]	1	hSpCas9	negative selection	12243725
179210185	179210208	3	+	28162770	OCIAML2	viability	GGAACACTGTCCATTGGCATGGG	PIK3CA	ENSG00000121879	0.8992882125800346	[67]	[702]	8	hSpCas9	negative selection	12243726
179210430	179210453	3	+	28162770	OCIAML2	viability	GGAAACTCCATGCTTAGAGTTGG	PIK3CA	ENSG00000121879	0.8381228808974679	[43]	[435]	7	hSpCas9	negative selection	12243727
179230095	179230118	3	+	28162770	OCIAML2	viability	AACATCATGGTGAAAGACGATGG	PIK3CA	ENSG00000121879	-0.24646177901586191	[57]	[270]	-2	hSpCas9	negative selection	12243728
179199769	179199792	3	+	28162770	OCIAML3	viability	GAACGTTTGTAAAGAAGCTGTGG	PIK3CA	ENSG00000121879	0.42747208708628837	[99]	[405]	4	hSpCas9	negative selection	12413085
179199727	179199750	3	+	28162770	OCIAML3	viability	GGTTAAAGATCCAGAAGTACAGG	PIK3CA	ENSG00000121879	-0.4636110030684881	[36]	[80]	-4	hSpCas9	negative selection	12413086
179210539	179210562	3	+	28162770	OCIAML3	viability	GGATTTAGCTATTCCCACGCAGG	PIK3CA	ENSG00000121879	0.5947540031310046	[92]	[423]	5	hSpCas9	negative selection	12413087
179229394	179229417	3	+	28162770	OCIAML3	viability	ACAGCCACACACTACATCAGTGG	PIK3CA	ENSG00000121879	-0.04948606563150415	[204]	[597]	0	hSpCas9	negative selection	12413088
179198829	179198852	3	-	28162770	OCIAML3	viability	TCACCTGATGATGGTCGTGGAGG	PIK3CA	ENSG00000121879	1.5336256394017105	[49]	[436]	9	hSpCas9	negative selection	12413089
179198933	179198956	3	-	28162770	OCIAML3	viability	TTATTAATGTAGCCTCACGGAGG	PIK3CA	ENSG00000121879	-1.0603256445467004	[104]	[151]	-6	hSpCas9	negative selection	12413090
179209638	179209661	3	-	28162770	OCIAML3	viability	AGGCAAAGTCGAGCAGCACGAGG	PIK3CA	ENSG00000121879	0.6105072902820288	[86]	[400]	5	hSpCas9	negative selection	12413091
179210185	179210208	3	+	28162770	OCIAML3	viability	GGAACACTGTCCATTGGCATGGG	PIK3CA	ENSG00000121879	0.4561158391016733	[98]	[409]	4	hSpCas9	negative selection	12413092
179210430	179210453	3	+	28162770	OCIAML3	viability	GGAAACTCCATGCTTAGAGTTGG	PIK3CA	ENSG00000121879	-0.02369191556740824	[65]	[195]	0	hSpCas9	negative selection	12413093
179230095	179230118	3	+	28162770	OCIAML3	viability	AACATCATGGTGAAAGACGATGG	PIK3CA	ENSG00000121879	0.4550869092040064	[64]	[268]	4	hSpCas9	negative selection	12413094