127886421 | 127886444 | 4 | + | 26472758 | Jiyoye | viability | GAAACCAGTAATAGTGGAAGGGG | PLK4 | ENSG00000142731 | -0.4922977425401623 | [96] | [51] | -4 | hSpCas9 | negative selection | 122460 | 127893777 | 127893800 | 4 | - | 26472758 | Jiyoye | viability | GGGTAATTTGAATCCACAGAAGG | PLK4 | ENSG00000142731 | 0.47756470939727125 | [19] | [20] | 3 | hSpCas9 | negative selection | 122461 | 127886605 | 127886628 | 4 | + | 26472758 | Jiyoye | viability | GAGGAGGTGAAAATGAAGAGAGG | PLK4 | ENSG00000142731 | -2.9949230620654723 | [147] | [13] | -9 | hSpCas9 | negative selection | 122462 | 127887452 | 127887475 | 4 | + | 26472758 | Jiyoye | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.8499824579912512 | [97] | [40] | -5 | hSpCas9 | negative selection | 122463 | 127890138 | 127890161 | 4 | - | 26472758 | Jiyoye | viability | CGATTCTGATAACCCCATGGTGG | PLK4 | ENSG00000142731 | -1.964080425745057 | [237] | [45] | -8 | hSpCas9 | negative selection | 122464 | 127891094 | 127891117 | 4 | + | 26472758 | Jiyoye | viability | GAGCATACTTGATTCAGAGGAGG | PLK4 | ENSG00000142731 | -1.914752713381489 | [154] | [30] | -8 | hSpCas9 | negative selection | 122465 | 127885995 | 127886018 | 4 | - | 26472758 | Jiyoye | viability | ACTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -1.1777871192152827 | [83] | [27] | -7 | hSpCas9 | negative selection | 122466 | 127886118 | 127886141 | 4 | - | 26472758 | Jiyoye | viability | GACAGACTTAAACGATCTGCTGG | PLK4 | ENSG00000142731 | 2.5140905854223856 | [12] | [55] | 9 | hSpCas9 | negative selection | 122467 | 127886486 | 127886509 | 4 | - | 26472758 | Jiyoye | viability | CAGAGGAATAAGCTCTACGAAGG | PLK4 | ENSG00000142731 | -5.265249960465622 | [50] | [0] | -9 | hSpCas9 | negative selection | 122468 | 127886586 | 127886609 | 4 | + | 26472758 | Jiyoye | viability | TCAGTGTCCAAAAGATCAGGAGG | PLK4 | ENSG00000142731 | -1.6992139630861036 | [210] | [48] | -8 | hSpCas9 | negative selection | 122469 | 127886421 | 127886444 | 4 | + | 26472758 | KBM7 | viability | GAAACCAGTAATAGTGGAAGGGG | PLK4 | ENSG00000142731 | -1.2459614140528332 | [592,426] | [110,89] | -7 | hSpCas9 | negative selection | 313578 | 127893777 | 127893800 | 4 | - | 26472758 | KBM7 | viability | GGGTAATTTGAATCCACAGAAGG | PLK4 | ENSG00000142731 | -0.7943313766005687 | [300,242] | [95,52] | -6 | hSpCas9 | negative selection | 313579 | 127886605 | 127886628 | 4 | + | 26472758 | KBM7 | viability | GAGGAGGTGAAAATGAAGAGAGG | PLK4 | ENSG00000142731 | -2.5056016045008045 | [387,236] | [27,22] | -9 | hSpCas9 | negative selection | 313580 | 127887452 | 127887475 | 4 | + | 26472758 | KBM7 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | 0.3893206224730924 | [218,240] | [151,134] | 4 | hSpCas9 | negative selection | 313581 | 127890138 | 127890161 | 4 | - | 26472758 | KBM7 | viability | CGATTCTGATAACCCCATGGTGG | PLK4 | ENSG00000142731 | -1.3911169616277306 | [644,583] | [116,103] | -7 | hSpCas9 | negative selection | 313582 | 127891094 | 127891117 | 4 | + | 26472758 | KBM7 | viability | GAGCATACTTGATTCAGAGGAGG | PLK4 | ENSG00000142731 | -2.5281903442115654 | [991,766] | [106,38] | -9 | hSpCas9 | negative selection | 313583 | 127885995 | 127886018 | 4 | - | 26472758 | KBM7 | viability | ACTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -1.5345198890998524 | [279,199] | [19,54] | -8 | hSpCas9 | negative selection | 313584 | 127886118 | 127886141 | 4 | - | 26472758 | KBM7 | viability | GACAGACTTAAACGATCTGCTGG | PLK4 | ENSG00000142731 | -0.011536975694631857 | [237,251] | [111,117] | 0 | hSpCas9 | negative selection | 313585 | 127886486 | 127886509 | 4 | - | 26472758 | KBM7 | viability | CAGAGGAATAAGCTCTACGAAGG | PLK4 | ENSG00000142731 | -3.448537737172655 | [99,48] | [0,4] | -9 | hSpCas9 | negative selection | 313586 | 127886586 | 127886609 | 4 | + | 26472758 | KBM7 | viability | TCAGTGTCCAAAAGATCAGGAGG | PLK4 | ENSG00000142731 | -0.5786114576948782 | [1306,1140] | [354,410] | -5 | hSpCas9 | negative selection | 313587 | 127886421 | 127886444 | 4 | + | 26472758 | Raji | viability | GAAACCAGTAATAGTGGAAGGGG | PLK4 | ENSG00000142731 | 0.09597877210135015 | [253] | [62] | 0 | hSpCas9 | negative selection | 504696 | 127893777 | 127893800 | 4 | - | 26472758 | Raji | viability | GGGTAATTTGAATCCACAGAAGG | PLK4 | ENSG00000142731 | -1.6328571908254674 | [146] | [10] | -8 | hSpCas9 | negative selection | 504697 | 127886605 | 127886628 | 4 | + | 26472758 | Raji | viability | GAGGAGGTGAAAATGAAGAGAGG | PLK4 | ENSG00000142731 | -2.3374013072992965 | [195] | [8] | -9 | hSpCas9 | negative selection | 504698 | 127887452 | 127887475 | 4 | + | 26472758 | Raji | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | 0.1687840800377428 | [137] | [35] | 1 | hSpCas9 | negative selection | 504699 | 127890138 | 127890161 | 4 | - | 26472758 | Raji | viability | CGATTCTGATAACCCCATGGTGG | PLK4 | ENSG00000142731 | 0.9598959230510424 | [318] | [143] | 8 | hSpCas9 | negative selection | 504700 | 127891094 | 127891117 | 4 | + | 26472758 | Raji | viability | GAGCATACTTGATTCAGAGGAGG | PLK4 | ENSG00000142731 | -1.3484003062485534 | [394] | [35] | -7 | hSpCas9 | negative selection | 504701 | 127885995 | 127886018 | 4 | - | 26472758 | Raji | viability | ACTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -2.373743154363017 | [66] | [2] | -9 | hSpCas9 | negative selection | 504702 | 127886118 | 127886141 | 4 | - | 26472758 | Raji | viability | GACAGACTTAAACGATCTGCTGG | PLK4 | ENSG00000142731 | -0.6150824890974915 | [131] | [19] | -5 | hSpCas9 | negative selection | 504703 | 127886486 | 127886509 | 4 | - | 26472758 | Raji | viability | CAGAGGAATAAGCTCTACGAAGG | PLK4 | ENSG00000142731 | -1.6150824890974915 | [65] | [4] | -8 | hSpCas9 | negative selection | 504704 | 127886586 | 127886609 | 4 | + | 26472758 | Raji | viability | TCAGTGTCCAAAAGATCAGGAGG | PLK4 | ENSG00000142731 | -0.1336245641301954 | [467] | [98] | -1 | hSpCas9 | negative selection | 504705 | 127886421 | 127886444 | 4 | + | 26472758 | K562 | viability | GAAACCAGTAATAGTGGAAGGGG | PLK4 | ENSG00000142731 | -0.19983069282888444 | [448] | [329] | -1 | hSpCas9 | negative selection | 695814 | 127893777 | 127893800 | 4 | - | 26472758 | K562 | viability | GGGTAATTTGAATCCACAGAAGG | PLK4 | ENSG00000142731 | -0.31978521288791184 | [206] | [139] | -2 | hSpCas9 | negative selection | 695815 | 127886605 | 127886628 | 4 | + | 26472758 | K562 | viability | GAGGAGGTGAAAATGAAGAGAGG | PLK4 | ENSG00000142731 | -0.8180453592802066 | [235] | [112] | -5 | hSpCas9 | negative selection | 695816 | 127887452 | 127887475 | 4 | + | 26472758 | K562 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | 0.5560048783323503 | [223] | [277] | 4 | hSpCas9 | negative selection | 695817 | 127890138 | 127890161 | 4 | - | 26472758 | K562 | viability | CGATTCTGATAACCCCATGGTGG | PLK4 | ENSG00000142731 | 0.7753702937374939 | [507] | [733] | 6 | hSpCas9 | negative selection | 695818 | 127891094 | 127891117 | 4 | + | 26472758 | K562 | viability | GAGCATACTTGATTCAGAGGAGG | PLK4 | ENSG00000142731 | -2.2109717257489865 | [712] | [129] | -7 | hSpCas9 | negative selection | 695819 | 127885995 | 127886018 | 4 | - | 26472758 | K562 | viability | ACTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -0.9324590344176322 | [103] | [45] | -5 | hSpCas9 | negative selection | 695820 | 127886118 | 127886141 | 4 | - | 26472758 | K562 | viability | GACAGACTTAAACGATCTGCTGG | PLK4 | ENSG00000142731 | 0.38015676674871274 | [222] | [244] | 3 | hSpCas9 | negative selection | 695821 | 127886486 | 127886509 | 4 | - | 26472758 | K562 | viability | CAGAGGAATAAGCTCTACGAAGG | PLK4 | ENSG00000142731 | -3.5629361943911575 | [55] | [3] | -8 | hSpCas9 | negative selection | 695822 | 127886586 | 127886609 | 4 | + | 26472758 | K562 | viability | TCAGTGTCCAAAAGATCAGGAGG | PLK4 | ENSG00000142731 | -0.28318791499609364 | [825] | [572] | -2 | hSpCas9 | negative selection | 695823 | 127885914 | 127885937 | 4 | + | 26627737 | DLD1 | viability | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | -1.3113456691536378 | [325] | [27,84,15] | -8 | hSpCas9 | negative selection | 823812 | 127885998 | 127886021 | 4 | - | 26627737 | DLD1 | viability | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | -0.7433559528111575 | [1216] | [290,190,201] | -6 | hSpCas9 | negative selection | 823813 | 127887430 | 127887453 | 4 | - | 26627737 | DLD1 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -1.1392089525381093 | [1153] | [137,146,199] | -7 | hSpCas9 | negative selection | 823814 | 127891615 | 127891638 | 4 | - | 26627737 | DLD1 | viability | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -2.8698003720467606 | [367] | [42,4,0] | -9 | hSpCas9 | negative selection | 823815 | 127893839 | 127893862 | 4 | + | 26627737 | DLD1 | viability | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | -0.696821186042125 | [594] | [105,125,112] | -6 | hSpCas9 | negative selection | 823816 | 127895072 | 127895095 | 4 | + | 26627737 | DLD1 | viability | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | -0.3846621597077822 | [468] | [95,113,124] | -4 | hSpCas9 | negative selection | 823817 | 127885914 | 127885937 | 4 | + | 26627737 | GBM cells | viability after 5 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | 0.2668893372924843 | [147] | [129,60] | 4 | hSpCas9 | negative selection | 906127 | 127885998 | 127886021 | 4 | - | 26627737 | GBM cells | viability after 5 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | 0.1443121397907734 | [630] | [373,373] | 2 | hSpCas9 | negative selection | 906128 | 127887430 | 127887453 | 4 | - | 26627737 | GBM cells | viability after 5 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.06911763104645541 | [574] | [303,342] | 1 | hSpCas9 | negative selection | 906129 | 127891615 | 127891638 | 4 | - | 26627737 | GBM cells | viability after 5 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -0.15857161977507472 | [127] | [75,46] | -2 | hSpCas9 | negative selection | 906130 | 127893839 | 127893862 | 4 | + | 26627737 | GBM cells | viability after 5 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | -0.676734874695841 | [385] | [101,156] | -8 | hSpCas9 | negative selection | 906131 | 127895072 | 127895095 | 4 | + | 26627737 | GBM cells | viability after 5 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | -0.1531328728839097 | [253] | [114,129] | -2 | hSpCas9 | negative selection | 906132 | 127885914 | 127885937 | 4 | + | 26627737 | GBM cells | viability after 13 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | 0.06988395977782558 | [147] | [107,64] | 0 | hSpCas9 | negative selection | 988442 | 127885998 | 127886021 | 4 | - | 26627737 | GBM cells | viability after 13 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | 0.21381587417111447 | [630] | [449,353] | 2 | hSpCas9 | negative selection | 988443 | 127887430 | 127887453 | 4 | - | 26627737 | GBM cells | viability after 13 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.3929226241474715 | [574] | [466,362] | 5 | hSpCas9 | negative selection | 988444 | 127891615 | 127891638 | 4 | - | 26627737 | GBM cells | viability after 13 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -0.7314003519771309 | [127] | [48,35] | -7 | hSpCas9 | negative selection | 988445 | 127893839 | 127893862 | 4 | + | 26627737 | GBM cells | viability after 13 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | -1.226301104462157 | [385] | [83,93] | -8 | hSpCas9 | negative selection | 988446 | 127895072 | 127895095 | 4 | + | 26627737 | GBM cells | viability after 13 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | -0.22375872754703 | [253] | [149,91] | -3 | hSpCas9 | negative selection | 988447 | 127885914 | 127885937 | 4 | + | 26627737 | GBM cells | viability after 21 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | -0.943022249614429 | [147] | [45,37] | -7 | hSpCas9 | negative selection | 1070757 | 127885998 | 127886021 | 4 | - | 26627737 | GBM cells | viability after 21 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | 0.1584720648826068 | [630] | [426,341] | 1 | hSpCas9 | negative selection | 1070758 | 127887430 | 127887453 | 4 | - | 26627737 | GBM cells | viability after 21 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.5525788312993167 | [574] | [453,461] | 5 | hSpCas9 | negative selection | 1070759 | 127891615 | 127891638 | 4 | - | 26627737 | GBM cells | viability after 21 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -0.34424786544874253 | [127] | [59,49] | -3 | hSpCas9 | negative selection | 1070760 | 127893839 | 127893862 | 4 | + | 26627737 | GBM cells | viability after 21 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | -0.7872793063760366 | [385] | [132,110] | -6 | hSpCas9 | negative selection | 1070761 | 127895072 | 127895095 | 4 | + | 26627737 | GBM cells | viability after 21 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | -0.04811572392903252 | [253] | [145,121] | 0 | hSpCas9 | negative selection | 1070762 | 127885914 | 127885937 | 4 | + | 26627737 | RPE1 | viability after 9 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | 0.1298798270754351 | [86] | [24,35] | 0 | hSpCas9 | negative selection | 1153072 | 127885998 | 127886021 | 4 | - | 26627737 | RPE1 | viability after 9 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | -0.7982458883439811 | [2202] | [262,568] | -5 | hSpCas9 | negative selection | 1153073 | 127887430 | 127887453 | 4 | - | 26627737 | RPE1 | viability after 9 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -1.4317099086907592 | [2740] | [366,254] | -8 | hSpCas9 | negative selection | 1153074 | 127891615 | 127891638 | 4 | - | 26627737 | RPE1 | viability after 9 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -1.1578894992700657 | [130] | [20,14] | -7 | hSpCas9 | negative selection | 1153075 | 127893839 | 127893862 | 4 | + | 26627737 | RPE1 | viability after 9 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | -1.4991221883352335 | [1831] | [91,345] | -8 | hSpCas9 | negative selection | 1153076 | 127895072 | 127895095 | 4 | + | 26627737 | RPE1 | viability after 9 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | 0.6731029583231888 | [268] | [87,193] | 4 | hSpCas9 | negative selection | 1153077 | 127885914 | 127885937 | 4 | + | 26627737 | RPE1 | viability after 12 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | -0.44010090922047196 | [86] | [24,8] | -3 | hSpCas9 | negative selection | 1235387 | 127885998 | 127886021 | 4 | - | 26627737 | RPE1 | viability after 12 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | -1.2721679796204572 | [2202] | [246,242] | -7 | hSpCas9 | negative selection | 1235388 | 127887430 | 127887453 | 4 | - | 26627737 | RPE1 | viability after 12 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -1.5902631368090945 | [2740] | [297,187] | -8 | hSpCas9 | negative selection | 1235389 | 127891615 | 127891638 | 4 | - | 26627737 | RPE1 | viability after 12 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -1.531884986583441 | [130] | [0,23] | -8 | hSpCas9 | negative selection | 1235390 | 127893839 | 127893862 | 4 | + | 26627737 | RPE1 | viability after 12 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | -1.374321909205236 | [1831] | [82,302] | -7 | hSpCas9 | negative selection | 1235391 | 127895072 | 127895095 | 4 | + | 26627737 | RPE1 | viability after 12 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | 0.4104700414077145 | [268] | [114,75] | 2 | hSpCas9 | negative selection | 1235392 | 127885914 | 127885937 | 4 | + | 26627737 | RPE1 | viability after 15 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | -1.5985255466271178 | [86] | [0,14] | -7 | hSpCas9 | negative selection | 1317702 | 127885998 | 127886021 | 4 | - | 26627737 | RPE1 | viability after 15 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | -1.8190376972943927 | [2202] | [141,209] | -8 | hSpCas9 | negative selection | 1317703 | 127887430 | 127887453 | 4 | - | 26627737 | RPE1 | viability after 15 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -2.0543589379086953 | [2740] | [204,168] | -8 | hSpCas9 | negative selection | 1317704 | 127891615 | 127891638 | 4 | - | 26627737 | RPE1 | viability after 15 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -2.101353215841429 | [130] | [0,15] | -8 | hSpCas9 | negative selection | 1317705 | 127893839 | 127893862 | 4 | + | 26627737 | RPE1 | viability after 15 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | -0.7910100271563445 | [1831] | [270,326] | -5 | hSpCas9 | negative selection | 1317706 | 127895072 | 127895095 | 4 | + | 26627737 | RPE1 | viability after 15 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | -0.5163223363308174 | [268] | [69,36] | -3 | hSpCas9 | negative selection | 1317707 | 127885914 | 127885937 | 4 | + | 26627737 | RPE1 | viability after 18 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | -0.897706362597503 | [86] | [0,24] | -5 | hSpCas9 | negative selection | 1400017 | 127885998 | 127886021 | 4 | - | 26627737 | RPE1 | viability after 18 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | -2.1690174970672054 | [2202] | [137,125] | -8 | hSpCas9 | negative selection | 1400018 | 127887430 | 127887453 | 4 | - | 26627737 | RPE1 | viability after 18 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -1.8346253924800255 | [2740] | [174,241] | -8 | hSpCas9 | negative selection | 1400019 | 127891615 | 127891638 | 4 | - | 26627737 | RPE1 | viability after 18 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -1.79540416271611 | [130] | [0,19] | -8 | hSpCas9 | negative selection | 1400020 | 127893839 | 127893862 | 4 | + | 26627737 | RPE1 | viability after 18 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | -1.1682690549925445 | [1831] | [102,344] | -6 | hSpCas9 | negative selection | 1400021 | 127895072 | 127895095 | 4 | + | 26627737 | RPE1 | viability after 18 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | 0.431798996530792 | [268] | [51,146] | 2 | hSpCas9 | negative selection | 1400022 | 127885914 | 127885937 | 4 | + | 26627737 | HeLa | viability after 8 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | 0.9174201563290945 | [143] | [132,102,121] | 7 | hSpCas9 | negative selection | 1482332 | 127885998 | 127886021 | 4 | - | 26627737 | HeLa | viability after 8 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | 0.7384087106137744 | [824] | [846,370,630] | 6 | hSpCas9 | negative selection | 1482333 | 127887430 | 127887453 | 4 | - | 26627737 | HeLa | viability after 8 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.4579599838401738 | [850] | [554,603,385] | 4 | hSpCas9 | negative selection | 1482334 | 127891615 | 127891638 | 4 | - | 26627737 | HeLa | viability after 8 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -0.7527036781315423 | [275] | [53,113,43] | -6 | hSpCas9 | negative selection | 1482335 | 127893839 | 127893862 | 4 | + | 26627737 | HeLa | viability after 8 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | -1.5319305422438378 | [743] | [118,129,89] | -9 | hSpCas9 | negative selection | 1482336 | 127895072 | 127895095 | 4 | + | 26627737 | HeLa | viability after 8 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | 0.3676763023206277 | [236] | [133,170,96] | 3 | hSpCas9 | negative selection | 1482337 | 127885914 | 127885937 | 4 | + | 26627737 | HeLa | viability after 12 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | 0.7627135881220967 | [143] | [41,149,103] | 6 | hSpCas9 | negative selection | 1564647 | 127885998 | 127886021 | 4 | - | 26627737 | HeLa | viability after 12 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | 0.2871711701219697 | [824] | [316,370,561] | 2 | hSpCas9 | negative selection | 1564648 | 127887430 | 127887453 | 4 | - | 26627737 | HeLa | viability after 12 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.6282366867195008 | [850] | [600,613,409] | 5 | hSpCas9 | negative selection | 1564649 | 127891615 | 127891638 | 4 | - | 26627737 | HeLa | viability after 12 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -1.1323894580195857 | [275] | [15,42,96] | -8 | hSpCas9 | negative selection | 1564650 | 127893839 | 127893862 | 4 | + | 26627737 | HeLa | viability after 12 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | -0.28041135750172586 | [743] | [157,306,285] | -2 | hSpCas9 | negative selection | 1564651 | 127895072 | 127895095 | 4 | + | 26627737 | HeLa | viability after 12 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | 0.6703803317430627 | [236] | [204,146,117] | 5 | hSpCas9 | negative selection | 1564652 | 127885914 | 127885937 | 4 | + | 26627737 | HeLa | viability after 15 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | -0.5374569925498454 | [143] | [38,31,50] | -5 | hSpCas9 | negative selection | 1646962 | 127885998 | 127886021 | 4 | - | 26627737 | HeLa | viability after 15 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | 0.6262469722324617 | [824] | [539,471,544] | 5 | hSpCas9 | negative selection | 1646963 | 127887430 | 127887453 | 4 | - | 26627737 | HeLa | viability after 15 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.4497491864573637 | [850] | [227,439,777] | 4 | hSpCas9 | negative selection | 1646964 | 127891615 | 127891638 | 4 | - | 26627737 | HeLa | viability after 15 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -0.5296653236179282 | [275] | [5,191,32] | -4 | hSpCas9 | negative selection | 1646965 | 127893839 | 127893862 | 4 | + | 26627737 | HeLa | viability after 15 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | -0.6172343360886603 | [743] | [180,196,215] | -5 | hSpCas9 | negative selection | 1646966 | 127895072 | 127895095 | 4 | + | 26627737 | HeLa | viability after 15 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | -0.11518990263798357 | [236] | [112,63,89] | -1 | hSpCas9 | negative selection | 1646967 | 127885914 | 127885937 | 4 | + | 26627737 | HeLa | viability after 18 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | -0.500567467207579 | [143] | [26,27,50] | -4 | hSpCas9 | negative selection | 1729277 | 127885998 | 127886021 | 4 | - | 26627737 | HeLa | viability after 18 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | 0.6282699666896194 | [824] | [353,402,544] | 5 | hSpCas9 | negative selection | 1729278 | 127887430 | 127887453 | 4 | - | 26627737 | HeLa | viability after 18 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.4524965134572272 | [850] | [154,363,777] | 4 | hSpCas9 | negative selection | 1729279 | 127891615 | 127891638 | 4 | - | 26627737 | HeLa | viability after 18 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -0.5297655716690043 | [275] | [3,158,32] | -5 | hSpCas9 | negative selection | 1729280 | 127893839 | 127893862 | 4 | + | 26627737 | HeLa | viability after 18 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | -0.6230379738681573 | [743] | [119,162,215] | -5 | hSpCas9 | negative selection | 1729281 | 127895072 | 127895095 | 4 | + | 26627737 | HeLa | viability after 18 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | -0.053373474295185575 | [236] | [76,60,89] | 0 | hSpCas9 | negative selection | 1729282 | 127885914 | 127885937 | 4 | + | 26627737 | HCT116 | viability after 6 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | -0.9095370463750518 | [248] | [54,1] | -5 | hSpCas9 | negative selection | 1811592 | 127885998 | 127886021 | 4 | - | 26627737 | HCT116 | viability after 6 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | 0.1500430057380897 | [1832] | [389,280] | 0 | hSpCas9 | negative selection | 1811593 | 127887430 | 127887453 | 4 | - | 26627737 | HCT116 | viability after 6 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.5620633852645249 | [1239] | [417,215] | 3 | hSpCas9 | negative selection | 1811594 | 127891615 | 127891638 | 4 | - | 26627737 | HCT116 | viability after 6 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -0.051007359048102774 | [812] | [36,170] | 0 | hSpCas9 | negative selection | 1811595 | 127893839 | 127893862 | 4 | + | 26627737 | HCT116 | viability after 6 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | 0.6168340722778959 | [1086] | [214,287] | 3 | hSpCas9 | negative selection | 1811596 | 127895072 | 127895095 | 4 | + | 26627737 | HCT116 | viability after 6 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | -0.602877929383165 | [219] | [54,4] | -3 | hSpCas9 | negative selection | 1811597 | 127885914 | 127885937 | 4 | + | 26627737 | HCT116 | viability after 8 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | 0.40105585694985035 | [128] | [69,103,106] | 4 | hSpCas9 | negative selection | 1893907 | 127885998 | 127886021 | 4 | - | 26627737 | HCT116 | viability after 8 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | 0.037988748461421196 | [767] | [478,453,371] | 0 | hSpCas9 | negative selection | 1893908 | 127887430 | 127887453 | 4 | - | 26627737 | HCT116 | viability after 8 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.06919452618106003 | [830] | [526,431,482] | 0 | hSpCas9 | negative selection | 1893909 | 127891615 | 127891638 | 4 | - | 26627737 | HCT116 | viability after 8 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -1.1336037180184722 | [357] | [77,58,131] | -8 | hSpCas9 | negative selection | 1893910 | 127893839 | 127893862 | 4 | + | 26627737 | HCT116 | viability after 8 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | -0.7895447335427079 | [687] | [169,342,144] | -7 | hSpCas9 | negative selection | 1893911 | 127895072 | 127895095 | 4 | + | 26627737 | HCT116 | viability after 8 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | -0.5094984781305196 | [196] | [121,65,41] | -6 | hSpCas9 | negative selection | 1893912 | 127885914 | 127885937 | 4 | + | 26627737 | HCT116 | viability after 9 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | 1.228055369794789 | [248] | [181,134] | 7 | hSpCas9 | negative selection | 1976222 | 127885998 | 127886021 | 4 | - | 26627737 | HCT116 | viability after 9 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | -1.0116336180357939 | [1832] | [287,206] | -6 | hSpCas9 | negative selection | 1976223 | 127887430 | 127887453 | 4 | - | 26627737 | HCT116 | viability after 9 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.034275224103380575 | [1239] | [347,331] | 0 | hSpCas9 | negative selection | 1976224 | 127891615 | 127891638 | 4 | - | 26627737 | HCT116 | viability after 9 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -3.998116883803001 | [812] | [7,17] | -9 | hSpCas9 | negative selection | 1976225 | 127893839 | 127893862 | 4 | + | 26627737 | HCT116 | viability after 9 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | -0.9938166343893717 | [1086] | [171,124] | -6 | hSpCas9 | negative selection | 1976226 | 127895072 | 127895095 | 4 | + | 26627737 | HCT116 | viability after 9 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | 0.19629987809553961 | [219] | [30,95] | 1 | hSpCas9 | negative selection | 1976227 | 127885914 | 127885937 | 4 | + | 26627737 | HCT116 | viability after 12 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | 0.6373825946847477 | [128] | [95,138,82] | 6 | hSpCas9 | negative selection | 2058537 | 127885998 | 127886021 | 4 | - | 26627737 | HCT116 | viability after 12 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | -0.15399679355529794 | [767] | [412,287,380] | -1 | hSpCas9 | negative selection | 2058538 | 127887430 | 127887453 | 4 | - | 26627737 | HCT116 | viability after 12 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.156471459231045 | [830] | [535,325,589] | 1 | hSpCas9 | negative selection | 2058539 | 127891615 | 127891638 | 4 | - | 26627737 | HCT116 | viability after 12 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -1.5146243822800756 | [357] | [108,34,48] | -9 | hSpCas9 | negative selection | 2058540 | 127893839 | 127893862 | 4 | + | 26627737 | HCT116 | viability after 12 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | -0.5906762804281785 | [687] | [267,288,161] | -6 | hSpCas9 | negative selection | 2058541 | 127895072 | 127895095 | 4 | + | 26627737 | HCT116 | viability after 12 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | -0.1805597161112974 | [196] | [55,84,135] | -2 | hSpCas9 | negative selection | 2058542 | 127885914 | 127885937 | 4 | + | 26627737 | HCT116 | viability after 15 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | 0.5059805502435815 | [128] | [94,165,53] | 5 | hSpCas9 | negative selection | 2140852 | 127885998 | 127886021 | 4 | - | 26627737 | HCT116 | viability after 15 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | -0.19512890353393897 | [767] | [438,227,493] | -2 | hSpCas9 | negative selection | 2140853 | 127887430 | 127887453 | 4 | - | 26627737 | HCT116 | viability after 15 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.188275631557405 | [830] | [763,341,551] | 2 | hSpCas9 | negative selection | 2140854 | 127891615 | 127891638 | 4 | - | 26627737 | HCT116 | viability after 15 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -1.8303791761591948 | [357] | [79,26,68] | -9 | hSpCas9 | negative selection | 2140855 | 127893839 | 127893862 | 4 | + | 26627737 | HCT116 | viability after 15 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | -0.6496360937750677 | [687] | [269,335,152] | -6 | hSpCas9 | negative selection | 2140856 | 127895072 | 127895095 | 4 | + | 26627737 | HCT116 | viability after 15 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | -0.4718018883910202 | [196] | [83,76,83] | -5 | hSpCas9 | negative selection | 2140857 | 127885914 | 127885937 | 4 | + | 26627737 | HCT116 | viability after 18 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | 0.7789162804571302 | [128] | [157,111,47] | 6 | hSpCas9 | negative selection | 2223167 | 127885998 | 127886021 | 4 | - | 26627737 | HCT116 | viability after 18 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | 0.10230671750287268 | [767] | [542,336,315] | 0 | hSpCas9 | negative selection | 2223168 | 127887430 | 127887453 | 4 | - | 26627737 | HCT116 | viability after 18 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.21101293547972233 | [830] | [580,340,481] | 1 | hSpCas9 | negative selection | 2223169 | 127891615 | 127891638 | 4 | - | 26627737 | HCT116 | viability after 18 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -1.3100200475324502 | [357] | [71,80,54] | -8 | hSpCas9 | negative selection | 2223170 | 127893839 | 127893862 | 4 | + | 26627737 | HCT116 | viability after 18 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | -0.5882235700098818 | [687] | [226,207,229] | -5 | hSpCas9 | negative selection | 2223171 | 127895072 | 127895095 | 4 | + | 26627737 | HCT116 | viability after 18 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | -0.6424352227494095 | [196] | [111,48,20] | -5 | hSpCas9 | negative selection | 2223172 | 127883456 | 127883479 | 4 | + | 24336569 | HL60 | viability | AGATAGCAATTATGTGTATCTGG | PLK4 | ENSG00000142731 | 0.38073572168640235 | [567] | [1564] | 3 | hSpCas9 | negative selection | 2284634 | 127883478 | 127883501 | 4 | + | 24336569 | HL60 | viability | GTATTAGAAATGTGCCATAATGG | PLK4 | ENSG00000142731 | -0.5311499646537037 | [1502] | [2200] | -5 | hSpCas9 | negative selection | 2284635 | 127883491 | 127883514 | 4 | + | 24336569 | HL60 | viability | GCCATAATGGAGAAATGAACAGG | PLK4 | ENSG00000142731 | 1.0092517184165308 | [442] | [1886] | 7 | hSpCas9 | negative selection | 2284636 | 127885716 | 127885739 | 4 | + | 24336569 | HL60 | viability | TTCATGCACCAGATCATCACAGG | PLK4 | ENSG00000142731 | 0.2913451632606501 | [467] | [1211] | 2 | hSpCas9 | negative selection | 2284637 | 127885724 | 127885747 | 4 | - | 24336569 | HL60 | viability | ACAACATCCCTGTGATGATCTGG | PLK4 | ENSG00000142731 | 0.9564653550034259 | [365] | [1502] | 7 | hSpCas9 | negative selection | 2284638 | 127885740 | 127885763 | 4 | + | 24336569 | HL60 | viability | ATGTTGTATCTTCATTCTCATGG | PLK4 | ENSG00000142731 | 1.3337160631782108 | [631] | [3370] | 8 | hSpCas9 | negative selection | 2284639 | 127885753 | 127885776 | 4 | + | 24336569 | HL60 | viability | ATTCTCATGGTATACTACACCGG | PLK4 | ENSG00000142731 | -1.6776320560579332 | [516] | [341] | -9 | hSpCas9 | negative selection | 2284640 | 127885772 | 127885795 | 4 | - | 24336569 | HL60 | viability | GGTTAGAAAGTGTGAGGTCCCGG | PLK4 | ENSG00000142731 | -1.798483417201922 | [1268] | [771] | -9 | hSpCas9 | negative selection | 2284641 | 127885778 | 127885801 | 4 | - | 24336569 | HL60 | viability | GTAGGAGGTTAGAAAGTGTGAGG | PLK4 | ENSG00000142731 | -2.6402841865478215 | [1749] | [593] | -9 | hSpCas9 | negative selection | 2284642 | 127885793 | 127885816 | 4 | - | 24336569 | HL60 | viability | TCATATTACGAGTCAGTAGGAGG | PLK4 | ENSG00000142731 | 0.20216010608182675 | [457] | [1114] | 2 | hSpCas9 | negative selection | 2284643 | 127883456 | 127883479 | 4 | + | 24336569 | KBM7 | viability | AGATAGCAATTATGTGTATCTGG | PLK4 | ENSG00000142731 | 0.564022583354445 | [835] | [3370] | 5 | hSpCas9 | negative selection | 2351811 | 127883478 | 127883501 | 4 | + | 24336569 | KBM7 | viability | GTATTAGAAATGTGCCATAATGG | PLK4 | ENSG00000142731 | -0.37291819163699746 | [818] | [1724] | -3 | hSpCas9 | negative selection | 2351812 | 127883491 | 127883514 | 4 | + | 24336569 | KBM7 | viability | GCCATAATGGAGAAATGAACAGG | PLK4 | ENSG00000142731 | -0.5898997365965931 | [659] | [1195] | -5 | hSpCas9 | negative selection | 2351813 | 127885716 | 127885739 | 4 | + | 24336569 | KBM7 | viability | TTCATGCACCAGATCATCACAGG | PLK4 | ENSG00000142731 | -0.37940769390730333 | [402] | [844] | -3 | hSpCas9 | negative selection | 2351814 | 127885724 | 127885747 | 4 | - | 24336569 | KBM7 | viability | ACAACATCCCTGTGATGATCTGG | PLK4 | ENSG00000142731 | 0.4814051699102526 | [431] | [1644] | 4 | hSpCas9 | negative selection | 2351815 | 127885740 | 127885763 | 4 | + | 24336569 | KBM7 | viability | ATGTTGTATCTTCATTCTCATGG | PLK4 | ENSG00000142731 | 0.17993235443427846 | [489] | [1513] | 1 | hSpCas9 | negative selection | 2351816 | 127885753 | 127885776 | 4 | + | 24336569 | KBM7 | viability | ATTCTCATGGTATACTACACCGG | PLK4 | ENSG00000142731 | -4.711524107329836 | [316] | [32] | -9 | hSpCas9 | negative selection | 2351817 | 127885772 | 127885795 | 4 | - | 24336569 | KBM7 | viability | GGTTAGAAAGTGTGAGGTCCCGG | PLK4 | ENSG00000142731 | -4.597535781758599 | [860] | [96] | -9 | hSpCas9 | negative selection | 2351818 | 127885778 | 127885801 | 4 | - | 24336569 | KBM7 | viability | GTAGGAGGTTAGAAAGTGTGAGG | PLK4 | ENSG00000142731 | -3.886289524812094 | [1105] | [203] | -9 | hSpCas9 | negative selection | 2351819 | 127885793 | 127885816 | 4 | - | 24336569 | KBM7 | viability | TCATATTACGAGTCAGTAGGAGG | PLK4 | ENSG00000142731 | -2.8940949273008942 | [694] | [254] | -9 | hSpCas9 | negative selection | 2351820 | 127881142 | 127881165 | 4 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CTCGATCTTCTCCCCGATGCAGG | PLK4 | ENSG00000142731 | 0.2089070579380785 | [338,130] | [110,2] | 1 | dCas9-VP64 | positive selection | 2408738 | 127881097 | 127881120 | 4 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GAAGCTAATCCGGAGAACCCAGG | PLK4 | ENSG00000142731 | -0.7412401434677743 | [91,13] | [6,4] | -4 | dCas9-VP64 | positive selection | 2408739 | 127881075 | 127881098 | 4 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GCCTCGAAGGGACTGCGTGAAGG | PLK4 | ENSG00000142731 | -1.122446682175581 | [722,30] | [60,10] | -6 | dCas9-VP64 | positive selection | 2408740 | 127882712 | 127882735 | 4 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CGCGCCATTGCACTCCAGCCCAG | PLK4 | ENSG00000142731 | 0.6055497745369944 | [158,1336] | [33,490] | 2 | dCas9-VP64 | positive selection | 2451198 | 127881142 | 127881165 | 4 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CTCGATCTTCTCCCCGATGCAGG | PLK4 | ENSG00000142731 | -0.4587915190684104 | [133,226] | [40,43] | -5 | dCas9-VP64 | positive selection | 2503993 | 127881097 | 127881120 | 4 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GAAGCTAATCCGGAGAACCCAGG | PLK4 | ENSG00000142731 | 0.7017513532268488 | [44,105] | [52,26] | 5 | dCas9-VP64 | positive selection | 2503994 | 127881075 | 127881098 | 4 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GCCTCGAAGGGACTGCGTGAAGG | PLK4 | ENSG00000142731 | -0.5871388615254319 | [149,212] | [41,35] | -6 | dCas9-VP64 | positive selection | 2503995 | 127882712 | 127882735 | 4 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CGCGCCATTGCACTCCAGCCCAG | PLK4 | ENSG00000142731 | 0.3847800892193698 | [535,417] | [146,256] | 3 | dCas9-VP64 | positive selection | 2546453 | 127886503 | 127886526 | 4 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | AGAAGTGCCAGATCTATCAGAGG | PLK4 | ENSG00000142731 | 0.4100201697175931 | [3,3] | [4,3] | 8 | hSpCas9 | positive selection | 3012021 | 127885778 | 127885801 | 4 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | GTAGGAGGTTAGAAAGTGTGAGG | PLK4 | ENSG00000142731 | 0.2029618388514867 | [3,2] | [3,2] | 4 | hSpCas9 | positive selection | 3012022 | 127885718 | 127885741 | 4 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | TCATGCACCAGATCATCACAGGG | PLK4 | ENSG00000142731 | -0.43109270771531494 | [0,1] | [0,0] | -6 | hSpCas9 | positive selection | 3012023 | 127885998 | 127886021 | 4 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | -0.5587418575738695 | [3,3] | [0,2] | -7 | hSpCas9 | positive selection | 3012024 | 127886503 | 127886526 | 4 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | AGAAGTGCCAGATCTATCAGAGG | PLK4 | ENSG00000142731 | 0.09557911268905411 | [3,3] | [2,2] | 1 | hSpCas9 | positive selection | 3079879 | 127885778 | 127885801 | 4 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | GTAGGAGGTTAGAAAGTGTGAGG | PLK4 | ENSG00000142731 | 0.33732472594765295 | [3,3] | [1,3] | 6 | hSpCas9 | positive selection | 3079880 | 127885718 | 127885741 | 4 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | TCATGCACCAGATCATCACAGGG | PLK4 | ENSG00000142731 | 0.6053709083741194 | [0,0] | [2,0] | 8 | hSpCas9 | positive selection | 3079881 | 127885998 | 127886021 | 4 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | -0.4414445584812624 | [3,3] | [2,0] | -6 | hSpCas9 | positive selection | 3079882 | 127881882 | 127881905 | | + | 24336571 | A375 | resistance to PLX after 7 days | AGAGCTGAGTCCATTCACACTGG | PLK4 | ENSG00000142731 | 0.739837040596957 | [8,7] | [14,14] | 9 | hSpCas9 | positive selection | 3136289 | 127887394 | 127887417 | | + | 24336571 | A375 | resistance to PLX after 7 days | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.20822338502346316 | [35,29] | [37,37] | 6 | hSpCas9 | positive selection | 3136290 | 127881852 | 127881875 | | + | 24336571 | A375 | resistance to PLX after 7 days | CTTGGTAAAGGATCATTTGCTGG | PLK4 | ENSG00000142731 | 0.2616514357337696 | [28,24] | [34,28] | 7 | hSpCas9 | positive selection | 3136291 | 127887430 | 127887453 | | - | 24336571 | A375 | resistance to PLX after 7 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.01045250387871044 | [23,26] | [26,24] | 0 | hSpCas9 | positive selection | 3136292 | 127881905 | 127881928 | | + | 24336571 | A375 | resistance to PLX after 7 days | TTTGGAAGTTGCAATCAAAATGG | PLK4 | ENSG00000142731 | -0.2061433866385869 | [2,2] | [2,1] | -6 | hSpCas9 | positive selection | 3136293 | 127881882 | 127881905 | | + | 24336571 | A375 | resistance to PLX after 14 days | AGAGCTGAGTCCATTCACACTGG | PLK4 | ENSG00000142731 | 0.7254213875349622 | [6,7] | [5,4] | 6 | hSpCas9 | positive selection | 3194082 | 127887394 | 127887417 | | + | 24336571 | A375 | resistance to PLX after 14 days | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 1.9938501756522 | [28,33] | [58,59] | 9 | hSpCas9 | positive selection | 3194083 | 127881852 | 127881875 | | + | 24336571 | A375 | resistance to PLX after 14 days | CTTGGTAAAGGATCATTTGCTGG | PLK4 | ENSG00000142731 | 0.7513923453194876 | [21,19] | [15,16] | 6 | hSpCas9 | positive selection | 3194084 | 127887430 | 127887453 | | - | 24336571 | A375 | resistance to PLX after 14 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 7.160808160326698 | [29,29] | [96,3971] | 9 | hSpCas9 | positive selection | 3194085 | 127881905 | 127881928 | | + | 24336571 | A375 | resistance to PLX after 14 days | TTTGGAAGTTGCAATCAAAATGG | PLK4 | ENSG00000142731 | 0.704596482576568 | [1,1] | [1,1] | 6 | hSpCas9 | positive selection | 3194086 | 127881882 | 127881905 | | + | 24336571 | A375 | viability after 7 days | AGAGCTGAGTCCATTCACACTGG | PLK4 | ENSG00000142731 | -1.8341358212208778 | [33] | [8,7] | -9 | hSpCas9 | negative selection | 3251875 | 127887394 | 127887417 | | + | 24336571 | A375 | viability after 7 days | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | -0.6502444713828401 | [53] | [35,29] | -7 | hSpCas9 | negative selection | 3251876 | 127881852 | 127881875 | | + | 24336571 | A375 | viability after 7 days | CTTGGTAAAGGATCATTTGCTGG | PLK4 | ENSG00000142731 | -0.047089140576872524 | [28] | [28,24] | 0 | hSpCas9 | negative selection | 3251877 | 127887430 | 127887453 | | - | 24336571 | A375 | viability after 7 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.04635102593967644 | [25] | [23,26] | 0 | hSpCas9 | negative selection | 3251878 | 127881905 | 127881928 | | + | 24336571 | A375 | viability after 7 days | TTTGGAAGTTGCAATCAAAATGG | PLK4 | ENSG00000142731 | -0.28758999231006754 | [3] | [2,2] | -4 | hSpCas9 | negative selection | 3251879 | 127881882 | 127881905 | | + | 24336571 | A375 | viability after 14 days | AGAGCTGAGTCCATTCACACTGG | PLK4 | ENSG00000142731 | -2.0617354225769127 | [33] | [6,7] | -9 | hSpCas9 | negative selection | 3309668 | 127887394 | 127887417 | | + | 24336571 | A375 | viability after 14 days | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | -0.6803842540925407 | [53] | [28,33] | -7 | hSpCas9 | negative selection | 3309669 | 127881852 | 127881875 | | + | 24336571 | A375 | viability after 14 days | CTTGGTAAAGGATCATTTGCTGG | PLK4 | ENSG00000142731 | -0.37151434766644054 | [28] | [21,19] | -4 | hSpCas9 | negative selection | 3309670 | 127887430 | 127887453 | | - | 24336571 | A375 | viability after 14 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.2795274203449686 | [25] | [29,29] | 3 | hSpCas9 | negative selection | 3309671 | 127881905 | 127881928 | | + | 24336571 | A375 | viability after 14 days | TTTGGAAGTTGCAATCAAAATGG | PLK4 | ENSG00000142731 | -0.5693519411577728 | [3] | [1,1] | -6 | hSpCas9 | negative selection | 3309672 | 127893588 | 127893611 | 4 | - | 27383988 | 293T | resistance to West Nile virus (flavivirus) | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | -2.67488854052255 | [976,976] | [0,0] | -9 | hSpCas9 | positive selection | 3386375 | 127887394 | 127887417 | 4 | + | 27383988 | 293T | resistance to West Nile virus (flavivirus) | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | -1.8590177497916331 | [554,554] | [0,0] | -9 | hSpCas9 | positive selection | 3386376 | 127887461 | 127887484 | 4 | - | 27383988 | 293T | resistance to West Nile virus (flavivirus) | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | 0.28004628794591846 | [125,125] | [0,0] | 1 | hSpCas9 | positive selection | 3386377 | 127886503 | 127886526 | 4 | - | 26780180 | HT29 | viability (Avana library 4 designs) | AGAAGTGCCAGATCTATCAGAGG | PLK4 | ENSG00000142731 | 1.5555215792982 | [] | [] | 6 | hSpCas9 | negative selection | 3450120 | 127885778 | 127885801 | 4 | - | 26780180 | HT29 | viability (Avana library 4 designs) | GTAGGAGGTTAGAAAGTGTGAGG | PLK4 | ENSG00000142731 | 5.57518696777846 | [] | [] | 9 | hSpCas9 | negative selection | 3450121 | 127885717 | 127885740 | 4 | + | 26780180 | HT29 | viability (Avana library 4 designs) | TCATGCACCAGATCATCACAGGG | PLK4 | ENSG00000142731 | 5.20311344578077 | [] | [] | 9 | hSpCas9 | negative selection | 3450122 | 127885998 | 127886021 | 4 | - | 26780180 | HT29 | viability (Avana library 4 designs) | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | 3.64592679931817 | [] | [] | 9 | hSpCas9 | negative selection | 3450123 | 127885717 | 127885740 | 4 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | TCATGCACCAGATCATCACAGGG | PLK4 | ENSG00000142731 | -19.1010576560719 | [] | [] | -9 | hSpCas9 | negative selection | 3545210 | 127885998 | 127886021 | 4 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | 3.17819310967046 | [] | [] | 5 | hSpCas9 | negative selection | 3545211 | 127885778 | 127885801 | 4 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GTAGGAGGTTAGAAAGTGTGAGG | PLK4 | ENSG00000142731 | -11.4592295714924 | [] | [] | -8 | hSpCas9 | negative selection | 3545212 | 127886503 | 127886526 | 4 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | AGAAGTGCCAGATCTATCAGAGG | PLK4 | ENSG00000142731 | -3.83999069008021 | [] | [] | -4 | hSpCas9 | negative selection | 3545213 | 127885793 | 127885816 | 4 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | TCATATTACGAGTCAGTAGGAGG | PLK4 | ENSG00000142731 | -20.204413653531 | [] | [] | -9 | hSpCas9 | negative selection | 3545214 | 127885995 | 127886018 | 4 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | ACTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -8.43776103857123 | [] | [] | -7 | hSpCas9 | negative selection | 3545215 | 127885717 | 127885740 | 4 | + | 26780180 | A375 | viability (Avana lentiGuide) | TCATGCACCAGATCATCACAGGG | PLK4 | ENSG00000142731 | 20.6327359564281 | [] | [] | 8 | hSpCas9 | negative selection | 3653869 | 127885998 | 127886021 | 4 | - | 26780180 | A375 | viability (Avana lentiGuide) | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | 16.2594684097805 | [] | [] | 8 | hSpCas9 | negative selection | 3653870 | 127885778 | 127885801 | 4 | - | 26780180 | A375 | viability (Avana lentiGuide) | GTAGGAGGTTAGAAAGTGTGAGG | PLK4 | ENSG00000142731 | 24.2326390076571 | [] | [] | 9 | hSpCas9 | negative selection | 3653871 | 127886503 | 127886526 | 4 | - | 26780180 | A375 | viability (Avana lentiGuide) | AGAAGTGCCAGATCTATCAGAGG | PLK4 | ENSG00000142731 | 1.08793787149254 | [] | [] | 1 | hSpCas9 | negative selection | 3653872 | 127885793 | 127885816 | 4 | - | 26780180 | A375 | viability (Avana lentiGuide) | TCATATTACGAGTCAGTAGGAGG | PLK4 | ENSG00000142731 | 14.067832105430501 | [] | [] | 7 | hSpCas9 | negative selection | 3653873 | 127885995 | 127886018 | 4 | - | 26780180 | A375 | viability (Avana lentiGuide) | ACTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | 17.7195563631437 | [] | [] | 8 | hSpCas9 | negative selection | 3653874 | 127885717 | 127885740 | 4 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | TCATGCACCAGATCATCACAGGG | PLK4 | ENSG00000142731 | -1.2598738437628823 | [5] | [2,0] | -9 | hSpCas9 | positive selection | 3762528 | 127885998 | 127886021 | 4 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | 0.10531263967427977 | [5] | [6,4] | 2 | hSpCas9 | positive selection | 3762529 | 127885778 | 127885801 | 4 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GTAGGAGGTTAGAAAGTGTGAGG | PLK4 | ENSG00000142731 | -1.169941071316482 | [5] | [1,1] | -9 | hSpCas9 | positive selection | 3762530 | 127886503 | 127886526 | 4 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | AGAAGTGCCAGATCTATCAGAGG | PLK4 | ENSG00000142731 | -0.14409736264419454 | [5] | [5,4] | -2 | hSpCas9 | positive selection | 3762531 | 127885793 | 127885816 | 4 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | TCATATTACGAGTCAGTAGGAGG | PLK4 | ENSG00000142731 | -0.9140264713570433 | [5] | [2,2] | -8 | hSpCas9 | positive selection | 3762532 | 127885995 | 127886018 | 4 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | ACTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -0.13036824535533337 | [4] | [3,4] | -2 | hSpCas9 | positive selection | 3762533 | 127885717 | 127885740 | 4 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | TCATGCACCAGATCATCACAGGG | PLK4 | ENSG00000142731 | -1.198654330233919 | [5] | [1,1] | -9 | hSpCas9 | positive selection | 3871135 | 127885998 | 127886021 | 4 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | -0.44758970298287165 | [5] | [4,1] | -5 | hSpCas9 | positive selection | 3871136 | 127885778 | 127885801 | 4 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GTAGGAGGTTAGAAAGTGTGAGG | PLK4 | ENSG00000142731 | -1.1663883514638995 | [5] | [0,3] | -8 | hSpCas9 | positive selection | 3871137 | 127886503 | 127886526 | 4 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | AGAAGTGCCAGATCTATCAGAGG | PLK4 | ENSG00000142731 | -0.010439821074369068 | [5] | [3,4] | 0 | hSpCas9 | positive selection | 3871138 | 127885793 | 127885816 | 4 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | TCATATTACGAGTCAGTAGGAGG | PLK4 | ENSG00000142731 | -1.2590017061681138 | [5] | [0,1] | -9 | hSpCas9 | positive selection | 3871139 | 127885995 | 127886018 | 4 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | ACTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -0.8400744726665842 | [5] | [4,0] | -8 | hSpCas9 | positive selection | 3871140 | 127887452 | 127887475 | 4 | + | 26780180 | A375 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | 1.123924825113 | [] | [] | 5 | hSpCas9 | negative selection | 3981965 | 127887394 | 127887417 | 4 | + | 26780180 | A375 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 1.31424942352856 | [] | [] | 7 | hSpCas9 | negative selection | 3981966 | 127887461 | 127887484 | 4 | - | 26780180 | A375 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | 1.07789410762951 | [] | [] | 5 | hSpCas9 | negative selection | 3981967 | 127893588 | 127893611 | 4 | - | 26780180 | A375 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.0632735101615727 | [] | [] | 0 | hSpCas9 | negative selection | 3981968 | 127893515 | 127893538 | 4 | + | 26780180 | A375 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | 1.44474164712499 | [] | [] | 8 | hSpCas9 | negative selection | 3981969 | 127887430 | 127887453 | 4 | - | 26780180 | A375 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 1.71223271822716 | [] | [] | 9 | hSpCas9 | negative selection | 3981970 | 127887452 | 127887475 | 4 | + | 26780180 | HT29 | viability (GeCKOv2 library) | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | 1.5765683399038 | [] | [] | 8 | hSpCas9 | negative selection | 4089931 | 127887394 | 127887417 | 4 | + | 26780180 | HT29 | viability (GeCKOv2 library) | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.513465811393617 | [] | [] | 1 | hSpCas9 | negative selection | 4089932 | 127887461 | 127887484 | 4 | - | 26780180 | HT29 | viability (GeCKOv2 library) | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | 1.62706078909465 | [] | [] | 8 | hSpCas9 | negative selection | 4089933 | 127893588 | 127893611 | 4 | - | 26780180 | HT29 | viability (GeCKOv2 library) | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | -0.190165087403837 | [] | [] | -5 | hSpCas9 | negative selection | 4089934 | 127893515 | 127893538 | 4 | + | 26780180 | HT29 | viability (GeCKOv2 library) | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | 1.9013047386837 | [] | [] | 9 | hSpCas9 | negative selection | 4089935 | 127887430 | 127887453 | 4 | - | 26780180 | HT29 | viability (GeCKOv2 library) | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 1.50803470041072 | [] | [] | 7 | hSpCas9 | negative selection | 4089936 | 127881882 | 127881905 | 4 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) | AGAGCTGAGTCCATTCACACTGG | PLK4 | ENSG00000142731 | 0.09975601793498215 | [3] | [2,2] | 2 | hSpCas9 | positive selection | 4161309 | 127887394 | 127887417 | 4 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.3775791386139153 | [4] | [2,5] | 8 | hSpCas9 | positive selection | 4161310 | 127881852 | 127881875 | 4 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) | CTTGGTAAAGGATCATTTGCTGG | PLK4 | ENSG00000142731 | 0.21662119025972632 | [4] | [3,3] | 5 | hSpCas9 | positive selection | 4161311 | 127887430 | 127887453 | 4 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.7179185950981988 | [5] | [3,9] | 9 | hSpCas9 | positive selection | 4161312 | 127881905 | 127881928 | 4 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) | TTTGGAAGTTGCAATCAAAATGG | PLK4 | ENSG00000142731 | -0.8065626722980601 | [2] | [0,0] | -9 | hSpCas9 | positive selection | 4161313 | 127881882 | 127881905 | 4 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiGuide) | AGAGCTGAGTCCATTCACACTGG | PLK4 | ENSG00000142731 | -0.4120135087035965 | [4] | [2,2,0,0] | -6 | hSpCas9 | positive selection | 4225331 | 127887394 | 127887417 | 4 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiGuide) | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.8200150963421806 | [5] | [3,3,2,4] | 5 | hSpCas9 | positive selection | 4225332 | 127881852 | 127881875 | 4 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiGuide) | CTTGGTAAAGGATCATTTGCTGG | PLK4 | ENSG00000142731 | 0.5406044185407641 | [4] | [0,3,0,3] | 4 | hSpCas9 | positive selection | 4225333 | 127887430 | 127887453 | 4 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiGuide) | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.44033590751776375 | [4] | [4,3,4,0] | 3 | hSpCas9 | positive selection | 4225334 | 127881905 | 127881928 | 4 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiGuide) | TTTGGAAGTTGCAATCAAAATGG | PLK4 | ENSG00000142731 | 0.1354965131518151 | [1] | [0,1,0,0] | 1 | hSpCas9 | positive selection | 4225335 | 127887430 | 127887453 | 4 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.007594117379552498 | [3] | [2,1] | 0 | hSpCas9 | positive selection | 4290846 | 127893515 | 127893538 | 4 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.4595549887726914 | [2] | [1,0] | -7 | hSpCas9 | positive selection | 4290847 | 127887452 | 127887475 | 4 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.9887137165233484 | [1] | [0,0] | -9 | hSpCas9 | positive selection | 4290848 | 127893588 | 127893611 | 4 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.2605143901721214 | [4] | [5,3] | 5 | hSpCas9 | positive selection | 4355097 | 127887394 | 127887417 | 4 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | -0.24535674508914926 | [4] | [3,1] | -5 | hSpCas9 | positive selection | 4355098 | 127887461 | 127887484 | 4 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.2423274954619964 | [2] | [1,1] | -5 | hSpCas9 | positive selection | 4355099 | 127885755 | 127885777 | 4 | + | 27760321 | OCIAML3 | viability | TCTCATGGTATACTACACCGGG | PLK4 | ENSG00000142731 | -3.7082027056140925 | [110,96] | [0,12] | -9 | hSpCas9 | negative selection | 4428689 | 127885793 | 127885815 | 4 | - | 27760321 | OCIAML3 | viability | CATATTACGAGTCAGTAGGAGG | PLK4 | ENSG00000142731 | -1.1957434315194504 | [302,274] | [95,101] | -8 | hSpCas9 | negative selection | 4428690 | 127885995 | 127886017 | 4 | - | 27760321 | OCIAML3 | viability | CTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -0.7371814450484734 | [492,471] | [158,314] | -6 | hSpCas9 | negative selection | 4428691 | 127886090 | 127886112 | 4 | - | 27760321 | OCIAML3 | viability | ACGAAGTAACTGGTGAATAAGG | PLK4 | ENSG00000142731 | 0.8478900969619083 | [68,54] | [94,75] | 8 | hSpCas9 | negative selection | 4428692 | 127886472 | 127886494 | 4 | - | 27760321 | OCIAML3 | viability | TACGAAGGTATCGAGAATGTGG | PLK4 | ENSG00000142731 | -3.104133031055065 | [86,83] | [12,0] | -9 | hSpCas9 | negative selection | 4428693 | 127885755 | 127885777 | 4 | + | 27760321 | OCIAML2 | viability | TCTCATGGTATACTACACCGGG | PLK4 | ENSG00000142731 | -2.213794343911519 | [110,96] | [24,8] | -9 | hSpCas9 | negative selection | 4512152 | 127885793 | 127885815 | 4 | - | 27760321 | OCIAML2 | viability | CATATTACGAGTCAGTAGGAGG | PLK4 | ENSG00000142731 | -1.380681875125307 | [302,274] | [46,145] | -8 | hSpCas9 | negative selection | 4512153 | 127885995 | 127886017 | 4 | - | 27760321 | OCIAML2 | viability | CTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -0.2689008582591401 | [492,471] | [260,407] | -3 | hSpCas9 | negative selection | 4512154 | 127886090 | 127886112 | 4 | - | 27760321 | OCIAML2 | viability | ACGAAGTAACTGGTGAATAAGG | PLK4 | ENSG00000142731 | 0.07723974883734419 | [68,54] | [27,84] | 1 | hSpCas9 | negative selection | 4512155 | 127886472 | 127886494 | 4 | - | 27760321 | OCIAML2 | viability | TACGAAGGTATCGAGAATGTGG | PLK4 | ENSG00000142731 | -1.5584119225355928 | [86,83] | [29,14] | -8 | hSpCas9 | negative selection | 4512156 | 127885755 | 127885777 | 4 | + | 27760321 | MV411 | viability | TCTCATGGTATACTACACCGGG | PLK4 | ENSG00000142731 | -2.0111878429350583 | [110,96] | [0,40] | -8 | hSpCas9 | negative selection | 4595615 | 127885793 | 127885815 | 4 | - | 27760321 | MV411 | viability | CATATTACGAGTCAGTAGGAGG | PLK4 | ENSG00000142731 | -2.8966244462518373 | [302,274] | [15,39] | -9 | hSpCas9 | negative selection | 4595616 | 127885995 | 127886017 | 4 | - | 27760321 | MV411 | viability | CTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | 0.39999221962441944 | [492,471] | [373,490] | 3 | hSpCas9 | negative selection | 4595617 | 127886090 | 127886112 | 4 | - | 27760321 | MV411 | viability | ACGAAGTAACTGGTGAATAAGG | PLK4 | ENSG00000142731 | -5.345858925135197 | [68,54] | [0,0] | -9 | hSpCas9 | negative selection | 4595618 | 127886472 | 127886494 | 4 | - | 27760321 | MV411 | viability | TACGAAGGTATCGAGAATGTGG | PLK4 | ENSG00000142731 | -5.820831671955491 | [86,83] | [0,0] | -9 | hSpCas9 | negative selection | 4595619 | 127885755 | 127885777 | 4 | + | 27760321 | HL60 | viability | TCTCATGGTATACTACACCGGG | PLK4 | ENSG00000142731 | -1.7337979292746422 | [110,96] | [24,25] | -9 | hSpCas9 | negative selection | 4679078 | 127885793 | 127885815 | 4 | - | 27760321 | HL60 | viability | CATATTACGAGTCAGTAGGAGG | PLK4 | ENSG00000142731 | -1.4638064961281032 | [302,274] | [102,66] | -8 | hSpCas9 | negative selection | 4679079 | 127885995 | 127886017 | 4 | - | 27760321 | HL60 | viability | CTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -0.5766878844772945 | [492,471] | [203,328] | -6 | hSpCas9 | negative selection | 4679080 | 127886090 | 127886112 | 4 | - | 27760321 | HL60 | viability | ACGAAGTAACTGGTGAATAAGG | PLK4 | ENSG00000142731 | -2.772416701078874 | [68,54] | [2,11] | -9 | hSpCas9 | negative selection | 4679081 | 127886472 | 127886494 | 4 | - | 27760321 | HL60 | viability | TACGAAGGTATCGAGAATGTGG | PLK4 | ENSG00000142731 | -3.5507990222546137 | [86,83] | [4,6] | -9 | hSpCas9 | negative selection | 4679082 | 127885755 | 127885777 | 4 | + | 27760321 | HT1080 | viability | TCTCATGGTATACTACACCGGG | PLK4 | ENSG00000142731 | -5.107158541575956 | [96,75] | [0,0] | -8 | hSpCas9 | negative selection | 4762541 | 127885793 | 127885815 | 4 | - | 27760321 | HT1080 | viability | CATATTACGAGTCAGTAGGAGG | PLK4 | ENSG00000142731 | -6.6089757488120675 | [274,214] | [0,0] | -9 | hSpCas9 | negative selection | 4762542 | 127885995 | 127886017 | 4 | - | 27760321 | HT1080 | viability | CTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -7.388295399815306 | [471,368] | [0,0] | -9 | hSpCas9 | negative selection | 4762543 | 127886090 | 127886112 | 4 | - | 27760321 | HT1080 | viability | ACGAAGTAACTGGTGAATAAGG | PLK4 | ENSG00000142731 | -4.287047653924705 | [54,42] | [0,0] | -8 | hSpCas9 | negative selection | 4762544 | 127886472 | 127886494 | 4 | - | 27760321 | HT1080 | viability | TACGAAGGTATCGAGAATGTGG | PLK4 | ENSG00000142731 | -4.901600504460669 | [83,65] | [0,0] | -8 | hSpCas9 | negative selection | 4762545 | 127885755 | 127885777 | 4 | + | 27760321 | HT29 | viability after 7 days | TCTCATGGTATACTACACCGGG | PLK4 | ENSG00000142731 | -1.7790105872506197 | [96,75] | [53,36,9] | -9 | hSpCas9 | negative selection | 4846004 | 127885793 | 127885815 | 4 | - | 27760321 | HT29 | viability after 7 days | CATATTACGAGTCAGTAGGAGG | PLK4 | ENSG00000142731 | -1.6346181825840962 | [274,214] | [128,40,136] | -9 | hSpCas9 | negative selection | 4846005 | 127885995 | 127886017 | 4 | - | 27760321 | HT29 | viability after 7 days | CTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -0.7098759393008938 | [471,368] | [499,267,249] | -7 | hSpCas9 | negative selection | 4846006 | 127886090 | 127886112 | 4 | - | 27760321 | HT29 | viability after 7 days | ACGAAGTAACTGGTGAATAAGG | PLK4 | ENSG00000142731 | -0.6391995398285601 | [54,42] | [70,24,29] | -7 | hSpCas9 | negative selection | 4846007 | 127886472 | 127886494 | 4 | - | 27760321 | HT29 | viability after 7 days | TACGAAGGTATCGAGAATGTGG | PLK4 | ENSG00000142731 | -2.4419501545637528 | [83,65] | [26,23,3] | -9 | hSpCas9 | negative selection | 4846008 | 127885755 | 127885777 | 4 | + | 27760321 | HT29 | viability after 25 days | TCTCATGGTATACTACACCGGG | PLK4 | ENSG00000142731 | -6.6268408064224795 | [96,75] | [0,0,0] | -9 | hSpCas9 | negative selection | 4929467 | 127885793 | 127885815 | 4 | - | 27760321 | HT29 | viability after 25 days | CATATTACGAGTCAGTAGGAGG | PLK4 | ENSG00000142731 | -7.685858719025961 | [274,214] | [1,0,0] | -9 | hSpCas9 | negative selection | 4929468 | 127885995 | 127886017 | 4 | - | 27760321 | HT29 | viability after 25 days | CTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -3.700909725859172 | [471,368] | [9,69,31] | -9 | hSpCas9 | negative selection | 4929469 | 127886090 | 127886112 | 4 | - | 27760321 | HT29 | viability after 25 days | ACGAAGTAACTGGTGAATAAGG | PLK4 | ENSG00000142731 | -5.806729918771229 | [54,42] | [0,0,0] | -9 | hSpCas9 | negative selection | 4929470 | 127886472 | 127886494 | 4 | - | 27760321 | HT29 | viability after 25 days | TACGAAGGTATCGAGAATGTGG | PLK4 | ENSG00000142731 | -1.6018922629049737 | [83,65] | [37,9,36] | -7 | hSpCas9 | negative selection | 4929471 | 127885755 | 127885777 | 4 | + | 27760321 | HT29 | viability after 22 days | TCTCATGGTATACTACACCGGG | PLK4 | ENSG00000142731 | -6.644159438281739 | [96,75] | [0,0,0] | -9 | hSpCas9 | negative selection | 5012930 | 127885793 | 127885815 | 4 | - | 27760321 | HT29 | viability after 22 days | CATATTACGAGTCAGTAGGAGG | PLK4 | ENSG00000142731 | -8.145976645517852 | [274,214] | [0,0,0] | -9 | hSpCas9 | negative selection | 5012931 | 127885995 | 127886017 | 4 | - | 27760321 | HT29 | viability after 22 days | CTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -3.3991432821286356 | [471,368] | [26,40,70] | -9 | hSpCas9 | negative selection | 5012932 | 127886090 | 127886112 | 4 | - | 27760321 | HT29 | viability after 22 days | ACGAAGTAACTGGTGAATAAGG | PLK4 | ENSG00000142731 | -5.824048550630488 | [54,42] | [0,0,0] | -9 | hSpCas9 | negative selection | 5012933 | 127886472 | 127886494 | 4 | - | 27760321 | HT29 | viability after 22 days | TACGAAGGTATCGAGAATGTGG | PLK4 | ENSG00000142731 | -1.8301014041045591 | [83,65] | [5,9,57] | -8 | hSpCas9 | negative selection | 5012934 | 127885755 | 127885777 | 4 | + | 27760321 | HT29 | viability after 19 days | TCTCATGGTATACTACACCGGG | PLK4 | ENSG00000142731 | -6.628319385858526 | [96,75] | [0,0,0] | -9 | hSpCas9 | negative selection | 5096393 | 127885793 | 127885815 | 4 | - | 27760321 | HT29 | viability after 19 days | CATATTACGAGTCAGTAGGAGG | PLK4 | ENSG00000142731 | -8.130136593094639 | [274,214] | [0,0,0] | -9 | hSpCas9 | negative selection | 5096394 | 127885995 | 127886017 | 4 | - | 27760321 | HT29 | viability after 19 days | CTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -5.561459647497233 | [471,368] | [5,10,12] | -9 | hSpCas9 | negative selection | 5096395 | 127886090 | 127886112 | 4 | - | 27760321 | HT29 | viability after 19 days | ACGAAGTAACTGGTGAATAAGG | PLK4 | ENSG00000142731 | -5.808208498207275 | [54,42] | [0,0,0] | -9 | hSpCas9 | negative selection | 5096396 | 127886472 | 127886494 | 4 | - | 27760321 | HT29 | viability after 19 days | TACGAAGGTATCGAGAATGTGG | PLK4 | ENSG00000142731 | 0.2705023709548009 | [83,65] | [46,219,39] | 2 | hSpCas9 | negative selection | 5096397 | 127885755 | 127885777 | 4 | + | 27760321 | HT29 | viability after 16 days | TCTCATGGTATACTACACCGGG | PLK4 | ENSG00000142731 | -6.596854933437604 | [96,75] | [0,0,0] | -9 | hSpCas9 | negative selection | 5179856 | 127885793 | 127885815 | 4 | - | 27760321 | HT29 | viability after 16 days | CATATTACGAGTCAGTAGGAGG | PLK4 | ENSG00000142731 | -7.7103373845070395 | [274,214] | [1,0,0] | -9 | hSpCas9 | negative selection | 5179857 | 127885995 | 127886017 | 4 | - | 27760321 | HT29 | viability after 16 days | CTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -3.2290212324380363 | [471,368] | [3,94,45] | -9 | hSpCas9 | negative selection | 5179858 | 127886090 | 127886112 | 4 | - | 27760321 | HT29 | viability after 16 days | ACGAAGTAACTGGTGAATAAGG | PLK4 | ENSG00000142731 | -5.776744045786353 | [54,42] | [0,0,0] | -9 | hSpCas9 | negative selection | 5179859 | 127886472 | 127886494 | 4 | - | 27760321 | HT29 | viability after 16 days | TACGAAGGTATCGAGAATGTGG | PLK4 | ENSG00000142731 | -2.0233186283511357 | [83,65] | [39,11,11] | -8 | hSpCas9 | negative selection | 5179860 | 127885755 | 127885777 | 4 | + | 27760321 | HT29 | viability after 13 days | TCTCATGGTATACTACACCGGG | PLK4 | ENSG00000142731 | -6.649142332881742 | [96,75] | [0,0,0] | -9 | hSpCas9 | negative selection | 5263319 | 127885793 | 127885815 | 4 | - | 27760321 | HT29 | viability after 13 days | CATATTACGAGTCAGTAGGAGG | PLK4 | ENSG00000142731 | -6.10840177183136 | [274,214] | [0,0,9] | -9 | hSpCas9 | negative selection | 5263320 | 127885995 | 127886017 | 4 | - | 27760321 | HT29 | viability after 13 days | CTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -3.332965347289787 | [471,368] | [79,30,34] | -9 | hSpCas9 | negative selection | 5263321 | 127886090 | 127886112 | 4 | - | 27760321 | HT29 | viability after 13 days | ACGAAGTAACTGGTGAATAAGG | PLK4 | ENSG00000142731 | -5.829031445230491 | [54,42] | [0,0,0] | -9 | hSpCas9 | negative selection | 5263322 | 127886472 | 127886494 | 4 | - | 27760321 | HT29 | viability after 13 days | TACGAAGGTATCGAGAATGTGG | PLK4 | ENSG00000142731 | -1.357620559158315 | [83,65] | [40,28,31] | -8 | hSpCas9 | negative selection | 5263323 | 127885755 | 127885777 | 4 | + | 27760321 | HT29 | viability after 10 days | TCTCATGGTATACTACACCGGG | PLK4 | ENSG00000142731 | -3.2437757095598094 | [96,75] | [2,30,0] | -9 | hSpCas9 | negative selection | 5346782 | 127885793 | 127885815 | 4 | - | 27760321 | HT29 | viability after 10 days | CATATTACGAGTCAGTAGGAGG | PLK4 | ENSG00000142731 | -4.048206210013476 | [274,214] | [31,22,0] | -9 | hSpCas9 | negative selection | 5346783 | 127885995 | 127886017 | 4 | - | 27760321 | HT29 | viability after 10 days | CTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -2.207458484914637 | [471,368] | [155,113,71] | -9 | hSpCas9 | negative selection | 5346784 | 127886090 | 127886112 | 4 | - | 27760321 | HT29 | viability after 10 days | ACGAAGTAACTGGTGAATAAGG | PLK4 | ENSG00000142731 | -1.6370326607343468 | [54,42] | [15,0,40] | -8 | hSpCas9 | negative selection | 5346785 | 127886472 | 127886494 | 4 | - | 27760321 | HT29 | viability after 10 days | TACGAAGGTATCGAGAATGTGG | PLK4 | ENSG00000142731 | -3.5166831331666297 | [83,65] | [3,18,1] | -9 | hSpCas9 | negative selection | 5346786 | 127885755 | 127885777 | 4 | + | 27760321 | MOLM13 | viability | TCTCATGGTATACTACACCGGG | PLK4 | ENSG00000142731 | -5.871467535755837 | [110,96] | [0,0] | -9 | hSpCas9 | negative selection | 5430245 | 127885793 | 127885815 | 4 | - | 27760321 | MOLM13 | viability | CATATTACGAGTCAGTAGGAGG | PLK4 | ENSG00000142731 | -2.7637112793305514 | [302,274] | [50,0] | -8 | hSpCas9 | negative selection | 5430246 | 127885995 | 127886017 | 4 | - | 27760321 | MOLM13 | viability | CTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -1.5070538898791592 | [492,471] | [96,94] | -7 | hSpCas9 | negative selection | 5430247 | 127886090 | 127886112 | 4 | - | 27760321 | MOLM13 | viability | ACGAAGTAACTGGTGAATAAGG | PLK4 | ENSG00000142731 | -1.9243533130635448 | [68,54] | [6,10] | -8 | hSpCas9 | negative selection | 5430248 | 127886472 | 127886494 | 4 | - | 27760321 | MOLM13 | viability | TACGAAGGTATCGAGAATGTGG | PLK4 | ENSG00000142731 | -0.5574208661755957 | [86,83] | [34,30] | -4 | hSpCas9 | negative selection | 5430249 | 127880940 | 127880963 | 4 | + | 27661255 | K562 | viability | GGAGCCCAGAGGCACCGCCCAGG | PLK4 | ENSG00000142731 | -0.9418342943470563 | [591,665] | [260,260] | -8 | dCas9-KRAB | negative selection | 5502620 | 127880972 | 127880995 | 4 | + | 27661255 | K562 | viability | GTGTCAGGGAGAACTTTCCGTGG | PLK4 | ENSG00000142731 | -1.0155283490367581 | [1397,1354] | [642,459] | -8 | dCas9-KRAB | negative selection | 5502621 | 127881097 | 127881120 | 4 | + | 27661255 | K562 | viability | GAAGCTAATCCGGAGAACCCAGG | PLK4 | ENSG00000142731 | -0.664582471225246 | [990,1270] | [669,479] | -8 | dCas9-KRAB | negative selection | 5502622 | 127887430 | 127887453 | 4 | - | 27260156 | BXPC3 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.3879008246558188 | [503] | [304,389,496,432] | -7 | hSpCas9 | negative selection | 5563306 | 127893515 | 127893538 | 4 | + | 27260156 | BXPC3 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.5163230159655476 | [215] | [106,222,101,204] | -8 | hSpCas9 | negative selection | 5563307 | 127887452 | 127887475 | 4 | + | 27260156 | BXPC3 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.9058259350855278 | [161] | [81,98,92,86] | -9 | hSpCas9 | negative selection | 5563308 | 127893588 | 127893611 | 4 | - | 27260156 | BXPC3 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.45513014631528415 | [1862] | [2410,2408,2892,3043] | 8 | hSpCas9 | negative selection | 5627557 | 127887394 | 127887417 | 4 | + | 27260156 | BXPC3 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | -0.03383040295401818 | [1069] | [834,1094,1000,1510] | 0 | hSpCas9 | negative selection | 5627558 | 127887461 | 127887484 | 4 | - | 27260156 | BXPC3 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.17002761229520424 | [324] | [359,291,196,355] | -4 | hSpCas9 | negative selection | 5627559 | 127887430 | 127887453 | 4 | - | 27260156 | A673 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.38084494192823176 | [503] | [544,379,427,519] | -7 | hSpCas9 | negative selection | 5684557 | 127893515 | 127893538 | 4 | + | 27260156 | A673 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.575834767259235 | [215] | [271,135,175,120] | -8 | hSpCas9 | negative selection | 5684558 | 127887452 | 127887475 | 4 | + | 27260156 | A673 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.4274791290014863 | [161] | [99,134,191,145] | -8 | hSpCas9 | negative selection | 5684559 | 127893588 | 127893611 | 4 | - | 27260156 | A673 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.4639765041356638 | [1862] | [3199,2904,3047,3207] | 9 | hSpCas9 | negative selection | 5748808 | 127887394 | 127887417 | 4 | + | 27260156 | A673 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.06689258689917565 | [1069] | [1410,1176,1358,1450] | 1 | hSpCas9 | negative selection | 5748809 | 127887461 | 127887484 | 4 | - | 27260156 | A673 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.19945753424547707 | [324] | [357,340,364,293] | -5 | hSpCas9 | negative selection | 5748810 | 127887430 | 127887453 | 4 | - | 27260156 | A375 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -1.2142909945795288 | [503] | [289,198,249,265] | -8 | hSpCas9 | negative selection | 5805808 | 127893515 | 127893538 | 4 | + | 27260156 | A375 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.9249089694375652 | [215] | [169,75,177,102] | -8 | hSpCas9 | negative selection | 5805809 | 127887452 | 127887475 | 4 | + | 27260156 | A375 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.7218193910561523 | [161] | [86,171,71,132] | -7 | hSpCas9 | negative selection | 5805810 | 127893588 | 127893611 | 4 | - | 27260156 | A375 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.7488834203736829 | [1862] | [3720,4098,4015,2926] | 9 | hSpCas9 | negative selection | 5870059 | 127887394 | 127887417 | 4 | + | 27260156 | A375 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.09065707399281742 | [1069] | [1226,1580,1563,1017] | 1 | hSpCas9 | negative selection | 5870060 | 127887461 | 127887484 | 4 | - | 27260156 | A375 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -1.0277215620566205 | [324] | [183,294,101,178] | -8 | hSpCas9 | negative selection | 5870061 | 127887430 | 127887453 | 4 | - | 27260156 | COLO741 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.6450585595586737 | [503] | [462,409,368] | -8 | hSpCas9 | negative selection | 5927059 | 127893515 | 127893538 | 4 | + | 27260156 | COLO741 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.20817461062570541 | [215] | [277,182,256] | -4 | hSpCas9 | negative selection | 5927060 | 127887452 | 127887475 | 4 | + | 27260156 | COLO741 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.8809994376323442 | [161] | [148,120,72] | -9 | hSpCas9 | negative selection | 5927061 | 127893588 | 127893611 | 4 | - | 27260156 | COLO741 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.43113765181562935 | [1862] | [3654,3016,3001] | 8 | hSpCas9 | negative selection | 5991310 | 127887394 | 127887417 | 4 | + | 27260156 | COLO741 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.02178000311452899 | [1069] | [1843,1280,1095] | 0 | hSpCas9 | negative selection | 5991311 | 127887461 | 127887484 | 4 | - | 27260156 | COLO741 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | 0.17008375759267635 | [324] | [504,532,372] | 3 | hSpCas9 | negative selection | 5991312 | 127887430 | 127887453 | 4 | - | 27260156 | CAL120 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.12265853100476028 | [503] | [691,456,595] | -2 | hSpCas9 | negative selection | 6048310 | 127893515 | 127893538 | 4 | + | 27260156 | CAL120 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.6534354361718646 | [215] | [275,114,137] | -7 | hSpCas9 | negative selection | 6048311 | 127887452 | 127887475 | 4 | + | 27260156 | CAL120 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.9993691535542708 | [161] | [88,71,138] | -8 | hSpCas9 | negative selection | 6048312 | 127893588 | 127893611 | 4 | - | 27260156 | CAL120 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.7215749063035701 | [1862] | [3727,3699,4020] | 9 | hSpCas9 | negative selection | 6112561 | 127887394 | 127887417 | 4 | + | 27260156 | CAL120 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.13938963446089958 | [1069] | [1774,1344,1327] | 2 | hSpCas9 | negative selection | 6112562 | 127887461 | 127887484 | 4 | - | 27260156 | CAL120 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.17845094780229354 | [324] | [489,248,352] | -3 | hSpCas9 | negative selection | 6112563 | 127887430 | 127887453 | 4 | - | 27260156 | CADOES1 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.6764470284113002 | [503] | [311,257,336,264] | -8 | hSpCas9 | negative selection | 6169561 | 127893515 | 127893538 | 4 | + | 27260156 | CADOES1 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.4964995626847477 | [215] | [126,237,83,119] | -7 | hSpCas9 | negative selection | 6169562 | 127887452 | 127887475 | 4 | + | 27260156 | CADOES1 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.324522553934776 | [161] | [34,140,172,132] | -5 | hSpCas9 | negative selection | 6169563 | 127893588 | 127893611 | 4 | - | 27260156 | CADOES1 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.745097169637184 | [1862] | [3108,2926,2578,3004] | 9 | hSpCas9 | negative selection | 6233812 | 127887394 | 127887417 | 4 | + | 27260156 | CADOES1 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.16639687804433012 | [1069] | [1164,1116,1021,1164] | 3 | hSpCas9 | negative selection | 6233813 | 127887461 | 127887484 | 4 | - | 27260156 | CADOES1 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.3679945111888562 | [324] | [244,175,222,294] | -6 | hSpCas9 | negative selection | 6233814 | 127887430 | 127887453 | 4 | - | 27260156 | EWS502 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.8439328414732432 | [503] | [201,282,328,393] | -8 | hSpCas9 | negative selection | 6290812 | 127893515 | 127893538 | 4 | + | 27260156 | EWS502 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.2931860105025672 | [215] | [209,158,243,127] | -5 | hSpCas9 | negative selection | 6290813 | 127887452 | 127887475 | 4 | + | 27260156 | EWS502 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -1.1917174326089106 | [161] | [112,80,35,63] | -9 | hSpCas9 | negative selection | 6290814 | 127893588 | 127893611 | 4 | - | 27260156 | EWS502 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.6371963485909975 | [1862] | [3076,3043,2996,3150] | 9 | hSpCas9 | negative selection | 6355063 | 127887394 | 127887417 | 4 | + | 27260156 | EWS502 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.25096793941400186 | [1069] | [1019,1273,1434,1731] | 4 | hSpCas9 | negative selection | 6355064 | 127887461 | 127887484 | 4 | - | 27260156 | EWS502 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.7145514481322308 | [324] | [131,280,221,209] | -8 | hSpCas9 | negative selection | 6355065 | 127887430 | 127887453 | 4 | - | 27260156 | EW8 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.5811334824490432 | [503] | [320,352,178,259] | -8 | hSpCas9 | negative selection | 6412063 | 127893515 | 127893538 | 4 | + | 27260156 | EW8 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.5009060225985926 | [215] | [127,160,88,122] | -7 | hSpCas9 | negative selection | 6412064 | 127887452 | 127887475 | 4 | + | 27260156 | EW8 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | 0.0585146747407117 | [161] | [275,179,37,84] | 1 | hSpCas9 | negative selection | 6412065 | 127893588 | 127893611 | 4 | - | 27260156 | EW8 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.646325708771547 | [1862] | [2319,2770,2067,2333] | 9 | hSpCas9 | negative selection | 6476314 | 127887394 | 127887417 | 4 | + | 27260156 | EW8 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.012082556913295628 | [1069] | [982,612,852,1059] | 0 | hSpCas9 | negative selection | 6476315 | 127887461 | 127887484 | 4 | - | 27260156 | EW8 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | 0.043851731304214325 | [324] | [361,284,256,193] | 0 | hSpCas9 | negative selection | 6476316 | 127887430 | 127887453 | 4 | - | 27260156 | CORL105 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.8541537780972691 | [503] | [236,266,507,319] | -9 | hSpCas9 | negative selection | 6533314 | 127893515 | 127893538 | 4 | + | 27260156 | CORL105 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.16894928237188034 | [215] | [263,245,244,148] | -3 | hSpCas9 | negative selection | 6533315 | 127887452 | 127887475 | 4 | + | 27260156 | CORL105 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -1.0719437244490373 | [161] | [132,73,116,42] | -9 | hSpCas9 | negative selection | 6533316 | 127893588 | 127893611 | 4 | - | 27260156 | CORL105 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.5341321087393582 | [1862] | [3000,2976,3773,2974] | 8 | hSpCas9 | negative selection | 6597565 | 127887394 | 127887417 | 4 | + | 27260156 | CORL105 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | -0.08306313620707573 | [1069] | [867,1154,1431,1302] | -1 | hSpCas9 | negative selection | 6597566 | 127887461 | 127887484 | 4 | - | 27260156 | CORL105 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.14885864376349478 | [324] | [466,227,454,246] | -3 | hSpCas9 | negative selection | 6597567 | 127887430 | 127887453 | 4 | - | 27260156 | HS294T | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -1.22963571532242 | [503] | [34,76,86,148] | -9 | hSpCas9 | negative selection | 6654565 | 127893515 | 127893538 | 4 | + | 27260156 | HS294T | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.2510970941595738 | [215] | [72,69,72,62] | -4 | hSpCas9 | negative selection | 6654566 | 127887452 | 127887475 | 4 | + | 27260156 | HS294T | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | 0.6675158323715138 | [161] | [85,104,126,76] | 8 | hSpCas9 | negative selection | 6654567 | 127893588 | 127893611 | 4 | - | 27260156 | HS294T | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.4697663857015766 | [1862] | [893,1087,758,1303] | 6 | hSpCas9 | negative selection | 6718816 | 127887394 | 127887417 | 4 | + | 27260156 | HS294T | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | -0.1652814142087966 | [1069] | [244,361,494,387] | -2 | hSpCas9 | negative selection | 6718817 | 127887461 | 127887484 | 4 | - | 27260156 | HS294T | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | 0.41035318417031896 | [324] | [329,100,79,137] | 5 | hSpCas9 | negative selection | 6718818 | 127887430 | 127887453 | 4 | - | 27260156 | HCC44 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.2716364831348478 | [503] | [553,349,402,586] | -4 | hSpCas9 | negative selection | 6775816 | 127893515 | 127893538 | 4 | + | 27260156 | HCC44 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.30679770321934274 | [215] | [178,201,183,217] | -5 | hSpCas9 | negative selection | 6775817 | 127887452 | 127887475 | 4 | + | 27260156 | HCC44 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.030032189959920075 | [161] | [178,184,205,150] | 0 | hSpCas9 | negative selection | 6775818 | 127893588 | 127893611 | 4 | - | 27260156 | HCC44 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.5017790294052256 | [1862] | [3120,3097,3040,2665] | 8 | hSpCas9 | negative selection | 6840067 | 127887394 | 127887417 | 4 | + | 27260156 | HCC44 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.435060770232091 | [1069] | [1821,1433,2116,1297] | 7 | hSpCas9 | negative selection | 6840068 | 127887461 | 127887484 | 4 | - | 27260156 | HCC44 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | 0.42852017048227625 | [324] | [463,394,686,473] | 7 | hSpCas9 | negative selection | 6840069 | 127887430 | 127887453 | 4 | - | 27260156 | G402 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.007356216239505997 | [503] | [1269,331,652,284] | 0 | hSpCas9 | negative selection | 6897067 | 127893515 | 127893538 | 4 | + | 27260156 | G402 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.8037746779083033 | [215] | [179,162,66,195] | -7 | hSpCas9 | negative selection | 6897068 | 127887452 | 127887475 | 4 | + | 27260156 | G402 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.7534045836808283 | [161] | [157,62,189,62] | -7 | hSpCas9 | negative selection | 6897069 | 127893588 | 127893611 | 4 | - | 27260156 | G402 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.9445039603171292 | [1862] | [5302,3876,3763,4630] | 9 | hSpCas9 | negative selection | 6961318 | 127887394 | 127887417 | 4 | + | 27260156 | G402 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.1420885002326555 | [1069] | [2228,967,1168,1475] | 1 | hSpCas9 | negative selection | 6961319 | 127887461 | 127887484 | 4 | - | 27260156 | G402 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | 0.019577506564818603 | [324] | [416,738,236,242] | 0 | hSpCas9 | negative selection | 6961320 | 127887430 | 127887453 | 4 | - | 27260156 | L33 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.25226505679056116 | [503] | [390,183,265,429] | -5 | hSpCas9 | negative selection | 7018318 | 127893515 | 127893538 | 4 | + | 27260156 | L33 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | 0.23120386944756022 | [215] | [323,84,132,268] | 5 | hSpCas9 | negative selection | 7018319 | 127887452 | 127887475 | 4 | + | 27260156 | L33 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.7422047177125615 | [161] | [91,33,57,119] | -9 | hSpCas9 | negative selection | 7018320 | 127893588 | 127893611 | 4 | - | 27260156 | L33 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.2861389213289811 | [1862] | [2218,863,1371,2573] | 6 | hSpCas9 | negative selection | 7082569 | 127887394 | 127887417 | 4 | + | 27260156 | L33 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.10651632243106146 | [1069] | [1241,450,736,1090] | 2 | hSpCas9 | negative selection | 7082570 | 127887461 | 127887484 | 4 | - | 27260156 | L33 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | 0.1712073661914431 | [324] | [390,138,294,264] | 4 | hSpCas9 | negative selection | 7082571 | 127887430 | 127887453 | 4 | - | 27260156 | K562 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.12357418642827879 | [503] | [302,326,914,389] | 1 | hSpCas9 | negative selection | 7139569 | 127893515 | 127893538 | 4 | + | 27260156 | K562 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.2698301408492638 | [215] | [129,213,115,173] | -3 | hSpCas9 | negative selection | 7139570 | 127887452 | 127887475 | 4 | + | 27260156 | K562 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.6827036264454254 | [161] | [63,46,194,51] | -7 | hSpCas9 | negative selection | 7139571 | 127893588 | 127893611 | 4 | - | 27260156 | K562 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.7367529001037962 | [1862] | [2816,3231,2483,2531] | 8 | hSpCas9 | negative selection | 7203820 | 127887394 | 127887417 | 4 | + | 27260156 | K562 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.6314638225756419 | [1069] | [1149,1539,2014,1183] | 7 | hSpCas9 | negative selection | 7203821 | 127887461 | 127887484 | 4 | - | 27260156 | K562 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.228956390680223 | [324] | [345,258,214,179] | -3 | hSpCas9 | negative selection | 7203822 | 127887430 | 127887453 | 4 | - | 27260156 | HT29 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.48511727207896266 | [503] | [313,483,585,366] | -7 | hSpCas9 | negative selection | 7260820 | 127893515 | 127893538 | 4 | + | 27260156 | HT29 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.880953306917672 | [215] | [124,236,142,78] | -8 | hSpCas9 | negative selection | 7260821 | 127887452 | 127887475 | 4 | + | 27260156 | HT29 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.889807164772435 | [161] | [75,176,85,90] | -8 | hSpCas9 | negative selection | 7260822 | 127893588 | 127893611 | 4 | - | 27260156 | HT29 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.5292524517801585 | [1862] | [3937,3388,3185,2672] | 8 | hSpCas9 | negative selection | 7325071 | 127887394 | 127887417 | 4 | + | 27260156 | HT29 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.008346789057754656 | [1069] | [1529,1295,1208,1215] | 0 | hSpCas9 | negative selection | 7325072 | 127887461 | 127887484 | 4 | - | 27260156 | HT29 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.40233525533505077 | [324] | [399,258,303,241] | -6 | hSpCas9 | negative selection | 7325073 | 127887430 | 127887453 | 4 | - | 27260156 | MHHES1 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.5828239382142387 | [503] | [562,516,378,140] | -8 | hSpCas9 | negative selection | 7382071 | 127893515 | 127893538 | 4 | + | 27260156 | MHHES1 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.699439859813477 | [215] | [244,196,58,117] | -8 | hSpCas9 | negative selection | 7382072 | 127887452 | 127887475 | 4 | + | 27260156 | MHHES1 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.1991879658236526 | [161] | [222,166,206,65] | -4 | hSpCas9 | negative selection | 7382073 | 127893588 | 127893611 | 4 | - | 27260156 | MHHES1 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.5720842737165366 | [1862] | [3584,3944,2911,2296] | 8 | hSpCas9 | negative selection | 7446322 | 127887394 | 127887417 | 4 | + | 27260156 | MHHES1 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | -0.010574381107574471 | [1069] | [1386,1444,1038,983] | 0 | hSpCas9 | negative selection | 7446323 | 127887461 | 127887484 | 4 | - | 27260156 | MHHES1 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.39382093098548354 | [324] | [215,380,333,198] | -6 | hSpCas9 | negative selection | 7446324 | 127887430 | 127887453 | 4 | - | 27260156 | MEWO | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.5115170662827048 | [503] | [334,339,317] | -8 | hSpCas9 | negative selection | 7503322 | 127893515 | 127893538 | 4 | + | 27260156 | MEWO | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.18204828073394919 | [215] | [155,187,185] | -4 | hSpCas9 | negative selection | 7503323 | 127887452 | 127887475 | 4 | + | 27260156 | MEWO | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.3929547542054952 | [161] | [58,179,95] | -7 | hSpCas9 | negative selection | 7503324 | 127893588 | 127893611 | 4 | - | 27260156 | MEWO | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.3196492571774032 | [1862] | [2813,1768,2067] | 6 | hSpCas9 | negative selection | 7567573 | 127887394 | 127887417 | 4 | + | 27260156 | MEWO | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.1482381782895832 | [1069] | [1381,1049,948] | 3 | hSpCas9 | negative selection | 7567574 | 127887461 | 127887484 | 4 | - | 27260156 | MEWO | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | 0.017294654174766166 | [324] | [505,208,246] | 0 | hSpCas9 | negative selection | 7567575 | 127887430 | 127887453 | 4 | - | 27260156 | LNCAPCLONEFGC | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -1.3222446403238615 | [503] | [76,167,261,237] | -9 | hSpCas9 | negative selection | 7624573 | 127893515 | 127893538 | 4 | + | 27260156 | LNCAPCLONEFGC | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.28380962974751545 | [215] | [141,85,240,190] | -4 | hSpCas9 | negative selection | 7624574 | 127887452 | 127887475 | 4 | + | 27260156 | LNCAPCLONEFGC | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -1.1111980913109716 | [161] | [27,69,85,90] | -9 | hSpCas9 | negative selection | 7624575 | 127893588 | 127893611 | 4 | - | 27260156 | LNCAPCLONEFGC | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.7417468496698236 | [1862] | [2331,2773,3314,2950] | 9 | hSpCas9 | negative selection | 7688824 | 127887394 | 127887417 | 4 | + | 27260156 | LNCAPCLONEFGC | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.20766612653043315 | [1069] | [1036,919,1534,1060] | 3 | hSpCas9 | negative selection | 7688825 | 127887461 | 127887484 | 4 | - | 27260156 | LNCAPCLONEFGC | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.46387520540860394 | [324] | [172,198,176,300] | -6 | hSpCas9 | negative selection | 7688826 | 127887430 | 127887453 | 4 | - | 27260156 | PANC0327 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.47057598998119887 | [503] | [350,342,300,296] | -6 | hSpCas9 | negative selection | 7745824 | 127893515 | 127893538 | 4 | + | 27260156 | PANC0327 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -1.0628863862233775 | [215] | [161,107,59,40] | -8 | hSpCas9 | negative selection | 7745825 | 127887452 | 127887475 | 4 | + | 27260156 | PANC0327 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.5472908781968515 | [161] | [40,44,103,205] | -7 | hSpCas9 | negative selection | 7745826 | 127893588 | 127893611 | 4 | - | 27260156 | PANC0327 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.39651293886060457 | [1862] | [2247,2265,2401,1791] | 6 | hSpCas9 | negative selection | 7810075 | 127887394 | 127887417 | 4 | + | 27260156 | PANC0327 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.0692232612579482 | [1069] | [1848,649,803,799] | 1 | hSpCas9 | negative selection | 7810076 | 127887461 | 127887484 | 4 | - | 27260156 | PANC0327 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | 0.0764533747223215 | [324] | [155,421,217,393] | 1 | hSpCas9 | negative selection | 7810077 | 127887430 | 127887453 | 4 | - | 27260156 | NCIH2009 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.7595032111393243 | [503] | [505,412,345] | -7 | hSpCas9 | negative selection | 7867075 | 127893515 | 127893538 | 4 | + | 27260156 | NCIH2009 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.8563313994692325 | [215] | [188,177,136] | -8 | hSpCas9 | negative selection | 7867076 | 127887452 | 127887475 | 4 | + | 27260156 | NCIH2009 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.8309395683372323 | [161] | [97,111,165] | -7 | hSpCas9 | negative selection | 7867077 | 127893588 | 127893611 | 4 | - | 27260156 | NCIH2009 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.4537532653511611 | [1862] | [4245,2978,3608] | 6 | hSpCas9 | negative selection | 7931326 | 127887394 | 127887417 | 4 | + | 27260156 | NCIH2009 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.084744167677274 | [1069] | [2477,1361,1093] | 1 | hSpCas9 | negative selection | 7931327 | 127887461 | 127887484 | 4 | - | 27260156 | NCIH2009 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.6890079811372822 | [324] | [452,245,179] | -7 | hSpCas9 | negative selection | 7931328 | 127887430 | 127887453 | 4 | - | 27260156 | NCIH1373 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.9085520000863654 | [503] | [318,261,193,116] | -7 | hSpCas9 | negative selection | 7988326 | 127893515 | 127893538 | 4 | + | 27260156 | NCIH1373 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.22427885810451276 | [215] | [276,170,213,46] | -2 | hSpCas9 | negative selection | 7988327 | 127887452 | 127887475 | 4 | + | 27260156 | NCIH1373 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.6157630423650411 | [161] | [164,105,159,11] | -6 | hSpCas9 | negative selection | 7988328 | 127893588 | 127893611 | 4 | - | 27260156 | NCIH1373 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.9768944951923542 | [1862] | [4513,3063,4578,1168] | 8 | hSpCas9 | negative selection | 8052577 | 127887394 | 127887417 | 4 | + | 27260156 | NCIH1373 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | -0.09326993001496575 | [1069] | [1020,883,1220,364] | -1 | hSpCas9 | negative selection | 8052578 | 127887461 | 127887484 | 4 | - | 27260156 | NCIH1373 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.10236678587726444 | [324] | [568,236,360,59] | -1 | hSpCas9 | negative selection | 8052579 | 127887430 | 127887453 | 4 | - | 27260156 | PATU8902 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.9403379743680087 | [503] | [286,502,192,544] | -7 | hSpCas9 | negative selection | 8109577 | 127893515 | 127893538 | 4 | + | 27260156 | PATU8902 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -2.020074792459402 | [215] | [30,36,44,206] | -9 | hSpCas9 | negative selection | 8109578 | 127887452 | 127887475 | 4 | + | 27260156 | PATU8902 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.8865979994048345 | [161] | [11,327,50,115] | -7 | hSpCas9 | negative selection | 8109579 | 127893588 | 127893611 | 4 | - | 27260156 | PATU8902 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.8666998950317655 | [1862] | [4493,4443,4142,6127] | 8 | hSpCas9 | negative selection | 8173828 | 127887394 | 127887417 | 4 | + | 27260156 | PATU8902 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | -0.24425373956880092 | [1069] | [920,1258,1400,1428] | -2 | hSpCas9 | negative selection | 8173829 | 127887461 | 127887484 | 4 | - | 27260156 | PATU8902 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.912854899586556 | [324] | [226,170,111,515] | -7 | hSpCas9 | negative selection | 8173830 | 127887430 | 127887453 | 4 | - | 27260156 | PANC1 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.8292049651999837 | [503] | [172,332,343,155] | -8 | hSpCas9 | negative selection | 8230828 | 127893515 | 127893538 | 4 | + | 27260156 | PANC1 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -1.6477536632469314 | [215] | [49,41,109,34] | -9 | hSpCas9 | negative selection | 8230829 | 127887452 | 127887475 | 4 | + | 27260156 | PANC1 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -1.3133827621809124 | [161] | [16,86,67,57] | -9 | hSpCas9 | negative selection | 8230830 | 127893588 | 127893611 | 4 | - | 27260156 | PANC1 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.6590157297772234 | [1862] | [2597,2569,2659,2284] | 9 | hSpCas9 | negative selection | 8295079 | 127887394 | 127887417 | 4 | + | 27260156 | PANC1 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.165811315210167 | [1069] | [1195,1205,986,789] | 2 | hSpCas9 | negative selection | 8295080 | 127887461 | 127887484 | 4 | - | 27260156 | PANC1 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.31852453886609644 | [324] | [317,155,228,179] | -5 | hSpCas9 | negative selection | 8295081 | 127887430 | 127887453 | 4 | - | 27260156 | PANC0813 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -1.0161730046012343 | [503] | [423,223,270,264] | -8 | hSpCas9 | negative selection | 8352079 | 127893515 | 127893538 | 4 | + | 27260156 | PANC0813 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.3622996339819904 | [215] | [237,295,142,119] | -5 | hSpCas9 | negative selection | 8352080 | 127887452 | 127887475 | 4 | + | 27260156 | PANC0813 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.35148372355438573 | [161] | [86,128,88,277] | -5 | hSpCas9 | negative selection | 8352081 | 127893588 | 127893611 | 4 | - | 27260156 | PANC0813 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.35228023029477895 | [1862] | [2963,3012,2540,2672] | 5 | hSpCas9 | negative selection | 8416330 | 127887394 | 127887417 | 4 | + | 27260156 | PANC0813 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | -0.3737912834108188 | [1069] | [988,1107,910,876] | -5 | hSpCas9 | negative selection | 8416331 | 127887461 | 127887484 | 4 | - | 27260156 | PANC0813 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.5983089470573086 | [324] | [252,324,127,298] | -7 | hSpCas9 | negative selection | 8416332 | 127887430 | 127887453 | 4 | - | 27260156 | RDES | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.6438271798108407 | [503] | [288,434,326,441] | -8 | hSpCas9 | negative selection | 8473330 | 127893515 | 127893538 | 4 | + | 27260156 | RDES | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.3755445026818516 | [215] | [143,164,227,245] | -6 | hSpCas9 | negative selection | 8473331 | 127887452 | 127887475 | 4 | + | 27260156 | RDES | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.6619528352078925 | [161] | [99,123,98,151] | -8 | hSpCas9 | negative selection | 8473332 | 127893588 | 127893611 | 4 | - | 27260156 | RDES | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.7344331446914338 | [1862] | [2690,3212,4346,4263] | 9 | hSpCas9 | negative selection | 8537581 | 127887394 | 127887417 | 4 | + | 27260156 | RDES | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.2847040768790048 | [1069] | [1302,1300,1781,1659] | 4 | hSpCas9 | negative selection | 8537582 | 127887461 | 127887484 | 4 | - | 27260156 | RDES | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.22877224567404775 | [324] | [252,251,314,493] | -4 | hSpCas9 | negative selection | 8537583 | 127887430 | 127887453 | 4 | - | 27260156 | PC3 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.3580612989713734 | [503] | [118,389,697,587] | -7 | hSpCas9 | negative selection | 8594581 | 127893515 | 127893538 | 4 | + | 27260156 | PC3 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | 0.02765097364153979 | [215] | [124,267,419,158] | 0 | hSpCas9 | negative selection | 8594582 | 127887452 | 127887475 | 4 | + | 27260156 | PC3 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.45762706741004844 | [161] | [68,86,227,142] | -8 | hSpCas9 | negative selection | 8594583 | 127893588 | 127893611 | 4 | - | 27260156 | PC3 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.40470121244883406 | [1862] | [1535,2398,3774,2819] | 8 | hSpCas9 | negative selection | 8658832 | 127887394 | 127887417 | 4 | + | 27260156 | PC3 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.3138983156326558 | [1069] | [906,979,2542,1417] | 6 | hSpCas9 | negative selection | 8658833 | 127887461 | 127887484 | 4 | - | 27260156 | PC3 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | 0.16335188019673197 | [324] | [200,397,502,443] | 3 | hSpCas9 | negative selection | 8658834 | 127887430 | 127887453 | 4 | - | 27260156 | PATU8988T | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.4109626321341013 | [503] | [372,391,247,463] | -6 | hSpCas9 | negative selection | 8715832 | 127893515 | 127893538 | 4 | + | 27260156 | PATU8988T | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -1.3105261999784221 | [215] | [91,92,103,44] | -9 | hSpCas9 | negative selection | 8715833 | 127887452 | 127887475 | 4 | + | 27260156 | PATU8988T | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.27426891515562657 | [161] | [220,95,131,59] | -4 | hSpCas9 | negative selection | 8715834 | 127893588 | 127893611 | 4 | - | 27260156 | PATU8988T | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.626424179863666 | [1862] | [2710,2751,2614,3059] | 8 | hSpCas9 | negative selection | 8780083 | 127887394 | 127887417 | 4 | + | 27260156 | PATU8988T | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.13545354849704028 | [1069] | [1393,1220,1031,884] | 2 | hSpCas9 | negative selection | 8780084 | 127887461 | 127887484 | 4 | - | 27260156 | PATU8988T | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.020012820829096167 | [324] | [154,301,252,547] | 0 | hSpCas9 | negative selection | 8780085 | 127887430 | 127887453 | 4 | - | 27260156 | T47D | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.36059324867599263 | [503] | [348,475,453,550] | -6 | hSpCas9 | negative selection | 8837083 | 127893515 | 127893538 | 4 | + | 27260156 | T47D | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.010230739574026204 | [215] | [285,240,257,213] | 0 | hSpCas9 | negative selection | 8837084 | 127887452 | 127887475 | 4 | + | 27260156 | T47D | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.6194268584051601 | [161] | [126,141,99,120] | -8 | hSpCas9 | negative selection | 8837085 | 127893588 | 127893611 | 4 | - | 27260156 | T47D | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.5107938191608714 | [1862] | [3022,2878,3067,3427] | 9 | hSpCas9 | negative selection | 8901334 | 127887394 | 127887417 | 4 | + | 27260156 | T47D | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.3251377136144691 | [1069] | [1616,1482,1603,1547] | 7 | hSpCas9 | negative selection | 8901335 | 127887461 | 127887484 | 4 | - | 27260156 | T47D | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.3156662990374093 | [324] | [286,301,273,355] | -6 | hSpCas9 | negative selection | 8901336 | 127887430 | 127887453 | 4 | - | 27260156 | SU8686 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.38978502348432 | [503] | [304,259,566,427] | -6 | hSpCas9 | negative selection | 8958334 | 127893515 | 127893538 | 4 | + | 27260156 | SU8686 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.9268129623821557 | [215] | [97,157,115,65] | -8 | hSpCas9 | negative selection | 8958335 | 127887452 | 127887475 | 4 | + | 27260156 | SU8686 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.5922809687548782 | [161] | [124,81,122,94] | -7 | hSpCas9 | negative selection | 8958336 | 127893588 | 127893611 | 4 | - | 27260156 | SU8686 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.5556419279107987 | [1862] | [2288,2355,2915,3507] | 8 | hSpCas9 | negative selection | 9022585 | 127887394 | 127887417 | 4 | + | 27260156 | SU8686 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | -0.004752940435407194 | [1069] | [1043,958,986,1279] | 0 | hSpCas9 | negative selection | 9022586 | 127887461 | 127887484 | 4 | - | 27260156 | SU8686 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.6458795404410291 | [324] | [224,145,202,262] | -7 | hSpCas9 | negative selection | 9022587 | 127887430 | 127887453 | 4 | - | 27260156 | SKES1 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.7676288765634293 | [503] | [345,329,381,147] | -9 | hSpCas9 | negative selection | 9079585 | 127893515 | 127893538 | 4 | + | 27260156 | SKES1 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.4328827486630331 | [215] | [112,262,144,125] | -7 | hSpCas9 | negative selection | 9079586 | 127887452 | 127887475 | 4 | + | 27260156 | SKES1 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.8809361234484836 | [161] | [64,94,134,55] | -9 | hSpCas9 | negative selection | 9079587 | 127893588 | 127893611 | 4 | - | 27260156 | SKES1 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.5270989397500732 | [1862] | [2938,2932,2552,2364] | 9 | hSpCas9 | negative selection | 9143836 | 127887394 | 127887417 | 4 | + | 27260156 | SKES1 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.21051489855333294 | [1069] | [1434,1224,1238,1073] | 4 | hSpCas9 | negative selection | 9143837 | 127887461 | 127887484 | 4 | - | 27260156 | SKES1 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.09675121953519994 | [324] | [300,336,213,355] | -2 | hSpCas9 | negative selection | 9143838 | 127887430 | 127887453 | 4 | - | 27260156 | TOV112D | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.4115380930877091 | [503] | [272,535,396,341] | -7 | hSpCas9 | negative selection | 9200836 | 127893515 | 127893538 | 4 | + | 27260156 | TOV112D | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | 0.12788458297236938 | [215] | [449,133,191,163] | 2 | hSpCas9 | negative selection | 9200837 | 127887452 | 127887475 | 4 | + | 27260156 | TOV112D | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.2085605149213381 | [161] | [111,221,100,143] | -4 | hSpCas9 | negative selection | 9200838 | 127893588 | 127893611 | 4 | - | 27260156 | TOV112D | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.5148623535257724 | [1862] | [2719,3263,2392,2440] | 8 | hSpCas9 | negative selection | 9265087 | 127887394 | 127887417 | 4 | + | 27260156 | TOV112D | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.1714538457953192 | [1069] | [1454,1483,925,1053] | 3 | hSpCas9 | negative selection | 9265088 | 127887461 | 127887484 | 4 | - | 27260156 | TOV112D | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.014621447964203949 | [324] | [284,507,362,178] | 0 | hSpCas9 | negative selection | 9265089 | 127887430 | 127887453 | 4 | - | 27260156 | TC71 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.2667621709799722 | [503] | [503,439,536,301] | -6 | hSpCas9 | negative selection | 9322087 | 127893515 | 127893538 | 4 | + | 27260156 | TC71 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.07308162968094534 | [215] | [170,225,223,262] | -2 | hSpCas9 | negative selection | 9322088 | 127887452 | 127887475 | 4 | + | 27260156 | TC71 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.5302051244686004 | [161] | [114,177,96,89] | -9 | hSpCas9 | negative selection | 9322089 | 127893588 | 127893611 | 4 | - | 27260156 | TC71 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.4843601181202215 | [1862] | [2925,2540,2689,3032] | 9 | hSpCas9 | negative selection | 9386338 | 127887394 | 127887417 | 4 | + | 27260156 | TC71 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.15662410302658292 | [1069] | [1048,1382,1313,1377] | 4 | hSpCas9 | negative selection | 9386339 | 127887461 | 127887484 | 4 | - | 27260156 | TC71 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | 0.011198694490564765 | [324] | [422,325,306,347] | 0 | hSpCas9 | negative selection | 9386340 | 127887430 | 127887453 | 4 | - | 27260156 | TC32 | viability | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.7010776457966686 | [503] | [233,221,423,326] | -8 | hSpCas9 | negative selection | 9443338 | 127893515 | 127893538 | 4 | + | 27260156 | TC32 | viability | TCATCGTATTTGTTTAGCACTGG | PLK4 | ENSG00000142731 | -0.6166325788192 | [215] | [156,71,184,136] | -8 | hSpCas9 | negative selection | 9443339 | 127887452 | 127887475 | 4 | + | 27260156 | TC32 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.8191962447628285 | [161] | [69,65,107,110] | -9 | hSpCas9 | negative selection | 9443340 | 127893588 | 127893611 | 4 | - | 27260156 | TC32 | viability | ATTTACCTTCCTATGATTATTGG | PLK4 | ENSG00000142731 | 0.7047424164136762 | [1862] | [2989,1773,3727,3325] | 9 | hSpCas9 | negative selection | 9507589 | 127887394 | 127887417 | 4 | + | 27260156 | TC32 | viability | AGCTCCAATCATCTTTGTCCAGG | PLK4 | ENSG00000142731 | 0.26868550431950244 | [1069] | [1172,1081,1392,1204] | 5 | hSpCas9 | negative selection | 9507590 | 127887461 | 127887484 | 4 | - | 27260156 | TC32 | viability | ATTCCCAAACCACTGTTGTACGG | PLK4 | ENSG00000142731 | -0.025995991003164742 | [324] | [337,132,403,389] | 0 | hSpCas9 | negative selection | 9507591 | 127885914 | 127885937 | 4 | + | 27869803 | HPAFII | viability after 27 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | -1.1017067725925418 | [94] | [49,0,NaN] | -6 | hSpCas9 | negative selection | 9586883 | 127885998 | 127886021 | 4 | - | 27869803 | HPAFII | viability after 27 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | -0.12897904595968113 | [654] | [267,353,NaN] | -1 | hSpCas9 | negative selection | 9586884 | 127887430 | 127887453 | 4 | - | 27869803 | HPAFII | viability after 27 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.19465453653205222 | [615] | [356,381,NaN] | 1 | hSpCas9 | negative selection | 9586885 | 127891615 | 127891638 | 4 | - | 27869803 | HPAFII | viability after 27 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -0.23996189575561477 | [164] | [73,72,NaN] | -2 | hSpCas9 | negative selection | 9586886 | 127893839 | 127893862 | 4 | + | 27869803 | HPAFII | viability after 27 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | 1.014654426277518 | [376] | [628,209,NaN] | 8 | hSpCas9 | negative selection | 9586887 | 127895072 | 127895095 | 4 | + | 27869803 | HPAFII | viability after 27 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | -0.20647164418530217 | [166] | [86,66,NaN] | -1 | hSpCas9 | negative selection | 9586888 | 127885914 | 127885937 | 4 | + | 27869803 | HPAFII | viability after 15 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | -0.19178093629035353 | [94] | [163,42,NaN] | -2 | hSpCas9 | negative selection | 9669332 | 127885998 | 127886021 | 4 | - | 27869803 | HPAFII | viability after 15 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | -0.09673483426123308 | [654] | [780,581,NaN] | -1 | hSpCas9 | negative selection | 9669333 | 127887430 | 127887453 | 4 | - | 27869803 | HPAFII | viability after 15 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.49170403873410073 | [615] | [1335,678,NaN] | 5 | hSpCas9 | negative selection | 9669334 | 127891615 | 127891638 | 4 | - | 27869803 | HPAFII | viability after 15 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -0.1863655663178625 | [164] | [235,105,NaN] | -2 | hSpCas9 | negative selection | 9669335 | 127893839 | 127893862 | 4 | + | 27869803 | HPAFII | viability after 15 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | 0.12232076471524655 | [376] | [699,279,NaN] | 1 | hSpCas9 | negative selection | 9669336 | 127895072 | 127895095 | 4 | + | 27869803 | HPAFII | viability after 15 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | -0.049165884329473 | [166] | [170,174,NaN] | 0 | hSpCas9 | negative selection | 9669337 | 127885914 | 127885937 | 4 | + | 27869803 | ASPC1 | viability after 36 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | -0.0669262847055988 | [332] | [277,44,44] | 0 | hSpCas9 | negative selection | 9751781 | 127885998 | 127886021 | 4 | - | 27869803 | ASPC1 | viability after 36 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | 0.6412910967265022 | [1543] | [784,1172,606] | 6 | hSpCas9 | negative selection | 9751782 | 127887430 | 127887453 | 4 | - | 27869803 | ASPC1 | viability after 36 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.1473235334558003 | [1508] | [827,786,243] | 1 | hSpCas9 | negative selection | 9751783 | 127891615 | 127891638 | 4 | - | 27869803 | ASPC1 | viability after 36 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | 0.9489989625286339 | [443] | [89,167,546] | 8 | hSpCas9 | negative selection | 9751784 | 127893839 | 127893862 | 4 | + | 27869803 | ASPC1 | viability after 36 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | -0.5177928197135411 | [1019] | [150,387,203] | -5 | hSpCas9 | negative selection | 9751785 | 127895072 | 127895095 | 4 | + | 27869803 | ASPC1 | viability after 36 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | 0.43403740027048665 | [428] | [212,177,211] | 4 | hSpCas9 | negative selection | 9751786 | 127885914 | 127885937 | 4 | + | 27869803 | PATU8988S | viability after 35 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | -0.019109574152680553 | [286] | [143,83,NaN] | 0 | hSpCas9 | negative selection | 9834230 | 127885998 | 127886021 | 4 | - | 27869803 | PATU8988S | viability after 35 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | -0.20465987950708175 | [1428] | [460,537,NaN] | -2 | hSpCas9 | negative selection | 9834231 | 127887430 | 127887453 | 4 | - | 27869803 | PATU8988S | viability after 35 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.19081919069606235 | [1279] | [517,384,NaN] | -2 | hSpCas9 | negative selection | 9834232 | 127891615 | 127891638 | 4 | - | 27869803 | PATU8988S | viability after 35 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -2.6376100776941316 | [385] | [16,32,NaN] | -9 | hSpCas9 | negative selection | 9834233 | 127893839 | 127893862 | 4 | + | 27869803 | PATU8988S | viability after 35 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | -0.27221286477808393 | [831] | [263,290,NaN] | -3 | hSpCas9 | negative selection | 9834234 | 127895072 | 127895095 | 4 | + | 27869803 | PATU8988S | viability after 35 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | -1.377605375534039 | [460] | [51,90,NaN] | -8 | hSpCas9 | negative selection | 9834235 | 127885914 | 127885937 | 4 | + | 27869803 | PATU8988S | viability after 31 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | -0.8483389881046371 | [286] | [74,48,NaN] | -7 | hSpCas9 | negative selection | 9916679 | 127885998 | 127886021 | 4 | - | 27869803 | PATU8988S | viability after 31 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | -0.09884995903628058 | [1428] | [484,591,NaN] | -1 | hSpCas9 | negative selection | 9916680 | 127887430 | 127887453 | 4 | - | 27869803 | PATU8988S | viability after 31 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | -0.08955888710468907 | [1279] | [436,533,NaN] | -1 | hSpCas9 | negative selection | 9916681 | 127891615 | 127891638 | 4 | - | 27869803 | PATU8988S | viability after 31 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -1.8613406267771684 | [385] | [44,38,NaN] | -9 | hSpCas9 | negative selection | 9916682 | 127893839 | 127893862 | 4 | + | 27869803 | PATU8988S | viability after 31 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | -0.1285869041418059 | [831] | [229,396,NaN] | -1 | hSpCas9 | negative selection | 9916683 | 127895072 | 127895095 | 4 | + | 27869803 | PATU8988S | viability after 31 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | -1.037444721893679 | [460] | [67,116,NaN] | -8 | hSpCas9 | negative selection | 9916684 | 127885914 | 127885937 | 4 | + | 27869803 | HPAFII | viability after 35 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | -1.761796455109322 | [94] | [24,1,NaN] | -7 | hSpCas9 | negative selection | 9999128 | 127885998 | 127886021 | 4 | - | 27869803 | HPAFII | viability after 35 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | -0.811321862502921 | [654] | [108,278,NaN] | -5 | hSpCas9 | negative selection | 9999129 | 127887430 | 127887453 | 4 | - | 27869803 | HPAFII | viability after 35 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.21538416533902272 | [615] | [243,494,NaN] | 1 | hSpCas9 | negative selection | 9999130 | 127891615 | 127891638 | 4 | - | 27869803 | HPAFII | viability after 35 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -1.5586652059859265 | [164] | [33,21,NaN] | -7 | hSpCas9 | negative selection | 9999131 | 127893839 | 127893862 | 4 | + | 27869803 | HPAFII | viability after 35 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | 1.4285266949414797 | [376] | [675,330,NaN] | 8 | hSpCas9 | negative selection | 9999132 | 127895072 | 127895095 | 4 | + | 27869803 | HPAFII | viability after 35 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | -0.14486163061476587 | [166] | [67,85,NaN] | -1 | hSpCas9 | negative selection | 9999133 | 127885914 | 127885937 | 4 | + | 27869803 | HPAFII | viability after 31 days | ATTGCCACTCGAAGTGCACATGG | PLK4 | ENSG00000142731 | -2.3599558716810627 | [94] | [18,0,NaN] | -8 | hSpCas9 | negative selection | 10081577 | 127885998 | 127886021 | 4 | - | 27869803 | HPAFII | viability after 31 days | TTGACTGTGTCAGTGTCGAAGGG | PLK4 | ENSG00000142731 | 0.075673646399532 | [654] | [317,462,NaN] | 0 | hSpCas9 | negative selection | 10081578 | 127887430 | 127887453 | 4 | - | 27869803 | HPAFII | viability after 31 days | TGAGGTGTCGGGTCTGCAAATGG | PLK4 | ENSG00000142731 | 0.3945624221180417 | [615] | [363,552,NaN] | 3 | hSpCas9 | negative selection | 10081579 | 127891615 | 127891638 | 4 | - | 27869803 | HPAFII | viability after 31 days | GAGGGTGGTCTATCAGCAAGAGG | PLK4 | ENSG00000142731 | -1.156174442687576 | [164] | [64,15,NaN] | -6 | hSpCas9 | negative selection | 10081580 | 127893839 | 127893862 | 4 | + | 27869803 | HPAFII | viability after 31 days | TAGTGCTGCTTCTCCAACACAGG | PLK4 | ENSG00000142731 | 1.3815134268514764 | [376] | [835,240,NaN] | 8 | hSpCas9 | negative selection | 10081581 | 127895072 | 127895095 | 4 | + | 27869803 | HPAFII | viability after 31 days | AAATGTTGGTTGGGCTACACAGG | PLK4 | ENSG00000142731 | -0.45350501161137213 | [166] | [55,81,NaN] | -3 | hSpCas9 | negative selection | 10081582 | 127886421 | 127886444 | 4 | + | 28162770 | P31FUJ | viability | GAAACCAGTAATAGTGGAAGGGG | PLK4 | ENSG00000142731 | -0.5188532629731444 | [138] | [113] | -4 | hSpCas9 | negative selection | 10213049 | 127893777 | 127893800 | 4 | - | 28162770 | P31FUJ | viability | GGGTAATTTGAATCCACAGAAGG | PLK4 | ENSG00000142731 | -0.10531246929246293 | [183] | [200] | -1 | hSpCas9 | negative selection | 10213050 | 127886605 | 127886628 | 4 | + | 28162770 | P31FUJ | viability | GAGGAGGTGAAAATGAAGAGAGG | PLK4 | ENSG00000142731 | -0.7473753772441372 | [109] | [76] | -5 | hSpCas9 | negative selection | 10213051 | 127887452 | 127887475 | 4 | + | 28162770 | P31FUJ | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -1.0065263485907028 | [105] | [61] | -6 | hSpCas9 | negative selection | 10213052 | 127890138 | 127890161 | 4 | - | 28162770 | P31FUJ | viability | CGATTCTGATAACCCCATGGTGG | PLK4 | ENSG00000142731 | -0.25552228091446216 | [191] | [188] | -2 | hSpCas9 | negative selection | 10213053 | 127891094 | 127891117 | 4 | + | 28162770 | P31FUJ | viability | GAGCATACTTGATTCAGAGGAGG | PLK4 | ENSG00000142731 | -1.6818812770537617 | [242] | [88] | -8 | hSpCas9 | negative selection | 10213054 | 127885995 | 127886018 | 4 | - | 28162770 | P31FUJ | viability | ACTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -0.4222800032780911 | [64] | [56] | -4 | hSpCas9 | negative selection | 10213055 | 127886118 | 127886141 | 4 | - | 28162770 | P31FUJ | viability | GACAGACTTAAACGATCTGCTGG | PLK4 | ENSG00000142731 | -0.30262365391195 | [126] | [120] | -3 | hSpCas9 | negative selection | 10213056 | 127886486 | 127886509 | 4 | - | 28162770 | P31FUJ | viability | CAGAGGAATAAGCTCTACGAAGG | PLK4 | ENSG00000142731 | -1.4254472823567748 | [63] | [27] | -7 | hSpCas9 | negative selection | 10213057 | 127886586 | 127886609 | 4 | + | 28162770 | P31FUJ | viability | TCAGTGTCCAAAAGATCAGGAGG | PLK4 | ENSG00000142731 | -0.8188353508550902 | [673] | [448] | -6 | hSpCas9 | negative selection | 10213058 | 127886421 | 127886444 | 4 | + | 28162770 | TF1 | viability | GAAACCAGTAATAGTGGAAGGGG | PLK4 | ENSG00000142731 | NaN | [NaN] | [57] | 1 | hSpCas9 | negative selection | 10382415 | 127893777 | 127893800 | 4 | - | 28162770 | TF1 | viability | GGGTAATTTGAATCCACAGAAGG | PLK4 | ENSG00000142731 | NaN | [NaN] | [129] | 1 | hSpCas9 | negative selection | 10382416 | 127886605 | 127886628 | 4 | + | 28162770 | TF1 | viability | GAGGAGGTGAAAATGAAGAGAGG | PLK4 | ENSG00000142731 | NaN | [NaN] | [9] | 1 | hSpCas9 | negative selection | 10382417 | 127887452 | 127887475 | 4 | + | 28162770 | TF1 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | NaN | [NaN] | [145] | 1 | hSpCas9 | negative selection | 10382418 | 127890138 | 127890161 | 4 | - | 28162770 | TF1 | viability | CGATTCTGATAACCCCATGGTGG | PLK4 | ENSG00000142731 | NaN | [NaN] | [76] | 1 | hSpCas9 | negative selection | 10382419 | 127891094 | 127891117 | 4 | + | 28162770 | TF1 | viability | GAGCATACTTGATTCAGAGGAGG | PLK4 | ENSG00000142731 | NaN | [NaN] | [41] | 1 | hSpCas9 | negative selection | 10382420 | 127885995 | 127886018 | 4 | - | 28162770 | TF1 | viability | ACTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | NaN | [NaN] | [39] | 1 | hSpCas9 | negative selection | 10382421 | 127886118 | 127886141 | 4 | - | 28162770 | TF1 | viability | GACAGACTTAAACGATCTGCTGG | PLK4 | ENSG00000142731 | NaN | [NaN] | [116] | 1 | hSpCas9 | negative selection | 10382422 | 127886486 | 127886509 | 4 | - | 28162770 | TF1 | viability | CAGAGGAATAAGCTCTACGAAGG | PLK4 | ENSG00000142731 | NaN | [NaN] | [1] | 1 | hSpCas9 | negative selection | 10382423 | 127886586 | 127886609 | 4 | + | 28162770 | TF1 | viability | TCAGTGTCCAAAAGATCAGGAGG | PLK4 | ENSG00000142731 | NaN | [NaN] | [115] | 1 | hSpCas9 | negative selection | 10382424 | 127886421 | 127886444 | 4 | + | 28162770 | SKM1 | viability | GAAACCAGTAATAGTGGAAGGGG | PLK4 | ENSG00000142731 | -0.5000736031346431 | [47] | [59] | -4 | hSpCas9 | negative selection | 10551781 | 127893777 | 127893800 | 4 | - | 28162770 | SKM1 | viability | GGGTAATTTGAATCCACAGAAGG | PLK4 | ENSG00000142731 | -1.0075573511780822 | [57] | [50] | -6 | hSpCas9 | negative selection | 10551782 | 127886605 | 127886628 | 4 | + | 28162770 | SKM1 | viability | GAGGAGGTGAAAATGAAGAGAGG | PLK4 | ENSG00000142731 | -1.2005133212757353 | [38] | [29] | -7 | hSpCas9 | negative selection | 10551783 | 127887452 | 127887475 | 4 | + | 28162770 | SKM1 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.9406461945206246 | [37] | [34] | -6 | hSpCas9 | negative selection | 10551784 | 127890138 | 127890161 | 4 | - | 28162770 | SKM1 | viability | CGATTCTGATAACCCCATGGTGG | PLK4 | ENSG00000142731 | -0.7631080089684369 | [47] | [49] | -5 | hSpCas9 | negative selection | 10551785 | 127891094 | 127891117 | 4 | + | 28162770 | SKM1 | viability | GAGCATACTTGATTCAGAGGAGG | PLK4 | ENSG00000142731 | -1.2694606749932271 | [89] | [65] | -7 | hSpCas9 | negative selection | 10551786 | 127885995 | 127886018 | 4 | - | 28162770 | SKM1 | viability | ACTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -2.6293566200796095 | [20] | [5] | -9 | hSpCas9 | negative selection | 10551787 | 127886118 | 127886141 | 4 | - | 28162770 | SKM1 | viability | GACAGACTTAAACGATCTGCTGG | PLK4 | ENSG00000142731 | 0.45810622117072974 | [27] | [67] | 4 | hSpCas9 | negative selection | 10551788 | 127886486 | 127886509 | 4 | - | 28162770 | SKM1 | viability | CAGAGGAATAAGCTCTACGAAGG | PLK4 | ENSG00000142731 | -1.5224414161630975 | [12] | [7] | -7 | hSpCas9 | negative selection | 10551789 | 127886586 | 127886609 | 4 | + | 28162770 | SKM1 | viability | TCAGTGTCCAAAAGATCAGGAGG | PLK4 | ENSG00000142731 | -0.28989107956658455 | [138] | [200] | -2 | hSpCas9 | negative selection | 10551790 | 127886421 | 127886444 | 4 | + | 28162770 | SKM1 | viability | GAAACCAGTAATAGTGGAAGGGG | PLK4 | ENSG00000142731 | -0.5000736031346431 | [47] | [59] | -4 | hSpCas9 | negative selection | 10721147 | 127893777 | 127893800 | 4 | - | 28162770 | SKM1 | viability | GGGTAATTTGAATCCACAGAAGG | PLK4 | ENSG00000142731 | -1.0075573511780822 | [57] | [50] | -6 | hSpCas9 | negative selection | 10721148 | 127886605 | 127886628 | 4 | + | 28162770 | SKM1 | viability | GAGGAGGTGAAAATGAAGAGAGG | PLK4 | ENSG00000142731 | -1.2005133212757353 | [38] | [29] | -7 | hSpCas9 | negative selection | 10721149 | 127887452 | 127887475 | 4 | + | 28162770 | SKM1 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.9406461945206246 | [37] | [34] | -6 | hSpCas9 | negative selection | 10721150 | 127890138 | 127890161 | 4 | - | 28162770 | SKM1 | viability | CGATTCTGATAACCCCATGGTGG | PLK4 | ENSG00000142731 | -0.7631080089684369 | [47] | [49] | -5 | hSpCas9 | negative selection | 10721151 | 127891094 | 127891117 | 4 | + | 28162770 | SKM1 | viability | GAGCATACTTGATTCAGAGGAGG | PLK4 | ENSG00000142731 | -1.2694606749932271 | [89] | [65] | -7 | hSpCas9 | negative selection | 10721152 | 127885995 | 127886018 | 4 | - | 28162770 | SKM1 | viability | ACTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -2.6293566200796095 | [20] | [5] | -9 | hSpCas9 | negative selection | 10721153 | 127886118 | 127886141 | 4 | - | 28162770 | SKM1 | viability | GACAGACTTAAACGATCTGCTGG | PLK4 | ENSG00000142731 | 0.45810622117072974 | [27] | [67] | 4 | hSpCas9 | negative selection | 10721154 | 127886486 | 127886509 | 4 | - | 28162770 | SKM1 | viability | CAGAGGAATAAGCTCTACGAAGG | PLK4 | ENSG00000142731 | -1.5224414161630975 | [12] | [7] | -7 | hSpCas9 | negative selection | 10721155 | 127886586 | 127886609 | 4 | + | 28162770 | SKM1 | viability | TCAGTGTCCAAAAGATCAGGAGG | PLK4 | ENSG00000142731 | -0.28989107956658455 | [138] | [200] | -2 | hSpCas9 | negative selection | 10721156 | 127886421 | 127886444 | 4 | + | 28162770 | PL21 | viability | GAAACCAGTAATAGTGGAAGGGG | PLK4 | ENSG00000142731 | -0.8231928893413035 | [186] | [45] | -5 | hSpCas9 | negative selection | 10890513 | 127893777 | 127893800 | 4 | - | 28162770 | PL21 | viability | GGGTAATTTGAATCCACAGAAGG | PLK4 | ENSG00000142731 | -0.03743921066180375 | [190] | [80] | 0 | hSpCas9 | negative selection | 10890514 | 127886605 | 127886628 | 4 | + | 28162770 | PL21 | viability | GAGGAGGTGAAAATGAAGAGAGG | PLK4 | ENSG00000142731 | -1.0597275122657908 | [181] | [37] | -6 | hSpCas9 | negative selection | 10890515 | 127887452 | 127887475 | 4 | + | 28162770 | PL21 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.7279674670288943 | [136] | [35] | -5 | hSpCas9 | negative selection | 10890516 | 127890138 | 127890161 | 4 | - | 28162770 | PL21 | viability | CGATTCTGATAACCCCATGGTGG | PLK4 | ENSG00000142731 | 1.2766377519633636 | [201] | [212] | 9 | hSpCas9 | negative selection | 10890517 | 127891094 | 127891117 | 4 | + | 28162770 | PL21 | viability | GAGCATACTTGATTCAGAGGAGG | PLK4 | ENSG00000142731 | -1.0069048425136917 | [373] | [80] | -6 | hSpCas9 | negative selection | 10890518 | 127885995 | 127886018 | 4 | - | 28162770 | PL21 | viability | ACTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | 0.07460873240546118 | [23] | [10] | 0 | hSpCas9 | negative selection | 10890519 | 127886118 | 127886141 | 4 | - | 28162770 | PL21 | viability | GACAGACTTAAACGATCTGCTGG | PLK4 | ENSG00000142731 | -1.1217884803980422 | [109] | [21] | -6 | hSpCas9 | negative selection | 10890520 | 127886486 | 127886509 | 4 | - | 28162770 | PL21 | viability | CAGAGGAATAAGCTCTACGAAGG | PLK4 | ENSG00000142731 | -0.7473929656165441 | [26] | [6] | -5 | hSpCas9 | negative selection | 10890521 | 127886586 | 127886609 | 4 | + | 28162770 | PL21 | viability | TCAGTGTCCAAAAGATCAGGAGG | PLK4 | ENSG00000142731 | -0.8304487053441028 | [428] | [104] | -5 | hSpCas9 | negative selection | 10890522 | 127886421 | 127886444 | 4 | + | 28162770 | P31FUJ | viability | GAAACCAGTAATAGTGGAAGGGG | PLK4 | ENSG00000142731 | -0.5188532629731444 | [138] | [113] | -4 | hSpCas9 | negative selection | 11059879 | 127893777 | 127893800 | 4 | - | 28162770 | P31FUJ | viability | GGGTAATTTGAATCCACAGAAGG | PLK4 | ENSG00000142731 | -0.10531246929246293 | [183] | [200] | -1 | hSpCas9 | negative selection | 11059880 | 127886605 | 127886628 | 4 | + | 28162770 | P31FUJ | viability | GAGGAGGTGAAAATGAAGAGAGG | PLK4 | ENSG00000142731 | -0.7473753772441372 | [109] | [76] | -5 | hSpCas9 | negative selection | 11059881 | 127887452 | 127887475 | 4 | + | 28162770 | P31FUJ | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -1.0065263485907028 | [105] | [61] | -6 | hSpCas9 | negative selection | 11059882 | 127890138 | 127890161 | 4 | - | 28162770 | P31FUJ | viability | CGATTCTGATAACCCCATGGTGG | PLK4 | ENSG00000142731 | -0.25552228091446216 | [191] | [188] | -2 | hSpCas9 | negative selection | 11059883 | 127891094 | 127891117 | 4 | + | 28162770 | P31FUJ | viability | GAGCATACTTGATTCAGAGGAGG | PLK4 | ENSG00000142731 | -1.6818812770537617 | [242] | [88] | -8 | hSpCas9 | negative selection | 11059884 | 127885995 | 127886018 | 4 | - | 28162770 | P31FUJ | viability | ACTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -0.4222800032780911 | [64] | [56] | -4 | hSpCas9 | negative selection | 11059885 | 127886118 | 127886141 | 4 | - | 28162770 | P31FUJ | viability | GACAGACTTAAACGATCTGCTGG | PLK4 | ENSG00000142731 | -0.30262365391195 | [126] | [120] | -3 | hSpCas9 | negative selection | 11059886 | 127886486 | 127886509 | 4 | - | 28162770 | P31FUJ | viability | CAGAGGAATAAGCTCTACGAAGG | PLK4 | ENSG00000142731 | -1.4254472823567748 | [63] | [27] | -7 | hSpCas9 | negative selection | 11059887 | 127886586 | 127886609 | 4 | + | 28162770 | P31FUJ | viability | TCAGTGTCCAAAAGATCAGGAGG | PLK4 | ENSG00000142731 | -0.8188353508550902 | [673] | [448] | -6 | hSpCas9 | negative selection | 11059888 | 127886421 | 127886444 | 4 | + | 28162770 | OCIAML5 | viability | GAAACCAGTAATAGTGGAAGGGG | PLK4 | ENSG00000142731 | -0.6897951419651199 | [83] | [93] | -4 | hSpCas9 | negative selection | 11229245 | 127893777 | 127893800 | 4 | - | 28162770 | OCIAML5 | viability | GGGTAATTTGAATCCACAGAAGG | PLK4 | ENSG00000142731 | -0.3583721277101549 | [173] | [244] | -3 | hSpCas9 | negative selection | 11229246 | 127886605 | 127886628 | 4 | + | 28162770 | OCIAML5 | viability | GAGGAGGTGAAAATGAAGAGAGG | PLK4 | ENSG00000142731 | -7.538567098047215 | [102] | [0] | -9 | hSpCas9 | negative selection | 11229247 | 127887452 | 127887475 | 4 | + | 28162770 | OCIAML5 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.5389086856043666 | [65] | [81] | -4 | hSpCas9 | negative selection | 11229248 | 127890138 | 127890161 | 4 | - | 28162770 | OCIAML5 | viability | CGATTCTGATAACCCCATGGTGG | PLK4 | ENSG00000142731 | -0.7356570787486865 | [118] | [128] | -5 | hSpCas9 | negative selection | 11229249 | 127891094 | 127891117 | 4 | + | 28162770 | OCIAML5 | viability | GAGCATACTTGATTCAGAGGAGG | PLK4 | ENSG00000142731 | -4.990830640819849 | [228] | [12] | -9 | hSpCas9 | negative selection | 11229250 | 127885995 | 127886018 | 4 | - | 28162770 | OCIAML5 | viability | ACTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -0.8114245863666509 | [34] | [35] | -5 | hSpCas9 | negative selection | 11229251 | 127886118 | 127886141 | 4 | - | 28162770 | OCIAML5 | viability | GACAGACTTAAACGATCTGCTGG | PLK4 | ENSG00000142731 | 0.638568547309006 | [78] | [221] | 5 | hSpCas9 | negative selection | 11229252 | 127886486 | 127886509 | 4 | - | 28162770 | OCIAML5 | viability | CAGAGGAATAAGCTCTACGAAGG | PLK4 | ENSG00000142731 | -5.021991572306309 | [17] | [0] | -9 | hSpCas9 | negative selection | 11229253 | 127886586 | 127886609 | 4 | + | 28162770 | OCIAML5 | viability | TCAGTGTCCAAAAGATCAGGAGG | PLK4 | ENSG00000142731 | -0.7830637832435616 | [346] | [363] | -5 | hSpCas9 | negative selection | 11229254 | 127886421 | 127886444 | 4 | + | 28162770 | EOL1 | viability | GAAACCAGTAATAGTGGAAGGGG | PLK4 | ENSG00000142731 | -0.28865547831125293 | [312] | [134] | -2 | hSpCas9 | negative selection | 11398611 | 127893777 | 127893800 | 4 | - | 28162770 | EOL1 | viability | GGGTAATTTGAATCCACAGAAGG | PLK4 | ENSG00000142731 | -1.4380223078141738 | [251] | [48] | -7 | hSpCas9 | negative selection | 11398612 | 127886605 | 127886628 | 4 | + | 28162770 | EOL1 | viability | GAGGAGGTGAAAATGAAGAGAGG | PLK4 | ENSG00000142731 | -1.938950228524603 | [261] | [35] | -8 | hSpCas9 | negative selection | 11398613 | 127887452 | 127887475 | 4 | + | 28162770 | EOL1 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -1.1694283766384794 | [221] | [51] | -7 | hSpCas9 | negative selection | 11398614 | 127890138 | 127890161 | 4 | - | 28162770 | EOL1 | viability | CGATTCTGATAACCCCATGGTGG | PLK4 | ENSG00000142731 | -1.1097221305142115 | [425] | [103] | -6 | hSpCas9 | negative selection | 11398615 | 127891094 | 127891117 | 4 | + | 28162770 | EOL1 | viability | GAGCATACTTGATTCAGAGGAGG | PLK4 | ENSG00000142731 | -2.2161772534232034 | [537] | [60] | -8 | hSpCas9 | negative selection | 11398616 | 127885995 | 127886018 | 4 | - | 28162770 | EOL1 | viability | ACTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -1.897453926451471 | [98] | [13] | -8 | hSpCas9 | negative selection | 11398617 | 127886118 | 127886141 | 4 | - | 28162770 | EOL1 | viability | GACAGACTTAAACGATCTGCTGG | PLK4 | ENSG00000142731 | 0.4140634868086548 | [150] | [105] | 4 | hSpCas9 | negative selection | 11398618 | 127886486 | 127886509 | 4 | - | 28162770 | EOL1 | viability | CAGAGGAATAAGCTCTACGAAGG | PLK4 | ENSG00000142731 | -3.5990141844864785 | [68] | [2] | -9 | hSpCas9 | negative selection | 11398619 | 127886586 | 127886609 | 4 | + | 28162770 | EOL1 | viability | TCAGTGTCCAAAAGATCAGGAGG | PLK4 | ENSG00000142731 | -1.6394551105149757 | [614] | [103] | -7 | hSpCas9 | negative selection | 11398620 | 127886421 | 127886444 | 4 | + | 28162770 | MOLM13 | viability | GAAACCAGTAATAGTGGAAGGGG | PLK4 | ENSG00000142731 | -0.8148889595876299 | [308] | [126] | -4 | hSpCas9 | negative selection | 11567977 | 127893777 | 127893800 | 4 | - | 28162770 | MOLM13 | viability | GGGTAATTTGAATCCACAGAAGG | PLK4 | ENSG00000142731 | -1.1665932550203764 | [325] | [104] | -6 | hSpCas9 | negative selection | 11567978 | 127886605 | 127886628 | 4 | + | 28162770 | MOLM13 | viability | GAGGAGGTGAAAATGAAGAGAGG | PLK4 | ENSG00000142731 | -1.4785295782505772 | [184] | [47] | -6 | hSpCas9 | negative selection | 11567979 | 127887452 | 127887475 | 4 | + | 28162770 | MOLM13 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | 0.40967476759928306 | [176] | [169] | 3 | hSpCas9 | negative selection | 11567980 | 127890138 | 127890161 | 4 | - | 28162770 | MOLM13 | viability | CGATTCTGATAACCCCATGGTGG | PLK4 | ENSG00000142731 | -1.0903203915708921 | [373] | [126] | -5 | hSpCas9 | negative selection | 11567981 | 127891094 | 127891117 | 4 | + | 28162770 | MOLM13 | viability | GAGCATACTTGATTCAGAGGAGG | PLK4 | ENSG00000142731 | -2.444999954685383 | [481] | [63] | -8 | hSpCas9 | negative selection | 11567982 | 127885995 | 127886018 | 4 | - | 28162770 | MOLM13 | viability | ACTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -2.833280153175986 | [68] | [6] | -8 | hSpCas9 | negative selection | 11567983 | 127886118 | 127886141 | 4 | - | 28162770 | MOLM13 | viability | GACAGACTTAAACGATCTGCTGG | PLK4 | ENSG00000142731 | 0.7020368259412177 | [226] | [266] | 5 | hSpCas9 | negative selection | 11567984 | 127886486 | 127886509 | 4 | - | 28162770 | MOLM13 | viability | CAGAGGAATAAGCTCTACGAAGG | PLK4 | ENSG00000142731 | -2.6024999463468195 | [41] | [4] | -8 | hSpCas9 | negative selection | 11567985 | 127886586 | 127886609 | 4 | + | 28162770 | MOLM13 | viability | TCAGTGTCCAAAAGATCAGGAGG | PLK4 | ENSG00000142731 | -0.24589688723409875 | [637] | [388] | -1 | hSpCas9 | negative selection | 11567986 | 127886421 | 127886444 | 4 | + | 28162770 | HEL | viability | GAAACCAGTAATAGTGGAAGGGG | PLK4 | ENSG00000142731 | 0.16917525611505765 | [217] | [156] | 1 | hSpCas9 | negative selection | 11737343 | 127893777 | 127893800 | 4 | - | 28162770 | HEL | viability | GGGTAATTTGAATCCACAGAAGG | PLK4 | ENSG00000142731 | -1.9858506011210575 | [234] | [37] | -8 | hSpCas9 | negative selection | 11737344 | 127886605 | 127886628 | 4 | + | 28162770 | HEL | viability | GAGGAGGTGAAAATGAAGAGAGG | PLK4 | ENSG00000142731 | -1.989529383499156 | [185] | [29] | -8 | hSpCas9 | negative selection | 11737345 | 127887452 | 127887475 | 4 | + | 28162770 | HEL | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.6316235796349497 | [178] | [73] | -4 | hSpCas9 | negative selection | 11737346 | 127890138 | 127890161 | 4 | - | 28162770 | HEL | viability | CGATTCTGATAACCCCATGGTGG | PLK4 | ENSG00000142731 | -0.25342535701510316 | [267] | [143] | -2 | hSpCas9 | negative selection | 11737347 | 127891094 | 127891117 | 4 | + | 28162770 | HEL | viability | GAGCATACTTGATTCAGAGGAGG | PLK4 | ENSG00000142731 | -3.3943504867348633 | [393] | [23] | -9 | hSpCas9 | negative selection | 11737348 | 127885995 | 127886018 | 4 | - | 28162770 | HEL | viability | ACTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -5.749578590778404 | [83] | [0] | -9 | hSpCas9 | negative selection | 11737349 | 127886118 | 127886141 | 4 | - | 28162770 | HEL | viability | GACAGACTTAAACGATCTGCTGG | PLK4 | ENSG00000142731 | 0.7482319608476706 | [144] | [155] | 6 | hSpCas9 | negative selection | 11737350 | 127886486 | 127886509 | 4 | - | 28162770 | HEL | viability | CAGAGGAATAAGCTCTACGAAGG | PLK4 | ENSG00000142731 | -5.766652104137345 | [84] | [0] | -9 | hSpCas9 | negative selection | 11737351 | 127886586 | 127886609 | 4 | + | 28162770 | HEL | viability | TCAGTGTCCAAAAGATCAGGAGG | PLK4 | ENSG00000142731 | -1.2336436748446433 | [502] | [136] | -6 | hSpCas9 | negative selection | 11737352 | 127886421 | 127886444 | 4 | + | 28162770 | MV411 | viability | GAAACCAGTAATAGTGGAAGGGG | PLK4 | ENSG00000142731 | -1.5950211722307446 | [207] | [57] | -7 | hSpCas9 | negative selection | 11906709 | 127893777 | 127893800 | 4 | - | 28162770 | MV411 | viability | GGGTAATTTGAATCCACAGAAGG | PLK4 | ENSG00000142731 | 0.04812874255936872 | [154] | [134] | 0 | hSpCas9 | negative selection | 11906710 | 127886605 | 127886628 | 4 | + | 28162770 | MV411 | viability | GAGGAGGTGAAAATGAAGAGAGG | PLK4 | ENSG00000142731 | -0.5046349357736392 | [127] | [75] | -4 | hSpCas9 | negative selection | 11906711 | 127887452 | 127887475 | 4 | + | 28162770 | MV411 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.2725695080976111 | [151] | [105] | -2 | hSpCas9 | negative selection | 11906712 | 127890138 | 127890161 | 4 | - | 28162770 | MV411 | viability | CGATTCTGATAACCCCATGGTGG | PLK4 | ENSG00000142731 | -0.8900659729671596 | [230] | [104] | -6 | hSpCas9 | negative selection | 11906713 | 127891094 | 127891117 | 4 | + | 28162770 | MV411 | viability | GAGCATACTTGATTCAGAGGAGG | PLK4 | ENSG00000142731 | -1.2313965990770377 | [261] | [93] | -7 | hSpCas9 | negative selection | 11906714 | 127885995 | 127886018 | 4 | - | 28162770 | MV411 | viability | ACTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -1.074490544104587 | [34] | [13] | -6 | hSpCas9 | negative selection | 11906715 | 127886118 | 127886141 | 4 | - | 28162770 | MV411 | viability | GACAGACTTAAACGATCTGCTGG | PLK4 | ENSG00000142731 | -0.28167171520486356 | [113] | [78] | -2 | hSpCas9 | negative selection | 11906716 | 127886486 | 127886509 | 4 | - | 28162770 | MV411 | viability | CAGAGGAATAAGCTCTACGAAGG | PLK4 | ENSG00000142731 | -0.0004899626608101393 | [18] | [15] | 0 | hSpCas9 | negative selection | 11906717 | 127886586 | 127886609 | 4 | + | 28162770 | MV411 | viability | TCAGTGTCCAAAAGATCAGGAGG | PLK4 | ENSG00000142731 | -0.6184257765656884 | [389] | [213] | -4 | hSpCas9 | negative selection | 11906718 | 127886421 | 127886444 | 4 | + | 28162770 | MONOMAC1 | viability | GAAACCAGTAATAGTGGAAGGGG | PLK4 | ENSG00000142731 | -0.9208270524780267 | [108] | [65] | -6 | hSpCas9 | negative selection | 12076075 | 127893777 | 127893800 | 4 | - | 28162770 | MONOMAC1 | viability | GGGTAATTTGAATCCACAGAAGG | PLK4 | ENSG00000142731 | 0.7556574381620897 | [123] | [239] | 7 | hSpCas9 | negative selection | 12076076 | 127886605 | 127886628 | 4 | + | 28162770 | MONOMAC1 | viability | GAGGAGGTGAAAATGAAGAGAGG | PLK4 | ENSG00000142731 | -1.4241057556054748 | [102] | [43] | -8 | hSpCas9 | negative selection | 12076077 | 127887452 | 127887475 | 4 | + | 28162770 | MONOMAC1 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | 0.95106179192958 | [73] | [163] | 8 | hSpCas9 | negative selection | 12076078 | 127890138 | 127890161 | 4 | - | 28162770 | MONOMAC1 | viability | CGATTCTGATAACCCCATGGTGG | PLK4 | ENSG00000142731 | 0.03178184343632702 | [127] | [149] | 0 | hSpCas9 | negative selection | 12076079 | 127891094 | 127891117 | 4 | + | 28162770 | MONOMAC1 | viability | GAGCATACTTGATTCAGAGGAGG | PLK4 | ENSG00000142731 | -1.8036944188800286 | [200] | [65] | -8 | hSpCas9 | negative selection | 12076080 | 127885995 | 127886018 | 4 | - | 28162770 | MONOMAC1 | viability | ACTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -0.4315021006965767 | [39] | [33] | -4 | hSpCas9 | negative selection | 12076081 | 127886118 | 127886141 | 4 | - | 28162770 | MONOMAC1 | viability | GACAGACTTAAACGATCTGCTGG | PLK4 | ENSG00000142731 | -0.06168499416466733 | [60] | [66] | 0 | hSpCas9 | negative selection | 12076082 | 127886486 | 127886509 | 4 | - | 28162770 | MONOMAC1 | viability | CAGAGGAATAAGCTCTACGAAGG | PLK4 | ENSG00000142731 | -3.9340024412257604 | [39] | [2] | -9 | hSpCas9 | negative selection | 12076083 | 127886586 | 127886609 | 4 | + | 28162770 | MONOMAC1 | viability | TCAGTGTCCAAAAGATCAGGAGG | PLK4 | ENSG00000142731 | -1.0351491646826596 | [319] | [178] | -7 | hSpCas9 | negative selection | 12076084 | 127886421 | 127886444 | 4 | + | 28162770 | OCIAML2 | viability | GAAACCAGTAATAGTGGAAGGGG | PLK4 | ENSG00000142731 | -0.9345769250019514 | [39] | [115] | -6 | hSpCas9 | negative selection | 12245441 | 127893777 | 127893800 | 4 | - | 28162770 | OCIAML2 | viability | GGGTAATTTGAATCCACAGAAGG | PLK4 | ENSG00000142731 | -1.075770207900948 | [26] | [70] | -6 | hSpCas9 | negative selection | 12245442 | 127886605 | 127886628 | 4 | + | 28162770 | OCIAML2 | viability | GAGGAGGTGAAAATGAAGAGAGG | PLK4 | ENSG00000142731 | -2.108059745857453 | [20] | [26] | -8 | hSpCas9 | negative selection | 12245443 | 127887452 | 127887475 | 4 | + | 28162770 | OCIAML2 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | 0.12928301694496658 | [15] | [96] | 1 | hSpCas9 | negative selection | 12245444 | 127890138 | 127890161 | 4 | - | 28162770 | OCIAML2 | viability | CGATTCTGATAACCCCATGGTGG | PLK4 | ENSG00000142731 | -0.9058452064586354 | [47] | [141] | -6 | hSpCas9 | negative selection | 12245445 | 127891094 | 127891117 | 4 | + | 28162770 | OCIAML2 | viability | GAGCATACTTGATTCAGAGGAGG | PLK4 | ENSG00000142731 | -1.5980091317183887 | [70] | [129] | -7 | hSpCas9 | negative selection | 12245446 | 127885995 | 127886018 | 4 | - | 28162770 | OCIAML2 | viability | ACTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -0.2576361019079627 | [10] | [50] | -2 | hSpCas9 | negative selection | 12245447 | 127886118 | 127886141 | 4 | - | 28162770 | OCIAML2 | viability | GACAGACTTAAACGATCTGCTGG | PLK4 | ENSG00000142731 | 1.2842576769213072 | [9] | [134] | 9 | hSpCas9 | negative selection | 12245448 | 127886486 | 127886509 | 4 | - | 28162770 | OCIAML2 | viability | CAGAGGAATAAGCTCTACGAAGG | PLK4 | ENSG00000142731 | -2.0555923259633175 | [11] | [15] | -8 | hSpCas9 | negative selection | 12245449 | 127886586 | 127886609 | 4 | + | 28162770 | OCIAML2 | viability | TCAGTGTCCAAAAGATCAGGAGG | PLK4 | ENSG00000142731 | -0.13998451325368988 | [65] | [331] | -1 | hSpCas9 | negative selection | 12245450 | 127886421 | 127886444 | 4 | + | 28162770 | OCIAML3 | viability | GAAACCAGTAATAGTGGAAGGGG | PLK4 | ENSG00000142731 | -0.32551880439826136 | [43] | [105] | -3 | hSpCas9 | negative selection | 12414807 | 127893777 | 127893800 | 4 | - | 28162770 | OCIAML3 | viability | GGGTAATTTGAATCCACAGAAGG | PLK4 | ENSG00000142731 | -0.05263440815068965 | [55] | [162] | 0 | hSpCas9 | negative selection | 12414808 | 127886605 | 127886628 | 4 | + | 28162770 | OCIAML3 | viability | GAGGAGGTGAAAATGAAGAGAGG | PLK4 | ENSG00000142731 | -3.2378638300988882 | [24] | [7] | -9 | hSpCas9 | negative selection | 12414809 | 127887452 | 127887475 | 4 | + | 28162770 | OCIAML3 | viability | AGACTGAAACCGTACAACAGTGG | PLK4 | ENSG00000142731 | -0.5756291110093084 | [38] | [78] | -4 | hSpCas9 | negative selection | 12414810 | 127890138 | 127890161 | 4 | - | 28162770 | OCIAML3 | viability | CGATTCTGATAACCCCATGGTGG | PLK4 | ENSG00000142731 | -1.4766506896860043 | [58] | [63] | -7 | hSpCas9 | negative selection | 12414811 | 127891094 | 127891117 | 4 | + | 28162770 | OCIAML3 | viability | GAGCATACTTGATTCAGAGGAGG | PLK4 | ENSG00000142731 | -1.6945345162781278 | [103] | [96] | -8 | hSpCas9 | negative selection | 12414812 | 127885995 | 127886018 | 4 | - | 28162770 | OCIAML3 | viability | ACTGTGTCAGTGTCGAAGGGTGG | PLK4 | ENSG00000142731 | -3.2378638300988882 | [24] | [7] | -9 | hSpCas9 | negative selection | 12414813 | 127886118 | 127886141 | 4 | - | 28162770 | OCIAML3 | viability | GACAGACTTAAACGATCTGCTGG | PLK4 | ENSG00000142731 | -0.10368201374108232 | [20] | [58] | -1 | hSpCas9 | negative selection | 12414814 | 127886486 | 127886509 | 4 | - | 28162770 | OCIAML3 | viability | CAGAGGAATAAGCTCTACGAAGG | PLK4 | ENSG00000142731 | -4.763932641766476 | [17] | [1] | -9 | hSpCas9 | negative selection | 12414815 | 127886586 | 127886609 | 4 | + | 28162770 | OCIAML3 | viability | TCAGTGTCCAAAAGATCAGGAGG | PLK4 | ENSG00000142731 | -0.23916492296406566 | [103] | [265] | -2 | hSpCas9 | negative selection | 12414816 |