| 2114286 | 2114309 | 16 | - | 26472758 | Jiyoye | viability | GGAGCACGTGGTGGACGTGGTGG | PKD1 | ENSG00000008710 | -0.05677171825391669 | [39] | [28] | 0 | hSpCas9 | negative selection | 121200 | 2110358 | 2110381 | 16 | + | 26472758 | Jiyoye | viability | GGAGCGGAAGGTGTAAGAGATGG | PKD1 | ENSG00000008710 | -0.5668294099611823 | [164] | [83] | -4 | hSpCas9 | negative selection | 121201 | 2090341 | 2090364 | 16 | - | 26472758 | Jiyoye | viability | GGAGCCCCAGGACTACGAGATGG | PKD1 | ENSG00000008710 | -0.04348602750369168 | [81] | [59] | 0 | hSpCas9 | negative selection | 121202 | 2118248 | 2118271 | 16 | + | 26472758 | Jiyoye | viability | GCAGAGGGACAGGCAGGCAAAGG | PKD1 | ENSG00000008710 | -0.07825144566436837 | [41] | [29] | 0 | hSpCas9 | negative selection | 121203 | 2115443 | 2115466 | 16 | - | 26472758 | Jiyoye | viability | GTCAGGGCCAGGGCTACCCGGGG | PKD1 | ENSG00000008710 | -0.5928246184941264 | [29] | [14] | -4 | hSpCas9 | negative selection | 121204 | 2111765 | 2111788 | 16 | + | 26472758 | Jiyoye | viability | ACTCACACCCACAGCCACGGAGG | PKD1 | ENSG00000008710 | 0.19451449818719901 | [196] | [169] | 1 | hSpCas9 | negative selection | 121205 | 2108886 | 2108909 | 16 | + | 26472758 | Jiyoye | viability | CAGTGGTAGGCCACACGCCGGGG | PKD1 | ENSG00000008710 | 1.1176687643108885 | [109] | [179] | 7 | hSpCas9 | negative selection | 121206 | 2097467 | 2097490 | 16 | + | 26472758 | Jiyoye | viability | ACTGAGCGTTCCCTCGCCGGAGG | PKD1 | ENSG00000008710 | 0.06506940468088063 | [89] | [70] | 0 | hSpCas9 | negative selection | 121207 | 2114286 | 2114309 | 16 | - | 26472758 | KBM7 | viability | GGAGCACGTGGTGGACGTGGTGG | PKD1 | ENSG00000008710 | 0.7677592226068827 | [279,192] | [201,172] | 8 | hSpCas9 | negative selection | 312318 | 2110358 | 2110381 | 16 | + | 26472758 | KBM7 | viability | GGAGCGGAAGGTGTAAGAGATGG | PKD1 | ENSG00000008710 | -0.15713260124372283 | [664,379] | [304,134] | -1 | hSpCas9 | negative selection | 312319 | 2090341 | 2090364 | 16 | - | 26472758 | KBM7 | viability | GGAGCCCCAGGACTACGAGATGG | PKD1 | ENSG00000008710 | -0.897364532212342 | [306,261] | [69,72] | -6 | hSpCas9 | negative selection | 312320 | 2118248 | 2118271 | 16 | + | 26472758 | KBM7 | viability | GCAGAGGGACAGGCAGGCAAAGG | PKD1 | ENSG00000008710 | -0.5121175856318453 | [390,277] | [119,98] | -4 | hSpCas9 | negative selection | 312321 | 2115443 | 2115466 | 16 | - | 26472758 | KBM7 | viability | GTCAGGGCCAGGGCTACCCGGGG | PKD1 | ENSG00000008710 | -0.8194792930203354 | [19,39] | [11,4] | -6 | hSpCas9 | negative selection | 312322 | 2111765 | 2111788 | 16 | + | 26472758 | KBM7 | viability | ACTCACACCCACAGCCACGGAGG | PKD1 | ENSG00000008710 | 0.5134049466293861 | [779,773] | [498,545] | 5 | hSpCas9 | negative selection | 312323 | 2108886 | 2108909 | 16 | + | 26472758 | KBM7 | viability | CAGTGGTAGGCCACACGCCGGGG | PKD1 | ENSG00000008710 | 0.2006728824692705 | [630,626] | [238,432] | 2 | hSpCas9 | negative selection | 312324 | 2097467 | 2097490 | 16 | + | 26472758 | KBM7 | viability | ACTGAGCGTTCCCTCGCCGGAGG | PKD1 | ENSG00000008710 | 0.2889539413496565 | [676,481] | [228,417] | 3 | hSpCas9 | negative selection | 312325 | 2114286 | 2114309 | 16 | - | 26472758 | Raji | viability | GGAGCACGTGGTGGACGTGGTGG | PKD1 | ENSG00000008710 | -0.9240946960995686 | [138] | [16] | -6 | hSpCas9 | negative selection | 503436 | 2110358 | 2110381 | 16 | + | 26472758 | Raji | viability | GGAGCGGAAGGTGTAAGAGATGG | PKD1 | ENSG00000008710 | -0.01972838252973981 | [248] | [56] | 0 | hSpCas9 | negative selection | 503437 | 2090341 | 2090364 | 16 | - | 26472758 | Raji | viability | GGAGCCCCAGGACTACGAGATGG | PKD1 | ENSG00000008710 | -1.1611053005523022 | [211] | [21] | -7 | hSpCas9 | negative selection | 503438 | 2118248 | 2118271 | 16 | + | 26472758 | Raji | viability | GCAGAGGGACAGGCAGGCAAAGG | PKD1 | ENSG00000008710 | -0.7427210341433418 | [136] | [18] | -5 | hSpCas9 | negative selection | 503439 | 2115443 | 2115466 | 16 | - | 26472758 | Raji | viability | GTCAGGGCCAGGGCTACCCGGGG | PKD1 | ENSG00000008710 | 1.1073835353735997 | [11] | [5] | 8 | hSpCas9 | negative selection | 503440 | 2111765 | 2111788 | 16 | + | 26472758 | Raji | viability | ACTCACACCCACAGCCACGGAGG | PKD1 | ENSG00000008710 | 0.41738556395415405 | [412] | [127] | 4 | hSpCas9 | negative selection | 503441 | 2108886 | 2108909 | 16 | + | 26472758 | Raji | viability | CAGTGGTAGGCCACACGCCGGGG | PKD1 | ENSG00000008710 | 0.17728554860375584 | [281] | [73] | 1 | hSpCas9 | negative selection | 503442 | 2097467 | 2097490 | 16 | + | 26472758 | Raji | viability | ACTGAGCGTTCCCTCGCCGGAGG | PKD1 | ENSG00000008710 | 0.20530995606285696 | [298] | [79] | 2 | hSpCas9 | negative selection | 503443 | 2114286 | 2114309 | 16 | - | 26472758 | K562 | viability | GGAGCACGTGGTGGACGTGGTGG | PKD1 | ENSG00000008710 | -1.435492177109972 | [313] | [97] | -6 | hSpCas9 | negative selection | 694554 | 2110358 | 2110381 | 16 | + | 26472758 | K562 | viability | GGAGCGGAAGGTGTAAGAGATGG | PKD1 | ENSG00000008710 | -0.9128620645236425 | [425] | [190] | -5 | hSpCas9 | negative selection | 694555 | 2090341 | 2090364 | 16 | - | 26472758 | K562 | viability | GGAGCCCCAGGACTACGAGATGG | PKD1 | ENSG00000008710 | -0.4015732064522688 | [168] | [107] | -3 | hSpCas9 | negative selection | 694556 | 2118248 | 2118271 | 16 | + | 26472758 | K562 | viability | GCAGAGGGACAGGCAGGCAAAGG | PKD1 | ENSG00000008710 | -6.821670462791325 | [267] | [1] | -9 | hSpCas9 | negative selection | 694557 | 2115443 | 2115466 | 16 | - | 26472758 | K562 | viability | GTCAGGGCCAGGGCTACCCGGGG | PKD1 | ENSG00000008710 | 1.6732620264703217 | [12] | [34] | 9 | hSpCas9 | negative selection | 694558 | 2111765 | 2111788 | 16 | + | 26472758 | K562 | viability | ACTCACACCCACAGCCACGGAGG | PKD1 | ENSG00000008710 | 0.46380866084137135 | [480] | [559] | 3 | hSpCas9 | negative selection | 694559 | 2108886 | 2108909 | 16 | + | 26472758 | K562 | viability | CAGTGGTAGGCCACACGCCGGGG | PKD1 | ENSG00000008710 | 1.1506722311732502 | [301] | [565] | 8 | hSpCas9 | negative selection | 694560 | 2097467 | 2097490 | 16 | + | 26472758 | K562 | viability | ACTGAGCGTTCCCTCGCCGGAGG | PKD1 | ENSG00000008710 | -0.3384048622983745 | [336] | [224] | -2 | hSpCas9 | negative selection | 694561 | 2097170 | 2097193 | 16 | - | 26627737 | DLD1 | viability | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | -0.06374469000443428 | [1937] | [352,825,571] | 0 | hSpCas9 | negative selection | 793078 | 2097412 | 2097435 | 16 | - | 26627737 | DLD1 | viability | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | 0.03467997969235509 | [383] | [150,101,115] | 0 | hSpCas9 | negative selection | 793079 | 2109073 | 2109096 | 16 | - | 26627737 | DLD1 | viability | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.30086020966029725 | [1276] | [490,618,386] | 3 | hSpCas9 | negative selection | 793080 | 2097170 | 2097193 | 16 | - | 26627737 | GBM cells | viability after 5 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | -0.36982828517911615 | [1164] | [489,476] | -5 | hSpCas9 | negative selection | 875393 | 2097412 | 2097435 | 16 | - | 26627737 | GBM cells | viability after 5 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | 0.6931652096691093 | [78] | [60,75] | 8 | hSpCas9 | negative selection | 875394 | 2109073 | 2109096 | 16 | - | 26627737 | GBM cells | viability after 5 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.08322279449065384 | [498] | [279,286] | 1 | hSpCas9 | negative selection | 875395 | 2097170 | 2097193 | 16 | - | 26627737 | GBM cells | viability after 13 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | -0.3931920546300396 | [1164] | [552,422] | -5 | hSpCas9 | negative selection | 957708 | 2097412 | 2097435 | 16 | - | 26627737 | GBM cells | viability after 13 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | 1.1317822693244555 | [78] | [83,101] | 9 | hSpCas9 | negative selection | 957709 | 2109073 | 2109096 | 16 | - | 26627737 | GBM cells | viability after 13 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.27284046957293273 | [498] | [416,253] | 3 | hSpCas9 | negative selection | 957710 | 2097170 | 2097193 | 16 | - | 26627737 | GBM cells | viability after 21 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | -0.6535537971967362 | [1164] | [393,409] | -5 | hSpCas9 | negative selection | 1040023 | 2097412 | 2097435 | 16 | - | 26627737 | GBM cells | viability after 21 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | 1.1422527950728172 | [78] | [100,88] | 9 | hSpCas9 | negative selection | 1040024 | 2109073 | 2109096 | 16 | - | 26627737 | GBM cells | viability after 21 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.2401667919072925 | [498] | [338,302] | 2 | hSpCas9 | negative selection | 1040025 | 2097170 | 2097193 | 16 | - | 26627737 | RPE1 | viability after 9 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | 0.7171198280370327 | [1509] | [746,815] | 5 | hSpCas9 | negative selection | 1122338 | 2097412 | 2097435 | 16 | - | 26627737 | RPE1 | viability after 9 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | 2.6780758945011405 | [165] | [229,464] | 9 | hSpCas9 | negative selection | 1122339 | 2109073 | 2109096 | 16 | - | 26627737 | RPE1 | viability after 9 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | -0.8729027609961448 | [3803] | [610,700] | -6 | hSpCas9 | negative selection | 1122340 | 2097170 | 2097193 | 16 | - | 26627737 | RPE1 | viability after 12 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | 0.36983075259769105 | [1509] | [565,479] | 2 | hSpCas9 | negative selection | 1204653 | 2097412 | 2097435 | 16 | - | 26627737 | RPE1 | viability after 12 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | 2.179691522772678 | [165] | [186,217] | 9 | hSpCas9 | negative selection | 1204654 | 2109073 | 2109096 | 16 | - | 26627737 | RPE1 | viability after 12 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | -0.593325942580631 | [3803] | [809,536] | -4 | hSpCas9 | negative selection | 1204655 | 2097170 | 2097193 | 16 | - | 26627737 | RPE1 | viability after 15 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | 0.29587269113165415 | [1509] | [446,598] | 2 | hSpCas9 | negative selection | 1286968 | 2097412 | 2097435 | 16 | - | 26627737 | RPE1 | viability after 15 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | 1.769229019034056 | [165] | [71,244] | 8 | hSpCas9 | negative selection | 1286969 | 2109073 | 2109096 | 16 | - | 26627737 | RPE1 | viability after 15 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | -0.832224129507205 | [3803] | [666,543] | -5 | hSpCas9 | negative selection | 1286970 | 2097170 | 2097193 | 16 | - | 26627737 | RPE1 | viability after 18 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | -0.15123327203757186 | [1509] | [277,461] | -1 | hSpCas9 | negative selection | 1369283 | 2097412 | 2097435 | 16 | - | 26627737 | RPE1 | viability after 18 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | 1.9629457888612305 | [165] | [76,278] | 8 | hSpCas9 | negative selection | 1369284 | 2109073 | 2109096 | 16 | - | 26627737 | RPE1 | viability after 18 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | -0.49912960110376425 | [3803] | [677,777] | -3 | hSpCas9 | negative selection | 1369285 | 2097170 | 2097193 | 16 | - | 26627737 | HeLa | viability after 8 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | 0.07586922479886815 | [1530] | [769,820,541] | 0 | hSpCas9 | negative selection | 1451598 | 2097412 | 2097435 | 16 | - | 26627737 | HeLa | viability after 8 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | 0.5456096762009165 | [182] | [63,79,187] | 5 | hSpCas9 | negative selection | 1451599 | 2109073 | 2109096 | 16 | - | 26627737 | HeLa | viability after 8 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 1.114870919901843 | [721] | [914,632,553] | 8 | hSpCas9 | negative selection | 1451600 | 2097170 | 2097193 | 16 | - | 26627737 | HeLa | viability after 12 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | -0.3849167089003527 | [1530] | [476,478,497] | -3 | hSpCas9 | negative selection | 1533913 | 2097412 | 2097435 | 16 | - | 26627737 | HeLa | viability after 12 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | 0.6725345331791823 | [182] | [62,204,82] | 5 | hSpCas9 | negative selection | 1533914 | 2109073 | 2109096 | 16 | - | 26627737 | HeLa | viability after 12 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.8888159298916843 | [721] | [602,551,503] | 7 | hSpCas9 | negative selection | 1533915 | 2097170 | 2097193 | 16 | - | 26627737 | HeLa | viability after 15 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | -0.012184287287815287 | [1530] | [507,928,401] | 0 | hSpCas9 | negative selection | 1616228 | 2097412 | 2097435 | 16 | - | 26627737 | HeLa | viability after 15 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | 0.21100719728468575 | [182] | [72,85,100] | 1 | hSpCas9 | negative selection | 1616229 | 2109073 | 2109096 | 16 | - | 26627737 | HeLa | viability after 15 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.7607593896944528 | [721] | [423,657,405] | 6 | hSpCas9 | negative selection | 1616230 | 2097170 | 2097193 | 16 | - | 26627737 | HeLa | viability after 18 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | 0.0070795794619165076 | [1530] | [369,752,401] | 0 | hSpCas9 | negative selection | 1698543 | 2097412 | 2097435 | 16 | - | 26627737 | HeLa | viability after 18 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | 0.13735109766654052 | [182] | [43,66,100] | 1 | hSpCas9 | negative selection | 1698544 | 2109073 | 2109096 | 16 | - | 26627737 | HeLa | viability after 18 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.738906874259773 | [721] | [276,535,405] | 6 | hSpCas9 | negative selection | 1698545 | 2097170 | 2097193 | 16 | - | 26627737 | HCT116 | viability after 6 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | 0.41408988168974314 | [2144] | [409,470] | 2 | hSpCas9 | negative selection | 1780858 | 2097412 | 2097435 | 16 | - | 26627737 | HCT116 | viability after 6 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | -1.0819800565815085 | [791] | [101,34] | -6 | hSpCas9 | negative selection | 1780859 | 2109073 | 2109096 | 16 | - | 26627737 | HCT116 | viability after 6 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.6568394309182535 | [1772] | [675,308] | 3 | hSpCas9 | negative selection | 1780860 | 2097170 | 2097193 | 16 | - | 26627737 | HCT116 | viability after 8 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | 0.5733835806526648 | [799] | [560,654,748] | 6 | hSpCas9 | negative selection | 1863173 | 2097412 | 2097435 | 16 | - | 26627737 | HCT116 | viability after 8 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | 1.1438743547507897 | [66] | [85,91,66] | 8 | hSpCas9 | negative selection | 1863174 | 2109073 | 2109096 | 16 | - | 26627737 | HCT116 | viability after 8 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.5274801177584889 | [797] | [596,604,697] | 5 | hSpCas9 | negative selection | 1863175 | 2097170 | 2097193 | 16 | - | 26627737 | HCT116 | viability after 9 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | 0.7343556946150467 | [2144] | [1039,883] | 5 | hSpCas9 | negative selection | 1945488 | 2097412 | 2097435 | 16 | - | 26627737 | HCT116 | viability after 9 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | -1.1591703639611644 | [791] | [130,65] | -7 | hSpCas9 | negative selection | 1945489 | 2109073 | 2109096 | 16 | - | 26627737 | HCT116 | viability after 9 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.21168530691946552 | [1772] | [316,730] | 1 | hSpCas9 | negative selection | 1945490 | 2097170 | 2097193 | 16 | - | 26627737 | HCT116 | viability after 12 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | 0.21784046856899808 | [799] | [526,550,386] | 2 | hSpCas9 | negative selection | 2027803 | 2097412 | 2097435 | 16 | - | 26627737 | HCT116 | viability after 12 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | 1.6114519490149921 | [66] | [131,81,105] | 9 | hSpCas9 | negative selection | 2027804 | 2109073 | 2109096 | 16 | - | 26627737 | HCT116 | viability after 12 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.6184355805000252 | [797] | [950,623,328] | 6 | hSpCas9 | negative selection | 2027805 | 2097170 | 2097193 | 16 | - | 26627737 | HCT116 | viability after 15 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | 0.36432254332269687 | [799] | [959,423,436] | 3 | hSpCas9 | negative selection | 2110118 | 2097412 | 2097435 | 16 | - | 26627737 | HCT116 | viability after 15 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | 0.8685788224666866 | [66] | [91,99,21] | 7 | hSpCas9 | negative selection | 2110119 | 2109073 | 2109096 | 16 | - | 26627737 | HCT116 | viability after 15 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.39487028746036845 | [797] | [1000,568,289] | 4 | hSpCas9 | negative selection | 2110120 | 2097170 | 2097193 | 16 | - | 26627737 | HCT116 | viability after 18 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | 0.12825400763614847 | [799] | [298,491,474] | 1 | hSpCas9 | negative selection | 2192433 | 2097412 | 2097435 | 16 | - | 26627737 | HCT116 | viability after 18 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | 1.387174916262425 | [66] | [101,61,91] | 8 | hSpCas9 | negative selection | 2192434 | 2109073 | 2109096 | 16 | - | 26627737 | HCT116 | viability after 18 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.7089187026598367 | [797] | [743,556,593] | 6 | hSpCas9 | negative selection | 2192435 | 2116832 | 2116855 | 16 | - | 24336569 | HL60 | viability | GTCTGCGAGCTGCAGCCCGGAGG | PKD1 | ENSG00000008710 | 0.08612351972186172 | [754] | [1695] | 0 | hSpCas9 | negative selection | 2284343 | 2117556 | 2117579 | 16 | - | 24336569 | HL60 | viability | GCAGGAGCAGTGTCAGGCCTGGG | PKD1 | ENSG00000008710 | -0.06323074525188516 | [628] | [1273] | 0 | hSpCas9 | negative selection | 2284344 | 2117612 | 2117635 | 16 | + | 24336569 | HL60 | viability | CGGTAGCAGTGCCCGTTGCCAGG | PKD1 | ENSG00000008710 | 0.7759315039283033 | [424] | [1539] | 6 | hSpCas9 | negative selection | 2284345 | 2117624 | 2117647 | 16 | - | 24336569 | HL60 | viability | ACGGAGATCTTCCCTGGCAACGG | PKD1 | ENSG00000008710 | -1.0221430096936983 | [1619] | [1687] | -7 | hSpCas9 | negative selection | 2284346 | 2117630 | 2117653 | 16 | - | 24336569 | HL60 | viability | TCGGACACGGAGATCTTCCCTGG | PKD1 | ENSG00000008710 | -0.08146410062889642 | [370] | [741] | 0 | hSpCas9 | negative selection | 2284347 | 2118049 | 2118072 | 16 | - | 24336569 | HL60 | viability | CGGAGACGGCTCCGCCGAGGTGG | PKD1 | ENSG00000008710 | 0.5265625899012829 | [392] | [1197] | 5 | hSpCas9 | negative selection | 2284348 | 2118116 | 2118139 | 16 | + | 24336569 | HL60 | viability | GAAGGCTGCTAGCTGGCCAGAGG | PKD1 | ENSG00000008710 | 0.35582426643123455 | [948] | [2569] | 3 | hSpCas9 | negative selection | 2284349 | 2118130 | 2118153 | 16 | + | 24336569 | HL60 | viability | GGCCAGAGGCCAGAGGTCCGTGG | PKD1 | ENSG00000008710 | 4.503498400092259 | [0] | [47] | 9 | hSpCas9 | negative selection | 2284350 | 2118248 | 2118271 | 16 | + | 24336569 | HL60 | viability | GCAGAGGGACAGGCAGGCAAAGG | PKD1 | ENSG00000008710 | -0.6667809412857375 | [1017] | [1356] | -6 | hSpCas9 | negative selection | 2284351 | 2135559 | 2135582 | 16 | - | 24336569 | HL60 | viability | TGCCTCTGCGGCCCAGCGCCCGG | PKD1 | ENSG00000008710 | -0.4743327805466432 | [817] | [1245] | -4 | hSpCas9 | negative selection | 2284352 | 2116832 | 2116855 | 16 | - | 24336569 | KBM7 | viability | GTCTGCGAGCTGCAGCCCGGAGG | PKD1 | ENSG00000008710 | 0.4550775147564158 | [363] | [1360] | 4 | hSpCas9 | negative selection | 2351520 | 2117556 | 2117579 | 16 | - | 24336569 | KBM7 | viability | GCAGGAGCAGTGTCAGGCCTGGG | PKD1 | ENSG00000008710 | 0.40055518154277536 | [582] | [2098] | 4 | hSpCas9 | negative selection | 2351521 | 2117612 | 2117635 | 16 | + | 24336569 | KBM7 | viability | CGGTAGCAGTGCCCGTTGCCAGG | PKD1 | ENSG00000008710 | -0.05476040276911143 | [547] | [1438] | 0 | hSpCas9 | negative selection | 2351522 | 2117624 | 2117647 | 16 | - | 24336569 | KBM7 | viability | ACGGAGATCTTCCCTGGCAACGG | PKD1 | ENSG00000008710 | -0.5116715408145796 | [862] | [1650] | -4 | hSpCas9 | negative selection | 2351523 | 2117630 | 2117653 | 16 | - | 24336569 | KBM7 | viability | TCGGACACGGAGATCTTCCCTGG | PKD1 | ENSG00000008710 | 0.20176922559905108 | [408] | [1282] | 1 | hSpCas9 | negative selection | 2351524 | 2118049 | 2118072 | 16 | - | 24336569 | KBM7 | viability | CGGAGACGGCTCCGCCGAGGTGG | PKD1 | ENSG00000008710 | -0.9223430406562508 | [336] | [484] | -6 | hSpCas9 | negative selection | 2351525 | 2118116 | 2118139 | 16 | + | 24336569 | KBM7 | viability | GAAGGCTGCTAGCTGGCCAGAGG | PKD1 | ENSG00000008710 | -0.16567799553309648 | [803] | [1954] | -1 | hSpCas9 | negative selection | 2351526 | 2118130 | 2118153 | 16 | + | 24336569 | KBM7 | viability | GGCCAGAGGCCAGAGGTCCGTGG | PKD1 | ENSG00000008710 | -1.4475791965488813 | [0] | [0] | -7 | hSpCas9 | negative selection | 2351527 | 2118248 | 2118271 | 16 | + | 24336569 | KBM7 | viability | GCAGAGGGACAGGCAGGCAAAGG | PKD1 | ENSG00000008710 | -1.566826196727542 | [478] | [440] | -8 | hSpCas9 | negative selection | 2351528 | 2135559 | 2135582 | 16 | - | 24336569 | KBM7 | viability | TGCCTCTGCGGCCCAGCGCCCGG | PKD1 | ENSG00000008710 | 0.16385551553346486 | [395] | [1209] | 1 | hSpCas9 | negative selection | 2351529 | 2101126 | 2101149 | 16 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CAGGCGCCTGCCACTACGCCGGG | PKD1 | ENSG00000008710 | 0.535464235425859 | [718,90] | [215,31] | 2 | dCas9-VP64 | positive selection | 2386859 | 2120739 | 2120762 | 16 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CAGGAGTGAGCCACCGTGCCCGG | PKD1 | ENSG00000008710 | -0.21542961903399005 | [276,86] | [54,10] | -1 | dCas9-VP64 | positive selection | 2388483 | 2101126 | 2101149 | 16 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CAGGCGCCTGCCACTACGCCGGG | PKD1 | ENSG00000008710 | -0.3318057288001406 | [240,185] | [44,64] | -3 | dCas9-VP64 | positive selection | 2482114 | 2120739 | 2120762 | 16 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CAGGAGTGAGCCACCGTGCCCGG | PKD1 | ENSG00000008710 | -0.36417141382431395 | [64,32] | [9,14] | -4 | dCas9-VP64 | positive selection | 2483738 | 2135474 | 2135497 | 16 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | ACAGCGCTGTGGCGTCCGCGGGG | PKD1 | ENSG00000008710 | 0.024630324224773403 | [1,1] | [2,0] | 0 | hSpCas9 | positive selection | 3011548 | 2110219 | 2110242 | 16 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | CTACTTCCCCACCAACCACACGG | PKD1 | ENSG00000008710 | 0.7827815975044494 | [3,4] | [4,7] | 9 | hSpCas9 | positive selection | 3011549 | 2117877 | 2117900 | 16 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | GCTCTCGTCACTCTGCACCGAGG | PKD1 | ENSG00000008710 | 0.2803048975170971 | [2,2] | [2,3] | 6 | hSpCas9 | positive selection | 3011550 | 2135474 | 2135497 | 16 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | ACAGCGCTGTGGCGTCCGCGGGG | PKD1 | ENSG00000008710 | -0.7510496876741163 | [1,1] | [0,0] | -8 | hSpCas9 | positive selection | 3079406 | 2110219 | 2110242 | 16 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | CTACTTCCCCACCAACCACACGG | PKD1 | ENSG00000008710 | 0.230915114885057 | [3,3] | [3,2] | 4 | hSpCas9 | positive selection | 3079407 | 2117877 | 2117900 | 16 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | GCTCTCGTCACTCTGCACCGAGG | PKD1 | ENSG00000008710 | -0.2514883033743187 | [2,2] | [2,0] | -4 | hSpCas9 | positive selection | 3079408 | 2135557 | 2135580 | | + | 24336571 | A375 | resistance to PLX after 7 days | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | 0.012646788082899985 | [2,3] | [3,2] | 0 | hSpCas9 | positive selection | 3135814 | 2135591 | 2135614 | | + | 24336571 | A375 | resistance to PLX after 7 days | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 0.15695293206824612 | [6,6] | [8,6] | 5 | hSpCas9 | positive selection | 3135815 | 2135557 | 2135580 | | + | 24336571 | A375 | resistance to PLX after 14 days | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | 0.08001996458549532 | [4,3] | [1,1] | 0 | hSpCas9 | positive selection | 3193607 | 2135591 | 2135614 | | + | 24336571 | A375 | resistance to PLX after 14 days | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | -0.07711341614675893 | [7,4] | [2,1] | -1 | hSpCas9 | positive selection | 3193608 | 2135557 | 2135580 | | + | 24336571 | A375 | viability after 7 days | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.8070847953123372 | [6] | [2,3] | -8 | hSpCas9 | negative selection | 3251400 | 2135591 | 2135614 | | + | 24336571 | A375 | viability after 7 days | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | -0.4028059131226613 | [9] | [6,6] | -5 | hSpCas9 | negative selection | 3251401 | 2135557 | 2135580 | | + | 24336571 | A375 | viability after 14 days | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.4498412405860348 | [6] | [4,3] | -5 | hSpCas9 | negative selection | 3309193 | 2135591 | 2135614 | | + | 24336571 | A375 | viability after 14 days | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | -0.570217800177186 | [9] | [7,4] | -6 | hSpCas9 | negative selection | 3309194 | 2119147 | 2119170 | 16 | - | 27383988 | 293T | resistance to West Nile virus (flavivirus) | AAGATTTCTACGTTAGAAGAAGG | PKD1 | ENSG00000008710 | 4.935398116558472 | [4,4] | [0,0] | 9 | hSpCas9 | positive selection | 3386017 | 2135662 | 2135685 | 16 | - | 27383988 | 293T | resistance to West Nile virus (flavivirus) | GCCCGCCGCGCCCGCCCGCCTGG | PKD1 | ENSG00000008710 | 0.9174762085612103 | [80,80] | [0,0] | 4 | hSpCas9 | positive selection | 3386018 | 2135473 | 2135496 | 16 | + | 26780180 | HT29 | viability (Avana library 4 designs) | ACAGCGCTGTGGCGTCCGCGGGG | PKD1 | ENSG00000008710 | 3.21054789356486 | [] | [] | 8 | hSpCas9 | negative selection | 3449637 | 2110219 | 2110242 | 16 | - | 26780180 | HT29 | viability (Avana library 4 designs) | CTACTTCCCCACCAACCACACGG | PKD1 | ENSG00000008710 | 1.38965461550695 | [] | [] | 5 | hSpCas9 | negative selection | 3449638 | 2117876 | 2117899 | 16 | + | 26780180 | HT29 | viability (Avana library 4 designs) | GCTCTCGTCACTCTGCACCGAGG | PKD1 | ENSG00000008710 | 2.48626643628223 | [] | [] | 8 | hSpCas9 | negative selection | 3449639 | 2110219 | 2110242 | 16 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | CTACTTCCCCACCAACCACACGG | PKD1 | ENSG00000008710 | -7.3753487610354 | [] | [] | -6 | hSpCas9 | negative selection | 3544493 | 2117876 | 2117899 | 16 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GCTCTCGTCACTCTGCACCGAGG | PKD1 | ENSG00000008710 | -5.40059312781624 | [] | [] | -5 | hSpCas9 | negative selection | 3544494 | 2135473 | 2135496 | 16 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | ACAGCGCTGTGGCGTCCGCGGGG | PKD1 | ENSG00000008710 | -6.28711266268512 | [] | [] | -6 | hSpCas9 | negative selection | 3544495 | 2117833 | 2117856 | 16 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | CCTCCAGGCCTGAACCACCGCGG | PKD1 | ENSG00000008710 | -10.4881196495624 | [] | [] | -8 | hSpCas9 | negative selection | 3544496 | 2117850 | 2117873 | 16 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GACCTCAGCATCCAGAACCGCGG | PKD1 | ENSG00000008710 | -7.38452991726454 | [] | [] | -6 | hSpCas9 | negative selection | 3544497 | 2110219 | 2110242 | 16 | - | 26780180 | A375 | viability (Avana lentiGuide) | CTACTTCCCCACCAACCACACGG | PKD1 | ENSG00000008710 | 5.1341705155955 | [] | [] | 4 | hSpCas9 | negative selection | 3653152 | 2117876 | 2117899 | 16 | + | 26780180 | A375 | viability (Avana lentiGuide) | GCTCTCGTCACTCTGCACCGAGG | PKD1 | ENSG00000008710 | 9.97024673551004 | [] | [] | 7 | hSpCas9 | negative selection | 3653153 | 2135473 | 2135496 | 16 | + | 26780180 | A375 | viability (Avana lentiGuide) | ACAGCGCTGTGGCGTCCGCGGGG | PKD1 | ENSG00000008710 | 29.5107269285547 | [] | [] | 9 | hSpCas9 | negative selection | 3653154 | 2117833 | 2117856 | 16 | + | 26780180 | A375 | viability (Avana lentiGuide) | CCTCCAGGCCTGAACCACCGCGG | PKD1 | ENSG00000008710 | 23.5019331468603 | [] | [] | 9 | hSpCas9 | negative selection | 3653155 | 2117850 | 2117873 | 16 | - | 26780180 | A375 | viability (Avana lentiGuide) | GACCTCAGCATCCAGAACCGCGG | PKD1 | ENSG00000008710 | 19.216933015089 | [] | [] | 8 | hSpCas9 | negative selection | 3653156 | 2110219 | 2110242 | 16 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | CTACTTCCCCACCAACCACACGG | PKD1 | ENSG00000008710 | -0.9625677786064666 | [4] | [1,1] | -8 | hSpCas9 | positive selection | 3761811 | 2117876 | 2117899 | 16 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GCTCTCGTCACTCTGCACCGAGG | PKD1 | ENSG00000008710 | -0.6316476932791671 | [4] | [3,1] | -7 | hSpCas9 | positive selection | 3761812 | 2135473 | 2135496 | 16 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | ACAGCGCTGTGGCGTCCGCGGGG | PKD1 | ENSG00000008710 | -0.3332510175838981 | [4] | [3,3] | -5 | hSpCas9 | positive selection | 3761813 | 2117833 | 2117856 | 16 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | CCTCCAGGCCTGAACCACCGCGG | PKD1 | ENSG00000008710 | -1.1258264100991981 | [4] | [0,1] | -9 | hSpCas9 | positive selection | 3761814 | 2117850 | 2117873 | 16 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GACCTCAGCATCCAGAACCGCGG | PKD1 | ENSG00000008710 | -0.5822778407120829 | [4] | [1,3] | -7 | hSpCas9 | positive selection | 3761815 | 2110219 | 2110242 | 16 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | CTACTTCCCCACCAACCACACGG | PKD1 | ENSG00000008710 | 0.06414103473111764 | [5] | [5,4] | 1 | hSpCas9 | positive selection | 3870418 | 2117876 | 2117899 | 16 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GCTCTCGTCACTCTGCACCGAGG | PKD1 | ENSG00000008710 | -2.4626644958545425 | [5] | [0,0] | -9 | hSpCas9 | positive selection | 3870419 | 2135473 | 2135496 | 16 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | ACAGCGCTGTGGCGTCCGCGGGG | PKD1 | ENSG00000008710 | -1.107016589545403 | [4] | [1,0] | -8 | hSpCas9 | positive selection | 3870420 | 2117833 | 2117856 | 16 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | CCTCCAGGCCTGAACCACCGCGG | PKD1 | ENSG00000008710 | -1.027114351997682 | [4] | [0,2] | -8 | hSpCas9 | positive selection | 3870421 | 2117850 | 2117873 | 16 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GACCTCAGCATCCAGAACCGCGG | PKD1 | ENSG00000008710 | -1.2713834899668228 | [4] | [0,1] | -9 | hSpCas9 | positive selection | 3870422 | 2135557 | 2135580 | 16 | + | 26780180 | A375 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | 1.17180849580486 | [] | [] | 6 | hSpCas9 | negative selection | 3981230 | 2135591 | 2135614 | 16 | + | 26780180 | A375 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 1.01502077702309 | [] | [] | 5 | hSpCas9 | negative selection | 3981231 | 2135557 | 2135580 | 16 | + | 26780180 | HT29 | viability (GeCKOv2 library) | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | 1.7116081162626 | [] | [] | 8 | hSpCas9 | negative selection | 4089196 | 2135591 | 2135614 | 16 | + | 26780180 | HT29 | viability (GeCKOv2 library) | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 1.33511303836414 | [] | [] | 6 | hSpCas9 | negative selection | 4089197 | 2135557 | 2135580 | 16 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.6545067027637086 | [2] | [0,0] | -9 | hSpCas9 | positive selection | 4160788 | 2135591 | 2135614 | 16 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | -0.3592996656100276 | [3] | [1,0] | -7 | hSpCas9 | positive selection | 4160789 | 2135557 | 2135580 | 16 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiGuide) | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.4566812195046943 | [3] | [1,0,0,0] | -6 | hSpCas9 | positive selection | 4224810 | 2135591 | 2135614 | 16 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiGuide) | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 0.23685951517098347 | [2] | [4,0,1,0] | 1 | hSpCas9 | positive selection | 4224811 | 2135557 | 2135580 | 16 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.13574844237181488 | [1] | [1,0] | -3 | hSpCas9 | positive selection | 4290438 | 2135591 | 2135614 | 16 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 0.07764905862573215 | [2] | [2,1] | 1 | hSpCas9 | positive selection | 4290439 | 2109073 | 2109095 | 16 | - | 27760321 | OCIAML3 | viability | GACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.5431466033092748 | [702,598] | [590,932] | 6 | hSpCas9 | negative selection | 4428083 | 2110318 | 2110340 | 16 | - | 27760321 | OCIAML3 | viability | ATCGTCACGGCTGAGAACGAGG | PKD1 | ENSG00000008710 | 0.2570441393180049 | [641,517] | [519,563] | 3 | hSpCas9 | negative selection | 4428084 | 2110492 | 2110514 | 16 | - | 27760321 | OCIAML3 | viability | GTCGTCAATGCAAGCCGCACGG | PKD1 | ENSG00000008710 | 0.049046706032511045 | [729,727] | [556,636] | 0 | hSpCas9 | negative selection | 4428085 | 2111438 | 2111460 | 16 | - | 27760321 | OCIAML3 | viability | GACGGGCGACAACATCACGTGG | PKD1 | ENSG00000008710 | -0.07566796836199718 | [1472,1130] | [711,1280] | -1 | hSpCas9 | negative selection | 4428086 | 2111540 | 2111562 | 16 | + | 27760321 | OCIAML3 | viability | AAAGACGCGCACATCCGCCTGG | PKD1 | ENSG00000008710 | -0.07736891517449673 | [1008,789] | [729,573] | -1 | hSpCas9 | negative selection | 4428087 | 2109073 | 2109095 | 16 | - | 27760321 | OCIAML2 | viability | GACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.42680596363354917 | [702,598] | [636,795] | 6 | hSpCas9 | negative selection | 4511546 | 2110318 | 2110340 | 16 | - | 27760321 | OCIAML2 | viability | ATCGTCACGGCTGAGAACGAGG | PKD1 | ENSG00000008710 | 0.21995353804185153 | [641,517] | [536,551] | 3 | hSpCas9 | negative selection | 4511547 | 2110492 | 2110514 | 16 | - | 27760321 | OCIAML2 | viability | GTCGTCAATGCAAGCCGCACGG | PKD1 | ENSG00000008710 | 0.22406205392204814 | [729,727] | [627,773] | 3 | hSpCas9 | negative selection | 4511548 | 2111438 | 2111460 | 16 | - | 27760321 | OCIAML2 | viability | GACGGGCGACAACATCACGTGG | PKD1 | ENSG00000008710 | -0.33814584003315495 | [1472,1130] | [750,926] | -4 | hSpCas9 | negative selection | 4511549 | 2111540 | 2111562 | 16 | + | 27760321 | OCIAML2 | viability | AAAGACGCGCACATCCGCCTGG | PKD1 | ENSG00000008710 | 0.1190514478000555 | [1008,789] | [645,967] | 1 | hSpCas9 | negative selection | 4511550 | 2109073 | 2109095 | 16 | - | 27760321 | MV411 | viability | GACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 1.246649632533288 | [702,598] | [1075,925] | 8 | hSpCas9 | negative selection | 4595009 | 2110318 | 2110340 | 16 | - | 27760321 | MV411 | viability | ATCGTCACGGCTGAGAACGAGG | PKD1 | ENSG00000008710 | 0.9981821924539 | [641,517] | [908,536] | 7 | hSpCas9 | negative selection | 4595010 | 2110492 | 2110514 | 16 | - | 27760321 | MV411 | viability | GTCGTCAATGCAAGCCGCACGG | PKD1 | ENSG00000008710 | 0.07446746370318724 | [729,727] | [456,584] | 0 | hSpCas9 | negative selection | 4595011 | 2111438 | 2111460 | 16 | - | 27760321 | MV411 | viability | GACGGGCGACAACATCACGTGG | PKD1 | ENSG00000008710 | 0.3212296551425755 | [1472,1130] | [367,2112] | 2 | hSpCas9 | negative selection | 4595012 | 2111540 | 2111562 | 16 | + | 27760321 | MV411 | viability | AAAGACGCGCACATCCGCCTGG | PKD1 | ENSG00000008710 | 0.8737598116333121 | [1008,789] | [838,1442] | 6 | hSpCas9 | negative selection | 4595013 | 2109073 | 2109095 | 16 | - | 27760321 | HL60 | viability | GACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.30906606678898485 | [702,598] | [645,667] | 4 | hSpCas9 | negative selection | 4678472 | 2110318 | 2110340 | 16 | - | 27760321 | HL60 | viability | ATCGTCACGGCTGAGAACGAGG | PKD1 | ENSG00000008710 | 0.5735265878989981 | [641,517] | [740,658] | 6 | hSpCas9 | negative selection | 4678473 | 2110492 | 2110514 | 16 | - | 27760321 | HL60 | viability | GTCGTCAATGCAAGCCGCACGG | PKD1 | ENSG00000008710 | -0.3052937537243199 | [729,727] | [481,484] | -3 | hSpCas9 | negative selection | 4678474 | 2111438 | 2111460 | 16 | - | 27760321 | HL60 | viability | GACGGGCGACAACATCACGTGG | PKD1 | ENSG00000008710 | -0.47396134311509197 | [1472,1130] | [743,776] | -5 | hSpCas9 | negative selection | 4678475 | 2111540 | 2111562 | 16 | + | 27760321 | HL60 | viability | AAAGACGCGCACATCCGCCTGG | PKD1 | ENSG00000008710 | 0.3498608165474315 | [1008,789] | [901,959] | 4 | hSpCas9 | negative selection | 4678476 | 2109073 | 2109095 | 16 | - | 27760321 | HT1080 | viability | GACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | -0.4420060209790274 | [598,467] | [144,168] | -2 | hSpCas9 | negative selection | 4761935 | 2110318 | 2110340 | 16 | - | 27760321 | HT1080 | viability | ATCGTCACGGCTGAGAACGAGG | PKD1 | ENSG00000008710 | -0.6387827090847065 | [517,403] | [42,199] | -3 | hSpCas9 | negative selection | 4761936 | 2110492 | 2110514 | 16 | - | 27760321 | HT1080 | viability | GTCGTCAATGCAAGCCGCACGG | PKD1 | ENSG00000008710 | 1.35867475817559 | [727,567] | [819,488] | 7 | hSpCas9 | negative selection | 4761937 | 2111438 | 2111460 | 16 | - | 27760321 | HT1080 | viability | GACGGGCGACAACATCACGTGG | PKD1 | ENSG00000008710 | -0.8120874706061056 | [1130,882] | [164,297] | -3 | hSpCas9 | negative selection | 4761938 | 2111540 | 2111562 | 16 | + | 27760321 | HT1080 | viability | AAAGACGCGCACATCCGCCTGG | PKD1 | ENSG00000008710 | -0.6498727173639702 | [789,616] | [254,94] | -3 | hSpCas9 | negative selection | 4761939 | 2109073 | 2109095 | 16 | - | 27760321 | HT29 | viability after 7 days | GACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.41300057188752537 | [598,467] | [831,1073,823] | 6 | hSpCas9 | negative selection | 4845398 | 2110318 | 2110340 | 16 | - | 27760321 | HT29 | viability after 7 days | ATCGTCACGGCTGAGAACGAGG | PKD1 | ENSG00000008710 | 0.13652968555026057 | [517,403] | [559,615,760] | 2 | hSpCas9 | negative selection | 4845399 | 2110492 | 2110514 | 16 | - | 27760321 | HT29 | viability after 7 days | GTCGTCAATGCAAGCCGCACGG | PKD1 | ENSG00000008710 | -0.020756155499531137 | [727,567] | [929,726,820] | 0 | hSpCas9 | negative selection | 4845400 | 2111438 | 2111460 | 16 | - | 27760321 | HT29 | viability after 7 days | GACGGGCGACAACATCACGTGG | PKD1 | ENSG00000008710 | 0.332574129613342 | [1130,882] | [1830,1472,1613] | 5 | hSpCas9 | negative selection | 4845401 | 2111540 | 2111562 | 16 | + | 27760321 | HT29 | viability after 7 days | AAAGACGCGCACATCCGCCTGG | PKD1 | ENSG00000008710 | 0.11860864519975167 | [789,616] | [1263,836,886] | 1 | hSpCas9 | negative selection | 4845402 | 2109073 | 2109095 | 16 | - | 27760321 | HT29 | viability after 25 days | GACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.47538460321181275 | [598,467] | [748,882,923] | 5 | hSpCas9 | negative selection | 4928861 | 2110318 | 2110340 | 16 | - | 27760321 | HT29 | viability after 25 days | ATCGTCACGGCTGAGAACGAGG | PKD1 | ENSG00000008710 | 0.33271632917353966 | [517,403] | [604,776,604] | 3 | hSpCas9 | negative selection | 4928862 | 2110492 | 2110514 | 16 | - | 27760321 | HT29 | viability after 25 days | GTCGTCAATGCAAGCCGCACGG | PKD1 | ENSG00000008710 | 0.4852290341438026 | [727,567] | [734,1038,1389] | 5 | hSpCas9 | negative selection | 4928863 | 2111438 | 2111460 | 16 | - | 27760321 | HT29 | viability after 25 days | GACGGGCGACAACATCACGTGG | PKD1 | ENSG00000008710 | 0.055988342551339665 | [1130,882] | [963,1475,1157] | 0 | hSpCas9 | negative selection | 4928864 | 2111540 | 2111562 | 16 | + | 27760321 | HT29 | viability after 25 days | AAAGACGCGCACATCCGCCTGG | PKD1 | ENSG00000008710 | 0.2531465387284426 | [789,616] | [714,1219,952] | 2 | hSpCas9 | negative selection | 4928865 | 2109073 | 2109095 | 16 | - | 27760321 | HT29 | viability after 22 days | GACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.22814819793847307 | [598,467] | [908,565,686] | 2 | hSpCas9 | negative selection | 5012324 | 2110318 | 2110340 | 16 | - | 27760321 | HT29 | viability after 22 days | ATCGTCACGGCTGAGAACGAGG | PKD1 | ENSG00000008710 | 0.23963711207936633 | [517,403] | [711,582,589] | 2 | hSpCas9 | negative selection | 5012325 | 2110492 | 2110514 | 16 | - | 27760321 | HT29 | viability after 22 days | GTCGTCAATGCAAGCCGCACGG | PKD1 | ENSG00000008710 | 0.4801747894460253 | [727,567] | [1189,1088,849] | 5 | hSpCas9 | negative selection | 5012326 | 2111438 | 2111460 | 16 | - | 27760321 | HT29 | viability after 22 days | GACGGGCGACAACATCACGTGG | PKD1 | ENSG00000008710 | 0.011610017615105273 | [1130,882] | [1063,1142,1317] | 0 | hSpCas9 | negative selection | 5012327 | 2111540 | 2111562 | 16 | + | 27760321 | HT29 | viability after 22 days | AAAGACGCGCACATCCGCCTGG | PKD1 | ENSG00000008710 | -0.1603869146462309 | [789,616] | [652,931,598] | -2 | hSpCas9 | negative selection | 5012328 | 2109073 | 2109095 | 16 | - | 27760321 | HT29 | viability after 19 days | GACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.28387150840062325 | [598,467] | [1093,537,636] | 2 | hSpCas9 | negative selection | 5095787 | 2110318 | 2110340 | 16 | - | 27760321 | HT29 | viability after 19 days | ATCGTCACGGCTGAGAACGAGG | PKD1 | ENSG00000008710 | 0.45992784851168955 | [517,403] | [980,822,409] | 4 | hSpCas9 | negative selection | 5095788 | 2110492 | 2110514 | 16 | - | 27760321 | HT29 | viability after 19 days | GTCGTCAATGCAAGCCGCACGG | PKD1 | ENSG00000008710 | 0.560688168425471 | [727,567] | [828,983,1424] | 5 | hSpCas9 | negative selection | 5095789 | 2111438 | 2111460 | 16 | - | 27760321 | HT29 | viability after 19 days | GACGGGCGACAACATCACGTGG | PKD1 | ENSG00000008710 | 0.04821328781243417 | [1130,882] | [1282,1445,864] | 0 | hSpCas9 | negative selection | 5095790 | 2111540 | 2111562 | 16 | + | 27760321 | HT29 | viability after 19 days | AAAGACGCGCACATCCGCCTGG | PKD1 | ENSG00000008710 | 0.029660801884902277 | [789,616] | [745,1007,705] | 0 | hSpCas9 | negative selection | 5095791 | 2109073 | 2109095 | 16 | - | 27760321 | HT29 | viability after 16 days | GACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.17566836574197808 | [598,467] | [711,754,556] | 2 | hSpCas9 | negative selection | 5179250 | 2110318 | 2110340 | 16 | - | 27760321 | HT29 | viability after 16 days | ATCGTCACGGCTGAGAACGAGG | PKD1 | ENSG00000008710 | -0.06885787850262703 | [517,403] | [638,451,398] | 0 | hSpCas9 | negative selection | 5179251 | 2110492 | 2110514 | 16 | - | 27760321 | HT29 | viability after 16 days | GTCGTCAATGCAAGCCGCACGG | PKD1 | ENSG00000008710 | 0.3346283535932464 | [727,567] | [991,947,808] | 3 | hSpCas9 | negative selection | 5179252 | 2111438 | 2111460 | 16 | - | 27760321 | HT29 | viability after 16 days | GACGGGCGACAACATCACGTGG | PKD1 | ENSG00000008710 | 0.22256399063128485 | [1130,882] | [930,1556,1412] | 2 | hSpCas9 | negative selection | 5179253 | 2111540 | 2111562 | 16 | + | 27760321 | HT29 | viability after 16 days | AAAGACGCGCACATCCGCCTGG | PKD1 | ENSG00000008710 | -0.08239752057063532 | [789,616] | [891,749,601] | -1 | hSpCas9 | negative selection | 5179254 | 2109073 | 2109095 | 16 | - | 27760321 | HT29 | viability after 13 days | GACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.1251998828126344 | [598,467] | [791,577,655] | 1 | hSpCas9 | negative selection | 5262713 | 2110318 | 2110340 | 16 | - | 27760321 | HT29 | viability after 13 days | ATCGTCACGGCTGAGAACGAGG | PKD1 | ENSG00000008710 | 0.11060324945779476 | [517,403] | [625,477,624] | 1 | hSpCas9 | negative selection | 5262714 | 2110492 | 2110514 | 16 | - | 27760321 | HT29 | viability after 13 days | GTCGTCAATGCAAGCCGCACGG | PKD1 | ENSG00000008710 | 0.438759964857099 | [727,567] | [1080,999,977] | 5 | hSpCas9 | negative selection | 5262715 | 2111438 | 2111460 | 16 | - | 27760321 | HT29 | viability after 13 days | GACGGGCGACAACATCACGTGG | PKD1 | ENSG00000008710 | 0.13611919481911938 | [1130,882] | [1346,1234,1269] | 1 | hSpCas9 | negative selection | 5262716 | 2111540 | 2111562 | 16 | + | 27760321 | HT29 | viability after 13 days | AAAGACGCGCACATCCGCCTGG | PKD1 | ENSG00000008710 | 0.28718649926536877 | [789,616] | [855,1221,914] | 3 | hSpCas9 | negative selection | 5262717 | 2109073 | 2109095 | 16 | - | 27760321 | HT29 | viability after 10 days | GACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.0908644150732496 | [598,467] | [739,730,658] | 1 | hSpCas9 | negative selection | 5346176 | 2110318 | 2110340 | 16 | - | 27760321 | HT29 | viability after 10 days | ATCGTCACGGCTGAGAACGAGG | PKD1 | ENSG00000008710 | 0.4821782787629454 | [517,403] | [841,1071,511] | 6 | hSpCas9 | negative selection | 5346177 | 2110492 | 2110514 | 16 | - | 27760321 | HT29 | viability after 10 days | GTCGTCAATGCAAGCCGCACGG | PKD1 | ENSG00000008710 | 0.1690716286235623 | [727,567] | [699,1007,1020] | 2 | hSpCas9 | negative selection | 5346178 | 2111438 | 2111460 | 16 | - | 27760321 | HT29 | viability after 10 days | GACGGGCGACAACATCACGTGG | PKD1 | ENSG00000008710 | 0.1603554488667478 | [1130,882] | [1177,1362,1666] | 2 | hSpCas9 | negative selection | 5346179 | 2111540 | 2111562 | 16 | + | 27760321 | HT29 | viability after 10 days | AAAGACGCGCACATCCGCCTGG | PKD1 | ENSG00000008710 | -0.032656684842014116 | [789,616] | [750,1105,728] | 0 | hSpCas9 | negative selection | 5346180 | 2109073 | 2109095 | 16 | - | 27760321 | MOLM13 | viability | GACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.12301208808823072 | [702,598] | [355,434] | 0 | hSpCas9 | negative selection | 5429639 | 2110318 | 2110340 | 16 | - | 27760321 | MOLM13 | viability | ATCGTCACGGCTGAGAACGAGG | PKD1 | ENSG00000008710 | -0.02769207254564665 | [641,517] | [557,115] | 0 | hSpCas9 | negative selection | 5429640 | 2110492 | 2110514 | 16 | - | 27760321 | MOLM13 | viability | GTCGTCAATGCAAGCCGCACGG | PKD1 | ENSG00000008710 | 1.028173829184569 | [729,727] | [1251,491] | 7 | hSpCas9 | negative selection | 5429641 | 2111438 | 2111460 | 16 | - | 27760321 | MOLM13 | viability | GACGGGCGACAACATCACGTGG | PKD1 | ENSG00000008710 | -0.9692607161403707 | [1472,1130] | [346,393] | -5 | hSpCas9 | negative selection | 5429642 | 2111540 | 2111562 | 16 | + | 27760321 | MOLM13 | viability | AAAGACGCGCACATCCGCCTGG | PKD1 | ENSG00000008710 | 1.1225912399661275 | [1008,789] | [591,1527] | 7 | hSpCas9 | negative selection | 5429643 | 2135557 | 2135580 | 16 | + | 27260156 | BXPC3 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.8585840970165246 | [172] | [75,135,90,94] | -9 | hSpCas9 | negative selection | 5562898 | 2135591 | 2135614 | 16 | + | 27260156 | BXPC3 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 0.40445343799754296 | [260] | [458,234,428,310] | 8 | hSpCas9 | negative selection | 5562899 | 2135557 | 2135580 | 16 | + | 27260156 | A673 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.43949362817677873 | [172] | [133,127,201,145] | -8 | hSpCas9 | negative selection | 5684149 | 2135591 | 2135614 | 16 | + | 27260156 | A673 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 0.23831778819229377 | [260] | [367,366,355,387] | 5 | hSpCas9 | negative selection | 5684150 | 2135557 | 2135580 | 16 | + | 27260156 | A375 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.7626100800958509 | [172] | [115,248,83,52] | -7 | hSpCas9 | negative selection | 5805400 | 2135591 | 2135614 | 16 | + | 27260156 | A375 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | -0.004426728745030806 | [260] | [259,301,459,203] | 0 | hSpCas9 | negative selection | 5805401 | 2135557 | 2135580 | 16 | + | 27260156 | COLO741 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.1104717014171741 | [172] | [224,234,158] | -2 | hSpCas9 | negative selection | 5926651 | 2135591 | 2135614 | 16 | + | 27260156 | COLO741 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 0.07079211420781073 | [260] | [403,363,290] | 1 | hSpCas9 | negative selection | 5926652 | 2135557 | 2135580 | 16 | + | 27260156 | CAL120 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.2273600662435098 | [172] | [460,99,34] | -3 | hSpCas9 | negative selection | 6047902 | 2135591 | 2135614 | 16 | + | 27260156 | CAL120 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | -0.3279098723314968 | [260] | [283,239,255] | -5 | hSpCas9 | negative selection | 6047903 | 2135557 | 2135580 | 16 | + | 27260156 | CADOES1 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -1.2350278673713562 | [172] | [101,38,70,60] | -9 | hSpCas9 | negative selection | 6169153 | 2135591 | 2135614 | 16 | + | 27260156 | CADOES1 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | -0.6329961440211851 | [260] | [178,117,171,156] | -8 | hSpCas9 | negative selection | 6169154 | 2135557 | 2135580 | 16 | + | 27260156 | EWS502 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.7037256794199345 | [172] | [110,159,49,126] | -8 | hSpCas9 | negative selection | 6290404 | 2135591 | 2135614 | 16 | + | 27260156 | EWS502 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 0.06799953235344502 | [260] | [273,276,269,342] | 1 | hSpCas9 | negative selection | 6290405 | 2135557 | 2135580 | 16 | + | 27260156 | EW8 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.5204393680129868 | [172] | [266,64,52,31] | -7 | hSpCas9 | negative selection | 6411655 | 2135591 | 2135614 | 16 | + | 27260156 | EW8 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | -0.03411284931135139 | [260] | [272,146,264,137] | 0 | hSpCas9 | negative selection | 6411656 | 2135557 | 2135580 | 16 | + | 27260156 | CORL105 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.11206587431021209 | [172] | [206,209,162,165] | -2 | hSpCas9 | negative selection | 6532906 | 2135591 | 2135614 | 16 | + | 27260156 | CORL105 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 0.3465218952285848 | [260] | [367,346,433,411] | 6 | hSpCas9 | negative selection | 6532907 | 2135557 | 2135580 | 16 | + | 27260156 | HS294T | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -1.1167328408044797 | [172] | [10,32,25,59] | -9 | hSpCas9 | negative selection | 6654157 | 2135591 | 2135614 | 16 | + | 27260156 | HS294T | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | -0.18010108340715147 | [260] | [94,90,76,92] | -3 | hSpCas9 | negative selection | 6654158 | 2135557 | 2135580 | 16 | + | 27260156 | HCC44 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.5079137506066838 | [172] | [162,169,152,65] | -6 | hSpCas9 | negative selection | 6775408 | 2135591 | 2135614 | 16 | + | 27260156 | HCC44 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 0.04219417056723562 | [260] | [380,188,364,311] | 0 | hSpCas9 | negative selection | 6775409 | 2135557 | 2135580 | 16 | + | 27260156 | G402 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -1.4975761262431035 | [172] | [46,85,36,122] | -9 | hSpCas9 | negative selection | 6896659 | 2135591 | 2135614 | 16 | + | 27260156 | G402 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 0.2436740142975472 | [260] | [581,479,221,263] | 3 | hSpCas9 | negative selection | 6896660 | 2135557 | 2135580 | 16 | + | 27260156 | L33 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.17144750616189186 | [172] | [107,80,104,142] | -4 | hSpCas9 | negative selection | 7017910 | 2135591 | 2135614 | 16 | + | 27260156 | L33 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 0.2110955502756089 | [260] | [244,151,185,297] | 4 | hSpCas9 | negative selection | 7017911 | 2135557 | 2135580 | 16 | + | 27260156 | K562 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.32153637360708376 | [172] | [159,162,96,80] | -4 | hSpCas9 | negative selection | 7139161 | 2135591 | 2135614 | 16 | + | 27260156 | K562 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 0.5377371099696113 | [260] | [311,402,283,344] | 7 | hSpCas9 | negative selection | 7139162 | 2135557 | 2135580 | 16 | + | 27260156 | HT29 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -1.0673615277479085 | [172] | [157,170,69,21] | -9 | hSpCas9 | negative selection | 7260412 | 2135591 | 2135614 | 16 | + | 27260156 | HT29 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | -0.2526459554434832 | [260] | [332,283,285,177] | -5 | hSpCas9 | negative selection | 7260413 | 2135557 | 2135580 | 16 | + | 27260156 | MHHES1 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.6143574831680425 | [172] | [116,106,171,110] | -8 | hSpCas9 | negative selection | 7381663 | 2135591 | 2135614 | 16 | + | 27260156 | MHHES1 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | -0.1554280034788016 | [260] | [180,231,415,218] | -3 | hSpCas9 | negative selection | 7381664 | 2135557 | 2135580 | 16 | + | 27260156 | MEWO | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | 0.3460269054148635 | [172] | [184,227,199] | 7 | hSpCas9 | negative selection | 7502914 | 2135591 | 2135614 | 16 | + | 27260156 | MEWO | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 0.05769285509333 | [260] | [276,213,275] | 1 | hSpCas9 | negative selection | 7502915 | 2135557 | 2135580 | 16 | + | 27260156 | LNCAPCLONEFGC | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.6613896551048812 | [172] | [76,128,73,110] | -7 | hSpCas9 | negative selection | 7624165 | 2135591 | 2135614 | 16 | + | 27260156 | LNCAPCLONEFGC | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | -0.07023101521264341 | [260] | [243,222,208,221] | -1 | hSpCas9 | negative selection | 7624166 | 2135557 | 2135580 | 16 | + | 27260156 | PANC0327 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.6879404776913938 | [172] | [62,48,169,102] | -7 | hSpCas9 | negative selection | 7745416 | 2135591 | 2135614 | 16 | + | 27260156 | PANC0327 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 0.0838067285227907 | [260] | [294,197,252,246] | 1 | hSpCas9 | negative selection | 7745417 | 2135557 | 2135580 | 16 | + | 27260156 | NCIH2009 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -1.291493224747681 | [172] | [138,99,64] | -8 | hSpCas9 | negative selection | 7866667 | 2135591 | 2135614 | 16 | + | 27260156 | NCIH2009 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 0.36171759683880406 | [260] | [656,366,419] | 5 | hSpCas9 | negative selection | 7866668 | 2135557 | 2135580 | 16 | + | 27260156 | NCIH1373 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -1.3862190998162527 | [172] | [57,74,73,22] | -8 | hSpCas9 | negative selection | 7987918 | 2135591 | 2135614 | 16 | + | 27260156 | NCIH1373 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | -0.0020427744593636277 | [260] | [336,376,247,51] | 0 | hSpCas9 | negative selection | 7987919 | 2135557 | 2135580 | 16 | + | 27260156 | PATU8902 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -1.22893721280384 | [172] | [63,120,159,43] | -8 | hSpCas9 | negative selection | 8109169 | 2135591 | 2135614 | 16 | + | 27260156 | PATU8902 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 0.24921140794702612 | [260] | [223,324,289,991] | 2 | hSpCas9 | negative selection | 8109170 | 2135557 | 2135580 | 16 | + | 27260156 | PANC1 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.999121225730752 | [172] | [79,65,91,58] | -8 | hSpCas9 | negative selection | 8230420 | 2135591 | 2135614 | 16 | + | 27260156 | PANC1 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 0.09296463631707597 | [260] | [234,160,275,260] | 1 | hSpCas9 | negative selection | 8230421 | 2135557 | 2135580 | 16 | + | 27260156 | PANC0813 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -1.1231633943889845 | [172] | [30,209,85,42] | -8 | hSpCas9 | negative selection | 8351671 | 2135591 | 2135614 | 16 | + | 27260156 | PANC0813 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 0.471140379616535 | [260] | [617,363,402,336] | 7 | hSpCas9 | negative selection | 8351672 | 2135557 | 2135580 | 16 | + | 27260156 | RDES | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.4140587886121976 | [172] | [139,145,122,190] | -6 | hSpCas9 | negative selection | 8472922 | 2135591 | 2135614 | 16 | + | 27260156 | RDES | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | -0.025732257970103145 | [260] | [207,333,327,320] | 0 | hSpCas9 | negative selection | 8472923 | 2135557 | 2135580 | 16 | + | 27260156 | PC3 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.5853021582441302 | [172] | [79,146,137,103] | -8 | hSpCas9 | negative selection | 8594173 | 2135591 | 2135614 | 16 | + | 27260156 | PC3 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 0.06841249885006273 | [260] | [134,218,506,367] | 1 | hSpCas9 | negative selection | 8594174 | 2135557 | 2135580 | 16 | + | 27260156 | PATU8988T | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.793299035563154 | [172] | [48,46,176,107] | -8 | hSpCas9 | negative selection | 8715424 | 2135591 | 2135614 | 16 | + | 27260156 | PATU8988T | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | -0.21286853377971782 | [260] | [208,298,122,250] | -4 | hSpCas9 | negative selection | 8715425 | 2135557 | 2135580 | 16 | + | 27260156 | T47D | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.6654614057129535 | [172] | [152,108,100,147] | -8 | hSpCas9 | negative selection | 8836675 | 2135591 | 2135614 | 16 | + | 27260156 | T47D | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 0.21434891706663317 | [260] | [363,271,363,419] | 4 | hSpCas9 | negative selection | 8836676 | 2135557 | 2135580 | 16 | + | 27260156 | SU8686 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.9992063193605332 | [172] | [55,54,73,179] | -8 | hSpCas9 | negative selection | 8957926 | 2135591 | 2135614 | 16 | + | 27260156 | SU8686 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | -0.05096274273232426 | [260] | [245,274,232,237] | -1 | hSpCas9 | negative selection | 8957927 | 2135557 | 2135580 | 16 | + | 27260156 | SKES1 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.24198626879798257 | [172] | [96,178,144,156] | -5 | hSpCas9 | negative selection | 9079177 | 2135591 | 2135614 | 16 | + | 27260156 | SKES1 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | -0.2960114348485534 | [260] | [235,254,138,223] | -6 | hSpCas9 | negative selection | 9079178 | 2135557 | 2135580 | 16 | + | 27260156 | TOV112D | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.41771445032979804 | [172] | [93,176,225,32] | -7 | hSpCas9 | negative selection | 9200428 | 2135591 | 2135614 | 16 | + | 27260156 | TOV112D | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | 0.05818183955494016 | [260] | [299,302,326,170] | 1 | hSpCas9 | negative selection | 9200429 | 2135557 | 2135580 | 16 | + | 27260156 | TC71 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.3430210387296284 | [172] | [82,101,99,312] | -7 | hSpCas9 | negative selection | 9321679 | 2135591 | 2135614 | 16 | + | 27260156 | TC71 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | -0.09894971724824964 | [260] | [236,298,276,229] | -3 | hSpCas9 | negative selection | 9321680 | 2135557 | 2135580 | 16 | + | 27260156 | TC32 | viability | CGCCGGGCGCTGGGCCGCAGAGG | PKD1 | ENSG00000008710 | -0.1705535656505004 | [172] | [124,134,174,144] | -3 | hSpCas9 | negative selection | 9442930 | 2135591 | 2135614 | 16 | + | 27260156 | TC32 | viability | GCAGGGCCCGCAGCCGCGCCCGG | PKD1 | ENSG00000008710 | -0.4055126123360915 | [260] | [176,78,312,227] | -6 | hSpCas9 | negative selection | 9442931 | 2097170 | 2097193 | 16 | - | 27869803 | HPAFII | viability after 27 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | 0.07380119522674744 | [899] | [707,322,NaN] | 0 | hSpCas9 | negative selection | 9556084 | 2097412 | 2097435 | 16 | - | 27869803 | HPAFII | viability after 27 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | 0.9583135819153112 | [113] | [170,70,NaN] | 7 | hSpCas9 | negative selection | 9556085 | 2109073 | 2109096 | 16 | - | 27869803 | HPAFII | viability after 27 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.6191381095896153 | [604] | [445,523,NaN] | 5 | hSpCas9 | negative selection | 9556086 | 2097170 | 2097193 | 16 | - | 27869803 | HPAFII | viability after 15 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | 0.04384505099937308 | [899] | [1564,643,NaN] | 0 | hSpCas9 | negative selection | 9638533 | 2097412 | 2097435 | 16 | - | 27869803 | HPAFII | viability after 15 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | 0.36423597070499003 | [113] | [227,113,NaN] | 4 | hSpCas9 | negative selection | 9638534 | 2109073 | 2109096 | 16 | - | 27869803 | HPAFII | viability after 15 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.4611804477791519 | [604] | [986,837,NaN] | 5 | hSpCas9 | negative selection | 9638535 | 2097170 | 2097193 | 16 | - | 27869803 | ASPC1 | viability after 36 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | 0.05553139059868606 | [2140] | [655,587,1002] | 0 | hSpCas9 | negative selection | 9720982 | 2097412 | 2097435 | 16 | - | 27869803 | ASPC1 | viability after 36 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | 2.360977759732175 | [186] | [227,434,327] | 9 | hSpCas9 | negative selection | 9720983 | 2109073 | 2109096 | 16 | - | 27869803 | ASPC1 | viability after 36 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | -0.49717744046308643 | [1536] | [474,303,369] | -5 | hSpCas9 | negative selection | 9720984 | 2097170 | 2097193 | 16 | - | 27869803 | PATU8988S | viability after 35 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | -0.21329686650703517 | [2034] | [686,726,NaN] | -2 | hSpCas9 | negative selection | 9803431 | 2097412 | 2097435 | 16 | - | 27869803 | PATU8988S | viability after 35 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | 0.9112951722765992 | [236] | [187,170,NaN] | 8 | hSpCas9 | negative selection | 9803432 | 2109073 | 2109096 | 16 | - | 27869803 | PATU8988S | viability after 35 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | -0.3517942699656711 | [1505] | [602,346,NaN] | -4 | hSpCas9 | negative selection | 9803433 | 2097170 | 2097193 | 16 | - | 27869803 | PATU8988S | viability after 31 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | -0.197391995851546 | [2034] | [514,952,NaN] | -2 | hSpCas9 | negative selection | 9885880 | 2097412 | 2097435 | 16 | - | 27869803 | PATU8988S | viability after 31 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | 0.8941598497402024 | [236] | [150,206,NaN] | 8 | hSpCas9 | negative selection | 9885881 | 2109073 | 2109096 | 16 | - | 27869803 | PATU8988S | viability after 31 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | -0.09247260769112065 | [1505] | [681,411,NaN] | -1 | hSpCas9 | negative selection | 9885882 | 2097170 | 2097193 | 16 | - | 27869803 | HPAFII | viability after 35 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | 0.471140414337335 | [899] | [743,504,NaN] | 3 | hSpCas9 | negative selection | 9968329 | 2097412 | 2097435 | 16 | - | 27869803 | HPAFII | viability after 35 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | 0.8120885186566271 | [113] | [169,23,NaN] | 5 | hSpCas9 | negative selection | 9968330 | 2109073 | 2109096 | 16 | - | 27869803 | HPAFII | viability after 35 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.5643874988833875 | [604] | [276,650,NaN] | 3 | hSpCas9 | negative selection | 9968331 | 2097170 | 2097193 | 16 | - | 27869803 | HPAFII | viability after 31 days | CCCTACCCAAGACACCCACATGG | PKD1 | ENSG00000008710 | -0.08879985606199536 | [899] | [629,305,NaN] | 0 | hSpCas9 | negative selection | 10050778 | 2097412 | 2097435 | 16 | - | 27869803 | HPAFII | viability after 31 days | GGGTAGCAATCTGCGGCAGCTGG | PKD1 | ENSG00000008710 | -0.1971409325821727 | [113] | [84,23,NaN] | -1 | hSpCas9 | negative selection | 10050779 | 2109073 | 2109096 | 16 | - | 27869803 | HPAFII | viability after 31 days | CGACGTCACCTACACGCCCGTGG | PKD1 | ENSG00000008710 | 0.6536038225770195 | [604] | [480,591,NaN] | 5 | hSpCas9 | negative selection | 10050780 | 2114286 | 2114309 | 16 | - | 28162770 | P31FUJ | viability | GGAGCACGTGGTGGACGTGGTGG | PKD1 | ENSG00000008710 | 0.9047013193355564 | [49] | [109] | 9 | hSpCas9 | negative selection | 10211801 | 2110358 | 2110381 | 16 | + | 28162770 | P31FUJ | viability | GGAGCGGAAGGTGTAAGAGATGG | PKD1 | ENSG00000008710 | -0.2246282729686786 | [175] | [176] | -2 | hSpCas9 | negative selection | 10211802 | 2090341 | 2090364 | 16 | - | 28162770 | P31FUJ | viability | GGAGCCCCAGGACTACGAGATGG | PKD1 | ENSG00000008710 | -0.023348838785429038 | [95] | [110] | 0 | hSpCas9 | negative selection | 10211803 | 2118248 | 2118271 | 16 | + | 28162770 | P31FUJ | viability | GCAGAGGGACAGGCAGGCAAAGG | PKD1 | ENSG00000008710 | -2.1790309479733976 | [157] | [40] | -8 | hSpCas9 | negative selection | 10211804 | 2115443 | 2115466 | 16 | - | 28162770 | P31FUJ | viability | GTCAGGGCCAGGGCTACCCGGGG | PKD1 | ENSG00000008710 | 0.41927449216531487 | [27] | [43] | 5 | hSpCas9 | negative selection | 10211805 | 2111765 | 2111788 | 16 | + | 28162770 | P31FUJ | viability | ACTCACACCCACAGCCACGGAGG | PKD1 | ENSG00000008710 | -0.02751902837928677 | [411] | [474] | 0 | hSpCas9 | negative selection | 10211806 | 2108886 | 2108909 | 16 | + | 28162770 | P31FUJ | viability | CAGTGGTAGGCCACACGCCGGGG | PKD1 | ENSG00000008710 | 0.8224802310868111 | [255] | [531] | 8 | hSpCas9 | negative selection | 10211807 | 2097467 | 2097490 | 16 | + | 28162770 | P31FUJ | viability | ACTGAGCGTTCCCTCGCCGGAGG | PKD1 | ENSG00000008710 | 0.12644751667871829 | [289] | [371] | 1 | hSpCas9 | negative selection | 10211808 | 2114286 | 2114309 | 16 | - | 28162770 | TF1 | viability | GGAGCACGTGGTGGACGTGGTGG | PKD1 | ENSG00000008710 | NaN | [NaN] | [0] | 1 | hSpCas9 | negative selection | 10381167 | 2110358 | 2110381 | 16 | + | 28162770 | TF1 | viability | GGAGCGGAAGGTGTAAGAGATGG | PKD1 | ENSG00000008710 | NaN | [NaN] | [58] | 1 | hSpCas9 | negative selection | 10381168 | 2090341 | 2090364 | 16 | - | 28162770 | TF1 | viability | GGAGCCCCAGGACTACGAGATGG | PKD1 | ENSG00000008710 | NaN | [NaN] | [33] | 1 | hSpCas9 | negative selection | 10381169 | 2118248 | 2118271 | 16 | + | 28162770 | TF1 | viability | GCAGAGGGACAGGCAGGCAAAGG | PKD1 | ENSG00000008710 | NaN | [NaN] | [4] | 1 | hSpCas9 | negative selection | 10381170 | 2115443 | 2115466 | 16 | - | 28162770 | TF1 | viability | GTCAGGGCCAGGGCTACCCGGGG | PKD1 | ENSG00000008710 | NaN | [NaN] | [6] | 1 | hSpCas9 | negative selection | 10381171 | 2111765 | 2111788 | 16 | + | 28162770 | TF1 | viability | ACTCACACCCACAGCCACGGAGG | PKD1 | ENSG00000008710 | NaN | [NaN] | [440] | 1 | hSpCas9 | negative selection | 10381172 | 2108886 | 2108909 | 16 | + | 28162770 | TF1 | viability | CAGTGGTAGGCCACACGCCGGGG | PKD1 | ENSG00000008710 | NaN | [NaN] | [208] | 1 | hSpCas9 | negative selection | 10381173 | 2097467 | 2097490 | 16 | + | 28162770 | TF1 | viability | ACTGAGCGTTCCCTCGCCGGAGG | PKD1 | ENSG00000008710 | NaN | [NaN] | [236] | 1 | hSpCas9 | negative selection | 10381174 | 2114286 | 2114309 | 16 | - | 28162770 | SKM1 | viability | GGAGCACGTGGTGGACGTGGTGG | PKD1 | ENSG00000008710 | 1.3678228608580119 | [15] | [72] | 9 | hSpCas9 | negative selection | 10550533 | 2110358 | 2110381 | 16 | + | 28162770 | SKM1 | viability | GGAGCGGAAGGTGTAAGAGATGG | PKD1 | ENSG00000008710 | -0.049412194125077885 | [47] | [81] | 0 | hSpCas9 | negative selection | 10550534 | 2090341 | 2090364 | 16 | - | 28162770 | SKM1 | viability | GGAGCCCCAGGACTACGAGATGG | PKD1 | ENSG00000008710 | -1.576889200185474 | [26] | [15] | -8 | hSpCas9 | negative selection | 10550535 | 2118248 | 2118271 | 16 | + | 28162770 | SKM1 | viability | GCAGAGGGACAGGCAGGCAAAGG | PKD1 | ENSG00000008710 | -1.2143191208007655 | [41] | [31] | -7 | hSpCas9 | negative selection | 10550536 | 2115443 | 2115466 | 16 | - | 28162770 | SKM1 | viability | GTCAGGGCCAGGGCTACCCGGGG | PKD1 | ENSG00000008710 | -1.3074285251922477 | [6] | [4] | -7 | hSpCas9 | negative selection | 10550537 | 2111765 | 2111788 | 16 | + | 28162770 | SKM1 | viability | ACTCACACCCACAGCCACGGAGG | PKD1 | ENSG00000008710 | 0.4613051028380495 | [105] | [257] | 4 | hSpCas9 | negative selection | 10550538 | 2108886 | 2108909 | 16 | + | 28162770 | SKM1 | viability | CAGTGGTAGGCCACACGCCGGGG | PKD1 | ENSG00000008710 | 0.14762465293447563 | [71] | [140] | 1 | hSpCas9 | negative selection | 10550539 | 2097467 | 2097490 | 16 | + | 28162770 | SKM1 | viability | ACTGAGCGTTCCCTCGCCGGAGG | PKD1 | ENSG00000008710 | -0.06195249074275824 | [61] | [104] | 0 | hSpCas9 | negative selection | 10550540 | 2114286 | 2114309 | 16 | - | 28162770 | SKM1 | viability | GGAGCACGTGGTGGACGTGGTGG | PKD1 | ENSG00000008710 | 1.3678228608580119 | [15] | [72] | 9 | hSpCas9 | negative selection | 10719899 | 2110358 | 2110381 | 16 | + | 28162770 | SKM1 | viability | GGAGCGGAAGGTGTAAGAGATGG | PKD1 | ENSG00000008710 | -0.049412194125077885 | [47] | [81] | 0 | hSpCas9 | negative selection | 10719900 | 2090341 | 2090364 | 16 | - | 28162770 | SKM1 | viability | GGAGCCCCAGGACTACGAGATGG | PKD1 | ENSG00000008710 | -1.576889200185474 | [26] | [15] | -8 | hSpCas9 | negative selection | 10719901 | 2118248 | 2118271 | 16 | + | 28162770 | SKM1 | viability | GCAGAGGGACAGGCAGGCAAAGG | PKD1 | ENSG00000008710 | -1.2143191208007655 | [41] | [31] | -7 | hSpCas9 | negative selection | 10719902 | 2115443 | 2115466 | 16 | - | 28162770 | SKM1 | viability | GTCAGGGCCAGGGCTACCCGGGG | PKD1 | ENSG00000008710 | -1.3074285251922477 | [6] | [4] | -7 | hSpCas9 | negative selection | 10719903 | 2111765 | 2111788 | 16 | + | 28162770 | SKM1 | viability | ACTCACACCCACAGCCACGGAGG | PKD1 | ENSG00000008710 | 0.4613051028380495 | [105] | [257] | 4 | hSpCas9 | negative selection | 10719904 | 2108886 | 2108909 | 16 | + | 28162770 | SKM1 | viability | CAGTGGTAGGCCACACGCCGGGG | PKD1 | ENSG00000008710 | 0.14762465293447563 | [71] | [140] | 1 | hSpCas9 | negative selection | 10719905 | 2097467 | 2097490 | 16 | + | 28162770 | SKM1 | viability | ACTGAGCGTTCCCTCGCCGGAGG | PKD1 | ENSG00000008710 | -0.06195249074275824 | [61] | [104] | 0 | hSpCas9 | negative selection | 10719906 | 2114286 | 2114309 | 16 | - | 28162770 | PL21 | viability | GGAGCACGTGGTGGACGTGGTGG | PKD1 | ENSG00000008710 | -1.3687032208685588 | [88] | [14] | -7 | hSpCas9 | negative selection | 10889265 | 2110358 | 2110381 | 16 | + | 28162770 | PL21 | viability | GGAGCGGAAGGTGTAAGAGATGG | PKD1 | ENSG00000008710 | 0.06889508121106758 | [137] | [62] | 0 | hSpCas9 | negative selection | 10889266 | 2090341 | 2090364 | 16 | - | 28162770 | PL21 | viability | GGAGCCCCAGGACTACGAGATGG | PKD1 | ENSG00000008710 | -0.3971012160102727 | [117] | [38] | -3 | hSpCas9 | negative selection | 10889267 | 2118248 | 2118271 | 16 | + | 28162770 | PL21 | viability | GCAGAGGGACAGGCAGGCAAAGG | PKD1 | ENSG00000008710 | -0.1313745292272402 | [150] | [59] | -1 | hSpCas9 | negative selection | 10889268 | 2115443 | 2115466 | 16 | - | 28162770 | PL21 | viability | GTCAGGGCCAGGGCTACCCGGGG | PKD1 | ENSG00000008710 | -1.6072153075682847 | [6] | [0] | -8 | hSpCas9 | negative selection | 10889269 | 2111765 | 2111788 | 16 | + | 28162770 | PL21 | viability | ACTCACACCCACAGCCACGGAGG | PKD1 | ENSG00000008710 | -0.5118796225466551 | [343] | [104] | -4 | hSpCas9 | negative selection | 10889270 | 2108886 | 2108909 | 16 | + | 28162770 | PL21 | viability | CAGTGGTAGGCCACACGCCGGGG | PKD1 | ENSG00000008710 | 0.37586690199816614 | [192] | [108] | 3 | hSpCas9 | negative selection | 10889271 | 2097467 | 2097490 | 16 | + | 28162770 | PL21 | viability | ACTGAGCGTTCCCTCGCCGGAGG | PKD1 | ENSG00000008710 | 0.6423132437056782 | [236] | [160] | 5 | hSpCas9 | negative selection | 10889272 | 2114286 | 2114309 | 16 | - | 28162770 | P31FUJ | viability | GGAGCACGTGGTGGACGTGGTGG | PKD1 | ENSG00000008710 | 0.9047013193355564 | [49] | [109] | 9 | hSpCas9 | negative selection | 11058631 | 2110358 | 2110381 | 16 | + | 28162770 | P31FUJ | viability | GGAGCGGAAGGTGTAAGAGATGG | PKD1 | ENSG00000008710 | -0.2246282729686786 | [175] | [176] | -2 | hSpCas9 | negative selection | 11058632 | 2090341 | 2090364 | 16 | - | 28162770 | P31FUJ | viability | GGAGCCCCAGGACTACGAGATGG | PKD1 | ENSG00000008710 | -0.023348838785429038 | [95] | [110] | 0 | hSpCas9 | negative selection | 11058633 | 2118248 | 2118271 | 16 | + | 28162770 | P31FUJ | viability | GCAGAGGGACAGGCAGGCAAAGG | PKD1 | ENSG00000008710 | -2.1790309479733976 | [157] | [40] | -8 | hSpCas9 | negative selection | 11058634 | 2115443 | 2115466 | 16 | - | 28162770 | P31FUJ | viability | GTCAGGGCCAGGGCTACCCGGGG | PKD1 | ENSG00000008710 | 0.41927449216531487 | [27] | [43] | 5 | hSpCas9 | negative selection | 11058635 | 2111765 | 2111788 | 16 | + | 28162770 | P31FUJ | viability | ACTCACACCCACAGCCACGGAGG | PKD1 | ENSG00000008710 | -0.02751902837928677 | [411] | [474] | 0 | hSpCas9 | negative selection | 11058636 | 2108886 | 2108909 | 16 | + | 28162770 | P31FUJ | viability | CAGTGGTAGGCCACACGCCGGGG | PKD1 | ENSG00000008710 | 0.8224802310868111 | [255] | [531] | 8 | hSpCas9 | negative selection | 11058637 | 2097467 | 2097490 | 16 | + | 28162770 | P31FUJ | viability | ACTGAGCGTTCCCTCGCCGGAGG | PKD1 | ENSG00000008710 | 0.12644751667871829 | [289] | [371] | 1 | hSpCas9 | negative selection | 11058638 | 2114286 | 2114309 | 16 | - | 28162770 | OCIAML5 | viability | GGAGCACGTGGTGGACGTGGTGG | PKD1 | ENSG00000008710 | -0.19214201246161866 | [49] | [78] | -1 | hSpCas9 | negative selection | 11227997 | 2110358 | 2110381 | 16 | + | 28162770 | OCIAML5 | viability | GGAGCGGAAGGTGTAAGAGATGG | PKD1 | ENSG00000008710 | -0.002206920291857317 | [85] | [154] | 0 | hSpCas9 | negative selection | 11227998 | 2090341 | 2090364 | 16 | - | 28162770 | OCIAML5 | viability | GGAGCCCCAGGACTACGAGATGG | PKD1 | ENSG00000008710 | -1.2671040701428409 | [67] | [50] | -6 | hSpCas9 | negative selection | 11227999 | 2118248 | 2118271 | 16 | + | 28162770 | OCIAML5 | viability | GCAGAGGGACAGGCAGGCAAAGG | PKD1 | ENSG00000008710 | -3.1350005341354956 | [72] | [14] | -9 | hSpCas9 | negative selection | 11228000 | 2115443 | 2115466 | 16 | - | 28162770 | OCIAML5 | viability | GTCAGGGCCAGGGCTACCCGGGG | PKD1 | ENSG00000008710 | 0.9552883511936074 | [9] | [34] | 8 | hSpCas9 | negative selection | 11228001 | 2111765 | 2111788 | 16 | + | 28162770 | OCIAML5 | viability | ACTCACACCCACAGCCACGGAGG | PKD1 | ENSG00000008710 | 0.5315651240485411 | [237] | [620] | 4 | hSpCas9 | negative selection | 11228002 | 2108886 | 2108909 | 16 | + | 28162770 | OCIAML5 | viability | CAGTGGTAGGCCACACGCCGGGG | PKD1 | ENSG00000008710 | -0.5261912914599719 | [145] | [182] | -4 | hSpCas9 | negative selection | 11228003 | 2097467 | 2097490 | 16 | + | 28162770 | OCIAML5 | viability | ACTGAGCGTTCCCTCGCCGGAGG | PKD1 | ENSG00000008710 | -0.4828327611982779 | [167] | [216] | -3 | hSpCas9 | negative selection | 11228004 | 2114286 | 2114309 | 16 | - | 28162770 | EOL1 | viability | GGAGCACGTGGTGGACGTGGTGG | PKD1 | ENSG00000008710 | -0.8530598070930175 | [119] | [34] | -5 | hSpCas9 | negative selection | 11397363 | 2110358 | 2110381 | 16 | + | 28162770 | EOL1 | viability | GGAGCGGAAGGTGTAAGAGATGG | PKD1 | ENSG00000008710 | 0.4188485493740317 | [300] | [211] | 4 | hSpCas9 | negative selection | 11397364 | 2090341 | 2090364 | 16 | - | 28162770 | EOL1 | viability | GGAGCCCCAGGACTACGAGATGG | PKD1 | ENSG00000008710 | -0.8448393002880488 | [224] | [65] | -5 | hSpCas9 | negative selection | 11397365 | 2118248 | 2118271 | 16 | + | 28162770 | EOL1 | viability | GCAGAGGGACAGGCAGGCAAAGG | PKD1 | ENSG00000008710 | -0.08676754165729947 | [255] | [126] | 0 | hSpCas9 | negative selection | 11397366 | 2115443 | 2115466 | 16 | - | 28162770 | EOL1 | viability | GTCAGGGCCAGGGCTACCCGGGG | PKD1 | ENSG00000008710 | -0.2978446497659135 | [6] | [2] | -2 | hSpCas9 | negative selection | 11397367 | 2111765 | 2111788 | 16 | + | 28162770 | EOL1 | viability | ACTCACACCCACAGCCACGGAGG | PKD1 | ENSG00000008710 | 0.3209325639474866 | [505] | [332] | 3 | hSpCas9 | negative selection | 11397368 | 2108886 | 2108909 | 16 | + | 28162770 | EOL1 | viability | CAGTGGTAGGCCACACGCCGGGG | PKD1 | ENSG00000008710 | 1.3330126169258922 | [219] | [291] | 9 | hSpCas9 | negative selection | 11397369 | 2097467 | 2097490 | 16 | + | 28162770 | EOL1 | viability | ACTGAGCGTTCCCTCGCCGGAGG | PKD1 | ENSG00000008710 | 0.29477142349867824 | [375] | [242] | 2 | hSpCas9 | negative selection | 11397370 | 2114286 | 2114309 | 16 | - | 28162770 | MOLM13 | viability | GGAGCACGTGGTGGACGTGGTGG | PKD1 | ENSG00000008710 | -4.941501554593123 | [84] | [1] | -9 | hSpCas9 | negative selection | 11566729 | 2110358 | 2110381 | 16 | + | 28162770 | MOLM13 | viability | GGAGCGGAAGGTGTAAGAGATGG | PKD1 | ENSG00000008710 | -0.9365008735347564 | [224] | [84] | -5 | hSpCas9 | negative selection | 11566730 | 2090341 | 2090364 | 16 | - | 28162770 | MOLM13 | viability | GGAGCCCCAGGACTACGAGATGG | PKD1 | ENSG00000008710 | 1.125783404719586 | [134] | [212] | 8 | hSpCas9 | negative selection | 11566731 | 2118248 | 2118271 | 16 | + | 28162770 | MOLM13 | viability | GCAGAGGGACAGGCAGGCAAAGG | PKD1 | ENSG00000008710 | -1.9266424622996239 | [162] | [30] | -7 | hSpCas9 | negative selection | 11566732 | 2115443 | 2115466 | 16 | - | 28162770 | MOLM13 | viability | GTCAGGGCCAGGGCTACCCGGGG | PKD1 | ENSG00000008710 | 3.052851882265735 | [2] | [17] | 9 | hSpCas9 | negative selection | 11566733 | 2111765 | 2111788 | 16 | + | 28162770 | MOLM13 | viability | ACTCACACCCACAGCCACGGAGG | PKD1 | ENSG00000008710 | -0.1406126759832098 | [586] | [384] | -1 | hSpCas9 | negative selection | 11566734 | 2108886 | 2108909 | 16 | + | 28162770 | MOLM13 | viability | CAGTGGTAGGCCACACGCCGGGG | PKD1 | ENSG00000008710 | 0.3811280696252953 | [256] | [241] | 2 | hSpCas9 | negative selection | 11566735 | 2097467 | 2097490 | 16 | + | 28162770 | MOLM13 | viability | ACTGAGCGTTCCCTCGCCGGAGG | PKD1 | ENSG00000008710 | -0.708433391095884 | [338] | [149] | -4 | hSpCas9 | negative selection | 11566736 | 2114286 | 2114309 | 16 | - | 28162770 | HEL | viability | GGAGCACGTGGTGGACGTGGTGG | PKD1 | ENSG00000008710 | 0.2935892683779703 | [106] | [83] | 2 | hSpCas9 | negative selection | 11736095 | 2110358 | 2110381 | 16 | + | 28162770 | HEL | viability | GGAGCGGAAGGTGTAAGAGATGG | PKD1 | ENSG00000008710 | -0.006504420053062038 | [217] | [138] | 0 | hSpCas9 | negative selection | 11736096 | 2090341 | 2090364 | 16 | - | 28162770 | HEL | viability | GGAGCCCCAGGACTACGAGATGG | PKD1 | ENSG00000008710 | -0.9339084005087954 | [172] | [57] | -5 | hSpCas9 | negative selection | 11736097 | 2118248 | 2118271 | 16 | + | 28162770 | HEL | viability | GCAGAGGGACAGGCAGGCAAAGG | PKD1 | ENSG00000008710 | -6.595665907324722 | [150] | [0] | -9 | hSpCas9 | negative selection | 11736098 | 2115443 | 2115466 | 16 | - | 28162770 | HEL | viability | GTCAGGGCCAGGGCTACCCGGGG | PKD1 | ENSG00000008710 | 1.029761955109604 | [12] | [16] | 8 | hSpCas9 | negative selection | 11736099 | 2111765 | 2111788 | 16 | + | 28162770 | HEL | viability | ACTCACACCCACAGCCACGGAGG | PKD1 | ENSG00000008710 | 0.22561801822102423 | [461] | [345] | 1 | hSpCas9 | negative selection | 11736100 | 2108886 | 2108909 | 16 | + | 28162770 | HEL | viability | CAGTGGTAGGCCACACGCCGGGG | PKD1 | ENSG00000008710 | -0.13590479341571976 | [198] | [115] | -1 | hSpCas9 | negative selection | 11736101 | 2097467 | 2097490 | 16 | + | 28162770 | HEL | viability | ACTGAGCGTTCCCTCGCCGGAGG | PKD1 | ENSG00000008710 | 0.06046541880684078 | [267] | [178] | 0 | hSpCas9 | negative selection | 11736102 | 2114286 | 2114309 | 16 | - | 28162770 | MV411 | viability | GGAGCACGTGGTGGACGTGGTGG | PKD1 | ENSG00000008710 | -0.39146375704918457 | [108] | [69] | -3 | hSpCas9 | negative selection | 11905461 | 2110358 | 2110381 | 16 | + | 28162770 | MV411 | viability | GGAGCGGAAGGTGTAAGAGATGG | PKD1 | ENSG00000008710 | -0.23798927638746634 | [181] | [129] | -2 | hSpCas9 | negative selection | 11905462 | 2090341 | 2090364 | 16 | - | 28162770 | MV411 | viability | GGAGCCCCAGGACTACGAGATGG | PKD1 | ENSG00000008710 | -1.6594530448257432 | [119] | [31] | -7 | hSpCas9 | negative selection | 11905463 | 2118248 | 2118271 | 16 | + | 28162770 | MV411 | viability | GCAGAGGGACAGGCAGGCAAAGG | PKD1 | ENSG00000008710 | -0.9489596620207279 | [109] | [47] | -6 | hSpCas9 | negative selection | 11905464 | 2115443 | 2115466 | 16 | - | 28162770 | MV411 | viability | GTCAGGGCCAGGGCTACCCGGGG | PKD1 | ENSG00000008710 | 1.9844031449489816 | [5] | [19] | 9 | hSpCas9 | negative selection | 11905465 | 2111765 | 2111788 | 16 | + | 28162770 | MV411 | viability | ACTCACACCCACAGCCACGGAGG | PKD1 | ENSG00000008710 | 0.31067998477459424 | [423] | [442] | 2 | hSpCas9 | negative selection | 11905466 | 2108886 | 2108909 | 16 | + | 28162770 | MV411 | viability | CAGTGGTAGGCCACACGCCGGGG | PKD1 | ENSG00000008710 | 0.4509709448679074 | [164] | [189] | 4 | hSpCas9 | negative selection | 11905467 | 2097467 | 2097490 | 16 | + | 28162770 | MV411 | viability | ACTGAGCGTTCCCTCGCCGGAGG | PKD1 | ENSG00000008710 | -0.32529864760512156 | [234] | [157] | -2 | hSpCas9 | negative selection | 11905468 | 2114286 | 2114309 | 16 | - | 28162770 | MONOMAC1 | viability | GGAGCACGTGGTGGACGTGGTGG | PKD1 | ENSG00000008710 | -0.35231507253746464 | [48] | [43] | -3 | hSpCas9 | negative selection | 12074827 | 2110358 | 2110381 | 16 | + | 28162770 | MONOMAC1 | viability | GGAGCGGAAGGTGTAAGAGATGG | PKD1 | ENSG00000008710 | -0.8368612828152281 | [133] | [85] | -6 | hSpCas9 | negative selection | 12074828 | 2090341 | 2090364 | 16 | - | 28162770 | MONOMAC1 | viability | GGAGCCCCAGGACTACGAGATGG | PKD1 | ENSG00000008710 | -0.7029277767895111 | [70] | [49] | -5 | hSpCas9 | negative selection | 12074829 | 2118248 | 2118271 | 16 | + | 28162770 | MONOMAC1 | viability | GCAGAGGGACAGGCAGGCAAAGG | PKD1 | ENSG00000008710 | -1.1690224708899573 | [101] | [51] | -7 | hSpCas9 | negative selection | 12074830 | 2115443 | 2115466 | 16 | - | 28162770 | MONOMAC1 | viability | GTCAGGGCCAGGGCTACCCGGGG | PKD1 | ENSG00000008710 | -2.071505964975695 | [10] | [2] | -9 | hSpCas9 | negative selection | 12074831 | 2111765 | 2111788 | 16 | + | 28162770 | MONOMAC1 | viability | ACTCACACCCACAGCCACGGAGG | PKD1 | ENSG00000008710 | -0.0181628888897587 | [249] | [282] | 0 | hSpCas9 | negative selection | 12074832 | 2108886 | 2108909 | 16 | + | 28162770 | MONOMAC1 | viability | CAGTGGTAGGCCACACGCCGGGG | PKD1 | ENSG00000008710 | -0.04503375361450364 | [116] | [129] | 0 | hSpCas9 | negative selection | 12074833 | 2097467 | 2097490 | 16 | + | 28162770 | MONOMAC1 | viability | ACTGAGCGTTCCCTCGCCGGAGG | PKD1 | ENSG00000008710 | 0.7289625714966694 | [139] | [265] | 7 | hSpCas9 | negative selection | 12074834 | 2114286 | 2114309 | 16 | - | 28162770 | OCIAML2 | viability | GGAGCACGTGGTGGACGTGGTGG | PKD1 | ENSG00000008710 | 1.211194214731584 | [5] | [76] | 9 | hSpCas9 | negative selection | 12244193 | 2110358 | 2110381 | 16 | + | 28162770 | OCIAML2 | viability | GGAGCGGAAGGTGTAAGAGATGG | PKD1 | ENSG00000008710 | -1.503051302934539 | [44] | [87] | -7 | hSpCas9 | negative selection | 12244194 | 2090341 | 2090364 | 16 | - | 28162770 | OCIAML2 | viability | GGAGCCCCAGGACTACGAGATGG | PKD1 | ENSG00000008710 | -2.236164571605138 | [16] | [19] | -8 | hSpCas9 | negative selection | 12244195 | 2118248 | 2118271 | 16 | + | 28162770 | OCIAML2 | viability | GCAGAGGGACAGGCAGGCAAAGG | PKD1 | ENSG00000008710 | -1.2742326124386578 | [23] | [54] | -7 | hSpCas9 | negative selection | 12244196 | 2115443 | 2115466 | 16 | - | 28162770 | OCIAML2 | viability | GTCAGGGCCAGGGCTACCCGGGG | PKD1 | ENSG00000008710 | -1.2482374039057138 | [2] | [6] | -7 | hSpCas9 | negative selection | 12244197 | 2111765 | 2111788 | 16 | + | 28162770 | OCIAML2 | viability | ACTCACACCCACAGCCACGGAGG | PKD1 | ENSG00000008710 | 0.18758165750963351 | [47] | [302] | 1 | hSpCas9 | negative selection | 12244198 | 2108886 | 2108909 | 16 | + | 28162770 | OCIAML2 | viability | CAGTGGTAGGCCACACGCCGGGG | PKD1 | ENSG00000008710 | 0.8964870434114567 | [21] | [226] | 8 | hSpCas9 | negative selection | 12244199 | 2097467 | 2097490 | 16 | + | 28162770 | OCIAML2 | viability | ACTGAGCGTTCCCTCGCCGGAGG | PKD1 | ENSG00000008710 | 0.10799114860516847 | [37] | [226] | 1 | hSpCas9 | negative selection | 12244200 | 2114286 | 2114309 | 16 | - | 28162770 | OCIAML3 | viability | GGAGCACGTGGTGGACGTGGTGG | PKD1 | ENSG00000008710 | 0.44161626940655807 | [19] | [81] | 4 | hSpCas9 | negative selection | 12413559 | 2110358 | 2110381 | 16 | + | 28162770 | OCIAML3 | viability | GGAGCGGAAGGTGTAAGAGATGG | PKD1 | ENSG00000008710 | -0.18738238086151943 | [42] | [113] | -1 | hSpCas9 | negative selection | 12413560 | 2090341 | 2090364 | 16 | - | 28162770 | OCIAML3 | viability | GGAGCCCCAGGACTACGAGATGG | PKD1 | ENSG00000008710 | 2.1208351429439025 | [22] | [301] | 9 | hSpCas9 | negative selection | 12413561 | 2118248 | 2118271 | 16 | + | 28162770 | OCIAML3 | viability | GCAGAGGGACAGGCAGGCAAAGG | PKD1 | ENSG00000008710 | 0.3279898476745638 | [56] | [215] | 3 | hSpCas9 | negative selection | 12413562 | 2115443 | 2115466 | 16 | - | 28162770 | OCIAML3 | viability | GTCAGGGCCAGGGCTACCCGGGG | PKD1 | ENSG00000008710 | -2.5940076403241634 | [3] | [1] | -9 | hSpCas9 | negative selection | 12413563 | 2111765 | 2111788 | 16 | + | 28162770 | OCIAML3 | viability | ACTCACACCCACAGCCACGGAGG | PKD1 | ENSG00000008710 | -0.22596762058248887 | [116] | [301] | -2 | hSpCas9 | negative selection | 12413564 | 2108886 | 2108909 | 16 | + | 28162770 | OCIAML3 | viability | CAGTGGTAGGCCACACGCCGGGG | PKD1 | ENSG00000008710 | 0.48476947305995377 | [48] | [206] | 4 | hSpCas9 | negative selection | 12413565 | 2097467 | 2097490 | 16 | + | 28162770 | OCIAML3 | viability | ACTGAGCGTTCCCTCGCCGGAGG | PKD1 | ENSG00000008710 | 0.22911459759175742 | [51] | [183] | 2 | hSpCas9 | negative selection | 12413566 |