| 18973026 | 18973049 | 14 | + | 26472758 | Jiyoye | viability | ACTGACAGGCCGTACAATGCCAG | POTEM | ENSG00000222036 | 0.9209910352628907 | [380] | [543] | 6 | hSpCas9 | negative selection | 124223 | 18988308 | 18988331 | 14 | - | 26472758 | Jiyoye | viability | CAGCAGTGGCACCGTTAGGCAGG | POTEM | ENSG00000222036 | 0.20072450403844688 | [179] | [155] | 1 | hSpCas9 | negative selection | 124239 | 18967859 | 18967882 | 14 | + | 26472758 | Jiyoye | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | -0.6555603738420891 | [93] | [44] | -5 | hSpCas9 | negative selection | 124240 | 18967517 | 18967540 | 14 | - | 26472758 | Jiyoye | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | 0.11171949797970218 | [107] | [87] | 0 | hSpCas9 | negative selection | 124244 | 18988322 | 18988345 | 14 | - | 26472758 | Jiyoye | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -0.9473573788134164 | [178] | [69] | -6 | hSpCas9 | negative selection | 124247 | 18967536 | 18967559 | 14 | + | 26472758 | Jiyoye | viability | ATTTGGTCTCAGAAGCAAGATGG | POTEM | ENSG00000222036 | -0.8001495917416328 | [126] | [54] | -5 | hSpCas9 | negative selection | 124250 | 18988322 | 18988345 | 14 | - | 26472758 | Jiyoye | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -0.9473573788134164 | [178] | [69] | -6 | hSpCas9 | negative selection | 124255 | 18967859 | 18967882 | 14 | + | 26472758 | Jiyoye | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | -0.6555603738420891 | [93] | [44] | -5 | hSpCas9 | negative selection | 124266 | 18967517 | 18967540 | 14 | - | 26472758 | Jiyoye | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | 0.11171949797970218 | [107] | [87] | 0 | hSpCas9 | negative selection | 124269 | 18967751 | 18967774 | 14 | - | 26472758 | Jiyoye | viability | GCTCCTGAGTGTCTTCATAGCAG | POTEM | ENSG00000222036 | -1.5010692217486206 | [532] | [141] | -7 | hSpCas9 | negative selection | 124289 | 18967640 | 18967663 | 14 | - | 26472758 | Jiyoye | viability | GCTCCTGAGTGTCTTCATAGCAG | POTEM | ENSG00000222036 | -1.5010692217486206 | [532] | [141] | -7 | hSpCas9 | negative selection | 124293 | 18967823 | 18967846 | 14 | + | 26472758 | Jiyoye | viability | GCAAGAGCAAAGTGGGCCCCTGG | POTEM | ENSG00000222036 | 0.831928035617929 | [110] | [148] | 6 | hSpCas9 | negative selection | 124311 | 18985460 | 18985483 | 14 | + | 26472758 | Jiyoye | viability | AAGTGAAAATAGCCAGCCAGAGG | POTEM | ENSG00000222036 | -1.960195684142656 | [257] | [49] | -8 | hSpCas9 | negative selection | 124312 | 18967841 | 18967864 | 14 | - | 26472758 | Jiyoye | viability | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | 0.32220025248328144 | [506] | [477] | 2 | hSpCas9 | negative selection | 124322 | 18967629 | 18967652 | 14 | - | 26472758 | Jiyoye | viability | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | 0.635127328184222 | [221] | [259] | 4 | hSpCas9 | negative selection | 124323 | 18988308 | 18988331 | 14 | - | 26472758 | Jiyoye | viability | CAGCAGTGGCACCGTTAGGCAGG | POTEM | ENSG00000222036 | 0.20072450403844688 | [179] | [155] | 1 | hSpCas9 | negative selection | 124325 | 18967859 | 18967882 | 14 | + | 26472758 | Jiyoye | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | -0.6555603738420891 | [93] | [44] | -5 | hSpCas9 | negative selection | 124327 | 18967517 | 18967540 | 14 | - | 26472758 | Jiyoye | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | 0.11171949797970218 | [107] | [87] | 0 | hSpCas9 | negative selection | 124330 | 18988322 | 18988345 | 14 | - | 26472758 | Jiyoye | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -0.9473573788134164 | [178] | [69] | -6 | hSpCas9 | negative selection | 124333 | 18967536 | 18967559 | 14 | + | 26472758 | Jiyoye | viability | ATTTGGTCTCAGAAGCAAGATGG | POTEM | ENSG00000222036 | -0.8001495917416328 | [126] | [54] | -5 | hSpCas9 | negative selection | 124336 | 18988354 | 18988377 | 14 | - | 26472758 | Jiyoye | viability | GGTGTTCTGCTTTTCCTTGGTGG | POTEM | ENSG00000222036 | -2.391190757324476 | [319] | [45] | -8 | hSpCas9 | negative selection | 124339 | 18973026 | 18973049 | 14 | + | 26472758 | KBM7 | viability | ACTGACAGGCCGTACAATGCCAG | POTEM | ENSG00000222036 | 0.28685615017182164 | [1436,1478] | [857,826] | 3 | hSpCas9 | negative selection | 315341 | 18988308 | 18988331 | 14 | - | 26472758 | KBM7 | viability | CAGCAGTGGCACCGTTAGGCAGG | POTEM | ENSG00000222036 | 0.46181851934356877 | [572,472] | [364,311] | 5 | hSpCas9 | negative selection | 315357 | 18967859 | 18967882 | 14 | + | 26472758 | KBM7 | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | 0.33249529913958975 | [349,193] | [192,124] | 3 | hSpCas9 | negative selection | 315358 | 18967517 | 18967540 | 14 | - | 26472758 | KBM7 | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | -1.6128514843710589 | [894,734] | [121,126] | -8 | hSpCas9 | negative selection | 315362 | 18988322 | 18988345 | 14 | - | 26472758 | KBM7 | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -1.4801223273757618 | [725,951] | [180,110] | -8 | hSpCas9 | negative selection | 315365 | 18967536 | 18967559 | 14 | + | 26472758 | KBM7 | viability | ATTTGGTCTCAGAAGCAAGATGG | POTEM | ENSG00000222036 | 0.4829554474249492 | [287,361] | [186,243] | 5 | hSpCas9 | negative selection | 315368 | 18988322 | 18988345 | 14 | - | 26472758 | KBM7 | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -1.4801223273757618 | [725,951] | [180,110] | -8 | hSpCas9 | negative selection | 315373 | 18967859 | 18967882 | 14 | + | 26472758 | KBM7 | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | 0.33249529913958975 | [349,193] | [192,124] | 3 | hSpCas9 | negative selection | 315384 | 18967517 | 18967540 | 14 | - | 26472758 | KBM7 | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | -1.6128514843710589 | [894,734] | [121,126] | -8 | hSpCas9 | negative selection | 315387 | 18967751 | 18967774 | 14 | - | 26472758 | KBM7 | viability | GCTCCTGAGTGTCTTCATAGCAG | POTEM | ENSG00000222036 | -0.5633801900289332 | [1309,1507] | [458,448] | -5 | hSpCas9 | negative selection | 315407 | 18967640 | 18967663 | 14 | - | 26472758 | KBM7 | viability | GCTCCTGAGTGTCTTCATAGCAG | POTEM | ENSG00000222036 | -0.5633801900289332 | [1309,1507] | [458,448] | -5 | hSpCas9 | negative selection | 315411 | 18967823 | 18967846 | 14 | + | 26472758 | KBM7 | viability | GCAAGAGCAAAGTGGGCCCCTGG | POTEM | ENSG00000222036 | 0.5620998220424517 | [446,322] | [279,249] | 6 | hSpCas9 | negative selection | 315429 | 18985460 | 18985483 | 14 | + | 26472758 | KBM7 | viability | AAGTGAAAATAGCCAGCCAGAGG | POTEM | ENSG00000222036 | -1.6534935689142776 | [962,709] | [119,126] | -8 | hSpCas9 | negative selection | 315430 | 18967841 | 18967864 | 14 | - | 26472758 | KBM7 | viability | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | -0.5731656493056612 | [2044,1677] | [665,512] | -5 | hSpCas9 | negative selection | 315440 | 18967629 | 18967652 | 14 | - | 26472758 | KBM7 | viability | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | 0.7735648851844872 | [981,744] | [683,690] | 8 | hSpCas9 | negative selection | 315441 | 18988308 | 18988331 | 14 | - | 26472758 | KBM7 | viability | CAGCAGTGGCACCGTTAGGCAGG | POTEM | ENSG00000222036 | 0.46181851934356877 | [572,472] | [364,311] | 5 | hSpCas9 | negative selection | 315443 | 18967859 | 18967882 | 14 | + | 26472758 | KBM7 | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | 0.33249529913958975 | [349,193] | [192,124] | 3 | hSpCas9 | negative selection | 315445 | 18967517 | 18967540 | 14 | - | 26472758 | KBM7 | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | -1.6128514843710589 | [894,734] | [121,126] | -8 | hSpCas9 | negative selection | 315448 | 18988322 | 18988345 | 14 | - | 26472758 | KBM7 | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -1.4801223273757618 | [725,951] | [180,110] | -8 | hSpCas9 | negative selection | 315451 | 18967536 | 18967559 | 14 | + | 26472758 | KBM7 | viability | ATTTGGTCTCAGAAGCAAGATGG | POTEM | ENSG00000222036 | 0.4829554474249492 | [287,361] | [186,243] | 5 | hSpCas9 | negative selection | 315454 | 18988354 | 18988377 | 14 | - | 26472758 | KBM7 | viability | GGTGTTCTGCTTTTCCTTGGTGG | POTEM | ENSG00000222036 | -1.229152032539454 | [821,552] | [148,123] | -7 | hSpCas9 | negative selection | 315457 | 18973026 | 18973049 | 14 | + | 26472758 | Raji | viability | ACTGACAGGCCGTACAATGCCAG | POTEM | ENSG00000222036 | 0.833587936159335 | [618] | [255] | 7 | hSpCas9 | negative selection | 506459 | 18988308 | 18988331 | 14 | - | 26472758 | Raji | viability | CAGCAGTGGCACCGTTAGGCAGG | POTEM | ENSG00000222036 | 0.44713290734820604 | [176] | [55] | 4 | hSpCas9 | negative selection | 506475 | 18967859 | 18967882 | 14 | + | 26472758 | Raji | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | 0.6767491810437369 | [123] | [45] | 6 | hSpCas9 | negative selection | 506476 | 18967517 | 18967540 | 14 | - | 26472758 | Raji | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | -0.9717351817440031 | [430] | [50] | -6 | hSpCas9 | negative selection | 506480 | 18988322 | 18988345 | 14 | - | 26472758 | Raji | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -1.2457632901244833 | [326] | [31] | -7 | hSpCas9 | negative selection | 506483 | 18967536 | 18967559 | 14 | + | 26472758 | Raji | viability | ATTTGGTCTCAGAAGCAAGATGG | POTEM | ENSG00000222036 | -0.35204808326369763 | [230] | [41] | -3 | hSpCas9 | negative selection | 506486 | 18988322 | 18988345 | 14 | - | 26472758 | Raji | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -1.2457632901244833 | [326] | [31] | -7 | hSpCas9 | negative selection | 506491 | 18967859 | 18967882 | 14 | + | 26472758 | Raji | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | 0.6767491810437369 | [123] | [45] | 6 | hSpCas9 | negative selection | 506502 | 18967517 | 18967540 | 14 | - | 26472758 | Raji | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | -0.9717351817440031 | [430] | [50] | -6 | hSpCas9 | negative selection | 506505 | 18967751 | 18967774 | 14 | - | 26472758 | Raji | viability | GCTCCTGAGTGTCTTCATAGCAG | POTEM | ENSG00000222036 | 0.2756992839542549 | [597] | [167] | 2 | hSpCas9 | negative selection | 506525 | 18967640 | 18967663 | 14 | - | 26472758 | Raji | viability | GCTCCTGAGTGTCTTCATAGCAG | POTEM | ENSG00000222036 | 0.2756992839542549 | [597] | [167] | 2 | hSpCas9 | negative selection | 506529 | 18967823 | 18967846 | 14 | + | 26472758 | Raji | viability | GCAAGAGCAAAGTGGGCCCCTGG | POTEM | ENSG00000222036 | 1.5571864528131198 | [163] | [111] | 9 | hSpCas9 | negative selection | 506547 | 18985460 | 18985483 | 14 | + | 26472758 | Raji | viability | AAGTGAAAATAGCCAGCCAGAGG | POTEM | ENSG00000222036 | -1.2559149939336234 | [565] | [54] | -7 | hSpCas9 | negative selection | 506548 | 18967841 | 18967864 | 14 | - | 26472758 | Raji | viability | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | 0.6664674042691503 | [599] | [220] | 6 | hSpCas9 | negative selection | 506558 | 18967629 | 18967652 | 14 | - | 26472758 | Raji | viability | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | 0.488998033114993 | [392] | [127] | 4 | hSpCas9 | negative selection | 506559 | 18988308 | 18988331 | 14 | - | 26472758 | Raji | viability | CAGCAGTGGCACCGTTAGGCAGG | POTEM | ENSG00000222036 | 0.44713290734820604 | [176] | [55] | 4 | hSpCas9 | negative selection | 506561 | 18967859 | 18967882 | 14 | + | 26472758 | Raji | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | 0.6767491810437369 | [123] | [45] | 6 | hSpCas9 | negative selection | 506563 | 18967517 | 18967540 | 14 | - | 26472758 | Raji | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | -0.9717351817440031 | [430] | [50] | -6 | hSpCas9 | negative selection | 506566 | 18988322 | 18988345 | 14 | - | 26472758 | Raji | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -1.2457632901244833 | [326] | [31] | -7 | hSpCas9 | negative selection | 506569 | 18967536 | 18967559 | 14 | + | 26472758 | Raji | viability | ATTTGGTCTCAGAAGCAAGATGG | POTEM | ENSG00000222036 | -0.35204808326369763 | [230] | [41] | -3 | hSpCas9 | negative selection | 506572 | 18988354 | 18988377 | 14 | - | 26472758 | Raji | viability | GGTGTTCTGCTTTTCCTTGGTGG | POTEM | ENSG00000222036 | -1.0319747497728633 | [466] | [52] | -6 | hSpCas9 | negative selection | 506575 | 18973026 | 18973049 | 14 | + | 26472758 | K562 | viability | ACTGACAGGCCGTACAATGCCAG | POTEM | ENSG00000222036 | 0.10924817227688521 | [1173] | [1068] | 0 | hSpCas9 | negative selection | 697577 | 18988308 | 18988331 | 14 | - | 26472758 | K562 | viability | CAGCAGTGGCACCGTTAGGCAGG | POTEM | ENSG00000222036 | 0.8602752363333868 | [384] | [589] | 7 | hSpCas9 | negative selection | 697593 | 18967859 | 18967882 | 14 | + | 26472758 | K562 | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | 0.6445982682181775 | [121] | [160] | 5 | hSpCas9 | negative selection | 697594 | 18967517 | 18967540 | 14 | - | 26472758 | K562 | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | -1.0356891915262885 | [594] | [244] | -5 | hSpCas9 | negative selection | 697598 | 18988322 | 18988345 | 14 | - | 26472758 | K562 | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -2.9304301524151506 | [586] | [64] | -8 | hSpCas9 | negative selection | 697601 | 18967536 | 18967559 | 14 | + | 26472758 | K562 | viability | ATTTGGTCTCAGAAGCAAGATGG | POTEM | ENSG00000222036 | 0.047908940633173025 | [266] | [232] | 0 | hSpCas9 | negative selection | 697604 | 18988322 | 18988345 | 14 | - | 26472758 | K562 | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -2.9304301524151506 | [586] | [64] | -8 | hSpCas9 | negative selection | 697609 | 18967859 | 18967882 | 14 | + | 26472758 | K562 | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | 0.6445982682181775 | [121] | [160] | 5 | hSpCas9 | negative selection | 697620 | 18967517 | 18967540 | 14 | - | 26472758 | K562 | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | -1.0356891915262885 | [594] | [244] | -5 | hSpCas9 | negative selection | 697623 | 18967751 | 18967774 | 14 | - | 26472758 | K562 | viability | GCTCCTGAGTGTCTTCATAGCAG | POTEM | ENSG00000222036 | -0.38228107572516534 | [1279] | [828] | -3 | hSpCas9 | negative selection | 697643 | 18967640 | 18967663 | 14 | - | 26472758 | K562 | viability | GCTCCTGAGTGTCTTCATAGCAG | POTEM | ENSG00000222036 | -0.38228107572516534 | [1279] | [828] | -3 | hSpCas9 | negative selection | 697647 | 18967823 | 18967846 | 14 | + | 26472758 | K562 | viability | GCAAGAGCAAAGTGGGCCCCTGG | POTEM | ENSG00000222036 | 1.249655376032594 | [274] | [551] | 9 | hSpCas9 | negative selection | 697665 | 18985460 | 18985483 | 14 | + | 26472758 | K562 | viability | AAGTGAAAATAGCCAGCCAGAGG | POTEM | ENSG00000222036 | -3.315008680947572 | [671] | [56] | -8 | hSpCas9 | negative selection | 697666 | 18967841 | 18967864 | 14 | - | 26472758 | K562 | viability | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | -0.7580411110213574 | [1173] | [585] | -4 | hSpCas9 | negative selection | 697676 | 18967629 | 18967652 | 14 | - | 26472758 | K562 | viability | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | 0.25682374855722745 | [578] | [583] | 2 | hSpCas9 | negative selection | 697677 | 18988308 | 18988331 | 14 | - | 26472758 | K562 | viability | CAGCAGTGGCACCGTTAGGCAGG | POTEM | ENSG00000222036 | 0.8602752363333868 | [384] | [589] | 7 | hSpCas9 | negative selection | 697679 | 18967859 | 18967882 | 14 | + | 26472758 | K562 | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | 0.6445982682181775 | [121] | [160] | 5 | hSpCas9 | negative selection | 697681 | 18967517 | 18967540 | 14 | - | 26472758 | K562 | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | -1.0356891915262885 | [594] | [244] | -5 | hSpCas9 | negative selection | 697684 | 18988322 | 18988345 | 14 | - | 26472758 | K562 | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -2.9304301524151506 | [586] | [64] | -8 | hSpCas9 | negative selection | 697687 | 18967536 | 18967559 | 14 | + | 26472758 | K562 | viability | ATTTGGTCTCAGAAGCAAGATGG | POTEM | ENSG00000222036 | 0.047908940633173025 | [266] | [232] | 0 | hSpCas9 | negative selection | 697690 | 18988354 | 18988377 | 14 | - | 26472758 | K562 | viability | GGTGTTCTGCTTTTCCTTGGTGG | POTEM | ENSG00000222036 | -1.1203994161246618 | [733] | [284] | -6 | hSpCas9 | negative selection | 697693 | 18970100 | 18970123 | 14 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TCTCACTCTGTCACCCATGCCGG | POTEM | ENSG00000222036 | -1.0563295009396656 | [70,78] | [6,7] | -6 | dCas9-VP64 | positive selection | 2387710 | 18970100 | 18970123 | 14 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TCTCACTCTGTCACCCATGCCGG | POTEM | ENSG00000222036 | 3.1967559695878185 | [163,108] | [786,59] | 9 | dCas9-VP64 | positive selection | 2482965 | 18967841 | 18967864 | 14 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | -0.6822484140059804 | [3,3] | [1,1] | -8 | hSpCas9 | positive selection | 3012682 | 18967629 | 18967652 | 14 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | -0.19003570322963745 | [3,3] | [3,1] | -3 | hSpCas9 | positive selection | 3012683 | 18967839 | 18967862 | 14 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | TGTCGTCGTAGTCTCCCCAGGGG | POTEM | ENSG00000222036 | 0.3250583218437853 | [3,3] | [3,3] | 7 | hSpCas9 | positive selection | 3012684 | 18967841 | 18967864 | 14 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | -0.32626554984076456 | [3,3] | [2,0] | -5 | hSpCas9 | positive selection | 3080540 | 18967629 | 18967652 | 14 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | -0.4309619420470725 | [3,3] | [3,0] | -6 | hSpCas9 | positive selection | 3080541 | 18967839 | 18967862 | 14 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | TGTCGTCGTAGTCTCCCCAGGGG | POTEM | ENSG00000222036 | -0.1586397497332181 | [3,3] | [1,1] | -2 | hSpCas9 | positive selection | 3080542 | 18967841 | 18967864 | 14 | - | 26780180 | HT29 | viability (Avana library 4 designs) | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | 0.689856642185993 | [] | [] | 2 | hSpCas9 | negative selection | 3450823 | 18967890 | 18967913 | 14 | - | 26780180 | HT29 | viability (Avana library 4 designs) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | 4.21644815214158 | [] | [] | 9 | hSpCas9 | negative selection | 3450824 | 18967890 | 18967913 | 14 | - | 26780180 | HT29 | viability (Avana library 4 designs) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | 4.21644815214158 | [] | [] | 9 | hSpCas9 | negative selection | 3450825 | 18967890 | 18967913 | 14 | - | 26780180 | HT29 | viability (Avana library 4 designs) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | 4.21644815214158 | [] | [] | 9 | hSpCas9 | negative selection | 3450826 | 18973119 | 18973142 | 14 | - | 26780180 | HT29 | viability (Avana library 4 designs) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | 2.87540525143692 | [] | [] | 8 | hSpCas9 | negative selection | 3450827 | 18973119 | 18973142 | 14 | - | 26780180 | HT29 | viability (Avana library 4 designs) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | 2.87540525143692 | [] | [] | 8 | hSpCas9 | negative selection | 3450828 | 18973119 | 18973142 | 14 | - | 26780180 | HT29 | viability (Avana library 4 designs) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | 2.87540525143692 | [] | [] | 8 | hSpCas9 | negative selection | 3450829 | 18967629 | 18967652 | 14 | - | 26780180 | HT29 | viability (Avana library 4 designs) | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | -0.245448490824721 | [] | [] | -4 | hSpCas9 | negative selection | 3450830 | 18967839 | 18967862 | 14 | - | 26780180 | HT29 | viability (Avana library 4 designs) | TGTCGTCGTAGTCTCCCCAGGGG | POTEM | ENSG00000222036 | 1.53809727455705 | [] | [] | 6 | hSpCas9 | negative selection | 3450831 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -27.6996045319167 | [] | [] | -9 | hSpCas9 | negative selection | 3546314 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -27.6996045319167 | [] | [] | -9 | hSpCas9 | negative selection | 3546315 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -27.6996045319167 | [] | [] | -9 | hSpCas9 | negative selection | 3546316 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -25.5323701253257 | [] | [] | -9 | hSpCas9 | negative selection | 3546317 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -25.5323701253257 | [] | [] | -9 | hSpCas9 | negative selection | 3546318 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -25.5323701253257 | [] | [] | -9 | hSpCas9 | negative selection | 3546319 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -26.0891030094844 | [] | [] | -9 | hSpCas9 | negative selection | 3546320 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -26.0891030094844 | [] | [] | -9 | hSpCas9 | negative selection | 3546321 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -26.0891030094844 | [] | [] | -9 | hSpCas9 | negative selection | 3546322 | 18967839 | 18967862 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | TGTCGTCGTAGTCTCCCCAGGGG | POTEM | ENSG00000222036 | 4.31865485331774 | [] | [] | 7 | hSpCas9 | negative selection | 3546323 | 18967841 | 18967864 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | 6.44185084295306 | [] | [] | 9 | hSpCas9 | negative selection | 3546324 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -5.48422635249664 | [] | [] | -5 | hSpCas9 | negative selection | 3546325 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -5.48422635249664 | [] | [] | -5 | hSpCas9 | negative selection | 3546326 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -5.48422635249664 | [] | [] | -5 | hSpCas9 | negative selection | 3546327 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -4.62938125381703 | [] | [] | -5 | hSpCas9 | negative selection | 3546328 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -4.62938125381703 | [] | [] | -5 | hSpCas9 | negative selection | 3546329 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -4.62938125381703 | [] | [] | -5 | hSpCas9 | negative selection | 3546330 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -7.80660054686151 | [] | [] | -7 | hSpCas9 | negative selection | 3546331 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -7.80660054686151 | [] | [] | -7 | hSpCas9 | negative selection | 3546332 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -7.80660054686151 | [] | [] | -7 | hSpCas9 | negative selection | 3546333 | 18967629 | 18967652 | 14 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | -2.70856011049682 | [] | [] | -3 | hSpCas9 | negative selection | 3546334 | 18967476 | 18967499 | 14 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | TTAAAAGCAGATGGTGGCTGAGG | POTEM | ENSG00000222036 | -8.54395436339454 | [] | [] | -7 | hSpCas9 | negative selection | 3546335 | 18967476 | 18967499 | 14 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | TTAAAAGCAGATGGTGGCTGAGG | POTEM | ENSG00000222036 | -8.54395436339454 | [] | [] | -7 | hSpCas9 | negative selection | 3546336 | 18967476 | 18967499 | 14 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | TTAAAAGCAGATGGTGGCTGAGG | POTEM | ENSG00000222036 | -12.3602711383469 | [] | [] | -8 | hSpCas9 | negative selection | 3546337 | 18967476 | 18967499 | 14 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | TTAAAAGCAGATGGTGGCTGAGG | POTEM | ENSG00000222036 | -12.3602711383469 | [] | [] | -8 | hSpCas9 | negative selection | 3546338 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | 23.4360293434589 | [] | [] | 9 | hSpCas9 | negative selection | 3654973 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | 23.4360293434589 | [] | [] | 9 | hSpCas9 | negative selection | 3654974 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | 23.4360293434589 | [] | [] | 9 | hSpCas9 | negative selection | 3654975 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | 23.8154802276742 | [] | [] | 9 | hSpCas9 | negative selection | 3654976 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | 23.8154802276742 | [] | [] | 9 | hSpCas9 | negative selection | 3654977 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | 23.8154802276742 | [] | [] | 9 | hSpCas9 | negative selection | 3654978 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | 32.5426632425949 | [] | [] | 9 | hSpCas9 | negative selection | 3654979 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | 32.5426632425949 | [] | [] | 9 | hSpCas9 | negative selection | 3654980 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | 32.5426632425949 | [] | [] | 9 | hSpCas9 | negative selection | 3654981 | 18967839 | 18967862 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | TGTCGTCGTAGTCTCCCCAGGGG | POTEM | ENSG00000222036 | 9.80852733887083 | [] | [] | 6 | hSpCas9 | negative selection | 3654982 | 18967841 | 18967864 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | 8.7215469628005 | [] | [] | 6 | hSpCas9 | negative selection | 3654983 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | 11.3743807645826 | [] | [] | 7 | hSpCas9 | negative selection | 3654984 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | 11.3743807645826 | [] | [] | 7 | hSpCas9 | negative selection | 3654985 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | 11.3743807645826 | [] | [] | 7 | hSpCas9 | negative selection | 3654986 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | 11.5311504453971 | [] | [] | 7 | hSpCas9 | negative selection | 3654987 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | 11.5311504453971 | [] | [] | 7 | hSpCas9 | negative selection | 3654988 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | 11.5311504453971 | [] | [] | 7 | hSpCas9 | negative selection | 3654989 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | 24.4755937525173 | [] | [] | 9 | hSpCas9 | negative selection | 3654990 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | 24.4755937525173 | [] | [] | 9 | hSpCas9 | negative selection | 3654991 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | 24.4755937525173 | [] | [] | 9 | hSpCas9 | negative selection | 3654992 | 18967629 | 18967652 | 14 | - | 26780180 | A375 | viability (Avana lentiGuide) | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | -4.55924950940531 | [] | [] | -7 | hSpCas9 | negative selection | 3654993 | 18967476 | 18967499 | 14 | + | 26780180 | A375 | viability (Avana lentiGuide) | TTAAAAGCAGATGGTGGCTGAGG | POTEM | ENSG00000222036 | 21.274923055973 | [] | [] | 9 | hSpCas9 | negative selection | 3654994 | 18967476 | 18967499 | 14 | + | 26780180 | A375 | viability (Avana lentiGuide) | TTAAAAGCAGATGGTGGCTGAGG | POTEM | ENSG00000222036 | 21.274923055973 | [] | [] | 9 | hSpCas9 | negative selection | 3654995 | 18967476 | 18967499 | 14 | + | 26780180 | A375 | viability (Avana lentiGuide) | TTAAAAGCAGATGGTGGCTGAGG | POTEM | ENSG00000222036 | 25.2900675870124 | [] | [] | 9 | hSpCas9 | negative selection | 3654996 | 18967476 | 18967499 | 14 | + | 26780180 | A375 | viability (Avana lentiGuide) | TTAAAAGCAGATGGTGGCTGAGG | POTEM | ENSG00000222036 | 25.2900675870124 | [] | [] | 9 | hSpCas9 | negative selection | 3654997 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -1.5474678566402473 | [7] | [0,0] | -9 | hSpCas9 | positive selection | 3763632 | 18967839 | 18967862 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | TGTCGTCGTAGTCTCCCCAGGGG | POTEM | ENSG00000222036 | -1.5474678566402473 | [5] | [5,5] | -9 | hSpCas9 | positive selection | 3763633 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -1.5474678566402473 | [6] | [0,0] | -9 | hSpCas9 | positive selection | 3763634 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -1.5474678566402473 | [6] | [0,0] | -9 | hSpCas9 | positive selection | 3763635 | 18967841 | 18967864 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | -0.3386333087784699 | [3] | [4,4] | -5 | hSpCas9 | positive selection | 3763636 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -0.3386333087784699 | [7] | [4,3] | -5 | hSpCas9 | positive selection | 3763637 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -0.3386333087784699 | [8] | [6,5] | -5 | hSpCas9 | positive selection | 3763638 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -0.3386333087784699 | [7] | [4,4] | -5 | hSpCas9 | positive selection | 3763639 | 18967629 | 18967652 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | -0.023267262204046103 | [5] | [4,5] | 0 | hSpCas9 | positive selection | 3763640 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -2.838144155349256 | [7] | [0,0] | -9 | hSpCas9 | positive selection | 3763641 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -2.838144155349256 | [6] | [0,0] | -9 | hSpCas9 | positive selection | 3763642 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -2.838144155349256 | [6] | [0,0] | -9 | hSpCas9 | positive selection | 3763643 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -0.9920905390328751 | [7] | [0,0] | -8 | hSpCas9 | positive selection | 3763644 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -0.9920905390328751 | [7] | [4,3] | -8 | hSpCas9 | positive selection | 3763645 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -0.9920905390328751 | [6] | [0,0] | -8 | hSpCas9 | positive selection | 3763646 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -0.9920905390328751 | [6] | [0,0] | -8 | hSpCas9 | positive selection | 3763647 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -0.9920905390328751 | [8] | [6,5] | -8 | hSpCas9 | positive selection | 3763648 | 18967476 | 18967499 | 14 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | TTAAAAGCAGATGGTGGCTGAGG | POTEM | ENSG00000222036 | -0.9920905390328751 | [8] | [6,5] | -8 | hSpCas9 | positive selection | 3763649 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -0.9920905390328751 | [7] | [4,4] | -8 | hSpCas9 | positive selection | 3763650 | 18967476 | 18967499 | 14 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | TTAAAAGCAGATGGTGGCTGAGG | POTEM | ENSG00000222036 | -0.9920905390328751 | [6] | [3,3] | -8 | hSpCas9 | positive selection | 3763651 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -0.5023195628135939 | [7] | [4,3] | -6 | hSpCas9 | positive selection | 3763652 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -0.5023195628135939 | [8] | [6,5] | -6 | hSpCas9 | positive selection | 3763653 | 18967476 | 18967499 | 14 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | TTAAAAGCAGATGGTGGCTGAGG | POTEM | ENSG00000222036 | -0.5023195628135939 | [8] | [6,5] | -6 | hSpCas9 | positive selection | 3763654 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -0.5023195628135939 | [7] | [4,4] | -6 | hSpCas9 | positive selection | 3763655 | 18967476 | 18967499 | 14 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | TTAAAAGCAGATGGTGGCTGAGG | POTEM | ENSG00000222036 | -0.5023195628135939 | [6] | [3,3] | -6 | hSpCas9 | positive selection | 3763656 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -0.7197637790831672 | [8] | [2,4] | -7 | hSpCas9 | positive selection | 3872239 | 18967839 | 18967862 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | TGTCGTCGTAGTCTCCCCAGGGG | POTEM | ENSG00000222036 | -0.7197637790831672 | [5] | [2,3] | -7 | hSpCas9 | positive selection | 3872240 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -0.7197637790831672 | [7] | [3,3] | -7 | hSpCas9 | positive selection | 3872241 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -0.7197637790831672 | [7] | [1,3] | -7 | hSpCas9 | positive selection | 3872242 | 18967841 | 18967864 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | -0.606885981935348 | [5] | [2,0] | -6 | hSpCas9 | positive selection | 3872243 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -0.606885981935348 | [7] | [2,2] | -6 | hSpCas9 | positive selection | 3872244 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -0.606885981935348 | [7] | [5,5] | -6 | hSpCas9 | positive selection | 3872245 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -0.606885981935348 | [6] | [4,1] | -6 | hSpCas9 | positive selection | 3872246 | 18967629 | 18967652 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | -0.2835974857733736 | [5] | [1,4] | -4 | hSpCas9 | positive selection | 3872247 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -0.8129805626504812 | [8] | [2,4] | -7 | hSpCas9 | positive selection | 3872248 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -0.8129805626504812 | [7] | [3,3] | -7 | hSpCas9 | positive selection | 3872249 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -0.8129805626504812 | [7] | [1,3] | -7 | hSpCas9 | positive selection | 3872250 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -0.7109620471151924 | [8] | [2,4] | -7 | hSpCas9 | positive selection | 3872251 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -0.7109620471151924 | [7] | [2,2] | -7 | hSpCas9 | positive selection | 3872252 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -0.7109620471151924 | [7] | [3,3] | -7 | hSpCas9 | positive selection | 3872253 | 18967890 | 18967913 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GCTTGTCCAGATCTTCTCGACGG | POTEM | ENSG00000222036 | -0.7109620471151924 | [7] | [1,3] | -7 | hSpCas9 | positive selection | 3872254 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -0.7109620471151924 | [7] | [5,5] | -7 | hSpCas9 | positive selection | 3872255 | 18967476 | 18967499 | 14 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | TTAAAAGCAGATGGTGGCTGAGG | POTEM | ENSG00000222036 | -0.7109620471151924 | [8] | [4,4] | -7 | hSpCas9 | positive selection | 3872256 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -0.7109620471151924 | [6] | [4,1] | -7 | hSpCas9 | positive selection | 3872257 | 18967476 | 18967499 | 14 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | TTAAAAGCAGATGGTGGCTGAGG | POTEM | ENSG00000222036 | -0.7109620471151924 | [6] | [0,2] | -7 | hSpCas9 | positive selection | 3872258 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -0.6512152359860555 | [7] | [2,2] | -7 | hSpCas9 | positive selection | 3872259 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -0.6512152359860555 | [7] | [5,5] | -7 | hSpCas9 | positive selection | 3872260 | 18967476 | 18967499 | 14 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | TTAAAAGCAGATGGTGGCTGAGG | POTEM | ENSG00000222036 | -0.6512152359860555 | [8] | [4,4] | -7 | hSpCas9 | positive selection | 3872261 | 18973119 | 18973142 | 14 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GTAGATAGCATAGTGTAGAGCGG | POTEM | ENSG00000222036 | -0.6512152359860555 | [6] | [4,1] | -7 | hSpCas9 | positive selection | 3872262 | 18967476 | 18967499 | 14 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | TTAAAAGCAGATGGTGGCTGAGG | POTEM | ENSG00000222036 | -0.6512152359860555 | [6] | [0,2] | -7 | hSpCas9 | positive selection | 3872263 | 18973161 | 18973184 | 14 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -0.3957418880994978 | [6] | [3,3] | -7 | hSpCas9 | positive selection | 4355634 | 18967841 | 18967863 | 14 | - | 27760321 | OCIAML3 | viability | CTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | -0.23699681459987432 | [844,720] | [365,715] | -3 | hSpCas9 | negative selection | 4429491 | 18967841 | 18967863 | 14 | - | 27760321 | OCIAML2 | viability | CTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | -0.8243987598986803 | [844,720] | [296,434] | -7 | hSpCas9 | negative selection | 4512954 | 18967841 | 18967863 | 14 | - | 27760321 | MV411 | viability | CTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | 0.09793858487107876 | [844,720] | [573,516] | 0 | hSpCas9 | negative selection | 4596417 | 18967841 | 18967863 | 14 | - | 27760321 | HL60 | viability | CTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | -0.20371736533636964 | [844,720] | [589,514] | -2 | hSpCas9 | negative selection | 4679880 | 18967841 | 18967863 | 14 | - | 27760321 | HT1080 | viability | CTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | -2.5669090323412047 | [720,562] | [14,73] | -7 | hSpCas9 | negative selection | 4763343 | 18967841 | 18967863 | 14 | - | 27760321 | HT29 | viability after 7 days | CTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | -0.11528431943153916 | [720,562] | [888,900,520] | -2 | hSpCas9 | negative selection | 4846806 | 18967841 | 18967863 | 14 | - | 27760321 | HT29 | viability after 25 days | CTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | -2.0296466732642218 | [720,562] | [186,79,281] | -8 | hSpCas9 | negative selection | 4930269 | 18967841 | 18967863 | 14 | - | 27760321 | HT29 | viability after 22 days | CTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | -1.8701972612985853 | [720,562] | [107,260,242] | -8 | hSpCas9 | negative selection | 5013732 | 18967841 | 18967863 | 14 | - | 27760321 | HT29 | viability after 19 days | CTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | -1.8565874626915022 | [720,562] | [206,290,113] | -8 | hSpCas9 | negative selection | 5097195 | 18967841 | 18967863 | 14 | - | 27760321 | HT29 | viability after 16 days | CTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | -1.8585450823650052 | [720,562] | [160,185,243] | -8 | hSpCas9 | negative selection | 5180658 | 18967841 | 18967863 | 14 | - | 27760321 | HT29 | viability after 13 days | CTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | -1.0176477259498977 | [720,562] | [368,305,424] | -7 | hSpCas9 | negative selection | 5264121 | 18967841 | 18967863 | 14 | - | 27760321 | HT29 | viability after 10 days | CTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | -1.0105679300943349 | [720,562] | [345,429,417] | -8 | hSpCas9 | negative selection | 5347584 | 18967841 | 18967863 | 14 | - | 27760321 | MOLM13 | viability | CTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | -1.924305389029937 | [844,720] | [61,161] | -8 | hSpCas9 | negative selection | 5431047 | 18973161 | 18973184 | 14 | - | 27260156 | BXPC3 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -1.4651032926868799 | [5123] | [1592,1986,2009,2230] | -9 | hSpCas9 | negative selection | 5628094 | 18973161 | 18973184 | 14 | - | 27260156 | A673 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -0.9743473071204689 | [5123] | [3606,2844,3059,3066] | -9 | hSpCas9 | negative selection | 5749345 | 18973161 | 18973184 | 14 | - | 27260156 | A375 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -2.011382575758901 | [5123] | [1304,1832,1595,1270] | -9 | hSpCas9 | negative selection | 5870596 | 18973161 | 18973184 | 14 | - | 27260156 | COLO741 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -1.281072567897473 | [5123] | [3023,2701,2399] | -9 | hSpCas9 | negative selection | 5991847 | 18973161 | 18973184 | 14 | - | 27260156 | CAL120 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -1.6606479418393036 | [5123] | [2035,1808,2203] | -9 | hSpCas9 | negative selection | 6113098 | 18973161 | 18973184 | 14 | - | 27260156 | CADOES1 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -1.4680196608296894 | [5123] | [1848,1422,1835,1783] | -9 | hSpCas9 | negative selection | 6234349 | 18973161 | 18973184 | 14 | - | 27260156 | EWS502 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -2.3551394847844445 | [5123] | [864,1021,1139,1251] | -9 | hSpCas9 | negative selection | 6355600 | 18973161 | 18973184 | 14 | - | 27260156 | EW8 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -1.4472375830806434 | [5123] | [1871,1525,1224,1552] | -9 | hSpCas9 | negative selection | 6476851 | 18973161 | 18973184 | 14 | - | 27260156 | CORL105 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -1.4576007340746688 | [5123] | [1984,1939,2548,2315] | -9 | hSpCas9 | negative selection | 6598102 | 18973161 | 18973184 | 14 | - | 27260156 | HS294T | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -1.6306022909034164 | [5123] | [340,403,976,918] | -9 | hSpCas9 | negative selection | 6719353 | 18973161 | 18973184 | 14 | - | 27260156 | HCC44 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -2.3755752454595163 | [5123] | [766,1329,1165,1139] | -9 | hSpCas9 | negative selection | 6840604 | 18973161 | 18973184 | 14 | - | 27260156 | G402 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -2.137678297313782 | [5123] | [2248,1487,1083,1000] | -9 | hSpCas9 | negative selection | 6961855 | 18973161 | 18973184 | 14 | - | 27260156 | L33 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -0.8287049097049777 | [5123] | [2870,1192,1666,3101] | -9 | hSpCas9 | negative selection | 7083106 | 18973161 | 18973184 | 14 | - | 27260156 | K562 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -2.366236471694178 | [5123] | [887,920,1028,708] | -9 | hSpCas9 | negative selection | 7204357 | 18973161 | 18973184 | 14 | - | 27260156 | HT29 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -2.368362521102985 | [5123] | [1398,1326,1020,1106] | -9 | hSpCas9 | negative selection | 7325608 | 18973161 | 18973184 | 14 | - | 27260156 | MHHES1 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -1.2426337893487966 | [5123] | [2704,2511,2466,2127] | -9 | hSpCas9 | negative selection | 7446859 | 18973161 | 18973184 | 14 | - | 27260156 | MEWO | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -0.934529009709284 | [5123] | [2566,2590,2376] | -9 | hSpCas9 | negative selection | 7568110 | 18973161 | 18973184 | 14 | - | 27260156 | LNCAPCLONEFGC | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -1.723605519573063 | [5123] | [1553,1180,1541,1375] | -9 | hSpCas9 | negative selection | 7689361 | 18973161 | 18973184 | 14 | - | 27260156 | PANC0327 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -2.151897584626931 | [5123] | [1669,686,965,869] | -9 | hSpCas9 | negative selection | 7810612 | 18973161 | 18973184 | 14 | - | 27260156 | NCIH2009 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -2.6901901159631847 | [5123] | [1325,1091,950] | -9 | hSpCas9 | negative selection | 7931863 | 18973161 | 18973184 | 14 | - | 27260156 | NCIH1373 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -2.035064277763004 | [5123] | [1795,1505,1024,347] | -9 | hSpCas9 | negative selection | 8053114 | 18973161 | 18973184 | 14 | - | 27260156 | PATU8902 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -2.857926223014493 | [5123] | [710,1133,693,1535] | -9 | hSpCas9 | negative selection | 8174365 | 18973161 | 18973184 | 14 | - | 27260156 | PANC1 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -2.6749971632722493 | [5123] | [648,1072,527,589] | -9 | hSpCas9 | negative selection | 8295616 | 18973161 | 18973184 | 14 | - | 27260156 | PANC0813 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -2.0132099049603336 | [5123] | [1435,1660,1217,1631] | -9 | hSpCas9 | negative selection | 8416867 | 18973161 | 18973184 | 14 | - | 27260156 | RDES | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -1.8617723995137734 | [5123] | [1329,1443,1546,2295] | -9 | hSpCas9 | negative selection | 8538118 | 18973161 | 18973184 | 14 | - | 27260156 | PC3 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -0.7685469244920689 | [5123] | [1858,2957,4595,3431] | -9 | hSpCas9 | negative selection | 8659369 | 18973161 | 18973184 | 14 | - | 27260156 | PATU8988T | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -1.451409073494638 | [5123] | [1850,1429,1298,2704] | -9 | hSpCas9 | negative selection | 8780620 | 18973161 | 18973184 | 14 | - | 27260156 | T47D | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -1.416674504583645 | [5123] | [2323,2079,2170,2387] | -9 | hSpCas9 | negative selection | 8901871 | 18973161 | 18973184 | 14 | - | 27260156 | SU8686 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -2.406517632400206 | [5123] | [893,909,1107,925] | -9 | hSpCas9 | negative selection | 9023122 | 18973161 | 18973184 | 14 | - | 27260156 | SKES1 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -1.127714798247494 | [5123] | [2675,2833,2108,1877] | -9 | hSpCas9 | negative selection | 9144373 | 18973161 | 18973184 | 14 | - | 27260156 | TOV112D | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -0.8692114472620114 | [5123] | [2576,3970,2523,2437] | -9 | hSpCas9 | negative selection | 9265624 | 18973161 | 18973184 | 14 | - | 27260156 | TC71 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -0.7469157021900452 | [5123] | [3258,3256,3358,3209] | -9 | hSpCas9 | negative selection | 9386875 | 18973161 | 18973184 | 14 | - | 27260156 | TC32 | viability | ACCGTATAAGAGCAGTGCTTTGG | POTEM | ENSG00000222036 | -1.1847330797684439 | [5123] | [2012,1518,2721,2457] | -9 | hSpCas9 | negative selection | 9508126 | 18967823 | 18967846 | 14 | + | 28162770 | P31FUJ | viability | GCAAGAGCAAAGTGGGCCCCTGG | POTEM | ENSG00000222036 | 0.7746152671481042 | [193] | [389] | 8 | hSpCas9 | negative selection | 10214747 | 18985460 | 18985483 | 14 | + | 28162770 | P31FUJ | viability | AAGTGAAAATAGCCAGCCAGAGG | POTEM | ENSG00000222036 | -0.7339963474429372 | [459] | [324] | -5 | hSpCas9 | negative selection | 10214748 | 18967841 | 18967864 | 14 | - | 28162770 | P31FUJ | viability | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | 0.3180491502101852 | [698] | [1023] | 3 | hSpCas9 | negative selection | 10214749 | 18967629 | 18967652 | 14 | - | 28162770 | P31FUJ | viability | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | 0.28216509354852015 | [365] | [522] | 3 | hSpCas9 | negative selection | 10214750 | 18988308 | 18988331 | 14 | - | 28162770 | P31FUJ | viability | CAGCAGTGGCACCGTTAGGCAGG | POTEM | ENSG00000222036 | 0.15052643513712702 | [183] | [239] | 1 | hSpCas9 | negative selection | 10214751 | 18967859 | 18967882 | 14 | + | 28162770 | P31FUJ | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | 0.13916657297257928 | [118] | [153] | 1 | hSpCas9 | negative selection | 10214752 | 18967517 | 18967540 | 14 | - | 28162770 | P31FUJ | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | -0.49363570205490126 | [392] | [327] | -4 | hSpCas9 | negative selection | 10214753 | 18988322 | 18988345 | 14 | - | 28162770 | P31FUJ | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -0.2258993441596907 | [416] | [418] | -2 | hSpCas9 | negative selection | 10214754 | 18967536 | 18967559 | 14 | + | 28162770 | P31FUJ | viability | ATTTGGTCTCAGAAGCAAGATGG | POTEM | ENSG00000222036 | 0.16226059510319918 | [199] | [262] | 1 | hSpCas9 | negative selection | 10214755 | 18988354 | 18988377 | 14 | - | 28162770 | P31FUJ | viability | GGTGTTCTGCTTTTCCTTGGTGG | POTEM | ENSG00000222036 | 0.5444187482141948 | [310] | [532] | 6 | hSpCas9 | negative selection | 10214756 | 18967823 | 18967846 | 14 | + | 28162770 | TF1 | viability | GCAAGAGCAAAGTGGGCCCCTGG | POTEM | ENSG00000222036 | NaN | [NaN] | [338] | 1 | hSpCas9 | negative selection | 10384113 | 18985460 | 18985483 | 14 | + | 28162770 | TF1 | viability | AAGTGAAAATAGCCAGCCAGAGG | POTEM | ENSG00000222036 | NaN | [NaN] | [128] | 1 | hSpCas9 | negative selection | 10384114 | 18967841 | 18967864 | 14 | - | 28162770 | TF1 | viability | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | NaN | [NaN] | [940] | 1 | hSpCas9 | negative selection | 10384115 | 18967629 | 18967652 | 14 | - | 28162770 | TF1 | viability | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | NaN | [NaN] | [487] | 1 | hSpCas9 | negative selection | 10384116 | 18988308 | 18988331 | 14 | - | 28162770 | TF1 | viability | CAGCAGTGGCACCGTTAGGCAGG | POTEM | ENSG00000222036 | NaN | [NaN] | [163] | 1 | hSpCas9 | negative selection | 10384117 | 18967859 | 18967882 | 14 | + | 28162770 | TF1 | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | NaN | [NaN] | [146] | 1 | hSpCas9 | negative selection | 10384118 | 18967517 | 18967540 | 14 | - | 28162770 | TF1 | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | NaN | [NaN] | [248] | 1 | hSpCas9 | negative selection | 10384119 | 18988322 | 18988345 | 14 | - | 28162770 | TF1 | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | NaN | [NaN] | [243] | 1 | hSpCas9 | negative selection | 10384120 | 18967536 | 18967559 | 14 | + | 28162770 | TF1 | viability | ATTTGGTCTCAGAAGCAAGATGG | POTEM | ENSG00000222036 | NaN | [NaN] | [191] | 1 | hSpCas9 | negative selection | 10384121 | 18988354 | 18988377 | 14 | - | 28162770 | TF1 | viability | GGTGTTCTGCTTTTCCTTGGTGG | POTEM | ENSG00000222036 | NaN | [NaN] | [153] | 1 | hSpCas9 | negative selection | 10384122 | 18967823 | 18967846 | 14 | + | 28162770 | SKM1 | viability | GCAAGAGCAAAGTGGGCCCCTGG | POTEM | ENSG00000222036 | 0.6667454874398475 | [61] | [173] | 6 | hSpCas9 | negative selection | 10553479 | 18985460 | 18985483 | 14 | + | 28162770 | SKM1 | viability | AAGTGAAAATAGCCAGCCAGAGG | POTEM | ENSG00000222036 | -0.14392979290936792 | [99] | [159] | -1 | hSpCas9 | negative selection | 10553480 | 18967841 | 18967864 | 14 | - | 28162770 | SKM1 | viability | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | 0.40139085856481826 | [205] | [480] | 4 | hSpCas9 | negative selection | 10553481 | 18967629 | 18967652 | 14 | - | 28162770 | SKM1 | viability | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | 0.42735777091471183 | [105] | [251] | 4 | hSpCas9 | negative selection | 10553482 | 18988308 | 18988331 | 14 | - | 28162770 | SKM1 | viability | CAGCAGTGGCACCGTTAGGCAGG | POTEM | ENSG00000222036 | -0.27451390271951237 | [51] | [75] | -2 | hSpCas9 | negative selection | 10553483 | 18967859 | 18967882 | 14 | + | 28162770 | SKM1 | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | -0.0850361038557993 | [38] | [64] | 0 | hSpCas9 | negative selection | 10553484 | 18967517 | 18967540 | 14 | - | 28162770 | SKM1 | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | -0.0009718390673250088 | [89] | [158] | 0 | hSpCas9 | negative selection | 10553485 | 18988322 | 18988345 | 14 | - | 28162770 | SKM1 | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -0.18125141911510245 | [92] | [144] | -1 | hSpCas9 | negative selection | 10553486 | 18967536 | 18967559 | 14 | + | 28162770 | SKM1 | viability | ATTTGGTCTCAGAAGCAAGATGG | POTEM | ENSG00000222036 | 1.203533394085132 | [41] | [170] | 9 | hSpCas9 | negative selection | 10553487 | 18988354 | 18988377 | 14 | - | 28162770 | SKM1 | viability | GGTGTTCTGCTTTTCCTTGGTGG | POTEM | ENSG00000222036 | -1.0294437778924819 | [111] | [96] | -6 | hSpCas9 | negative selection | 10553488 | 18967823 | 18967846 | 14 | + | 28162770 | SKM1 | viability | GCAAGAGCAAAGTGGGCCCCTGG | POTEM | ENSG00000222036 | 0.6667454874398475 | [61] | [173] | 6 | hSpCas9 | negative selection | 10722845 | 18985460 | 18985483 | 14 | + | 28162770 | SKM1 | viability | AAGTGAAAATAGCCAGCCAGAGG | POTEM | ENSG00000222036 | -0.14392979290936792 | [99] | [159] | -1 | hSpCas9 | negative selection | 10722846 | 18967841 | 18967864 | 14 | - | 28162770 | SKM1 | viability | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | 0.40139085856481826 | [205] | [480] | 4 | hSpCas9 | negative selection | 10722847 | 18967629 | 18967652 | 14 | - | 28162770 | SKM1 | viability | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | 0.42735777091471183 | [105] | [251] | 4 | hSpCas9 | negative selection | 10722848 | 18988308 | 18988331 | 14 | - | 28162770 | SKM1 | viability | CAGCAGTGGCACCGTTAGGCAGG | POTEM | ENSG00000222036 | -0.27451390271951237 | [51] | [75] | -2 | hSpCas9 | negative selection | 10722849 | 18967859 | 18967882 | 14 | + | 28162770 | SKM1 | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | -0.0850361038557993 | [38] | [64] | 0 | hSpCas9 | negative selection | 10722850 | 18967517 | 18967540 | 14 | - | 28162770 | SKM1 | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | -0.0009718390673250088 | [89] | [158] | 0 | hSpCas9 | negative selection | 10722851 | 18988322 | 18988345 | 14 | - | 28162770 | SKM1 | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -0.18125141911510245 | [92] | [144] | -1 | hSpCas9 | negative selection | 10722852 | 18967536 | 18967559 | 14 | + | 28162770 | SKM1 | viability | ATTTGGTCTCAGAAGCAAGATGG | POTEM | ENSG00000222036 | 1.203533394085132 | [41] | [170] | 9 | hSpCas9 | negative selection | 10722853 | 18988354 | 18988377 | 14 | - | 28162770 | SKM1 | viability | GGTGTTCTGCTTTTCCTTGGTGG | POTEM | ENSG00000222036 | -1.0294437778924819 | [111] | [96] | -6 | hSpCas9 | negative selection | 10722854 | 18967823 | 18967846 | 14 | + | 28162770 | PL21 | viability | GCAAGAGCAAAGTGGGCCCCTGG | POTEM | ENSG00000222036 | -1.115215826474556 | [218] | [43] | -6 | hSpCas9 | negative selection | 10892211 | 18985460 | 18985483 | 14 | + | 28162770 | PL21 | viability | AAGTGAAAATAGCCAGCCAGAGG | POTEM | ENSG00000222036 | -1.4266430619264632 | [419] | [67] | -7 | hSpCas9 | negative selection | 10892212 | 18967841 | 18967864 | 14 | - | 28162770 | PL21 | viability | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | 0.739235106453147 | [734] | [533] | 6 | hSpCas9 | negative selection | 10892213 | 18967629 | 18967652 | 14 | - | 28162770 | PL21 | viability | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | 0.09752454800643384 | [334] | [155] | 0 | hSpCas9 | negative selection | 10892214 | 18988308 | 18988331 | 14 | - | 28162770 | PL21 | viability | CAGCAGTGGCACCGTTAGGCAGG | POTEM | ENSG00000222036 | -0.8648158273514499 | [158] | [37] | -5 | hSpCas9 | negative selection | 10892215 | 18967859 | 18967882 | 14 | + | 28162770 | PL21 | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | -0.2958178801730913 | [109] | [38] | -2 | hSpCas9 | negative selection | 10892216 | 18967517 | 18967540 | 14 | - | 28162770 | PL21 | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | -0.6771778657358513 | [337] | [91] | -5 | hSpCas9 | negative selection | 10892217 | 18988322 | 18988345 | 14 | - | 28162770 | PL21 | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -0.514883426796209 | [347] | [105] | -4 | hSpCas9 | negative selection | 10892218 | 18967536 | 18967559 | 14 | + | 28162770 | PL21 | viability | ATTTGGTCTCAGAAGCAAGATGG | POTEM | ENSG00000222036 | -0.23672424724270236 | [110] | [40] | -2 | hSpCas9 | negative selection | 10892219 | 18988354 | 18988377 | 14 | - | 28162770 | PL21 | viability | GGTGTTCTGCTTTTCCTTGGTGG | POTEM | ENSG00000222036 | 0.1825097204675286 | [246] | [121] | 1 | hSpCas9 | negative selection | 10892220 | 18967823 | 18967846 | 14 | + | 28162770 | P31FUJ | viability | GCAAGAGCAAAGTGGGCCCCTGG | POTEM | ENSG00000222036 | 0.7746152671481042 | [193] | [389] | 8 | hSpCas9 | negative selection | 11061577 | 18985460 | 18985483 | 14 | + | 28162770 | P31FUJ | viability | AAGTGAAAATAGCCAGCCAGAGG | POTEM | ENSG00000222036 | -0.7339963474429372 | [459] | [324] | -5 | hSpCas9 | negative selection | 11061578 | 18967841 | 18967864 | 14 | - | 28162770 | P31FUJ | viability | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | 0.3180491502101852 | [698] | [1023] | 3 | hSpCas9 | negative selection | 11061579 | 18967629 | 18967652 | 14 | - | 28162770 | P31FUJ | viability | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | 0.28216509354852015 | [365] | [522] | 3 | hSpCas9 | negative selection | 11061580 | 18988308 | 18988331 | 14 | - | 28162770 | P31FUJ | viability | CAGCAGTGGCACCGTTAGGCAGG | POTEM | ENSG00000222036 | 0.15052643513712702 | [183] | [239] | 1 | hSpCas9 | negative selection | 11061581 | 18967859 | 18967882 | 14 | + | 28162770 | P31FUJ | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | 0.13916657297257928 | [118] | [153] | 1 | hSpCas9 | negative selection | 11061582 | 18967517 | 18967540 | 14 | - | 28162770 | P31FUJ | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | -0.49363570205490126 | [392] | [327] | -4 | hSpCas9 | negative selection | 11061583 | 18988322 | 18988345 | 14 | - | 28162770 | P31FUJ | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -0.2258993441596907 | [416] | [418] | -2 | hSpCas9 | negative selection | 11061584 | 18967536 | 18967559 | 14 | + | 28162770 | P31FUJ | viability | ATTTGGTCTCAGAAGCAAGATGG | POTEM | ENSG00000222036 | 0.16226059510319918 | [199] | [262] | 1 | hSpCas9 | negative selection | 11061585 | 18988354 | 18988377 | 14 | - | 28162770 | P31FUJ | viability | GGTGTTCTGCTTTTCCTTGGTGG | POTEM | ENSG00000222036 | 0.5444187482141948 | [310] | [532] | 6 | hSpCas9 | negative selection | 11061586 | 18967823 | 18967846 | 14 | + | 28162770 | OCIAML5 | viability | GCAAGAGCAAAGTGGGCCCCTGG | POTEM | ENSG00000222036 | 1.2701208681454916 | [98] | [430] | 9 | hSpCas9 | negative selection | 11230943 | 18985460 | 18985483 | 14 | + | 28162770 | OCIAML5 | viability | AAGTGAAAATAGCCAGCCAGAGG | POTEM | ENSG00000222036 | -1.801082642145192 | [277] | [143] | -7 | hSpCas9 | negative selection | 11230944 | 18967841 | 18967864 | 14 | - | 28162770 | OCIAML5 | viability | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | 0.27733190324888257 | [356] | [780] | 2 | hSpCas9 | negative selection | 11230945 | 18967629 | 18967652 | 14 | - | 28162770 | OCIAML5 | viability | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | 0.22810377781998636 | [244] | [517] | 2 | hSpCas9 | negative selection | 11230946 | 18988308 | 18988331 | 14 | - | 28162770 | OCIAML5 | viability | CAGCAGTGGCACCGTTAGGCAGG | POTEM | ENSG00000222036 | -0.1611706253937757 | [69] | [112] | -1 | hSpCas9 | negative selection | 11230947 | 18967859 | 18967882 | 14 | + | 28162770 | OCIAML5 | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | 0.8653462258808089 | [51] | [170] | 7 | hSpCas9 | negative selection | 11230948 | 18967517 | 18967540 | 14 | - | 28162770 | OCIAML5 | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | -1.2868673249642706 | [195] | [144] | -6 | hSpCas9 | negative selection | 11230949 | 18988322 | 18988345 | 14 | - | 28162770 | OCIAML5 | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -1.0843251453236773 | [268] | [228] | -6 | hSpCas9 | negative selection | 11230950 | 18967536 | 18967559 | 14 | + | 28162770 | OCIAML5 | viability | ATTTGGTCTCAGAAGCAAGATGG | POTEM | ENSG00000222036 | 0.15447627500277517 | [109] | [220] | 1 | hSpCas9 | negative selection | 11230951 | 18988354 | 18988377 | 14 | - | 28162770 | OCIAML5 | viability | GGTGTTCTGCTTTTCCTTGGTGG | POTEM | ENSG00000222036 | -1.564784618783526 | [176] | [107] | -7 | hSpCas9 | negative selection | 11230952 | 18967823 | 18967846 | 14 | + | 28162770 | EOL1 | viability | GCAAGAGCAAAGTGGGCCCCTGG | POTEM | ENSG00000222036 | 0.4559500275411631 | [374] | [270] | 4 | hSpCas9 | negative selection | 11400309 | 18985460 | 18985483 | 14 | + | 28162770 | EOL1 | viability | AAGTGAAAATAGCCAGCCAGAGG | POTEM | ENSG00000222036 | -2.1891090102250326 | [527] | [60] | -8 | hSpCas9 | negative selection | 11400310 | 18967841 | 18967864 | 14 | - | 28162770 | EOL1 | viability | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | 0.5319768663979239 | [1422] | [1083] | 5 | hSpCas9 | negative selection | 11400311 | 18967629 | 18967652 | 14 | - | 28162770 | EOL1 | viability | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | 0.45797997165160875 | [531] | [384] | 4 | hSpCas9 | negative selection | 11400312 | 18988308 | 18988331 | 14 | - | 28162770 | EOL1 | viability | CAGCAGTGGCACCGTTAGGCAGG | POTEM | ENSG00000222036 | 0.68715318689484 | [289] | [245] | 6 | hSpCas9 | negative selection | 11400313 | 18967859 | 18967882 | 14 | + | 28162770 | EOL1 | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | 0.21085195672717577 | [204] | [124] | 2 | hSpCas9 | negative selection | 11400314 | 18967517 | 18967540 | 14 | - | 28162770 | EOL1 | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | -0.643136737718786 | [414] | [139] | -5 | hSpCas9 | negative selection | 11400315 | 18988322 | 18988345 | 14 | - | 28162770 | EOL1 | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -1.0200132420040389 | [484] | [125] | -6 | hSpCas9 | negative selection | 11400316 | 18967536 | 18967559 | 14 | + | 28162770 | EOL1 | viability | ATTTGGTCTCAGAAGCAAGATGG | POTEM | ENSG00000222036 | 2.005975370914381 | [154] | [327] | 9 | hSpCas9 | negative selection | 11400317 | 18988354 | 18988377 | 14 | - | 28162770 | EOL1 | viability | GGTGTTCTGCTTTTCCTTGGTGG | POTEM | ENSG00000222036 | -0.3164603279332603 | [311] | [131] | -2 | hSpCas9 | negative selection | 11400318 | 18967823 | 18967846 | 14 | + | 28162770 | MOLM13 | viability | GCAAGAGCAAAGTGGGCCCCTGG | POTEM | ENSG00000222036 | 2.0690231729368804 | [206] | [627] | 9 | hSpCas9 | negative selection | 11569675 | 18985460 | 18985483 | 14 | + | 28162770 | MOLM13 | viability | AAGTGAAAATAGCCAGCCAGAGG | POTEM | ENSG00000222036 | -2.818991766243583 | [487] | [49] | -8 | hSpCas9 | negative selection | 11569676 | 18967841 | 18967864 | 14 | - | 28162770 | MOLM13 | viability | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | 0.8704359366402257 | [869] | [1149] | 6 | hSpCas9 | negative selection | 11569677 | 18967629 | 18967652 | 14 | - | 28162770 | MOLM13 | viability | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | 1.2372049425830092 | [537] | [916] | 8 | hSpCas9 | negative selection | 11569678 | 18988308 | 18988331 | 14 | - | 28162770 | MOLM13 | viability | CAGCAGTGGCACCGTTAGGCAGG | POTEM | ENSG00000222036 | 0.4678893815445787 | [240] | [240] | 3 | hSpCas9 | negative selection | 11569679 | 18967859 | 18967882 | 14 | + | 28162770 | MOLM13 | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | 1.6959173375504597 | [145] | [341] | 9 | hSpCas9 | negative selection | 11569680 | 18967517 | 18967540 | 14 | - | 28162770 | MOLM13 | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | -2.2690762126216275 | [379] | [56] | -8 | hSpCas9 | negative selection | 11569681 | 18988322 | 18988345 | 14 | - | 28162770 | MOLM13 | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -0.7749671423515847 | [709] | [299] | -4 | hSpCas9 | negative selection | 11569682 | 18967536 | 18967559 | 14 | + | 28162770 | MOLM13 | viability | ATTTGGTCTCAGAAGCAAGATGG | POTEM | ENSG00000222036 | -0.31568715491321725 | [345] | [200] | -2 | hSpCas9 | negative selection | 11569683 | 18988354 | 18988377 | 14 | - | 28162770 | MOLM13 | viability | GGTGTTCTGCTTTTCCTTGGTGG | POTEM | ENSG00000222036 | -1.9615034107113352 | [403] | [74] | -7 | hSpCas9 | negative selection | 11569684 | 18967823 | 18967846 | 14 | + | 28162770 | HEL | viability | GCAAGAGCAAAGTGGGCCCCTGG | POTEM | ENSG00000222036 | 0.8067145671114829 | [215] | [241] | 7 | hSpCas9 | negative selection | 11739041 | 18985460 | 18985483 | 14 | + | 28162770 | HEL | viability | AAGTGAAAATAGCCAGCCAGAGG | POTEM | ENSG00000222036 | -2.248885006954851 | [422] | [56] | -8 | hSpCas9 | negative selection | 11739042 | 18967841 | 18967864 | 14 | - | 28162770 | HEL | viability | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | 0.9849434512677586 | [974] | [1235] | 8 | hSpCas9 | negative selection | 11739043 | 18967629 | 18967652 | 14 | - | 28162770 | HEL | viability | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | 0.7432379079516058 | [498] | [534] | 6 | hSpCas9 | negative selection | 11739044 | 18988308 | 18988331 | 14 | - | 28162770 | HEL | viability | CAGCAGTGGCACCGTTAGGCAGG | POTEM | ENSG00000222036 | 1.460305558682021 | [180] | [318] | 9 | hSpCas9 | negative selection | 11739045 | 18967859 | 18967882 | 14 | + | 28162770 | HEL | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | 1.024373173011987 | [141] | [184] | 8 | hSpCas9 | negative selection | 11739046 | 18967517 | 18967540 | 14 | - | 28162770 | HEL | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | -1.3730284838579598 | [367] | [90] | -7 | hSpCas9 | negative selection | 11739047 | 18988322 | 18988345 | 14 | - | 28162770 | HEL | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -3.161582029967614 | [474] | [33] | -9 | hSpCas9 | negative selection | 11739048 | 18967536 | 18967559 | 14 | + | 28162770 | HEL | viability | ATTTGGTCTCAGAAGCAAGATGG | POTEM | ENSG00000222036 | 0.3180121037603213 | [257] | [205] | 2 | hSpCas9 | negative selection | 11739049 | 18988354 | 18988377 | 14 | - | 28162770 | HEL | viability | GGTGTTCTGCTTTTCCTTGGTGG | POTEM | ENSG00000222036 | -2.025639676908437 | [355] | [55] | -8 | hSpCas9 | negative selection | 11739050 | 18967823 | 18967846 | 14 | + | 28162770 | MV411 | viability | GCAAGAGCAAAGTGGGCCCCTGG | POTEM | ENSG00000222036 | 0.7704723023607296 | [237] | [341] | 7 | hSpCas9 | negative selection | 11908407 | 18985460 | 18985483 | 14 | + | 28162770 | MV411 | viability | AAGTGAAAATAGCCAGCCAGAGG | POTEM | ENSG00000222036 | -1.9078406746951357 | [342] | [76] | -8 | hSpCas9 | negative selection | 11908408 | 18967841 | 18967864 | 14 | - | 28162770 | MV411 | viability | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | 0.4899609272254579 | [731] | [865] | 4 | hSpCas9 | negative selection | 11908409 | 18967629 | 18967652 | 14 | - | 28162770 | MV411 | viability | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | 1.1348457244064145 | [332] | [615] | 8 | hSpCas9 | negative selection | 11908410 | 18988308 | 18988331 | 14 | - | 28162770 | MV411 | viability | CAGCAGTGGCACCGTTAGGCAGG | POTEM | ENSG00000222036 | 1.3665487626704507 | [121] | [264] | 9 | hSpCas9 | negative selection | 11908411 | 18967859 | 18967882 | 14 | + | 28162770 | MV411 | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | -0.22649363754963703 | [124] | [89] | -2 | hSpCas9 | negative selection | 11908412 | 18967517 | 18967540 | 14 | - | 28162770 | MV411 | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | -0.7245480730476281 | [254] | [129] | -5 | hSpCas9 | negative selection | 11908413 | 18988322 | 18988345 | 14 | - | 28162770 | MV411 | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -1.5727414116324123 | [338] | [95] | -7 | hSpCas9 | negative selection | 11908414 | 18967536 | 18967559 | 14 | + | 28162770 | MV411 | viability | ATTTGGTCTCAGAAGCAAGATGG | POTEM | ENSG00000222036 | 0.28467045698175053 | [152] | [156] | 2 | hSpCas9 | negative selection | 11908415 | 18988354 | 18988377 | 14 | - | 28162770 | MV411 | viability | GGTGTTCTGCTTTTCCTTGGTGG | POTEM | ENSG00000222036 | -0.045758825561270866 | [260] | [212] | 0 | hSpCas9 | negative selection | 11908416 | 18967823 | 18967846 | 14 | + | 28162770 | MONOMAC1 | viability | GCAAGAGCAAAGTGGGCCCCTGG | POTEM | ENSG00000222036 | 0.6977809162483897 | [127] | [237] | 6 | hSpCas9 | negative selection | 12077773 | 18985460 | 18985483 | 14 | + | 28162770 | MONOMAC1 | viability | AAGTGAAAATAGCCAGCCAGAGG | POTEM | ENSG00000222036 | -1.2723249743637908 | [235] | [111] | -7 | hSpCas9 | negative selection | 12077774 | 18967841 | 18967864 | 14 | - | 28162770 | MONOMAC1 | viability | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | 0.31606843175763855 | [589] | [841] | 3 | hSpCas9 | negative selection | 12077775 | 18967629 | 18967652 | 14 | - | 28162770 | MONOMAC1 | viability | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | 0.8823976204348514 | [211] | [447] | 7 | hSpCas9 | negative selection | 12077776 | 18988308 | 18988331 | 14 | - | 28162770 | MONOMAC1 | viability | CAGCAGTGGCACCGTTAGGCAGG | POTEM | ENSG00000222036 | -0.9981327786454753 | [114] | [65] | -7 | hSpCas9 | negative selection | 12077777 | 18967859 | 18967882 | 14 | + | 28162770 | MONOMAC1 | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | 0.4713416618492402 | [55] | [88] | 4 | hSpCas9 | negative selection | 12077778 | 18967517 | 18967540 | 14 | - | 28162770 | MONOMAC1 | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | -0.45627967373097345 | [151] | [126] | -4 | hSpCas9 | negative selection | 12077779 | 18988322 | 18988345 | 14 | - | 28162770 | MONOMAC1 | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -0.3421535549193637 | [208] | [188] | -3 | hSpCas9 | negative selection | 12077780 | 18967536 | 18967559 | 14 | + | 28162770 | MONOMAC1 | viability | ATTTGGTCTCAGAAGCAAGATGG | POTEM | ENSG00000222036 | 0.11416484123475026 | [107] | [133] | 1 | hSpCas9 | negative selection | 12077781 | 18988354 | 18988377 | 14 | - | 28162770 | MONOMAC1 | viability | GGTGTTCTGCTTTTCCTTGGTGG | POTEM | ENSG00000222036 | -1.8293050625590666 | [185] | [59] | -8 | hSpCas9 | negative selection | 12077782 | 18967823 | 18967846 | 14 | + | 28162770 | OCIAML2 | viability | GCAAGAGCAAAGTGGGCCCCTGG | POTEM | ENSG00000222036 | 0.5911463723445288 | [39] | [333] | 6 | hSpCas9 | negative selection | 12247139 | 18985460 | 18985483 | 14 | + | 28162770 | OCIAML2 | viability | AAGTGAAAATAGCCAGCCAGAGG | POTEM | ENSG00000222036 | -2.5580926664925006 | [67] | [63] | -8 | hSpCas9 | negative selection | 12247140 | 18967841 | 18967864 | 14 | - | 28162770 | OCIAML2 | viability | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | -0.04008295204144585 | [132] | [716] | 0 | hSpCas9 | negative selection | 12247141 | 18967629 | 18967652 | 14 | - | 28162770 | OCIAML2 | viability | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | 0.7248302683072886 | [55] | [512] | 7 | hSpCas9 | negative selection | 12247142 | 18988308 | 18988331 | 14 | - | 28162770 | OCIAML2 | viability | CAGCAGTGGCACCGTTAGGCAGG | POTEM | ENSG00000222036 | -0.18023730378790564 | [36] | [180] | -1 | hSpCas9 | negative selection | 12247143 | 18967859 | 18967882 | 14 | + | 28162770 | OCIAML2 | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | 0.8741986717552799 | [24] | [253] | 8 | hSpCas9 | negative selection | 12247144 | 18967517 | 18967540 | 14 | - | 28162770 | OCIAML2 | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | -1.0634544437362878 | [45] | [121] | -6 | hSpCas9 | negative selection | 12247145 | 18988322 | 18988345 | 14 | - | 28162770 | OCIAML2 | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -1.4578057848845776 | [55] | [112] | -7 | hSpCas9 | negative selection | 12247146 | 18967536 | 18967559 | 14 | + | 28162770 | OCIAML2 | viability | ATTTGGTCTCAGAAGCAAGATGG | POTEM | ENSG00000222036 | 1.2814426613142533 | [18] | [255] | 9 | hSpCas9 | negative selection | 12247147 | 18988354 | 18988377 | 14 | - | 28162770 | OCIAML2 | viability | GGTGTTCTGCTTTTCCTTGGTGG | POTEM | ENSG00000222036 | -0.5637392296336428 | [51] | [194] | -4 | hSpCas9 | negative selection | 12247148 | 18967823 | 18967846 | 14 | + | 28162770 | OCIAML3 | viability | GCAAGAGCAAAGTGGGCCCCTGG | POTEM | ENSG00000222036 | 0.7333543406138273 | [52] | [265] | 6 | hSpCas9 | negative selection | 12416505 | 18985460 | 18985483 | 14 | + | 28162770 | OCIAML3 | viability | AAGTGAAAATAGCCAGCCAGAGG | POTEM | ENSG00000222036 | -1.1013036474549955 | [112] | [158] | -7 | hSpCas9 | negative selection | 12416506 | 18967841 | 18967864 | 14 | - | 28162770 | OCIAML3 | viability | GCTGTCGTCGTAGTCTCCCCAGG | POTEM | ENSG00000222036 | 0.6054722553635283 | [203] | [936] | 5 | hSpCas9 | negative selection | 12416507 | 18967629 | 18967652 | 14 | - | 28162770 | OCIAML3 | viability | TCTTCATAGCAGAATCATCGTGG | POTEM | ENSG00000222036 | 0.49570648103069104 | [112] | [480] | 4 | hSpCas9 | negative selection | 12416508 | 18988308 | 18988331 | 14 | - | 28162770 | OCIAML3 | viability | CAGCAGTGGCACCGTTAGGCAGG | POTEM | ENSG00000222036 | 1.1221993936752455 | [41] | [275] | 8 | hSpCas9 | negative selection | 12416509 | 18967859 | 18967882 | 14 | + | 28162770 | OCIAML3 | viability | ACAGCGCTTTCATGGAGCCGAGG | POTEM | ENSG00000222036 | 1.3694664836507227 | [24] | [194] | 9 | hSpCas9 | negative selection | 12416510 | 18967517 | 18967540 | 14 | - | 28162770 | OCIAML3 | viability | AAATGGCTTCTTCACAGAGGAGG | POTEM | ENSG00000222036 | -0.24390887274563966 | [70] | [180] | -2 | hSpCas9 | negative selection | 12416511 | 18988322 | 18988345 | 14 | - | 28162770 | OCIAML3 | viability | ATCATCACCATTGTCAGCAGTGG | POTEM | ENSG00000222036 | -0.05657350968559283 | [71] | [208] | 0 | hSpCas9 | negative selection | 12416512 | 18967536 | 18967559 | 14 | + | 28162770 | OCIAML3 | viability | ATTTGGTCTCAGAAGCAAGATGG | POTEM | ENSG00000222036 | 0.4222941720049373 | [43] | [177] | 4 | hSpCas9 | negative selection | 12416513 | 18988354 | 18988377 | 14 | - | 28162770 | OCIAML3 | viability | GGTGTTCTGCTTTTCCTTGGTGG | POTEM | ENSG00000222036 | -0.44610894521184974 | [87] | [194] | -3 | hSpCas9 | negative selection | 12416514 |