Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:10769
• Symbol:PLK2
• Description:polo like kinase 2

DataSource: http://genomecrispr.dkfz.de/#!/results/PLK2

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
58455738	58455761	5	-	26472758	Jiyoye	viability	GGGAAGTGTTGCAGACACAGTGG	PLK2	ENSG00000145632	-0.36885977733892494	[261]	[152]	-3	hSpCas9	negative selection	122440
58455702	58455725	5	-	26472758	Jiyoye	viability	GGGATGTCTGGAAAACATGCCGG	PLK2	ENSG00000145632	0.9597164045346522	[14]	[21]	6	hSpCas9	negative selection	122441
58459858	58459881	5	-	26472758	Jiyoye	viability	GAGCGGACTCGAAGAAGAAGCGG	PLK2	ENSG00000145632	1.510268874469977	[53]	[115]	8	hSpCas9	negative selection	122442
58459783	58459806	5	+	26472758	Jiyoye	viability	ATGGTGGTGAGGGGCCGCCGGGG	PLK2	ENSG00000145632	0.548037917345723	[116]	[128]	4	hSpCas9	negative selection	122443
58458132	58458155	5	-	26472758	Jiyoye	viability	GAAGCCATGGAACTAAAAGTTGG	PLK2	ENSG00000145632	1.263811206334696	[110]	[200]	7	hSpCas9	negative selection	122444
58455576	58455599	5	+	26472758	Jiyoye	viability	TGAAAAGGACACCGACGGTGTGG	PLK2	ENSG00000145632	0.06613846367080634	[227]	[179]	0	hSpCas9	negative selection	122445
58459893	58459916	5	-	26472758	Jiyoye	viability	CAAAATGTGCGAGCAGGCGCTGG	PLK2	ENSG00000145632	0.358265781024927	[59]	[57]	2	hSpCas9	negative selection	122446
58459875	58459898	5	-	26472758	Jiyoye	viability	GCTGGGCAAGGGTTGCGGAGCGG	PLK2	ENSG00000145632	-0.6923602920450409	[104]	[48]	-5	hSpCas9	negative selection	122447
58459824	58459847	5	+	26472758	Jiyoye	viability	GAGGTGGCTGCGATTCCTCGGGG	PLK2	ENSG00000145632	0.18786235310139748	[77]	[66]	1	hSpCas9	negative selection	122448
58459711	58459734	5	+	26472758	Jiyoye	viability	GCAGTAGCGCTTCCCAGTCGTGG	PLK2	ENSG00000145632	0.1414418260711242	[106]	[88]	1	hSpCas9	negative selection	122449
58455738	58455761	5	-	26472758	KBM7	viability	GGGAAGTGTTGCAGACACAGTGG	PLK2	ENSG00000145632	0.8948998147353812	[547,363]	[299,474]	8	hSpCas9	negative selection	313558
58455702	58455725	5	-	26472758	KBM7	viability	GGGATGTCTGGAAAACATGCCGG	PLK2	ENSG00000145632	0.3093353024775334	[199,116]	[121,61]	3	hSpCas9	negative selection	313559
58459858	58459881	5	-	26472758	KBM7	viability	GAGCGGACTCGAAGAAGAAGCGG	PLK2	ENSG00000145632	-0.2062383397102917	[682,478]	[248,219]	-2	hSpCas9	negative selection	313560
58459783	58459806	5	+	26472758	KBM7	viability	ATGGTGGTGAGGGGCCGCCGGGG	PLK2	ENSG00000145632	1.005483566149501	[297,223]	[328,167]	9	hSpCas9	negative selection	313561
58458132	58458155	5	-	26472758	KBM7	viability	GAAGCCATGGAACTAAAAGTTGG	PLK2	ENSG00000145632	-0.5748607256265986	[848,568]	[269,175]	-5	hSpCas9	negative selection	313562
58455576	58455599	5	+	26472758	KBM7	viability	TGAAAAGGACACCGACGGTGTGG	PLK2	ENSG00000145632	0.5810856918017231	[534,347]	[317,293]	6	hSpCas9	negative selection	313563
58459893	58459916	5	-	26472758	KBM7	viability	CAAAATGTGCGAGCAGGCGCTGG	PLK2	ENSG00000145632	-0.45457145532966226	[264,188]	[115,41]	-4	hSpCas9	negative selection	313564
58459875	58459898	5	-	26472758	KBM7	viability	GCTGGGCAAGGGTTGCGGAGCGG	PLK2	ENSG00000145632	0.7739639274323629	[425,310]	[330,258]	8	hSpCas9	negative selection	313565
58459824	58459847	5	+	26472758	KBM7	viability	GAGGTGGCTGCGATTCCTCGGGG	PLK2	ENSG00000145632	1.2120169240472995	[426,388]	[416,468]	9	hSpCas9	negative selection	313566
58459711	58459734	5	+	26472758	KBM7	viability	GCAGTAGCGCTTCCCAGTCGTGG	PLK2	ENSG00000145632	0.14529339966107607	[395,330]	[136,233]	1	hSpCas9	negative selection	313567
58455738	58455761	5	-	26472758	Raji	viability	GGGAAGTGTTGCAGACACAGTGG	PLK2	ENSG00000145632	0.7758693916570389	[150]	[59]	7	hSpCas9	negative selection	504676
58455702	58455725	5	-	26472758	Raji	viability	GGGATGTCTGGAAAACATGCCGG	PLK2	ENSG00000145632	-1.312155356140185	[106]	[9]	-7	hSpCas9	negative selection	504677
58459858	58459881	5	-	26472758	Raji	viability	GAGCGGACTCGAAGAAGAAGCGG	PLK2	ENSG00000145632	0.13725406495573741	[238]	[60]	1	hSpCas9	negative selection	504678
58459783	58459806	5	+	26472758	Raji	viability	ATGGTGGTGAGGGGCCGCCGGGG	PLK2	ENSG00000145632	1.0222161521109223	[156]	[73]	8	hSpCas9	negative selection	504679
58458132	58458155	5	-	26472758	Raji	viability	GAAGCCATGGAACTAAAAGTTGG	PLK2	ENSG00000145632	0.16804631728022357	[325]	[84]	1	hSpCas9	negative selection	504680
58455576	58455599	5	+	26472758	Raji	viability	TGAAAAGGACACCGACGGTGTGG	PLK2	ENSG00000145632	0.2888304067111314	[193]	[54]	2	hSpCas9	negative selection	504681
58459893	58459916	5	-	26472758	Raji	viability	CAAAATGTGCGAGCAGGCGCTGG	PLK2	ENSG00000145632	0.6729807112278245	[99]	[36]	6	hSpCas9	negative selection	504682
58459875	58459898	5	-	26472758	Raji	viability	GCTGGGCAAGGGTTGCGGAGCGG	PLK2	ENSG00000145632	-0.29471490819774604	[110]	[20]	-2	hSpCas9	negative selection	504683
58459824	58459847	5	+	26472758	Raji	viability	GAGGTGGCTGCGATTCCTCGGGG	PLK2	ENSG00000145632	0.4713468500581741	[114]	[36]	4	hSpCas9	negative selection	504684
58459711	58459734	5	+	26472758	Raji	viability	GCAGTAGCGCTTCCCAGTCGTGG	PLK2	ENSG00000145632	-0.5146682840827768	[196]	[31]	-4	hSpCas9	negative selection	504685
58455738	58455761	5	-	26472758	K562	viability	GGGAAGTGTTGCAGACACAGTGG	PLK2	ENSG00000145632	0.6649438525837215	[327]	[438]	5	hSpCas9	negative selection	695794
58455702	58455725	5	-	26472758	K562	viability	GGGATGTCTGGAAAACATGCCGG	PLK2	ENSG00000145632	1.2727077720978706	[100]	[205]	9	hSpCas9	negative selection	695795
58459858	58459881	5	-	26472758	K562	viability	GAGCGGACTCGAAGAAGAAGCGG	PLK2	ENSG00000145632	0.12748476792494368	[577]	[532]	0	hSpCas9	negative selection	695796
58459783	58459806	5	+	26472758	K562	viability	ATGGTGGTGAGGGGCCGCCGGGG	PLK2	ENSG00000145632	0.7683197026513243	[184]	[265]	6	hSpCas9	negative selection	695797
58458132	58458155	5	-	26472758	K562	viability	GAAGCCATGGAACTAAAAGTTGG	PLK2	ENSG00000145632	-0.4346519279470611	[577]	[360]	-3	hSpCas9	negative selection	695798
58455576	58455599	5	+	26472758	K562	viability	TGAAAAGGACACCGACGGTGTGG	PLK2	ENSG00000145632	0.17562795400052605	[450]	[429]	1	hSpCas9	negative selection	695799
58459893	58459916	5	-	26472758	K562	viability	CAAAATGTGCGAGCAGGCGCTGG	PLK2	ENSG00000145632	0.8327402404775176	[142]	[214]	7	hSpCas9	negative selection	695800
58459875	58459898	5	-	26472758	K562	viability	GCTGGGCAAGGGTTGCGGAGCGG	PLK2	ENSG00000145632	-0.07667277975711992	[430]	[344]	0	hSpCas9	negative selection	695801
58459824	58459847	5	+	26472758	K562	viability	GAGGTGGCTGCGATTCCTCGGGG	PLK2	ENSG00000145632	-0.01581704481467361	[308]	[257]	0	hSpCas9	negative selection	695802
58459711	58459734	5	+	26472758	K562	viability	GCAGTAGCGCTTCCCAGTCGTGG	PLK2	ENSG00000145632	-0.42363938881817154	[401]	[252]	-3	hSpCas9	negative selection	695803
58454963	58454986	5	+	26627737	DLD1	viability	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	0.22786087954749656	[1073]	[446,429,315]	2	hSpCas9	negative selection	829111
58455643	58455666	5	-	26627737	DLD1	viability	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	0.5864955748432347	[306]	[91,205,137]	6	hSpCas9	negative selection	829112
58456105	58456128	5	+	26627737	DLD1	viability	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	0.5005560131983465	[683]	[269,353,287]	5	hSpCas9	negative selection	829113
58457530	58457553	5	-	26627737	DLD1	viability	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	0.5343593625120786	[1145]	[520,653,404]	5	hSpCas9	negative selection	829114
58458081	58458104	5	+	26627737	DLD1	viability	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	0.2796192917486111	[220]	[62,55,124]	3	hSpCas9	negative selection	829115
58459826	58459849	5	+	26627737	DLD1	viability	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	0.12765579005962824	[95]	[17,47,32]	1	hSpCas9	negative selection	829116
58454963	58454986	5	+	26627737	GBM cells	viability after 5 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	0.3109859156879683	[486]	[295,351]	5	hSpCas9	negative selection	911426
58455643	58455666	5	-	26627737	GBM cells	viability after 5 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	0.14438990933517493	[247]	[134,158]	2	hSpCas9	negative selection	911427
58456105	58456128	5	+	26627737	GBM cells	viability after 5 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	-0.10910111817843399	[360]	[177,180]	-2	hSpCas9	negative selection	911428
58457530	58457553	5	-	26627737	GBM cells	viability after 5 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	0.048139883660161864	[779]	[397,466]	0	hSpCas9	negative selection	911429
58458081	58458104	5	+	26627737	GBM cells	viability after 5 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	-0.3113038325046602	[117]	[60,40]	-5	hSpCas9	negative selection	911430
58459826	58459849	5	+	26627737	GBM cells	viability after 5 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	-1.0750909165813702	[54]	[9,17]	-9	hSpCas9	negative selection	911431
58454963	58454986	5	+	26627737	GBM cells	viability after 13 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	0.4771374408886405	[486]	[326,400]	6	hSpCas9	negative selection	993741
58455643	58455666	5	-	26627737	GBM cells	viability after 13 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	0.23316387625165616	[247]	[209,115]	3	hSpCas9	negative selection	993742
58456105	58456128	5	+	26627737	GBM cells	viability after 13 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	-0.19521716046050558	[360]	[196,149]	-2	hSpCas9	negative selection	993743
58457530	58457553	5	-	26627737	GBM cells	viability after 13 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	0.17290734519953577	[779]	[609,368]	2	hSpCas9	negative selection	993744
58458081	58458104	5	+	26627737	GBM cells	viability after 13 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	0.08551822499323258	[117]	[73,62]	1	hSpCas9	negative selection	993745
58459826	58459849	5	+	26627737	GBM cells	viability after 13 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	-0.410707556989772	[54]	[22,21]	-5	hSpCas9	negative selection	993746
58454963	58454986	5	+	26627737	GBM cells	viability after 21 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	0.7693678728071666	[486]	[474,428]	7	hSpCas9	negative selection	1076056
58455643	58455666	5	-	26627737	GBM cells	viability after 21 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	0.4361198060227497	[247]	[198,166]	4	hSpCas9	negative selection	1076057
58456105	58456128	5	+	26627737	GBM cells	viability after 21 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	-0.21597589092843872	[360]	[183,154]	-2	hSpCas9	negative selection	1076058
58457530	58457553	5	-	26627737	GBM cells	viability after 21 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	0.06178441787733879	[779]	[446,437]	0	hSpCas9	negative selection	1076059
58458081	58458104	5	+	26627737	GBM cells	viability after 21 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	0.6649778043358148	[117]	[109,93]	6	hSpCas9	negative selection	1076060
58459826	58459849	5	+	26627737	GBM cells	viability after 21 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	0.05513679517078707	[54]	[29,31]	0	hSpCas9	negative selection	1076061
58454963	58454986	5	+	26627737	RPE1	viability after 9 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	-1.0225716977003692	[3533]	[565,516]	-6	hSpCas9	negative selection	1158371
58455643	58455666	5	-	26627737	RPE1	viability after 9 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	-0.8820589002026398	[971]	[127,212]	-6	hSpCas9	negative selection	1158372
58456105	58456128	5	+	26627737	RPE1	viability after 9 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	-0.48910433938452	[1652]	[345,397]	-3	hSpCas9	negative selection	1158373
58457530	58457553	5	-	26627737	RPE1	viability after 9 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	-1.388157046141096	[3989]	[409,563]	-7	hSpCas9	negative selection	1158374
58458081	58458104	5	+	26627737	RPE1	viability after 9 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	0.5302402268667175	[227]	[51,168]	3	hSpCas9	negative selection	1158375
58459826	58459849	5	+	26627737	RPE1	viability after 9 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	1.0319078001168824	[19]	[7,18]	6	hSpCas9	negative selection	1158376
58454963	58454986	5	+	26627737	RPE1	viability after 12 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	-0.9256028856962337	[3533]	[392,612]	-6	hSpCas9	negative selection	1240686
58455643	58455666	5	-	26627737	RPE1	viability after 12 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	-0.8947149085049481	[971]	[104,177]	-6	hSpCas9	negative selection	1240687
58456105	58456128	5	+	26627737	RPE1	viability after 12 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	-0.6358974914107219	[1652]	[312,256]	-4	hSpCas9	negative selection	1240688
58457530	58457553	5	-	26627737	RPE1	viability after 12 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	-1.2885479692890112	[3989]	[449,426]	-7	hSpCas9	negative selection	1240689
58458081	58458104	5	+	26627737	RPE1	viability after 12 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	-0.4141130087131242	[227]	[10,82]	-3	hSpCas9	negative selection	1240690
58459826	58459849	5	+	26627737	RPE1	viability after 12 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	2.313722854615808	[19]	[50,0]	9	hSpCas9	negative selection	1240691
58454963	58454986	5	+	26627737	RPE1	viability after 15 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	-0.2691212369607887	[3533]	[881,778]	-2	hSpCas9	negative selection	1323001
58455643	58455666	5	-	26627737	RPE1	viability after 15 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	-0.8753551317059411	[971]	[71,224]	-5	hSpCas9	negative selection	1323002
58456105	58456128	5	+	26627737	RPE1	viability after 15 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	-0.7010116167237521	[1652]	[307,267]	-4	hSpCas9	negative selection	1323003
58457530	58457553	5	-	26627737	RPE1	viability after 15 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	-1.2326838077845104	[3989]	[604,359]	-6	hSpCas9	negative selection	1323004
58458081	58458104	5	+	26627737	RPE1	viability after 15 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	0.47278404117825024	[227]	[60,116]	3	hSpCas9	negative selection	1323005
58459826	58459849	5	+	26627737	RPE1	viability after 15 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	0.7241935644492203	[19]	[17,0]	4	hSpCas9	negative selection	1323006
58454963	58454986	5	+	26627737	RPE1	viability after 18 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	0.12086123370395807	[3533]	[994,1081]	0	hSpCas9	negative selection	1405316
58455643	58455666	5	-	26627737	RPE1	viability after 18 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	-0.9996349901440154	[971]	[92,171]	-6	hSpCas9	negative selection	1405317
58456105	58456128	5	+	26627737	RPE1	viability after 18 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	-0.15468242804140564	[1652]	[363,439]	-1	hSpCas9	negative selection	1405318
58457530	58457553	5	-	26627737	RPE1	viability after 18 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	-1.374499648620793	[3989]	[423,405]	-7	hSpCas9	negative selection	1405319
58458081	58458104	5	+	26627737	RPE1	viability after 18 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	0.3233871804456614	[227]	[32,123]	2	hSpCas9	negative selection	1405320
58459826	58459849	5	+	26627737	RPE1	viability after 18 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	1.4696079212967055	[19]	[27,0]	7	hSpCas9	negative selection	1405321
58454963	58454986	5	+	26627737	HeLa	viability after 8 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	-0.3671739975073618	[1222]	[606,148,516]	-4	hSpCas9	negative selection	1487631
58455643	58455666	5	-	26627737	HeLa	viability after 8 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	0.4751363769588992	[164]	[106,123,71]	4	hSpCas9	negative selection	1487632
58456105	58456128	5	+	26627737	HeLa	viability after 8 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	-0.8556246047823741	[996]	[197,241,267]	-7	hSpCas9	negative selection	1487633
58457530	58457553	5	-	26627737	HeLa	viability after 8 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	0.12141272062010877	[1167]	[569,400,681]	1	hSpCas9	negative selection	1487634
58458081	58458104	5	+	26627737	HeLa	viability after 8 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	-2.0476892645867992	[256]	[13,47,16]	-9	hSpCas9	negative selection	1487635
58459826	58459849	5	+	26627737	HeLa	viability after 8 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	-0.3696056880375618	[98]	[40,1,56]	-4	hSpCas9	negative selection	1487636
58454963	58454986	5	+	26627737	HeLa	viability after 12 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	-0.5258917275138775	[1222]	[281,332,437]	-5	hSpCas9	negative selection	1569946
58455643	58455666	5	-	26627737	HeLa	viability after 12 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	0.8930170134601488	[164]	[138,128,111]	7	hSpCas9	negative selection	1569947
58456105	58456128	5	+	26627737	HeLa	viability after 12 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	-1.2203988455664074	[996]	[167,244,109]	-8	hSpCas9	negative selection	1569948
58457530	58457553	5	-	26627737	HeLa	viability after 12 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	0.3449651573833987	[1167]	[591,618,626]	3	hSpCas9	negative selection	1569949
58458081	58458104	5	+	26627737	HeLa	viability after 12 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	-1.79897379513621	[256]	[17,22,50]	-9	hSpCas9	negative selection	1569950
58459826	58459849	5	+	26627737	HeLa	viability after 12 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	0.8180779088715946	[98]	[103,27,89]	6	hSpCas9	negative selection	1569951
58454963	58454986	5	+	26627737	HeLa	viability after 15 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	-0.8656155467264437	[1222]	[159,172,505]	-6	hSpCas9	negative selection	1652261
58455643	58455666	5	-	26627737	HeLa	viability after 15 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	0.6307312915626226	[164]	[87,134,87]	5	hSpCas9	negative selection	1652262
58456105	58456128	5	+	26627737	HeLa	viability after 15 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	-1.1353473918645773	[996]	[112,223,220]	-7	hSpCas9	negative selection	1652263
58457530	58457553	5	-	26627737	HeLa	viability after 15 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	0.010835611324968575	[1167]	[502,441,492]	0	hSpCas9	negative selection	1652264
58458081	58458104	5	+	26627737	HeLa	viability after 15 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	-1.10944484615406	[256]	[58,53,30]	-7	hSpCas9	negative selection	1652265
58459826	58459849	5	+	26627737	HeLa	viability after 15 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	-1.5040593874914492	[98]	[0,0,42]	-8	hSpCas9	negative selection	1652266
58454963	58454986	5	+	26627737	HeLa	viability after 18 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	-0.8503699792925927	[1222]	[109,146,505]	-6	hSpCas9	negative selection	1734576
58455643	58455666	5	-	26627737	HeLa	viability after 18 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	0.6057574403124477	[164]	[52,114,87]	5	hSpCas9	negative selection	1734577
58456105	58456128	5	+	26627737	HeLa	viability after 18 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	-1.08176827354883	[996]	[80,195,220]	-7	hSpCas9	negative selection	1734578
58457530	58457553	5	-	26627737	HeLa	viability after 18 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	0.02640829132689393	[1167]	[345,367,492]	0	hSpCas9	negative selection	1734579
58458081	58458104	5	+	26627737	HeLa	viability after 18 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	-1.0489060969124866	[256]	[40,47,30]	-7	hSpCas9	negative selection	1734580
58459826	58459849	5	+	26627737	HeLa	viability after 18 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	-1.479906817166851	[98]	[0,0,42]	-8	hSpCas9	negative selection	1734581
58454963	58454986	5	+	26627737	HCT116	viability after 6 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	1.6359468883492314	[1829]	[469,1127]	8	hSpCas9	negative selection	1816891
58455643	58455666	5	-	26627737	HCT116	viability after 6 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	-1.8910343084060017	[334]	[19,10]	-8	hSpCas9	negative selection	1816892
58456105	58456128	5	+	26627737	HCT116	viability after 6 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	-1.6493904955820933	[1837]	[104,84]	-7	hSpCas9	negative selection	1816893
58457530	58457553	5	-	26627737	HCT116	viability after 6 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	-0.773566773482104	[2017]	[318,111]	-4	hSpCas9	negative selection	1816894
58458081	58458104	5	+	26627737	HCT116	viability after 6 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	-3.2025178440172857	[120]	[3,0]	-9	hSpCas9	negative selection	1816895
58459826	58459849	5	+	26627737	HCT116	viability after 6 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	6.750677433601604	[0]	[43,1]	9	hSpCas9	negative selection	1816896
58454963	58454986	5	+	26627737	HCT116	viability after 8 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	-0.40157363846326855	[716]	[278,242,373]	-5	hSpCas9	negative selection	1899206
58455643	58455666	5	-	26627737	HCT116	viability after 8 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	0.7363371994633656	[130]	[113,154,91]	7	hSpCas9	negative selection	1899207
58456105	58456128	5	+	26627737	HCT116	viability after 8 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	-0.3672221224736597	[598]	[295,266,205]	-4	hSpCas9	negative selection	1899208
58457530	58457553	5	-	26627737	HCT116	viability after 8 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	-0.2200464703219982	[1038]	[458,440,572]	-3	hSpCas9	negative selection	1899209
58458081	58458104	5	+	26627737	HCT116	viability after 8 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	0.9271940306059174	[67]	[90,42,79]	8	hSpCas9	negative selection	1899210
58459826	58459849	5	+	26627737	HCT116	viability after 8 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	-1.8677602896803673	[172]	[18,13,44]	-9	hSpCas9	negative selection	1899211
58454963	58454986	5	+	26627737	HCT116	viability after 9 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	0.28642135716935435	[1829]	[810,425]	2	hSpCas9	negative selection	1981521
58455643	58455666	5	-	26627737	HCT116	viability after 9 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	0.2352971224617263	[334]	[111,99]	1	hSpCas9	negative selection	1981522
58456105	58456128	5	+	26627737	HCT116	viability after 9 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	-1.6832433857043763	[1837]	[144,158]	-8	hSpCas9	negative selection	1981523
58457530	58457553	5	-	26627737	HCT116	viability after 9 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	-0.1091326061407707	[2017]	[307,650]	0	hSpCas9	negative selection	1981524
58458081	58458104	5	+	26627737	HCT116	viability after 9 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	-0.712892269478675	[120]	[31,9]	-5	hSpCas9	negative selection	1981525
58459826	58459849	5	+	26627737	HCT116	viability after 9 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	2.545202172640087	[0]	[0,1]	9	hSpCas9	negative selection	1981526
58454963	58454986	5	+	26627737	HCT116	viability after 12 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	0.09445072897559315	[716]	[354,317,535]	1	hSpCas9	negative selection	2063836
58455643	58455666	5	-	26627737	HCT116	viability after 12 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	0.8925246874682089	[130]	[108,83,190]	7	hSpCas9	negative selection	2063837
58456105	58456128	5	+	26627737	HCT116	viability after 12 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	0.27729980745972727	[598]	[414,316,407]	3	hSpCas9	negative selection	2063838
58457530	58457553	5	-	26627737	HCT116	viability after 12 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	0.05745240931361417	[1038]	[562,523,616]	0	hSpCas9	negative selection	2063839
58458081	58458104	5	+	26627737	HCT116	viability after 12 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	0.6112678692286253	[67]	[15,47,102]	6	hSpCas9	negative selection	2063840
58459826	58459849	5	+	26627737	HCT116	viability after 12 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	-1.2409551621928734	[172]	[36,57,20]	-8	hSpCas9	negative selection	2063841
58454963	58454986	5	+	26627737	HCT116	viability after 15 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	-0.11326148635376021	[716]	[470,381,300]	-1	hSpCas9	negative selection	2146151
58455643	58455666	5	-	26627737	HCT116	viability after 15 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	0.4785594452701645	[130]	[134,65,116]	4	hSpCas9	negative selection	2146152
58456105	58456128	5	+	26627737	HCT116	viability after 15 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	-0.04994112841198628	[598]	[362,335,301]	0	hSpCas9	negative selection	2146153
58457530	58457553	5	-	26627737	HCT116	viability after 15 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	0.1737531368132148	[1038]	[850,529,659]	1	hSpCas9	negative selection	2146154
58458081	58458104	5	+	26627737	HCT116	viability after 15 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	-0.028067063076934406	[67]	[38,38,36]	0	hSpCas9	negative selection	2146155
58459826	58459849	5	+	26627737	HCT116	viability after 15 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	-1.1817652310754894	[172]	[26,29,71]	-8	hSpCas9	negative selection	2146156
58454963	58454986	5	+	26627737	HCT116	viability after 18 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	0.1959302567741803	[716]	[393,356,444]	1	hSpCas9	negative selection	2228466
58455643	58455666	5	-	26627737	HCT116	viability after 18 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	1.1505977845013735	[130]	[158,79,188]	8	hSpCas9	negative selection	2228467
58456105	58456128	5	+	26627737	HCT116	viability after 18 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	0.3724976449174011	[598]	[427,281,422]	3	hSpCas9	negative selection	2228468
58457530	58457553	5	-	26627737	HCT116	viability after 18 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	0.06928992705812798	[1038]	[493,523,564]	0	hSpCas9	negative selection	2228469
58458081	58458104	5	+	26627737	HCT116	viability after 18 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	-0.8055089480524198	[67]	[3,19,32]	-6	hSpCas9	negative selection	2228470
58459826	58459849	5	+	26627737	HCT116	viability after 18 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	-3.9427601506468206	[172]	[1,0,13]	-9	hSpCas9	negative selection	2228471
58459707	58459730	5	-	24336569	HL60	viability	GACTGGGAAGCGCTACTGCCGGG	PLK2	ENSG00000145632	1.0672933333124994	[533]	[2367]	7	hSpCas9	negative selection	2284614
58459712	58459735	5	+	24336569	HL60	viability	CAGTAGCGCTTCCCAGTCGTGGG	PLK2	ENSG00000145632	-0.26594785804111143	[553]	[974]	-2	hSpCas9	negative selection	2284615
58459805	58459828	5	+	24336569	HL60	viability	GGCACTTGCGCCTGGGACTGAGG	PLK2	ENSG00000145632	0.7574149097622369	[484]	[1734]	6	hSpCas9	negative selection	2284616
58459815	58459838	5	-	24336569	HL60	viability	ATCGCAGCCACCTCAGTCCCAGG	PLK2	ENSG00000145632	0.6113831571641398	[424]	[1373]	5	hSpCas9	negative selection	2284617
58459822	58459845	5	+	24336569	HL60	viability	CTGAGGTGGCTGCGATTCCTCGG	PLK2	ENSG00000145632	-0.7565947304294114	[391]	[490]	-6	hSpCas9	negative selection	2284618
58459858	58459881	5	-	24336569	HL60	viability	GAGCGGACTCGAAGAAGAAGCGG	PLK2	ENSG00000145632	1.7393866639129307	[227]	[1610]	9	hSpCas9	negative selection	2284619
58459875	58459898	5	-	24336569	HL60	viability	GCTGGGCAAGGGTTGCGGAGCGG	PLK2	ENSG00000145632	1.6634658172570114	[279]	[1876]	9	hSpCas9	negative selection	2284620
58459880	58459903	5	-	24336569	HL60	viability	CAGGCGCTGGGCAAGGGTTGCGG	PLK2	ENSG00000145632	1.1515952457594074	[384]	[1809]	8	hSpCas9	negative selection	2284621
58459886	58459909	5	-	24336569	HL60	viability	TGCGAGCAGGCGCTGGGCAAGGG	PLK2	ENSG00000145632	-0.1462861016851389	[1137]	[2175]	-1	hSpCas9	negative selection	2284622
58459915	58459938	5	+	24336569	HL60	viability	GGTGCTGGCGGCTGGCTGGTAGG	PLK2	ENSG00000145632	7.971103950175257	[0]	[530]	9	hSpCas9	negative selection	2284623
58459707	58459730	5	-	24336569	KBM7	viability	GACTGGGAAGCGCTACTGCCGGG	PLK2	ENSG00000145632	-0.24567615074539045	[465]	[1071]	-2	hSpCas9	negative selection	2351791
58459712	58459735	5	+	24336569	KBM7	viability	CAGTAGCGCTTCCCAGTCGTGGG	PLK2	ENSG00000145632	-0.6850339764655653	[681]	[1156]	-5	hSpCas9	negative selection	2351792
58459805	58459828	5	+	24336569	KBM7	viability	GGCACTTGCGCCTGGGACTGAGG	PLK2	ENSG00000145632	0.5711053667160442	[536]	[2175]	5	hSpCas9	negative selection	2351793
58459815	58459838	5	-	24336569	KBM7	viability	ATCGCAGCCACCTCAGTCCCAGG	PLK2	ENSG00000145632	0.12404866567066303	[470]	[1399]	1	hSpCas9	negative selection	2351794
58459822	58459845	5	+	24336569	KBM7	viability	CTGAGGTGGCTGCGATTCCTCGG	PLK2	ENSG00000145632	0.6532512449066519	[296]	[1273]	6	hSpCas9	negative selection	2351795
58459858	58459881	5	-	24336569	KBM7	viability	GAGCGGACTCGAAGAAGAAGCGG	PLK2	ENSG00000145632	-0.15394014609294385	[411]	[1009]	-1	hSpCas9	negative selection	2351796
58459875	58459898	5	-	24336569	KBM7	viability	GCTGGGCAAGGGTTGCGGAGCGG	PLK2	ENSG00000145632	0.26946282707962754	[750]	[2468]	2	hSpCas9	negative selection	2351797
58459880	58459903	5	-	24336569	KBM7	viability	CAGGCGCTGGGCAAGGGTTGCGG	PLK2	ENSG00000145632	0.01969402765822567	[416]	[1152]	0	hSpCas9	negative selection	2351798
58459886	58459909	5	-	24336569	KBM7	viability	TGCGAGCAGGCGCTGGGCAAGGG	PLK2	ENSG00000145632	0.7551844180386329	[665]	[3065]	6	hSpCas9	negative selection	2351799
58459915	58459938	5	+	24336569	KBM7	viability	GGTGCTGGCGGCTGGCTGGTAGG	PLK2	ENSG00000145632	-0.8881517879348639	[170]	[251]	-6	hSpCas9	negative selection	2351800
58460229	58460252	5	-	25494202	A375	resistance to PLX-4720 (puromycin)	TCCGCTGGGAAGCGAGACCCGGG	PLK2	ENSG00000145632	-1.5424605063342114	[589,386]	[49,20]	-8	dCas9-VP64	positive selection	2415545
58460229	58460252	5	-	25494202	A375	resistance to PLX-4720 (zeocin)	TCCGCTGGGAAGCGAGACCCGGG	PLK2	ENSG00000145632	1.4595058512299186	[170,225]	[37,308]	7	dCas9-VP64	positive selection	2510800
58458724	58458747	5	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CTTGGAATACTGCAGTAGAAGGG	PLK2	ENSG00000145632	0.15716212680840125	[4,5]	[3,5]	3	hSpCas9	positive selection	3012013
58459940	58459963	5	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GATAGTCCGCAAAAGCTCCATGG	PLK2	ENSG00000145632	-0.1994979915884048	[2,2]	[3,0]	-3	hSpCas9	positive selection	3012014
58457270	58457293	5	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCAGGAGCCAGCAATGAGGACGG	PLK2	ENSG00000145632	0.39388067721906517	[3,3]	[3,4]	7	hSpCas9	positive selection	3012015
58457228	58457251	5	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TATGTTGTCCAAAAACCCAGAGG	PLK2	ENSG00000145632	-0.00635399132381257	[3,3]	[3,2]	0	hSpCas9	positive selection	3012016
58458724	58458747	5	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CTTGGAATACTGCAGTAGAAGGG	PLK2	ENSG00000145632	0.10277879720613575	[4,4]	[3,2]	1	hSpCas9	positive selection	3079871
58459940	58459963	5	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GATAGTCCGCAAAAGCTCCATGG	PLK2	ENSG00000145632	-0.07381164659728937	[2,2]	[2,0]	-1	hSpCas9	positive selection	3079872
58457270	58457293	5	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCAGGAGCCAGCAATGAGGACGG	PLK2	ENSG00000145632	-0.09352816720019394	[3,3]	[2,1]	-1	hSpCas9	positive selection	3079873
58457228	58457251	5	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TATGTTGTCCAAAAACCCAGAGG	PLK2	ENSG00000145632	-0.5529709342935825	[3,3]	[2,0]	-7	hSpCas9	positive selection	3079874
58458118	58458141		-	24336571	A375	resistance to PLX after 7 days	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	0.21638667240056741	[3,4]	[5,4]	6	hSpCas9	positive selection	3136279
58458769	58458792		-	24336571	A375	resistance to PLX after 7 days	GCAGTTTTACCACTACTTCGAGG	PLK2	ENSG00000145632	-0.09047784750473525	[8,8]	[8,7]	-3	hSpCas9	positive selection	3136280
58458128	58458151		+	24336571	A375	resistance to PLX after 7 days	GTCCCCAACTTTTAGTTCCATGG	PLK2	ENSG00000145632	0.06045080724417484	[9,9]	[10,9]	2	hSpCas9	positive selection	3136281
58458760	58458783		+	24336571	A375	resistance to PLX after 7 days	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	-0.3450602614120148	[11,9]	[9,6]	-8	hSpCas9	positive selection	3136282
58458118	58458141		-	24336571	A375	resistance to PLX after 14 days	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	0.3760366730949416	[4,2]	[2,1]	3	hSpCas9	positive selection	3194072
58458769	58458792		-	24336571	A375	resistance to PLX after 14 days	GCAGTTTTACCACTACTTCGAGG	PLK2	ENSG00000145632	-0.8382302486018617	[8,10]	[1,2]	-8	hSpCas9	positive selection	3194073
58458128	58458151		+	24336571	A375	resistance to PLX after 14 days	GTCCCCAACTTTTAGTTCCATGG	PLK2	ENSG00000145632	-0.42777315740369165	[8,10]	[2,3]	-5	hSpCas9	positive selection	3194074
58458760	58458783		+	24336571	A375	resistance to PLX after 14 days	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	-0.3088045861522797	[7,6]	[2,1]	-4	hSpCas9	positive selection	3194075
58458118	58458141		-	24336571	A375	viability after 7 days	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	-0.7817037711930872	[8]	[3,4]	-8	hSpCas9	negative selection	3251865
58458769	58458792		-	24336571	A375	viability after 7 days	GCAGTTTTACCACTACTTCGAGG	PLK2	ENSG00000145632	-0.5714536510916073	[14]	[8,8]	-7	hSpCas9	negative selection	3251866
58458128	58458151		+	24336571	A375	viability after 7 days	GTCCCCAACTTTTAGTTCCATGG	PLK2	ENSG00000145632	-0.05585864003405888	[10]	[9,9]	-1	hSpCas9	negative selection	3251867
58458760	58458783		+	24336571	A375	viability after 7 days	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.33060821219447983	[8]	[11,9]	5	hSpCas9	negative selection	3251868
58458118	58458141		-	24336571	A375	viability after 14 days	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	-0.99343775783723	[8]	[4,2]	-8	hSpCas9	negative selection	3309658
58458769	58458792		-	24336571	A375	viability after 14 days	GCAGTTTTACCACTACTTCGAGG	PLK2	ENSG00000145632	-0.38765796707827227	[14]	[8,10]	-4	hSpCas9	negative selection	3309659
58458128	58458151		+	24336571	A375	viability after 14 days	GTCCCCAACTTTTAGTTCCATGG	PLK2	ENSG00000145632	-0.05677722207803981	[10]	[8,10]	0	hSpCas9	negative selection	3309660
58458760	58458783		+	24336571	A375	viability after 14 days	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	-0.17765636656057904	[8]	[7,6]	-2	hSpCas9	negative selection	3309661
58458463	58458486	5	-	27383988	293T	resistance to West Nile virus (flavivirus)	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.6555631247841265	[240,240]	[0,0]	-4	hSpCas9	positive selection	3386369
58458417	58458440	5	+	27383988	293T	resistance to West Nile virus (flavivirus)	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	0.5158592250446882	[106,106]	[0,0]	2	hSpCas9	positive selection	3386370
58458086	58458109	5	-	27383988	293T	resistance to West Nile virus (flavivirus)	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	1.0093986980022496	[75,75]	[0,0]	4	hSpCas9	positive selection	3386371
58458724	58458747	5	-	26780180	HT29	viability (Avana library 4 designs)	CTTGGAATACTGCAGTAGAAGGG	PLK2	ENSG00000145632	0.244776946728944	[]	[]	0	hSpCas9	negative selection	3450112
58459939	58459962	5	+	26780180	HT29	viability (Avana library 4 designs)	GATAGTCCGCAAAAGCTCCATGG	PLK2	ENSG00000145632	0.764647540605182	[]	[]	3	hSpCas9	negative selection	3450113
58457269	58457292	5	+	26780180	HT29	viability (Avana library 4 designs)	GCAGGAGCCAGCAATGAGGACGG	PLK2	ENSG00000145632	0.987617473482226	[]	[]	4	hSpCas9	negative selection	3450114
58457228	58457251	5	-	26780180	HT29	viability (Avana library 4 designs)	TATGTTGTCCAAAAACCCAGAGG	PLK2	ENSG00000145632	1.1590653604289	[]	[]	4	hSpCas9	negative selection	3450115
58458724	58458747	5	-	26780180	A375	viability (Avana lentiCRISPRv2)	CTTGGAATACTGCAGTAGAAGGG	PLK2	ENSG00000145632	1.52235826843	[]	[]	2	hSpCas9	negative selection	3545198
58457228	58457251	5	-	26780180	A375	viability (Avana lentiCRISPRv2)	TATGTTGTCCAAAAACCCAGAGG	PLK2	ENSG00000145632	-5.47936810999079	[]	[]	-5	hSpCas9	negative selection	3545199
58459939	58459962	5	+	26780180	A375	viability (Avana lentiCRISPRv2)	GATAGTCCGCAAAAGCTCCATGG	PLK2	ENSG00000145632	-2.48174253720368	[]	[]	-3	hSpCas9	negative selection	3545200
58457269	58457292	5	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCAGGAGCCAGCAATGAGGACGG	PLK2	ENSG00000145632	3.2565523463687	[]	[]	5	hSpCas9	negative selection	3545201
58459826	58459849	5	+	26780180	A375	viability (Avana lentiCRISPRv2)	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	3.8321663012333	[]	[]	6	hSpCas9	negative selection	3545202
58457309	58457332	5	-	26780180	A375	viability (Avana lentiCRISPRv2)	AGAAACTTATAGGTGCATAAGGG	PLK2	ENSG00000145632	-10.2940246363422	[]	[]	-7	hSpCas9	negative selection	3545203
58458724	58458747	5	-	26780180	A375	viability (Avana lentiGuide)	CTTGGAATACTGCAGTAGAAGGG	PLK2	ENSG00000145632	-6.05115965041152	[]	[]	-8	hSpCas9	negative selection	3653857
58457228	58457251	5	-	26780180	A375	viability (Avana lentiGuide)	TATGTTGTCCAAAAACCCAGAGG	PLK2	ENSG00000145632	-2.73555757754543	[]	[]	-5	hSpCas9	negative selection	3653858
58459939	58459962	5	+	26780180	A375	viability (Avana lentiGuide)	GATAGTCCGCAAAAGCTCCATGG	PLK2	ENSG00000145632	2.70275943938929	[]	[]	3	hSpCas9	negative selection	3653859
58457269	58457292	5	+	26780180	A375	viability (Avana lentiGuide)	GCAGGAGCCAGCAATGAGGACGG	PLK2	ENSG00000145632	1.63559577943587	[]	[]	1	hSpCas9	negative selection	3653860
58459826	58459849	5	+	26780180	A375	viability (Avana lentiGuide)	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	-1.98145363362349	[]	[]	-3	hSpCas9	negative selection	3653861
58457309	58457332	5	-	26780180	A375	viability (Avana lentiGuide)	AGAAACTTATAGGTGCATAAGGG	PLK2	ENSG00000145632	-3.22441938124363	[]	[]	-5	hSpCas9	negative selection	3653862
58458724	58458747	5	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CTTGGAATACTGCAGTAGAAGGG	PLK2	ENSG00000145632	-0.07149244590220849	[6]	[6,5]	-1	hSpCas9	positive selection	3762516
58457228	58457251	5	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TATGTTGTCCAAAAACCCAGAGG	PLK2	ENSG00000145632	-0.7508582072127294	[5]	[1,3]	-8	hSpCas9	positive selection	3762517
58459939	58459962	5	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GATAGTCCGCAAAAGCTCCATGG	PLK2	ENSG00000145632	-0.4040103105071404	[4]	[3,2]	-5	hSpCas9	positive selection	3762518
58457269	58457292	5	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCAGGAGCCAGCAATGAGGACGG	PLK2	ENSG00000145632	0.298534635830586	[4]	[5,5]	8	hSpCas9	positive selection	3762519
58459826	58459849	5	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	0.23570153786638698	[5]	[6,5]	6	hSpCas9	positive selection	3762520
58457309	58457332	5	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AGAAACTTATAGGTGCATAAGGG	PLK2	ENSG00000145632	-0.5360387425694361	[8]	[5,5]	-6	hSpCas9	positive selection	3762521
58458724	58458747	5	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CTTGGAATACTGCAGTAGAAGGG	PLK2	ENSG00000145632	0.300153146195858	[6]	[6,5]	8	hSpCas9	positive selection	3871123
58457228	58457251	5	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TATGTTGTCCAAAAACCCAGAGG	PLK2	ENSG00000145632	-0.28175240727600953	[5]	[2,4]	-4	hSpCas9	positive selection	3871124
58459939	58459962	5	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GATAGTCCGCAAAAGCTCCATGG	PLK2	ENSG00000145632	-0.15302919463683845	[4]	[3,2]	-2	hSpCas9	positive selection	3871125
58457269	58457292	5	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCAGGAGCCAGCAATGAGGACGG	PLK2	ENSG00000145632	-0.4260854140253566	[4]	[1,3]	-5	hSpCas9	positive selection	3871126
58459826	58459849	5	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	0.16002019964977968	[6]	[5,6]	4	hSpCas9	positive selection	3871127
58457309	58457332	5	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AGAAACTTATAGGTGCATAAGGG	PLK2	ENSG00000145632	0.22112647140743572	[5]	[6,4]	5	hSpCas9	positive selection	3871128
58458118	58458141	5	-	26780180	A375	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	-0.0327979292708281	[]	[]	-1	hSpCas9	negative selection	3981953
58458463	58458486	5	-	26780180	A375	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	1.87947579458937	[]	[]	9	hSpCas9	negative selection	3981954
58458991	58459014	5	-	26780180	A375	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	1.39767129220527	[]	[]	7	hSpCas9	negative selection	3981955
58458417	58458440	5	+	26780180	A375	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	0.863757454803209	[]	[]	3	hSpCas9	negative selection	3981956
58458086	58458109	5	-	26780180	A375	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	1.52300523024753	[]	[]	8	hSpCas9	negative selection	3981957
58458760	58458783	5	+	26780180	A375	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.569384554921826	[]	[]	1	hSpCas9	negative selection	3981958
58458118	58458141	5	-	26780180	HT29	viability (GeCKOv2 library)	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	0.0788571339295289	[]	[]	0	hSpCas9	negative selection	4089919
58458463	58458486	5	-	26780180	HT29	viability (GeCKOv2 library)	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	1.08847542220289	[]	[]	5	hSpCas9	negative selection	4089920
58458991	58459014	5	-	26780180	HT29	viability (GeCKOv2 library)	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.337067503700853	[]	[]	0	hSpCas9	negative selection	4089921
58458417	58458440	5	+	26780180	HT29	viability (GeCKOv2 library)	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	1.27560917200054	[]	[]	6	hSpCas9	negative selection	4089922
58458086	58458109	5	-	26780180	HT29	viability (GeCKOv2 library)	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	1.66742353655723	[]	[]	8	hSpCas9	negative selection	4089923
58458760	58458783	5	+	26780180	HT29	viability (GeCKOv2 library)	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.430971212111342	[]	[]	1	hSpCas9	negative selection	4089924
58458118	58458141	5	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	-0.5167525482630945	[2]	[0,0]	-8	hSpCas9	positive selection	4161298
58458769	58458792	5	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GCAGTTTTACCACTACTTCGAGG	PLK2	ENSG00000145632	-0.41489576333345335	[3]	[1,0]	-8	hSpCas9	positive selection	4161299
58458128	58458151	5	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GTCCCCAACTTTTAGTTCCATGG	PLK2	ENSG00000145632	-0.22311467437667137	[3]	[2,1]	-5	hSpCas9	positive selection	4161300
58458760	58458783	5	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.6321748944438897	[2]	[4,0]	9	hSpCas9	positive selection	4161301
58458118	58458141	5	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	0.8212700332436772	[1]	[4,0,0,0]	5	hSpCas9	positive selection	4225320
58458769	58458792	5	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GCAGTTTTACCACTACTTCGAGG	PLK2	ENSG00000145632	0.5905786611392525	[2]	[0,3,0,1]	4	hSpCas9	positive selection	4225321
58458128	58458151	5	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GTCCCCAACTTTTAGTTCCATGG	PLK2	ENSG00000145632	0.2966972350366075	[4]	[4,4,2,0]	2	hSpCas9	positive selection	4225322
58458760	58458783	5	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	1.093761069133731	[2]	[1,2,0,3]	8	hSpCas9	positive selection	4225323
58458118	58458141	5	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	0.36578243181336156	[0]	[0,0]	7	hSpCas9	positive selection	4290840
58458991	58459014	5	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.22777178890470853	[3]	[3,2]	4	hSpCas9	positive selection	4290841
58458760	58458783	5	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.0985525633467248	[1]	[1,0]	2	hSpCas9	positive selection	4290842
58458463	58458486	5	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	0.03934080668187345	[3]	[3,2]	0	hSpCas9	positive selection	4355091
58458417	58458440	5	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.56760261935683	[2]	[1,0]	-8	hSpCas9	positive selection	4355092
58458086	58458109	5	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.26175771143411963	[2]	[1,0]	-5	hSpCas9	positive selection	4355093
58458991	58459013	5	-	27760321	OCIAML3	viability	AGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	-0.6300181722831888	[127,101]	[75,33]	-6	hSpCas9	negative selection	4428679
58459724	58459746	5	-	27760321	OCIAML3	viability	TTATCGTCGACCCCACGACTGG	PLK2	ENSG00000145632	-0.2959313476707033	[1180,1062]	[565,906]	-3	hSpCas9	negative selection	4428680
58459826	58459848	5	+	27760321	OCIAML3	viability	GGTGGCTGCGATTCCTCGGGGG	PLK2	ENSG00000145632	0.05638460945023982	[1265,1162]	[812,1214]	0	hSpCas9	negative selection	4428681
58457200	58457222	5	+	27760321	OCIAML3	viability	CGAATGATGTCATCCAAACTGG	PLK2	ENSG00000145632	-0.6736084986449348	[256,201]	[116,104]	-6	hSpCas9	negative selection	4428682
58457310	58457332	5	-	27760321	OCIAML3	viability	AGAAACTTATAGGTGCATAAGG	PLK2	ENSG00000145632	1.6405729454718458	[21,18]	[38,63]	9	hSpCas9	negative selection	4428683
58458991	58459013	5	-	27760321	OCIAML2	viability	AGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.5099379957351018	[127,101]	[94,179]	7	hSpCas9	negative selection	4512142
58459724	58459746	5	-	27760321	OCIAML2	viability	TTATCGTCGACCCCACGACTGG	PLK2	ENSG00000145632	-0.04946526208572388	[1180,1062]	[769,1015]	0	hSpCas9	negative selection	4512143
58459826	58459848	5	+	27760321	OCIAML2	viability	GGTGGCTGCGATTCCTCGGGGG	PLK2	ENSG00000145632	0.36074311547213167	[1265,1162]	[1064,1519]	5	hSpCas9	negative selection	4512144
58457200	58457222	5	+	27760321	OCIAML2	viability	CGAATGATGTCATCCAAACTGG	PLK2	ENSG00000145632	0.5100166257212627	[256,201]	[187,360]	7	hSpCas9	negative selection	4512145
58457310	58457332	5	-	27760321	OCIAML2	viability	AGAAACTTATAGGTGCATAAGG	PLK2	ENSG00000145632	-0.6460705955395305	[21,18]	[10,9]	-6	hSpCas9	negative selection	4512146
58458991	58459013	5	-	27760321	MV411	viability	AGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.777370342642139	[127,101]	[0,321]	6	hSpCas9	negative selection	4595605
58459724	58459746	5	-	27760321	MV411	viability	TTATCGTCGACCCCACGACTGG	PLK2	ENSG00000145632	0.07679869663012329	[1180,1062]	[399,1350]	0	hSpCas9	negative selection	4595606
58459826	58459848	5	+	27760321	MV411	viability	GGTGGCTGCGATTCCTCGGGGG	PLK2	ENSG00000145632	0.14275454449182723	[1265,1162]	[444,1544]	1	hSpCas9	negative selection	4595607
58457200	58457222	5	+	27760321	MV411	viability	CGAATGATGTCATCCAAACTGG	PLK2	ENSG00000145632	0.3271543578471118	[256,201]	[129,276]	2	hSpCas9	negative selection	4595608
58457310	58457332	5	-	27760321	MV411	viability	AGAAACTTATAGGTGCATAAGG	PLK2	ENSG00000145632	-3.7539405694040324	[21,18]	[0,0]	-9	hSpCas9	negative selection	4595609
58458991	58459013	5	-	27760321	HL60	viability	AGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	-0.5450061178194847	[127,101]	[63,63]	-5	hSpCas9	negative selection	4679068
58459724	58459746	5	-	27760321	HL60	viability	TTATCGTCGACCCCACGACTGG	PLK2	ENSG00000145632	-0.1716322954640832	[1180,1062]	[825,798]	-2	hSpCas9	negative selection	4679069
58459826	58459848	5	+	27760321	HL60	viability	GGTGGCTGCGATTCCTCGGGGG	PLK2	ENSG00000145632	0.33237287883497824	[1265,1162]	[1211,1287]	4	hSpCas9	negative selection	4679070
58457200	58457222	5	+	27760321	HL60	viability	CGAATGATGTCATCCAAACTGG	PLK2	ENSG00000145632	-0.5890541214205501	[256,201]	[100,147]	-6	hSpCas9	negative selection	4679071
58457310	58457332	5	-	27760321	HL60	viability	AGAAACTTATAGGTGCATAAGG	PLK2	ENSG00000145632	-2.5052966601063824	[21,18]	[0,4]	-9	hSpCas9	negative selection	4679072
58458991	58459013	5	-	27760321	HT1080	viability	AGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	2.9289449318282514	[101,79]	[268,283]	9	hSpCas9	negative selection	4762531
58459724	58459746	5	-	27760321	HT1080	viability	TTATCGTCGACCCCACGACTGG	PLK2	ENSG00000145632	-1.749039059627516	[1062,829]	[136,84]	-6	hSpCas9	negative selection	4762532
58459826	58459848	5	+	27760321	HT1080	viability	GGTGGCTGCGATTCCTCGGGGG	PLK2	ENSG00000145632	-5.577690719444295	[1162,907]	[0,16]	-8	hSpCas9	negative selection	4762533
58457200	58457222	5	+	27760321	HT1080	viability	CGAATGATGTCATCCAAACTGG	PLK2	ENSG00000145632	-3.652300343577524	[201,157]	[9,0]	-8	hSpCas9	negative selection	4762534
58457310	58457332	5	-	27760321	HT1080	viability	AGAAACTTATAGGTGCATAAGG	PLK2	ENSG00000145632	5.3808397155226055	[18,14]	[300,261]	9	hSpCas9	negative selection	4762535
58458991	58459013	5	-	27760321	HT29	viability after 7 days	AGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	-0.8793524926066794	[101,79]	[98,38,57]	-8	hSpCas9	negative selection	4845994
58459724	58459746	5	-	27760321	HT29	viability after 7 days	TTATCGTCGACCCCACGACTGG	PLK2	ENSG00000145632	-0.397367724931476	[1062,829]	[979,1015,786]	-5	hSpCas9	negative selection	4845995
58459826	58459848	5	+	27760321	HT29	viability after 7 days	GGTGGCTGCGATTCCTCGGGGG	PLK2	ENSG00000145632	-0.223025926335491	[1162,907]	[1220,1201,1012]	-3	hSpCas9	negative selection	4845996
58457200	58457222	5	+	27760321	HT29	viability after 7 days	CGAATGATGTCATCCAAACTGG	PLK2	ENSG00000145632	0.1531561860864341	[201,157]	[258,318,195]	2	hSpCas9	negative selection	4845997
58457310	58457332	5	-	27760321	HT29	viability after 7 days	AGAAACTTATAGGTGCATAAGG	PLK2	ENSG00000145632	0.6179089934194542	[18,14]	[1,23,68]	8	hSpCas9	negative selection	4845998
58458991	58459013	5	-	27760321	HT29	viability after 25 days	AGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.14402903418447655	[101,79]	[154,107,74]	1	hSpCas9	negative selection	4929457
58459724	58459746	5	-	27760321	HT29	viability after 25 days	TTATCGTCGACCCCACGACTGG	PLK2	ENSG00000145632	-0.2856382767543777	[1062,829]	[580,954,1173]	-3	hSpCas9	negative selection	4929458
58459826	58459848	5	+	27760321	HT29	viability after 25 days	GGTGGCTGCGATTCCTCGGGGG	PLK2	ENSG00000145632	0.20577624324464883	[1162,907]	[1256,1315,1544]	2	hSpCas9	negative selection	4929459
58457200	58457222	5	+	27760321	HT29	viability after 25 days	CGAATGATGTCATCCAAACTGG	PLK2	ENSG00000145632	0.2957195776837577	[201,157]	[328,208,209]	3	hSpCas9	negative selection	4929460
58457310	58457332	5	-	27760321	HT29	viability after 25 days	AGAAACTTATAGGTGCATAAGG	PLK2	ENSG00000145632	0.4605120274425243	[18,14]	[0,0,85]	5	hSpCas9	negative selection	4929461
58458991	58459013	5	-	27760321	HT29	viability after 22 days	AGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.19144574914695078	[101,79]	[144,75,138]	2	hSpCas9	negative selection	5012920
58459724	58459746	5	-	27760321	HT29	viability after 22 days	TTATCGTCGACCCCACGACTGG	PLK2	ENSG00000145632	0.07316695812969565	[1062,829]	[1026,1150,1279]	0	hSpCas9	negative selection	5012921
58459826	58459848	5	+	27760321	HT29	viability after 22 days	GGTGGCTGCGATTCCTCGGGGG	PLK2	ENSG00000145632	0.22119826303019652	[1162,907]	[1306,1566,1313]	2	hSpCas9	negative selection	5012922
58457200	58457222	5	+	27760321	HT29	viability after 22 days	CGAATGATGTCATCCAAACTGG	PLK2	ENSG00000145632	0.5190695356135544	[201,157]	[367,311,211]	6	hSpCas9	negative selection	5012923
58457310	58457332	5	-	27760321	HT29	viability after 22 days	AGAAACTTATAGGTGCATAAGG	PLK2	ENSG00000145632	-1.3717435082868086	[18,14]	[0,11,9]	-7	hSpCas9	negative selection	5012924
58458991	58459013	5	-	27760321	HT29	viability after 19 days	AGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	-1.5304439598443151	[101,79]	[58,28,22]	-7	hSpCas9	negative selection	5096383
58459724	58459746	5	-	27760321	HT29	viability after 19 days	TTATCGTCGACCCCACGACTGG	PLK2	ENSG00000145632	-0.2847893146514817	[1062,829]	[769,758,1114]	-3	hSpCas9	negative selection	5096384
58459826	58459848	5	+	27760321	HT29	viability after 19 days	GGTGGCTGCGATTCCTCGGGGG	PLK2	ENSG00000145632	0.587763974739328	[1162,907]	[1661,1450,2196]	6	hSpCas9	negative selection	5096385
58457200	58457222	5	+	27760321	HT29	viability after 19 days	CGAATGATGTCATCCAAACTGG	PLK2	ENSG00000145632	0.5496265074571969	[201,157]	[424,355,141]	5	hSpCas9	negative selection	5096386
58457310	58457332	5	-	27760321	HT29	viability after 19 days	AGAAACTTATAGGTGCATAAGG	PLK2	ENSG00000145632	-1.012492216890588	[18,14]	[4,1,20]	-6	hSpCas9	negative selection	5096387
58458991	58459013	5	-	27760321	HT29	viability after 16 days	AGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.6233349956351721	[101,79]	[157,107,205]	7	hSpCas9	negative selection	5179846
58459724	58459746	5	-	27760321	HT29	viability after 16 days	TTATCGTCGACCCCACGACTGG	PLK2	ENSG00000145632	-0.1765688275653099	[1062,829]	[1004,792,1022]	-2	hSpCas9	negative selection	5179847
58459826	58459848	5	+	27760321	HT29	viability after 16 days	GGTGGCTGCGATTCCTCGGGGG	PLK2	ENSG00000145632	0.18885886809152264	[1162,907]	[1441,1320,1209]	2	hSpCas9	negative selection	5179848
58457200	58457222	5	+	27760321	HT29	viability after 16 days	CGAATGATGTCATCCAAACTGG	PLK2	ENSG00000145632	0.7872519621237104	[201,157]	[590,221,255]	8	hSpCas9	negative selection	5179849
58457310	58457332	5	-	27760321	HT29	viability after 16 days	AGAAACTTATAGGTGCATAAGG	PLK2	ENSG00000145632	1.1860592289539023	[18,14]	[2,8,114]	9	hSpCas9	negative selection	5179850
58458991	58459013	5	-	27760321	HT29	viability after 13 days	AGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.14088984038028585	[101,79]	[86,173,89]	1	hSpCas9	negative selection	5263309
58459724	58459746	5	-	27760321	HT29	viability after 13 days	TTATCGTCGACCCCACGACTGG	PLK2	ENSG00000145632	-0.2332474250955976	[1062,829]	[890,987,923]	-3	hSpCas9	negative selection	5263310
58459826	58459848	5	+	27760321	HT29	viability after 13 days	GGTGGCTGCGATTCCTCGGGGG	PLK2	ENSG00000145632	0.4017870933899368	[1162,907]	[1628,1545,1585]	5	hSpCas9	negative selection	5263311
58457200	58457222	5	+	27760321	HT29	viability after 13 days	CGAATGATGTCATCCAAACTGG	PLK2	ENSG00000145632	0.4248553225300383	[201,157]	[301,343,199]	5	hSpCas9	negative selection	5263312
58457310	58457332	5	-	27760321	HT29	viability after 13 days	AGAAACTTATAGGTGCATAAGG	PLK2	ENSG00000145632	-0.005355968768674835	[18,14]	[2,52,3]	0	hSpCas9	negative selection	5263313
58458991	58459013	5	-	27760321	HT29	viability after 10 days	AGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.0022812804315917035	[101,79]	[165,140,36]	0	hSpCas9	negative selection	5346772
58459724	58459746	5	-	27760321	HT29	viability after 10 days	TTATCGTCGACCCCACGACTGG	PLK2	ENSG00000145632	-0.23145507104397578	[1062,829]	[990,1119,913]	-3	hSpCas9	negative selection	5346773
58459826	58459848	5	+	27760321	HT29	viability after 10 days	GGTGGCTGCGATTCCTCGGGGG	PLK2	ENSG00000145632	0.3502880926574512	[1162,907]	[1309,1831,1803]	5	hSpCas9	negative selection	5346774
58457200	58457222	5	+	27760321	HT29	viability after 10 days	CGAATGATGTCATCCAAACTGG	PLK2	ENSG00000145632	-0.046996700259525404	[201,157]	[275,117,254]	0	hSpCas9	negative selection	5346775
58457310	58457332	5	-	27760321	HT29	viability after 10 days	AGAAACTTATAGGTGCATAAGG	PLK2	ENSG00000145632	0.7648077151561181	[18,14]	[12,0,91]	9	hSpCas9	negative selection	5346776
58458991	58459013	5	-	27760321	MOLM13	viability	AGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	-1.0323284887227926	[127,101]	[57,8]	-6	hSpCas9	negative selection	5430235
58459724	58459746	5	-	27760321	MOLM13	viability	TTATCGTCGACCCCACGACTGG	PLK2	ENSG00000145632	0.4025372984275375	[1180,1062]	[601,1034]	3	hSpCas9	negative selection	5430236
58459826	58459848	5	+	27760321	MOLM13	viability	GGTGGCTGCGATTCCTCGGGGG	PLK2	ENSG00000145632	0.06740190963863513	[1265,1162]	[497,904]	0	hSpCas9	negative selection	5430237
58457200	58457222	5	+	27760321	MOLM13	viability	CGAATGATGTCATCCAAACTGG	PLK2	ENSG00000145632	0.5556169868790027	[256,201]	[167,206]	4	hSpCas9	negative selection	5430238
58457310	58457332	5	-	27760321	MOLM13	viability	AGAAACTTATAGGTGCATAAGG	PLK2	ENSG00000145632	-3.527883756576437	[21,18]	[0,0]	-9	hSpCas9	negative selection	5430239
58459001	58459024	5	+	27661255	K562	viability	GGTTTAGCTACTCTGCTGTGAGG	PLK2	ENSG00000145632	0.10366971823783677	[2014,2348]	[1993,1759]	3	dCas9-KRAB	negative selection	5502614
58459826	58459849	5	+	27661255	K562	viability	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	0.04878859602937302	[190,164]	[174,123]	1	dCas9-KRAB	negative selection	5502615
58458991	58459014	5	-	27661255	K562	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.0193899512820771	[1381,1395]	[1200,1058]	0	dCas9-KRAB	negative selection	5502616
58459993	58460016	5	-	27661255	K562	viability	GACGTGTGACCGCGCCTAGGGGG	PLK2	ENSG00000145632	0.28750500512249233	[406,628]	[539,467]	8	dCas9-KRAB	negative selection	5502617
58458118	58458141	5	-	27260156	BXPC3	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	0.9769583980615577	[3]	[6,10,4,9]	9	hSpCas9	negative selection	5563300
58458991	58459014	5	-	27260156	BXPC3	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.23260355696287727	[555]	[575,679,722,771]	5	hSpCas9	negative selection	5563301
58458760	58458783	5	+	27260156	BXPC3	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.3695397968491345	[133]	[237,156,183,132]	7	hSpCas9	negative selection	5563302
58458463	58458486	5	-	27260156	BXPC3	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.30097793647242327	[761]	[656,597,588,751]	-6	hSpCas9	negative selection	5627551
58458417	58458440	5	+	27260156	BXPC3	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.564769878511403	[306]	[183,249,209,224]	-8	hSpCas9	negative selection	5627552
58458086	58458109	5	-	27260156	BXPC3	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.15036236284377225	[221]	[250,168,242,164]	-3	hSpCas9	negative selection	5627553
58458118	58458141	5	-	27260156	A673	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	0.649274728760572	[3]	[5,4,10,7]	9	hSpCas9	negative selection	5684551
58458991	58459014	5	-	27260156	A673	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.3543808655926599	[555]	[823,711,948,930]	7	hSpCas9	negative selection	5684552
58458760	58458783	5	+	27260156	A673	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.4227762738484009	[133]	[189,206,206,257]	8	hSpCas9	negative selection	5684553
58458463	58458486	5	-	27260156	A673	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.29758129507253	[761]	[784,626,785,787]	-6	hSpCas9	negative selection	5748802
58458417	58458440	5	+	27260156	A673	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.19525622705607537	[306]	[331,365,277,310]	-5	hSpCas9	negative selection	5748803
58458086	58458109	5	-	27260156	A673	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.4864844774749033	[221]	[247,142,195,180]	-8	hSpCas9	negative selection	5748804
58458118	58458141	5	-	27260156	A375	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	0.24041452014007358	[3]	[0,0,0,16]	3	hSpCas9	negative selection	5805802
58458991	58459014	5	-	27260156	A375	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	-0.24147335443411072	[555]	[516,958,421,374]	-3	hSpCas9	negative selection	5805803
58458760	58458783	5	+	27260156	A375	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.5377244987786578	[133]	[203,340,182,198]	7	hSpCas9	negative selection	5805804
58458463	58458486	5	-	27260156	A375	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.2581183541079857	[761]	[732,849,757,657]	-4	hSpCas9	negative selection	5870053
58458417	58458440	5	+	27260156	A375	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.5833912716456233	[306]	[324,237,202,195]	-7	hSpCas9	negative selection	5870054
58458086	58458109	5	-	27260156	A375	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.535690390078184	[221]	[133,187,198,192]	-6	hSpCas9	negative selection	5870055
58458118	58458141	5	-	27260156	COLO741	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	-2.3524737808476335	[3]	[0,0,0]	-9	hSpCas9	negative selection	5927053
58458991	58459014	5	-	27260156	COLO741	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	-0.009547802958638024	[555]	[630,808,671]	0	hSpCas9	negative selection	5927054
58458760	58458783	5	+	27260156	COLO741	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	-0.28804774325465665	[133]	[194,132,99]	-6	hSpCas9	negative selection	5927055
58458463	58458486	5	-	27260156	COLO741	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.2314914456564598	[761]	[1026,752,729]	-5	hSpCas9	negative selection	5991304
58458417	58458440	5	+	27260156	COLO741	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.41572341366729093	[306]	[313,286,282]	-7	hSpCas9	negative selection	5991305
58458086	58458109	5	-	27260156	COLO741	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.4006491759529742	[221]	[255,224,169]	-7	hSpCas9	negative selection	5991306
58458118	58458141	5	-	27260156	CAL120	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	2.5976262867333038	[3]	[63,30,0]	9	hSpCas9	negative selection	6048304
58458991	58459014	5	-	27260156	CAL120	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.6275152413887184	[555]	[1418,888,952]	8	hSpCas9	negative selection	6048305
58458760	58458783	5	+	27260156	CAL120	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.7633775596463357	[133]	[514,145,223]	9	hSpCas9	negative selection	6048306
58458463	58458486	5	-	27260156	CAL120	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.14585956409307577	[761]	[932,780,867]	-2	hSpCas9	negative selection	6112555
58458417	58458440	5	+	27260156	CAL120	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	0.145788286484272	[306]	[482,602,194]	2	hSpCas9	negative selection	6112556
58458086	58458109	5	-	27260156	CAL120	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.47747439034396977	[221]	[197,248,148]	-6	hSpCas9	negative selection	6112557
58458118	58458141	5	-	27260156	CADOES1	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	0.7521537819748678	[3]	[12,5,0,4]	9	hSpCas9	negative selection	6169555
58458991	58459014	5	-	27260156	CADOES1	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.419199162800187	[555]	[789,489,798,685]	7	hSpCas9	negative selection	6169556
58458760	58458783	5	+	27260156	CADOES1	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.8251313436098727	[133]	[245,249,171,214]	9	hSpCas9	negative selection	6169557
58458463	58458486	5	-	27260156	CADOES1	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.24894565667459906	[761]	[560,691,684,441]	-4	hSpCas9	negative selection	6233806
58458417	58458440	5	+	27260156	CADOES1	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	0.3673245789727836	[306]	[535,373,242,317]	6	hSpCas9	negative selection	6233807
58458086	58458109	5	-	27260156	CADOES1	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.4477082979643565	[221]	[157,171,138,135]	-7	hSpCas9	negative selection	6233808
58458118	58458141	5	-	27260156	EWS502	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	1.1810643493200015	[3]	[8,9,0,18]	9	hSpCas9	negative selection	6290806
58458991	58459014	5	-	27260156	EWS502	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.2615205342788556	[555]	[456,768,688,950]	4	hSpCas9	negative selection	6290807
58458760	58458783	5	+	27260156	EWS502	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.17576269022245583	[133]	[200,178,61,193]	3	hSpCas9	negative selection	6290808
58458463	58458486	5	-	27260156	EWS502	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.26506603765275083	[761]	[592,676,854,562]	-5	hSpCas9	negative selection	6355057
58458417	58458440	5	+	27260156	EWS502	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.09200015789476745	[306]	[164,286,342,452]	-2	hSpCas9	negative selection	6355058
58458086	58458109	5	-	27260156	EWS502	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.7980522638508749	[221]	[116,112,164,149]	-8	hSpCas9	negative selection	6355059
58458118	58458141	5	-	27260156	EW8	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	-1.1199039018073318	[3]	[0,2,0,0]	-9	hSpCas9	negative selection	6412057
58458991	58459014	5	-	27260156	EW8	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.2777733989979483	[555]	[579,571,302,772]	5	hSpCas9	negative selection	6412058
58458760	58458783	5	+	27260156	EW8	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.28146813029986517	[133]	[188,108,58,188]	5	hSpCas9	negative selection	6412059
58458463	58458486	5	-	27260156	EW8	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	0.06881157891018941	[761]	[569,612,628,770]	1	hSpCas9	negative selection	6476308
58458417	58458440	5	+	27260156	EW8	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.1823929726726783	[306]	[219,220,197,240]	-3	hSpCas9	negative selection	6476309
58458086	58458109	5	-	27260156	EW8	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.3650051862897352	[221]	[169,107,160,118]	-6	hSpCas9	negative selection	6476310
58458118	58458141	5	-	27260156	CORL105	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	1.5521445418724609	[3]	[18,3,11,19]	9	hSpCas9	negative selection	6533308
58458991	58459014	5	-	27260156	CORL105	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.5930383878829119	[555]	[1233,785,1339,636]	9	hSpCas9	negative selection	6533309
58458760	58458783	5	+	27260156	CORL105	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.1003676121362489	[133]	[150,130,245,156]	1	hSpCas9	negative selection	6533310
58458463	58458486	5	-	27260156	CORL105	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.632812869245329	[761]	[623,662,571,441]	-8	hSpCas9	negative selection	6597559
58458417	58458440	5	+	27260156	CORL105	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.8770751240904591	[306]	[168,138,304,186]	-9	hSpCas9	negative selection	6597560
58458086	58458109	5	-	27260156	CORL105	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.633215358660431	[221]	[173,194,179,122]	-8	hSpCas9	negative selection	6597561
58458118	58458141	5	-	27260156	HS294T	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	1.2299815574015645	[3]	[1,9,0,0]	9	hSpCas9	negative selection	6654559
58458991	58459014	5	-	27260156	HS294T	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.35708457392632664	[555]	[314,271,247,258]	5	hSpCas9	negative selection	6654560
58458760	58458783	5	+	27260156	HS294T	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.8206868486410012	[133]	[162,86,36,67]	9	hSpCas9	negative selection	6654561
58458463	58458486	5	-	27260156	HS294T	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.35255955025016605	[761]	[156,277,240,255]	-5	hSpCas9	negative selection	6718810
58458417	58458440	5	+	27260156	HS294T	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.40014817061806496	[306]	[99,80,56,126]	-5	hSpCas9	negative selection	6718811
58458086	58458109	5	-	27260156	HS294T	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	0.08511337843647848	[221]	[166,51,51,85]	1	hSpCas9	negative selection	6718812
58458118	58458141	5	-	27260156	HCC44	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	-0.026918378471362026	[3]	[11,3,0,0]	0	hSpCas9	negative selection	6775810
58458991	58459014	5	-	27260156	HCC44	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	-0.05462596986438628	[555]	[631,416,694,713]	-1	hSpCas9	negative selection	6775811
58458760	58458783	5	+	27260156	HCC44	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.001252581076858661	[133]	[184,151,118,146]	0	hSpCas9	negative selection	6775812
58458463	58458486	5	-	27260156	HCC44	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.4588192104572203	[761]	[477,493,926,659]	-6	hSpCas9	negative selection	6840061
58458417	58458440	5	+	27260156	HCC44	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	0.12399578573548375	[306]	[203,376,495,435]	2	hSpCas9	negative selection	6840062
58458086	58458109	5	-	27260156	HCC44	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.1480923119984332	[221]	[144,208,243,301]	-2	hSpCas9	negative selection	6840063
58458118	58458141	5	-	27260156	G402	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	1.5479490914845604	[3]	[0,0,51,0]	9	hSpCas9	negative selection	6897061
58458991	58459014	5	-	27260156	G402	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.45346014311990857	[555]	[843,1230,996,658]	5	hSpCas9	negative selection	6897062
58458760	58458783	5	+	27260156	G402	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.9730894706987948	[133]	[210,336,362,354]	9	hSpCas9	negative selection	6897063
58458463	58458486	5	-	27260156	G402	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.05480838879663252	[761]	[882,912,538,1224]	0	hSpCas9	negative selection	6961312
58458417	58458440	5	+	27260156	G402	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.9785368519948863	[306]	[214,166,190,188]	-8	hSpCas9	negative selection	6961313
58458086	58458109	5	-	27260156	G402	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-1.2493787191599133	[221]	[138,61,78,172]	-8	hSpCas9	negative selection	6961314
58458118	58458141	5	-	27260156	L33	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	-0.26859122269479574	[3]	[0,3,0,0]	-6	hSpCas9	negative selection	7018312
58458991	58459014	5	-	27260156	L33	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.381761848853268	[555]	[779,309,441,656]	7	hSpCas9	negative selection	7018313
58458760	58458783	5	+	27260156	L33	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.258822012297772	[133]	[154,106,71,110]	5	hSpCas9	negative selection	7018314
58458463	58458486	5	-	27260156	L33	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.49753436728218187	[761]	[492,252,360,475]	-8	hSpCas9	negative selection	7082563
58458417	58458440	5	+	27260156	L33	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.23581741354533425	[306]	[203,154,120,268]	-5	hSpCas9	negative selection	7082564
58458086	58458109	5	-	27260156	L33	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.03944431537558102	[221]	[277,112,62,207]	-1	hSpCas9	negative selection	7082565
58458118	58458141	5	-	27260156	K562	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	-1.8261501679237142	[3]	[0,0,0,0]	-9	hSpCas9	negative selection	7139563
58458991	58459014	5	-	27260156	K562	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.12900293639843563	[555]	[518,620,605,425]	1	hSpCas9	negative selection	7139564
58458760	58458783	5	+	27260156	K562	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	1.2641308299866552	[133]	[192,200,673,84]	9	hSpCas9	negative selection	7139565
58458463	58458486	5	-	27260156	K562	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.3676747407379274	[761]	[517,575,540,467]	-4	hSpCas9	negative selection	7203814
58458417	58458440	5	+	27260156	K562	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	0.5437864753737449	[306]	[279,172,558,536]	7	hSpCas9	negative selection	7203815
58458086	58458109	5	-	27260156	K562	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	0.0021956914754919232	[221]	[293,287,105,121]	0	hSpCas9	negative selection	7203816
58458118	58458141	5	-	27260156	HT29	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	-2.2790189480051524	[3]	[0,0,0,0]	-9	hSpCas9	negative selection	7260814
58458991	58459014	5	-	27260156	HT29	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.2384331095137624	[555]	[753,974,682,784]	4	hSpCas9	negative selection	7260815
58458760	58458783	5	+	27260156	HT29	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.12672642432250947	[133]	[188,131,216,169]	2	hSpCas9	negative selection	7260816
58458463	58458486	5	-	27260156	HT29	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.13636889387646256	[761]	[897,1085,760,666]	-3	hSpCas9	negative selection	7325065
58458417	58458440	5	+	27260156	HT29	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.2222387321160909	[306]	[389,321,269,302]	-4	hSpCas9	negative selection	7325066
58458086	58458109	5	-	27260156	HT29	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.2773305239591186	[221]	[283,213,216,182]	-5	hSpCas9	negative selection	7325067
58458118	58458141	5	-	27260156	MHHES1	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	-0.3135486167001593	[3]	[2,0,5,3]	-5	hSpCas9	negative selection	7382065
58458991	58459014	5	-	27260156	MHHES1	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.42326611042816664	[555]	[1067,909,978,498]	7	hSpCas9	negative selection	7382066
58458760	58458783	5	+	27260156	MHHES1	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.12824263795390167	[133]	[322,111,164,87]	2	hSpCas9	negative selection	7382067
58458463	58458486	5	-	27260156	MHHES1	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.25328081001791636	[761]	[726,974,742,497]	-5	hSpCas9	negative selection	7446316
58458417	58458440	5	+	27260156	MHHES1	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.19610143011183634	[306]	[261,356,386,215]	-4	hSpCas9	negative selection	7446317
58458086	58458109	5	-	27260156	MHHES1	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.6938815832778766	[221]	[129,169,126,179]	-8	hSpCas9	negative selection	7446318
58458118	58458141	5	-	27260156	MEWO	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	-0.388434550174626	[3]	[4,0,2]	-7	hSpCas9	negative selection	7503316
58458991	58459014	5	-	27260156	MEWO	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.07011742927571363	[555]	[658,543,456]	1	hSpCas9	negative selection	7503317
58458760	58458783	5	+	27260156	MEWO	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.29312987570999716	[133]	[241,136,98]	6	hSpCas9	negative selection	7503318
58458463	58458486	5	-	27260156	MEWO	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.3578370434257738	[761]	[712,582,402]	-7	hSpCas9	negative selection	7567567
58458417	58458440	5	+	27260156	MEWO	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.30586346343580506	[306]	[380,188,155]	-6	hSpCas9	negative selection	7567568
58458086	58458109	5	-	27260156	MEWO	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.4599186949255749	[221]	[104,161,176]	-7	hSpCas9	negative selection	7567569
58458118	58458141	5	-	27260156	LNCAPCLONEFGC	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	2.1090548228136257	[3]	[0,46,3,6]	9	hSpCas9	negative selection	7624567
58458991	58459014	5	-	27260156	LNCAPCLONEFGC	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	-0.17179896488693105	[555]	[410,405,631,369]	-3	hSpCas9	negative selection	7624568
58458760	58458783	5	+	27260156	LNCAPCLONEFGC	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.5928821328981668	[133]	[207,188,153,175]	8	hSpCas9	negative selection	7624569
58458463	58458486	5	-	27260156	LNCAPCLONEFGC	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.1148712524522012	[761]	[641,596,799,536]	-2	hSpCas9	negative selection	7688818
58458417	58458440	5	+	27260156	LNCAPCLONEFGC	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.5425229948385155	[306]	[162,180,198,222]	-7	hSpCas9	negative selection	7688819
58458086	58458109	5	-	27260156	LNCAPCLONEFGC	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.6222690198553542	[221]	[101,80,242,116]	-7	hSpCas9	negative selection	7688820
58458118	58458141	5	-	27260156	PANC0327	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	-0.00621692249350847	[3]	[3,4,2,1]	0	hSpCas9	negative selection	7745818
58458991	58459014	5	-	27260156	PANC0327	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.33142591182069925	[555]	[865,657,565,410]	5	hSpCas9	negative selection	7745819
58458760	58458783	5	+	27260156	PANC0327	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.8188776329890952	[133]	[186,98,126,438]	9	hSpCas9	negative selection	7745820
58458463	58458486	5	-	27260156	PANC0327	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	0.03985450478706687	[761]	[828,681,708,575]	0	hSpCas9	negative selection	7810069
58458417	58458440	5	+	27260156	PANC0327	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	0.6324689542247606	[306]	[508,467,324,389]	8	hSpCas9	negative selection	7810070
58458086	58458109	5	-	27260156	PANC0327	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	0.7434887141227439	[221]	[562,108,256,438]	9	hSpCas9	negative selection	7810071
58458118	58458141	5	-	27260156	NCIH2009	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	0.276652750232099	[3]	[19,1,0]	4	hSpCas9	negative selection	7867069
58458991	58459014	5	-	27260156	NCIH2009	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.04919550273946666	[555]	[1095,841,528]	0	hSpCas9	negative selection	7867070
58458760	58458783	5	+	27260156	NCIH2009	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.6896539865455587	[133]	[220,432,232]	8	hSpCas9	negative selection	7867071
58458463	58458486	5	-	27260156	NCIH2009	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.3224862625805336	[761]	[1005,809,767]	-4	hSpCas9	negative selection	7931320
58458417	58458440	5	+	27260156	NCIH2009	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.3179610873261496	[306]	[260,357,395]	-4	hSpCas9	negative selection	7931321
58458086	58458109	5	-	27260156	NCIH2009	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.6699895778550984	[221]	[133,164,273]	-7	hSpCas9	negative selection	7931322
58458118	58458141	5	-	27260156	NCIH1373	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	-1.4198903640528862	[3]	[0,0,0,0]	-8	hSpCas9	negative selection	7988320
58458991	58459014	5	-	27260156	NCIH1373	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.25383032258165816	[555]	[858,1019,465,159]	2	hSpCas9	negative selection	7988321
58458760	58458783	5	+	27260156	NCIH1373	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	1.4260141149600944	[133]	[553,187,353,150]	9	hSpCas9	negative selection	7988322
58458463	58458486	5	-	27260156	NCIH1373	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	0.02201308091174381	[761]	[1011,847,675,252]	0	hSpCas9	negative selection	8052571
58458417	58458440	5	+	27260156	NCIH1373	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.2813719755963143	[306]	[201,383,236,74]	-3	hSpCas9	negative selection	8052572
58458086	58458109	5	-	27260156	NCIH1373	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-1.272747866998744	[221]	[126,88,62,36]	-8	hSpCas9	negative selection	8052573
58458118	58458141	5	-	27260156	PATU8902	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	0.5821914487916198	[3]	[30,0,0,0]	6	hSpCas9	negative selection	8109571
58458991	58459014	5	-	27260156	PATU8902	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.28946864891244595	[555]	[982,551,738,1638]	3	hSpCas9	negative selection	8109572
58458760	58458783	5	+	27260156	PATU8902	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	1.0342867856846687	[133]	[289,612,325,303]	9	hSpCas9	negative selection	8109573
58458463	58458486	5	-	27260156	PATU8902	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.2728430719453794	[761]	[840,728,935,999]	-3	hSpCas9	negative selection	8173822
58458417	58458440	5	+	27260156	PATU8902	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.353862080932289	[306]	[320,262,145,697]	-4	hSpCas9	negative selection	8173823
58458086	58458109	5	-	27260156	PATU8902	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.9145211502093926	[221]	[59,148,224,211]	-7	hSpCas9	negative selection	8173824
58458118	58458141	5	-	27260156	PANC1	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	1.577505458692567	[3]	[3,36,5,0]	9	hSpCas9	negative selection	8230822
58458991	58459014	5	-	27260156	PANC1	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.33455224485641777	[555]	[477,730,656,567]	5	hSpCas9	negative selection	8230823
58458760	58458783	5	+	27260156	PANC1	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.6377766387287962	[133]	[266,246,56,156]	9	hSpCas9	negative selection	8230824
58458463	58458486	5	-	27260156	PANC1	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	0.17029705556748143	[761]	[707,1052,689,574]	2	hSpCas9	negative selection	8295073
58458417	58458440	5	+	27260156	PANC1	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.09972068742203477	[306]	[318,196,277,184]	-2	hSpCas9	negative selection	8295074
58458086	58458109	5	-	27260156	PANC1	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.31342398066065624	[221]	[152,153,181,126]	-5	hSpCas9	negative selection	8295075
58458118	58458141	5	-	27260156	PANC0813	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	1.42500945451145	[3]	[44,3,2,1]	9	hSpCas9	negative selection	8352073
58458991	58459014	5	-	27260156	PANC0813	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.22270165928434	[555]	[885,634,847,693]	3	hSpCas9	negative selection	8352074
58458760	58458783	5	+	27260156	PANC0813	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.6528761996839902	[133]	[151,226,470,137]	9	hSpCas9	negative selection	8352075
58458463	58458486	5	-	27260156	PANC0813	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.2493411831800702	[761]	[707,752,692,846]	-4	hSpCas9	negative selection	8416324
58458417	58458440	5	+	27260156	PANC0813	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.1687991200073854	[306]	[507,291,224,276]	-3	hSpCas9	negative selection	8416325
58458086	58458109	5	-	27260156	PANC0813	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.27635626741155916	[221]	[139,195,90,414]	-4	hSpCas9	negative selection	8416326
58458118	58458141	5	-	27260156	RDES	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	0.8132161407926173	[3]	[8,15,1,2]	9	hSpCas9	negative selection	8473324
58458991	58459014	5	-	27260156	RDES	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.03196893735175499	[555]	[602,569,622,844]	0	hSpCas9	negative selection	8473325
58458760	58458783	5	+	27260156	RDES	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.5222408042517537	[133]	[169,234,233,254]	8	hSpCas9	negative selection	8473326
58458463	58458486	5	-	27260156	RDES	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.37876584204867453	[761]	[603,660,646,795]	-6	hSpCas9	negative selection	8537575
58458417	58458440	5	+	27260156	RDES	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	0.23866222041707397	[306]	[374,441,288,571]	4	hSpCas9	negative selection	8537576
58458086	58458109	5	-	27260156	RDES	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.5230231676452306	[221]	[150,179,213,164]	-7	hSpCas9	negative selection	8537577
58458118	58458141	5	-	27260156	PC3	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	0.9202438686949961	[3]	[6,7,3,8]	9	hSpCas9	negative selection	8594575
58458991	58459014	5	-	27260156	PC3	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.0726651279781867	[555]	[329,701,1008,503]	1	hSpCas9	negative selection	8594576
58458760	58458783	5	+	27260156	PC3	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	-0.12432015004849784	[133]	[45,121,238,155]	-3	hSpCas9	negative selection	8594577
58458463	58458486	5	-	27260156	PC3	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.0037516253578828707	[761]	[398,674,1383,922]	0	hSpCas9	negative selection	8658826
58458417	58458440	5	+	27260156	PC3	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.48862980598014105	[306]	[153,178,371,234]	-8	hSpCas9	negative selection	8658827
58458086	58458109	5	-	27260156	PC3	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.024188359306981377	[221]	[157,118,541,184]	0	hSpCas9	negative selection	8658828
58458118	58458141	5	-	27260156	PATU8988T	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	-1.9504748017735896	[3]	[0,0,0,0]	-9	hSpCas9	negative selection	8715826
58458991	58459014	5	-	27260156	PATU8988T	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.09557662639317127	[555]	[711,568,505,503]	1	hSpCas9	negative selection	8715827
58458760	58458783	5	+	27260156	PATU8988T	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.32184822830839455	[133]	[201,164,111,169]	5	hSpCas9	negative selection	8715828
58458463	58458486	5	-	27260156	PATU8988T	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.2044667463925941	[761]	[644,546,727,624]	-3	hSpCas9	negative selection	8780077
58458417	58458440	5	+	27260156	PATU8988T	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.47214067572017426	[306]	[257,156,210,224]	-6	hSpCas9	negative selection	8780078
58458086	58458109	5	-	27260156	PATU8988T	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	0.30723285381516374	[221]	[223,414,93,351]	5	hSpCas9	negative selection	8780079
58458118	58458141	5	-	27260156	T47D	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	-0.16197093513633654	[3]	[6,1,0,6]	-4	hSpCas9	negative selection	8837077
58458991	58459014	5	-	27260156	T47D	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.1862001659239086	[555]	[872,687,629,763]	4	hSpCas9	negative selection	8837078
58458760	58458783	5	+	27260156	T47D	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.2864379425624417	[133]	[217,189,144,209]	6	hSpCas9	negative selection	8837079
58458463	58458486	5	-	27260156	T47D	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.3355819717514239	[761]	[634,776,593,805]	-6	hSpCas9	negative selection	8901328
58458417	58458440	5	+	27260156	T47D	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.23625025398057753	[306]	[294,294,317,306]	-5	hSpCas9	negative selection	8901329
58458086	58458109	5	-	27260156	T47D	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.4490337551265837	[221]	[161,222,156,213]	-7	hSpCas9	negative selection	8901330
58458118	58458141	5	-	27260156	SU8686	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	-1.9848967362596301	[3]	[0,0,0,0]	-9	hSpCas9	negative selection	8958328
58458991	58459014	5	-	27260156	SU8686	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.5275220180202561	[555]	[601,801,926,879]	8	hSpCas9	negative selection	8958329
58458760	58458783	5	+	27260156	SU8686	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.3720969481196592	[133]	[131,67,288,227]	6	hSpCas9	negative selection	8958330
58458463	58458486	5	-	27260156	SU8686	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.2725445162463464	[761]	[592,478,718,751]	-4	hSpCas9	negative selection	9022579
58458417	58458440	5	+	27260156	SU8686	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.26599991462656647	[306]	[285,226,255,238]	-4	hSpCas9	negative selection	9022580
58458086	58458109	5	-	27260156	SU8686	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.18700998616687414	[221]	[228,188,126,226]	-3	hSpCas9	negative selection	9022581
58458118	58458141	5	-	27260156	SKES1	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	1.0933156029648803	[3]	[3,3,8,14]	9	hSpCas9	negative selection	9079579
58458991	58459014	5	-	27260156	SKES1	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.2062252515425138	[555]	[736,833,538,497]	4	hSpCas9	negative selection	9079580
58458760	58458783	5	+	27260156	SKES1	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.15734428223485408	[133]	[211,216,95,93]	3	hSpCas9	negative selection	9079581
58458463	58458486	5	-	27260156	SKES1	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.11004570696039806	[761]	[668,672,864,603]	-2	hSpCas9	negative selection	9143830
58458417	58458440	5	+	27260156	SKES1	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.43354798894220625	[306]	[174,384,195,167]	-7	hSpCas9	negative selection	9143831
58458086	58458109	5	-	27260156	SKES1	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.30041939859367384	[221]	[250,163,151,160]	-6	hSpCas9	negative selection	9143832
58458118	58458141	5	-	27260156	TOV112D	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	-0.04424867424300505	[3]	[4,0,7,0]	-1	hSpCas9	negative selection	9200830
58458991	58459014	5	-	27260156	TOV112D	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	-0.13101795705070385	[555]	[646,407,450,513]	-3	hSpCas9	negative selection	9200831
58458760	58458783	5	+	27260156	TOV112D	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.19315318434424666	[133]	[157,155,128,170]	4	hSpCas9	negative selection	9200832
58458463	58458486	5	-	27260156	TOV112D	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.19267744044004886	[761]	[744,648,832,450]	-4	hSpCas9	negative selection	9265081
58458417	58458440	5	+	27260156	TOV112D	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.34149844532620266	[306]	[303,294,207,182]	-6	hSpCas9	negative selection	9265082
58458086	58458109	5	-	27260156	TOV112D	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	0.01774447622661235	[221]	[184,275,180,265]	0	hSpCas9	negative selection	9265083
58458118	58458141	5	-	27260156	TC71	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	1.2478863612255822	[3]	[21,0,2,14]	9	hSpCas9	negative selection	9322081
58458991	58459014	5	-	27260156	TC71	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.18891868756782748	[555]	[657,614,754,687]	5	hSpCas9	negative selection	9322082
58458760	58458783	5	+	27260156	TC71	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.4014699090042544	[133]	[150,240,129,242]	8	hSpCas9	negative selection	9322083
58458463	58458486	5	-	27260156	TC71	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.22811415854534495	[761]	[706,749,677,651]	-6	hSpCas9	negative selection	9386332
58458417	58458440	5	+	27260156	TC71	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	-0.11310445937916347	[306]	[331,351,258,272]	-3	hSpCas9	negative selection	9386333
58458086	58458109	5	-	27260156	TC71	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.2445507871389756	[221]	[204,168,122,315]	-6	hSpCas9	negative selection	9386334
58458118	58458141	5	-	27260156	TC32	viability	AAAAGTTGGGGACTTCGGTCTGG	PLK2	ENSG00000145632	1.6102933275823252	[3]	[1,0,25,24]	9	hSpCas9	negative selection	9443332
58458991	58459014	5	-	27260156	TC32	viability	GAGTAGCTAAACCTCATCAAAGG	PLK2	ENSG00000145632	0.16614184670543874	[555]	[649,392,687,665]	3	hSpCas9	negative selection	9443333
58458760	58458783	5	+	27260156	TC32	viability	TTTCTTTGTCCTCGAAGTAGTGG	PLK2	ENSG00000145632	0.6733032075502792	[133]	[130,190,269,224]	9	hSpCas9	negative selection	9443334
58458463	58458486	5	-	27260156	TC32	viability	CAGAAGTTCGATACTACCTCAGG	PLK2	ENSG00000145632	-0.1902448446806796	[761]	[595,421,765,805]	-3	hSpCas9	negative selection	9507583
58458417	58458440	5	+	27260156	TC32	viability	GCAAGATTTCTTGTTCATGAAGG	PLK2	ENSG00000145632	0.005765039355843937	[306]	[316,215,399,248]	0	hSpCas9	negative selection	9507584
58458086	58458109	5	-	27260156	TC32	viability	TAGAACCCTTGGAACACAGAAGG	PLK2	ENSG00000145632	-0.5038890497366046	[221]	[119,138,141,185]	-7	hSpCas9	negative selection	9507585
58454963	58454986	5	+	27869803	HPAFII	viability after 27 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	0.20100244341232298	[649]	[478,320,NaN]	1	hSpCas9	negative selection	9592215
58455643	58455666	5	-	27869803	HPAFII	viability after 27 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	-0.6987935410300485	[150]	[73,27,NaN]	-5	hSpCas9	negative selection	9592216
58456105	58456128	5	+	27869803	HPAFII	viability after 27 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	-0.4575038228015127	[363]	[140,137,NaN]	-3	hSpCas9	negative selection	9592217
58457530	58457553	5	-	27869803	HPAFII	viability after 27 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	0.23276787591964831	[787]	[344,604,NaN]	1	hSpCas9	negative selection	9592218
58458081	58458104	5	+	27869803	HPAFII	viability after 27 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	-0.0034721919068054774	[64]	[38,29,NaN]	0	hSpCas9	negative selection	9592219
58459826	58459849	5	+	27869803	HPAFII	viability after 27 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	-0.35465816235524183	[43]	[22,13,NaN]	-3	hSpCas9	negative selection	9592220
58454963	58454986	5	+	27869803	HPAFII	viability after 15 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	0.1459917592874771	[649]	[1293,448,NaN]	1	hSpCas9	negative selection	9674664
58455643	58455666	5	-	27869803	HPAFII	viability after 15 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	-0.37518841407067427	[150]	[179,90,NaN]	-4	hSpCas9	negative selection	9674665
58456105	58456128	5	+	27869803	HPAFII	viability after 15 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	-0.3195367301044446	[363]	[458,222,NaN]	-4	hSpCas9	negative selection	9674666
58457530	58457553	5	-	27869803	HPAFII	viability after 15 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	0.10000015168955345	[787]	[956,876,NaN]	1	hSpCas9	negative selection	9674667
58458081	58458104	5	+	27869803	HPAFII	viability after 15 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	0.4256955693656821	[64]	[99,89,NaN]	5	hSpCas9	negative selection	9674668
58459826	58459849	5	+	27869803	HPAFII	viability after 15 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	0.821762900348195	[43]	[98,73,NaN]	8	hSpCas9	negative selection	9674669
58454963	58454986	5	+	27869803	ASPC1	viability after 36 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	0.6232886691004103	[1498]	[935,1036,522]	6	hSpCas9	negative selection	9757113
58455643	58455666	5	-	27869803	ASPC1	viability after 36 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	0.1700530675184332	[385]	[338,116,45]	1	hSpCas9	negative selection	9757114
58456105	58456128	5	+	27869803	ASPC1	viability after 36 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	0.39975688025587097	[1129]	[493,656,424]	4	hSpCas9	negative selection	9757115
58457530	58457553	5	-	27869803	ASPC1	viability after 36 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	0.2356249631643763	[1747]	[984,648,578]	2	hSpCas9	negative selection	9757116
58458081	58458104	5	+	27869803	ASPC1	viability after 36 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	1.4733467000465756	[179]	[65,255,183]	9	hSpCas9	negative selection	9757117
58459826	58459849	5	+	27869803	ASPC1	viability after 36 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	0.14620797217922665	[237]	[31,62,155]	1	hSpCas9	negative selection	9757118
58454963	58454986	5	+	27869803	PATU8988S	viability after 35 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	1.1213487235845758	[1235]	[1285,878,NaN]	9	hSpCas9	negative selection	9839562
58455643	58455666	5	-	27869803	PATU8988S	viability after 35 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	0.6642879590638939	[336]	[257,171,NaN]	7	hSpCas9	negative selection	9839563
58456105	58456128	5	+	27869803	PATU8988S	viability after 35 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	0.5419026160992072	[945]	[859,247,NaN]	6	hSpCas9	negative selection	9839564
58457530	58457553	5	-	27869803	PATU8988S	viability after 35 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	0.38163879310082405	[1647]	[743,985,NaN]	4	hSpCas9	negative selection	9839565
58458081	58458104	5	+	27869803	PATU8988S	viability after 35 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	-0.19058566599872817	[247]	[96,77,NaN]	-2	hSpCas9	negative selection	9839566
58459826	58459849	5	+	27869803	PATU8988S	viability after 35 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	0.23808543505147273	[159]	[76,74,NaN]	2	hSpCas9	negative selection	9839567
58454963	58454986	5	+	27869803	PATU8988S	viability after 31 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	1.0347161262471396	[1235]	[1109,881,NaN]	9	hSpCas9	negative selection	9922011
58455643	58455666	5	-	27869803	PATU8988S	viability after 31 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	0.5623878312173212	[336]	[175,226,NaN]	6	hSpCas9	negative selection	9922012
58456105	58456128	5	+	27869803	PATU8988S	viability after 31 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	0.9469693103562914	[945]	[896,510,NaN]	9	hSpCas9	negative selection	9922013
58457530	58457553	5	-	27869803	PATU8988S	viability after 31 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	0.3891406053873492	[1647]	[593,1199,NaN]	5	hSpCas9	negative selection	9922014
58458081	58458104	5	+	27869803	PATU8988S	viability after 31 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	-0.37451676628661956	[247]	[70,82,NaN]	-4	hSpCas9	negative selection	9922015
58459826	58459849	5	+	27869803	PATU8988S	viability after 31 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	0.9310872340563827	[159]	[151,82,NaN]	9	hSpCas9	negative selection	9922016
58454963	58454986	5	+	27869803	HPAFII	viability after 35 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	0.578753234271195	[649]	[371,625,NaN]	4	hSpCas9	negative selection	10004460
58455643	58455666	5	-	27869803	HPAFII	viability after 35 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	-0.3406139100377381	[150]	[89,26,NaN]	-2	hSpCas9	negative selection	10004461
58456105	58456128	5	+	27869803	HPAFII	viability after 35 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	-1.2969634300688755	[363]	[66,83,NaN]	-6	hSpCas9	negative selection	10004462
58457530	58457553	5	-	27869803	HPAFII	viability after 35 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	0.5420089922720461	[787]	[355,833,NaN]	3	hSpCas9	negative selection	10004463
58458081	58458104	5	+	27869803	HPAFII	viability after 35 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	0.00928952427501617	[64]	[34,30,NaN]	0	hSpCas9	negative selection	10004464
58459826	58459849	5	+	27869803	HPAFII	viability after 35 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	-0.3702242206706434	[43]	[12,21,NaN]	-2	hSpCas9	negative selection	10004465
58454963	58454986	5	+	27869803	HPAFII	viability after 31 days	CACTGAAGGAGGTAGAGCCGAGG	PLK2	ENSG00000145632	0.2125412147884964	[649]	[359,490,NaN]	1	hSpCas9	negative selection	10086909
58455643	58455666	5	-	27869803	HPAFII	viability after 31 days	CATTTCAGTGGGTCACCAAATGG	PLK2	ENSG00000145632	-0.12214369077100218	[150]	[85,68,NaN]	-1	hSpCas9	negative selection	10086910
58456105	58456128	5	+	27869803	HPAFII	viability after 31 days	TACTGCGGGTGTTCCAGACCTGG	PLK2	ENSG00000145632	-0.48128533817679015	[363]	[97,198,NaN]	-3	hSpCas9	negative selection	10086911
58457530	58457553	5	-	27869803	HPAFII	viability after 31 days	CCTGAAGTCCTCAACAAACAAGG	PLK2	ENSG00000145632	0.4642044099546736	[787]	[399,838,NaN]	3	hSpCas9	negative selection	10086912
58458081	58458104	5	+	27869803	HPAFII	viability after 31 days	TACCTCCTTCTGTGTTCCAAGGG	PLK2	ENSG00000145632	-0.3179274528178624	[64]	[23,34,NaN]	-2	hSpCas9	negative selection	10086913
58459826	58459849	5	+	27869803	HPAFII	viability after 31 days	GGTGGCTGCGATTCCTCGGGGGG	PLK2	ENSG00000145632	0.5352514521755649	[43]	[30,40,NaN]	4	hSpCas9	negative selection	10086914
58455738	58455761	5	-	28162770	P31FUJ	viability	GGGAAGTGTTGCAGACACAGTGG	PLK2	ENSG00000145632	0.09921470809656764	[227]	[286]	1	hSpCas9	negative selection	10213029
58455702	58455725	5	-	28162770	P31FUJ	viability	GGGATGTCTGGAAAACATGCCGG	PLK2	ENSG00000145632	0.6533298310273425	[111]	[206]	7	hSpCas9	negative selection	10213030
58459858	58459881	5	-	28162770	P31FUJ	viability	GAGCGGACTCGAAGAAGAAGCGG	PLK2	ENSG00000145632	0.3938294756078513	[181]	[280]	4	hSpCas9	negative selection	10213031
58459783	58459806	5	+	28162770	P31FUJ	viability	ATGGTGGTGAGGGGCCGCCGGGG	PLK2	ENSG00000145632	1.221903910355436	[138]	[380]	9	hSpCas9	negative selection	10213032
58458132	58458155	5	-	28162770	P31FUJ	viability	GAAGCCATGGAACTAAAAGTTGG	PLK2	ENSG00000145632	0.7035145051273577	[219]	[420]	7	hSpCas9	negative selection	10213033
58455576	58455599	5	+	28162770	P31FUJ	viability	TGAAAAGGACACCGACGGTGTGG	PLK2	ENSG00000145632	0.8661868902169885	[175]	[376]	8	hSpCas9	negative selection	10213034
58459893	58459916	5	-	28162770	P31FUJ	viability	CAAAATGTGCGAGCAGGCGCTGG	PLK2	ENSG00000145632	-0.13764497137403853	[131]	[140]	-1	hSpCas9	negative selection	10213035
58459875	58459898	5	-	28162770	P31FUJ	viability	GCTGGGCAAGGGTTGCGGAGCGG	PLK2	ENSG00000145632	0.17862404131208637	[199]	[265]	1	hSpCas9	negative selection	10213036
58459824	58459847	5	+	28162770	P31FUJ	viability	GAGGTGGCTGCGATTCCTCGGGG	PLK2	ENSG00000145632	0.257695612303285	[283]	[398]	2	hSpCas9	negative selection	10213037
58459711	58459734	5	+	28162770	P31FUJ	viability	GCAGTAGCGCTTCCCAGTCGTGG	PLK2	ENSG00000145632	-0.09912376918240935	[205]	[225]	-1	hSpCas9	negative selection	10213038
58455738	58455761	5	-	28162770	TF1	viability	GGGAAGTGTTGCAGACACAGTGG	PLK2	ENSG00000145632	NaN	[NaN]	[108]	1	hSpCas9	negative selection	10382395
58455702	58455725	5	-	28162770	TF1	viability	GGGATGTCTGGAAAACATGCCGG	PLK2	ENSG00000145632	NaN	[NaN]	[2]	1	hSpCas9	negative selection	10382396
58459858	58459881	5	-	28162770	TF1	viability	GAGCGGACTCGAAGAAGAAGCGG	PLK2	ENSG00000145632	NaN	[NaN]	[90]	1	hSpCas9	negative selection	10382397
58459783	58459806	5	+	28162770	TF1	viability	ATGGTGGTGAGGGGCCGCCGGGG	PLK2	ENSG00000145632	NaN	[NaN]	[192]	1	hSpCas9	negative selection	10382398
58458132	58458155	5	-	28162770	TF1	viability	GAAGCCATGGAACTAAAAGTTGG	PLK2	ENSG00000145632	NaN	[NaN]	[150]	1	hSpCas9	negative selection	10382399
58455576	58455599	5	+	28162770	TF1	viability	TGAAAAGGACACCGACGGTGTGG	PLK2	ENSG00000145632	NaN	[NaN]	[145]	1	hSpCas9	negative selection	10382400
58459893	58459916	5	-	28162770	TF1	viability	CAAAATGTGCGAGCAGGCGCTGG	PLK2	ENSG00000145632	NaN	[NaN]	[116]	1	hSpCas9	negative selection	10382401
58459875	58459898	5	-	28162770	TF1	viability	GCTGGGCAAGGGTTGCGGAGCGG	PLK2	ENSG00000145632	NaN	[NaN]	[312]	1	hSpCas9	negative selection	10382402
58459824	58459847	5	+	28162770	TF1	viability	GAGGTGGCTGCGATTCCTCGGGG	PLK2	ENSG00000145632	NaN	[NaN]	[194]	1	hSpCas9	negative selection	10382403
58459711	58459734	5	+	28162770	TF1	viability	GCAGTAGCGCTTCCCAGTCGTGG	PLK2	ENSG00000145632	NaN	[NaN]	[164]	1	hSpCas9	negative selection	10382404
58455738	58455761	5	-	28162770	SKM1	viability	GGGAAGTGTTGCAGACACAGTGG	PLK2	ENSG00000145632	0.0021484665785767715	[60]	[107]	0	hSpCas9	negative selection	10551761
58455702	58455725	5	-	28162770	SKM1	viability	GGGATGTCTGGAAAACATGCCGG	PLK2	ENSG00000145632	0.7398771895861096	[20]	[61]	7	hSpCas9	negative selection	10551762
58459858	58459881	5	-	28162770	SKM1	viability	GAGCGGACTCGAAGAAGAAGCGG	PLK2	ENSG00000145632	-0.2713090993855952	[70]	[103]	-2	hSpCas9	negative selection	10551763
58459783	58459806	5	+	28162770	SKM1	viability	ATGGTGGTGAGGGGCCGCCGGGG	PLK2	ENSG00000145632	1.590596755805421	[36]	[196]	9	hSpCas9	negative selection	10551764
58458132	58458155	5	-	28162770	SKM1	viability	GAAGCCATGGAACTAAAAGTTGG	PLK2	ENSG00000145632	0.039292031146402354	[59]	[108]	0	hSpCas9	negative selection	10551765
58455576	58455599	5	+	28162770	SKM1	viability	TGAAAAGGACACCGACGGTGTGG	PLK2	ENSG00000145632	0.75368298911114	[51]	[154]	7	hSpCas9	negative selection	10551766
58459893	58459916	5	-	28162770	SKM1	viability	CAAAATGTGCGAGCAGGCGCTGG	PLK2	ENSG00000145632	-0.32896168674188875	[26]	[37]	-3	hSpCas9	negative selection	10551767
58459875	58459898	5	-	28162770	SKM1	viability	GCTGGGCAAGGGTTGCGGAGCGG	PLK2	ENSG00000145632	0.33180363805702984	[39]	[88]	3	hSpCas9	negative selection	10551768
58459824	58459847	5	+	28162770	SKM1	viability	GAGGTGGCTGCGATTCCTCGGGG	PLK2	ENSG00000145632	0.5303000459088757	[46]	[119]	5	hSpCas9	negative selection	10551769
58459711	58459734	5	+	28162770	SKM1	viability	GCAGTAGCGCTTCCCAGTCGTGG	PLK2	ENSG00000145632	0.24703994640764596	[50]	[106]	2	hSpCas9	negative selection	10551770
58455738	58455761	5	-	28162770	SKM1	viability	GGGAAGTGTTGCAGACACAGTGG	PLK2	ENSG00000145632	0.0021484665785767715	[60]	[107]	0	hSpCas9	negative selection	10721127
58455702	58455725	5	-	28162770	SKM1	viability	GGGATGTCTGGAAAACATGCCGG	PLK2	ENSG00000145632	0.7398771895861096	[20]	[61]	7	hSpCas9	negative selection	10721128
58459858	58459881	5	-	28162770	SKM1	viability	GAGCGGACTCGAAGAAGAAGCGG	PLK2	ENSG00000145632	-0.2713090993855952	[70]	[103]	-2	hSpCas9	negative selection	10721129
58459783	58459806	5	+	28162770	SKM1	viability	ATGGTGGTGAGGGGCCGCCGGGG	PLK2	ENSG00000145632	1.590596755805421	[36]	[196]	9	hSpCas9	negative selection	10721130
58458132	58458155	5	-	28162770	SKM1	viability	GAAGCCATGGAACTAAAAGTTGG	PLK2	ENSG00000145632	0.039292031146402354	[59]	[108]	0	hSpCas9	negative selection	10721131
58455576	58455599	5	+	28162770	SKM1	viability	TGAAAAGGACACCGACGGTGTGG	PLK2	ENSG00000145632	0.75368298911114	[51]	[154]	7	hSpCas9	negative selection	10721132
58459893	58459916	5	-	28162770	SKM1	viability	CAAAATGTGCGAGCAGGCGCTGG	PLK2	ENSG00000145632	-0.32896168674188875	[26]	[37]	-3	hSpCas9	negative selection	10721133
58459875	58459898	5	-	28162770	SKM1	viability	GCTGGGCAAGGGTTGCGGAGCGG	PLK2	ENSG00000145632	0.33180363805702984	[39]	[88]	3	hSpCas9	negative selection	10721134
58459824	58459847	5	+	28162770	SKM1	viability	GAGGTGGCTGCGATTCCTCGGGG	PLK2	ENSG00000145632	0.5303000459088757	[46]	[119]	5	hSpCas9	negative selection	10721135
58459711	58459734	5	+	28162770	SKM1	viability	GCAGTAGCGCTTCCCAGTCGTGG	PLK2	ENSG00000145632	0.24703994640764596	[50]	[106]	2	hSpCas9	negative selection	10721136
58455738	58455761	5	-	28162770	PL21	viability	GGGAAGTGTTGCAGACACAGTGG	PLK2	ENSG00000145632	0.19347588420830947	[216]	[107]	1	hSpCas9	negative selection	10890493
58455702	58455725	5	-	28162770	PL21	viability	GGGATGTCTGGAAAACATGCCGG	PLK2	ENSG00000145632	-0.9804326311525005	[67]	[14]	-6	hSpCas9	negative selection	10890494
58459858	58459881	5	-	28162770	PL21	viability	GAGCGGACTCGAAGAAGAAGCGG	PLK2	ENSG00000145632	0.20013961448932005	[219]	[109]	1	hSpCas9	negative selection	10890495
58459783	58459806	5	+	28162770	PL21	viability	ATGGTGGTGAGGGGCCGCCGGGG	PLK2	ENSG00000145632	-0.5568836320181394	[168]	[49]	-4	hSpCas9	negative selection	10890496
58458132	58458155	5	-	28162770	PL21	viability	GAAGCCATGGAACTAAAAGTTGG	PLK2	ENSG00000145632	-0.9749470920687711	[279]	[61]	-6	hSpCas9	negative selection	10890497
58455576	58455599	5	+	28162770	PL21	viability	TGAAAAGGACACCGACGGTGTGG	PLK2	ENSG00000145632	-0.1256305466924363	[187]	[74]	-1	hSpCas9	negative selection	10890498
58459893	58459916	5	-	28162770	PL21	viability	CAAAATGTGCGAGCAGGCGCTGG	PLK2	ENSG00000145632	1.6236386925163602	[84]	[113]	9	hSpCas9	negative selection	10890499
58459875	58459898	5	-	28162770	PL21	viability	GCTGGGCAAGGGTTGCGGAGCGG	PLK2	ENSG00000145632	-1.3952395021771742	[138]	[22]	-7	hSpCas9	negative selection	10890500
58459824	58459847	5	+	28162770	PL21	viability	GAGGTGGCTGCGATTCCTCGGGG	PLK2	ENSG00000145632	0.47860406089272	[154]	[93]	4	hSpCas9	negative selection	10890501
58459711	58459734	5	+	28162770	PL21	viability	GCAGTAGCGCTTCCCAGTCGTGG	PLK2	ENSG00000145632	0.7147127873190784	[139]	[99]	6	hSpCas9	negative selection	10890502
58455738	58455761	5	-	28162770	P31FUJ	viability	GGGAAGTGTTGCAGACACAGTGG	PLK2	ENSG00000145632	0.09921470809656764	[227]	[286]	1	hSpCas9	negative selection	11059859
58455702	58455725	5	-	28162770	P31FUJ	viability	GGGATGTCTGGAAAACATGCCGG	PLK2	ENSG00000145632	0.6533298310273425	[111]	[206]	7	hSpCas9	negative selection	11059860
58459858	58459881	5	-	28162770	P31FUJ	viability	GAGCGGACTCGAAGAAGAAGCGG	PLK2	ENSG00000145632	0.3938294756078513	[181]	[280]	4	hSpCas9	negative selection	11059861
58459783	58459806	5	+	28162770	P31FUJ	viability	ATGGTGGTGAGGGGCCGCCGGGG	PLK2	ENSG00000145632	1.221903910355436	[138]	[380]	9	hSpCas9	negative selection	11059862
58458132	58458155	5	-	28162770	P31FUJ	viability	GAAGCCATGGAACTAAAAGTTGG	PLK2	ENSG00000145632	0.7035145051273577	[219]	[420]	7	hSpCas9	negative selection	11059863
58455576	58455599	5	+	28162770	P31FUJ	viability	TGAAAAGGACACCGACGGTGTGG	PLK2	ENSG00000145632	0.8661868902169885	[175]	[376]	8	hSpCas9	negative selection	11059864
58459893	58459916	5	-	28162770	P31FUJ	viability	CAAAATGTGCGAGCAGGCGCTGG	PLK2	ENSG00000145632	-0.13764497137403853	[131]	[140]	-1	hSpCas9	negative selection	11059865
58459875	58459898	5	-	28162770	P31FUJ	viability	GCTGGGCAAGGGTTGCGGAGCGG	PLK2	ENSG00000145632	0.17862404131208637	[199]	[265]	1	hSpCas9	negative selection	11059866
58459824	58459847	5	+	28162770	P31FUJ	viability	GAGGTGGCTGCGATTCCTCGGGG	PLK2	ENSG00000145632	0.257695612303285	[283]	[398]	2	hSpCas9	negative selection	11059867
58459711	58459734	5	+	28162770	P31FUJ	viability	GCAGTAGCGCTTCCCAGTCGTGG	PLK2	ENSG00000145632	-0.09912376918240935	[205]	[225]	-1	hSpCas9	negative selection	11059868
58455738	58455761	5	-	28162770	OCIAML5	viability	GGGAAGTGTTGCAGACACAGTGG	PLK2	ENSG00000145632	0.17541416555811007	[129]	[264]	1	hSpCas9	negative selection	11229225
58455702	58455725	5	-	28162770	OCIAML5	viability	GGGATGTCTGGAAAACATGCCGG	PLK2	ENSG00000145632	0.3984768907866001	[28]	[68]	3	hSpCas9	negative selection	11229226
58459858	58459881	5	-	28162770	OCIAML5	viability	GAGCGGACTCGAAGAAGAAGCGG	PLK2	ENSG00000145632	0.2555133163358176	[154]	[333]	2	hSpCas9	negative selection	11229227
58459783	58459806	5	+	28162770	OCIAML5	viability	ATGGTGGTGAGGGGCCGCCGGGG	PLK2	ENSG00000145632	-0.11130939753541658	[75]	[126]	-1	hSpCas9	negative selection	11229228
58458132	58458155	5	-	28162770	OCIAML5	viability	GAAGCCATGGAACTAAAAGTTGG	PLK2	ENSG00000145632	0.4089792818763432	[120]	[289]	3	hSpCas9	negative selection	11229229
58455576	58455599	5	+	28162770	OCIAML5	viability	TGAAAAGGACACCGACGGTGTGG	PLK2	ENSG00000145632	-0.10332380892143708	[121]	[204]	0	hSpCas9	negative selection	11229230
58459893	58459916	5	-	28162770	OCIAML5	viability	CAAAATGTGCGAGCAGGCGCTGG	PLK2	ENSG00000145632	0.017872888571630052	[86]	[158]	0	hSpCas9	negative selection	11229231
58459875	58459898	5	-	28162770	OCIAML5	viability	GCTGGGCAAGGGTTGCGGAGCGG	PLK2	ENSG00000145632	0.05922920386452275	[108]	[204]	0	hSpCas9	negative selection	11229232
58459824	58459847	5	+	28162770	OCIAML5	viability	GAGGTGGCTGCGATTCCTCGGGG	PLK2	ENSG00000145632	0.4216942415628552	[133]	[323]	3	hSpCas9	negative selection	11229233
58459711	58459734	5	+	28162770	OCIAML5	viability	GCAGTAGCGCTTCCCAGTCGTGG	PLK2	ENSG00000145632	-0.34882846757729447	[114]	[162]	-2	hSpCas9	negative selection	11229234
58455738	58455761	5	-	28162770	EOL1	viability	GGGAAGTGTTGCAGACACAGTGG	PLK2	ENSG00000145632	-0.350312069660049	[391]	[161]	-3	hSpCas9	negative selection	11398591
58455702	58455725	5	-	28162770	EOL1	viability	GGGATGTCTGGAAAACATGCCGG	PLK2	ENSG00000145632	-0.6437359880039917	[85]	[28]	-5	hSpCas9	negative selection	11398592
58459858	58459881	5	-	28162770	EOL1	viability	GAGCGGACTCGAAGAAGAAGCGG	PLK2	ENSG00000145632	0.4292679848886575	[381]	[270]	4	hSpCas9	negative selection	11398593
58459783	58459806	5	+	28162770	EOL1	viability	ATGGTGGTGAGGGGCCGCCGGGG	PLK2	ENSG00000145632	1.2237557899578135	[255]	[314]	8	hSpCas9	negative selection	11398594
58458132	58458155	5	-	28162770	EOL1	viability	GAAGCCATGGAACTAAAAGTTGG	PLK2	ENSG00000145632	-0.40065545534968866	[440]	[175]	-3	hSpCas9	negative selection	11398595
58455576	58455599	5	+	28162770	EOL1	viability	TGAAAAGGACACCGACGGTGTGG	PLK2	ENSG00000145632	0.9379061544255536	[429]	[433]	7	hSpCas9	negative selection	11398596
58459893	58459916	5	-	28162770	EOL1	viability	CAAAATGTGCGAGCAGGCGCTGG	PLK2	ENSG00000145632	0.3976173922207934	[133]	[92]	3	hSpCas9	negative selection	11398597
58459875	58459898	5	-	28162770	EOL1	viability	GCTGGGCAAGGGTTGCGGAGCGG	PLK2	ENSG00000145632	0.8698048069761025	[187]	[180]	7	hSpCas9	negative selection	11398598
58459824	58459847	5	+	28162770	EOL1	viability	GAGGTGGCTGCGATTCCTCGGGG	PLK2	ENSG00000145632	-0.2607314767488139	[306]	[134]	-2	hSpCas9	negative selection	11398599
58459711	58459734	5	+	28162770	EOL1	viability	GCAGTAGCGCTTCCCAGTCGTGG	PLK2	ENSG00000145632	-1.115609354901448	[254]	[61]	-6	hSpCas9	negative selection	11398600
58455738	58455761	5	-	28162770	MOLM13	viability	GGGAAGTGTTGCAGACACAGTGG	PLK2	ENSG00000145632	0.3203321931307211	[287]	[259]	2	hSpCas9	negative selection	11567957
58455702	58455725	5	-	28162770	MOLM13	viability	GGGATGTCTGGAAAACATGCCGG	PLK2	ENSG00000145632	-1.2545766429265124	[131]	[39]	-6	hSpCas9	negative selection	11567958
58459858	58459881	5	-	28162770	MOLM13	viability	GAGCGGACTCGAAGAAGAAGCGG	PLK2	ENSG00000145632	0.24549696020813094	[370]	[317]	1	hSpCas9	negative selection	11567959
58459783	58459806	5	+	28162770	MOLM13	viability	ATGGTGGTGAGGGGCCGCCGGGG	PLK2	ENSG00000145632	1.3047241818122286	[172]	[308]	8	hSpCas9	negative selection	11567960
58458132	58458155	5	-	28162770	MOLM13	viability	GAAGCCATGGAACTAAAAGTTGG	PLK2	ENSG00000145632	0.5703049481577422	[366]	[393]	4	hSpCas9	negative selection	11567961
58455576	58455599	5	+	28162770	MOLM13	viability	TGAAAAGGACACCGACGGTGTGG	PLK2	ENSG00000145632	-0.872601164369211	[351]	[138]	-5	hSpCas9	negative selection	11567962
58459893	58459916	5	-	28162770	MOLM13	viability	CAAAATGTGCGAGCAGGCGCTGG	PLK2	ENSG00000145632	0.4149405015956198	[110]	[106]	3	hSpCas9	negative selection	11567963
58459875	58459898	5	-	28162770	MOLM13	viability	GCTGGGCAAGGGTTGCGGAGCGG	PLK2	ENSG00000145632	0.8158126849648857	[197]	[251]	6	hSpCas9	negative selection	11567964
58459824	58459847	5	+	28162770	MOLM13	viability	GAGGTGGCTGCGATTCCTCGGGG	PLK2	ENSG00000145632	0.18679500416579403	[208]	[171]	1	hSpCas9	negative selection	11567965
58459711	58459734	5	+	28162770	MOLM13	viability	GCAGTAGCGCTTCCCAGTCGTGG	PLK2	ENSG00000145632	-0.2426040012604364	[215]	[131]	-1	hSpCas9	negative selection	11567966
58455738	58455761	5	-	28162770	HEL	viability	GGGAAGTGTTGCAGACACAGTGG	PLK2	ENSG00000145632	0.5861553036339895	[233]	[224]	5	hSpCas9	negative selection	11737323
58455702	58455725	5	-	28162770	HEL	viability	GGGATGTCTGGAAAACATGCCGG	PLK2	ENSG00000145632	0.7148886177561924	[116]	[122]	6	hSpCas9	negative selection	11737324
58459858	58459881	5	-	28162770	HEL	viability	GAGCGGACTCGAAGAAGAAGCGG	PLK2	ENSG00000145632	0.550226693210819	[321]	[301]	4	hSpCas9	negative selection	11737325
58459783	58459806	5	+	28162770	HEL	viability	ATGGTGGTGAGGGGCCGCCGGGG	PLK2	ENSG00000145632	1.1978420440284028	[178]	[262]	9	hSpCas9	negative selection	11737326
58458132	58458155	5	-	28162770	HEL	viability	GAAGCCATGGAACTAAAAGTTGG	PLK2	ENSG00000145632	0.5552759907500178	[288]	[271]	5	hSpCas9	negative selection	11737327
58455576	58455599	5	+	28162770	HEL	viability	TGAAAAGGACACCGACGGTGTGG	PLK2	ENSG00000145632	0.2115323958280017	[328]	[243]	1	hSpCas9	negative selection	11737328
58459893	58459916	5	-	28162770	HEL	viability	CAAAATGTGCGAGCAGGCGCTGG	PLK2	ENSG00000145632	0.29791033500291564	[126]	[99]	2	hSpCas9	negative selection	11737329
58459875	58459898	5	-	28162770	HEL	viability	GCTGGGCAAGGGTTGCGGAGCGG	PLK2	ENSG00000145632	1.3061426873241593	[172]	[273]	9	hSpCas9	negative selection	11737330
58459824	58459847	5	+	28162770	HEL	viability	GAGGTGGCTGCGATTCCTCGGGG	PLK2	ENSG00000145632	0.6593217161959614	[172]	[174]	5	hSpCas9	negative selection	11737331
58459711	58459734	5	+	28162770	HEL	viability	GCAGTAGCGCTTCCCAGTCGTGG	PLK2	ENSG00000145632	-1.1079016990629258	[211]	[62]	-6	hSpCas9	negative selection	11737332
58455738	58455761	5	-	28162770	MV411	viability	GGGAAGTGTTGCAGACACAGTGG	PLK2	ENSG00000145632	-1.3162301715751528	[268]	[90]	-7	hSpCas9	negative selection	11906689
58455702	58455725	5	-	28162770	MV411	viability	GGGATGTCTGGAAAACATGCCGG	PLK2	ENSG00000145632	0.26605322895012196	[76]	[77]	2	hSpCas9	negative selection	11906690
58459858	58459881	5	-	28162770	MV411	viability	GAGCGGACTCGAAGAAGAAGCGG	PLK2	ENSG00000145632	-0.11795857268069651	[218]	[169]	-1	hSpCas9	negative selection	11906691
58459783	58459806	5	+	28162770	MV411	viability	ATGGTGGTGAGGGGCCGCCGGGG	PLK2	ENSG00000145632	0.4624504417536258	[167]	[194]	4	hSpCas9	negative selection	11906692
58458132	58458155	5	-	28162770	MV411	viability	GAAGCCATGGAACTAAAAGTTGG	PLK2	ENSG00000145632	0.32989971097474824	[203]	[215]	3	hSpCas9	negative selection	11906693
58455576	58455599	5	+	28162770	MV411	viability	TGAAAAGGACACCGACGGTGTGG	PLK2	ENSG00000145632	0.588025100901738	[168]	[213]	5	hSpCas9	negative selection	11906694
58459893	58459916	5	-	28162770	MV411	viability	CAAAATGTGCGAGCAGGCGCTGG	PLK2	ENSG00000145632	0.6590684486183696	[105]	[140]	6	hSpCas9	negative selection	11906695
58459875	58459898	5	-	28162770	MV411	viability	GCTGGGCAAGGGTTGCGGAGCGG	PLK2	ENSG00000145632	0.5970219885730029	[185]	[236]	5	hSpCas9	negative selection	11906696
58459824	58459847	5	+	28162770	MV411	viability	GAGGTGGCTGCGATTCCTCGGGG	PLK2	ENSG00000145632	0.02116169495909931	[185]	[158]	0	hSpCas9	negative selection	11906697
58459711	58459734	5	+	28162770	MV411	viability	GCAGTAGCGCTTCCCAGTCGTGG	PLK2	ENSG00000145632	-0.4750284736883157	[197]	[119]	-4	hSpCas9	negative selection	11906698
58455738	58455761	5	-	28162770	MONOMAC1	viability	GGGAAGTGTTGCAGACACAGTGG	PLK2	ENSG00000145632	0.07089635818707934	[146]	[176]	0	hSpCas9	negative selection	12076055
58455702	58455725	5	-	28162770	MONOMAC1	viability	GGGATGTCTGGAAAACATGCCGG	PLK2	ENSG00000145632	0.15088645636075326	[43]	[55]	1	hSpCas9	negative selection	12076056
58459858	58459881	5	-	28162770	MONOMAC1	viability	GAGCGGACTCGAAGAAGAAGCGG	PLK2	ENSG00000145632	0.42165651097415213	[154]	[237]	4	hSpCas9	negative selection	12076057
58459783	58459806	5	+	28162770	MONOMAC1	viability	ATGGTGGTGAGGGGCCGCCGGGG	PLK2	ENSG00000145632	-0.17713728962184883	[71]	[72]	-1	hSpCas9	negative selection	12076058
58458132	58458155	5	-	28162770	MONOMAC1	viability	GAAGCCATGGAACTAAAAGTTGG	PLK2	ENSG00000145632	0.4214003582126906	[141]	[217]	4	hSpCas9	negative selection	12076059
58455576	58455599	5	+	28162770	MONOMAC1	viability	TGAAAAGGACACCGACGGTGTGG	PLK2	ENSG00000145632	0.8991784681997494	[86]	[185]	8	hSpCas9	negative selection	12076060
58459893	58459916	5	-	28162770	MONOMAC1	viability	CAAAATGTGCGAGCAGGCGCTGG	PLK2	ENSG00000145632	-0.19703684705955382	[47]	[47]	-2	hSpCas9	negative selection	12076061
58459875	58459898	5	-	28162770	MONOMAC1	viability	GCTGGGCAAGGGTTGCGGAGCGG	PLK2	ENSG00000145632	0.6582280599594355	[109]	[198]	6	hSpCas9	negative selection	12076062
58459824	58459847	5	+	28162770	MONOMAC1	viability	GAGGTGGCTGCGATTCCTCGGGG	PLK2	ENSG00000145632	0.8601070600440551	[98]	[205]	7	hSpCas9	negative selection	12076063
58459711	58459734	5	+	28162770	MONOMAC1	viability	GCAGTAGCGCTTCCCAGTCGTGG	PLK2	ENSG00000145632	-0.4898185962873994	[97]	[79]	-4	hSpCas9	negative selection	12076064
58455738	58455761	5	-	28162770	OCIAML2	viability	GGGAAGTGTTGCAGACACAGTGG	PLK2	ENSG00000145632	0.10427901081507207	[47]	[285]	1	hSpCas9	negative selection	12245421
58455702	58455725	5	-	28162770	OCIAML2	viability	GGGATGTCTGGAAAACATGCCGG	PLK2	ENSG00000145632	-1.6741632193272928	[18]	[32]	-7	hSpCas9	negative selection	12245422
58459858	58459881	5	-	28162770	OCIAML2	viability	GAGCGGACTCGAAGAAGAAGCGG	PLK2	ENSG00000145632	-0.011198206604863925	[49]	[274]	0	hSpCas9	negative selection	12245423
58459783	58459806	5	+	28162770	OCIAML2	viability	ATGGTGGTGAGGGGCCGCCGGGG	PLK2	ENSG00000145632	-0.14870173035479875	[30]	[154]	-1	hSpCas9	negative selection	12245424
58458132	58458155	5	-	28162770	OCIAML2	viability	GAAGCCATGGAACTAAAAGTTGG	PLK2	ENSG00000145632	1.0283301575817736	[35]	[406]	8	hSpCas9	negative selection	12245425
58455576	58455599	5	+	28162770	OCIAML2	viability	TGAAAAGGACACCGACGGTGTGG	PLK2	ENSG00000145632	0.6402159434461291	[35]	[310]	6	hSpCas9	negative selection	12245426
58459893	58459916	5	-	28162770	OCIAML2	viability	CAAAATGTGCGAGCAGGCGCTGG	PLK2	ENSG00000145632	0.8294938993268527	[19]	[196]	7	hSpCas9	negative selection	12245427
58459875	58459898	5	-	28162770	OCIAML2	viability	GCTGGGCAAGGGTTGCGGAGCGG	PLK2	ENSG00000145632	0.8259871811160138	[22]	[225]	7	hSpCas9	negative selection	12245428
58459824	58459847	5	+	28162770	OCIAML2	viability	GAGGTGGCTGCGATTCCTCGGGG	PLK2	ENSG00000145632	1.0147970019280805	[24]	[279]	8	hSpCas9	negative selection	12245429
58459711	58459734	5	+	28162770	OCIAML2	viability	GCAGTAGCGCTTCCCAGTCGTGG	PLK2	ENSG00000145632	-0.5010034742856799	[23]	[93]	-4	hSpCas9	negative selection	12245430
58455738	58455761	5	-	28162770	OCIAML3	viability	GGGAAGTGTTGCAGACACAGTGG	PLK2	ENSG00000145632	0.04107833982282949	[65]	[204]	0	hSpCas9	negative selection	12414787
58455702	58455725	5	-	28162770	OCIAML3	viability	GGGATGTCTGGAAAACATGCCGG	PLK2	ENSG00000145632	0.9262491710091778	[18]	[108]	7	hSpCas9	negative selection	12414788
58459858	58459881	5	-	28162770	OCIAML3	viability	GAGCGGACTCGAAGAAGAAGCGG	PLK2	ENSG00000145632	0.6525386427210618	[54]	[260]	6	hSpCas9	negative selection	12414789
58459783	58459806	5	+	28162770	OCIAML3	viability	ATGGTGGTGAGGGGCCGCCGGGG	PLK2	ENSG00000145632	0.5178852397467342	[30]	[133]	5	hSpCas9	negative selection	12414790
58458132	58458155	5	-	28162770	OCIAML3	viability	GAAGCCATGGAACTAAAAGTTGG	PLK2	ENSG00000145632	0.8757956623855726	[62]	[348]	7	hSpCas9	negative selection	12414791
58455576	58455599	5	+	28162770	OCIAML3	viability	TGAAAAGGACACCGACGGTGTGG	PLK2	ENSG00000145632	-0.29254364799651633	[70]	[174]	-2	hSpCas9	negative selection	12414792
58459893	58459916	5	-	28162770	OCIAML3	viability	CAAAATGTGCGAGCAGGCGCTGG	PLK2	ENSG00000145632	-0.31389972113142794	[27]	[67]	-2	hSpCas9	negative selection	12414793
58459875	58459898	5	-	28162770	OCIAML3	viability	GCTGGGCAAGGGTTGCGGAGCGG	PLK2	ENSG00000145632	0.24424128967922482	[32]	[117]	2	hSpCas9	negative selection	12414794
58459824	58459847	5	+	28162770	OCIAML3	viability	GAGGTGGCTGCGATTCCTCGGGG	PLK2	ENSG00000145632	0.8112488381620955	[36]	[195]	7	hSpCas9	negative selection	12414795
58459711	58459734	5	+	28162770	OCIAML3	viability	GCAGTAGCGCTTCCCAGTCGTGG	PLK2	ENSG00000145632	0.04511063044389843	[60]	[189]	0	hSpCas9	negative selection	12414796