Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:8503
• Symbol:PIK3R3
• Description:phosphoinositide-3-kinase regulatory subunit 3

DataSource: http://genomecrispr.dkfz.de/#!/results/PIK3R3

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
46066989	46067012	1	+	26472758	Jiyoye	viability	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	0.4071753815058732	[337]	[337]	3	hSpCas9	negative selection	120778
46067083	46067106	1	-	26472758	Jiyoye	viability	CTTGTTGTTCACAGGAAGGGAGG	PIK3R3	ENSG00000278139	0.7490949515807017	[85]	[108]	5	hSpCas9	negative selection	120779
46131935	46131958	1	-	26472758	Jiyoye	viability	GCGCGATGTACAATACGGTGTGG	PIK3R3	ENSG00000278139	0.017608569743147784	[130]	[99]	0	hSpCas9	negative selection	120780
46131905	46131928	1	-	26472758	Jiyoye	viability	ACCGCGATGACGCAGACTGGAGG	PIK3R3	ENSG00000278139	1.3448911032515307	[70]	[135]	7	hSpCas9	negative selection	120781
46045997	46046020	1	-	26472758	Jiyoye	viability	TATCAATCGAGTACAAGCAGAGG	PIK3R3	ENSG00000278139	0.18768869134483634	[247]	[212]	1	hSpCas9	negative selection	120782
46080694	46080717	1	-	26472758	Jiyoye	viability	AGCAGTTCCAAATGGAATGAAGG	PIK3R3	ENSG00000278139	0.46022161586750787	[266]	[276]	3	hSpCas9	negative selection	120783
46067047	46067070	1	-	26472758	Jiyoye	viability	ATAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	-0.14536564152290532	[65]	[44]	-1	hSpCas9	negative selection	120784
46067003	46067026	1	-	26472758	Jiyoye	viability	TCTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	-0.7977560697643523	[218]	[94]	-5	hSpCas9	negative selection	120785
46066970	46066993	1	+	26472758	Jiyoye	viability	CAAGAGATTCATGGTGATAGTGG	PIK3R3	ENSG00000278139	0.08849294612216507	[443]	[355]	0	hSpCas9	negative selection	120786
46046576	46046599	1	-	26472758	Jiyoye	viability	GAAACGCCTGAATGTCTGGCTGG	PIK3R3	ENSG00000278139	-0.2524844864928839	[217]	[137]	-2	hSpCas9	negative selection	120787
46066989	46067012	1	+	26472758	KBM7	viability	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	0.4094773893908126	[1517,1176]	[839,829]	4	hSpCas9	negative selection	311896
46067083	46067106	1	-	26472758	KBM7	viability	CTTGTTGTTCACAGGAAGGGAGG	PIK3R3	ENSG00000278139	0.010903783599556849	[441,268]	[267,72]	0	hSpCas9	negative selection	311897
46131935	46131958	1	-	26472758	KBM7	viability	GCGCGATGTACAATACGGTGTGG	PIK3R3	ENSG00000278139	0.40004879038029545	[685,613]	[516,300]	4	hSpCas9	negative selection	311898
46131905	46131928	1	-	26472758	KBM7	viability	ACCGCGATGACGCAGACTGGAGG	PIK3R3	ENSG00000278139	0.04974559411947599	[610,567]	[282,290]	0	hSpCas9	negative selection	311899
46045997	46046020	1	-	26472758	KBM7	viability	TATCAATCGAGTACAAGCAGAGG	PIK3R3	ENSG00000278139	0.44662098681371065	[764,908]	[615,478]	5	hSpCas9	negative selection	311900
46080694	46080717	1	-	26472758	KBM7	viability	AGCAGTTCCAAATGGAATGAAGG	PIK3R3	ENSG00000278139	0.8935574774661501	[1348,903]	[1272,696]	8	hSpCas9	negative selection	311901
46067047	46067070	1	-	26472758	KBM7	viability	ATAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.6171778574248123	[277,268]	[152,237]	6	hSpCas9	negative selection	311902
46067003	46067026	1	-	26472758	KBM7	viability	TCTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	-0.4034037764872183	[404,491]	[108,208]	-4	hSpCas9	negative selection	311903
46066970	46066993	1	+	26472758	KBM7	viability	CAAGAGATTCATGGTGATAGTGG	PIK3R3	ENSG00000278139	0.028098299266602123	[1581,1622]	[913,646]	0	hSpCas9	negative selection	311904
46046576	46046599	1	-	26472758	KBM7	viability	GAAACGCCTGAATGTCTGGCTGG	PIK3R3	ENSG00000278139	0.905942364887287	[791,596]	[519,682]	8	hSpCas9	negative selection	311905
46066989	46067012	1	+	26472758	Raji	viability	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	0.49528490471492903	[482]	[157]	5	hSpCas9	negative selection	503014
46067083	46067106	1	-	26472758	Raji	viability	CTTGTTGTTCACAGGAAGGGAGG	PIK3R3	ENSG00000278139	1.3493563256795638	[114]	[67]	9	hSpCas9	negative selection	503015
46131935	46131958	1	-	26472758	Raji	viability	GCGCGATGTACAATACGGTGTGG	PIK3R3	ENSG00000278139	0.3164791340965897	[217]	[62]	3	hSpCas9	negative selection	503016
46131905	46131928	1	-	26472758	Raji	viability	ACCGCGATGACGCAGACTGGAGG	PIK3R3	ENSG00000278139	1.637063600593566	[132]	[95]	9	hSpCas9	negative selection	503017
46045997	46046020	1	-	26472758	Raji	viability	TATCAATCGAGTACAAGCAGAGG	PIK3R3	ENSG00000278139	0.21645523452106918	[381]	[102]	2	hSpCas9	negative selection	503018
46080694	46080717	1	-	26472758	Raji	viability	AGCAGTTCCAAATGGAATGAAGG	PIK3R3	ENSG00000278139	0.3827487431181129	[465]	[140]	3	hSpCas9	negative selection	503019
46067047	46067070	1	-	26472758	Raji	viability	ATAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	-0.8879850158947546	[310]	[38]	-6	hSpCas9	negative selection	503020
46067003	46067026	1	-	26472758	Raji	viability	TCTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	-0.40357838390377987	[284]	[49]	-3	hSpCas9	negative selection	503021
46066970	46066993	1	+	26472758	Raji	viability	CAAGAGATTCATGGTGATAGTGG	PIK3R3	ENSG00000278139	-0.3602685900686664	[967]	[174]	-3	hSpCas9	negative selection	503022
46046576	46046599	1	-	26472758	Raji	viability	GAAACGCCTGAATGTCTGGCTGG	PIK3R3	ENSG00000278139	0.573270176148196	[222]	[76]	5	hSpCas9	negative selection	503023
46066989	46067012	1	+	26472758	K562	viability	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	-0.22448564359113266	[954]	[689]	-1	hSpCas9	negative selection	694132
46067083	46067106	1	-	26472758	K562	viability	CTTGTTGTTCACAGGAAGGGAGG	PIK3R3	ENSG00000278139	-0.5366862952333321	[353]	[205]	-3	hSpCas9	negative selection	694133
46131935	46131958	1	-	26472758	K562	viability	GCGCGATGTACAATACGGTGTGG	PIK3R3	ENSG00000278139	1.4468831559522375	[301]	[694]	9	hSpCas9	negative selection	694134
46131905	46131928	1	-	26472758	K562	viability	ACCGCGATGACGCAGACTGGAGG	PIK3R3	ENSG00000278139	-0.25578615487507417	[470]	[332]	-2	hSpCas9	negative selection	694135
46045997	46046020	1	-	26472758	K562	viability	TATCAATCGAGTACAAGCAGAGG	PIK3R3	ENSG00000278139	-0.16860242601389241	[714]	[536]	-1	hSpCas9	negative selection	694136
46080694	46080717	1	-	26472758	K562	viability	AGCAGTTCCAAATGGAATGAAGG	PIK3R3	ENSG00000278139	0.9607461517890856	[1041]	[1711]	7	hSpCas9	negative selection	694137
46067047	46067070	1	-	26472758	K562	viability	ATAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.6346010382590153	[321]	[421]	5	hSpCas9	negative selection	694138
46067003	46067026	1	-	26472758	K562	viability	TCTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	0.20578606806338723	[491]	[478]	1	hSpCas9	negative selection	694139
46066970	46066993	1	+	26472758	K562	viability	CAAGAGATTCATGGTGATAGTGG	PIK3R3	ENSG00000278139	1.3643793517073597	[1383]	[3007]	9	hSpCas9	negative selection	694140
46046576	46046599	1	-	26472758	K562	viability	GAAACGCCTGAATGTCTGGCTGG	PIK3R3	ENSG00000278139	0.8371168771672084	[495]	[747]	7	hSpCas9	negative selection	694141
46055805	46055828	1	+	26627737	DLD1	viability	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	-0.3169560145068484	[209]	[30,68,57]	-3	hSpCas9	negative selection	771755
46061949	46061972	1	-	26627737	DLD1	viability	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	0.47137686456023137	[636]	[257,317,256]	5	hSpCas9	negative selection	771756
46066910	46066933	1	-	26627737	DLD1	viability	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	1.1609246330293557	[606]	[329,515,429]	9	hSpCas9	negative selection	771757
46077575	46077598	1	-	26627737	DLD1	viability	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	0.8803226040273264	[105]	[34,57,85]	8	hSpCas9	negative selection	771758
46131908	46131931	1	-	26627737	DLD1	viability	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	0.7107034931742006	[671]	[313,358,356]	7	hSpCas9	negative selection	771759
46055805	46055828	1	+	26627737	GBM cells	viability after 5 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	0.28718446460174407	[135]	[87,89]	4	hSpCas9	negative selection	854070
46061949	46061972	1	-	26627737	GBM cells	viability after 5 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	-0.02618131610042368	[318]	[129,205]	0	hSpCas9	negative selection	854071
46066910	46066933	1	-	26627737	GBM cells	viability after 5 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	0.24627600032515096	[550]	[345,354]	4	hSpCas9	negative selection	854072
46077575	46077598	1	-	26627737	GBM cells	viability after 5 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	0.6111115639029496	[46]	[45,30]	8	hSpCas9	negative selection	854073
46131908	46131931	1	-	26627737	GBM cells	viability after 5 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	0.6455573829542458	[415]	[304,392]	8	hSpCas9	negative selection	854074
46055805	46055828	1	+	26627737	GBM cells	viability after 13 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	0.37584086425306534	[135]	[151,49]	5	hSpCas9	negative selection	936385
46061949	46061972	1	-	26627737	GBM cells	viability after 13 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	0.2908084715528697	[318]	[235,191]	4	hSpCas9	negative selection	936386
46066910	46066933	1	-	26627737	GBM cells	viability after 13 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	0.13400532939758802	[550]	[380,284]	1	hSpCas9	negative selection	936387
46077575	46077598	1	-	26627737	GBM cells	viability after 13 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	0.9745493723430425	[46]	[64,37]	9	hSpCas9	negative selection	936388
46131908	46131931	1	-	26627737	GBM cells	viability after 13 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	0.4679153781443879	[415]	[336,291]	6	hSpCas9	negative selection	936389
46055805	46055828	1	+	26627737	GBM cells	viability after 21 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	-0.18510836422369825	[135]	[76,53]	-2	hSpCas9	negative selection	1018700
46061949	46061972	1	-	26627737	GBM cells	viability after 21 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	0.676273473694035	[318]	[289,264]	6	hSpCas9	negative selection	1018701
46066910	46066933	1	-	26627737	GBM cells	viability after 21 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	0.2775763396306927	[550]	[377,348]	3	hSpCas9	negative selection	1018702
46077575	46077598	1	-	26627737	GBM cells	viability after 21 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	-0.0006735070137300347	[46]	[24,25]	0	hSpCas9	negative selection	1018703
46131908	46131931	1	-	26627737	GBM cells	viability after 21 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	0.6019050814236702	[415]	[377,310]	6	hSpCas9	negative selection	1018704
46055805	46055828	1	+	26627737	RPE1	viability after 9 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	1.2701260204888232	[222]	[170,164]	7	hSpCas9	negative selection	1101015
46061949	46061972	1	-	26627737	RPE1	viability after 9 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	0.9658815908212015	[1081]	[672,646]	6	hSpCas9	negative selection	1101016
46066910	46066933	1	-	26627737	RPE1	viability after 9 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	0.5991751069201129	[1322]	[657,587]	4	hSpCas9	negative selection	1101017
46077575	46077598	1	-	26627737	RPE1	viability after 9 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	0.9331468678159411	[200]	[103,140]	6	hSpCas9	negative selection	1101018
46131908	46131931	1	-	26627737	RPE1	viability after 9 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	0.3553738594282678	[1772]	[641,797]	2	hSpCas9	negative selection	1101019
46055805	46055828	1	+	26627737	RPE1	viability after 12 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	1.233885579210706	[222]	[120,161]	7	hSpCas9	negative selection	1183330
46061949	46061972	1	-	26627737	RPE1	viability after 12 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	0.9879821648950757	[1081]	[663,483]	6	hSpCas9	negative selection	1183331
46066910	46066933	1	-	26627737	RPE1	viability after 12 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	0.5224023273246939	[1322]	[528,490]	3	hSpCas9	negative selection	1183332
46077575	46077598	1	-	26627737	RPE1	viability after 12 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	1.1720757180995802	[200]	[144,96]	7	hSpCas9	negative selection	1183333
46131908	46131931	1	-	26627737	RPE1	viability after 12 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	0.7270753971808643	[1772]	[838,734]	5	hSpCas9	negative selection	1183334
46055805	46055828	1	+	26627737	RPE1	viability after 15 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	1.198978641125501	[222]	[182,107]	7	hSpCas9	negative selection	1265645
46061949	46061972	1	-	26627737	RPE1	viability after 15 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	1.167005149255296	[1081]	[699,674]	6	hSpCas9	negative selection	1265646
46066910	46066933	1	-	26627737	RPE1	viability after 15 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	0.6200691233130969	[1322]	[563,585]	4	hSpCas9	negative selection	1265647
46077575	46077598	1	-	26627737	RPE1	viability after 15 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	1.8583697442480334	[200]	[252,160]	8	hSpCas9	negative selection	1265648
46131908	46131931	1	-	26627737	RPE1	viability after 15 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	1.1251810099611166	[1772]	[1430,768]	6	hSpCas9	negative selection	1265649
46055805	46055828	1	+	26627737	RPE1	viability after 18 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	1.6675926349735766	[222]	[181,200]	8	hSpCas9	negative selection	1347960
46061949	46061972	1	-	26627737	RPE1	viability after 18 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	0.7021255109927855	[1081]	[563,379]	4	hSpCas9	negative selection	1347961
46066910	46066933	1	-	26627737	RPE1	viability after 18 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	0.7768217976509649	[1322]	[632,588]	5	hSpCas9	negative selection	1347962
46077575	46077598	1	-	26627737	RPE1	viability after 18 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	2.1825756584941716	[200]	[369,113]	9	hSpCas9	negative selection	1347963
46131908	46131931	1	-	26627737	RPE1	viability after 18 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	0.3012887920842955	[1772]	[679,492]	2	hSpCas9	negative selection	1347964
46055805	46055828	1	+	26627737	HeLa	viability after 8 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	0.3525971942726256	[140]	[52,135,42]	3	hSpCas9	negative selection	1430275
46061949	46061972	1	-	26627737	HeLa	viability after 8 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	0.2966754655709628	[629]	[349,250,406]	3	hSpCas9	negative selection	1430276
46066910	46066933	1	-	26627737	HeLa	viability after 8 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	0.38535241583605817	[712]	[803,249,259]	3	hSpCas9	negative selection	1430277
46077575	46077598	1	-	26627737	HeLa	viability after 8 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	-0.785267117108329	[96]	[19,5,44]	-7	hSpCas9	negative selection	1430278
46131908	46131931	1	-	26627737	HeLa	viability after 8 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	0.6725425889697085	[706]	[654,446,410]	6	hSpCas9	negative selection	1430279
46055805	46055828	1	+	26627737	HeLa	viability after 12 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	0.8250250893503238	[140]	[69,43,200]	6	hSpCas9	negative selection	1512590
46061949	46061972	1	-	26627737	HeLa	viability after 12 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	0.3513312691051623	[629]	[219,314,459]	3	hSpCas9	negative selection	1512591
46066910	46066933	1	-	26627737	HeLa	viability after 12 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	0.4366483317615959	[712]	[353,465,367]	4	hSpCas9	negative selection	1512592
46077575	46077598	1	-	26627737	HeLa	viability after 12 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	-0.1183778878118722	[96]	[31,42,34]	-1	hSpCas9	negative selection	1512593
46131908	46131931	1	-	26627737	HeLa	viability after 12 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	0.573922499080423	[706]	[364,441,494]	5	hSpCas9	negative selection	1512594
46055805	46055828	1	+	26627737	HeLa	viability after 15 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	1.1379018371865899	[140]	[78,168,131]	7	hSpCas9	negative selection	1594905
46061949	46061972	1	-	26627737	HeLa	viability after 15 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	0.3590999715392992	[629]	[301,346,338]	3	hSpCas9	negative selection	1594906
46066910	46066933	1	-	26627737	HeLa	viability after 15 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	0.30791324732373404	[712]	[365,326,386]	2	hSpCas9	negative selection	1594907
46077575	46077598	1	-	26627737	HeLa	viability after 15 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	-1.3789697334959947	[96]	[1,0,44]	-8	hSpCas9	negative selection	1594908
46131908	46131931	1	-	26627737	HeLa	viability after 15 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	0.41174198291809616	[706]	[344,410,393]	3	hSpCas9	negative selection	1594909
46055805	46055828	1	+	26627737	HeLa	viability after 18 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	1.12163133572686	[140]	[50,138,131]	7	hSpCas9	negative selection	1677220
46061949	46061972	1	-	26627737	HeLa	viability after 18 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	0.38304250607857904	[629]	[207,293,338]	3	hSpCas9	negative selection	1677221
46066910	46066933	1	-	26627737	HeLa	viability after 18 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	0.324769794991596	[712]	[251,272,386]	2	hSpCas9	negative selection	1677222
46077575	46077598	1	-	26627737	HeLa	viability after 18 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	-1.3406176293690506	[96]	[1,0,44]	-8	hSpCas9	negative selection	1677223
46131908	46131931	1	-	26627737	HeLa	viability after 18 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	0.430718961797798	[706]	[231,351,393]	3	hSpCas9	negative selection	1677224
46055805	46055828	1	+	26627737	HCT116	viability after 6 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	-1.9119812679366575	[166]	[15,1]	-8	hSpCas9	negative selection	1759535
46061949	46061972	1	-	26627737	HCT116	viability after 6 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	0.598060671964568	[1071]	[82,349]	3	hSpCas9	negative selection	1759536
46066910	46066933	1	-	26627737	HCT116	viability after 6 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	-0.04118865361465007	[1201]	[182,183]	0	hSpCas9	negative selection	1759537
46077575	46077598	1	-	26627737	HCT116	viability after 6 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	0.4957567167370529	[43]	[21,2]	2	hSpCas9	negative selection	1759538
46131908	46131931	1	-	26627737	HCT116	viability after 6 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	0.9325333141885337	[1355]	[810,183]	5	hSpCas9	negative selection	1759539
46055805	46055828	1	+	26627737	HCT116	viability after 8 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	-0.7779518399395776	[158]	[68,65,18]	-7	hSpCas9	negative selection	1841850
46061949	46061972	1	-	26627737	HCT116	viability after 8 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	0.7906511673928723	[289]	[278,246,302]	7	hSpCas9	negative selection	1841851
46066910	46066933	1	-	26627737	HCT116	viability after 8 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	0.9279977834124793	[330]	[269,365,402]	8	hSpCas9	negative selection	1841852
46077575	46077598	1	-	26627737	HCT116	viability after 8 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	0.18485230073265368	[39]	[6,55,11]	2	hSpCas9	negative selection	1841853
46131908	46131931	1	-	26627737	HCT116	viability after 8 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	-0.35958055814552203	[849]	[320,296,474]	-4	hSpCas9	negative selection	1841854
46055805	46055828	1	+	26627737	HCT116	viability after 9 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	1.428717565063211	[166]	[28,191]	8	hSpCas9	negative selection	1924165
46061949	46061972	1	-	26627737	HCT116	viability after 9 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	-0.3718447981841384	[1071]	[161,267]	-3	hSpCas9	negative selection	1924166
46066910	46066933	1	-	26627737	HCT116	viability after 9 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	0.0530689340242837	[1201]	[356,313]	0	hSpCas9	negative selection	1924167
46077575	46077598	1	-	26627737	HCT116	viability after 9 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	-0.21186656155370498	[43]	[3,14]	-1	hSpCas9	negative selection	1924168
46131908	46131931	1	-	26627737	HCT116	viability after 9 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	0.2208859372555958	[1355]	[507,353]	1	hSpCas9	negative selection	1924169
46055805	46055828	1	+	26627737	HCT116	viability after 12 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	0.31839744335020714	[158]	[90,114,107]	3	hSpCas9	negative selection	2006480
46061949	46061972	1	-	26627737	HCT116	viability after 12 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	1.2323492195863304	[289]	[312,309,453]	8	hSpCas9	negative selection	2006481
46066910	46066933	1	-	26627737	HCT116	viability after 12 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	0.8408945134891825	[330]	[295,431,210]	7	hSpCas9	negative selection	2006482
46077575	46077598	1	-	26627737	HCT116	viability after 12 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	0.89197936911274	[39]	[90,19,0]	7	hSpCas9	negative selection	2006483
46131908	46131931	1	-	26627737	HCT116	viability after 12 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	-0.37019808827674416	[849]	[364,382,287]	-4	hSpCas9	negative selection	2006484
46055805	46055828	1	+	26627737	HCT116	viability after 15 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	0.16168149254424813	[158]	[81,121,99]	1	hSpCas9	negative selection	2088795
46061949	46061972	1	-	26627737	HCT116	viability after 15 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	1.0484039707202122	[289]	[395,245,396]	8	hSpCas9	negative selection	2088796
46066910	46066933	1	-	26627737	HCT116	viability after 15 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	0.8855309272490928	[330]	[374,375,305]	7	hSpCas9	negative selection	2088797
46077575	46077598	1	-	26627737	HCT116	viability after 15 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	-0.2971227001431571	[39]	[17,18,18]	-3	hSpCas9	negative selection	2088798
46131908	46131931	1	-	26627737	HCT116	viability after 15 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	0.17041911964110912	[849]	[771,422,480]	1	hSpCas9	negative selection	2088799
46055805	46055828	1	+	26627737	HCT116	viability after 18 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	0.07129352295463987	[158]	[33,110,95]	0	hSpCas9	negative selection	2171110
46061949	46061972	1	-	26627737	HCT116	viability after 18 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	1.7222727423688637	[289]	[618,293,486]	9	hSpCas9	negative selection	2171111
46066910	46066933	1	-	26627737	HCT116	viability after 18 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	0.9017804309191413	[330]	[309,293,292]	7	hSpCas9	negative selection	2171112
46077575	46077598	1	-	26627737	HCT116	viability after 18 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	0.13536378263220428	[39]	[38,2,22]	1	hSpCas9	negative selection	2171113
46131908	46131931	1	-	26627737	HCT116	viability after 18 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	0.37119693914283913	[849]	[644,480,468]	3	hSpCas9	negative selection	2171114
46097843	46097866	1	+	25494202	A375	resistance to PLX-4720 (puromycin)	CACACCATTGCACTCCAGCCAGG	PIK3R3	ENSG00000278139	1.262249387691805	[54,80]	[6,66]	5	dCas9-VP64	positive selection	2396400
46133117	46133140	1	+	25494202	A375	resistance to PLX-4720 (puromycin)	AATCAGGAGACAGCCGGCGCCGG	PIK3R3	ENSG00000278139	1.7463409111697876	[7,116]	[55,36]	6	dCas9-VP64	positive selection	2397065
46133136	46133159	1	-	25494202	A375	resistance to PLX-4720 (puromycin)	CCAATCGCCGCCTTACCGGCCGG	PIK3R3	ENSG00000278139	-0.09572143768601438	[183,79]	[27,25]	0	dCas9-VP64	positive selection	2397066
46133166	46133189	1	+	25494202	A375	resistance to PLX-4720 (puromycin)	CCAGTTACTAAGCGGGACAAAGG	PIK3R3	ENSG00000278139	0.27837931937991334	[12,9]	[0,3]	1	dCas9-VP64	positive selection	2397067
46140012	46140035	1	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGCGTCTCGCTCTGTCACCCAAG	PIK3R3	ENSG00000278139	0.12861904683499015	[29,16]	[6,3]	0	dCas9-VP64	positive selection	2397590
46149015	46149038	1	+	25494202	A375	resistance to PLX-4720 (puromycin)	ACAGGATGCAGTAAAGAAGCTGG	PIK3R3	ENSG00000278139	4.925679733304566	[16,9]	[174,7]	9	dCas9-VP64	positive selection	2397759
46062457	46062480	1	+	25494202	A375	resistance to PLX-4720 (puromycin)	CCCAGCTACTCAGGAGGCCGAGG	PIK3R3	ENSG00000278139	1.2848086487689858	[4,11]	[0,7]	5	dCas9-VP64	positive selection	2402930
46103999	46104022	1	+	25494202	A375	resistance to PLX-4720 (puromycin)	CACTGCAACCTCTGCTCCCCGGG	PIK3R3	ENSG00000278139	-1.8290271006759882	[291,377]	[12,27]	-8	dCas9-VP64	positive selection	2406483
46102176	46102199	1	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGGGTTTCACCGTGTTAGCCAGG	PIK3R3	ENSG00000278139	0.853016361217498	[78,47]	[31,16]	3	dCas9-VP64	positive selection	2418378
46132874	46132897	1	-	25494202	A375	resistance to PLX-4720 (puromycin)	AGAGCGCGGATGGCTGATTGGGG	PIK3R3	ENSG00000278139	1.6820462801794651	[9,32]	[12,16]	6	dCas9-VP64	positive selection	2433233
46132850	46132873	1	-	25494202	A375	resistance to PLX-4720 (puromycin)	GCCGAAGCCTAGAGAGCGGTGGG	PIK3R3	ENSG00000278139	0.03716499533773018	[11,130]	[23,7]	0	dCas9-VP64	positive selection	2433234
46132829	46132852	1	-	25494202	A375	resistance to PLX-4720 (puromycin)	GGGAGACGTGAAAGTCGAGATGG	PIK3R3	ENSG00000278139	-1.1190630175380654	[21,65]	[4,2]	-6	dCas9-VP64	positive selection	2433235
46174952	46174975	1	-	25494202	A375	resistance to PLX-4720 (puromycin)	GCCGGAGAGGACATCAGCCCTGG	PIK3R3	ENSG00000278139	0.5233025514787601	[15,22]	[4,6]	2	dCas9-VP64	positive selection	2438508
46174907	46174930	1	-	25494202	A375	resistance to PLX-4720 (puromycin)	GGGGATGGGGAACAGCCTAAAGG	PIK3R3	ENSG00000278139	2.112582090016936	[2,49]	[1,50]	7	dCas9-VP64	positive selection	2438509
46174934	46174957	1	+	25494202	A375	resistance to PLX-4720 (puromycin)	TGACCTTCACTTTTCTTACCAGG	PIK3R3	ENSG00000278139	-1.9566302299324074	[447,104]	[9,20]	-9	dCas9-VP64	positive selection	2438510
46140516	46140539	1	+	25494202	A375	resistance to PLX-4720 (puromycin)	ATCTTGAGATAAGATCATCCTGG	PIK3R3	ENSG00000278139	2.1451580529990832	[53,113]	[62,103]	7	dCas9-VP64	positive selection	2445861
46079859	46079882	1	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGAGAATCGCTTGAACCCAAG	PIK3R3	ENSG00000278139	-1.1949452889942442	[147,110]	[6,17]	-7	dCas9-VP64	positive selection	2450016
46097843	46097866	1	+	25494202	A375	resistance to PLX-4720 (zeocin)	CACACCATTGCACTCCAGCCAGG	PIK3R3	ENSG00000278139	1.3472067688576927	[201,316]	[301,132]	7	dCas9-VP64	positive selection	2491655
46133117	46133140	1	+	25494202	A375	resistance to PLX-4720 (zeocin)	AATCAGGAGACAGCCGGCGCCGG	PIK3R3	ENSG00000278139	1.3656444258760345	[33,44]	[14,49]	7	dCas9-VP64	positive selection	2492320
46133136	46133159	1	-	25494202	A375	resistance to PLX-4720 (zeocin)	CCAATCGCCGCCTTACCGGCCGG	PIK3R3	ENSG00000278139	-0.10401952426350614	[77,295]	[42,67]	-1	dCas9-VP64	positive selection	2492321
46133166	46133189	1	+	25494202	A375	resistance to PLX-4720 (zeocin)	CCAGTTACTAAGCGGGACAAAGG	PIK3R3	ENSG00000278139	-0.017909599282020183	[17,59]	[9,13]	0	dCas9-VP64	positive selection	2492322
46140012	46140035	1	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGCGTCTCGCTCTGTCACCCAAG	PIK3R3	ENSG00000278139	0.14591061539525366	[144,47]	[52,17]	1	dCas9-VP64	positive selection	2492845
46149015	46149038	1	+	25494202	A375	resistance to PLX-4720 (zeocin)	ACAGGATGCAGTAAAGAAGCTGG	PIK3R3	ENSG00000278139	0.38906795686834106	[19,135]	[18,44]	3	dCas9-VP64	positive selection	2493014
46062457	46062480	1	+	25494202	A375	resistance to PLX-4720 (zeocin)	CCCAGCTACTCAGGAGGCCGAGG	PIK3R3	ENSG00000278139	-0.42778639369274607	[66,93]	[18,18]	-4	dCas9-VP64	positive selection	2498185
46103999	46104022	1	+	25494202	A375	resistance to PLX-4720 (zeocin)	CACTGCAACCTCTGCTCCCCGGG	PIK3R3	ENSG00000278139	0.4396579999349357	[510,531]	[180,277]	3	dCas9-VP64	positive selection	2501738
46102176	46102199	1	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGGGTTTCACCGTGTTAGCCAGG	PIK3R3	ENSG00000278139	1.9224239682243596	[76,41]	[141,10]	8	dCas9-VP64	positive selection	2513633
46132874	46132897	1	-	25494202	A375	resistance to PLX-4720 (zeocin)	AGAGCGCGGATGGCTGATTGGGG	PIK3R3	ENSG00000278139	-1.0621669068976738	[95,77]	[21,4]	-8	dCas9-VP64	positive selection	2528488
46132850	46132873	1	-	25494202	A375	resistance to PLX-4720 (zeocin)	GCCGAAGCCTAGAGAGCGGTGGG	PIK3R3	ENSG00000278139	0.5451649750713664	[32,63]	[7,35]	4	dCas9-VP64	positive selection	2528489
46132829	46132852	1	-	25494202	A375	resistance to PLX-4720 (zeocin)	GGGAGACGTGAAAGTCGAGATGG	PIK3R3	ENSG00000278139	0.5039852579197976	[31,78]	[11,37]	4	dCas9-VP64	positive selection	2528490
46174952	46174975	1	-	25494202	A375	resistance to PLX-4720 (zeocin)	GCCGGAGAGGACATCAGCCCTGG	PIK3R3	ENSG00000278139	-0.05241237226315931	[132,147]	[55,31]	0	dCas9-VP64	positive selection	2533763
46174907	46174930	1	-	25494202	A375	resistance to PLX-4720 (zeocin)	GGGGATGGGGAACAGCCTAAAGG	PIK3R3	ENSG00000278139	-0.25073428019052657	[36,76]	[13,15]	-2	dCas9-VP64	positive selection	2533764
46174934	46174957	1	+	25494202	A375	resistance to PLX-4720 (zeocin)	TGACCTTCACTTTTCTTACCAGG	PIK3R3	ENSG00000278139	1.9963187454698805	[96,184]	[31,323]	8	dCas9-VP64	positive selection	2533765
46140516	46140539	1	+	25494202	A375	resistance to PLX-4720 (zeocin)	ATCTTGAGATAAGATCATCCTGG	PIK3R3	ENSG00000278139	-0.6333367816877012	[107,293]	[31,50]	-6	dCas9-VP64	positive selection	2541116
46079859	46079882	1	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGAGAATCGCTTGAACCCAAG	PIK3R3	ENSG00000278139	1.2597172262171965	[381,372]	[459,141]	7	dCas9-VP64	positive selection	2545271
46077536	46077559	1	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GATGCCTCAACAAAAATGCAGGG	PIK3R3	ENSG00000278139	-0.03360387624088626	[4,4]	[3,2]	0	hSpCas9	positive selection	3011395
46080652	46080675	1	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGATGCAGAATGGTACTGGGGGG	PIK3R3	ENSG00000278139	-0.4175147313315036	[3,3]	[2,0]	-5	hSpCas9	positive selection	3011396
46066990	46067013	1	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	0.06379851772663711	[2,3]	[2,3]	1	hSpCas9	positive selection	3011397
46131940	46131963	1	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TGACAGCGCGATGTACAATACGG	PIK3R3	ENSG00000278139	-0.07159192379474308	[2,3]	[3,1]	-1	hSpCas9	positive selection	3011398
46077536	46077559	1	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GATGCCTCAACAAAAATGCAGGG	PIK3R3	ENSG00000278139	0.041913814302073193	[4,4]	[3,2]	0	hSpCas9	positive selection	3079253
46080652	46080675	1	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGATGCAGAATGGTACTGGGGGG	PIK3R3	ENSG00000278139	0.45990219406615196	[3,3]	[3,3]	7	hSpCas9	positive selection	3079254
46066990	46067013	1	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	0.0315936534060029	[2,2]	[2,1]	0	hSpCas9	positive selection	3079255
46131940	46131963	1	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TGACAGCGCGATGTACAATACGG	PIK3R3	ENSG00000278139	-0.08054114557863928	[2,2]	[2,1]	-1	hSpCas9	positive selection	3079256
46080711	46080734		+	24336571	A375	resistance to PLX after 7 days	ACTGCTGAAGTCATTGGCTTAGG	PIK3R3	ENSG00000278139	-0.11246886395841771	[10,8]	[8,8]	-3	hSpCas9	positive selection	3135658
46080702	46080725		-	24336571	A375	resistance to PLX after 7 days	ATGACTTCAGCAGTTCCAAATGG	PIK3R3	ENSG00000278139	-0.05238804325637414	[3,4]	[3,4]	-1	hSpCas9	positive selection	3135659
46080687	46080710		+	24336571	A375	resistance to PLX after 7 days	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	-0.0430397880863278	[31,24]	[28,25]	-1	hSpCas9	positive selection	3135660
46061951	46061974		-	24336571	A375	resistance to PLX after 7 days	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.3107332566336003	[5,5]	[5,8]	8	hSpCas9	positive selection	3135661
46080711	46080734		+	24336571	A375	resistance to PLX after 14 days	ACTGCTGAAGTCATTGGCTTAGG	PIK3R3	ENSG00000278139	-0.6380607360584627	[13,7]	[1,2]	-7	hSpCas9	positive selection	3193451
46080702	46080725		-	24336571	A375	resistance to PLX after 14 days	ATGACTTCAGCAGTTCCAAATGG	PIK3R3	ENSG00000278139	0.4288745452118341	[1,5]	[1,1]	4	hSpCas9	positive selection	3193452
46080687	46080710		+	24336571	A375	resistance to PLX after 14 days	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.25804392490867567	[39,26]	[16,19]	2	hSpCas9	positive selection	3193453
46061951	46061974		-	24336571	A375	resistance to PLX after 14 days	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	-0.3876974257494279	[9,12]	[3,2]	-4	hSpCas9	positive selection	3193454
46080711	46080734		+	24336571	A375	viability after 7 days	ACTGCTGAAGTCATTGGCTTAGG	PIK3R3	ENSG00000278139	0.3148775808636455	[7]	[10,8]	5	hSpCas9	negative selection	3251244
46080702	46080725		-	24336571	A375	viability after 7 days	ATGACTTCAGCAGTTCCAAATGG	PIK3R3	ENSG00000278139	-0.44666053474489487	[6]	[3,4]	-6	hSpCas9	negative selection	3251245
46080687	46080710		+	24336571	A375	viability after 7 days	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.3473690449781115	[22]	[31,24]	5	hSpCas9	negative selection	3251246
46061951	46061974		-	24336571	A375	viability after 7 days	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	-0.10359182177131643	[6]	[5,5]	-1	hSpCas9	negative selection	3251247
46080711	46080734		+	24336571	A375	viability after 14 days	ACTGCTGAAGTCATTGGCTTAGG	PIK3R3	ENSG00000278139	0.4334771353495136	[7]	[13,7]	5	hSpCas9	negative selection	3309037
46080702	46080725		-	24336571	A375	viability after 14 days	ATGACTTCAGCAGTTCCAAATGG	PIK3R3	ENSG00000278139	-0.6366713622041364	[6]	[1,5]	-6	hSpCas9	negative selection	3309038
46080687	46080710		+	24336571	A375	viability after 14 days	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.5802545116261744	[22]	[39,26]	7	hSpCas9	negative selection	3309039
46061951	46061974		-	24336571	A375	viability after 14 days	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.7732168620590949	[6]	[9,12]	8	hSpCas9	negative selection	3309040
46080687	46080710	1	+	27383988	293T	resistance to West Nile virus (flavivirus)	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	-0.8354309294740174	[272,272]	[0,0]	-5	hSpCas9	positive selection	3385899
46046570	46046593	1	+	27383988	293T	resistance to West Nile virus (flavivirus)	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	-1.36838263161863	[394,394]	[0,0]	-8	hSpCas9	positive selection	3385900
46062054	46062077	1	-	27383988	293T	resistance to West Nile virus (flavivirus)	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	1.4759664979211755	[54,54]	[0,0]	6	hSpCas9	positive selection	3385901
46077536	46077559	1	-	26780180	HT29	viability (Avana library 4 designs)	GATGCCTCAACAAAAATGCAGGG	PIK3R3	ENSG00000278139	0.177022757780393	[]	[]	0	hSpCas9	negative selection	3449478
46080652	46080675	1	-	26780180	HT29	viability (Avana library 4 designs)	GGATGCAGAATGGTACTGGGGGG	PIK3R3	ENSG00000278139	1.49422093142826	[]	[]	6	hSpCas9	negative selection	3449479
46066989	46067012	1	+	26780180	HT29	viability (Avana library 4 designs)	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	0.438357279862848	[]	[]	1	hSpCas9	negative selection	3449480
46131940	46131963	1	-	26780180	HT29	viability (Avana library 4 designs)	TGACAGCGCGATGTACAATACGG	PIK3R3	ENSG00000278139	0.895601230179629	[]	[]	3	hSpCas9	negative selection	3449481
46077536	46077559	1	-	26780180	A375	viability (Avana lentiCRISPRv2)	GATGCCTCAACAAAAATGCAGGG	PIK3R3	ENSG00000278139	-1.62440065842663	[]	[]	-2	hSpCas9	negative selection	3544261
46080652	46080675	1	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGATGCAGAATGGTACTGGGGGG	PIK3R3	ENSG00000278139	2.43390992158429	[]	[]	3	hSpCas9	negative selection	3544262
46131940	46131963	1	-	26780180	A375	viability (Avana lentiCRISPRv2)	TGACAGCGCGATGTACAATACGG	PIK3R3	ENSG00000278139	0.0717294684430927	[]	[]	0	hSpCas9	negative selection	3544263
46066989	46067012	1	+	26780180	A375	viability (Avana lentiCRISPRv2)	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	1.74122954271595	[]	[]	2	hSpCas9	negative selection	3544264
46080702	46080725	1	-	26780180	A375	viability (Avana lentiCRISPRv2)	ATGACTTCAGCAGTTCCAAATGG	PIK3R3	ENSG00000278139	-3.63740337697011	[]	[]	-4	hSpCas9	negative selection	3544265
46066895	46066918	1	+	26780180	A375	viability (Avana lentiCRISPRv2)	ATTTCCATAATCATACCTGTTGG	PIK3R3	ENSG00000278139	-10.0517912014951	[]	[]	-7	hSpCas9	negative selection	3544266
46077536	46077559	1	-	26780180	A375	viability (Avana lentiGuide)	GATGCCTCAACAAAAATGCAGGG	PIK3R3	ENSG00000278139	-3.90843130708335	[]	[]	-6	hSpCas9	negative selection	3652920
46080652	46080675	1	-	26780180	A375	viability (Avana lentiGuide)	GGATGCAGAATGGTACTGGGGGG	PIK3R3	ENSG00000278139	2.15101028396557	[]	[]	2	hSpCas9	negative selection	3652921
46131940	46131963	1	-	26780180	A375	viability (Avana lentiGuide)	TGACAGCGCGATGTACAATACGG	PIK3R3	ENSG00000278139	-0.877717777278542	[]	[]	-1	hSpCas9	negative selection	3652922
46066989	46067012	1	+	26780180	A375	viability (Avana lentiGuide)	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	0.337934897388655	[]	[]	0	hSpCas9	negative selection	3652923
46080702	46080725	1	-	26780180	A375	viability (Avana lentiGuide)	ATGACTTCAGCAGTTCCAAATGG	PIK3R3	ENSG00000278139	-3.49730269260804	[]	[]	-6	hSpCas9	negative selection	3652924
46066895	46066918	1	+	26780180	A375	viability (Avana lentiGuide)	ATTTCCATAATCATACCTGTTGG	PIK3R3	ENSG00000278139	-2.24843559628775	[]	[]	-4	hSpCas9	negative selection	3652925
46077536	46077559	1	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GATGCCTCAACAAAAATGCAGGG	PIK3R3	ENSG00000278139	-0.0887052291804161	[5]	[4,4]	-1	hSpCas9	positive selection	3761579
46080652	46080675	1	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGATGCAGAATGGTACTGGGGGG	PIK3R3	ENSG00000278139	0.14000481567993467	[4]	[5,4]	4	hSpCas9	positive selection	3761580
46131940	46131963	1	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGACAGCGCGATGTACAATACGG	PIK3R3	ENSG00000278139	-0.1330424783367321	[4]	[3,4]	-2	hSpCas9	positive selection	3761581
46066989	46067012	1	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	0.2190150822442349	[5]	[6,5]	6	hSpCas9	positive selection	3761582
46080702	46080725	1	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ATGACTTCAGCAGTTCCAAATGG	PIK3R3	ENSG00000278139	-0.16002246803830095	[5]	[4,4]	-3	hSpCas9	positive selection	3761583
46066895	46066918	1	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ATTTCCATAATCATACCTGTTGG	PIK3R3	ENSG00000278139	-0.5220453196111758	[9]	[6,5]	-6	hSpCas9	positive selection	3761584
46077536	46077559	1	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GATGCCTCAACAAAAATGCAGGG	PIK3R3	ENSG00000278139	0.29106565597211337	[5]	[6,5]	7	hSpCas9	positive selection	3870186
46080652	46080675	1	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGATGCAGAATGGTACTGGGGGG	PIK3R3	ENSG00000278139	-1.1676611718615237	[5]	[0,1]	-8	hSpCas9	positive selection	3870187
46131940	46131963	1	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGACAGCGCGATGTACAATACGG	PIK3R3	ENSG00000278139	0.1448259371726813	[4]	[5,3]	3	hSpCas9	positive selection	3870188
46066989	46067012	1	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	0.3757342004517791	[4]	[5,5]	9	hSpCas9	positive selection	3870189
46080702	46080725	1	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ATGACTTCAGCAGTTCCAAATGG	PIK3R3	ENSG00000278139	0.40846049455728806	[5]	[5,5]	9	hSpCas9	positive selection	3870190
46066895	46066918	1	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ATTTCCATAATCATACCTGTTGG	PIK3R3	ENSG00000278139	0.2651877098369057	[7]	[8,6]	7	hSpCas9	positive selection	3870191
46080687	46080710	1	+	26780180	A375	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.524710967552177	[]	[]	1	hSpCas9	negative selection	3980993
46046608	46046631	1	-	26780180	A375	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	0.84110036899869	[]	[]	3	hSpCas9	negative selection	3980994
46080641	46080664	1	-	26780180	A375	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	0.654388345722541	[]	[]	2	hSpCas9	negative selection	3980995
46046570	46046593	1	+	26780180	A375	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.938530113669803	[]	[]	4	hSpCas9	negative selection	3980996
46061951	46061974	1	-	26780180	A375	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.70368883342877	[]	[]	2	hSpCas9	negative selection	3980997
46062054	46062077	1	-	26780180	A375	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	1.01278031225675	[]	[]	5	hSpCas9	negative selection	3980998
46080687	46080710	1	+	26780180	HT29	viability (GeCKOv2 library)	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	1.00786363733216	[]	[]	4	hSpCas9	negative selection	4088959
46046608	46046631	1	-	26780180	HT29	viability (GeCKOv2 library)	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	0.709935873431431	[]	[]	2	hSpCas9	negative selection	4088960
46080641	46080664	1	-	26780180	HT29	viability (GeCKOv2 library)	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	0.862603271923156	[]	[]	3	hSpCas9	negative selection	4088961
46046570	46046593	1	+	26780180	HT29	viability (GeCKOv2 library)	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	1.07807138419517	[]	[]	5	hSpCas9	negative selection	4088962
46061951	46061974	1	-	26780180	HT29	viability (GeCKOv2 library)	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.257412927707373	[]	[]	0	hSpCas9	negative selection	4088963
46062054	46062077	1	-	26780180	HT29	viability (GeCKOv2 library)	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	0.77174053056271	[]	[]	3	hSpCas9	negative selection	4088964
46080711	46080734	1	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	ACTGCTGAAGTCATTGGCTTAGG	PIK3R3	ENSG00000278139	-0.4641746852820747	[3]	[1,1]	-8	hSpCas9	positive selection	4160611
46080702	46080725	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	ATGACTTCAGCAGTTCCAAATGG	PIK3R3	ENSG00000278139	-0.2805750149010494	[2]	[0,0]	-6	hSpCas9	positive selection	4160612
46080687	46080710	1	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.2698492762656958	[4]	[2,4]	6	hSpCas9	positive selection	4160613
46061951	46061974	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.040058782927343745	[3]	[2,1]	1	hSpCas9	positive selection	4160614
46080711	46080734	1	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	ACTGCTGAAGTCATTGGCTTAGG	PIK3R3	ENSG00000278139	0.9837572590283978	[3]	[3,0,0,4]	7	hSpCas9	positive selection	4224633
46080702	46080725	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	ATGACTTCAGCAGTTCCAAATGG	PIK3R3	ENSG00000278139	0.06856194881909798	[3]	[2,1,2,0]	0	hSpCas9	positive selection	4224634
46080687	46080710	1	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	1.1041290719328563	[4]	[3,3,3,4]	8	hSpCas9	positive selection	4224635
46061951	46061974	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.8732624655060122	[0]	[0,0,0,0]	6	hSpCas9	positive selection	4224636
46061951	46061974	1	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	-0.01742534471767098	[3]	[2,1]	0	hSpCas9	positive selection	4290303
46046608	46046631	1	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	0.03670756125220059	[2]	[2,1]	0	hSpCas9	positive selection	4290304
46080641	46080664	1	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	0.21922317212901576	[0]	[1,0]	4	hSpCas9	positive selection	4290305
46080687	46080710	1	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.4242499668290722	[3]	[3,3]	8	hSpCas9	positive selection	4354555
46046570	46046593	1	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.039898144865378404	[4]	[3,2]	0	hSpCas9	positive selection	4354556
46062054	46062077	1	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	0.1790389951847535	[2]	[1,1]	3	hSpCas9	positive selection	4354557
46055806	46055828	1	+	27760321	OCIAML3	viability	ATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	0.25016038470945623	[997,873]	[909,814]	3	hSpCas9	negative selection	4427876
46061951	46061973	1	-	27760321	OCIAML3	viability	ATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	-0.18393753322957646	[422,340]	[218,316]	-2	hSpCas9	negative selection	4427877
46067003	46067025	1	-	27760321	OCIAML3	viability	CTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	0.4131156842125919	[540,442]	[475,553]	5	hSpCas9	negative selection	4427878
46067047	46067069	1	-	27760321	OCIAML3	viability	TAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	-0.24537846921569273	[390,293]	[194,261]	-3	hSpCas9	negative selection	4427879
46077574	46077596	1	-	27760321	OCIAML3	viability	ATTGCGGGATATGCCAGATGGG	PIK3R3	ENSG00000278139	0.18554764347190367	[541,412]	[390,460]	2	hSpCas9	negative selection	4427880
46055806	46055828	1	+	27760321	OCIAML2	viability	ATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	0.5993919234265883	[997,873]	[871,1503]	7	hSpCas9	negative selection	4511339
46061951	46061973	1	-	27760321	OCIAML2	viability	ATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.3768907342412045	[422,340]	[285,547]	5	hSpCas9	negative selection	4511340
46067003	46067025	1	-	27760321	OCIAML2	viability	CTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	-0.04046704688287328	[540,442]	[410,350]	0	hSpCas9	negative selection	4511341
46067047	46067069	1	-	27760321	OCIAML2	viability	TAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	-0.07581532399323748	[390,293]	[242,283]	-1	hSpCas9	negative selection	4511342
46077574	46077596	1	-	27760321	OCIAML2	viability	ATTGCGGGATATGCCAGATGGG	PIK3R3	ENSG00000278139	0.57671955802484	[541,412]	[480,690]	7	hSpCas9	negative selection	4511343
46055806	46055828	1	+	27760321	MV411	viability	ATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	0.268211817861445	[997,873]	[336,1350]	2	hSpCas9	negative selection	4594802
46061951	46061973	1	-	27760321	MV411	viability	ATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	-0.8897885515477417	[422,340]	[8,324]	-5	hSpCas9	negative selection	4594803
46067003	46067025	1	-	27760321	MV411	viability	CTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	0.5230901885504025	[540,442]	[319,680]	4	hSpCas9	negative selection	4594804
46067047	46067069	1	-	27760321	MV411	viability	TAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	-0.5737450873133082	[390,293]	[134,173]	-4	hSpCas9	negative selection	4594805
46077574	46077596	1	-	27760321	MV411	viability	ATTGCGGGATATGCCAGATGGG	PIK3R3	ENSG00000278139	-0.6371568409642063	[541,412]	[228,158]	-4	hSpCas9	negative selection	4594806
46055806	46055828	1	+	27760321	HL60	viability	ATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	-0.20229903772173008	[997,873]	[567,763]	-2	hSpCas9	negative selection	4678265
46061951	46061973	1	-	27760321	HL60	viability	ATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.2774288880961233	[422,340]	[346,406]	3	hSpCas9	negative selection	4678266
46067003	46067025	1	-	27760321	HL60	viability	CTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	-0.05366371859274835	[540,442]	[412,355]	0	hSpCas9	negative selection	4678267
46067047	46067069	1	-	27760321	HL60	viability	TAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.21915286079531623	[390,293]	[271,376]	2	hSpCas9	negative selection	4678268
46077574	46077596	1	-	27760321	HL60	viability	ATTGCGGGATATGCCAGATGGG	PIK3R3	ENSG00000278139	0.40024884311032355	[541,412]	[336,694]	5	hSpCas9	negative selection	4678269
46055806	46055828	1	+	27760321	HT1080	viability	ATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	0.8780547877766292	[873,681]	[687,439]	5	hSpCas9	negative selection	4761728
46061951	46061973	1	-	27760321	HT1080	viability	ATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	1.1803611128890255	[340,265]	[252,296]	6	hSpCas9	negative selection	4761729
46067003	46067025	1	-	27760321	HT1080	viability	CTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	0.5284017424949696	[442,345]	[82,383]	2	hSpCas9	negative selection	4761730
46067047	46067069	1	-	27760321	HT1080	viability	TAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	-0.6110545197236621	[293,229]	[43,94]	-3	hSpCas9	negative selection	4761731
46077574	46077596	1	-	27760321	HT1080	viability	ATTGCGGGATATGCCAGATGGG	PIK3R3	ENSG00000278139	1.7230514195239688	[412,321]	[520,441]	8	hSpCas9	negative selection	4761732
46055806	46055828	1	+	27760321	HT29	viability after 7 days	ATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	0.028279559617408356	[873,681]	[945,1139,963]	0	hSpCas9	negative selection	4845191
46061951	46061973	1	-	27760321	HT29	viability after 7 days	ATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.04218451700381051	[340,265]	[466,279,464]	0	hSpCas9	negative selection	4845192
46067003	46067025	1	-	27760321	HT29	viability after 7 days	CTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	-0.14894779018623866	[442,345]	[587,268,530]	-2	hSpCas9	negative selection	4845193
46067047	46067069	1	-	27760321	HT29	viability after 7 days	TAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.3870137669972475	[293,229]	[461,544,320]	6	hSpCas9	negative selection	4845194
46077574	46077596	1	-	27760321	HT29	viability after 7 days	ATTGCGGGATATGCCAGATGGG	PIK3R3	ENSG00000278139	0.5548552707282332	[412,321]	[612,646,805]	8	hSpCas9	negative selection	4845195
46055806	46055828	1	+	27760321	HT29	viability after 25 days	ATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	0.1600629118234671	[873,681]	[899,1165,909]	1	hSpCas9	negative selection	4928654
46061951	46061973	1	-	27760321	HT29	viability after 25 days	ATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.19158308694439413	[340,265]	[324,368,509]	2	hSpCas9	negative selection	4928655
46067003	46067025	1	-	27760321	HT29	viability after 25 days	CTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	-0.3044747541227496	[442,345]	[215,359,546]	-3	hSpCas9	negative selection	4928656
46067047	46067069	1	-	27760321	HT29	viability after 25 days	TAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.37045772396325777	[293,229]	[364,342,461]	4	hSpCas9	negative selection	4928657
46077574	46077596	1	-	27760321	HT29	viability after 25 days	ATTGCGGGATATGCCAGATGGG	PIK3R3	ENSG00000278139	0.5409649641976729	[412,321]	[452,752,638]	6	hSpCas9	negative selection	4928658
46055806	46055828	1	+	27760321	HT29	viability after 22 days	ATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	0.19723152752287088	[873,681]	[961,1236,894]	2	hSpCas9	negative selection	5012117
46061951	46061973	1	-	27760321	HT29	viability after 22 days	ATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	-0.22852750044105033	[340,265]	[401,253,238]	-2	hSpCas9	negative selection	5012118
46067003	46067025	1	-	27760321	HT29	viability after 22 days	CTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	-0.03476044295788727	[442,345]	[406,451,477]	0	hSpCas9	negative selection	5012119
46067047	46067069	1	-	27760321	HT29	viability after 22 days	TAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.2364576406368488	[293,229]	[408,325,333]	2	hSpCas9	negative selection	5012120
46077574	46077596	1	-	27760321	HT29	viability after 22 days	ATTGCGGGATATGCCAGATGGG	PIK3R3	ENSG00000278139	0.33678908469668106	[412,321]	[614,500,490]	3	hSpCas9	negative selection	5012121
46055806	46055828	1	+	27760321	HT29	viability after 19 days	ATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	-0.11284241600089917	[873,681]	[1292,477,748]	-1	hSpCas9	negative selection	5095580
46061951	46061973	1	-	27760321	HT29	viability after 19 days	ATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	-0.2987077864511718	[340,265]	[510,68,289]	-3	hSpCas9	negative selection	5095581
46067003	46067025	1	-	27760321	HT29	viability after 19 days	CTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	-0.08422683563206787	[442,345]	[363,584,324]	-1	hSpCas9	negative selection	5095582
46067047	46067069	1	-	27760321	HT29	viability after 19 days	TAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.6935903334038398	[293,229]	[585,223,647]	7	hSpCas9	negative selection	5095583
46077574	46077596	1	-	27760321	HT29	viability after 19 days	ATTGCGGGATATGCCAGATGGG	PIK3R3	ENSG00000278139	1.1361825067432691	[412,321]	[798,777,1170]	9	hSpCas9	negative selection	5095584
46055806	46055828	1	+	27760321	HT29	viability after 16 days	ATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	0.31868117518533867	[873,681]	[1327,796,1161]	3	hSpCas9	negative selection	5179043
46061951	46061973	1	-	27760321	HT29	viability after 16 days	ATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.20046680162534114	[340,265]	[463,213,503]	2	hSpCas9	negative selection	5179044
46067003	46067025	1	-	27760321	HT29	viability after 16 days	CTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	0.3147084060454548	[442,345]	[358,353,920]	3	hSpCas9	negative selection	5179045
46067047	46067069	1	-	27760321	HT29	viability after 16 days	TAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.03319165551935399	[293,229]	[329,290,281]	0	hSpCas9	negative selection	5179046
46077574	46077596	1	-	27760321	HT29	viability after 16 days	ATTGCGGGATATGCCAGATGGG	PIK3R3	ENSG00000278139	0.7203720223869928	[412,321]	[719,488,831]	8	hSpCas9	negative selection	5179047
46055806	46055828	1	+	27760321	HT29	viability after 13 days	ATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	0.10981376147052169	[873,681]	[1036,1089,804]	1	hSpCas9	negative selection	5262506
46061951	46061973	1	-	27760321	HT29	viability after 13 days	ATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	-0.022707198968518055	[340,265]	[282,361,391]	0	hSpCas9	negative selection	5262507
46067003	46067025	1	-	27760321	HT29	viability after 13 days	CTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	-0.21713491399522541	[442,345]	[356,443,380]	-3	hSpCas9	negative selection	5262508
46067047	46067069	1	-	27760321	HT29	viability after 13 days	TAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.34828669483501845	[293,229]	[326,411,419]	4	hSpCas9	negative selection	5262509
46077574	46077596	1	-	27760321	HT29	viability after 13 days	ATTGCGGGATATGCCAGATGGG	PIK3R3	ENSG00000278139	0.6210663339027436	[412,321]	[880,627,468]	7	hSpCas9	negative selection	5262510
46055806	46055828	1	+	27760321	HT29	viability after 10 days	ATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	-0.012724828078701789	[873,681]	[911,1138,844]	0	hSpCas9	negative selection	5345969
46061951	46061973	1	-	27760321	HT29	viability after 10 days	ATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	-0.04766130883562894	[340,265]	[299,400,398]	0	hSpCas9	negative selection	5345970
46067003	46067025	1	-	27760321	HT29	viability after 10 days	CTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	0.2644635822278777	[442,345]	[514,526,727]	3	hSpCas9	negative selection	5345971
46067047	46067069	1	-	27760321	HT29	viability after 10 days	TAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.11196659626485345	[293,229]	[410,454,200]	1	hSpCas9	negative selection	5345972
46077574	46077596	1	-	27760321	HT29	viability after 10 days	ATTGCGGGATATGCCAGATGGG	PIK3R3	ENSG00000278139	0.33008670021760567	[412,321]	[621,471,631]	4	hSpCas9	negative selection	5345973
46055806	46055828	1	+	27760321	MOLM13	viability	ATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	0.16256561958686744	[997,873]	[652,535]	1	hSpCas9	negative selection	5429432
46061951	46061973	1	-	27760321	MOLM13	viability	ATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.2886847673842081	[422,340]	[223,293]	2	hSpCas9	negative selection	5429433
46067003	46067025	1	-	27760321	MOLM13	viability	CTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	-0.15892383372127886	[540,442]	[335,171]	-1	hSpCas9	negative selection	5429434
46067047	46067069	1	-	27760321	MOLM13	viability	TAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.8244170322555003	[390,293]	[159,491]	6	hSpCas9	negative selection	5429435
46077574	46077596	1	-	27760321	MOLM13	viability	ATTGCGGGATATGCCAGATGGG	PIK3R3	ENSG00000278139	0.9321657254617058	[541,412]	[690,355]	6	hSpCas9	negative selection	5429436
46132447	46132470	1	+	27661255	K562	viability	GCAGAGAGCGAATCCCCCAGAGG	PIK3R3	ENSG00000278139	-0.042008883421188026	[432,526]	[389,354]	-2	dCas9-KRAB	negative selection	5501948
46132576	46132599	1	-	27661255	K562	viability	GGTTGGTTCTTACACCCCGGCGG	PIK3R3	ENSG00000278139	-0.023184640295382586	[1066,1079]	[915,781]	-1	dCas9-KRAB	negative selection	5501949
46132602	46132625	1	-	27661255	K562	viability	GAGCTTGAGGGCAGTTGGTGCGG	PIK3R3	ENSG00000278139	0.24811395502143496	[408,492]	[440,413]	8	dCas9-KRAB	negative selection	5501950
46132607	46132630	1	-	27661255	K562	viability	GGGCAGAGCTTGAGGGCAGTTGG	PIK3R3	ENSG00000278139	0.11290522096635802	[915,1098]	[928,814]	4	dCas9-KRAB	negative selection	5501951
46132614	46132637	1	-	27661255	K562	viability	GGAGTCCGGGCAGAGCTTGAGGG	PIK3R3	ENSG00000278139	0.1600635597276947	[1180,1377]	[1235,1055]	5	dCas9-KRAB	negative selection	5501952
46061951	46061974	1	-	27260156	BXPC3	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.0508042301995701	[476]	[454,442,649,529]	1	hSpCas9	negative selection	5562763
46046608	46046631	1	-	27260156	BXPC3	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	-0.2599662761347876	[252]	[198,222,189,278]	-5	hSpCas9	negative selection	5562764
46080641	46080664	1	-	27260156	BXPC3	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	0.5525653792687395	[59]	[59,53,98,169]	9	hSpCas9	negative selection	5562765
46080687	46080710	1	+	27260156	BXPC3	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.16679498513792473	[591]	[608,598,758,841]	3	hSpCas9	negative selection	5627015
46046570	46046593	1	+	27260156	BXPC3	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	-0.01587879787139701	[1078]	[927,1048,1242,1282]	0	hSpCas9	negative selection	5627016
46062054	46062077	1	-	27260156	BXPC3	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.27323419135782756	[217]	[128,140,178,330]	-6	hSpCas9	negative selection	5627017
46061951	46061974	1	-	27260156	A673	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.22932819331073778	[476]	[581,716,651,724]	5	hSpCas9	negative selection	5684014
46046608	46046631	1	-	27260156	A673	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	-0.16999786754465318	[252]	[407,214,196,277]	-4	hSpCas9	negative selection	5684015
46080641	46080664	1	-	27260156	A673	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	0.7306431437458429	[59]	[136,82,107,154]	9	hSpCas9	negative selection	5684016
46080687	46080710	1	+	27260156	A673	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.21991074763007956	[591]	[759,852,831,857]	5	hSpCas9	negative selection	5748266
46046570	46046593	1	+	27260156	A673	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.06502372875549467	[1078]	[1615,1357,1218,1250]	1	hSpCas9	negative selection	5748267
46062054	46062077	1	-	27260156	A673	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.011365302457497117	[217]	[265,220,259,294]	0	hSpCas9	negative selection	5748268
46061951	46061974	1	-	27260156	A375	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.03862107710828663	[476]	[552,754,523,489]	0	hSpCas9	negative selection	5805265
46046608	46046631	1	-	27260156	A375	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	0.2166414144557992	[252]	[345,287,400,330]	3	hSpCas9	negative selection	5805266
46080641	46080664	1	-	27260156	A375	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	1.3486527100804524	[59]	[110,219,259,132]	9	hSpCas9	negative selection	5805267
46080687	46080710	1	+	27260156	A375	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.7326219957517113	[591]	[954,1235,1104,1288]	9	hSpCas9	negative selection	5869517
46046570	46046593	1	+	27260156	A375	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.34515806003877625	[1078]	[1677,1900,1327,1539]	5	hSpCas9	negative selection	5869518
46062054	46062077	1	-	27260156	A375	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.2865078579686209	[217]	[209,221,286,126]	-4	hSpCas9	negative selection	5869519
46061951	46061974	1	-	27260156	COLO741	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.17523889823230737	[476]	[690,861,522]	4	hSpCas9	negative selection	5926516
46046608	46046631	1	-	27260156	COLO741	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	-0.2209171454913763	[252]	[341,233,261]	-5	hSpCas9	negative selection	5926517
46080641	46080664	1	-	27260156	COLO741	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	0.635983574020837	[59]	[110,105,137]	9	hSpCas9	negative selection	5926518
46080687	46080710	1	+	27260156	COLO741	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.2622229236497964	[591]	[894,853,964]	5	hSpCas9	negative selection	5990768
46046570	46046593	1	+	27260156	COLO741	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.06483257743414539	[1078]	[1443,1729,1169]	1	hSpCas9	negative selection	5990769
46062054	46062077	1	-	27260156	COLO741	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	0.14720613835320473	[217]	[271,289,355]	3	hSpCas9	negative selection	5990770
46061951	46061974	1	-	27260156	CAL120	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	-0.050975967999062836	[476]	[660,670,402]	0	hSpCas9	negative selection	6047767
46046608	46046631	1	-	27260156	CAL120	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	0.0840396100839762	[252]	[267,326,394]	1	hSpCas9	negative selection	6047768
46080641	46080664	1	-	27260156	CAL120	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	1.7184517693248516	[59]	[380,221,155]	9	hSpCas9	negative selection	6047769
46080687	46080710	1	+	27260156	CAL120	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.14041927078079464	[591]	[931,727,793]	2	hSpCas9	negative selection	6112019
46046570	46046593	1	+	27260156	CAL120	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.35312061533720196	[1078]	[1961,1694,1527]	5	hSpCas9	negative selection	6112020
46062054	46062077	1	-	27260156	CAL120	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.3079652692959489	[217]	[389,184,109]	-4	hSpCas9	negative selection	6112021
46061951	46061974	1	-	27260156	CADOES1	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.1554121108587882	[476]	[458,406,622,486]	2	hSpCas9	negative selection	6169018
46046608	46046631	1	-	27260156	CADOES1	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	-0.308552135077389	[252]	[197,227,170,161]	-5	hSpCas9	negative selection	6169019
46080641	46080664	1	-	27260156	CADOES1	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	1.0111583990916122	[59]	[84,154,98,110]	9	hSpCas9	negative selection	6169020
46080687	46080710	1	+	27260156	CADOES1	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.505948469158135	[591]	[712,910,720,782]	8	hSpCas9	negative selection	6233270
46046570	46046593	1	+	27260156	CADOES1	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.38596610268780207	[1078]	[1364,1309,1214,1356]	6	hSpCas9	negative selection	6233271
46062054	46062077	1	-	27260156	CADOES1	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.308845536666678	[217]	[125,151,181,195]	-5	hSpCas9	negative selection	6233272
46061951	46061974	1	-	27260156	EWS502	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.47801338322440395	[476]	[659,760,638,757]	8	hSpCas9	negative selection	6290269
46046608	46046631	1	-	27260156	EWS502	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	-0.012366697557724127	[252]	[250,199,291,327]	0	hSpCas9	negative selection	6290270
46080641	46080664	1	-	27260156	EWS502	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	1.0627671689875577	[59]	[100,146,105,182]	9	hSpCas9	negative selection	6290271
46080687	46080710	1	+	27260156	EWS502	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.22093699716754256	[591]	[659,826,669,769]	4	hSpCas9	negative selection	6354521
46046570	46046593	1	+	27260156	EWS502	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.2879425875310846	[1078]	[1452,1415,1296,1400]	5	hSpCas9	negative selection	6354522
46062054	46062077	1	-	27260156	EWS502	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.38848667706718354	[217]	[180,142,158,225]	-6	hSpCas9	negative selection	6354523
46061951	46061974	1	-	27260156	EW8	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.0021549562851624245	[476]	[466,495,274,337]	0	hSpCas9	negative selection	6411520
46046608	46046631	1	-	27260156	EW8	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	0.125924440502584	[252]	[327,156,154,276]	2	hSpCas9	negative selection	6411521
46080641	46080664	1	-	27260156	EW8	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	1.54306369305285	[59]	[332,85,66,113]	9	hSpCas9	negative selection	6411522
46080687	46080710	1	+	27260156	EW8	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.41473284959831314	[591]	[614,510,762,642]	7	hSpCas9	negative selection	6475772
46046570	46046593	1	+	27260156	EW8	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.24095848418659482	[1078]	[1170,1143,888,966]	4	hSpCas9	negative selection	6475773
46062054	46062077	1	-	27260156	EW8	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.29101683689028257	[217]	[155,224,144,52]	-5	hSpCas9	negative selection	6475774
46061951	46061974	1	-	27260156	CORL105	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.28643375165948304	[476]	[695,728,625,663]	5	hSpCas9	negative selection	6532771
46046608	46046631	1	-	27260156	CORL105	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	0.07172000970080827	[252]	[292,350,306,291]	1	hSpCas9	negative selection	6532772
46080641	46080664	1	-	27260156	CORL105	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	0.9930242849462247	[59]	[138,147,170,105]	9	hSpCas9	negative selection	6532773
46080687	46080710	1	+	27260156	CORL105	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.28191355258856254	[591]	[734,762,984,906]	5	hSpCas9	negative selection	6597023
46046570	46046593	1	+	27260156	CORL105	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.3800294322406219	[1078]	[1868,1655,1610,1441]	7	hSpCas9	negative selection	6597024
46062054	46062077	1	-	27260156	CORL105	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.10943142224914904	[217]	[175,202,377,209]	-2	hSpCas9	negative selection	6597025
46061951	46061974	1	-	27260156	HS294T	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.1809028754173771	[476]	[176,209,270,174]	2	hSpCas9	negative selection	6654022
46046608	46046631	1	-	27260156	HS294T	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	0.11048829195309806	[252]	[98,113,100,108]	1	hSpCas9	negative selection	6654023
46080641	46080664	1	-	27260156	HS294T	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	0.7749280001739969	[59]	[39,34,37,46]	8	hSpCas9	negative selection	6654024
46080687	46080710	1	+	27260156	HS294T	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.3797692894630348	[591]	[194,201,271,581]	5	hSpCas9	negative selection	6718274
46046570	46046593	1	+	27260156	HS294T	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.4444018146094255	[1078]	[390,538,749,614]	6	hSpCas9	negative selection	6718275
46062054	46062077	1	-	27260156	HS294T	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.27235628055750416	[217]	[42,66,99,71]	-4	hSpCas9	negative selection	6718276
46061951	46061974	1	-	27260156	HCC44	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	-0.11845112013776472	[476]	[405,450,703,457]	-2	hSpCas9	negative selection	6775273
46046608	46046631	1	-	27260156	HCC44	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	-0.7651109411210633	[252]	[298,94,154,143]	-8	hSpCas9	negative selection	6775274
46080641	46080664	1	-	27260156	HCC44	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	0.9739106098985901	[59]	[139,66,198,146]	9	hSpCas9	negative selection	6775275
46080687	46080710	1	+	27260156	HCC44	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.18818332722189413	[591]	[714,989,860,468]	3	hSpCas9	negative selection	6839525
46046570	46046593	1	+	27260156	HCC44	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.29135059364198357	[1078]	[2088,1297,1686,1018]	5	hSpCas9	negative selection	6839526
46062054	46062077	1	-	27260156	HCC44	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.36245240830647907	[217]	[199,132,257,194]	-5	hSpCas9	negative selection	6839527
46061951	46061974	1	-	27260156	G402	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.616141359188598	[476]	[1039,740,721,1065]	7	hSpCas9	negative selection	6896524
46046608	46046631	1	-	27260156	G402	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	0.5985839829513138	[252]	[851,437,188,443]	7	hSpCas9	negative selection	6896525
46080641	46080664	1	-	27260156	G402	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	-0.13096475151852216	[59]	[37,57,67,96]	-2	hSpCas9	negative selection	6896526
46080687	46080710	1	+	27260156	G402	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.44500652107514616	[591]	[1761,696,785,789]	5	hSpCas9	negative selection	6960776
46046570	46046593	1	+	27260156	G402	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.5598826142254358	[1078]	[1651,2226,1808,2037]	7	hSpCas9	negative selection	6960777
46062054	46062077	1	-	27260156	G402	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	0.039899248677959465	[217]	[395,283,91,335]	0	hSpCas9	negative selection	6960778
46061951	46061974	1	-	27260156	L33	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.11235772272375473	[476]	[531,219,367,408]	2	hSpCas9	negative selection	7017775
46046608	46046631	1	-	27260156	L33	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	0.2846953061255142	[252]	[278,110,197,367]	6	hSpCas9	negative selection	7017776
46080641	46080664	1	-	27260156	L33	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	0.7775168556552967	[59]	[107,59,55,67]	9	hSpCas9	negative selection	7017777
46080687	46080710	1	+	27260156	L33	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	-0.11815462681413832	[591]	[668,209,281,547]	-3	hSpCas9	negative selection	7082027
46046570	46046593	1	+	27260156	L33	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	-0.006877507185094389	[1078]	[1077,497,671,933]	0	hSpCas9	negative selection	7082028
46062054	46062077	1	-	27260156	L33	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.0013569725532625032	[217]	[163,51,103,413]	0	hSpCas9	negative selection	7082029
46061951	46061974	1	-	27260156	K562	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	-0.4872343255959321	[476]	[207,276,300,399]	-5	hSpCas9	negative selection	7139026
46046608	46046631	1	-	27260156	K562	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	-0.30585323785567664	[252]	[253,127,194,154]	-4	hSpCas9	negative selection	7139027
46080641	46080664	1	-	27260156	K562	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	0.7727176615696343	[59]	[100,171,36,61]	8	hSpCas9	negative selection	7139028
46080687	46080710	1	+	27260156	K562	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.5058330709106615	[591]	[846,1140,598,456]	6	hSpCas9	negative selection	7203278
46046570	46046593	1	+	27260156	K562	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.21478043602230668	[1078]	[1391,1192,775,1106]	2	hSpCas9	negative selection	7203279
46062054	46062077	1	-	27260156	K562	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.6375743356386401	[217]	[143,118,89,142]	-6	hSpCas9	negative selection	7203280
46061951	46061974	1	-	27260156	HT29	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.17934310929040537	[476]	[778,437,843,562]	3	hSpCas9	negative selection	7260277
46046608	46046631	1	-	27260156	HT29	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	0.1682721847448	[252]	[338,405,324,317]	3	hSpCas9	negative selection	7260278
46080641	46080664	1	-	27260156	HT29	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	0.7680788064547741	[59]	[199,57,157,84]	9	hSpCas9	negative selection	7260279
46080687	46080710	1	+	27260156	HT29	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.44018872032517664	[591]	[1062,1078,903,879]	8	hSpCas9	negative selection	7324529
46046570	46046593	1	+	27260156	HT29	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.23544856028915118	[1078]	[1574,1602,1613,1398]	4	hSpCas9	negative selection	7324530
46062054	46062077	1	-	27260156	HT29	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.054377853028751755	[217]	[274,292,256,204]	-1	hSpCas9	negative selection	7324531
46061951	46061974	1	-	27260156	MHHES1	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	-0.09624768329541858	[476]	[638,456,629,326]	-2	hSpCas9	negative selection	7381528
46046608	46046631	1	-	27260156	MHHES1	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	-0.08240847572948495	[252]	[174,358,153,357]	-1	hSpCas9	negative selection	7381529
46080641	46080664	1	-	27260156	MHHES1	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	0.9254791618109963	[59]	[120,201,112,89]	9	hSpCas9	negative selection	7381530
46080687	46080710	1	+	27260156	MHHES1	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.712694055431611	[591]	[1475,1111,1038,828]	9	hSpCas9	negative selection	7445780
46046570	46046593	1	+	27260156	MHHES1	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.22476569285990822	[1078]	[1566,1503,1590,1090]	4	hSpCas9	negative selection	7445781
46062054	46062077	1	-	27260156	MHHES1	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	0.01298732085838794	[217]	[363,310,164,180]	0	hSpCas9	negative selection	7445782
46061951	46061974	1	-	27260156	MEWO	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.36734304815134616	[476]	[640,479,618]	7	hSpCas9	negative selection	7502779
46046608	46046631	1	-	27260156	MEWO	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	-0.2346276422061182	[252]	[185,103,310]	-5	hSpCas9	negative selection	7502780
46080641	46080664	1	-	27260156	MEWO	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	0.6058960081627394	[59]	[139,53,72]	9	hSpCas9	negative selection	7502781
46080687	46080710	1	+	27260156	MEWO	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.13605932300286305	[591]	[675,567,594]	3	hSpCas9	negative selection	7567031
46046570	46046593	1	+	27260156	MEWO	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.18085943648464298	[1078]	[998,1242,1161]	4	hSpCas9	negative selection	7567032
46062054	46062077	1	-	27260156	MEWO	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.277001892707331	[217]	[193,148,166]	-6	hSpCas9	negative selection	7567033
46061951	46061974	1	-	27260156	LNCAPCLONEFGC	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.013740806638735725	[476]	[441,323,584,422]	0	hSpCas9	negative selection	7624030
46046608	46046631	1	-	27260156	LNCAPCLONEFGC	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	-0.19891137166045203	[252]	[136,136,314,231]	-3	hSpCas9	negative selection	7624031
46080641	46080664	1	-	27260156	LNCAPCLONEFGC	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	1.2179314525855485	[59]	[100,162,87,145]	9	hSpCas9	negative selection	7624032
46080687	46080710	1	+	27260156	LNCAPCLONEFGC	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.34771790620529675	[591]	[709,715,685,614]	5	hSpCas9	negative selection	7688282
46046570	46046593	1	+	27260156	LNCAPCLONEFGC	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.3398536740464191	[1078]	[1162,1224,1313,1258]	5	hSpCas9	negative selection	7688283
46062054	46062077	1	-	27260156	LNCAPCLONEFGC	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.39152074249495095	[217]	[147,162,215,83]	-6	hSpCas9	negative selection	7688284
46061951	46061974	1	-	27260156	PANC0327	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	-0.07164560256644283	[476]	[358,279,480,504]	-1	hSpCas9	negative selection	7745281
46046608	46046631	1	-	27260156	PANC0327	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	-0.4025758427228745	[252]	[146,171,225,132]	-5	hSpCas9	negative selection	7745282
46080641	46080664	1	-	27260156	PANC0327	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	1.4834246023025681	[59]	[209,109,99,185]	9	hSpCas9	negative selection	7745283
46080687	46080710	1	+	27260156	PANC0327	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.3193611479461974	[591]	[1138,415,558,580]	5	hSpCas9	negative selection	7809533
46046570	46046593	1	+	27260156	PANC0327	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.2348358196363325	[1078]	[999,1153,950,1391]	3	hSpCas9	negative selection	7809534
46062054	46062077	1	-	27260156	PANC0327	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.4232494495409158	[217]	[262,115,120,90]	-6	hSpCas9	negative selection	7809535
46061951	46061974	1	-	27260156	NCIH2009	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.2242798046733686	[476]	[806,993,534]	3	hSpCas9	negative selection	7866532
46046608	46046631	1	-	27260156	NCIH2009	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	-0.10913714907228234	[252]	[295,236,444]	-1	hSpCas9	negative selection	7866533
46080641	46080664	1	-	27260156	NCIH2009	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	1.559732440367784	[59]	[352,130,279]	9	hSpCas9	negative selection	7866534
46080687	46080710	1	+	27260156	NCIH2009	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.3956068493481748	[591]	[1275,1170,850]	5	hSpCas9	negative selection	7930784
46046570	46046593	1	+	27260156	NCIH2009	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.3405704121870976	[1078]	[2351,2024,1431]	5	hSpCas9	negative selection	7930785
46062054	46062077	1	-	27260156	NCIH2009	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	0.17484216876069703	[217]	[361,314,357]	2	hSpCas9	negative selection	7930786
46061951	46061974	1	-	27260156	NCIH1373	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	-0.37317478435819185	[476]	[488,320,315,145]	-4	hSpCas9	negative selection	7987783
46046608	46046631	1	-	27260156	NCIH1373	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	0.33935371564035965	[252]	[524,425,311,46]	3	hSpCas9	negative selection	7987784
46080641	46080664	1	-	27260156	NCIH1373	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	1.7208551453550953	[59]	[227,103,231,89]	9	hSpCas9	negative selection	7987785
46080687	46080710	1	+	27260156	NCIH1373	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.5312307578058102	[591]	[1083,893,843,273]	5	hSpCas9	negative selection	8052035
46046570	46046593	1	+	27260156	NCIH1373	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.3582218345954693	[1078]	[1811,1548,1555,341]	3	hSpCas9	negative selection	8052036
46062054	46062077	1	-	27260156	NCIH1373	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-1.3509588524810487	[217]	[168,97,46,20]	-8	hSpCas9	negative selection	8052037
46061951	46061974	1	-	27260156	PATU8902	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	-0.17205022849334245	[476]	[697,561,425,724]	-2	hSpCas9	negative selection	8109034
46046608	46046631	1	-	27260156	PATU8902	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	0.30127694084151746	[252]	[649,272,381,438]	3	hSpCas9	negative selection	8109035
46080641	46080664	1	-	27260156	PATU8902	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	1.2344015856370905	[59]	[294,322,96,80]	9	hSpCas9	negative selection	8109036
46080687	46080710	1	+	27260156	PATU8902	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.3689268881432337	[591]	[835,1248,1018,1174]	4	hSpCas9	negative selection	8173286
46046570	46046593	1	+	27260156	PATU8902	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.6238459605497386	[1078]	[1871,2627,2287,2490]	6	hSpCas9	negative selection	8173287
46062054	46062077	1	-	27260156	PATU8902	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	0.005751646189386728	[217]	[209,271,332,407]	0	hSpCas9	negative selection	8173288
46061951	46061974	1	-	27260156	PANC1	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.17277288746779096	[476]	[442,533,551,345]	2	hSpCas9	negative selection	8230285
46046608	46046631	1	-	27260156	PANC1	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	-0.29824368664403456	[252]	[109,220,155,219]	-5	hSpCas9	negative selection	8230286
46080641	46080664	1	-	27260156	PANC1	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	0.7062136400259296	[59]	[62,78,104,86]	9	hSpCas9	negative selection	8230287
46080687	46080710	1	+	27260156	PANC1	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.3567984064607751	[591]	[647,839,629,533]	6	hSpCas9	negative selection	8294537
46046570	46046593	1	+	27260156	PANC1	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.2868530195730663	[1078]	[896,1605,1288,860]	4	hSpCas9	negative selection	8294538
46062054	46062077	1	-	27260156	PANC1	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.5891436098885083	[217]	[88,206,110,108]	-7	hSpCas9	negative selection	8294539
46061951	46061974	1	-	27260156	PANC0813	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	-0.21217023293883974	[476]	[793,280,500,391]	-3	hSpCas9	negative selection	8351536
46046608	46046631	1	-	27260156	PANC0813	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	-0.2142352518649242	[252]	[295,355,200,178]	-3	hSpCas9	negative selection	8351537
46080641	46080664	1	-	27260156	PANC0813	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	0.8546286667739089	[59]	[121,88,199,99]	9	hSpCas9	negative selection	8351538
46080687	46080710	1	+	27260156	PANC0813	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.1828663079623727	[591]	[802,987,794,582]	3	hSpCas9	negative selection	8415788
46046570	46046593	1	+	27260156	PANC0813	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.2164230807634433	[1078]	[1730,1548,1377,1264]	3	hSpCas9	negative selection	8415789
46062054	46062077	1	-	27260156	PANC0813	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	0.18014187744864274	[217]	[335,201,326,298]	3	hSpCas9	negative selection	8415790
46061951	46061974	1	-	27260156	RDES	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	-0.05394677924065868	[476]	[475,483,561,602]	-1	hSpCas9	negative selection	8472787
46046608	46046631	1	-	27260156	RDES	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	-0.27699394605276195	[252]	[183,191,277,331]	-5	hSpCas9	negative selection	8472788
46080641	46080664	1	-	27260156	RDES	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	0.8555999558709493	[59]	[100,104,141,160]	9	hSpCas9	negative selection	8472789
46080687	46080710	1	+	27260156	RDES	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.5424234811904453	[591]	[711,902,1060,1395]	8	hSpCas9	negative selection	8537039
46046570	46046593	1	+	27260156	RDES	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.19689380496197195	[1078]	[985,1535,1670,1570]	3	hSpCas9	negative selection	8537040
46062054	46062077	1	-	27260156	RDES	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.639377618253776	[217]	[127,160,192,165]	-8	hSpCas9	negative selection	8537041
46061951	46061974	1	-	27260156	PC3	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.08569339508337352	[476]	[314,428,1058,468]	2	hSpCas9	negative selection	8594038
46046608	46046631	1	-	27260156	PC3	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	-0.014384952841876242	[252]	[153,176,505,285]	0	hSpCas9	negative selection	8594039
46080641	46080664	1	-	27260156	PC3	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	0.14761675779958905	[59]	[15,72,108,103]	3	hSpCas9	negative selection	8594040
46080687	46080710	1	+	27260156	PC3	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.1292199452961787	[591]	[379,602,1046,772]	3	hSpCas9	negative selection	8658290
46046570	46046593	1	+	27260156	PC3	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.23151722236117322	[1078]	[749,1477,1880,1275]	5	hSpCas9	negative selection	8658291
46062054	46062077	1	-	27260156	PC3	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.11905167193259647	[217]	[143,182,460,113]	-3	hSpCas9	negative selection	8658292
46061951	46061974	1	-	27260156	PATU8988T	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.19827616698936779	[476]	[437,624,494,569]	3	hSpCas9	negative selection	8715289
46046608	46046631	1	-	27260156	PATU8988T	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	0.019771411137463946	[252]	[154,339,186,324]	0	hSpCas9	negative selection	8715290
46080641	46080664	1	-	27260156	PATU8988T	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	0.14536874630200414	[59]	[41,38,132,36]	2	hSpCas9	negative selection	8715291
46080687	46080710	1	+	27260156	PATU8988T	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.259534626696421	[591]	[800,681,624,626]	4	hSpCas9	negative selection	8779541
46046570	46046593	1	+	27260156	PATU8988T	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.10218307890179723	[1078]	[950,1231,1311,977]	1	hSpCas9	negative selection	8779542
46062054	46062077	1	-	27260156	PATU8988T	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.19453745349226992	[217]	[148,199,218,167]	-3	hSpCas9	negative selection	8779543
46061951	46061974	1	-	27260156	T47D	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.2748233319396277	[476]	[671,582,590,857]	6	hSpCas9	negative selection	8836540
46046608	46046631	1	-	27260156	T47D	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	-0.12459842802456422	[252]	[260,238,319,262]	-3	hSpCas9	negative selection	8836541
46080641	46080664	1	-	27260156	T47D	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	0.6828887959519205	[59]	[83,115,94,154]	9	hSpCas9	negative selection	8836542
46080687	46080710	1	+	27260156	T47D	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.48207355718744893	[591]	[955,899,878,1129]	8	hSpCas9	negative selection	8900792
46046570	46046593	1	+	27260156	T47D	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.267437361520811	[1078]	[1399,1565,1356,1732]	5	hSpCas9	negative selection	8900793
46062054	46062077	1	-	27260156	T47D	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.15070418332613378	[217]	[272,236,182,221]	-3	hSpCas9	negative selection	8900794
46061951	46061974	1	-	27260156	SU8686	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	-0.1690677228696611	[476]	[380,341,434,558]	-3	hSpCas9	negative selection	8957791
46046608	46046631	1	-	27260156	SU8686	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	0.09362417758502417	[252]	[302,208,273,289]	1	hSpCas9	negative selection	8957792
46080641	46080664	1	-	27260156	SU8686	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	1.3413733755230708	[59]	[106,138,188,178]	9	hSpCas9	negative selection	8957793
46080687	46080710	1	+	27260156	SU8686	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.32547997333361633	[591]	[645,752,770,782]	5	hSpCas9	negative selection	9022043
46046570	46046593	1	+	27260156	SU8686	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.12593514142649975	[1078]	[1098,1130,1161,1302]	2	hSpCas9	negative selection	9022044
46062054	46062077	1	-	27260156	SU8686	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	0.23206007722067135	[217]	[267,235,170,352]	4	hSpCas9	negative selection	9022045
46061951	46061974	1	-	27260156	SKES1	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	-0.1221994584038723	[476]	[387,505,426,425]	-3	hSpCas9	negative selection	9079042
46046608	46046631	1	-	27260156	SKES1	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	-0.4143432750533429	[252]	[199,179,187,187]	-7	hSpCas9	negative selection	9079043
46080641	46080664	1	-	27260156	SKES1	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	1.358719018940239	[59]	[172,99,116,211]	9	hSpCas9	negative selection	9079044
46080687	46080710	1	+	27260156	SKES1	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.22838256730104323	[591]	[753,704,691,626]	5	hSpCas9	negative selection	9143294
46046570	46046593	1	+	27260156	SKES1	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.08347048764614184	[1078]	[1393,1218,935,1057]	1	hSpCas9	negative selection	9143295
46062054	46062077	1	-	27260156	SKES1	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.22367348592883451	[217]	[254,159,191,146]	-5	hSpCas9	negative selection	9143296
46061951	46061974	1	-	27260156	TOV112D	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.005207185711464727	[476]	[396,680,375,504]	0	hSpCas9	negative selection	9200293
46046608	46046631	1	-	27260156	TOV112D	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	0.18996235452563437	[252]	[224,295,158,466]	3	hSpCas9	negative selection	9200294
46080641	46080664	1	-	27260156	TOV112D	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	1.2871151219655805	[59]	[125,120,100,227]	9	hSpCas9	negative selection	9200295
46080687	46080710	1	+	27260156	TOV112D	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.3827590782258887	[591]	[735,1062,651,709]	7	hSpCas9	negative selection	9264545
46046570	46046593	1	+	27260156	TOV112D	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	-0.0056134749861640465	[1078]	[1062,1468,1059,814]	0	hSpCas9	negative selection	9264546
46062054	46062077	1	-	27260156	TOV112D	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	0.09441625199112291	[217]	[247,136,195,325]	1	hSpCas9	negative selection	9264547
46061951	46061974	1	-	27260156	TC71	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.24727059025994957	[476]	[561,722,566,575]	6	hSpCas9	negative selection	9321544
46046608	46046631	1	-	27260156	TC71	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	-0.053031268580735924	[252]	[295,257,258,229]	-1	hSpCas9	negative selection	9321545
46080641	46080664	1	-	27260156	TC71	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	0.9685394813381318	[59]	[155,96,131,116]	9	hSpCas9	negative selection	9321546
46080687	46080710	1	+	27260156	TC71	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.2653180130676088	[591]	[720,727,690,923]	6	hSpCas9	negative selection	9385796
46046570	46046593	1	+	27260156	TC71	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.16441823044090942	[1078]	[1227,1323,1227,1415]	4	hSpCas9	negative selection	9385797
46062054	46062077	1	-	27260156	TC71	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	0.18851342119854775	[217]	[330,115,248,374]	5	hSpCas9	negative selection	9385798
46061951	46061974	1	-	27260156	TC32	viability	TATTGAGCGATTTCGCAGAGAGG	PIK3R3	ENSG00000278139	0.05752924037453466	[476]	[481,347,639,438]	1	hSpCas9	negative selection	9442795
46046608	46046631	1	-	27260156	TC32	viability	GGCAGATGGCTCAATCACAAAGG	PIK3R3	ENSG00000278139	-0.14838827486813755	[252]	[263,162,233,198]	-3	hSpCas9	negative selection	9442796
46080641	46080664	1	-	27260156	TC32	viability	GGTACTGGGGGGATATTTCAAGG	PIK3R3	ENSG00000278139	0.5993509500442626	[59]	[72,64,107,104]	8	hSpCas9	negative selection	9442797
46080687	46080710	1	+	27260156	TC32	viability	GAACTGTCCTTCATTCCATTTGG	PIK3R3	ENSG00000278139	0.6365201389038746	[591]	[889,700,1100,809]	9	hSpCas9	negative selection	9507047
46046570	46046593	1	+	27260156	TC32	viability	TAATTCCCAGCCAGACATTCAGG	PIK3R3	ENSG00000278139	0.05892416408525358	[1078]	[1049,709,1359,1237]	1	hSpCas9	negative selection	9507048
46062054	46062077	1	-	27260156	TC32	viability	TGTAGGAAATACAGATGAAGAGG	PIK3R3	ENSG00000278139	-0.24115195637283593	[217]	[208,162,168,136]	-4	hSpCas9	negative selection	9507049
46055805	46055828	1	+	27869803	HPAFII	viability after 27 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	2.277536200077524	[75]	[244,150,NaN]	9	hSpCas9	negative selection	9534743
46061949	46061972	1	-	27869803	HPAFII	viability after 27 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	0.8490365699452115	[349]	[385,285,NaN]	7	hSpCas9	negative selection	9534744
46066910	46066933	1	-	27869803	HPAFII	viability after 27 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	0.8937216503596674	[387]	[528,253,NaN]	7	hSpCas9	negative selection	9534745
46077575	46077598	1	-	27869803	HPAFII	viability after 27 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	-0.3094587429251461	[38]	[15,16,NaN]	-2	hSpCas9	negative selection	9534746
46131908	46131931	1	-	27869803	HPAFII	viability after 27 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	-0.05093354561307484	[617]	[305,319,NaN]	0	hSpCas9	negative selection	9534747
46055805	46055828	1	+	27869803	HPAFII	viability after 15 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	1.2002309408064953	[75]	[154,207,NaN]	9	hSpCas9	negative selection	9617192
46061949	46061972	1	-	27869803	HPAFII	viability after 15 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	0.5284536715830387	[349]	[647,476,NaN]	6	hSpCas9	negative selection	9617193
46066910	46066933	1	-	27869803	HPAFII	viability after 15 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	0.9313214385987378	[387]	[1343,453,NaN]	8	hSpCas9	negative selection	9617194
46077575	46077598	1	-	27869803	HPAFII	viability after 15 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	-0.3947232226637043	[38]	[13,42,NaN]	-4	hSpCas9	negative selection	9617195
46131908	46131931	1	-	27869803	HPAFII	viability after 15 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	-0.8032292149054389	[617]	[416,357,NaN]	-7	hSpCas9	negative selection	9617196
46055805	46055828	1	+	27869803	ASPC1	viability after 36 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	0.29107871562855325	[246]	[71,156,86]	3	hSpCas9	negative selection	9699641
46061949	46061972	1	-	27869803	ASPC1	viability after 36 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	-0.4847316943201714	[783]	[245,259,106]	-5	hSpCas9	negative selection	9699642
46066910	46066933	1	-	27869803	ASPC1	viability after 36 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	0.9870782144776689	[883]	[633,760,470]	8	hSpCas9	negative selection	9699643
46077575	46077598	1	-	27869803	ASPC1	viability after 36 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	-2.5570548754743054	[111]	[3,15,0]	-9	hSpCas9	negative selection	9699644
46131908	46131931	1	-	27869803	ASPC1	viability after 36 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	0.33670728045377063	[1176]	[448,565,524]	3	hSpCas9	negative selection	9699645
46055805	46055828	1	+	27869803	PATU8988S	viability after 35 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	0.019598010222052986	[234]	[69,121,NaN]	0	hSpCas9	negative selection	9782090
46061949	46061972	1	-	27869803	PATU8988S	viability after 35 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	0.7704739698026637	[730]	[376,627,NaN]	7	hSpCas9	negative selection	9782091
46066910	46066933	1	-	27869803	PATU8988S	viability after 35 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	-0.3528156028866531	[835]	[330,195,NaN]	-4	hSpCas9	negative selection	9782092
46077575	46077598	1	-	27869803	PATU8988S	viability after 35 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	-0.3084853033546211	[99]	[41,22,NaN]	-3	hSpCas9	negative selection	9782093
46131908	46131931	1	-	27869803	PATU8988S	viability after 35 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	0.52138406149748	[1076]	[662,581,NaN]	6	hSpCas9	negative selection	9782094
46055805	46055828	1	+	27869803	PATU8988S	viability after 31 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	0.047331420678444536	[234]	[47,158,NaN]	0	hSpCas9	negative selection	9864539
46061949	46061972	1	-	27869803	PATU8988S	viability after 31 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	0.5909135974644344	[730]	[387,503,NaN]	7	hSpCas9	negative selection	9864540
46066910	46066933	1	-	27869803	PATU8988S	viability after 31 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	-0.7567990056775841	[835]	[191,203,NaN]	-7	hSpCas9	negative selection	9864541
46077575	46077598	1	-	27869803	PATU8988S	viability after 31 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	-0.29416583745196645	[99]	[28,36,NaN]	-3	hSpCas9	negative selection	9864542
46131908	46131931	1	-	27869803	PATU8988S	viability after 31 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	0.33486576232682796	[1076]	[560,516,NaN]	4	hSpCas9	negative selection	9864543
46055805	46055828	1	+	27869803	HPAFII	viability after 35 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	3.009512661177923	[75]	[330,285,NaN]	9	hSpCas9	negative selection	9946988
46061949	46061972	1	-	27869803	HPAFII	viability after 35 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	1.5668772572860332	[349]	[634,400,NaN]	9	hSpCas9	negative selection	9946989
46066910	46066933	1	-	27869803	HPAFII	viability after 35 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	1.4934144940309109	[387]	[751,328,NaN]	8	hSpCas9	negative selection	9946990
46077575	46077598	1	-	27869803	HPAFII	viability after 35 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	-1.3801682443645036	[38]	[0,14,NaN]	-6	hSpCas9	negative selection	9946991
46131908	46131931	1	-	27869803	HPAFII	viability after 35 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	-0.23786996638605595	[617]	[285,241,NaN]	-1	hSpCas9	negative selection	9946992
46055805	46055828	1	+	27869803	HPAFII	viability after 31 days	GATCTCGGATCTTTCGCAGCTGG	PIK3R3	ENSG00000278139	2.6038425970571812	[75]	[287,227,NaN]	9	hSpCas9	negative selection	10029437
46061949	46061972	1	-	27869803	HPAFII	viability after 31 days	TTGAGCGATTTCGCAGAGAGGGG	PIK3R3	ENSG00000278139	1.0522598880177858	[349]	[414,398,NaN]	7	hSpCas9	negative selection	10029438
46066910	46066933	1	-	27869803	HPAFII	viability after 31 days	CCCAGTGTCCAGATACCAACAGG	PIK3R3	ENSG00000278139	1.011793674876709	[387]	[585,278,NaN]	7	hSpCas9	negative selection	10029439
46077575	46077598	1	-	27869803	HPAFII	viability after 31 days	AAATTGCGGGATATGCCAGATGG	PIK3R3	ENSG00000278139	0.06614439032296326	[38]	[20,24,NaN]	0	hSpCas9	negative selection	10029440
46131908	46131931	1	-	27869803	HPAFII	viability after 31 days	TGGACCGCGATGACGCAGACTGG	PIK3R3	ENSG00000278139	-0.029640768476568713	[617]	[345,332,NaN]	0	hSpCas9	negative selection	10029441
46066989	46067012	1	+	28162770	P31FUJ	viability	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	0.1910916458249723	[608]	[816]	2	hSpCas9	negative selection	10211397
46067083	46067106	1	-	28162770	P31FUJ	viability	CTTGTTGTTCACAGGAAGGGAGG	PIK3R3	ENSG00000278139	0.5616870908728032	[176]	[306]	6	hSpCas9	negative selection	10211398
46131935	46131958	1	-	28162770	P31FUJ	viability	GCGCGATGTACAATACGGTGTGG	PIK3R3	ENSG00000278139	0.445269700698259	[149]	[239]	5	hSpCas9	negative selection	10211399
46131905	46131928	1	-	28162770	P31FUJ	viability	ACCGCGATGACGCAGACTGGAGG	PIK3R3	ENSG00000278139	0.32628166448117213	[149]	[220]	3	hSpCas9	negative selection	10211400
46045997	46046020	1	-	28162770	P31FUJ	viability	TATCAATCGAGTACAAGCAGAGG	PIK3R3	ENSG00000278139	0.0033727413534729578	[252]	[297]	0	hSpCas9	negative selection	10211401
46080694	46080717	1	-	28162770	P31FUJ	viability	AGCAGTTCCAAATGGAATGAAGG	PIK3R3	ENSG00000278139	0.1988462577093807	[366]	[494]	2	hSpCas9	negative selection	10211402
46067047	46067070	1	-	28162770	P31FUJ	viability	ATAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.3702426552902355	[184]	[280]	4	hSpCas9	negative selection	10211403
46067003	46067026	1	-	28162770	P31FUJ	viability	TCTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	0.19858990771476726	[306]	[413]	2	hSpCas9	negative selection	10211404
46066970	46066993	1	+	28162770	P31FUJ	viability	CAAGAGATTCATGGTGATAGTGG	PIK3R3	ENSG00000278139	0.6304614587938819	[751]	[1367]	7	hSpCas9	negative selection	10211405
46046576	46046599	1	-	28162770	P31FUJ	viability	GAAACGCCTGAATGTCTGGCTGG	PIK3R3	ENSG00000278139	0.8841155473647723	[230]	[500]	8	hSpCas9	negative selection	10211406
46066989	46067012	1	+	28162770	TF1	viability	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	NaN	[NaN]	[456]	1	hSpCas9	negative selection	10380763
46067083	46067106	1	-	28162770	TF1	viability	CTTGTTGTTCACAGGAAGGGAGG	PIK3R3	ENSG00000278139	NaN	[NaN]	[215]	1	hSpCas9	negative selection	10380764
46131935	46131958	1	-	28162770	TF1	viability	GCGCGATGTACAATACGGTGTGG	PIK3R3	ENSG00000278139	NaN	[NaN]	[154]	1	hSpCas9	negative selection	10380765
46131905	46131928	1	-	28162770	TF1	viability	ACCGCGATGACGCAGACTGGAGG	PIK3R3	ENSG00000278139	NaN	[NaN]	[152]	1	hSpCas9	negative selection	10380766
46045997	46046020	1	-	28162770	TF1	viability	TATCAATCGAGTACAAGCAGAGG	PIK3R3	ENSG00000278139	NaN	[NaN]	[283]	1	hSpCas9	negative selection	10380767
46080694	46080717	1	-	28162770	TF1	viability	AGCAGTTCCAAATGGAATGAAGG	PIK3R3	ENSG00000278139	NaN	[NaN]	[321]	1	hSpCas9	negative selection	10380768
46067047	46067070	1	-	28162770	TF1	viability	ATAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	NaN	[NaN]	[305]	1	hSpCas9	negative selection	10380769
46067003	46067026	1	-	28162770	TF1	viability	TCTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	NaN	[NaN]	[102]	1	hSpCas9	negative selection	10380770
46066970	46066993	1	+	28162770	TF1	viability	CAAGAGATTCATGGTGATAGTGG	PIK3R3	ENSG00000278139	NaN	[NaN]	[749]	1	hSpCas9	negative selection	10380771
46046576	46046599	1	-	28162770	TF1	viability	GAAACGCCTGAATGTCTGGCTGG	PIK3R3	ENSG00000278139	NaN	[NaN]	[462]	1	hSpCas9	negative selection	10380772
46066989	46067012	1	+	28162770	SKM1	viability	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	0.7350142621962359	[138]	[408]	7	hSpCas9	negative selection	10550129
46067083	46067106	1	-	28162770	SKM1	viability	CTTGTTGTTCACAGGAAGGGAGG	PIK3R3	ENSG00000278139	1.0696221409332025	[37]	[140]	8	hSpCas9	negative selection	10550130
46131935	46131958	1	-	28162770	SKM1	viability	GCGCGATGTACAATACGGTGTGG	PIK3R3	ENSG00000278139	0.5228267989754356	[49]	[126]	5	hSpCas9	negative selection	10550131
46131905	46131928	1	-	28162770	SKM1	viability	ACCGCGATGACGCAGACTGGAGG	PIK3R3	ENSG00000278139	0.1432328838173179	[41]	[81]	1	hSpCas9	negative selection	10550132
46045997	46046020	1	-	28162770	SKM1	viability	TATCAATCGAGTACAAGCAGAGG	PIK3R3	ENSG00000278139	0.39212310733084205	[74]	[173]	4	hSpCas9	negative selection	10550133
46080694	46080717	1	-	28162770	SKM1	viability	AGCAGTTCCAAATGGAATGAAGG	PIK3R3	ENSG00000278139	0.7773160956762206	[99]	[302]	7	hSpCas9	negative selection	10550134
46067047	46067070	1	-	28162770	SKM1	viability	ATAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.7152640606678544	[40]	[118]	7	hSpCas9	negative selection	10550135
46067003	46067026	1	-	28162770	SKM1	viability	TCTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	0.4144384978000753	[72]	[171]	4	hSpCas9	negative selection	10550136
46066970	46066993	1	+	28162770	SKM1	viability	CAAGAGATTCATGGTGATAGTGG	PIK3R3	ENSG00000278139	0.5292207036593952	[155]	[397]	5	hSpCas9	negative selection	10550137
46046576	46046599	1	-	28162770	SKM1	viability	GAAACGCCTGAATGTCTGGCTGG	PIK3R3	ENSG00000278139	0.7483140267347492	[65]	[195]	7	hSpCas9	negative selection	10550138
46066989	46067012	1	+	28162770	SKM1	viability	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	0.7350142621962359	[138]	[408]	7	hSpCas9	negative selection	10719495
46067083	46067106	1	-	28162770	SKM1	viability	CTTGTTGTTCACAGGAAGGGAGG	PIK3R3	ENSG00000278139	1.0696221409332025	[37]	[140]	8	hSpCas9	negative selection	10719496
46131935	46131958	1	-	28162770	SKM1	viability	GCGCGATGTACAATACGGTGTGG	PIK3R3	ENSG00000278139	0.5228267989754356	[49]	[126]	5	hSpCas9	negative selection	10719497
46131905	46131928	1	-	28162770	SKM1	viability	ACCGCGATGACGCAGACTGGAGG	PIK3R3	ENSG00000278139	0.1432328838173179	[41]	[81]	1	hSpCas9	negative selection	10719498
46045997	46046020	1	-	28162770	SKM1	viability	TATCAATCGAGTACAAGCAGAGG	PIK3R3	ENSG00000278139	0.39212310733084205	[74]	[173]	4	hSpCas9	negative selection	10719499
46080694	46080717	1	-	28162770	SKM1	viability	AGCAGTTCCAAATGGAATGAAGG	PIK3R3	ENSG00000278139	0.7773160956762206	[99]	[302]	7	hSpCas9	negative selection	10719500
46067047	46067070	1	-	28162770	SKM1	viability	ATAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.7152640606678544	[40]	[118]	7	hSpCas9	negative selection	10719501
46067003	46067026	1	-	28162770	SKM1	viability	TCTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	0.4144384978000753	[72]	[171]	4	hSpCas9	negative selection	10719502
46066970	46066993	1	+	28162770	SKM1	viability	CAAGAGATTCATGGTGATAGTGG	PIK3R3	ENSG00000278139	0.5292207036593952	[155]	[397]	5	hSpCas9	negative selection	10719503
46046576	46046599	1	-	28162770	SKM1	viability	GAAACGCCTGAATGTCTGGCTGG	PIK3R3	ENSG00000278139	0.7483140267347492	[65]	[195]	7	hSpCas9	negative selection	10719504
46066989	46067012	1	+	28162770	PL21	viability	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	0.2192484374370247	[599]	[303]	2	hSpCas9	negative selection	10888861
46067083	46067106	1	-	28162770	PL21	viability	CTTGTTGTTCACAGGAAGGGAGG	PIK3R3	ENSG00000278139	-0.050821959043898635	[118]	[49]	0	hSpCas9	negative selection	10888862
46131935	46131958	1	-	28162770	PL21	viability	GCGCGATGTACAATACGGTGTGG	PIK3R3	ENSG00000278139	-0.27476934076692244	[163]	[58]	-2	hSpCas9	negative selection	10888863
46131905	46131928	1	-	28162770	PL21	viability	ACCGCGATGACGCAGACTGGAGG	PIK3R3	ENSG00000278139	0.623947323395896	[163]	[109]	5	hSpCas9	negative selection	10888864
46045997	46046020	1	-	28162770	PL21	viability	TATCAATCGAGTACAAGCAGAGG	PIK3R3	ENSG00000278139	-0.8616365830973698	[333]	[79]	-5	hSpCas9	negative selection	10888865
46080694	46080717	1	-	28162770	PL21	viability	AGCAGTTCCAAATGGAATGAAGG	PIK3R3	ENSG00000278139	0.8425876098712364	[368]	[287]	7	hSpCas9	negative selection	10888866
46067047	46067070	1	-	28162770	PL21	viability	ATAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.4984808890590666	[147]	[90]	4	hSpCas9	negative selection	10888867
46067003	46067026	1	-	28162770	PL21	viability	TCTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	-1.1272223664486702	[265]	[52]	-6	hSpCas9	negative selection	10888868
46066970	46066993	1	+	28162770	PL21	viability	CAAGAGATTCATGGTGATAGTGG	PIK3R3	ENSG00000278139	0.08299454134502704	[576]	[265]	0	hSpCas9	negative selection	10888869
46046576	46046599	1	-	28162770	PL21	viability	GAAACGCCTGAATGTCTGGCTGG	PIK3R3	ENSG00000278139	-0.9079201313681329	[193]	[44]	-6	hSpCas9	negative selection	10888870
46066989	46067012	1	+	28162770	P31FUJ	viability	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	0.1910916458249723	[608]	[816]	2	hSpCas9	negative selection	11058227
46067083	46067106	1	-	28162770	P31FUJ	viability	CTTGTTGTTCACAGGAAGGGAGG	PIK3R3	ENSG00000278139	0.5616870908728032	[176]	[306]	6	hSpCas9	negative selection	11058228
46131935	46131958	1	-	28162770	P31FUJ	viability	GCGCGATGTACAATACGGTGTGG	PIK3R3	ENSG00000278139	0.445269700698259	[149]	[239]	5	hSpCas9	negative selection	11058229
46131905	46131928	1	-	28162770	P31FUJ	viability	ACCGCGATGACGCAGACTGGAGG	PIK3R3	ENSG00000278139	0.32628166448117213	[149]	[220]	3	hSpCas9	negative selection	11058230
46045997	46046020	1	-	28162770	P31FUJ	viability	TATCAATCGAGTACAAGCAGAGG	PIK3R3	ENSG00000278139	0.0033727413534729578	[252]	[297]	0	hSpCas9	negative selection	11058231
46080694	46080717	1	-	28162770	P31FUJ	viability	AGCAGTTCCAAATGGAATGAAGG	PIK3R3	ENSG00000278139	0.1988462577093807	[366]	[494]	2	hSpCas9	negative selection	11058232
46067047	46067070	1	-	28162770	P31FUJ	viability	ATAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.3702426552902355	[184]	[280]	4	hSpCas9	negative selection	11058233
46067003	46067026	1	-	28162770	P31FUJ	viability	TCTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	0.19858990771476726	[306]	[413]	2	hSpCas9	negative selection	11058234
46066970	46066993	1	+	28162770	P31FUJ	viability	CAAGAGATTCATGGTGATAGTGG	PIK3R3	ENSG00000278139	0.6304614587938819	[751]	[1367]	7	hSpCas9	negative selection	11058235
46046576	46046599	1	-	28162770	P31FUJ	viability	GAAACGCCTGAATGTCTGGCTGG	PIK3R3	ENSG00000278139	0.8841155473647723	[230]	[500]	8	hSpCas9	negative selection	11058236
46066989	46067012	1	+	28162770	OCIAML5	viability	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	1.1200464713847618	[221]	[870]	8	hSpCas9	negative selection	11227593
46067083	46067106	1	-	28162770	OCIAML5	viability	CTTGTTGTTCACAGGAAGGGAGG	PIK3R3	ENSG00000278139	0.5366305362360666	[75]	[198]	4	hSpCas9	negative selection	11227594
46131935	46131958	1	-	28162770	OCIAML5	viability	GCGCGATGTACAATACGGTGTGG	PIK3R3	ENSG00000278139	0.7768392774447561	[96]	[299]	6	hSpCas9	negative selection	11227595
46131905	46131928	1	-	28162770	OCIAML5	viability	ACCGCGATGACGCAGACTGGAGG	PIK3R3	ENSG00000278139	0.7215360676926115	[84]	[252]	6	hSpCas9	negative selection	11227596
46045997	46046020	1	-	28162770	OCIAML5	viability	TATCAATCGAGTACAAGCAGAGG	PIK3R3	ENSG00000278139	0.11755978009248436	[167]	[328]	1	hSpCas9	negative selection	11227597
46080694	46080717	1	-	28162770	OCIAML5	viability	AGCAGTTCCAAATGGAATGAAGG	PIK3R3	ENSG00000278139	1.2890939764940272	[196]	[868]	9	hSpCas9	negative selection	11227598
46067047	46067070	1	-	28162770	OCIAML5	viability	ATAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.2367426960938589	[125]	[267]	2	hSpCas9	negative selection	11227599
46067003	46067026	1	-	28162770	OCIAML5	viability	TCTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	0.3063627917404861	[167]	[374]	2	hSpCas9	negative selection	11227600
46066970	46066993	1	+	28162770	OCIAML5	viability	CAAGAGATTCATGGTGATAGTGG	PIK3R3	ENSG00000278139	1.0464146693059868	[389]	[1453]	8	hSpCas9	negative selection	11227601
46046576	46046599	1	-	28162770	OCIAML5	viability	GAAACGCCTGAATGTCTGGCTGG	PIK3R3	ENSG00000278139	0.6344619707858167	[186]	[523]	5	hSpCas9	negative selection	11227602
46066989	46067012	1	+	28162770	EOL1	viability	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	0.05349562878791869	[983]	[537]	0	hSpCas9	negative selection	11396959
46067083	46067106	1	-	28162770	EOL1	viability	CTTGTTGTTCACAGGAAGGGAGG	PIK3R3	ENSG00000278139	-0.5739057358959467	[177]	[62]	-4	hSpCas9	negative selection	11396960
46131935	46131958	1	-	28162770	EOL1	viability	GCGCGATGTACAATACGGTGTGG	PIK3R3	ENSG00000278139	-0.2907691326857922	[338]	[145]	-2	hSpCas9	negative selection	11396961
46131905	46131928	1	-	28162770	EOL1	viability	ACCGCGATGACGCAGACTGGAGG	PIK3R3	ENSG00000278139	-0.8203230206810177	[304]	[90]	-5	hSpCas9	negative selection	11396962
46045997	46046020	1	-	28162770	EOL1	viability	TATCAATCGAGTACAAGCAGAGG	PIK3R3	ENSG00000278139	0.24694192850068042	[618]	[386]	2	hSpCas9	negative selection	11396963
46080694	46080717	1	-	28162770	EOL1	viability	AGCAGTTCCAAATGGAATGAAGG	PIK3R3	ENSG00000278139	0.7771835729290051	[689]	[622]	6	hSpCas9	negative selection	11396964
46067047	46067070	1	-	28162770	EOL1	viability	ATAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.23082695580273455	[240]	[148]	2	hSpCas9	negative selection	11396965
46067003	46067026	1	-	28162770	EOL1	viability	TCTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	0.13214319097890198	[335]	[193]	1	hSpCas9	negative selection	11396966
46066970	46066993	1	+	28162770	EOL1	viability	CAAGAGATTCATGGTGATAGTGG	PIK3R3	ENSG00000278139	0.32396731003450907	[742]	[489]	3	hSpCas9	negative selection	11396967
46046576	46046599	1	-	28162770	EOL1	viability	GAAACGCCTGAATGTCTGGCTGG	PIK3R3	ENSG00000278139	1.5177778882752913	[231]	[349]	9	hSpCas9	negative selection	11396968
46066989	46067012	1	+	28162770	MOLM13	viability	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	0.9038257741493103	[770]	[1042]	7	hSpCas9	negative selection	11566325
46067083	46067106	1	-	28162770	MOLM13	viability	CTTGTTGTTCACAGGAAGGGAGG	PIK3R3	ENSG00000278139	0.2658929886376546	[198]	[172]	2	hSpCas9	negative selection	11566326
46131935	46131958	1	-	28162770	MOLM13	viability	GCGCGATGTACAATACGGTGTGG	PIK3R3	ENSG00000278139	0.38881781055338	[224]	[212]	3	hSpCas9	negative selection	11566327
46131905	46131928	1	-	28162770	MOLM13	viability	ACCGCGATGACGCAGACTGGAGG	PIK3R3	ENSG00000278139	0.3776915725730005	[263]	[247]	2	hSpCas9	negative selection	11566328
46045997	46046020	1	-	28162770	MOLM13	viability	TATCAATCGAGTACAAGCAGAGG	PIK3R3	ENSG00000278139	0.8115592555860079	[460]	[584]	6	hSpCas9	negative selection	11566329
46080694	46080717	1	-	28162770	MOLM13	viability	AGCAGTTCCAAATGGAATGAAGG	PIK3R3	ENSG00000278139	0.9587706388069286	[527]	[741]	7	hSpCas9	negative selection	11566330
46067047	46067070	1	-	28162770	MOLM13	viability	ATAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.3158862880995289	[259]	[233]	2	hSpCas9	negative selection	11566331
46067003	46067026	1	-	28162770	MOLM13	viability	TCTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	-0.03300885438810271	[299]	[211]	0	hSpCas9	negative selection	11566332
46066970	46066993	1	+	28162770	MOLM13	viability	CAAGAGATTCATGGTGATAGTGG	PIK3R3	ENSG00000278139	0.5146204318895697	[728]	[752]	4	hSpCas9	negative selection	11566333
46046576	46046599	1	-	28162770	MOLM13	viability	GAAACGCCTGAATGTCTGGCTGG	PIK3R3	ENSG00000278139	0.6992149276510343	[275]	[323]	5	hSpCas9	negative selection	11566334
46066989	46067012	1	+	28162770	HEL	viability	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	-0.021964018765038507	[622]	[392]	0	hSpCas9	negative selection	11735691
46067083	46067106	1	-	28162770	HEL	viability	CTTGTTGTTCACAGGAAGGGAGG	PIK3R3	ENSG00000278139	0.3840045636001885	[133]	[111]	3	hSpCas9	negative selection	11735692
46131935	46131958	1	-	28162770	HEL	viability	GCGCGATGTACAATACGGTGTGG	PIK3R3	ENSG00000278139	0.4750113862622905	[245]	[218]	4	hSpCas9	negative selection	11735693
46131905	46131928	1	-	28162770	HEL	viability	ACCGCGATGACGCAGACTGGAGG	PIK3R3	ENSG00000278139	-0.7188989726889766	[220]	[85]	-5	hSpCas9	negative selection	11735694
46045997	46046020	1	-	28162770	HEL	viability	TATCAATCGAGTACAAGCAGAGG	PIK3R3	ENSG00000278139	0.06248333395672845	[458]	[306]	0	hSpCas9	negative selection	11735695
46080694	46080717	1	-	28162770	HEL	viability	AGCAGTTCCAAATGGAATGAAGG	PIK3R3	ENSG00000278139	0.7896761729112796	[484]	[536]	6	hSpCas9	negative selection	11735696
46067047	46067070	1	-	28162770	HEL	viability	ATAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	-0.3169972977859158	[211]	[108]	-2	hSpCas9	negative selection	11735697
46067003	46067026	1	-	28162770	HEL	viability	TCTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	0.06129081545543777	[204]	[136]	0	hSpCas9	negative selection	11735698
46066970	46066993	1	+	28162770	HEL	viability	CAAGAGATTCATGGTGATAGTGG	PIK3R3	ENSG00000278139	0.6709883088045303	[707]	[721]	6	hSpCas9	negative selection	11735699
46046576	46046599	1	-	28162770	HEL	viability	GAAACGCCTGAATGTCTGGCTGG	PIK3R3	ENSG00000278139	-0.08250427714130781	[285]	[172]	0	hSpCas9	negative selection	11735700
46066989	46067012	1	+	28162770	MV411	viability	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	0.6394014151622931	[582]	[764]	6	hSpCas9	negative selection	11905057
46067083	46067106	1	-	28162770	MV411	viability	CTTGTTGTTCACAGGAAGGGAGG	PIK3R3	ENSG00000278139	0.7473639476481322	[98]	[139]	6	hSpCas9	negative selection	11905058
46131935	46131958	1	-	28162770	MV411	viability	GCGCGATGTACAATACGGTGTGG	PIK3R3	ENSG00000278139	0.28350680549029705	[157]	[161]	2	hSpCas9	negative selection	11905059
46131905	46131928	1	-	28162770	MV411	viability	ACCGCGATGACGCAGACTGGAGG	PIK3R3	ENSG00000278139	0.2630344058337938	[183]	[185]	2	hSpCas9	negative selection	11905060
46045997	46046020	1	-	28162770	MV411	viability	TATCAATCGAGTACAAGCAGAGG	PIK3R3	ENSG00000278139	0.40656005612799584	[282]	[315]	3	hSpCas9	negative selection	11905061
46080694	46080717	1	-	28162770	MV411	viability	AGCAGTTCCAAATGGAATGAAGG	PIK3R3	ENSG00000278139	1.3313687010628614	[408]	[866]	9	hSpCas9	negative selection	11905062
46067047	46067070	1	-	28162770	MV411	viability	ATAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.3476017127082072	[152]	[163]	3	hSpCas9	negative selection	11905063
46067003	46067026	1	-	28162770	MV411	viability	TCTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	0.24743755078277552	[207]	[207]	2	hSpCas9	negative selection	11905064
46066970	46066993	1	+	28162770	MV411	viability	CAAGAGATTCATGGTGATAGTGG	PIK3R3	ENSG00000278139	0.27897312421588216	[542]	[554]	2	hSpCas9	negative selection	11905065
46046576	46046599	1	-	28162770	MV411	viability	GAAACGCCTGAATGTCTGGCTGG	PIK3R3	ENSG00000278139	1.2708204782207257	[152]	[310]	9	hSpCas9	negative selection	11905066
46066989	46067012	1	+	28162770	MONOMAC1	viability	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	0.4171310040466292	[325]	[498]	4	hSpCas9	negative selection	12074423
46067083	46067106	1	-	28162770	MONOMAC1	viability	CTTGTTGTTCACAGGAAGGGAGG	PIK3R3	ENSG00000278139	-1.301373506874289	[85]	[39]	-7	hSpCas9	negative selection	12074424
46131935	46131958	1	-	28162770	MONOMAC1	viability	GCGCGATGTACAATACGGTGTGG	PIK3R3	ENSG00000278139	0.11229121104817513	[91]	[113]	1	hSpCas9	negative selection	12074425
46131905	46131928	1	-	28162770	MONOMAC1	viability	ACCGCGATGACGCAGACTGGAGG	PIK3R3	ENSG00000278139	0.1084656999146974	[105]	[130]	1	hSpCas9	negative selection	12074426
46045997	46046020	1	-	28162770	MONOMAC1	viability	TATCAATCGAGTACAAGCAGAGG	PIK3R3	ENSG00000278139	-0.42651869318232105	[237]	[202]	-4	hSpCas9	negative selection	12074427
46080694	46080717	1	-	28162770	MONOMAC1	viability	AGCAGTTCCAAATGGAATGAAGG	PIK3R3	ENSG00000278139	0.6856062023022876	[223]	[412]	6	hSpCas9	negative selection	12074428
46067047	46067070	1	-	28162770	MONOMAC1	viability	ATAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.040002350241295614	[83]	[98]	0	hSpCas9	negative selection	12074429
46067003	46067026	1	-	28162770	MONOMAC1	viability	TCTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	1.113836059318813	[130]	[324]	8	hSpCas9	negative selection	12074430
46066970	46066993	1	+	28162770	MONOMAC1	viability	CAAGAGATTCATGGTGATAGTGG	PIK3R3	ENSG00000278139	0.8426989051876566	[375]	[772]	7	hSpCas9	negative selection	12074431
46046576	46046599	1	-	28162770	MONOMAC1	viability	GAAACGCCTGAATGTCTGGCTGG	PIK3R3	ENSG00000278139	0.8096268832214569	[107]	[216]	7	hSpCas9	negative selection	12074432
46066989	46067012	1	+	28162770	OCIAML2	viability	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	0.35622127244124013	[104]	[744]	3	hSpCas9	negative selection	12243789
46067083	46067106	1	-	28162770	OCIAML2	viability	CTTGTTGTTCACAGGAAGGGAGG	PIK3R3	ENSG00000278139	1.9087485418291008	[15]	[332]	9	hSpCas9	negative selection	12243790
46131935	46131958	1	-	28162770	OCIAML2	viability	GCGCGATGTACAATACGGTGTGG	PIK3R3	ENSG00000278139	-0.18617643577346182	[38]	[189]	-1	hSpCas9	negative selection	12243791
46131905	46131928	1	-	28162770	OCIAML2	viability	ACCGCGATGACGCAGACTGGAGG	PIK3R3	ENSG00000278139	-0.7457370633765299	[35]	[118]	-5	hSpCas9	negative selection	12243792
46045997	46046020	1	-	28162770	OCIAML2	viability	TATCAATCGAGTACAAGCAGAGG	PIK3R3	ENSG00000278139	0.5525598021297283	[53]	[438]	5	hSpCas9	negative selection	12243793
46080694	46080717	1	-	28162770	OCIAML2	viability	AGCAGTTCCAAATGGAATGAAGG	PIK3R3	ENSG00000278139	0.6061857718086698	[79]	[674]	6	hSpCas9	negative selection	12243794
46067047	46067070	1	-	28162770	OCIAML2	viability	ATAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.07826342077147308	[26]	[157]	0	hSpCas9	negative selection	12243795
46067003	46067026	1	-	28162770	OCIAML2	viability	TCTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	-0.26026995940061054	[42]	[198]	-2	hSpCas9	negative selection	12243796
46066970	46066993	1	+	28162770	OCIAML2	viability	CAAGAGATTCATGGTGATAGTGG	PIK3R3	ENSG00000278139	0.4127852004375141	[94]	[700]	4	hSpCas9	negative selection	12243797
46046576	46046599	1	-	28162770	OCIAML2	viability	GAAACGCCTGAATGTCTGGCTGG	PIK3R3	ENSG00000278139	0.9130744672318911	[31]	[333]	8	hSpCas9	negative selection	12243798
46066989	46067012	1	+	28162770	OCIAML3	viability	GTGGTTAATGAGCTCCACCACGG	PIK3R3	ENSG00000278139	0.6846236205606488	[114]	[557]	6	hSpCas9	negative selection	12413155
46067083	46067106	1	-	28162770	OCIAML3	viability	CTTGTTGTTCACAGGAAGGGAGG	PIK3R3	ENSG00000278139	-0.31767641187691154	[44]	[108]	-2	hSpCas9	negative selection	12413156
46131935	46131958	1	-	28162770	OCIAML3	viability	GCGCGATGTACAATACGGTGTGG	PIK3R3	ENSG00000278139	0.7438619984322208	[53]	[272]	6	hSpCas9	negative selection	12413157
46131905	46131928	1	-	28162770	OCIAML3	viability	ACCGCGATGACGCAGACTGGAGG	PIK3R3	ENSG00000278139	-0.6749276357077305	[54]	[103]	-5	hSpCas9	negative selection	12413158
46045997	46046020	1	-	28162770	OCIAML3	viability	TATCAATCGAGTACAAGCAGAGG	PIK3R3	ENSG00000278139	-0.16516434152028892	[90]	[244]	-1	hSpCas9	negative selection	12413159
46080694	46080717	1	-	28162770	OCIAML3	viability	AGCAGTTCCAAATGGAATGAAGG	PIK3R3	ENSG00000278139	0.2274914640537109	[115]	[409]	2	hSpCas9	negative selection	12413160
46067047	46067070	1	-	28162770	OCIAML3	viability	ATAAAGATCTATCACCGGGATGG	PIK3R3	ENSG00000278139	0.021651657619909614	[30]	[94]	0	hSpCas9	negative selection	12413161
46067003	46067026	1	-	28162770	OCIAML3	viability	TCTGACATTTAATTCCGTGGTGG	PIK3R3	ENSG00000278139	-1.1223866126789517	[74]	[103]	-7	hSpCas9	negative selection	12413162
46066970	46066993	1	+	28162770	OCIAML3	viability	CAAGAGATTCATGGTGATAGTGG	PIK3R3	ENSG00000278139	0.2353030164721286	[176]	[628]	2	hSpCas9	negative selection	12413163
46046576	46046599	1	-	28162770	OCIAML3	viability	GAAACGCCTGAATGTCTGGCTGG	PIK3R3	ENSG00000278139	0.9057075737784821	[60]	[344]	7	hSpCas9	negative selection	12413164