Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:5347
• Symbol:PLK1
• Description:polo like kinase 1

DataSource: http://genomecrispr.dkfz.de/#!/results/PLK1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
23679063	23679086	16	+	26472758	Jiyoye	viability	TAGTGGACCCACGCAGCCGGCGG	PLK1	ENSG00000166851	-3.708301835914063	[51]	[2]	-9	hSpCas9	negative selection	122431
23683995	23684018	16	-	26472758	Jiyoye	viability	GAATGGTCAGGCAGGTGATGGGG	PLK1	ENSG00000166851	-2.0739513082307433	[267]	[47]	-8	hSpCas9	negative selection	122432
23679196	23679219	16	+	26472758	Jiyoye	viability	GCTGCTCAAGCCGCACCAGAGGG	PLK1	ENSG00000166851	-2.694362644956189	[102]	[11]	-9	hSpCas9	negative selection	122433
23681011	23681034	16	+	26472758	Jiyoye	viability	GAAAGGGCACAGTTTCGAGGTGG	PLK1	ENSG00000166851	-2.5746772717838673	[78]	[9]	-9	hSpCas9	negative selection	122434
23679259	23679282	16	-	26472758	Jiyoye	viability	GGAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-2.8116592204173854	[269]	[28]	-9	hSpCas9	negative selection	122435
23679331	23679354	16	-	26472758	Jiyoye	viability	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-6.162680226825074	[94]	[0]	-9	hSpCas9	negative selection	122436
23680930	23680953	16	+	26472758	Jiyoye	viability	AACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-1.4469737520306718	[46]	[12]	-7	hSpCas9	negative selection	122437
23683863	23683886	16	+	26472758	Jiyoye	viability	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	-5.923741496608744	[160]	[1]	-9	hSpCas9	negative selection	122438
23683929	23683952	16	-	26472758	Jiyoye	viability	GCAGCTCGTTAATGGTTGGGCGG	PLK1	ENSG00000166851	-1.8791288036507678	[199]	[40]	-8	hSpCas9	negative selection	122439
23679063	23679086	16	+	26472758	KBM7	viability	TAGTGGACCCACGCAGCCGGCGG	PLK1	ENSG00000166851	-3.721886377842856	[202,132]	[7,3]	-9	hSpCas9	negative selection	313549
23683995	23684018	16	-	26472758	KBM7	viability	GAATGGTCAGGCAGGTGATGGGG	PLK1	ENSG00000166851	-2.6294918867477635	[1439,1375]	[92,119]	-9	hSpCas9	negative selection	313550
23679196	23679219	16	+	26472758	KBM7	viability	GCTGCTCAAGCCGCACCAGAGGG	PLK1	ENSG00000166851	-0.899234869626067	[543,331]	[103,111]	-6	hSpCas9	negative selection	313551
23681011	23681034	16	+	26472758	KBM7	viability	GAAAGGGCACAGTTTCGAGGTGG	PLK1	ENSG00000166851	-1.7200418347057667	[400,189]	[24,54]	-8	hSpCas9	negative selection	313552
23679259	23679282	16	-	26472758	KBM7	viability	GGAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-1.7280177996015675	[696,376]	[106,44]	-8	hSpCas9	negative selection	313553
23679331	23679354	16	-	26472758	KBM7	viability	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-4.159690155997369	[342,177]	[12,0]	-9	hSpCas9	negative selection	313554
23680930	23680953	16	+	26472758	KBM7	viability	AACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-2.0822770823082384	[420,308]	[28,49]	-8	hSpCas9	negative selection	313555
23683863	23683886	16	+	26472758	KBM7	viability	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	-3.1148793488759137	[629,395]	[39,15]	-9	hSpCas9	negative selection	313556
23683929	23683952	16	-	26472758	KBM7	viability	GCAGCTCGTTAATGGTTGGGCGG	PLK1	ENSG00000166851	-1.8741120450961755	[1131,1100]	[205,87]	-8	hSpCas9	negative selection	313557
23679063	23679086	16	+	26472758	Raji	viability	TAGTGGACCCACGCAGCCGGCGG	PLK1	ENSG00000166851	-3.9906485475869276	[136]	[1]	-9	hSpCas9	negative selection	504667
23683995	23684018	16	-	26472758	Raji	viability	GAATGGTCAGGCAGGTGATGGGG	PLK1	ENSG00000166851	-2.8213815598576817	[730]	[23]	-9	hSpCas9	negative selection	504668
23679196	23679219	16	+	26472758	Raji	viability	GCTGCTCAAGCCGCACCAGAGGG	PLK1	ENSG00000166851	-0.8233538021892868	[182]	[23]	-6	hSpCas9	negative selection	504669
23681011	23681034	16	+	26472758	Raji	viability	GAAAGGGCACAGTTTCGAGGTGG	PLK1	ENSG00000166851	-2.8154486041039406	[181]	[5]	-9	hSpCas9	negative selection	504670
23679259	23679282	16	-	26472758	Raji	viability	GGAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-1.8638574716449765	[297]	[18]	-8	hSpCas9	negative selection	504671
23679331	23679354	16	-	26472758	Raji	viability	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-2.526822484367406	[148]	[5]	-9	hSpCas9	negative selection	504672
23680930	23680953	16	+	26472758	Raji	viability	AACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-1.6367775601968106	[200]	[14]	-8	hSpCas9	negative selection	504673
23683863	23683886	16	+	26472758	Raji	viability	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	-3.062541466068713	[287]	[7]	-9	hSpCas9	negative selection	504674
23683929	23683952	16	-	26472758	Raji	viability	GCAGCTCGTTAATGGTTGGGCGG	PLK1	ENSG00000166851	-2.8865926769986308	[477]	[14]	-9	hSpCas9	negative selection	504675
23679063	23679086	16	+	26472758	K562	viability	TAGTGGACCCACGCAGCCGGCGG	PLK1	ENSG00000166851	-2.443637266018813	[173]	[26]	-8	hSpCas9	negative selection	695785
23683995	23684018	16	-	26472758	K562	viability	GAATGGTCAGGCAGGTGATGGGG	PLK1	ENSG00000166851	-3.5273972131873417	[1242]	[90]	-8	hSpCas9	negative selection	695786
23679196	23679219	16	+	26472758	K562	viability	GCTGCTCAAGCCGCACCAGAGGG	PLK1	ENSG00000166851	-2.0417382361990937	[238]	[48]	-7	hSpCas9	negative selection	695787
23681011	23681034	16	+	26472758	K562	viability	GAAAGGGCACAGTTTCGAGGTGG	PLK1	ENSG00000166851	-1.0750826298263754	[296]	[118]	-5	hSpCas9	negative selection	695788
23679259	23679282	16	-	26472758	K562	viability	GGAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-3.015704082747444	[593]	[61]	-8	hSpCas9	negative selection	695789
23679331	23679354	16	-	26472758	K562	viability	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-5.638224321695395	[235]	[3]	-9	hSpCas9	negative selection	695790
23680930	23680953	16	+	26472758	K562	viability	AACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-1.7031138524394174	[269]	[69]	-7	hSpCas9	negative selection	695791
23683863	23683886	16	+	26472758	K562	viability	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	-3.7874301383728923	[228]	[13]	-9	hSpCas9	negative selection	695792
23683929	23683952	16	-	26472758	K562	viability	GCAGCTCGTTAATGGTTGGGCGG	PLK1	ENSG00000166851	-3.03903521940628	[739]	[75]	-8	hSpCas9	negative selection	695793
23679195	23679218	16	+	26627737	DLD1	viability	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	-1.6716520209403432	[461]	[2,83,49]	-8	hSpCas9	negative selection	793250
23679331	23679354	16	-	26627737	DLD1	viability	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-5.230055808507948	[428]	[8,0,0]	-9	hSpCas9	negative selection	793251
23680978	23681001	16	+	26627737	DLD1	viability	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-3.336967053062714	[457]	[0,3,33]	-9	hSpCas9	negative selection	793252
23684028	23684051	16	+	26627737	DLD1	viability	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	0.5767729710959669	[801]	[414,453,271]	6	hSpCas9	negative selection	793253
23689242	23689265	16	+	26627737	DLD1	viability	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-4.848473817658047	[684]	[20,0,0]	-9	hSpCas9	negative selection	793255
23679195	23679218	16	+	26627737	GBM cells	viability after 5 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	0.43325030253687363	[173]	[99,151]	6	hSpCas9	negative selection	875565
23679331	23679354	16	-	26627737	GBM cells	viability after 5 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-1.7065127283951864	[212]	[42,26]	-9	hSpCas9	negative selection	875566
23680978	23681001	16	+	26627737	GBM cells	viability after 5 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-3.5242975558388587	[353]	[15,16]	-9	hSpCas9	negative selection	875567
23684028	23684051	16	+	26627737	GBM cells	viability after 5 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	0.42802314087332455	[315]	[217,237]	6	hSpCas9	negative selection	875568
23689242	23689265	16	+	26627737	GBM cells	viability after 5 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-3.9606710059444765	[449]	[6,23]	-9	hSpCas9	negative selection	875570
23679195	23679218	16	+	26627737	GBM cells	viability after 13 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	0.4938038437819299	[173]	[154,114]	6	hSpCas9	negative selection	957880
23679331	23679354	16	-	26627737	GBM cells	viability after 13 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-1.5783996584049564	[212]	[57,22]	-9	hSpCas9	negative selection	957881
23680978	23681001	16	+	26627737	GBM cells	viability after 13 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-2.0363406472112406	[353]	[37,53]	-9	hSpCas9	negative selection	957882
23684028	23684051	16	+	26627737	GBM cells	viability after 13 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	0.6851931810965917	[315]	[337,224]	8	hSpCas9	negative selection	957883
23689242	23689265	16	+	26627737	GBM cells	viability after 13 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-3.8324076197600627	[449]	[20,13]	-9	hSpCas9	negative selection	957885
23679195	23679218	16	+	26627737	GBM cells	viability after 21 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	0.6689910027959322	[173]	[154,145]	6	hSpCas9	negative selection	1040195
23679331	23679354	16	-	26627737	GBM cells	viability after 21 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-1.8430005603131927	[212]	[37,26]	-8	hSpCas9	negative selection	1040196
23680978	23681001	16	+	26627737	GBM cells	viability after 21 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-1.4569446915814315	[353]	[56,81]	-8	hSpCas9	negative selection	1040197
23684028	23684051	16	+	26627737	GBM cells	viability after 21 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	1.0487146585062748	[315]	[386,325]	9	hSpCas9	negative selection	1040198
23689242	23689265	16	+	26627737	GBM cells	viability after 21 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-3.4946636503681674	[449]	[28,14]	-9	hSpCas9	negative selection	1040200
23679195	23679218	16	+	26627737	RPE1	viability after 9 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	1.1192239250347176	[146]	[85,117]	6	hSpCas9	negative selection	1122510
23679331	23679354	16	-	26627737	RPE1	viability after 9 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-2.230768859283827	[1383]	[28,173]	-9	hSpCas9	negative selection	1122511
23680978	23681001	16	+	26627737	RPE1	viability after 9 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-5.918864040771878	[361]	[0,2]	-9	hSpCas9	negative selection	1122512
23684028	23684051	16	+	26627737	RPE1	viability after 9 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	1.0001057498376447	[720]	[440,464]	6	hSpCas9	negative selection	1122513
23689242	23689265	16	+	26627737	RPE1	viability after 9 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-2.129956287954573	[1008]	[93,43]	-9	hSpCas9	negative selection	1122515
23679195	23679218	16	+	26627737	RPE1	viability after 12 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	1.91616076791955	[146]	[150,146]	8	hSpCas9	negative selection	1204825
23679331	23679354	16	-	26627737	RPE1	viability after 12 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-3.449842135044439	[1383]	[0,68]	-9	hSpCas9	negative selection	1204826
23680978	23681001	16	+	26627737	RPE1	viability after 12 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-4.767233207692947	[361]	[5,0]	-9	hSpCas9	negative selection	1204827
23684028	23684051	16	+	26627737	RPE1	viability after 12 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	1.2350555793389122	[720]	[437,474]	7	hSpCas9	negative selection	1204828
23689242	23689265	16	+	26627737	RPE1	viability after 12 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-1.6587327887796381	[1008]	[97,72]	-8	hSpCas9	negative selection	1204830
23679195	23679218	16	+	26627737	RPE1	viability after 15 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	1.785936771357047	[146]	[92,191]	8	hSpCas9	negative selection	1287140
23679331	23679354	16	-	26627737	RPE1	viability after 15 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-5.010612956956078	[1383]	[3,19]	-9	hSpCas9	negative selection	1287141
23680978	23681001	16	+	26627737	RPE1	viability after 15 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-6.678097013211311	[361]	[0,0]	-9	hSpCas9	negative selection	1287142
23684028	23684051	16	+	26627737	RPE1	viability after 15 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	1.2043409223770873	[720]	[639,305]	7	hSpCas9	negative selection	1287143
23689242	23689265	16	+	26627737	RPE1	viability after 15 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-2.2418257556394776	[1008]	[40,78]	-8	hSpCas9	negative selection	1287145
23679195	23679218	16	+	26627737	RPE1	viability after 18 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	2.068367824910288	[146]	[162,169]	8	hSpCas9	negative selection	1369455
23679331	23679354	16	-	26627737	RPE1	viability after 18 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-3.433169142078425	[1383]	[65,0]	-9	hSpCas9	negative selection	1369456
23680978	23681001	16	+	26627737	RPE1	viability after 18 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-6.0093487208022855	[361]	[1,0]	-9	hSpCas9	negative selection	1369457
23684028	23684051	16	+	26627737	RPE1	viability after 18 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	0.9163058152372311	[720]	[358,375]	5	hSpCas9	negative selection	1369458
23689242	23689265	16	+	26627737	RPE1	viability after 18 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-1.7365018774295697	[1008]	[87,74]	-8	hSpCas9	negative selection	1369460
23679195	23679218	16	+	26627737	HeLa	viability after 8 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	-1.1920373131412323	[396]	[52,50,114]	-8	hSpCas9	negative selection	1451770
23679331	23679354	16	-	26627737	HeLa	viability after 8 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-1.9573708762270887	[611]	[76,97,34]	-9	hSpCas9	negative selection	1451771
23680978	23681001	16	+	26627737	HeLa	viability after 8 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-1.6474118804511018	[319]	[80,24,35]	-9	hSpCas9	negative selection	1451772
23684028	23684051	16	+	26627737	HeLa	viability after 8 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	0.28889349688038646	[552]	[331,333,228]	2	hSpCas9	negative selection	1451773
23689242	23689265	16	+	26627737	HeLa	viability after 8 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-2.2082748273784976	[614]	[6,0,147]	-9	hSpCas9	negative selection	1451775
23679195	23679218	16	+	26627737	HeLa	viability after 12 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	-3.2999696682431834	[396]	[0,30,15]	-9	hSpCas9	negative selection	1534085
23679331	23679354	16	-	26627737	HeLa	viability after 12 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-3.4219722006860227	[611]	[0,5,64]	-9	hSpCas9	negative selection	1534086
23680978	23681001	16	+	26627737	HeLa	viability after 12 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-1.643195402595067	[319]	[36,40,48]	-9	hSpCas9	negative selection	1534087
23684028	23684051	16	+	26627737	HeLa	viability after 12 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	0.5210490526670799	[552]	[460,211,326]	4	hSpCas9	negative selection	1534088
23689242	23689265	16	+	26627737	HeLa	viability after 12 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-3.188600947364628	[614]	[15,39,25]	-9	hSpCas9	negative selection	1534090
23679195	23679218	16	+	26627737	HeLa	viability after 15 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	-2.6317867407796833	[396]	[0,33,44]	-9	hSpCas9	negative selection	1616400
23679331	23679354	16	-	26627737	HeLa	viability after 15 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-2.369806453576517	[611]	[33,47,63]	-9	hSpCas9	negative selection	1616401
23680978	23681001	16	+	26627737	HeLa	viability after 15 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-2.0972412880810287	[319]	[36,50,0]	-9	hSpCas9	negative selection	1616402
23684028	23684051	16	+	26627737	HeLa	viability after 15 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	0.6394441422352233	[552]	[606,220,209]	5	hSpCas9	negative selection	1616403
23689242	23689265	16	+	26627737	HeLa	viability after 15 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-2.0576045952238626	[614]	[33,119,23]	-9	hSpCas9	negative selection	1616405
23679195	23679218	16	+	26627737	HeLa	viability after 18 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	-2.6259184474741772	[396]	[0,27,44]	-9	hSpCas9	negative selection	1698715
23679331	23679354	16	-	26627737	HeLa	viability after 18 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-2.348561896333211	[611]	[19,44,63]	-9	hSpCas9	negative selection	1698716
23680978	23681001	16	+	26627737	HeLa	viability after 18 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-2.3410828867917615	[319]	[18,37,0]	-9	hSpCas9	negative selection	1698717
23684028	23684051	16	+	26627737	HeLa	viability after 18 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	0.6248358416764683	[552]	[405,175,209]	5	hSpCas9	negative selection	1698718
23689242	23689265	16	+	26627737	HeLa	viability after 18 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-2.0663046404413916	[614]	[23,96,23]	-9	hSpCas9	negative selection	1698720
23679195	23679218	16	+	26627737	HCT116	viability after 6 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	-5.314402714272778	[612]	[4,0]	-9	hSpCas9	negative selection	1781030
23679331	23679354	16	-	26627737	HCT116	viability after 6 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-2.574985424639019	[650]	[31,8]	-8	hSpCas9	negative selection	1781031
23680978	23681001	16	+	26627737	HCT116	viability after 6 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-1.458772166158236	[428]	[10,31]	-7	hSpCas9	negative selection	1781032
23684028	23684051	16	+	26627737	HCT116	viability after 6 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	0.27712862182756515	[643]	[297,25]	1	hSpCas9	negative selection	1781033
23689242	23689265	16	+	26627737	HCT116	viability after 6 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-2.7897166690681807	[856]	[52,0]	-9	hSpCas9	negative selection	1781035
23679195	23679218	16	+	26627737	HCT116	viability after 8 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	-1.4239143154897747	[307]	[57,95,35]	-9	hSpCas9	negative selection	1863345
23679331	23679354	16	-	26627737	HCT116	viability after 8 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-1.7711327773026593	[319]	[54,44,54]	-9	hSpCas9	negative selection	1863346
23680978	23681001	16	+	26627737	HCT116	viability after 8 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-4.028977798103697	[413]	[18,7,14]	-9	hSpCas9	negative selection	1863347
23684028	23684051	16	+	26627737	HCT116	viability after 8 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	0.5360571861605609	[368]	[314,287,281]	5	hSpCas9	negative selection	1863348
23689242	23689265	16	+	26627737	HCT116	viability after 8 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-3.864416686628795	[510]	[10,39,6]	-9	hSpCas9	negative selection	1863350
23679195	23679218	16	+	26627737	HCT116	viability after 9 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	-1.4918508691061316	[612]	[41,70]	-8	hSpCas9	negative selection	1945660
23679331	23679354	16	-	26627737	HCT116	viability after 9 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-2.5697157853590937	[650]	[59,4]	-9	hSpCas9	negative selection	1945661
23680978	23681001	16	+	26627737	HCT116	viability after 9 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-3.9269007604153003	[428]	[11,3]	-9	hSpCas9	negative selection	1945662
23684028	23684051	16	+	26627737	HCT116	viability after 9 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	0.9007048555756659	[643]	[229,392]	6	hSpCas9	negative selection	1945663
23689242	23689265	16	+	26627737	HCT116	viability after 9 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-3.6996245569144226	[856]	[6,25]	-9	hSpCas9	negative selection	1945665
23679195	23679218	16	+	26627737	HCT116	viability after 12 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	-2.056510159951285	[307]	[26,47,42]	-9	hSpCas9	negative selection	2027975
23679331	23679354	16	-	26627737	HCT116	viability after 12 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-2.3957349318193875	[319]	[45,46,1]	-9	hSpCas9	negative selection	2027976
23680978	23681001	16	+	26627737	HCT116	viability after 12 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-2.9693694786266214	[413]	[16,15,50]	-9	hSpCas9	negative selection	2027977
23684028	23684051	16	+	26627737	HCT116	viability after 12 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	0.9470828314154537	[368]	[443,313,355]	7	hSpCas9	negative selection	2027978
23689242	23689265	16	+	26627737	HCT116	viability after 12 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-3.835569556810191	[510]	[8,47,0]	-9	hSpCas9	negative selection	2027980
23679195	23679218	16	+	26627737	HCT116	viability after 15 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	-2.0539620832177103	[307]	[20,47,55]	-9	hSpCas9	negative selection	2110290
23679331	23679354	16	-	26627737	HCT116	viability after 15 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-3.0114603102704702	[319]	[33,34,0]	-9	hSpCas9	negative selection	2110291
23680978	23681001	16	+	26627737	HCT116	viability after 15 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-4.989363064969442	[413]	[3,7,9]	-9	hSpCas9	negative selection	2110292
23684028	23684051	16	+	26627737	HCT116	viability after 15 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	0.621370590368412	[368]	[470,228,295]	5	hSpCas9	negative selection	2110293
23689242	23689265	16	+	26627737	HCT116	viability after 15 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-3.168761717304402	[510]	[38,53,5]	-9	hSpCas9	negative selection	2110295
23679195	23679218	16	+	26627737	HCT116	viability after 18 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	-3.6269080296476037	[307]	[11,21,0]	-9	hSpCas9	negative selection	2192605
23679331	23679354	16	-	26627737	HCT116	viability after 18 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-0.6374752105590367	[319]	[100,58,142]	-5	hSpCas9	negative selection	2192606
23680978	23681001	16	+	26627737	HCT116	viability after 18 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-4.9779639137188765	[413]	[0,8,8]	-9	hSpCas9	negative selection	2192607
23684028	23684051	16	+	26627737	HCT116	viability after 18 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	1.1987365436829056	[368]	[548,278,408]	8	hSpCas9	negative selection	2192608
23689242	23689265	16	+	26627737	HCT116	viability after 18 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-5.031663177328349	[510]	[7,12,0]	-9	hSpCas9	negative selection	2192610
23678933	23678956	16	+	24336569	HL60	viability	ATGAGTGCTGCAGTGACTGCAGG	PLK1	ENSG00000166851	-0.28247265150591905	[172]	[300]	-2	hSpCas9	negative selection	2284604
23678941	23678964	16	+	24336569	HL60	viability	TGCAGTGACTGCAGGGAAGCTGG	PLK1	ENSG00000166851	0.3944352940672959	[585]	[1629]	3	hSpCas9	negative selection	2284605
23678946	23678969	16	+	24336569	HL60	viability	TGACTGCAGGGAAGCTGGCACGG	PLK1	ENSG00000166851	-1.5582352407462703	[1129]	[811]	-8	hSpCas9	negative selection	2284606
23678953	23678976	16	+	24336569	HL60	viability	AGGGAAGCTGGCACGGGCACCGG	PLK1	ENSG00000166851	-0.7280656671424383	[525]	[671]	-6	hSpCas9	negative selection	2284607
23678972	23678995	16	-	24336569	HL60	viability	CCGGCTTTCCCAGGGTCGGCCGG	PLK1	ENSG00000166851	0.21236345875050056	[196]	[482]	2	hSpCas9	negative selection	2284608
23678999	23679022	16	-	24336569	HL60	viability	GCTCCGGGAGCTGCAACTCCGGG	PLK1	ENSG00000166851	0.41519887434309494	[538]	[1520]	4	hSpCas9	negative selection	2284609
23679007	23679030	16	+	24336569	HL60	viability	TGCAGCTCCCGGAGCTCCGGCGG	PLK1	ENSG00000166851	-1.5424024505163483	[478]	[347]	-8	hSpCas9	negative selection	2284610
23679060	23679083	16	+	24336569	HL60	viability	TCCTAGTGGACCCACGCAGCCGG	PLK1	ENSG00000166851	-0.01689209933281255	[141]	[296]	0	hSpCas9	negative selection	2284611
23679070	23679093	16	-	24336569	HL60	viability	CATAGCGCCGCCGGCTGCGTGGG	PLK1	ENSG00000166851	-1.9063132899610928	[642]	[362]	-9	hSpCas9	negative selection	2284612
23679076	23679099	16	+	24336569	HL60	viability	CAGCCGGCGGCGCTATGTGCGGG	PLK1	ENSG00000166851	-3.1935450274989243	[989]	[228]	-9	hSpCas9	negative selection	2284613
23678933	23678956	16	+	24336569	KBM7	viability	ATGAGTGCTGCAGTGACTGCAGG	PLK1	ENSG00000166851	-0.17598277721166466	[69]	[168]	-1	hSpCas9	negative selection	2351781
23678941	23678964	16	+	24336569	KBM7	viability	TGCAGTGACTGCAGGGAAGCTGG	PLK1	ENSG00000166851	0.40276252961726833	[443]	[1600]	4	hSpCas9	negative selection	2351782
23678946	23678969	16	+	24336569	KBM7	viability	TGACTGCAGGGAAGCTGGCACGG	PLK1	ENSG00000166851	-1.4493439613449477	[817]	[816]	-7	hSpCas9	negative selection	2351783
23678953	23678976	16	+	24336569	KBM7	viability	AGGGAAGCTGGCACGGGCACCGG	PLK1	ENSG00000166851	-1.6511125906340147	[493]	[428]	-8	hSpCas9	negative selection	2351784
23678972	23678995	16	-	24336569	KBM7	viability	CCGGCTTTCCCAGGGTCGGCCGG	PLK1	ENSG00000166851	1.972509921913177	[97]	[1048]	9	hSpCas9	negative selection	2351785
23678999	23679022	16	-	24336569	KBM7	viability	GCTCCGGGAGCTGCAACTCCGGG	PLK1	ENSG00000166851	-0.37237686989535235	[569]	[1200]	-3	hSpCas9	negative selection	2351786
23679007	23679030	16	+	24336569	KBM7	viability	TGCAGCTCCCGGAGCTCCGGCGG	PLK1	ENSG00000166851	-2.215056094931737	[222]	[130]	-8	hSpCas9	negative selection	2351787
23679060	23679083	16	+	24336569	KBM7	viability	TCCTAGTGGACCCACGCAGCCGG	PLK1	ENSG00000166851	-4.090152420440134	[280]	[44]	-9	hSpCas9	negative selection	2351788
23679070	23679093	16	-	24336569	KBM7	viability	CATAGCGCCGCCGGCTGCGTGGG	PLK1	ENSG00000166851	-2.9194027219193033	[379]	[136]	-9	hSpCas9	negative selection	2351789
23679076	23679099	16	+	24336569	KBM7	viability	CAGCCGGCGGCGCTATGTGCGGG	PLK1	ENSG00000166851	-4.58361382992157	[588]	[66]	-9	hSpCas9	negative selection	2351790
23678718	23678741	16	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGTTTTCCCCGGCTGGGTCCGGG	PLK1	ENSG00000166851	-1.1900797628964068	[35,0]	[1,0]	-7	dCas9-VP64	positive selection	2437170
23678742	23678765	16	+	25494202	A375	resistance to PLX-4720 (puromycin)	TTAAAGGCTGCTGCTGCGCAGGG	PLK1	ENSG00000166851	2.7914456149583557	[26,18]	[5,66]	8	dCas9-VP64	positive selection	2437171
23678697	23678720	16	+	25494202	A375	resistance to PLX-4720 (puromycin)	TTCGGGCGTCCGTGTCAATCAGG	PLK1	ENSG00000166851	-1.471236576519972	[62,193]	[1,17]	-8	dCas9-VP64	positive selection	2437172
23683250	23683273	16	-	25494202	A375	resistance to PLX-4720 (puromycin)	CGCCTGTAATCTCAGCACTTAGG	PLK1	ENSG00000166851	-0.6796005969874881	[92,259]	[10,38]	-3	dCas9-VP64	positive selection	2447687
23685580	23685603	16	+	25494202	A375	resistance to PLX-4720 (puromycin)	CACCTGTAATCTCAGCTACTCGG	PLK1	ENSG00000166851	-0.32009396436001514	[73,465]	[65,28]	-1	dCas9-VP64	positive selection	2454619
23678718	23678741	16	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGTTTTCCCCGGCTGGGTCCGGG	PLK1	ENSG00000166851	0.6471393952384155	[10,9]	[3,5]	5	dCas9-VP64	positive selection	2532425
23678742	23678765	16	+	25494202	A375	resistance to PLX-4720 (zeocin)	TTAAAGGCTGCTGCTGCGCAGGG	PLK1	ENSG00000166851	-0.8873575622040704	[48,110]	[15,11]	-8	dCas9-VP64	positive selection	2532426
23678697	23678720	16	+	25494202	A375	resistance to PLX-4720 (zeocin)	TTCGGGCGTCCGTGTCAATCAGG	PLK1	ENSG00000166851	-0.8432464730828376	[190,91]	[35,14]	-7	dCas9-VP64	positive selection	2532427
23683250	23683273	16	-	25494202	A375	resistance to PLX-4720 (zeocin)	CGCCTGTAATCTCAGCACTTAGG	PLK1	ENSG00000166851	0.2134968510682193	[79,136]	[55,26]	1	dCas9-VP64	positive selection	2542942
23685580	23685603	16	+	25494202	A375	resistance to PLX-4720 (zeocin)	CACCTGTAATCTCAGCTACTCGG	PLK1	ENSG00000166851	-0.35714226545986627	[161,80]	[51,10]	-4	dCas9-VP64	positive selection	2549874
23678933	23678956	16	+	27013184	SW480	treatment with recombinant TRAIL	ATGAGTGCTGCAGTGACTGCAGG	PLK1	ENSG00000166851	3.5547483151447676	[26,48]	[273,64]	9	hSpCas9	positive selection	2963725
23679152	23679175	16	+	27013184	SW480	treatment with recombinant TRAIL	GACACCAAGGAGGTGTTCGCGGG	PLK1	ENSG00000166851	1.4532218908898062	[310,229]	[301,354]	6	hSpCas9	positive selection	2963726
23679195	23679218	16	+	27013184	SW480	treatment with recombinant TRAIL	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	0.5136363321070878	[138,103]	[55,103]	2	hSpCas9	positive selection	2963727
23679254	23679277	16	+	27013184	SW480	treatment with recombinant TRAIL	CTCGCCCACCAGCACGTCGTAGG	PLK1	ENSG00000166851	-0.4094276091714214	[286,238]	[22,175]	-2	hSpCas9	positive selection	2963728
23679263	23679286	16	+	27013184	SW480	treatment with recombinant TRAIL	CAGCACGTCGTAGGATTCCACGG	PLK1	ENSG00000166851	-2.229807158787602	[24,135]	[1,13]	-8	hSpCas9	positive selection	2963729
23679295	23679318	16	+	27013184	SW480	treatment with recombinant TRAIL	GGACAACGACTTCGTGTTCGTGG	PLK1	ENSG00000166851	0.7462683184831727	[177,152]	[61,203]	3	hSpCas9	positive selection	2963731
23678941	23678964	16	+	27013184	SW480	treatment with recombinant TRAIL	TGCAGTGACTGCAGGGAAGCTGG	PLK1	ENSG00000166851	-1.9150691870909207	[296,282]	[50,7]	-7	hSpCas9	positive selection	2963732
23680071	23680094	16	+	27013184	SW480	treatment with recombinant TRAIL	TTCCCACCCACAGTCTCTCCTGG	PLK1	ENSG00000166851	0.3884918914772187	[214,278]	[42,272]	2	hSpCas9	positive selection	2963733
23680085	23680108	16	+	27013184	SW480	treatment with recombinant TRAIL	CTCTCCTGGAGCTGCACAAGAGG	PLK1	ENSG00000166851	-3.973603392844583	[64,175]	[3,1]	-9	hSpCas9	positive selection	2963734
23680088	23680111	16	+	27013184	SW480	treatment with recombinant TRAIL	TCCTGGAGCTGCACAAGAGGAGG	PLK1	ENSG00000166851	-1.2550311081615169	[127,127]	[37,1]	-5	hSpCas9	positive selection	2963737
23680127	23680150	16	+	27013184	SW480	treatment with recombinant TRAIL	CTGAGGCCCGATACTACCTACGG	PLK1	ENSG00000166851	-2.285657731836514	[38,2]	[1,1]	-8	hSpCas9	positive selection	2963738
23680141	23680164	16	+	27013184	SW480	treatment with recombinant TRAIL	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	2.2952372459603163	[162,126]	[345,259]	8	hSpCas9	positive selection	2963739
23680191	23680214	16	+	27013184	SW480	treatment with recombinant TRAIL	TATTCATCGAGACCTCAAGCTGG	PLK1	ENSG00000166851	-0.44781967403642997	[103,55]	[6,52]	-2	hSpCas9	positive selection	2963740
23680192	23680215	16	+	27013184	SW480	treatment with recombinant TRAIL	ATTCATCGAGACCTCAAGCTGGG	PLK1	ENSG00000166851	1.8434024100313042	[2,25]	[24,14]	7	hSpCas9	positive selection	2963741
23680218	23680241	16	+	27013184	SW480	treatment with recombinant TRAIL	CCTTTTCCTGAATGAAGATCTGG	PLK1	ENSG00000166851	0.9645984727968973	[424,266]	[352,217]	4	hSpCas9	positive selection	2963742
23680115	23680138	16	-	27013184	SW480	treatment with recombinant TRAIL	TCGGGCCTCAGGCTCAGTCAGGG	PLK1	ENSG00000166851	2.235193887511546	[1,1]	[1,6]	8	hSpCas9	positive selection	2963743
23680126	23680149	16	-	27013184	SW480	treatment with recombinant TRAIL	CGTAGGTAGTATCGGGCCTCAGG	PLK1	ENSG00000166851	0.695689873658853	[153,218]	[58,226]	3	hSpCas9	positive selection	2963744
23680133	23680156	16	-	27013184	SW480	treatment with recombinant TRAIL	AATTTGCCGTAGGTAGTATCGGG	PLK1	ENSG00000166851	-2.7686153859402505	[101,128]	[5,8]	-8	hSpCas9	positive selection	2963745
23680134	23680157	16	-	27013184	SW480	treatment with recombinant TRAIL	CAATTTGCCGTAGGTAGTATCGG	PLK1	ENSG00000166851	-3.4323836352715165	[179,211]	[1,15]	-9	hSpCas9	positive selection	2963746
23679046	23679069	16	+	27013184	SW480	treatment with recombinant TRAIL	AGAGATCCCGGAGGTCCTAGTGG	PLK1	ENSG00000166851	-1.0819969707136896	[126,25]	[25,2]	-5	hSpCas9	positive selection	2963748
23680143	23680166	16	-	27013184	SW480	treatment with recombinant TRAIL	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-2.5365047874333078	[88,21]	[5,1]	-8	hSpCas9	positive selection	2963749
23680173	23680196	16	-	27013184	SW480	treatment with recombinant TRAIL	GAATAACTCGGTTTCGGTGCAGG	PLK1	ENSG00000166851	0.49809938721568336	[41,66]	[53,1]	2	hSpCas9	positive selection	2963750
23680179	23680202	16	-	27013184	SW480	treatment with recombinant TRAIL	CTCGATGAATAACTCGGTTTCGG	PLK1	ENSG00000166851	-1.611494059974866	[423,548]	[50,91]	-6	hSpCas9	positive selection	2963751
23680185	23680208	16	-	27013184	SW480	treatment with recombinant TRAIL	TGAGGTCTCGATGAATAACTCGG	PLK1	ENSG00000166851	-2.179040821116741	[25,14]	[1,1]	-7	hSpCas9	positive selection	2963752
23680203	23680226	16	-	27013184	SW480	treatment with recombinant TRAIL	GGAAAAGGTTGCCCAGCTTGAGG	PLK1	ENSG00000166851	-1.606763988784842	[165,94]	[20,15]	-6	hSpCas9	positive selection	2963753
23680218	23680241	16	-	27013184	SW480	treatment with recombinant TRAIL	CCAGATCTTCATTCAGGAAAAGG	PLK1	ENSG00000166851	0.006592396628194663	[70,115]	[4,88]	0	hSpCas9	positive selection	2963754
23679060	23679083	16	+	27013184	SW480	treatment with recombinant TRAIL	TCCTAGTGGACCCACGCAGCCGG	PLK1	ENSG00000166851	0.2047479175389409	[280,301]	[127,167]	1	hSpCas9	positive selection	2963755
23679124	23679147	16	+	27013184	SW480	treatment with recombinant TRAIL	TGCCAAGTGCTTCGAGATCTCGG	PLK1	ENSG00000166851	1.9481883412983056	[115,280]	[371,241]	8	hSpCas9	positive selection	2963757
23679130	23679153	16	+	27013184	SW480	treatment with recombinant TRAIL	GTGCTTCGAGATCTCGGACGCGG	PLK1	ENSG00000166851	1.2994394813170775	[135,200]	[243,78]	6	hSpCas9	positive selection	2963758
23679151	23679174	16	+	27013184	SW480	treatment with recombinant TRAIL	GGACACCAAGGAGGTGTTCGCGG	PLK1	ENSG00000166851	-0.44731685834047274	[72,54]	[3,43]	-2	hSpCas9	positive selection	2963759
23679280	23679303	16	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CGTTGTCCTCGAAAAAGCCGTGG	PLK1	ENSG00000166851	-0.37552404270187856	[1,1]	[1,0]	-5	hSpCas9	positive selection	3012009
23683864	23683887	16	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	0.9387446008571024	[0,1]	[1,3]	9	hSpCas9	positive selection	3012010
23678975	23678998	16	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGCCGACCCTGGGAAAGCCGGGG	PLK1	ENSG00000166851	-0.16396987545289265	[2,0]	[1,0]	-2	hSpCas9	positive selection	3012011
23679320	23679343	16	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTTGGAGCTCTGCCGCCGGAGGG	PLK1	ENSG00000166851	-0.5617142054024289	[0,0]	[0,0]	-7	hSpCas9	positive selection	3012012
23679280	23679303	16	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CGTTGTCCTCGAAAAAGCCGTGG	PLK1	ENSG00000166851	0.2349586528963017	[1,1]	[2,0]	4	hSpCas9	positive selection	3079867
23683864	23683887	16	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	0.3897469637477151	[0,0]	[1,0]	6	hSpCas9	positive selection	3079868
23678975	23678998	16	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGCCGACCCTGGGAAAGCCGGGG	PLK1	ENSG00000166851	-0.49158897538302004	[2,2]	[1,0]	-7	hSpCas9	positive selection	3079869
23679320	23679343	16	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTTGGAGCTCTGCCGCCGGAGGG	PLK1	ENSG00000166851	-0.018809103285380768	[0,0]	[0,0]	0	hSpCas9	positive selection	3079870
23680143	23680166		-	24336571	A375	resistance to PLX after 7 days	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	0.18301840695859162	[2,3]	[4,2]	5	hSpCas9	positive selection	3136275
23681008	23681031		+	24336571	A375	resistance to PLX after 7 days	CAAGAAAGGGCACAGTTTCGAGG	PLK1	ENSG00000166851	-0.0016025743809928716	[4,3]	[4,3]	0	hSpCas9	positive selection	3136276
23680932	23680955		-	24336571	A375	resistance to PLX after 7 days	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	0.30259073069891673	[15,12]	[17,16]	8	hSpCas9	positive selection	3136277
23680141	23680164		+	24336571	A375	resistance to PLX after 7 days	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	0.4701800570442495	[2,6]	[5,7]	9	hSpCas9	positive selection	3136278
23680143	23680166		-	24336571	A375	resistance to PLX after 14 days	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	1.4833046202683846	[2,3]	[2,5]	9	hSpCas9	positive selection	3194068
23681008	23681031		+	24336571	A375	resistance to PLX after 14 days	CAAGAAAGGGCACAGTTTCGAGG	PLK1	ENSG00000166851	0.5837098280329619	[3,3]	[2,2]	5	hSpCas9	positive selection	3194069
23680932	23680955		-	24336571	A375	resistance to PLX after 14 days	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	1.6146203450757528	[7,9]	[11,13]	9	hSpCas9	positive selection	3194070
23680141	23680164		+	24336571	A375	resistance to PLX after 14 days	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	2.832844165204514	[2,3]	[14,12]	9	hSpCas9	positive selection	3194071
23680143	23680166		-	24336571	A375	viability after 7 days	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-1.9903477257597482	[15]	[2,3]	-9	hSpCas9	negative selection	3251861
23681008	23681031		+	24336571	A375	viability after 7 days	CAAGAAAGGGCACAGTTTCGAGG	PLK1	ENSG00000166851	-0.24759385524667277	[5]	[4,3]	-4	hSpCas9	negative selection	3251862
23680932	23680955		-	24336571	A375	viability after 7 days	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	0.006827332098332917	[14]	[15,12]	0	hSpCas9	negative selection	3251863
23680141	23680164		+	24336571	A375	viability after 7 days	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.2028428202855002	[12]	[2,6]	-9	hSpCas9	negative selection	3251864
23680143	23680166		-	24336571	A375	viability after 14 days	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-1.9961558769614116	[15]	[2,3]	-9	hSpCas9	negative selection	3309654
23681008	23681031		+	24336571	A375	viability after 14 days	CAAGAAAGGGCACAGTTTCGAGG	PLK1	ENSG00000166851	-0.4060940091441181	[5]	[3,3]	-5	hSpCas9	negative selection	3309655
23680932	23680955		-	24336571	A375	viability after 14 days	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.6239495018288166	[14]	[7,9]	-6	hSpCas9	negative selection	3309656
23680141	23680164		+	24336571	A375	viability after 14 days	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.4994097856914932	[12]	[2,3]	-9	hSpCas9	negative selection	3309657
23683937	23683960	16	-	27383988	293T	resistance to West Nile virus (flavivirus)	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-0.28956824844180157	[186,186]	[0,0]	-2	hSpCas9	positive selection	3386366
23680929	23680952	16	+	27383988	293T	resistance to West Nile virus (flavivirus)	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	1.3265888738829488	[60,60]	[0,0]	6	hSpCas9	positive selection	3386367
23682105	23682128	16	+	27383988	293T	resistance to West Nile virus (flavivirus)	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	0.5430806937797126	[104,104]	[0,0]	2	hSpCas9	positive selection	3386368
23679280	23679303	16	-	26780180	HT29	viability (Avana library 4 designs)	CGTTGTCCTCGAAAAAGCCGTGG	PLK1	ENSG00000166851	4.28681269045242	[]	[]	9	hSpCas9	negative selection	3450108
23683863	23683886	16	+	26780180	HT29	viability (Avana library 4 designs)	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	3.37942885309495	[]	[]	8	hSpCas9	negative selection	3450109
23678974	23678997	16	+	26780180	HT29	viability (Avana library 4 designs)	GGCCGACCCTGGGAAAGCCGGGG	PLK1	ENSG00000166851	3.40097285323381	[]	[]	8	hSpCas9	negative selection	3450110
23679319	23679342	16	+	26780180	HT29	viability (Avana library 4 designs)	GTTGGAGCTCTGCCGCCGGAGGG	PLK1	ENSG00000166851	4.9600951930237	[]	[]	9	hSpCas9	negative selection	3450111
23679280	23679303	16	-	26780180	A375	viability (Avana lentiCRISPRv2)	CGTTGTCCTCGAAAAAGCCGTGG	PLK1	ENSG00000166851	-12.86932187706	[]	[]	-8	hSpCas9	negative selection	3545192
23679319	23679342	16	+	26780180	A375	viability (Avana lentiCRISPRv2)	GTTGGAGCTCTGCCGCCGGAGGG	PLK1	ENSG00000166851	-13.6742276365196	[]	[]	-8	hSpCas9	negative selection	3545193
23683863	23683886	16	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	-12.8833746854415	[]	[]	-8	hSpCas9	negative selection	3545194
23678974	23678997	16	+	26780180	A375	viability (Avana lentiCRISPRv2)	GGCCGACCCTGGGAAAGCCGGGG	PLK1	ENSG00000166851	-2.01748316167423	[]	[]	-2	hSpCas9	negative selection	3545195
23679196	23679219	16	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCTGCTCAAGCCGCACCAGAGGG	PLK1	ENSG00000166851	-5.28858550613456	[]	[]	-5	hSpCas9	negative selection	3545196
23680909	23680932	16	-	26780180	A375	viability (Avana lentiCRISPRv2)	TTGCCAGTCCAAAATCCCCTGGG	PLK1	ENSG00000166851	-8.8796345468985	[]	[]	-7	hSpCas9	negative selection	3545197
23679280	23679303	16	-	26780180	A375	viability (Avana lentiGuide)	CGTTGTCCTCGAAAAAGCCGTGG	PLK1	ENSG00000166851	19.6619387902867	[]	[]	8	hSpCas9	negative selection	3653851
23679319	23679342	16	+	26780180	A375	viability (Avana lentiGuide)	GTTGGAGCTCTGCCGCCGGAGGG	PLK1	ENSG00000166851	31.5056321213079	[]	[]	9	hSpCas9	negative selection	3653852
23683863	23683886	16	+	26780180	A375	viability (Avana lentiGuide)	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	28.4258712099187	[]	[]	9	hSpCas9	negative selection	3653853
23678974	23678997	16	+	26780180	A375	viability (Avana lentiGuide)	GGCCGACCCTGGGAAAGCCGGGG	PLK1	ENSG00000166851	20.3119041023873	[]	[]	8	hSpCas9	negative selection	3653854
23679196	23679219	16	+	26780180	A375	viability (Avana lentiGuide)	GCTGCTCAAGCCGCACCAGAGGG	PLK1	ENSG00000166851	17.0585065305738	[]	[]	8	hSpCas9	negative selection	3653855
23680909	23680932	16	-	26780180	A375	viability (Avana lentiGuide)	TTGCCAGTCCAAAATCCCCTGGG	PLK1	ENSG00000166851	22.2194488313257	[]	[]	9	hSpCas9	negative selection	3653856
23679280	23679303	16	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CGTTGTCCTCGAAAAAGCCGTGG	PLK1	ENSG00000166851	-1.7798768803543026	[4]	[0,0]	-9	hSpCas9	positive selection	3762510
23679319	23679342	16	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTTGGAGCTCTGCCGCCGGAGGG	PLK1	ENSG00000166851	-2.3642765410329796	[4]	[0,0]	-9	hSpCas9	positive selection	3762511
23683863	23683886	16	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	-1.8410390064491733	[4]	[0,0]	-9	hSpCas9	positive selection	3762512
23678974	23678997	16	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGCCGACCCTGGGAAAGCCGGGG	PLK1	ENSG00000166851	-0.19607660995201814	[3]	[3,2]	-3	hSpCas9	positive selection	3762513
23679196	23679219	16	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCTGCTCAAGCCGCACCAGAGGG	PLK1	ENSG00000166851	-0.29293304300166156	[5]	[4,3]	-4	hSpCas9	positive selection	3762514
23680909	23680932	16	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTGCCAGTCCAAAATCCCCTGGG	PLK1	ENSG00000166851	-0.6412943717594888	[5]	[3,2]	-7	hSpCas9	positive selection	3762515
23679280	23679303	16	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CGTTGTCCTCGAAAAAGCCGTGG	PLK1	ENSG00000166851	-0.8005059532195995	[4]	[0,2]	-7	hSpCas9	positive selection	3871117
23679319	23679342	16	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTTGGAGCTCTGCCGCCGGAGGG	PLK1	ENSG00000166851	-2.3129647963847004	[4]	[0,0]	-9	hSpCas9	positive selection	3871118
23683863	23683886	16	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	-2.045408873659597	[5]	[0,0]	-9	hSpCas9	positive selection	3871119
23678974	23678997	16	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGCCGACCCTGGGAAAGCCGGGG	PLK1	ENSG00000166851	-0.9142524235615552	[4]	[2,0]	-8	hSpCas9	positive selection	3871120
23679196	23679219	16	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCTGCTCAAGCCGCACCAGAGGG	PLK1	ENSG00000166851	-0.583045112106193	[6]	[5,0]	-6	hSpCas9	positive selection	3871121
23680909	23680932	16	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTGCCAGTCCAAAATCCCCTGGG	PLK1	ENSG00000166851	-0.818828344526257	[6]	[2,2]	-8	hSpCas9	positive selection	3871122
23680143	23680166	16	-	26780180	A375	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	2.55770309955587	[]	[]	9	hSpCas9	negative selection	3981947
23680929	23680952	16	+	26780180	A375	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	1.4546653492587	[]	[]	8	hSpCas9	negative selection	3981948
23680932	23680955	16	-	26780180	A375	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	2.8280638833221	[]	[]	9	hSpCas9	negative selection	3981949
23682105	23682128	16	+	26780180	A375	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	2.57789868447152	[]	[]	9	hSpCas9	negative selection	3981950
23683937	23683960	16	-	26780180	A375	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	2.11300230266325	[]	[]	9	hSpCas9	negative selection	3981951
23680141	23680164	16	+	26780180	A375	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	2.80962702338948	[]	[]	9	hSpCas9	negative selection	3981952
23680143	23680166	16	-	26780180	HT29	viability (GeCKOv2 library)	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	2.78297662958569	[]	[]	9	hSpCas9	negative selection	4089913
23680929	23680952	16	+	26780180	HT29	viability (GeCKOv2 library)	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	0.918481311897127	[]	[]	4	hSpCas9	negative selection	4089914
23680932	23680955	16	-	26780180	HT29	viability (GeCKOv2 library)	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	2.37666578154437	[]	[]	9	hSpCas9	negative selection	4089915
23682105	23682128	16	+	26780180	HT29	viability (GeCKOv2 library)	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	3.59740145538357	[]	[]	9	hSpCas9	negative selection	4089916
23683937	23683960	16	-	26780180	HT29	viability (GeCKOv2 library)	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	1.74938244562613	[]	[]	8	hSpCas9	negative selection	4089917
23680141	23680164	16	+	26780180	HT29	viability (GeCKOv2 library)	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	3.20542023761901	[]	[]	9	hSpCas9	negative selection	4089918
23680143	23680166	16	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	0.3877499377104746	[1]	[0,1]	8	hSpCas9	positive selection	4161294
23681008	23681031	16	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CAAGAAAGGGCACAGTTTCGAGG	PLK1	ENSG00000166851	0.04689972725839975	[2]	[1,1]	1	hSpCas9	positive selection	4161295
23680932	23680955	16	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	0.13566766130904592	[3]	[1,3]	3	hSpCas9	positive selection	4161296
23680141	23680164	16	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	0.7924097396206458	[2]	[1,3]	9	hSpCas9	positive selection	4161297
23680143	23680166	16	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	1.6480607658842992	[2]	[0,0,5,4]	9	hSpCas9	positive selection	4225316
23681008	23681031	16	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CAAGAAAGGGCACAGTTTCGAGG	PLK1	ENSG00000166851	1.6527801154095758	[1]	[0,0,1,3]	9	hSpCas9	positive selection	4225317
23680932	23680955	16	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.1890925638191108	[3]	[2,0,0,0]	-3	hSpCas9	positive selection	4225318
23680141	23680164	16	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	0.9356745795801943	[1]	[0,0,3,0]	6	hSpCas9	positive selection	4225319
23680932	23680955	16	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.4771833127471421	[4]	[2,2]	-8	hSpCas9	positive selection	4290834
23680143	23680166	16	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-0.4235632277448179	[4]	[2,1]	-7	hSpCas9	positive selection	4290835
23680141	23680164	16	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-0.5565454748987504	[4]	[2,1]	-8	hSpCas9	positive selection	4290836
23683937	23683960	16	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-0.33161201041185095	[4]	[2,2]	-6	hSpCas9	positive selection	4355085
23680929	23680952	16	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.47421547553878113	[2]	[1,0]	-8	hSpCas9	positive selection	4355086
23682105	23682128	16	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.9627414525420596	[3]	[1,0]	-9	hSpCas9	positive selection	4355087
23679143	23679165	16	+	27760321	OCIAML3	viability	TCGGACGCGGACACCAAGGAGG	PLK1	ENSG00000166851	-3.24483452108016	[367,342]	[24,34]	-9	hSpCas9	negative selection	4428674
23679259	23679281	16	-	27760321	OCIAML3	viability	GAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-0.9094115440252241	[716,693]	[200,415]	-7	hSpCas9	negative selection	4428675
23680126	23680148	16	-	27760321	OCIAML3	viability	GTAGGTAGTATCGGGCCTCAGG	PLK1	ENSG00000166851	-0.8196000848808556	[669,548]	[207,347]	-6	hSpCas9	negative selection	4428676
23680173	23680195	16	-	27760321	OCIAML3	viability	AATAACTCGGTTTCGGTGCAGG	PLK1	ENSG00000166851	-1.2599156108716558	[535,484]	[120,225]	-8	hSpCas9	negative selection	4428677
23680931	23680953	16	+	27760321	OCIAML3	viability	ACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-1.5272993230410337	[212,179]	[20,94]	-8	hSpCas9	negative selection	4428678
23679143	23679165	16	+	27760321	OCIAML2	viability	TCGGACGCGGACACCAAGGAGG	PLK1	ENSG00000166851	-1.7926642645641788	[367,342]	[76,90]	-9	hSpCas9	negative selection	4512137
23679259	23679281	16	-	27760321	OCIAML2	viability	GAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-0.997573010711638	[716,693]	[269,307]	-7	hSpCas9	negative selection	4512138
23680126	23680148	16	-	27760321	OCIAML2	viability	GTAGGTAGTATCGGGCCTCAGG	PLK1	ENSG00000166851	-2.5957901178472444	[669,548]	[56,112]	-9	hSpCas9	negative selection	4512139
23680173	23680195	16	-	27760321	OCIAML2	viability	AATAACTCGGTTTCGGTGCAGG	PLK1	ENSG00000166851	-2.5897849515644453	[535,484]	[30,117]	-9	hSpCas9	negative selection	4512140
23680931	23680953	16	+	27760321	OCIAML2	viability	ACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-1.6083727158547338	[212,179]	[38,68]	-8	hSpCas9	negative selection	4512141
23679143	23679165	16	+	27760321	MV411	viability	TCGGACGCGGACACCAAGGAGG	PLK1	ENSG00000166851	-0.9569244496968943	[367,342]	[0,300]	-6	hSpCas9	negative selection	4595600
23679259	23679281	16	-	27760321	MV411	viability	GAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-1.2562750557744864	[716,693]	[42,423]	-7	hSpCas9	negative selection	4595601
23680126	23680148	16	-	27760321	MV411	viability	GTAGGTAGTATCGGGCCTCAGG	PLK1	ENSG00000166851	-1.7544622176295066	[669,548]	[152,66]	-8	hSpCas9	negative selection	4595602
23680173	23680195	16	-	27760321	MV411	viability	AATAACTCGGTTTCGGTGCAGG	PLK1	ENSG00000166851	-1.5657399072975324	[535,484]	[0,282]	-7	hSpCas9	negative selection	4595603
23680931	23680953	16	+	27760321	MV411	viability	ACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-1.6998409851880742	[212,179]	[4,91]	-8	hSpCas9	negative selection	4595604
23679143	23679165	16	+	27760321	HL60	viability	TCGGACGCGGACACCAAGGAGG	PLK1	ENSG00000166851	-2.8467255904023228	[367,342]	[19,61]	-9	hSpCas9	negative selection	4679063
23679259	23679281	16	-	27760321	HL60	viability	GAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-1.423257602934433	[716,693]	[241,186]	-8	hSpCas9	negative selection	4679064
23680126	23680148	16	-	27760321	HL60	viability	GTAGGTAGTATCGGGCCTCAGG	PLK1	ENSG00000166851	-3.131766268368815	[669,548]	[73,37]	-9	hSpCas9	negative selection	4679065
23680173	23680195	16	-	27760321	HL60	viability	AATAACTCGGTTTCGGTGCAGG	PLK1	ENSG00000166851	-1.6489966675433783	[535,484]	[61,207]	-9	hSpCas9	negative selection	4679066
23680931	23680953	16	+	27760321	HL60	viability	ACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-2.9856159209887276	[212,179]	[9,30]	-9	hSpCas9	negative selection	4679067
23679143	23679165	16	+	27760321	HT1080	viability	TCGGACGCGGACACCAAGGAGG	PLK1	ENSG00000166851	-2.657329989027793	[342,267]	[35,0]	-7	hSpCas9	negative selection	4762526
23679259	23679281	16	-	27760321	HT1080	viability	GAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-3.528353385189306	[693,541]	[38,1]	-7	hSpCas9	negative selection	4762527
23680126	23680148	16	-	27760321	HT1080	viability	GTAGGTAGTATCGGGCCTCAGG	PLK1	ENSG00000166851	-7.605983057862544	[548,428]	[0,0]	-9	hSpCas9	negative selection	4762528
23680173	23680195	16	-	27760321	HT1080	viability	AATAACTCGGTTTCGGTGCAGG	PLK1	ENSG00000166851	-2.691977343970029	[484,378]	[39,11]	-7	hSpCas9	negative selection	4762529
23680931	23680953	16	+	27760321	HT1080	viability	ACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-5.998940211991752	[179,140]	[0,0]	-9	hSpCas9	negative selection	4762530
23679143	23679165	16	+	27760321	HT29	viability after 7 days	TCGGACGCGGACACCAAGGAGG	PLK1	ENSG00000166851	-3.169441456683789	[342,267]	[70,25,37]	-9	hSpCas9	negative selection	4845989
23679259	23679281	16	-	27760321	HT29	viability after 7 days	GAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-4.220144353530612	[693,541]	[62,64,3]	-9	hSpCas9	negative selection	4845990
23680126	23680148	16	-	27760321	HT29	viability after 7 days	GTAGGTAGTATCGGGCCTCAGG	PLK1	ENSG00000166851	-7.872966126147033	[548,428]	[1,4,0]	-9	hSpCas9	negative selection	4845991
23680173	23680195	16	-	27760321	HT29	viability after 7 days	AATAACTCGGTTTCGGTGCAGG	PLK1	ENSG00000166851	-6.095243639811087	[484,378]	[24,0,0]	-9	hSpCas9	negative selection	4845992
23680931	23680953	16	+	27760321	HT29	viability after 7 days	ACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-2.5129543061033965	[179,140]	[28,60,17]	-9	hSpCas9	negative selection	4845993
23679143	23679165	16	+	27760321	HT29	viability after 25 days	TCGGACGCGGACACCAAGGAGG	PLK1	ENSG00000166851	-4.497172017532355	[342,267]	[33,5,3]	-9	hSpCas9	negative selection	4929452
23679259	23679281	16	-	27760321	HT29	viability after 25 days	GAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-3.5123564934135434	[693,541]	[70,103,3]	-9	hSpCas9	negative selection	4929453
23680126	23680148	16	-	27760321	HT29	viability after 25 days	GTAGGTAGTATCGGGCCTCAGG	PLK1	ENSG00000166851	-6.371811564946952	[548,428]	[0,17,0]	-9	hSpCas9	negative selection	4929454
23680173	23680195	16	-	27760321	HT29	viability after 25 days	AATAACTCGGTTTCGGTGCAGG	PLK1	ENSG00000166851	-8.946864745118322	[484,378]	[0,0,0]	-9	hSpCas9	negative selection	4929455
23680931	23680953	16	+	27760321	HT29	viability after 25 days	ACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-2.208755937230099	[179,140]	[72,11,30]	-8	hSpCas9	negative selection	4929456
23679143	23679165	16	+	27760321	HT29	viability after 22 days	TCGGACGCGGACACCAAGGAGG	PLK1	ENSG00000166851	-4.155169917049746	[342,267]	[0,36,21]	-9	hSpCas9	negative selection	5012915
23679259	23679281	16	-	27760321	HT29	viability after 22 days	GAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-3.148489513466027	[693,541]	[168,23,45]	-8	hSpCas9	negative selection	5012916
23680126	23680148	16	-	27760321	HT29	viability after 22 days	GTAGGTAGTATCGGGCCTCAGG	PLK1	ENSG00000166851	-9.142983954568328	[548,428]	[0,0,0]	-9	hSpCas9	negative selection	5012917
23680173	23680195	16	-	27760321	HT29	viability after 22 days	AATAACTCGGTTTCGGTGCAGG	PLK1	ENSG00000166851	-8.964183376977582	[484,378]	[0,0,0]	-9	hSpCas9	negative selection	5012918
23680931	23680953	16	+	27760321	HT29	viability after 22 days	ACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-1.9259895875180162	[179,140]	[0,77,68]	-8	hSpCas9	negative selection	5012919
23679143	23679165	16	+	27760321	HT29	viability after 19 days	TCGGACGCGGACACCAAGGAGG	PLK1	ENSG00000166851	-2.6269157799416845	[342,267]	[0,163,0]	-8	hSpCas9	negative selection	5096378
23679259	23679281	16	-	27760321	HT29	viability after 19 days	GAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-3.8041005631607856	[693,541]	[15,23,105]	-9	hSpCas9	negative selection	5096379
23680126	23680148	16	-	27760321	HT29	viability after 19 days	GTAGGTAGTATCGGGCCTCAGG	PLK1	ENSG00000166851	-9.127143902145114	[548,428]	[0,0,0]	-9	hSpCas9	negative selection	5096380
23680173	23680195	16	-	27760321	HT29	viability after 19 days	AATAACTCGGTTTCGGTGCAGG	PLK1	ENSG00000166851	-8.948343324554369	[484,378]	[0,0,0]	-9	hSpCas9	negative selection	5096381
23680931	23680953	16	+	27760321	HT29	viability after 19 days	ACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-2.3733245021515135	[179,140]	[1,97,3]	-8	hSpCas9	negative selection	5096382
23679143	23679165	16	+	27760321	HT29	viability after 16 days	TCGGACGCGGACACCAAGGAGG	PLK1	ENSG00000166851	-3.4820322313229624	[342,267]	[72,21,0]	-9	hSpCas9	negative selection	5179841
23679259	23679281	16	-	27760321	HT29	viability after 16 days	GAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-3.352971109987177	[693,541]	[85,95,21]	-9	hSpCas9	negative selection	5179842
23680126	23680148	16	-	27760321	HT29	viability after 16 days	GTAGGTAGTATCGGGCCTCAGG	PLK1	ENSG00000166851	-5.029542935097157	[548,428]	[0,45,0]	-9	hSpCas9	negative selection	5179843
23680173	23680195	16	-	27760321	HT29	viability after 16 days	AATAACTCGGTTTCGGTGCAGG	PLK1	ENSG00000166851	-8.916878872133447	[484,378]	[0,0,0]	-9	hSpCas9	negative selection	5179844
23680931	23680953	16	+	27760321	HT29	viability after 16 days	ACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-3.050476497922558	[179,140]	[2,31,27]	-9	hSpCas9	negative selection	5179845
23679143	23679165	16	+	27760321	HT29	viability after 13 days	TCGGACGCGGACACCAAGGAGG	PLK1	ENSG00000166851	-3.953098577407462	[342,267]	[3,29,33]	-9	hSpCas9	negative selection	5263304
23679259	23679281	16	-	27760321	HT29	viability after 13 days	GAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-3.7980107098717326	[693,541]	[65,43,44]	-9	hSpCas9	negative selection	5263305
23680126	23680148	16	-	27760321	HT29	viability after 13 days	GTAGGTAGTATCGGGCCTCAGG	PLK1	ENSG00000166851	-9.14796684916833	[548,428]	[0,0,0]	-9	hSpCas9	negative selection	5263306
23680173	23680195	16	-	27760321	HT29	viability after 13 days	AATAACTCGGTTTCGGTGCAGG	PLK1	ENSG00000166851	-8.969166271577585	[484,378]	[0,0,0]	-9	hSpCas9	negative selection	5263307
23680931	23680953	16	+	27760321	HT29	viability after 13 days	ACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-2.426751847164982	[179,140]	[37,32,32]	-9	hSpCas9	negative selection	5263308
23679143	23679165	16	+	27760321	HT29	viability after 10 days	TCGGACGCGGACACCAAGGAGG	PLK1	ENSG00000166851	-3.4313363878114513	[342,267]	[43,29,31]	-9	hSpCas9	negative selection	5346767
23679259	23679281	16	-	27760321	HT29	viability after 10 days	GAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-3.4875950008405345	[693,541]	[33,76,94]	-9	hSpCas9	negative selection	5346768
23680126	23680148	16	-	27760321	HT29	viability after 10 days	GTAGGTAGTATCGGGCCTCAGG	PLK1	ENSG00000166851	-5.517677074967855	[548,428]	[34,3,0]	-9	hSpCas9	negative selection	5346769
23680173	23680195	16	-	27760321	HT29	viability after 10 days	AATAACTCGGTTTCGGTGCAGG	PLK1	ENSG00000166851	-5.993867516266075	[484,378]	[0,23,0]	-9	hSpCas9	negative selection	5346770
23680931	23680953	16	+	27760321	HT29	viability after 10 days	ACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-3.804175717435175	[179,140]	[39,1,0]	-9	hSpCas9	negative selection	5346771
23679143	23679165	16	+	27760321	MOLM13	viability	TCGGACGCGGACACCAAGGAGG	PLK1	ENSG00000166851	-3.345130012526458	[367,342]	[2,33]	-9	hSpCas9	negative selection	5430230
23679259	23679281	16	-	27760321	MOLM13	viability	GAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-1.361710039511382	[716,693]	[266,59]	-7	hSpCas9	negative selection	5430231
23680126	23680148	16	-	27760321	MOLM13	viability	GTAGGTAGTATCGGGCCTCAGG	PLK1	ENSG00000166851	-1.5008552159171331	[669,548]	[0,222]	-7	hSpCas9	negative selection	5430232
23680173	23680195	16	-	27760321	MOLM13	viability	AATAACTCGGTTTCGGTGCAGG	PLK1	ENSG00000166851	-2.7551067401476996	[535,484]	[13,66]	-8	hSpCas9	negative selection	5430233
23680931	23680953	16	+	27760321	MOLM13	viability	ACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-1.1779366343048028	[212,179]	[104,0]	-6	hSpCas9	negative selection	5430234
23679319	23679342	16	+	27661255	K562	viability	GTTGGAGCTCTGCCGCCGGAGGG	PLK1	ENSG00000166851	-1.559645197549264	[1134,1291]	[387,276]	-9	dCas9-KRAB	negative selection	5502612
23679337	23679360	16	+	27661255	K562	viability	GAGGGTGAGTGTCGCTGCTGGGG	PLK1	ENSG00000166851	-2.5924439727683133	[542,658]	[101,59]	-9	dCas9-KRAB	negative selection	5502613
23680932	23680955	16	-	27260156	BXPC3	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	0.07281675896164441	[1611]	[1596,1970,1851,1651]	1	hSpCas9	negative selection	5563294
23680143	23680166	16	-	27260156	BXPC3	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-1.179463864862935	[1002]	[453,522,438,424]	-9	hSpCas9	negative selection	5563295
23680141	23680164	16	+	27260156	BXPC3	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.4317660835914126	[1455]	[439,545,643,649]	-9	hSpCas9	negative selection	5563296
23683937	23683960	16	-	27260156	BXPC3	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-1.1426964987006114	[1460]	[606,504,895,790]	-9	hSpCas9	negative selection	5627545
23680929	23680952	16	+	27260156	BXPC3	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.3450176960072453	[252]	[241,212,177,191]	-6	hSpCas9	negative selection	5627546
23682105	23682128	16	+	27260156	BXPC3	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.9185218408213285	[581]	[342,282,343,314]	-9	hSpCas9	negative selection	5627547
23680932	23680955	16	-	27260156	A673	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.44582445563617923	[1611]	[1717,1148,1354,1505]	-8	hSpCas9	negative selection	5684545
23680143	23680166	16	-	27260156	A673	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-0.3861129665238189	[1002]	[957,879,893,959]	-7	hSpCas9	negative selection	5684546
23680141	23680164	16	+	27260156	A673	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-0.8290882788124146	[1455]	[1108,854,958,1031]	-9	hSpCas9	negative selection	5684547
23683937	23683960	16	-	27260156	A673	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-0.6113682988911919	[1460]	[1049,1307,997,1224]	-9	hSpCas9	negative selection	5748796
23680929	23680952	16	+	27260156	A673	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.5845831391408278	[252]	[243,210,169,188]	-8	hSpCas9	negative selection	5748797
23682105	23682128	16	+	27260156	A673	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.702458556786218	[581]	[533,430,346,416]	-9	hSpCas9	negative selection	5748798
23680932	23680955	16	-	27260156	A375	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.5281835886111661	[1611]	[1313,1734,1291,975]	-6	hSpCas9	negative selection	5805796
23680143	23680166	16	-	27260156	A375	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-1.77691613070039	[1002]	[270,446,364,301]	-9	hSpCas9	negative selection	5805797
23680141	23680164	16	+	27260156	A375	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.8819362201394658	[1455]	[447,480,451,464]	-9	hSpCas9	negative selection	5805798
23683937	23683960	16	-	27260156	A375	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-1.4103375090361632	[1460]	[802,722,502,558]	-9	hSpCas9	negative selection	5870047
23680929	23680952	16	+	27260156	A375	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-1.3190537730697405	[252]	[103,92,175,98]	-9	hSpCas9	negative selection	5870048
23682105	23682128	16	+	27260156	A375	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-1.2240164820274997	[581]	[232,319,354,261]	-8	hSpCas9	negative selection	5870049
23680932	23680955	16	-	27260156	COLO741	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.0967893031558138	[1611]	[2167,1800,1831]	-2	hSpCas9	negative selection	5927047
23680143	23680166	16	-	27260156	COLO741	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-0.8098046703514501	[1002]	[805,691,701]	-9	hSpCas9	negative selection	5927048
23680141	23680164	16	+	27260156	COLO741	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.2368149575319887	[1455]	[942,757,685]	-9	hSpCas9	negative selection	5927049
23683937	23683960	16	-	27260156	COLO741	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-0.6464875239049845	[1460]	[1532,1001,1076]	-8	hSpCas9	negative selection	5991298
23680929	23680952	16	+	27260156	COLO741	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-1.076811994657444	[252]	[148,169,140]	-9	hSpCas9	negative selection	5991299
23682105	23682128	16	+	27260156	COLO741	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.9800964198282165	[581]	[423,402,311]	-9	hSpCas9	negative selection	5991300
23680932	23680955	16	-	27260156	CAL120	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.03698902496186074	[1611]	[1744,2015,2069]	0	hSpCas9	negative selection	6048298
23680143	23680166	16	-	27260156	CAL120	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-2.250766689018942	[1002]	[353,159,285]	-9	hSpCas9	negative selection	6048299
23680141	23680164	16	+	27260156	CAL120	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.8572512205881804	[1455]	[444,506,538]	-9	hSpCas9	negative selection	6048300
23683937	23683960	16	-	27260156	CAL120	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-1.1154858496107352	[1460]	[1025,564,951]	-9	hSpCas9	negative selection	6112549
23680929	23680952	16	+	27260156	CAL120	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-1.2794187851064232	[252]	[88,112,179]	-9	hSpCas9	negative selection	6112550
23682105	23682128	16	+	27260156	CAL120	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-1.3012405164292542	[581]	[355,248,285]	-9	hSpCas9	negative selection	6112551
23680932	23680955	16	-	27260156	CADOES1	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.29682778560383705	[1611]	[893,1192,1485,1312]	-5	hSpCas9	negative selection	6169549
23680143	23680166	16	-	27260156	CADOES1	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-0.9896856915818345	[1002]	[560,407,483,423]	-9	hSpCas9	negative selection	6169550
23680141	23680164	16	+	27260156	CADOES1	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.4357393377627978	[1455]	[651,356,507,483]	-9	hSpCas9	negative selection	6169551
23683937	23683960	16	-	27260156	CADOES1	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-1.0832058987383828	[1460]	[508,664,665,728]	-9	hSpCas9	negative selection	6233800
23680929	23680952	16	+	27260156	CADOES1	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.3407136107866773	[252]	[219,155,157,209]	-5	hSpCas9	negative selection	6233801
23682105	23682128	16	+	27260156	CADOES1	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.41435101379287376	[581]	[315,423,297,593]	-6	hSpCas9	negative selection	6233802
23680932	23680955	16	-	27260156	EWS502	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.21494981844368244	[1611]	[1551,1329,1523,1468]	-4	hSpCas9	negative selection	6290800
23680143	23680166	16	-	27260156	EWS502	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-1.9184321360929963	[1002]	[239,274,316,297]	-9	hSpCas9	negative selection	6290801
23680141	23680164	16	+	27260156	EWS502	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-2.0399397283605176	[1455]	[293,501,325,380]	-9	hSpCas9	negative selection	6290802
23683937	23683960	16	-	27260156	EWS502	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-1.2327959677077431	[1460]	[522,618,656,864]	-9	hSpCas9	negative selection	6355051
23680929	23680952	16	+	27260156	EWS502	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-1.0270652506252844	[252]	[108,122,197,96]	-9	hSpCas9	negative selection	6355052
23682105	23682128	16	+	27260156	EWS502	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.929278071364688	[581]	[242,386,300,372]	-8	hSpCas9	negative selection	6355053
23680932	23680955	16	-	27260156	EW8	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.5320034802629854	[1611]	[1214,1044,678,745]	-7	hSpCas9	negative selection	6412051
23680143	23680166	16	-	27260156	EW8	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-1.128933244828433	[1002]	[402,465,334,291]	-9	hSpCas9	negative selection	6412052
23680141	23680164	16	+	27260156	EW8	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.4458326054882698	[1455]	[556,457,357,384]	-9	hSpCas9	negative selection	6412053
23683937	23683960	16	-	27260156	EW8	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-0.7897884236010706	[1460]	[667,850,611,617]	-8	hSpCas9	negative selection	6476302
23680929	23680952	16	+	27260156	EW8	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.6133019784246887	[252]	[122,134,94,187]	-8	hSpCas9	negative selection	6476303
23682105	23682128	16	+	27260156	EW8	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.7796917598168718	[581]	[282,290,275,248]	-8	hSpCas9	negative selection	6476304
23680932	23680955	16	-	27260156	CORL105	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.28566267271705903	[1611]	[1408,1503,1945,1391]	-5	hSpCas9	negative selection	6533302
23680143	23680166	16	-	27260156	CORL105	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-1.0764591871712088	[1002]	[651,410,769,433]	-9	hSpCas9	negative selection	6533303
23680141	23680164	16	+	27260156	CORL105	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.042760636679261	[1455]	[1087,773,695,740]	-9	hSpCas9	negative selection	6533304
23683937	23683960	16	-	27260156	CORL105	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-1.0657939240344778	[1460]	[813,760,868,832]	-9	hSpCas9	negative selection	6597553
23680929	23680952	16	+	27260156	CORL105	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-1.0457565122780457	[252]	[177,155,174,70]	-9	hSpCas9	negative selection	6597554
23682105	23682128	16	+	27260156	CORL105	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-1.2565519856478684	[581]	[380,250,223,278]	-9	hSpCas9	negative selection	6597555
23680932	23680955	16	-	27260156	HS294T	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.055244914128607325	[1611]	[533,557,614,717]	0	hSpCas9	negative selection	6654553
23680143	23680166	16	-	27260156	HS294T	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-1.0686590862537133	[1002]	[95,130,209,337]	-9	hSpCas9	negative selection	6654554
23680141	23680164	16	+	27260156	HS294T	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.1683199757621938	[1455]	[141,117,306,488]	-9	hSpCas9	negative selection	6654555
23683937	23683960	16	-	27260156	HS294T	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-1.0428641976333695	[1460]	[125,183,330,511]	-9	hSpCas9	negative selection	6718804
23680929	23680952	16	+	27260156	HS294T	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.49529784917534236	[252]	[60,57,77,83]	-6	hSpCas9	negative selection	6718805
23682105	23682128	16	+	27260156	HS294T	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.5618000570697603	[581]	[143,162,178,117]	-7	hSpCas9	negative selection	6718806
23680932	23680955	16	-	27260156	HCC44	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	0.011042955458931969	[1611]	[1776,1632,2527,1547]	0	hSpCas9	negative selection	6775804
23680143	23680166	16	-	27260156	HCC44	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-2.036585329681207	[1002]	[319,286,296,207]	-9	hSpCas9	negative selection	6775805
23680141	23680164	16	+	27260156	HCC44	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.8898471685393667	[1455]	[386,329,619,476]	-9	hSpCas9	negative selection	6775806
23683937	23683960	16	-	27260156	HCC44	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-1.8205077228539135	[1460]	[493,473,301,566]	-9	hSpCas9	negative selection	6840055
23680929	23680952	16	+	27260156	HCC44	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-1.1090762524888067	[252]	[141,110,187,102]	-8	hSpCas9	negative selection	6840056
23682105	23682128	16	+	27260156	HCC44	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.7998953491958056	[581]	[501,307,504,241]	-8	hSpCas9	negative selection	6840057
23680932	23680955	16	-	27260156	G402	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.05076582103264715	[1611]	[2056,1672,1902,1961]	0	hSpCas9	negative selection	6897055
23680143	23680166	16	-	27260156	G402	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-1.9910049550208986	[1002]	[364,335,332,210]	-9	hSpCas9	negative selection	6897056
23680141	23680164	16	+	27260156	G402	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.5571389134531493	[1455]	[602,603,696,512]	-9	hSpCas9	negative selection	6897057
23683937	23683960	16	-	27260156	G402	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-0.22978949920760194	[1460]	[2725,1315,1135,1080]	-3	hSpCas9	negative selection	6961306
23680929	23680952	16	+	27260156	G402	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.16027823813851705	[252]	[394,364,84,280]	-2	hSpCas9	negative selection	6961307
23682105	23682128	16	+	27260156	G402	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-1.1261807122871805	[581]	[335,235,325,394]	-8	hSpCas9	negative selection	6961308
23680932	23680955	16	-	27260156	L33	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.0033139239269199816	[1611]	[1501,660,1024,1688]	0	hSpCas9	negative selection	7018306
23680143	23680166	16	-	27260156	L33	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-0.38913693456691023	[1002]	[688,358,417,833]	-7	hSpCas9	negative selection	7018307
23680141	23680164	16	+	27260156	L33	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-0.5507095097962944	[1455]	[1020,398,596,1029]	-8	hSpCas9	negative selection	7018308
23683937	23683960	16	-	27260156	L33	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-0.044978235428384084	[1460]	[1383,629,853,1384]	-1	hSpCas9	negative selection	7082557
23680929	23680952	16	+	27260156	L33	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	0.02302718558767025	[252]	[287,77,191,243]	0	hSpCas9	negative selection	7082558
23682105	23682128	16	+	27260156	L33	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-1.0930047449993494	[581]	[213,120,163,321]	-9	hSpCas9	negative selection	7082559
23680932	23680955	16	-	27260156	K562	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	0.30777088554470944	[1611]	[1462,1505,2228,1830]	4	hSpCas9	negative selection	7139557
23680143	23680166	16	-	27260156	K562	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-2.7754530562980193	[1002]	[138,75,187,115]	-9	hSpCas9	negative selection	7139558
23680141	23680164	16	+	27260156	K562	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.970944455218672	[1455]	[316,320,314,358]	-9	hSpCas9	negative selection	7139559
23683937	23683960	16	-	27260156	K562	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-0.7480049470357099	[1460]	[973,602,928,605]	-7	hSpCas9	negative selection	7203808
23680929	23680952	16	+	27260156	K562	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.14221973832952162	[252]	[149,142,182,315]	-2	hSpCas9	negative selection	7203809
23682105	23682128	16	+	27260156	K562	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.6965424999607861	[581]	[245,427,287,311]	-7	hSpCas9	negative selection	7203810
23680932	23680955	16	-	27260156	HT29	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.2331287099164161	[1611]	[1708,1635,1760,1563]	-4	hSpCas9	negative selection	7260808
23680143	23680166	16	-	27260156	HT29	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-1.9066541204160738	[1002]	[224,511,291,282]	-9	hSpCas9	negative selection	7260809
23680141	23680164	16	+	27260156	HT29	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-2.383769523871043	[1455]	[410,241,338,356]	-9	hSpCas9	negative selection	7260810
23683937	23683960	16	-	27260156	HT29	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-1.7353968901495478	[1460]	[538,637,526,445]	-9	hSpCas9	negative selection	7325059
23680929	23680952	16	+	27260156	HT29	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.36553134019281064	[252]	[150,388,222,200]	-6	hSpCas9	negative selection	7325060
23682105	23682128	16	+	27260156	HT29	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.9134890657546983	[581]	[395,432,335,344]	-8	hSpCas9	negative selection	7325061
23680932	23680955	16	-	27260156	MHHES1	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.5283988691704158	[1611]	[1472,1552,1040,1043]	-7	hSpCas9	negative selection	7382059
23680143	23680166	16	-	27260156	MHHES1	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-0.8421120791171126	[1002]	[815,639,734,394]	-9	hSpCas9	negative selection	7382060
23680141	23680164	16	+	27260156	MHHES1	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-0.9951747578200041	[1455]	[917,808,1034,578]	-9	hSpCas9	negative selection	7382061
23683937	23683960	16	-	27260156	MHHES1	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-0.8578344934399614	[1460]	[1164,1005,750,762]	-9	hSpCas9	negative selection	7446310
23680929	23680952	16	+	27260156	MHHES1	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.41727470895476904	[252]	[203,237,139,256]	-7	hSpCas9	negative selection	7446311
23682105	23682128	16	+	27260156	MHHES1	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.7858981753729088	[581]	[519,226,298,449]	-9	hSpCas9	negative selection	7446312
23680932	23680955	16	-	27260156	MEWO	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	0.05187711248745419	[1611]	[1590,1570,1532]	1	hSpCas9	negative selection	7503310
23680143	23680166	16	-	27260156	MEWO	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-1.0174643945421513	[1002]	[495,422,477]	-9	hSpCas9	negative selection	7503311
23680141	23680164	16	+	27260156	MEWO	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.0149349110462103	[1455]	[607,729,670]	-9	hSpCas9	negative selection	7503312
23683937	23683960	16	-	27260156	MEWO	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-0.6486149271430733	[1460]	[1000,981,656]	-8	hSpCas9	negative selection	7567561
23680929	23680952	16	+	27260156	MEWO	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.9071330040743777	[252]	[116,92,166]	-9	hSpCas9	negative selection	7567562
23682105	23682128	16	+	27260156	MEWO	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.8897176150490604	[581]	[367,277,249]	-9	hSpCas9	negative selection	7567563
23680932	23680955	16	-	27260156	LNCAPCLONEFGC	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	0.2086832052597647	[1611]	[1814,1423,2099,1485]	3	hSpCas9	negative selection	7624561
23680143	23680166	16	-	27260156	LNCAPCLONEFGC	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-1.3635257138623436	[1002]	[256,423,397,336]	-9	hSpCas9	negative selection	7624562
23680141	23680164	16	+	27260156	LNCAPCLONEFGC	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.620431403529493	[1455]	[450,415,428,419]	-9	hSpCas9	negative selection	7624563
23683937	23683960	16	-	27260156	LNCAPCLONEFGC	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-0.9439298073343847	[1460]	[756,621,725,654]	-8	hSpCas9	negative selection	7688812
23680929	23680952	16	+	27260156	LNCAPCLONEFGC	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.6967926501740214	[252]	[184,125,190,70]	-8	hSpCas9	negative selection	7688813
23682105	23682128	16	+	27260156	LNCAPCLONEFGC	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.8715520318907266	[581]	[279,267,362,253]	-8	hSpCas9	negative selection	7688814
23680932	23680955	16	-	27260156	PANC0327	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.050521155908851645	[1611]	[1596,967,1293,1741]	0	hSpCas9	negative selection	7745812
23680143	23680166	16	-	27260156	PANC0327	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-2.681073112125384	[1002]	[134,95,204,124]	-9	hSpCas9	negative selection	7745813
23680141	23680164	16	+	27260156	PANC0327	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.350718106167316	[1455]	[797,451,309,498]	-9	hSpCas9	negative selection	7745814
23683937	23683960	16	-	27260156	PANC0327	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-1.06405235746452	[1460]	[608,565,711,601]	-8	hSpCas9	negative selection	7810063
23680929	23680952	16	+	27260156	PANC0327	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.17155566630952768	[252]	[219,220,175,179]	-3	hSpCas9	negative selection	7810064
23682105	23682128	16	+	27260156	PANC0327	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.9620628281712447	[581]	[180,194,466,220]	-8	hSpCas9	negative selection	7810065
23680932	23680955	16	-	27260156	NCIH2009	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.14944597024296313	[1611]	[2458,2140,1570]	-2	hSpCas9	negative selection	7867063
23680143	23680166	16	-	27260156	NCIH2009	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-1.7191734275027977	[1002]	[451,334,495]	-9	hSpCas9	negative selection	7867064
23680141	23680164	16	+	27260156	NCIH2009	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.9218526508941711	[1455]	[892,376,412]	-9	hSpCas9	negative selection	7867065
23683937	23683960	16	-	27260156	NCIH2009	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-1.6755159281161829	[1460]	[851,587,518]	-9	hSpCas9	negative selection	7931314
23680929	23680952	16	+	27260156	NCIH2009	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.6622558664470337	[252]	[184,229,246]	-7	hSpCas9	negative selection	7931315
23682105	23682128	16	+	27260156	NCIH2009	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-1.6743567597246045	[581]	[272,169,325]	-9	hSpCas9	negative selection	7931316
23680932	23680955	16	-	27260156	NCIH1373	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.33426180113902393	[1611]	[1811,1192,1196,426]	-3	hSpCas9	negative selection	7988314
23680143	23680166	16	-	27260156	NCIH1373	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-1.0077792278990294	[1002]	[460,749,544,113]	-7	hSpCas9	negative selection	7988315
23680141	23680164	16	+	27260156	NCIH1373	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.9051570982774078	[1455]	[542,298,550,97]	-9	hSpCas9	negative selection	7988316
23683937	23683960	16	-	27260156	NCIH1373	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-1.7915696022316925	[1460]	[512,380,569,114]	-9	hSpCas9	negative selection	8052565
23680929	23680952	16	+	27260156	NCIH1373	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-1.2202529291251727	[252]	[225,104,45,33]	-8	hSpCas9	negative selection	8052566
23682105	23682128	16	+	27260156	NCIH1373	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-1.3648468718082514	[581]	[341,193,279,55]	-8	hSpCas9	negative selection	8052567
23680932	23680955	16	-	27260156	PATU8902	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	0.0541972757444269	[1611]	[2141,2433,2004,2876]	0	hSpCas9	negative selection	8109565
23680143	23680166	16	-	27260156	PATU8902	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-2.610160696649737	[1002]	[410,235,83,215]	-9	hSpCas9	negative selection	8109566
23680141	23680164	16	+	27260156	PATU8902	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-2.864089060000784	[1455]	[359,342,68,408]	-9	hSpCas9	negative selection	8109567
23683937	23683960	16	-	27260156	PATU8902	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-3.170482986529852	[1460]	[177,170,117,495]	-9	hSpCas9	negative selection	8173816
23680929	23680952	16	+	27260156	PATU8902	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-1.4997191592813626	[252]	[131,227,69,75]	-8	hSpCas9	negative selection	8173817
23682105	23682128	16	+	27260156	PATU8902	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-1.4594852769075513	[581]	[206,460,216,315]	-8	hSpCas9	negative selection	8173818
23680932	23680955	16	-	27260156	PANC1	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.3878625230893047	[1611]	[934,1546,1200,696]	-6	hSpCas9	negative selection	8230816
23680143	23680166	16	-	27260156	PANC1	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-2.2254969983591697	[1002]	[202,227,107,199]	-9	hSpCas9	negative selection	8230817
23680141	23680164	16	+	27260156	PANC1	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-2.3894202107403126	[1455]	[205,400,250,142]	-9	hSpCas9	negative selection	8230818
23683937	23683960	16	-	27260156	PANC1	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-1.6359140272194874	[1460]	[375,467,394,385]	-9	hSpCas9	negative selection	8295067
23680929	23680952	16	+	27260156	PANC1	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.7529239766573717	[252]	[181,176,82,86]	-8	hSpCas9	negative selection	8295068
23682105	23682128	16	+	27260156	PANC1	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.9675868376419388	[581]	[290,326,274,155]	-8	hSpCas9	negative selection	8295069
23680932	23680955	16	-	27260156	PANC0813	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.21957513516808969	[1611]	[1584,1342,1911,1657]	-4	hSpCas9	negative selection	8352067
23680143	23680166	16	-	27260156	PANC0813	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-0.9493094313227171	[1002]	[745,614,505,585]	-8	hSpCas9	negative selection	8352068
23680141	23680164	16	+	27260156	PANC0813	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.1538320450471027	[1455]	[696,708,886,773]	-9	hSpCas9	negative selection	8352069
23683937	23683960	16	-	27260156	PANC0813	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-1.3659474949125765	[1460]	[741,611,782,539]	-9	hSpCas9	negative selection	8416318
23680929	23680952	16	+	27260156	PANC0813	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.7688537150443857	[252]	[189,161,192,154]	-8	hSpCas9	negative selection	8416319
23682105	23682128	16	+	27260156	PANC0813	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-1.0071576559710849	[581]	[299,302,522,236]	-8	hSpCas9	negative selection	8416320
23680932	23680955	16	-	27260156	RDES	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.27106314872074244	[1611]	[1327,1498,1523,1839]	-4	hSpCas9	negative selection	8473318
23680143	23680166	16	-	27260156	RDES	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-1.498132533580471	[1002]	[343,431,364,503]	-9	hSpCas9	negative selection	8473319
23680141	23680164	16	+	27260156	RDES	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.6306187135912675	[1455]	[337,551,592,740]	-9	hSpCas9	negative selection	8473320
23683937	23683960	16	-	27260156	RDES	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-1.3244835853337271	[1460]	[564,629,825,674]	-9	hSpCas9	negative selection	8537569
23680929	23680952	16	+	27260156	RDES	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-1.0759360339588135	[252]	[87,160,163,145]	-9	hSpCas9	negative selection	8537570
23682105	23682128	16	+	27260156	RDES	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.9250608853339854	[581]	[279,343,319,491]	-9	hSpCas9	negative selection	8537571
23680932	23680955	16	-	27260156	PC3	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	0.05078191912633456	[1611]	[981,1596,2596,2008]	1	hSpCas9	negative selection	8594569
23680143	23680166	16	-	27260156	PC3	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-0.722542599379023	[1002]	[334,686,1164,510]	-9	hSpCas9	negative selection	8594570
23680141	23680164	16	+	27260156	PC3	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-0.8818406019610989	[1455]	[515,585,1371,963]	-9	hSpCas9	negative selection	8594571
23683937	23683960	16	-	27260156	PC3	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-0.14592565399205482	[1460]	[773,1335,2008,1539]	-3	hSpCas9	negative selection	8658820
23680929	23680952	16	+	27260156	PC3	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.30498766085319007	[252]	[140,187,420,155]	-6	hSpCas9	negative selection	8658821
23682105	23682128	16	+	27260156	PC3	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.7104437031162956	[581]	[240,308,587,387]	-9	hSpCas9	negative selection	8658822
23680932	23680955	16	-	27260156	PATU8988T	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.19754776017824405	[1611]	[1296,1624,1126,1416]	-3	hSpCas9	negative selection	8715820
23680143	23680166	16	-	27260156	PATU8988T	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-1.57890888681621	[1002]	[241,377,427,246]	-9	hSpCas9	negative selection	8715821
23680141	23680164	16	+	27260156	PATU8988T	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.2866900585433052	[1455]	[963,562,426,333]	-9	hSpCas9	negative selection	8715822
23683937	23683960	16	-	27260156	PATU8988T	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-1.2287827203641295	[1460]	[388,703,586,750]	-9	hSpCas9	negative selection	8780071
23680929	23680952	16	+	27260156	PATU8988T	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.7484387636017711	[252]	[135,133,220,83]	-8	hSpCas9	negative selection	8780072
23682105	23682128	16	+	27260156	PATU8988T	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.4169490994570704	[581]	[253,372,652,394]	-6	hSpCas9	negative selection	8780073
23680932	23680955	16	-	27260156	T47D	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	0.03329429520412819	[1611]	[1826,1799,1986,2086]	0	hSpCas9	negative selection	8837071
23680143	23680166	16	-	27260156	T47D	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-1.0807582425237683	[1002]	[579,560,525,541]	-9	hSpCas9	negative selection	8837072
23680141	23680164	16	+	27260156	T47D	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.499318345842478	[1455]	[592,583,597,626]	-9	hSpCas9	negative selection	8837073
23683937	23683960	16	-	27260156	T47D	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-1.0634176177195493	[1460]	[954,734,715,861]	-9	hSpCas9	negative selection	8901322
23680929	23680952	16	+	27260156	T47D	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.19763416441801862	[252]	[254,203,226,349]	-4	hSpCas9	negative selection	8901323
23682105	23682128	16	+	27260156	T47D	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.5972409452128256	[581]	[483,448,436,421]	-8	hSpCas9	negative selection	8901324
23680932	23680955	16	-	27260156	SU8686	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.08079648858135613	[1611]	[1398,1380,1626,1687]	-1	hSpCas9	negative selection	8958322
23680143	23680166	16	-	27260156	SU8686	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-1.9191042631162851	[1002]	[225,223,307,309]	-9	hSpCas9	negative selection	8958323
23680141	23680164	16	+	27260156	SU8686	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.7988026963079218	[1455]	[359,393,453,466]	-9	hSpCas9	negative selection	8958324
23683937	23683960	16	-	27260156	SU8686	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-1.4540716645731906	[1460]	[578,399,561,591]	-9	hSpCas9	negative selection	9022573
23680929	23680952	16	+	27260156	SU8686	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.19423035102506225	[252]	[274,175,185,239]	-3	hSpCas9	negative selection	9022574
23682105	23682128	16	+	27260156	SU8686	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-1.2271222913130688	[581]	[203,198,279,325]	-9	hSpCas9	negative selection	9022575
23680932	23680955	16	-	27260156	SKES1	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.3168372688979084	[1611]	[1559,1221,1185,1220]	-6	hSpCas9	negative selection	9079573
23680143	23680166	16	-	27260156	SKES1	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-0.5592579747697441	[1002]	[873,591,792,487]	-8	hSpCas9	negative selection	9079574
23680141	23680164	16	+	27260156	SKES1	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.270641711672458	[1455]	[630,697,532,560]	-9	hSpCas9	negative selection	9079575
23683937	23683960	16	-	27260156	SKES1	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-0.6753997436207956	[1460]	[978,867,1095,721]	-9	hSpCas9	negative selection	9143824
23680929	23680952	16	+	27260156	SKES1	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.43959596852332017	[252]	[215,228,94,209]	-7	hSpCas9	negative selection	9143825
23682105	23682128	16	+	27260156	SKES1	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.932164398253247	[581]	[395,307,353,182]	-9	hSpCas9	negative selection	9143826
23680932	23680955	16	-	27260156	TOV112D	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	0.01869106762159234	[1611]	[1703,1698,1236,1912]	0	hSpCas9	negative selection	9200824
23680143	23680166	16	-	27260156	TOV112D	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-0.3004133300378605	[1002]	[663,903,760,937]	-5	hSpCas9	negative selection	9200825
23680141	23680164	16	+	27260156	TOV112D	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-1.0743421667956903	[1455]	[708,720,571,772]	-9	hSpCas9	negative selection	9200826
23683937	23683960	16	-	27260156	TOV112D	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-0.47350604601970203	[1460]	[1085,1166,1000,991]	-7	hSpCas9	negative selection	9265075
23680929	23680952	16	+	27260156	TOV112D	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.299546953049999	[252]	[218,269,214,137]	-5	hSpCas9	negative selection	9265076
23682105	23682128	16	+	27260156	TOV112D	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.316308411780487	[581]	[516,811,397,239]	-6	hSpCas9	negative selection	9265077
23680932	23680955	16	-	27260156	TC71	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.051355089787953334	[1611]	[1465,1746,1605,1869]	-1	hSpCas9	negative selection	9322075
23680143	23680166	16	-	27260156	TC71	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-0.3516562179468362	[1002]	[883,896,732,859]	-7	hSpCas9	negative selection	9322076
23680141	23680164	16	+	27260156	TC71	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-0.6954166273820308	[1455]	[744,1136,1006,969]	-9	hSpCas9	negative selection	9322077
23683937	23683960	16	-	27260156	TC71	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-0.2894065931765999	[1460]	[1218,1226,1388,1288]	-7	hSpCas9	negative selection	9386326
23680929	23680952	16	+	27260156	TC71	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.42172994724739277	[252]	[200,203,190,214]	-8	hSpCas9	negative selection	9386327
23682105	23682128	16	+	27260156	TC71	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.5843016687188857	[581]	[378,414,373,503]	-9	hSpCas9	negative selection	9386328
23680932	23680955	16	-	27260156	TC32	viability	CTCCCCGTCATATTCGACTTTGG	PLK1	ENSG00000166851	-0.27258811668232363	[1611]	[1200,1015,1532,1338]	-5	hSpCas9	negative selection	9443326
23680143	23680166	16	-	27260156	TC32	viability	AGCCAAGCACAATTTGCCGTAGG	PLK1	ENSG00000166851	-0.840627124897848	[1002]	[506,361,581,707]	-9	hSpCas9	negative selection	9443327
23680141	23680164	16	+	27260156	TC32	viability	TACCTACGGCAAATTGTGCTTGG	PLK1	ENSG00000166851	-0.9555290945066885	[1455]	[589,575,1022,709]	-9	hSpCas9	negative selection	9443328
23683937	23683960	16	-	27260156	TC32	viability	GTCATTAAGCAGCTCGTTAATGG	PLK1	ENSG00000166851	-0.6847703235048848	[1460]	[752,636,1207,928]	-8	hSpCas9	negative selection	9507577
23680929	23680952	16	+	27260156	TC32	viability	CAACCAAAGTCGAATATGACGGG	PLK1	ENSG00000166851	-0.2471595556736068	[252]	[134,164,360,176]	-4	hSpCas9	negative selection	9507578
23682105	23682128	16	+	27260156	TC32	viability	GCCTAAAAGAGACCTACCTCCGG	PLK1	ENSG00000166851	-0.693063907379814	[581]	[290,121,613,451]	-8	hSpCas9	negative selection	9507579
23679195	23679218	16	+	27869803	HPAFII	viability after 27 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	-2.706424669281972	[271]	[40,5,NaN]	-9	hSpCas9	negative selection	9556256
23679331	23679354	16	-	27869803	HPAFII	viability after 27 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-7.2769906898735	[294]	[0,0,NaN]	-9	hSpCas9	negative selection	9556257
23680978	23681001	16	+	27869803	HPAFII	viability after 27 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-3.6180078080113085	[275]	[13,9,NaN]	-9	hSpCas9	negative selection	9556258
23684028	23684051	16	+	27869803	HPAFII	viability after 27 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	0.9588313883601433	[273]	[219,329,NaN]	7	hSpCas9	negative selection	9556259
23689242	23689265	16	+	27869803	HPAFII	viability after 27 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-5.977262312583957	[511]	[0,6,NaN]	-9	hSpCas9	negative selection	9556261
23679195	23679218	16	+	27869803	HPAFII	viability after 15 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	-2.278399725682391	[271]	[124,19,NaN]	-9	hSpCas9	negative selection	9638705
23679331	23679354	16	-	27869803	HPAFII	viability after 15 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-6.2789021263676235	[294]	[0,5,NaN]	-9	hSpCas9	negative selection	9638706
23680978	23681001	16	+	27869803	HPAFII	viability after 15 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-3.530807118644127	[275]	[0,40,NaN]	-9	hSpCas9	negative selection	9638707
23684028	23684051	16	+	27869803	HPAFII	viability after 15 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	0.3550614943239584	[273]	[515,289,NaN]	4	hSpCas9	negative selection	9638708
23689242	23689265	16	+	27869803	HPAFII	viability after 15 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-4.476627311525	[511]	[12,31,NaN]	-9	hSpCas9	negative selection	9638710
23679195	23679218	16	+	27869803	ASPC1	viability after 36 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	-0.6883626473969207	[729]	[102,311,72]	-6	hSpCas9	negative selection	9721154
23679331	23679354	16	-	27869803	ASPC1	viability after 36 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-3.545763919958244	[826]	[84,0,0]	-9	hSpCas9	negative selection	9721155
23680978	23681001	16	+	27869803	ASPC1	viability after 36 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-3.6094288382665414	[853]	[0,33,32]	-9	hSpCas9	negative selection	9721156
23684028	23684051	16	+	27869803	ASPC1	viability after 36 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	0.18947464609593292	[678]	[72,419,286]	1	hSpCas9	negative selection	9721157
23689242	23689265	16	+	27869803	ASPC1	viability after 36 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-3.3821723848092526	[1225]	[129,0,9]	-9	hSpCas9	negative selection	9721159
23679195	23679218	16	+	27869803	PATU8988S	viability after 35 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	-1.2584544593400022	[478]	[140,19,NaN]	-8	hSpCas9	negative selection	9803603
23679331	23679354	16	-	27869803	PATU8988S	viability after 35 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-5.881071852740388	[657]	[2,5,NaN]	-9	hSpCas9	negative selection	9803604
23680978	23681001	16	+	27869803	PATU8988S	viability after 35 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-2.7443910445845057	[690]	[54,27,NaN]	-9	hSpCas9	negative selection	9803605
23684028	23684051	16	+	27869803	PATU8988S	viability after 35 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	0.8502216549268234	[531]	[503,267,NaN]	8	hSpCas9	negative selection	9803606
23689242	23689265	16	+	27869803	PATU8988S	viability after 35 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-3.7881159533732762	[1027]	[16,42,NaN]	-9	hSpCas9	negative selection	9803608
23679195	23679218	16	+	27869803	PATU8988S	viability after 31 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	-2.1336817220068673	[478]	[61,19,NaN]	-9	hSpCas9	negative selection	9886052
23679331	23679354	16	-	27869803	PATU8988S	viability after 31 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-4.265522576165121	[657]	[21,2,NaN]	-9	hSpCas9	negative selection	9886053
23680978	23681001	16	+	27869803	PATU8988S	viability after 31 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-2.164970527822384	[690]	[60,61,NaN]	-9	hSpCas9	negative selection	9886054
23684028	23684051	16	+	27869803	PATU8988S	viability after 31 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	0.5149416465169229	[531]	[314,287,NaN]	6	hSpCas9	negative selection	9886055
23689242	23689265	16	+	27869803	PATU8988S	viability after 31 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-4.558405198283264	[1027]	[1,36,NaN]	-9	hSpCas9	negative selection	9886057
23679195	23679218	16	+	27869803	HPAFII	viability after 35 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	-3.9831140832470915	[271]	[11,4,NaN]	-9	hSpCas9	negative selection	9968501
23679331	23679354	16	-	27869803	HPAFII	viability after 35 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-7.222482591252529	[294]	[0,0,NaN]	-9	hSpCas9	negative selection	9968502
23680978	23681001	16	+	27869803	HPAFII	viability after 35 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-4.074630515898536	[275]	[4,11,NaN]	-9	hSpCas9	negative selection	9968503
23684028	23684051	16	+	27869803	HPAFII	viability after 35 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	0.7318751670867167	[273]	[148,321,NaN]	5	hSpCas9	negative selection	9968504
23689242	23689265	16	+	27869803	HPAFII	viability after 35 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-6.272984567134436	[511]	[0,5,NaN]	-9	hSpCas9	negative selection	9968506
23679195	23679218	16	+	27869803	HPAFII	viability after 31 days	TGCTGCTCAAGCCGCACCAGAGG	PLK1	ENSG00000166851	-4.310572123975841	[271]	[11,2,NaN]	-9	hSpCas9	negative selection	10050950
23679331	23679354	16	-	27869803	HPAFII	viability after 31 days	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-7.371199944573946	[294]	[0,0,NaN]	-9	hSpCas9	negative selection	10050951
23680978	23681001	16	+	27869803	HPAFII	viability after 31 days	TCCTAATTACATAGCTCCCGAGG	PLK1	ENSG00000166851	-3.8976328362522317	[275]	[7,12,NaN]	-9	hSpCas9	negative selection	10050952
23684028	23684051	16	+	27869803	HPAFII	viability after 31 days	TTCGATTGCTCCCAGCAGCCTGG	PLK1	ENSG00000166851	1.1852246957737032	[273]	[308,393,NaN]	8	hSpCas9	negative selection	10050953
23689242	23689265	16	+	27869803	HPAFII	viability after 31 days	TCAGCTCTGTGATAACAGCGTGG	PLK1	ENSG00000166851	-4.271464693229062	[511]	[0,29,NaN]	-9	hSpCas9	negative selection	10050955
23679063	23679086	16	+	28162770	P31FUJ	viability	TAGTGGACCCACGCAGCCGGCGG	PLK1	ENSG00000166851	-3.3880804298922893	[97]	[10]	-9	hSpCas9	negative selection	10213020
23683995	23684018	16	-	28162770	P31FUJ	viability	GAATGGTCAGGCAGGTGATGGGG	PLK1	ENSG00000166851	-1.703648612594003	[570]	[205]	-8	hSpCas9	negative selection	10213021
23679196	23679219	16	+	28162770	P31FUJ	viability	GCTGCTCAAGCCGCACCAGAGGG	PLK1	ENSG00000166851	-1.6670332689265335	[226]	[83]	-8	hSpCas9	negative selection	10213022
23681011	23681034	16	+	28162770	P31FUJ	viability	GAAAGGGCACAGTTTCGAGGTGG	PLK1	ENSG00000166851	-3.613623988355309	[124]	[11]	-9	hSpCas9	negative selection	10213023
23679259	23679282	16	-	28162770	P31FUJ	viability	GGAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-4.384805297859429	[159]	[8]	-9	hSpCas9	negative selection	10213024
23679331	23679354	16	-	28162770	P31FUJ	viability	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-4.277196323772832	[164]	[9]	-9	hSpCas9	negative selection	10213025
23680930	23680953	16	+	28162770	P31FUJ	viability	AACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-2.810878319550295	[208]	[34]	-9	hSpCas9	negative selection	10213026
23683863	23683886	16	+	28162770	P31FUJ	viability	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	-7.103166923997783	[350]	[2]	-9	hSpCas9	negative selection	10213027
23683929	23683952	16	-	28162770	P31FUJ	viability	GCAGCTCGTTAATGGTTGGGCGG	PLK1	ENSG00000166851	-2.5241812359421343	[513]	[104]	-8	hSpCas9	negative selection	10213028
23679063	23679086	16	+	28162770	TF1	viability	TAGTGGACCCACGCAGCCGGCGG	PLK1	ENSG00000166851	NaN	[NaN]	[0]	1	hSpCas9	negative selection	10382386
23683995	23684018	16	-	28162770	TF1	viability	GAATGGTCAGGCAGGTGATGGGG	PLK1	ENSG00000166851	NaN	[NaN]	[75]	1	hSpCas9	negative selection	10382387
23679196	23679219	16	+	28162770	TF1	viability	GCTGCTCAAGCCGCACCAGAGGG	PLK1	ENSG00000166851	NaN	[NaN]	[77]	1	hSpCas9	negative selection	10382388
23681011	23681034	16	+	28162770	TF1	viability	GAAAGGGCACAGTTTCGAGGTGG	PLK1	ENSG00000166851	NaN	[NaN]	[30]	1	hSpCas9	negative selection	10382389
23679259	23679282	16	-	28162770	TF1	viability	GGAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	NaN	[NaN]	[17]	1	hSpCas9	negative selection	10382390
23679331	23679354	16	-	28162770	TF1	viability	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	NaN	[NaN]	[25]	1	hSpCas9	negative selection	10382391
23680930	23680953	16	+	28162770	TF1	viability	AACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	NaN	[NaN]	[17]	1	hSpCas9	negative selection	10382392
23683863	23683886	16	+	28162770	TF1	viability	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	NaN	[NaN]	[21]	1	hSpCas9	negative selection	10382393
23683929	23683952	16	-	28162770	TF1	viability	GCAGCTCGTTAATGGTTGGGCGG	PLK1	ENSG00000166851	NaN	[NaN]	[37]	1	hSpCas9	negative selection	10382394
23679063	23679086	16	+	28162770	SKM1	viability	TAGTGGACCCACGCAGCCGGCGG	PLK1	ENSG00000166851	-1.3875988738762306	[36]	[24]	-7	hSpCas9	negative selection	10551752
23683995	23684018	16	-	28162770	SKM1	viability	GAATGGTCAGGCAGGTGATGGGG	PLK1	ENSG00000166851	-2.0630097975258	[129]	[54]	-8	hSpCas9	negative selection	10551753
23679196	23679219	16	+	28162770	SKM1	viability	GCTGCTCAAGCCGCACCAGAGGG	PLK1	ENSG00000166851	-2.406964198743162	[50]	[16]	-8	hSpCas9	negative selection	10551754
23681011	23681034	16	+	28162770	SKM1	viability	GAAAGGGCACAGTTTCGAGGTGG	PLK1	ENSG00000166851	-2.4069641987431614	[38]	[12]	-8	hSpCas9	negative selection	10551755
23679259	23679282	16	-	28162770	SKM1	viability	GGAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-2.1332033863163096	[66]	[26]	-8	hSpCas9	negative selection	10551756
23679331	23679354	16	-	28162770	SKM1	viability	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-3.6293566200796095	[20]	[2]	-9	hSpCas9	negative selection	10551757
23680930	23680953	16	+	28162770	SKM1	viability	AACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-1.8220016980220055	[33]	[16]	-8	hSpCas9	negative selection	10551758
23683863	23683886	16	+	28162770	SKM1	viability	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	-3.102109617214741	[67]	[13]	-9	hSpCas9	negative selection	10551759
23683929	23683952	16	-	28162770	SKM1	viability	GCAGCTCGTTAATGGTTGGGCGG	PLK1	ENSG00000166851	-2.1226611761557166	[100]	[40]	-8	hSpCas9	negative selection	10551760
23679063	23679086	16	+	28162770	SKM1	viability	TAGTGGACCCACGCAGCCGGCGG	PLK1	ENSG00000166851	-1.3875988738762306	[36]	[24]	-7	hSpCas9	negative selection	10721118
23683995	23684018	16	-	28162770	SKM1	viability	GAATGGTCAGGCAGGTGATGGGG	PLK1	ENSG00000166851	-2.0630097975258	[129]	[54]	-8	hSpCas9	negative selection	10721119
23679196	23679219	16	+	28162770	SKM1	viability	GCTGCTCAAGCCGCACCAGAGGG	PLK1	ENSG00000166851	-2.406964198743162	[50]	[16]	-8	hSpCas9	negative selection	10721120
23681011	23681034	16	+	28162770	SKM1	viability	GAAAGGGCACAGTTTCGAGGTGG	PLK1	ENSG00000166851	-2.4069641987431614	[38]	[12]	-8	hSpCas9	negative selection	10721121
23679259	23679282	16	-	28162770	SKM1	viability	GGAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-2.1332033863163096	[66]	[26]	-8	hSpCas9	negative selection	10721122
23679331	23679354	16	-	28162770	SKM1	viability	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-3.6293566200796095	[20]	[2]	-9	hSpCas9	negative selection	10721123
23680930	23680953	16	+	28162770	SKM1	viability	AACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-1.8220016980220055	[33]	[16]	-8	hSpCas9	negative selection	10721124
23683863	23683886	16	+	28162770	SKM1	viability	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	-3.102109617214741	[67]	[13]	-9	hSpCas9	negative selection	10721125
23683929	23683952	16	-	28162770	SKM1	viability	GCAGCTCGTTAATGGTTGGGCGG	PLK1	ENSG00000166851	-2.1226611761557166	[100]	[40]	-8	hSpCas9	negative selection	10721126
23679063	23679086	16	+	28162770	PL21	viability	TAGTGGACCCACGCAGCCGGCGG	PLK1	ENSG00000166851	-5.085262604372929	[77]	[0]	-9	hSpCas9	negative selection	10890484
23683995	23684018	16	-	28162770	PL21	viability	GAATGGTCAGGCAGGTGATGGGG	PLK1	ENSG00000166851	-0.3414302907184553	[392]	[134]	-2	hSpCas9	negative selection	10890485
23679196	23679219	16	+	28162770	PL21	viability	GCTGCTCAAGCCGCACCAGAGGG	PLK1	ENSG00000166851	-4.028679076006561	[149]	[3]	-9	hSpCas9	negative selection	10890486
23681011	23681034	16	+	28162770	PL21	viability	GAAAGGGCACAGTTTCGAGGTGG	PLK1	ENSG00000166851	-1.754056695897555	[123]	[15]	-8	hSpCas9	negative selection	10890487
23679259	23679282	16	-	28162770	PL21	viability	GGAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-1.8983502489100432	[196]	[22]	-8	hSpCas9	negative selection	10890488
23679331	23679354	16	-	28162770	PL21	viability	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-5.670225105094085	[116]	[0]	-9	hSpCas9	negative selection	10890489
23680930	23680953	16	+	28162770	PL21	viability	AACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-1.302360726039863	[152]	[26]	-7	hSpCas9	negative selection	10890490
23683863	23683886	16	+	28162770	PL21	viability	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	-2.0222528068471277	[251]	[26]	-8	hSpCas9	negative selection	10890491
23683929	23683952	16	-	28162770	PL21	viability	GCAGCTCGTTAATGGTTGGGCGG	PLK1	ENSG00000166851	-2.203974235753287	[306]	[28]	-8	hSpCas9	negative selection	10890492
23679063	23679086	16	+	28162770	P31FUJ	viability	TAGTGGACCCACGCAGCCGGCGG	PLK1	ENSG00000166851	-3.3880804298922893	[97]	[10]	-9	hSpCas9	negative selection	11059850
23683995	23684018	16	-	28162770	P31FUJ	viability	GAATGGTCAGGCAGGTGATGGGG	PLK1	ENSG00000166851	-1.703648612594003	[570]	[205]	-8	hSpCas9	negative selection	11059851
23679196	23679219	16	+	28162770	P31FUJ	viability	GCTGCTCAAGCCGCACCAGAGGG	PLK1	ENSG00000166851	-1.6670332689265335	[226]	[83]	-8	hSpCas9	negative selection	11059852
23681011	23681034	16	+	28162770	P31FUJ	viability	GAAAGGGCACAGTTTCGAGGTGG	PLK1	ENSG00000166851	-3.613623988355309	[124]	[11]	-9	hSpCas9	negative selection	11059853
23679259	23679282	16	-	28162770	P31FUJ	viability	GGAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-4.384805297859429	[159]	[8]	-9	hSpCas9	negative selection	11059854
23679331	23679354	16	-	28162770	P31FUJ	viability	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-4.277196323772832	[164]	[9]	-9	hSpCas9	negative selection	11059855
23680930	23680953	16	+	28162770	P31FUJ	viability	AACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-2.810878319550295	[208]	[34]	-9	hSpCas9	negative selection	11059856
23683863	23683886	16	+	28162770	P31FUJ	viability	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	-7.103166923997783	[350]	[2]	-9	hSpCas9	negative selection	11059857
23683929	23683952	16	-	28162770	P31FUJ	viability	GCAGCTCGTTAATGGTTGGGCGG	PLK1	ENSG00000166851	-2.5241812359421343	[513]	[104]	-8	hSpCas9	negative selection	11059858
23679063	23679086	16	+	28162770	OCIAML5	viability	TAGTGGACCCACGCAGCCGGCGG	PLK1	ENSG00000166851	-1.895135292755883	[67]	[32]	-7	hSpCas9	negative selection	11229216
23683995	23684018	16	-	28162770	OCIAML5	viability	GAATGGTCAGGCAGGTGATGGGG	PLK1	ENSG00000166851	-1.9984560578455204	[227]	[102]	-8	hSpCas9	negative selection	11229217
23679196	23679219	16	+	28162770	OCIAML5	viability	GCTGCTCAAGCCGCACCAGAGGG	PLK1	ENSG00000166851	-1.7589571664725154	[104]	[55]	-7	hSpCas9	negative selection	11229218
23681011	23681034	16	+	28162770	OCIAML5	viability	GAAAGGGCACAGTTTCGAGGTGG	PLK1	ENSG00000166851	-4.311498189501294	[54]	[4]	-9	hSpCas9	negative selection	11229219
23679259	23679282	16	-	28162770	OCIAML5	viability	GGAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-2.8915949350506343	[110]	[26]	-8	hSpCas9	negative selection	11229220
23679331	23679354	16	-	28162770	OCIAML5	viability	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-6.8062628812508725	[61]	[0]	-9	hSpCas9	negative selection	11229221
23680930	23680953	16	+	28162770	OCIAML5	viability	AACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-1.3209105138386346	[172]	[124]	-6	hSpCas9	negative selection	11229222
23683863	23683886	16	+	28162770	OCIAML5	viability	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	-5.861055354091251	[160]	[4]	-9	hSpCas9	negative selection	11229223
23683929	23683952	16	-	28162770	OCIAML5	viability	GCAGCTCGTTAATGGTTGGGCGG	PLK1	ENSG00000166851	-2.115100976697791	[203]	[84]	-8	hSpCas9	negative selection	11229224
23679063	23679086	16	+	28162770	EOL1	viability	TAGTGGACCCACGCAGCCGGCGG	PLK1	ENSG00000166851	-1.5436010641678715	[165]	[29]	-7	hSpCas9	negative selection	11398582
23683995	23684018	16	-	28162770	EOL1	viability	GAATGGTCAGGCAGGTGATGGGG	PLK1	ENSG00000166851	-0.566022358875667	[561]	[199]	-4	hSpCas9	negative selection	11398583
23679196	23679219	16	+	28162770	EOL1	viability	GCTGCTCAAGCCGCACCAGAGGG	PLK1	ENSG00000166851	-1.722571205213191	[331]	[52]	-8	hSpCas9	negative selection	11398584
23681011	23681034	16	+	28162770	EOL1	viability	GAAAGGGCACAGTTTCGAGGTGG	PLK1	ENSG00000166851	-0.7128821490447572	[195]	[62]	-5	hSpCas9	negative selection	11398585
23679259	23679282	16	-	28162770	EOL1	viability	GGAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-1.716371135124637	[367]	[58]	-8	hSpCas9	negative selection	11398586
23679331	23679354	16	-	28162770	EOL1	viability	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-5.397380323316828	[159]	[1]	-9	hSpCas9	negative selection	11398587
23680930	23680953	16	+	28162770	EOL1	viability	AACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-1.7549323279349114	[204]	[31]	-8	hSpCas9	negative selection	11398588
23683863	23683886	16	+	28162770	EOL1	viability	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	-5.119846347787918	[329]	[4]	-9	hSpCas9	negative selection	11398589
23683929	23683952	16	-	28162770	EOL1	viability	GCAGCTCGTTAATGGTTGGGCGG	PLK1	ENSG00000166851	-2.9823428240379837	[464]	[30]	-9	hSpCas9	negative selection	11398590
23679063	23679086	16	+	28162770	MOLM13	viability	TAGTGGACCCACGCAGCCGGCGG	PLK1	ENSG00000166851	-0.5207953052275869	[126]	[63]	-3	hSpCas9	negative selection	11567948
23683995	23684018	16	-	28162770	MOLM13	viability	GAATGGTCAGGCAGGTGATGGGG	PLK1	ENSG00000166851	-2.9170485108685837	[584]	[55]	-8	hSpCas9	negative selection	11567949
23679196	23679219	16	+	28162770	MOLM13	viability	GCTGCTCAAGCCGCACCAGAGGG	PLK1	ENSG00000166851	-1.0066491294829267	[263]	[94]	-5	hSpCas9	negative selection	11567950
23681011	23681034	16	+	28162770	MOLM13	viability	GAAAGGGCACAGTTTCGAGGTGG	PLK1	ENSG00000166851	-1.675701472084271	[189]	[42]	-7	hSpCas9	negative selection	11567951
23679259	23679282	16	-	28162770	MOLM13	viability	GGAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-3.135451648491432	[315]	[25]	-8	hSpCas9	negative selection	11567952
23679331	23679354	16	-	28162770	MOLM13	viability	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-6.651051691178929	[138]	[0]	-9	hSpCas9	negative selection	11567953
23680930	23680953	16	+	28162770	MOLM13	viability	AACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-3.45335650704101	[302]	[19]	-8	hSpCas9	negative selection	11567954
23683863	23683886	16	+	28162770	MOLM13	viability	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	-8.253209807162607	[421]	[0]	-9	hSpCas9	negative selection	11567955
23683929	23683952	16	-	28162770	MOLM13	viability	GCAGCTCGTTAATGGTTGGGCGG	PLK1	ENSG00000166851	-4.289963579095451	[486]	[17]	-9	hSpCas9	negative selection	11567956
23679063	23679086	16	+	28162770	HEL	viability	TAGTGGACCCACGCAGCCGGCGG	PLK1	ENSG00000166851	-1.6267218429928698	[134]	[27]	-7	hSpCas9	negative selection	11737314
23683995	23684018	16	-	28162770	HEL	viability	GAATGGTCAGGCAGGTGATGGGG	PLK1	ENSG00000166851	-3.0192267383260996	[480]	[37]	-8	hSpCas9	negative selection	11737315
23679196	23679219	16	+	28162770	HEL	viability	GCTGCTCAAGCCGCACCAGAGGG	PLK1	ENSG00000166851	-2.9476780988129074	[264]	[21]	-8	hSpCas9	negative selection	11737316
23681011	23681034	16	+	28162770	HEL	viability	GAAAGGGCACAGTTTCGAGGTGG	PLK1	ENSG00000166851	-2.9321700040568763	[142]	[11]	-8	hSpCas9	negative selection	11737317
23679259	23679282	16	-	28162770	HEL	viability	GGAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-3.4552932509601697	[273]	[15]	-9	hSpCas9	negative selection	11737318
23679331	23679354	16	-	28162770	HEL	viability	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-6.202751218944019	[114]	[0]	-9	hSpCas9	negative selection	11737319
23680930	23680953	16	+	28162770	HEL	viability	AACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-4.8297489394623865	[221]	[4]	-9	hSpCas9	negative selection	11737320
23683863	23683886	16	+	28162770	HEL	viability	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	-5.947224349779166	[288]	[2]	-9	hSpCas9	negative selection	11737321
23683929	23683952	16	-	28162770	HEL	viability	GCAGCTCGTTAATGGTTGGGCGG	PLK1	ENSG00000166851	-3.552465577890313	[402]	[21]	-9	hSpCas9	negative selection	11737322
23679063	23679086	16	+	28162770	MV411	viability	TAGTGGACCCACGCAGCCGGCGG	PLK1	ENSG00000166851	-1.2057350773828395	[114]	[41]	-7	hSpCas9	negative selection	11906680
23683995	23684018	16	-	28162770	MV411	viability	GAATGGTCAGGCAGGTGATGGGG	PLK1	ENSG00000166851	-0.9760868400435927	[424]	[181]	-6	hSpCas9	negative selection	11906681
23679196	23679219	16	+	28162770	MV411	viability	GCTGCTCAAGCCGCACCAGAGGG	PLK1	ENSG00000166851	-2.2994569091048613	[186]	[31]	-8	hSpCas9	negative selection	11906682
23681011	23681034	16	+	28162770	MV411	viability	GAAAGGGCACAGTTTCGAGGTGG	PLK1	ENSG00000166851	-0.5246105025388761	[110]	[64]	-4	hSpCas9	negative selection	11906683
23679259	23679282	16	-	28162770	MV411	viability	GGAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-2.0904320879736082	[181]	[35]	-8	hSpCas9	negative selection	11906684
23679331	23679354	16	-	28162770	MV411	viability	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-4.5980525001616	[114]	[3]	-9	hSpCas9	negative selection	11906685
23680930	23680953	16	+	28162770	MV411	viability	AACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-0.9420402480809374	[129]	[56]	-6	hSpCas9	negative selection	11906686
23683863	23683886	16	+	28162770	MV411	viability	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	-5.313277403691703	[235]	[4]	-9	hSpCas9	negative selection	11906687
23683929	23683952	16	-	28162770	MV411	viability	GCAGCTCGTTAATGGTTGGGCGG	PLK1	ENSG00000166851	-3.0025407022255726	[351]	[36]	-9	hSpCas9	negative selection	11906688
23679063	23679086	16	+	28162770	MONOMAC1	viability	TAGTGGACCCACGCAGCCGGCGG	PLK1	ENSG00000166851	-3.213338659388654	[88]	[10]	-9	hSpCas9	negative selection	12076046
23683995	23684018	16	-	28162770	MONOMAC1	viability	GAATGGTCAGGCAGGTGATGGGG	PLK1	ENSG00000166851	-0.8140605570130086	[272]	[177]	-6	hSpCas9	negative selection	12076047
23679196	23679219	16	+	28162770	MONOMAC1	viability	GCTGCTCAAGCCGCACCAGAGGG	PLK1	ENSG00000166851	-1.4116308978355945	[122]	[52]	-8	hSpCas9	negative selection	12076048
23681011	23681034	16	+	28162770	MONOMAC1	viability	GAAAGGGCACAGTTTCGAGGTGG	PLK1	ENSG00000166851	-2.375374088318066	[85]	[18]	-9	hSpCas9	negative selection	12076049
23679259	23679282	16	-	28162770	MONOMAC1	viability	GGAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-1.0506473600780304	[102]	[56]	-7	hSpCas9	negative selection	12076050
23679331	23679354	16	-	28162770	MONOMAC1	viability	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-4.9696263509564815	[81]	[2]	-9	hSpCas9	negative selection	12076051
23680930	23680953	16	+	28162770	MONOMAC1	viability	AACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-0.4194292683960018	[83]	[71]	-4	hSpCas9	negative selection	12076052
23683863	23683886	16	+	28162770	MONOMAC1	viability	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	-1.97197029142478	[153]	[44]	-8	hSpCas9	negative selection	12076053
23683929	23683952	16	-	28162770	MONOMAC1	viability	GCAGCTCGTTAATGGTTGGGCGG	PLK1	ENSG00000166851	-2.5529122738702537	[214]	[41]	-9	hSpCas9	negative selection	12076054
23679063	23679086	16	+	28162770	OCIAML2	viability	TAGTGGACCCACGCAGCCGGCGG	PLK1	ENSG00000166851	-2.229621725738366	[21]	[25]	-8	hSpCas9	negative selection	12245412
23683995	23684018	16	-	28162770	OCIAML2	viability	GAATGGTCAGGCAGGTGATGGGG	PLK1	ENSG00000166851	-1.8654894425833746	[70]	[107]	-8	hSpCas9	negative selection	12245413
23679196	23679219	16	+	28162770	OCIAML2	viability	GCTGCTCAAGCCGCACCAGAGGG	PLK1	ENSG00000166851	-1.3551526078222254	[23]	[51]	-7	hSpCas9	negative selection	12245414
23681011	23681034	16	+	28162770	OCIAML2	viability	GAAAGGGCACAGTTTCGAGGTGG	PLK1	ENSG00000166851	-2.590924058959873	[24]	[22]	-8	hSpCas9	negative selection	12245415
23679259	23679282	16	-	28162770	OCIAML2	viability	GGAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-2.414046296875794	[49]	[51]	-8	hSpCas9	negative selection	12245416
23679331	23679354	16	-	28162770	OCIAML2	viability	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-5.409229280578018	[22]	[2]	-9	hSpCas9	negative selection	12245417
23680930	23680953	16	+	28162770	OCIAML2	viability	AACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-2.9251956887076425	[36]	[26]	-9	hSpCas9	negative selection	12245418
23683863	23683886	16	+	28162770	OCIAML2	viability	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	-6.640554826684474	[35]	[1]	-9	hSpCas9	negative selection	12245419
23683929	23683952	16	-	28162770	OCIAML2	viability	GCAGCTCGTTAATGGTTGGGCGG	PLK1	ENSG00000166851	-2.825724784064723	[54]	[42]	-9	hSpCas9	negative selection	12245420
23679063	23679086	16	+	28162770	OCIAML3	viability	TAGTGGACCCACGCAGCCGGCGG	PLK1	ENSG00000166851	1.33199177823206	[14]	[113]	9	hSpCas9	negative selection	12414778
23683995	23684018	16	-	28162770	OCIAML3	viability	GAATGGTCAGGCAGGTGATGGGG	PLK1	ENSG00000166851	1.904243227203662	[119]	[1355]	9	hSpCas9	negative selection	12414779
23679196	23679219	16	+	28162770	OCIAML3	viability	GCTGCTCAAGCCGCACCAGAGGG	PLK1	ENSG00000166851	-1.6264291180165404	[44]	[43]	-8	hSpCas9	negative selection	12414780
23681011	23681034	16	+	28162770	OCIAML3	viability	GAAAGGGCACAGTTTCGAGGTGG	PLK1	ENSG00000166851	-2.594007640324163	[33]	[16]	-9	hSpCas9	negative selection	12414781
23679259	23679282	16	-	28162770	OCIAML3	viability	GGAATCCTACGACGTGCTGGTGG	PLK1	ENSG00000166851	-1.749285865802074	[48]	[43]	-8	hSpCas9	negative selection	12414782
23679331	23679354	16	-	28162770	OCIAML3	viability	CAGCGACACTCACCCTCCGGCGG	PLK1	ENSG00000166851	-5.237863830098888	[24]	[1]	-9	hSpCas9	negative selection	12414783
23680930	23680953	16	+	28162770	OCIAML3	viability	AACCAAAGTCGAATATGACGGGG	PLK1	ENSG00000166851	-3.2460843369038566	[43]	[13]	-9	hSpCas9	negative selection	12414784
23683863	23683886	16	+	28162770	OCIAML3	viability	GCCCCAGCACATCAACCCCGTGG	PLK1	ENSG00000166851	-3.3251908818963636	[82]	[24]	-9	hSpCas9	negative selection	12414785
23683929	23683952	16	-	28162770	OCIAML3	viability	GCAGCTCGTTAATGGTTGGGCGG	PLK1	ENSG00000166851	-0.48865464017793453	[98]	[212]	-4	hSpCas9	negative selection	12414786