Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:5573
• Symbol:PRKAR1A
• Description:protein kinase cAMP-dependent type I regulatory subunit alpha

DataSource: http://genomecrispr.dkfz.de/#!/results/PRKAR1A

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
68515416	68515439	17	-	26472758	Jiyoye	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	2.178759172541656	[69]	[238]	9	hSpCas9	negative selection	127353
68522866	68522889	17	+	26472758	Jiyoye	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	2.4071753815058727	[0]	[3]	9	hSpCas9	negative selection	127354
68515536	68515559	17	-	26472758	Jiyoye	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-0.27364713462279877	[209]	[130]	-2	hSpCas9	negative selection	127355
68522794	68522817	17	+	26472758	Jiyoye	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	2.0755538904146666	[55]	[177]	8	hSpCas9	negative selection	127356
68522878	68522901	17	+	26472758	Jiyoye	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	0.965985594371061	[166]	[245]	6	hSpCas9	negative selection	127357
68524934	68524957	17	+	26472758	Jiyoye	viability	TGTGATTGATCAAGGAGAGACGG	PRKAR1A	ENSG00000108946	0.9818695467732028	[46]	[69]	6	hSpCas9	negative selection	127358
68528962	68528985	17	-	26472758	Jiyoye	viability	ATAATGAAGAACTCATCCCCTGG	PRKAR1A	ENSG00000108946	-0.6174866727283956	[235]	[115]	-4	hSpCas9	negative selection	127359
68522849	68522872	17	+	26472758	Jiyoye	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	1.207405869130096	[57]	[100]	7	hSpCas9	negative selection	127360
68524056	68524079	17	+	26472758	Jiyoye	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	6.289818430867714	[0]	[58]	9	hSpCas9	negative selection	127361
68525766	68525789	17	+	26472758	Jiyoye	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	0.4822768367465922	[130]	[137]	3	hSpCas9	negative selection	127362
68515416	68515439	17	-	26472758	KBM7	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.08119311745600122	[942,894]	[436,476]	0	hSpCas9	negative selection	318471
68522866	68522889	17	+	26472758	KBM7	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	-0.8605116699002258	[11,39]	[13,0]	-6	hSpCas9	negative selection	318472
68515536	68515559	17	-	26472758	KBM7	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	0.12938887788647918	[610,552]	[284,311]	1	hSpCas9	negative selection	318473
68522794	68522817	17	+	26472758	KBM7	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.15121344487650795	[535,446]	[231,184]	-1	hSpCas9	negative selection	318474
68522878	68522901	17	+	26472758	KBM7	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	0.023611696146513816	[1100,814]	[384,513]	0	hSpCas9	negative selection	318475
68524934	68524957	17	+	26472758	KBM7	viability	TGTGATTGATCAAGGAGAGACGG	PRKAR1A	ENSG00000108946	0.11316987140554935	[141,147]	[59,86]	1	hSpCas9	negative selection	318476
68528962	68528985	17	-	26472758	KBM7	viability	ATAATGAAGAACTCATCCCCTGG	PRKAR1A	ENSG00000108946	-0.7160691123271234	[621,512]	[111,205]	-5	hSpCas9	negative selection	318477
68522849	68522872	17	+	26472758	KBM7	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	0.5226974150286094	[370,427]	[194,342]	5	hSpCas9	negative selection	318478
68524056	68524079	17	+	26472758	KBM7	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.6734034778576639	[131,105]	[75,99]	7	hSpCas9	negative selection	318479
68525766	68525789	17	+	26472758	KBM7	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	-0.2004992194691495	[551,633]	[291,203]	-2	hSpCas9	negative selection	318480
68515416	68515439	17	-	26472758	Raji	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.730469581209936	[360]	[138]	6	hSpCas9	negative selection	509589
68522866	68522889	17	+	26472758	Raji	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	1.3704179412073927	[4]	[2]	9	hSpCas9	negative selection	509590
68515536	68515559	17	-	26472758	Raji	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	1.1431842568014463	[198]	[101]	8	hSpCas9	negative selection	509591
68522794	68522817	17	+	26472758	Raji	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	0.25367297762425567	[252]	[69]	2	hSpCas9	negative selection	509592
68522878	68522901	17	+	26472758	Raji	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	0.9195235199965804	[343]	[150]	8	hSpCas9	negative selection	509593
68524934	68524957	17	+	26472758	Raji	viability	TGTGATTGATCAAGGAGAGACGG	PRKAR1A	ENSG00000108946	0.8305433300147753	[62]	[25]	7	hSpCas9	negative selection	509594
68528962	68528985	17	-	26472758	Raji	viability	ATAATGAAGAACTCATCCCCTGG	PRKAR1A	ENSG00000108946	0.7483024420687711	[235]	[91]	7	hSpCas9	negative selection	509595
68522849	68522872	17	+	26472758	Raji	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	0.2554821743627334	[147]	[40]	2	hSpCas9	negative selection	509596
68524056	68524079	17	+	26472758	Raji	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	-1.062541466068713	[143]	[15]	-7	hSpCas9	negative selection	509597
68525766	68525789	17	+	26472758	Raji	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	0.3601496057535662	[234]	[69]	3	hSpCas9	negative selection	509598
68515416	68515439	17	-	26472758	K562	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.5538151907451891	[739]	[916]	4	hSpCas9	negative selection	700707
68522866	68522889	17	+	26472758	K562	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	0.06384648202462628	[16]	[14]	0	hSpCas9	negative selection	700708
68515536	68515559	17	-	26472758	K562	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	0.059530093358485664	[423]	[372]	0	hSpCas9	negative selection	700709
68522794	68522817	17	+	26472758	K562	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.3872288403548389	[580]	[374]	-3	hSpCas9	negative selection	700710
68522878	68522901	17	+	26472758	K562	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	0.3741866026367764	[849]	[929]	3	hSpCas9	negative selection	700711
68524934	68524957	17	+	26472758	K562	viability	TGTGATTGATCAAGGAGAGACGG	PRKAR1A	ENSG00000108946	0.8554940687067343	[145]	[222]	7	hSpCas9	negative selection	700712
68528962	68528985	17	-	26472758	K562	viability	ATAATGAAGAACTCATCCCCTGG	PRKAR1A	ENSG00000108946	0.7995804508543614	[374]	[550]	6	hSpCas9	negative selection	700713
68522849	68522872	17	+	26472758	K562	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	0.9448584458075389	[287]	[467]	7	hSpCas9	negative selection	700714
68524056	68524079	17	+	26472758	K562	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.39548470185744333	[153]	[170]	3	hSpCas9	negative selection	700715
68525766	68525789	17	+	26472758	K562	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	1.1807288597861347	[520]	[996]	8	hSpCas9	negative selection	700716
68515411	68515434	17	+	26627737	DLD1	viability	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	-1.1844779922167026	[467]	[76,53,61]	-8	hSpCas9	negative selection	799516
68522843	68522866	17	-	26627737	DLD1	viability	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	0.40893163021613865	[804]	[296,366,338]	4	hSpCas9	negative selection	799517
68522878	68522901	17	+	26627737	DLD1	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-0.4213384690758497	[1431]	[351,472,203]	-4	hSpCas9	negative selection	799518
68528864	68528887	17	+	26627737	DLD1	viability	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	0.2875152969944824	[576]	[169,273,218]	3	hSpCas9	negative selection	799519
68528917	68528940	17	-	26627737	DLD1	viability	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	0.7385849250686882	[463]	[408,187,141]	7	hSpCas9	negative selection	799520
68530303	68530326	17	-	26627737	DLD1	viability	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	0.8318807126386871	[286]	[231,172,85]	7	hSpCas9	negative selection	799521
68515411	68515434	17	+	26627737	GBM cells	viability after 5 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	-1.725576990022108	[221]	[17,53]	-9	hSpCas9	negative selection	881831
68522843	68522866	17	-	26627737	GBM cells	viability after 5 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	-0.2258411561222612	[506]	[258,205]	-4	hSpCas9	negative selection	881832
68522878	68522901	17	+	26627737	GBM cells	viability after 5 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-1.7772651433939946	[456]	[80,61]	-9	hSpCas9	negative selection	881833
68528864	68528887	17	+	26627737	GBM cells	viability after 5 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	0.33920416609644116	[268]	[194,169]	5	hSpCas9	negative selection	881834
68528917	68528940	17	-	26627737	GBM cells	viability after 5 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	0.06321432713411967	[256]	[142,144]	1	hSpCas9	negative selection	881835
68530303	68530326	17	-	26627737	GBM cells	viability after 5 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	-0.5626662103301883	[251]	[128,53]	-7	hSpCas9	negative selection	881836
68515411	68515434	17	+	26627737	GBM cells	viability after 13 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	-1.3754370387090127	[221]	[73,23]	-9	hSpCas9	negative selection	964146
68522843	68522866	17	-	26627737	GBM cells	viability after 13 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	-0.5658923473594178	[506]	[267,118]	-6	hSpCas9	negative selection	964147
68522878	68522901	17	+	26627737	GBM cells	viability after 13 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-3.529163429900783	[456]	[10,29]	-9	hSpCas9	negative selection	964148
68528864	68528887	17	+	26627737	GBM cells	viability after 13 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	0.37428568476120877	[268]	[213,168]	5	hSpCas9	negative selection	964149
68528917	68528940	17	-	26627737	GBM cells	viability after 13 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	-0.4995323801510043	[256]	[48,138]	-5	hSpCas9	negative selection	964150
68530303	68530326	17	-	26627737	GBM cells	viability after 13 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	-1.0560964804594835	[251]	[62,67]	-8	hSpCas9	negative selection	964151
68515411	68515434	17	+	26627737	GBM cells	viability after 21 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	-1.2054435253748683	[221]	[56,47]	-7	hSpCas9	negative selection	1046461
68522843	68522866	17	-	26627737	GBM cells	viability after 21 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	-0.7601294650701734	[506]	[182,143]	-6	hSpCas9	negative selection	1046462
68522878	68522901	17	+	26627737	GBM cells	viability after 21 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-3.150753944892797	[456]	[28,26]	-9	hSpCas9	negative selection	1046463
68528864	68528887	17	+	26627737	GBM cells	viability after 21 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	0.5437063134923418	[268]	[223,202]	5	hSpCas9	negative selection	1046464
68528917	68528940	17	-	26627737	GBM cells	viability after 21 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	0.20113810913326083	[256]	[171,149]	2	hSpCas9	negative selection	1046465
68530303	68530326	17	-	26627737	GBM cells	viability after 21 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	-0.7416465818930926	[251]	[72,89]	-6	hSpCas9	negative selection	1046466
68515411	68515434	17	+	26627737	RPE1	viability after 9 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	-1.7573197232155262	[1093]	[37,182]	-8	hSpCas9	negative selection	1128776
68522843	68522866	17	-	26627737	RPE1	viability after 9 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	-1.2979521798037876	[2240]	[235,348]	-7	hSpCas9	negative selection	1128777
68522878	68522901	17	+	26627737	RPE1	viability after 9 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	0.21433404114501758	[504]	[175,192]	1	hSpCas9	negative selection	1128778
68528864	68528887	17	+	26627737	RPE1	viability after 9 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	-0.17670994209405083	[1087]	[289,315]	-1	hSpCas9	negative selection	1128779
68528917	68528940	17	-	26627737	RPE1	viability after 9 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	-1.8634201558007217	[1277]	[119,96]	-8	hSpCas9	negative selection	1128780
68530303	68530326	17	-	26627737	RPE1	viability after 9 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	6.154448708194654	[2]	[48,89]	9	hSpCas9	negative selection	1128781
68515411	68515434	17	+	26627737	RPE1	viability after 12 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	-1.9513580976758331	[1093]	[75,75]	-8	hSpCas9	negative selection	1211091
68522843	68522866	17	-	26627737	RPE1	viability after 12 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	-0.8342781842987178	[2240]	[292,384]	-5	hSpCas9	negative selection	1211092
68522878	68522901	17	+	26627737	RPE1	viability after 12 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-0.269331268567247	[504]	[80,145]	-2	hSpCas9	negative selection	1211093
68528864	68528887	17	+	26627737	RPE1	viability after 12 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	-0.04262065040401247	[1087]	[276,290]	0	hSpCas9	negative selection	1211094
68528917	68528940	17	-	26627737	RPE1	viability after 12 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	-1.5339481050971737	[1277]	[120,115]	-8	hSpCas9	negative selection	1211095
68530303	68530326	17	-	26627737	RPE1	viability after 12 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	6.569344759849395	[2]	[128,20]	9	hSpCas9	negative selection	1211096
68515411	68515434	17	+	26627737	RPE1	viability after 15 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	-2.2658661370234014	[1093]	[72,55]	-8	hSpCas9	negative selection	1293406
68522843	68522866	17	-	26627737	RPE1	viability after 15 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	-1.3316625328123022	[2240]	[174,325]	-7	hSpCas9	negative selection	1293407
68522878	68522901	17	+	26627737	RPE1	viability after 15 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-1.006117334321517	[504]	[35,104]	-6	hSpCas9	negative selection	1293408
68528864	68528887	17	+	26627737	RPE1	viability after 15 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	-0.34317328733357944	[1087]	[235,248]	-2	hSpCas9	negative selection	1293409
68528917	68528940	17	-	26627737	RPE1	viability after 15 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	-3.195134439605766	[1277]	[40,37]	-9	hSpCas9	negative selection	1293410
68530303	68530326	17	-	26627737	RPE1	viability after 15 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	4.3801753590404715	[2]	[7,26]	9	hSpCas9	negative selection	1293411
68515411	68515434	17	+	26627737	RPE1	viability after 18 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	-2.1985885399736977	[1093]	[58,69]	-8	hSpCas9	negative selection	1375721
68522843	68522866	17	-	26627737	RPE1	viability after 18 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	-1.1438994831823166	[2240]	[176,376]	-6	hSpCas9	negative selection	1375722
68522878	68522901	17	+	26627737	RPE1	viability after 18 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-0.9541726145443106	[504]	[21,121]	-5	hSpCas9	negative selection	1375723
68528864	68528887	17	+	26627737	RPE1	viability after 18 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	-0.45272169292277403	[1087]	[200,228]	-3	hSpCas9	negative selection	1375724
68528917	68528940	17	-	26627737	RPE1	viability after 18 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	-3.0633087447655365	[1277]	[77,1]	-9	hSpCas9	negative selection	1375725
68530303	68530326	17	-	26627737	RPE1	viability after 18 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	4.779286356168383	[2]	[28,14]	9	hSpCas9	negative selection	1375726
68515411	68515434	17	+	26627737	HeLa	viability after 8 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	-0.059583749794797206	[370]	[205,174,98]	0	hSpCas9	negative selection	1458036
68522843	68522866	17	-	26627737	HeLa	viability after 8 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	0.5666747139583319	[793]	[774,467,360]	5	hSpCas9	negative selection	1458037
68522878	68522901	17	+	26627737	HeLa	viability after 8 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-1.1606034316694758	[856]	[260,164,99]	-8	hSpCas9	negative selection	1458038
68528864	68528887	17	+	26627737	HeLa	viability after 8 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	-0.26791999440109926	[588]	[209,215,211]	-3	hSpCas9	negative selection	1458039
68528917	68528940	17	-	26627737	HeLa	viability after 8 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	0.20209193135624454	[270]	[183,14,212]	2	hSpCas9	negative selection	1458040
68530303	68530326	17	-	26627737	HeLa	viability after 8 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	-0.1555860086351024	[409]	[232,139,125]	-1	hSpCas9	negative selection	1458041
68515411	68515434	17	+	26627737	HeLa	viability after 12 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	-0.902209749957798	[370]	[111,62,73]	-7	hSpCas9	negative selection	1540351
68522843	68522866	17	-	26627737	HeLa	viability after 12 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	0.2899921447923761	[793]	[347,372,483]	2	hSpCas9	negative selection	1540352
68522878	68522901	17	+	26627737	HeLa	viability after 12 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-0.03428780453454272	[856]	[328,487,204]	0	hSpCas9	negative selection	1540353
68528864	68528887	17	+	26627737	HeLa	viability after 12 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	0.16154221990766837	[588]	[202,250,362]	1	hSpCas9	negative selection	1540354
68528917	68528940	17	-	26627737	HeLa	viability after 12 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	0.2788147677204237	[270]	[172,132,102]	2	hSpCas9	negative selection	1540355
68530303	68530326	17	-	26627737	HeLa	viability after 12 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	-0.28460290872215116	[409]	[145,58,220]	-3	hSpCas9	negative selection	1540356
68515411	68515434	17	+	26627737	HeLa	viability after 15 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	-1.8988128476240922	[370]	[22,54,43]	-9	hSpCas9	negative selection	1622666
68522843	68522866	17	-	26627737	HeLa	viability after 15 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	-0.31868153559248125	[793]	[109,306,370]	-3	hSpCas9	negative selection	1622667
68522878	68522901	17	+	26627737	HeLa	viability after 15 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-0.30911707550054	[856]	[328,416,82]	-3	hSpCas9	negative selection	1622668
68528864	68528887	17	+	26627737	HeLa	viability after 15 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	-0.4469639339413808	[588]	[175,135,218]	-4	hSpCas9	negative selection	1622669
68528917	68528940	17	-	26627737	HeLa	viability after 15 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	-0.49406664047533344	[270]	[130,52,47]	-4	hSpCas9	negative selection	1622670
68530303	68530326	17	-	26627737	HeLa	viability after 15 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	0.2602471356753406	[409]	[293,146,153]	2	hSpCas9	negative selection	1622671
68515411	68515434	17	+	26627737	HeLa	viability after 18 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	-1.922172900738294	[370]	[16,41,43]	-9	hSpCas9	negative selection	1704981
68522843	68522866	17	-	26627737	HeLa	viability after 18 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	-0.3197393574136598	[793]	[71,255,370]	-3	hSpCas9	negative selection	1704982
68522878	68522901	17	+	26627737	HeLa	viability after 18 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-0.27059638965402466	[856]	[230,350,82]	-2	hSpCas9	negative selection	1704983
68528864	68528887	17	+	26627737	HeLa	viability after 18 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	-0.4664036831744101	[588]	[113,111,218]	-4	hSpCas9	negative selection	1704984
68528917	68528940	17	-	26627737	HeLa	viability after 18 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	-0.41489886221322003	[270]	[93,46,47]	-4	hSpCas9	negative selection	1704985
68530303	68530326	17	-	26627737	HeLa	viability after 18 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	0.27779903305778325	[409]	[200,122,153]	2	hSpCas9	negative selection	1704986
68515411	68515434	17	+	26627737	HCT116	viability after 6 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	-0.6878665835586298	[606]	[104,33]	-4	hSpCas9	negative selection	1787296
68522843	68522866	17	-	26627737	HCT116	viability after 6 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	0.49551119165232915	[947]	[358,127]	2	hSpCas9	negative selection	1787297
68522878	68522901	17	+	26627737	HCT116	viability after 6 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-0.8503786387026602	[1535]	[160,118]	-5	hSpCas9	negative selection	1787298
68528864	68528887	17	+	26627737	HCT116	viability after 6 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	1.5194443810751872	[605]	[120,356]	7	hSpCas9	negative selection	1787299
68528917	68528940	17	-	26627737	HCT116	viability after 6 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	-1.052638282379973	[676]	[69,40]	-6	hSpCas9	negative selection	1787300
68530303	68530326	17	-	26627737	HCT116	viability after 6 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	0.7941254387907715	[475]	[112,138]	4	hSpCas9	negative selection	1787301
68515411	68515434	17	+	26627737	HCT116	viability after 8 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	-1.2696044789451477	[216]	[67,21,58]	-9	hSpCas9	negative selection	1869611
68522843	68522866	17	-	26627737	HCT116	viability after 8 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	0.8350355257579661	[324]	[386,367,205]	7	hSpCas9	negative selection	1869612
68522878	68522901	17	+	26627737	HCT116	viability after 8 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-2.057685965312686	[603]	[51,79,106]	-9	hSpCas9	negative selection	1869613
68528864	68528887	17	+	26627737	HCT116	viability after 8 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	0.34111834019302056	[304]	[203,178,254]	3	hSpCas9	negative selection	1869614
68528917	68528940	17	-	26627737	HCT116	viability after 8 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	-0.40396613851377183	[370]	[98,165,196]	-5	hSpCas9	negative selection	1869615
68530303	68530326	17	-	26627737	HCT116	viability after 8 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	0.1010721966780459	[229]	[84,194,126]	1	hSpCas9	negative selection	1869616
68515411	68515434	17	+	26627737	HCT116	viability after 9 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	-0.965053759810007	[606]	[77,86]	-6	hSpCas9	negative selection	1951926
68522843	68522866	17	-	26627737	HCT116	viability after 9 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	0.7410062055607851	[947]	[264,547]	5	hSpCas9	negative selection	1951927
68522878	68522901	17	+	26627737	HCT116	viability after 9 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-2.55180415300413	[1535]	[141,12]	-9	hSpCas9	negative selection	1951928
68528864	68528887	17	+	26627737	HCT116	viability after 9 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	0.11732818235460482	[605]	[222,137]	0	hSpCas9	negative selection	1951929
68528917	68528940	17	-	26627737	HCT116	viability after 9 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	-0.8163247744189746	[676]	[186,35]	-5	hSpCas9	negative selection	1951930
68530303	68530326	17	-	26627737	HCT116	viability after 9 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	-0.995321614343962	[475]	[46,76]	-6	hSpCas9	negative selection	1951931
68515411	68515434	17	+	26627737	HCT116	viability after 12 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	-0.02342729716261721	[216]	[144,40,145]	0	hSpCas9	negative selection	2034241
68522843	68522866	17	-	26627737	HCT116	viability after 12 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	0.5883544796099132	[324]	[263,307,198]	5	hSpCas9	negative selection	2034242
68522878	68522901	17	+	26627737	HCT116	viability after 12 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-4.202019571292228	[603]	[11,8,30]	-9	hSpCas9	negative selection	2034243
68528864	68528887	17	+	26627737	HCT116	viability after 12 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	0.2365550708911955	[304]	[199,165,198]	2	hSpCas9	negative selection	2034244
68528917	68528940	17	-	26627737	HCT116	viability after 12 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	-0.4204182824506201	[370]	[82,163,195]	-4	hSpCas9	negative selection	2034245
68530303	68530326	17	-	26627737	HCT116	viability after 12 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	-0.5352244368654352	[229]	[104,69,72]	-5	hSpCas9	negative selection	2034246
68515411	68515434	17	+	26627737	HCT116	viability after 15 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	-0.1599087978501238	[216]	[186,59,96]	-2	hSpCas9	negative selection	2116556
68522843	68522866	17	-	26627737	HCT116	viability after 15 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	0.3099394442210457	[324]	[194,287,206]	3	hSpCas9	negative selection	2116557
68522878	68522901	17	+	26627737	HCT116	viability after 15 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-3.396560054392914	[603]	[6,0,86]	-9	hSpCas9	negative selection	2116558
68528864	68528887	17	+	26627737	HCT116	viability after 15 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	0.21194243310308783	[304]	[257,208,148]	2	hSpCas9	negative selection	2116559
68528917	68528940	17	-	26627737	HCT116	viability after 15 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	-0.4035855074771192	[370]	[152,148,179]	-4	hSpCas9	negative selection	2116560
68530303	68530326	17	-	26627737	HCT116	viability after 15 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	-0.7776748317671601	[229]	[184,41,17]	-7	hSpCas9	negative selection	2116561
68515411	68515434	17	+	26627737	HCT116	viability after 18 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	0.26139076688002555	[216]	[142,154,74]	2	hSpCas9	negative selection	2198871
68522843	68522866	17	-	26627737	HCT116	viability after 18 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	0.284203593674353	[324]	[251,174,145]	2	hSpCas9	negative selection	2198872
68522878	68522901	17	+	26627737	HCT116	viability after 18 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-2.336881116104018	[603]	[18,59,95]	-9	hSpCas9	negative selection	2198873
68528864	68528887	17	+	26627737	HCT116	viability after 18 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	-0.0333325375111482	[304]	[180,113,138]	0	hSpCas9	negative selection	2198874
68528917	68528940	17	-	26627737	HCT116	viability after 18 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	-0.8504281436225756	[370]	[75,69,156]	-7	hSpCas9	negative selection	2198875
68530303	68530326	17	-	26627737	HCT116	viability after 18 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	-0.6810579455287523	[229]	[147,28,31]	-6	hSpCas9	negative selection	2198876
68515388	68515411	17	+	24336569	HL60	viability	TCGCAGAGAACCATGGAGTCTGG	PRKAR1A	ENSG00000108946	-0.3120268925418881	[1150]	[1961]	-3	hSpCas9	negative selection	2286382
68515398	68515421	17	-	24336569	HL60	viability	GGCGGTACTGCCAGACTCCATGG	PRKAR1A	ENSG00000108946	-0.16585628791926876	[439]	[829]	-1	hSpCas9	negative selection	2286383
68515408	68515431	17	+	24336569	HL60	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	1.063914602504902	[381]	[1689]	7	hSpCas9	negative selection	2286384
68515416	68515439	17	-	24336569	HL60	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.22839116195789094	[575]	[1427]	2	hSpCas9	negative selection	2286385
68515422	68515445	17	-	24336569	HL60	viability	AAGGCTGCGTGCCTCCTCACTGG	PRKAR1A	ENSG00000108946	-0.2557622337642992	[412]	[731]	-2	hSpCas9	negative selection	2286386
68515441	68515464	17	-	24336569	HL60	viability	CGTAGAGCTCACATTCTCGAAGG	PRKAR1A	ENSG00000108946	0.11135881337423485	[506]	[1158]	1	hSpCas9	negative selection	2286387
68515465	68515488	17	-	24336569	HL60	viability	GCGCTTGAATGTTATGCTTCTGG	PRKAR1A	ENSG00000108946	0.48505184610686203	[996]	[2952]	4	hSpCas9	negative selection	2286388
68515526	68515549	17	-	24336569	HL60	viability	AGGAATGCCATGGGTCTCTCAGG	PRKAR1A	ENSG00000108946	0.4014637659212946	[453]	[1268]	3	hSpCas9	negative selection	2286389
68515531	68515554	17	+	24336569	HL60	viability	GAGACCCATGGCATTCCTCAGGG	PRKAR1A	ENSG00000108946	-3.3818590339666175	[132]	[26]	-9	hSpCas9	negative selection	2286390
68515536	68515559	17	-	24336569	HL60	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-1.6254699271271948	[763]	[523]	-8	hSpCas9	negative selection	2286391
68515388	68515411	17	+	24336569	KBM7	viability	TCGCAGAGAACCATGGAGTCTGG	PRKAR1A	ENSG00000108946	0.592123227484849	[671]	[2762]	5	hSpCas9	negative selection	2353559
68515398	68515421	17	-	24336569	KBM7	viability	GGCGGTACTGCCAGACTCCATGG	PRKAR1A	ENSG00000108946	-1.117363130335934	[485]	[610]	-7	hSpCas9	negative selection	2353560
68515408	68515431	17	+	24336569	KBM7	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	1.9854689673817714	[300]	[3250]	9	hSpCas9	negative selection	2353561
68515416	68515439	17	-	24336569	KBM7	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.23193853635226633	[373]	[1197]	2	hSpCas9	negative selection	2353562
68515422	68515445	17	-	24336569	KBM7	viability	AAGGCTGCGTGCCTCCTCACTGG	PRKAR1A	ENSG00000108946	-0.28377380148646836	[419]	[940]	-2	hSpCas9	negative selection	2353563
68515441	68515464	17	-	24336569	KBM7	viability	CGTAGAGCTCACATTCTCGAAGG	PRKAR1A	ENSG00000108946	0.486923630267496	[551]	[2109]	4	hSpCas9	negative selection	2353564
68515465	68515488	17	-	24336569	KBM7	viability	GCGCTTGAATGTTATGCTTCTGG	PRKAR1A	ENSG00000108946	0.5513914098713123	[700]	[2801]	5	hSpCas9	negative selection	2353565
68515526	68515549	17	-	24336569	KBM7	viability	AGGAATGCCATGGGTCTCTCAGG	PRKAR1A	ENSG00000108946	0.7036185968245244	[447]	[1989]	6	hSpCas9	negative selection	2353566
68515531	68515554	17	+	24336569	KBM7	viability	GAGACCCATGGCATTCCTCAGGG	PRKAR1A	ENSG00000108946	0.5056265919721761	[46]	[181]	4	hSpCas9	negative selection	2353567
68515536	68515559	17	-	24336569	KBM7	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-0.25574085968934873	[558]	[1276]	-2	hSpCas9	negative selection	2353568
68515131	68515154	17	+	25494202	A375	resistance to PLX-4720 (puromycin)	ATACTTCCTCCCAGGAGCTGAGG	PRKAR1A	ENSG00000108946	-1.351574590714112	[362,38]	[24,7]	-7	dCas9-VP64	positive selection	2418972
68515141	68515164	17	-	25494202	A375	resistance to PLX-4720 (puromycin)	GAGTCGATAACCTCAGCTCCTGG	PRKAR1A	ENSG00000108946	-1.0231505787966721	[108,118]	[13,9]	-6	dCas9-VP64	positive selection	2418973
68515173	68515196	17	-	25494202	A375	resistance to PLX-4720 (puromycin)	GTTCAGGATCTGTGCTCTGTAGG	PRKAR1A	ENSG00000108946	-0.24214456710840443	[21,107]	[15,6]	-1	dCas9-VP64	positive selection	2418974
68533936	68533959	17	-	25494202	A375	resistance to PLX-4720 (puromycin)	TTAGGAGTTCGAGACCAGCCTAG	PRKAR1A	ENSG00000108946	-0.8844378867613548	[237,84]	[20,15]	-5	dCas9-VP64	positive selection	2461506
68512193	68512216	17	+	25494202	A375	resistance to PLX-4720 (puromycin)	CTGCGGAAAGGAGAAGTGGCGGG	PRKAR1A	ENSG00000108946	2.679704580814825	[18,13]	[14,32]	8	dCas9-VP64	positive selection	2478217
68512219	68512242	17	+	25494202	A375	resistance to PLX-4720 (puromycin)	GAGGAAACTGCTGTGGATAAGGG	PRKAR1A	ENSG00000108946	2.450610250070548	[139,23]	[183,2]	7	dCas9-VP64	positive selection	2478218
68512278	68512301	17	-	25494202	A375	resistance to PLX-4720 (puromycin)	TTGGAAGGACCCTCACTCTGCGG	PRKAR1A	ENSG00000108946	0.7286354022749186	[21,70]	[10,22]	3	dCas9-VP64	positive selection	2478219
68515131	68515154	17	+	25494202	A375	resistance to PLX-4720 (zeocin)	ATACTTCCTCCCAGGAGCTGAGG	PRKAR1A	ENSG00000108946	0.6477162351992192	[75,55]	[39,26]	5	dCas9-VP64	positive selection	2514227
68515141	68515164	17	-	25494202	A375	resistance to PLX-4720 (zeocin)	GAGTCGATAACCTCAGCTCCTGG	PRKAR1A	ENSG00000108946	0.5885972838245834	[126,142]	[55,75]	4	dCas9-VP64	positive selection	2514228
68515173	68515196	17	-	25494202	A375	resistance to PLX-4720 (zeocin)	GTTCAGGATCTGTGCTCTGTAGG	PRKAR1A	ENSG00000108946	0.09703612084703858	[82,145]	[16,60]	0	dCas9-VP64	positive selection	2514229
68533936	68533959	17	-	25494202	A375	resistance to PLX-4720 (zeocin)	TTAGGAGTTCGAGACCAGCCTAG	PRKAR1A	ENSG00000108946	2.6650986342381273	[238,153]	[58,738]	9	dCas9-VP64	positive selection	2556761
68512193	68512216	17	+	25494202	A375	resistance to PLX-4720 (zeocin)	CTGCGGAAAGGAGAAGTGGCGGG	PRKAR1A	ENSG00000108946	0.49416944848292005	[73,56]	[28,29]	4	dCas9-VP64	positive selection	2573472
68512219	68512242	17	+	25494202	A375	resistance to PLX-4720 (zeocin)	GAGGAAACTGCTGTGGATAAGGG	PRKAR1A	ENSG00000108946	0.5742820450143454	[104,67]	[64,20]	4	dCas9-VP64	positive selection	2573473
68512278	68512301	17	-	25494202	A375	resistance to PLX-4720 (zeocin)	TTGGAAGGACCCTCACTCTGCGG	PRKAR1A	ENSG00000108946	-0.6449367806766826	[125,154]	[32,24]	-6	dCas9-VP64	positive selection	2573474
68515388	68515411	17	+	27260157	DLD1	viability	TCGCAGAGAACCATGGAGTCTGG	PRKAR1A	ENSG00000108946	0.0748493379871014	[]	[]	3	hSpCas9	negative selection	2574538
68522790	68522813	17	+	27260157	DLD1	viability	CAGGCACTCGTACAGACTCAAGG	PRKAR1A	ENSG00000108946	-1.26844081069832	[]	[]	-7	hSpCas9	negative selection	2576750
68522838	68522861	17	-	27260157	DLD1	viability	CCTACCTTTAACCACTGGGTTGG	PRKAR1A	ENSG00000108946	-0.156889920179043	[]	[]	-1	hSpCas9	negative selection	2577957
68515531	68515554	17	+	27260157	DLD1	viability	GAGACCCATGGCATTCCTCAGGG	PRKAR1A	ENSG00000108946	-0.517593439544883	[]	[]	-4	hSpCas9	negative selection	2578038
68527838	68527861	17	+	27260157	DLD1	viability	AGGGAAGCACACTGAGAAAGCGG	PRKAR1A	ENSG00000108946	-0.198956565896041	[]	[]	-1	hSpCas9	negative selection	2578253
68515408	68515431	17	+	27260157	DLD1	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.714911213093277	[]	[]	-5	hSpCas9	negative selection	2579471
68525766	68525789	17	+	27260157	DLD1	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	-0.303758195542037	[]	[]	-2	hSpCas9	negative selection	2579738
68515536	68515559	17	-	27260157	DLD1	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	0.485580519012151	[]	[]	8	hSpCas9	negative selection	2582837
68522866	68522889	17	+	27260157	DLD1	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	-1.13968207025091	[]	[]	-7	hSpCas9	negative selection	2584153
68515530	68515553	17	+	27260157	DLD1	viability	AGAGACCCATGGCATTCCTCAGG	PRKAR1A	ENSG00000108946	-0.277285150140334	[]	[]	-2	hSpCas9	negative selection	2586066
68515465	68515488	17	-	27260157	DLD1	viability	GCGCTTGAATGTTATGCTTCTGG	PRKAR1A	ENSG00000108946	-0.162404287416332	[]	[]	-1	hSpCas9	negative selection	2587338
68522878	68522901	17	+	27260157	DLD1	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-1.19375633047458	[]	[]	-7	hSpCas9	negative selection	2604126
68522849	68522872	17	+	27260157	DLD1	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-0.999205886481243	[]	[]	-7	hSpCas9	negative selection	2607550
68515441	68515464	17	-	27260157	DLD1	viability	CGTAGAGCTCACATTCTCGAAGG	PRKAR1A	ENSG00000108946	0.675030850020952	[]	[]	8	hSpCas9	negative selection	2611649
68524045	68524068	17	-	27260157	DLD1	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.589730798337322	[]	[]	8	hSpCas9	negative selection	2621864
68515398	68515421	17	-	27260157	DLD1	viability	GGCGGTACTGCCAGACTCCATGG	PRKAR1A	ENSG00000108946	-0.113670057721529	[]	[]	-1	hSpCas9	negative selection	2643260
68515422	68515445	17	-	27260157	DLD1	viability	AAGGCTGCGTGCCTCCTCACTGG	PRKAR1A	ENSG00000108946	-1.54129364966772	[]	[]	-8	hSpCas9	negative selection	2646673
68527851	68527874	17	+	27260157	DLD1	viability	GAGAAAGCGGAAGATGTATGAGG	PRKAR1A	ENSG00000108946	1.10416944756103	[]	[]	9	hSpCas9	negative selection	2647849
68515526	68515549	17	-	27260157	DLD1	viability	AGGAATGCCATGGGTCTCTCAGG	PRKAR1A	ENSG00000108946	-0.384645297321366	[]	[]	-3	hSpCas9	negative selection	2648002
68515416	68515439	17	-	27260157	DLD1	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.871486166455042	[]	[]	-6	hSpCas9	negative selection	2648586
68515388	68515411	17	+	27260157	HT1080	viability	TCGCAGAGAACCATGGAGTCTGG	PRKAR1A	ENSG00000108946	0.257594807919268	[]	[]	2	hSpCas9	negative selection	2650668
68522790	68522813	17	+	27260157	HT1080	viability	CAGGCACTCGTACAGACTCAAGG	PRKAR1A	ENSG00000108946	-0.328107707124718	[]	[]	-7	hSpCas9	negative selection	2652880
68522838	68522861	17	-	27260157	HT1080	viability	CCTACCTTTAACCACTGGGTTGG	PRKAR1A	ENSG00000108946	-0.389859351098078	[]	[]	-7	hSpCas9	negative selection	2654087
68515531	68515554	17	+	27260157	HT1080	viability	GAGACCCATGGCATTCCTCAGGG	PRKAR1A	ENSG00000108946	-0.341362348521208	[]	[]	-7	hSpCas9	negative selection	2654168
68527838	68527861	17	+	27260157	HT1080	viability	AGGGAAGCACACTGAGAAAGCGG	PRKAR1A	ENSG00000108946	0.176854930232554	[]	[]	1	hSpCas9	negative selection	2654383
68515408	68515431	17	+	27260157	HT1080	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.55847506492799	[]	[]	-7	hSpCas9	negative selection	2655601
68525766	68525789	17	+	27260157	HT1080	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	-0.158370049174168	[]	[]	0	hSpCas9	negative selection	2655868
68515536	68515559	17	-	27260157	HT1080	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-0.00249805190842875	[]	[]	0	hSpCas9	negative selection	2658967
68522866	68522889	17	+	27260157	HT1080	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	-0.522826524905099	[]	[]	-7	hSpCas9	negative selection	2660283
68515530	68515553	17	+	27260157	HT1080	viability	AGAGACCCATGGCATTCCTCAGG	PRKAR1A	ENSG00000108946	-0.593666595333764	[]	[]	-7	hSpCas9	negative selection	2662196
68515465	68515488	17	-	27260157	HT1080	viability	GCGCTTGAATGTTATGCTTCTGG	PRKAR1A	ENSG00000108946	-0.419859849591847	[]	[]	-7	hSpCas9	negative selection	2663468
68522878	68522901	17	+	27260157	HT1080	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-0.145848722652104	[]	[]	0	hSpCas9	negative selection	2680256
68522849	68522872	17	+	27260157	HT1080	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-1.05130933402339	[]	[]	-8	hSpCas9	negative selection	2683680
68515441	68515464	17	-	27260157	HT1080	viability	CGTAGAGCTCACATTCTCGAAGG	PRKAR1A	ENSG00000108946	-0.589014762559199	[]	[]	-7	hSpCas9	negative selection	2687779
68524045	68524068	17	-	27260157	HT1080	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	-0.0670867549657407	[]	[]	0	hSpCas9	negative selection	2697994
68515398	68515421	17	-	27260157	HT1080	viability	GGCGGTACTGCCAGACTCCATGG	PRKAR1A	ENSG00000108946	0.0597374615886414	[]	[]	0	hSpCas9	negative selection	2719390
68515422	68515445	17	-	27260157	HT1080	viability	AAGGCTGCGTGCCTCCTCACTGG	PRKAR1A	ENSG00000108946	-0.570183699432997	[]	[]	-7	hSpCas9	negative selection	2722803
68527851	68527874	17	+	27260157	HT1080	viability	GAGAAAGCGGAAGATGTATGAGG	PRKAR1A	ENSG00000108946	0.0869225819279382	[]	[]	1	hSpCas9	negative selection	2723979
68515526	68515549	17	-	27260157	HT1080	viability	AGGAATGCCATGGGTCTCTCAGG	PRKAR1A	ENSG00000108946	-0.445695110736912	[]	[]	-7	hSpCas9	negative selection	2724132
68515416	68515439	17	-	27260157	HT1080	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	1.34950215998675	[]	[]	9	hSpCas9	negative selection	2724716
68515388	68515411	17	+	27260157	MKN45	viability	TCGCAGAGAACCATGGAGTCTGG	PRKAR1A	ENSG00000108946	0.58073041093184	[]	[]	7	hSpCas9	negative selection	2726798
68522790	68522813	17	+	27260157	MKN45	viability	CAGGCACTCGTACAGACTCAAGG	PRKAR1A	ENSG00000108946	-0.423038658654184	[]	[]	-6	hSpCas9	negative selection	2729010
68522838	68522861	17	-	27260157	MKN45	viability	CCTACCTTTAACCACTGGGTTGG	PRKAR1A	ENSG00000108946	0.105733628452286	[]	[]	0	hSpCas9	negative selection	2730217
68515531	68515554	17	+	27260157	MKN45	viability	GAGACCCATGGCATTCCTCAGGG	PRKAR1A	ENSG00000108946	0.213604198947543	[]	[]	5	hSpCas9	negative selection	2730298
68527838	68527861	17	+	27260157	MKN45	viability	AGGGAAGCACACTGAGAAAGCGG	PRKAR1A	ENSG00000108946	0.689523578211694	[]	[]	7	hSpCas9	negative selection	2730513
68515408	68515431	17	+	27260157	MKN45	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.784348961907033	[]	[]	-7	hSpCas9	negative selection	2731731
68525766	68525789	17	+	27260157	MKN45	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	-1.1195532234544	[]	[]	-8	hSpCas9	negative selection	2731998
68515536	68515559	17	-	27260157	MKN45	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	0.218067306906147	[]	[]	5	hSpCas9	negative selection	2735097
68522866	68522889	17	+	27260157	MKN45	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	-0.722537215115279	[]	[]	-7	hSpCas9	negative selection	2736413
68515530	68515553	17	+	27260157	MKN45	viability	AGAGACCCATGGCATTCCTCAGG	PRKAR1A	ENSG00000108946	0.0546927178463073	[]	[]	0	hSpCas9	negative selection	2738326
68515465	68515488	17	-	27260157	MKN45	viability	GCGCTTGAATGTTATGCTTCTGG	PRKAR1A	ENSG00000108946	-0.937266426214814	[]	[]	-7	hSpCas9	negative selection	2739598
68522878	68522901	17	+	27260157	MKN45	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-0.0295949448339639	[]	[]	0	hSpCas9	negative selection	2756386
68522849	68522872	17	+	27260157	MKN45	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-0.399269761540648	[]	[]	-1	hSpCas9	negative selection	2759810
68515441	68515464	17	-	27260157	MKN45	viability	CGTAGAGCTCACATTCTCGAAGG	PRKAR1A	ENSG00000108946	-0.852608112438985	[]	[]	-7	hSpCas9	negative selection	2763909
68524045	68524068	17	-	27260157	MKN45	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	1.04780784255482	[]	[]	8	hSpCas9	negative selection	2774124
68515398	68515421	17	-	27260157	MKN45	viability	GGCGGTACTGCCAGACTCCATGG	PRKAR1A	ENSG00000108946	0.140881003008866	[]	[]	5	hSpCas9	negative selection	2795520
68515422	68515445	17	-	27260157	MKN45	viability	AAGGCTGCGTGCCTCCTCACTGG	PRKAR1A	ENSG00000108946	-0.396388209804166	[]	[]	-1	hSpCas9	negative selection	2798933
68527851	68527874	17	+	27260157	MKN45	viability	GAGAAAGCGGAAGATGTATGAGG	PRKAR1A	ENSG00000108946	0.383418363637202	[]	[]	6	hSpCas9	negative selection	2800109
68515526	68515549	17	-	27260157	MKN45	viability	AGGAATGCCATGGGTCTCTCAGG	PRKAR1A	ENSG00000108946	-0.345600951540378	[]	[]	-1	hSpCas9	negative selection	2800262
68515416	68515439	17	-	27260157	MKN45	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.82068399342403	[]	[]	8	hSpCas9	negative selection	2800846
68515388	68515411	17	+	27260157	RKO	viability	TCGCAGAGAACCATGGAGTCTGG	PRKAR1A	ENSG00000108946	0.248640157840382	[]	[]	1	hSpCas9	negative selection	2802928
68522790	68522813	17	+	27260157	RKO	viability	CAGGCACTCGTACAGACTCAAGG	PRKAR1A	ENSG00000108946	-0.504416409296581	[]	[]	-6	hSpCas9	negative selection	2805140
68522838	68522861	17	-	27260157	RKO	viability	CCTACCTTTAACCACTGGGTTGG	PRKAR1A	ENSG00000108946	0.0107285993348758	[]	[]	0	hSpCas9	negative selection	2806347
68515531	68515554	17	+	27260157	RKO	viability	GAGACCCATGGCATTCCTCAGGG	PRKAR1A	ENSG00000108946	1.08319480802802	[]	[]	9	hSpCas9	negative selection	2806428
68527838	68527861	17	+	27260157	RKO	viability	AGGGAAGCACACTGAGAAAGCGG	PRKAR1A	ENSG00000108946	0.0366105279373624	[]	[]	0	hSpCas9	negative selection	2806643
68515408	68515431	17	+	27260157	RKO	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.612913268212172	[]	[]	-7	hSpCas9	negative selection	2807861
68525766	68525789	17	+	27260157	RKO	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	0.289939960757189	[]	[]	1	hSpCas9	negative selection	2808128
68515536	68515559	17	-	27260157	RKO	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-0.715858418776791	[]	[]	-7	hSpCas9	negative selection	2811227
68522866	68522889	17	+	27260157	RKO	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	0.255293799663169	[]	[]	1	hSpCas9	negative selection	2812543
68515530	68515553	17	+	27260157	RKO	viability	AGAGACCCATGGCATTCCTCAGG	PRKAR1A	ENSG00000108946	0.257005848497234	[]	[]	1	hSpCas9	negative selection	2814456
68515465	68515488	17	-	27260157	RKO	viability	GCGCTTGAATGTTATGCTTCTGG	PRKAR1A	ENSG00000108946	-0.966445103847768	[]	[]	-8	hSpCas9	negative selection	2815728
68522878	68522901	17	+	27260157	RKO	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-0.0084742956837566	[]	[]	0	hSpCas9	negative selection	2832516
68522849	68522872	17	+	27260157	RKO	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-0.300483090976358	[]	[]	-6	hSpCas9	negative selection	2835940
68515441	68515464	17	-	27260157	RKO	viability	CGTAGAGCTCACATTCTCGAAGG	PRKAR1A	ENSG00000108946	-0.304611076524947	[]	[]	-6	hSpCas9	negative selection	2840039
68524045	68524068	17	-	27260157	RKO	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.665655874004083	[]	[]	3	hSpCas9	negative selection	2850254
68515398	68515421	17	-	27260157	RKO	viability	GGCGGTACTGCCAGACTCCATGG	PRKAR1A	ENSG00000108946	0.026291776664041	[]	[]	0	hSpCas9	negative selection	2871650
68515422	68515445	17	-	27260157	RKO	viability	AAGGCTGCGTGCCTCCTCACTGG	PRKAR1A	ENSG00000108946	0.471998465668452	[]	[]	2	hSpCas9	negative selection	2875063
68527851	68527874	17	+	27260157	RKO	viability	GAGAAAGCGGAAGATGTATGAGG	PRKAR1A	ENSG00000108946	0.641964605669172	[]	[]	3	hSpCas9	negative selection	2876239
68515526	68515549	17	-	27260157	RKO	viability	AGGAATGCCATGGGTCTCTCAGG	PRKAR1A	ENSG00000108946	0.0512161432463085	[]	[]	0	hSpCas9	negative selection	2876392
68515416	68515439	17	-	27260157	RKO	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-1.35961497827353	[]	[]	-8	hSpCas9	negative selection	2876976
68515388	68515411	17	+	27260157	SF268	viability	TCGCAGAGAACCATGGAGTCTGG	PRKAR1A	ENSG00000108946	0.180087014902234	[]	[]	0	hSpCas9	negative selection	2879058
68522790	68522813	17	+	27260157	SF268	viability	CAGGCACTCGTACAGACTCAAGG	PRKAR1A	ENSG00000108946	-1.77825742886847	[]	[]	-8	hSpCas9	negative selection	2881270
68522838	68522861	17	-	27260157	SF268	viability	CCTACCTTTAACCACTGGGTTGG	PRKAR1A	ENSG00000108946	-0.897877398845696	[]	[]	-6	hSpCas9	negative selection	2882477
68515531	68515554	17	+	27260157	SF268	viability	GAGACCCATGGCATTCCTCAGGG	PRKAR1A	ENSG00000108946	-1.3972047422909	[]	[]	-8	hSpCas9	negative selection	2882558
68527838	68527861	17	+	27260157	SF268	viability	AGGGAAGCACACTGAGAAAGCGG	PRKAR1A	ENSG00000108946	-1.8186402442177	[]	[]	-8	hSpCas9	negative selection	2882773
68515408	68515431	17	+	27260157	SF268	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-1.35220996181424	[]	[]	-7	hSpCas9	negative selection	2883991
68525766	68525789	17	+	27260157	SF268	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	-0.545781138113628	[]	[]	-4	hSpCas9	negative selection	2884258
68515536	68515559	17	-	27260157	SF268	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-1.37822165412893	[]	[]	-7	hSpCas9	negative selection	2887357
68522866	68522889	17	+	27260157	SF268	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	-1.7193191059862	[]	[]	-8	hSpCas9	negative selection	2888673
68515530	68515553	17	+	27260157	SF268	viability	AGAGACCCATGGCATTCCTCAGG	PRKAR1A	ENSG00000108946	-1.164504015821	[]	[]	-7	hSpCas9	negative selection	2890586
68515465	68515488	17	-	27260157	SF268	viability	GCGCTTGAATGTTATGCTTCTGG	PRKAR1A	ENSG00000108946	-0.216467373947457	[]	[]	-2	hSpCas9	negative selection	2891858
68522878	68522901	17	+	27260157	SF268	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-1.57320798457103	[]	[]	-8	hSpCas9	negative selection	2908646
68522849	68522872	17	+	27260157	SF268	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-1.3942580713656	[]	[]	-8	hSpCas9	negative selection	2912070
68515441	68515464	17	-	27260157	SF268	viability	CGTAGAGCTCACATTCTCGAAGG	PRKAR1A	ENSG00000108946	0.166044248106868	[]	[]	0	hSpCas9	negative selection	2916169
68524045	68524068	17	-	27260157	SF268	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	-0.169427095142138	[]	[]	-1	hSpCas9	negative selection	2926384
68515398	68515421	17	-	27260157	SF268	viability	GGCGGTACTGCCAGACTCCATGG	PRKAR1A	ENSG00000108946	-0.877113307092148	[]	[]	-6	hSpCas9	negative selection	2947780
68515422	68515445	17	-	27260157	SF268	viability	AAGGCTGCGTGCCTCCTCACTGG	PRKAR1A	ENSG00000108946	-0.987417614307818	[]	[]	-7	hSpCas9	negative selection	2951193
68527851	68527874	17	+	27260157	SF268	viability	GAGAAAGCGGAAGATGTATGAGG	PRKAR1A	ENSG00000108946	-1.43865157411075	[]	[]	-8	hSpCas9	negative selection	2952369
68515526	68515549	17	-	27260157	SF268	viability	AGGAATGCCATGGGTCTCTCAGG	PRKAR1A	ENSG00000108946	-0.98036872316927	[]	[]	-7	hSpCas9	negative selection	2952522
68515416	68515439	17	-	27260157	SF268	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.155230827188762	[]	[]	-1	hSpCas9	negative selection	2953106
68515416	68515439	17	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.26267979967834076	[4,4]	[4,4]	5	hSpCas9	positive selection	3013641
68524057	68524080	17	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	-0.10910101810911005	[4,4]	[4,2]	-1	hSpCas9	positive selection	3013642
68515536	68515559	17	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-0.6425155821711255	[3,3]	[2,0]	-7	hSpCas9	positive selection	3013643
68522876	68522899	17	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TATCAGCGCTGAGGTCTACACGG	PRKAR1A	ENSG00000108946	-0.008121809992719525	[3,3]	[4,2]	0	hSpCas9	positive selection	3013644
68515416	68515439	17	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.2369575560207812	[4,4]	[3,3]	4	hSpCas9	positive selection	3081499
68524057	68524080	17	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	-0.09823543704385665	[4,4]	[4,1]	-1	hSpCas9	positive selection	3081500
68515536	68515559	17	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-0.16208341529959883	[3,3]	[2,1]	-2	hSpCas9	positive selection	3081501
68522876	68522899	17	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TATCAGCGCTGAGGTCTACACGG	PRKAR1A	ENSG00000108946	0.02014234445180904	[3,3]	[2,2]	0	hSpCas9	positive selection	3081502
68522794	68522817		+	24336571	A375	resistance to PLX after 7 days	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	0.10808065809563838	[5,8]	[8,7]	3	hSpCas9	positive selection	3137765
68515465	68515488		-	24336571	A375	resistance to PLX after 7 days	GCGCTTGAATGTTATGCTTCTGG	PRKAR1A	ENSG00000108946	-0.061179383973477094	[10,16]	[12,13]	-2	hSpCas9	positive selection	3137766
68515416	68515439		-	24336571	A375	resistance to PLX after 7 days	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.13184731945643485	[9,9]	[8,7]	-4	hSpCas9	positive selection	3137767
68522905	68522928		+	24336571	A375	resistance to PLX after 7 days	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.23404060006722122	[10,12]	[13,14]	7	hSpCas9	positive selection	3137768
68522794	68522817		+	24336571	A375	resistance to PLX after 14 days	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	2.1390133814679393	[4,6]	[10,14]	9	hSpCas9	positive selection	3195558
68515465	68515488		-	24336571	A375	resistance to PLX after 14 days	GCGCTTGAATGTTATGCTTCTGG	PRKAR1A	ENSG00000108946	-0.3227514726174719	[15,14]	[5,4]	-4	hSpCas9	positive selection	3195559
68515416	68515439		-	24336571	A375	resistance to PLX after 14 days	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-1.193462659915062	[16,8]	[2,1]	-9	hSpCas9	positive selection	3195560
68522905	68522928		+	24336571	A375	resistance to PLX after 14 days	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.4686372884498493	[15,13]	[8,9]	4	hSpCas9	positive selection	3195561
68522794	68522817		+	24336571	A375	viability after 7 days	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	0.2284428281962837	[6]	[5,8]	3	hSpCas9	negative selection	3253351
68515465	68515488		-	24336571	A375	viability after 7 days	GCGCTTGAATGTTATGCTTCTGG	PRKAR1A	ENSG00000108946	-0.021181678883810312	[14]	[10,16]	0	hSpCas9	negative selection	3253352
68515416	68515439		-	24336571	A375	viability after 7 days	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.23657899479101147	[8]	[9,9]	3	hSpCas9	negative selection	3253353
68522905	68522928		+	24336571	A375	viability after 7 days	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.09796167762021031	[11]	[10,12]	1	hSpCas9	negative selection	3253354
68522794	68522817		+	24336571	A375	viability after 14 days	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.09256011887376481	[6]	[4,6]	-1	hSpCas9	negative selection	3311144
68515465	68515488		-	24336571	A375	viability after 14 days	GCGCTTGAATGTTATGCTTCTGG	PRKAR1A	ENSG00000108946	0.09384704829964768	[14]	[15,14]	1	hSpCas9	negative selection	3311145
68515416	68515439		-	24336571	A375	viability after 14 days	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.5966437979694847	[8]	[16,8]	7	hSpCas9	negative selection	3311146
68522905	68522928		+	24336571	A375	viability after 14 days	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.4077502337965824	[11]	[15,13]	5	hSpCas9	negative selection	3311147
68524045	68524068	17	-	27383988	293T	resistance to West Nile virus (flavivirus)	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	-1.086969696469982	[324,324]	[0,0]	-7	hSpCas9	positive selection	3387467
68515416	68515439	17	-	27383988	293T	resistance to West Nile virus (flavivirus)	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.35000410230377543	[194,194]	[0,0]	-2	hSpCas9	positive selection	3387468
68524056	68524079	17	+	27383988	293T	resistance to West Nile virus (flavivirus)	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	-1.9100919343859024	[574,574]	[0,0]	-9	hSpCas9	positive selection	3387469
68515416	68515439	17	-	26780180	HT29	viability (Avana library 4 designs)	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.189158223043811	[]	[]	0	hSpCas9	negative selection	3451828
68524056	68524079	17	+	26780180	HT29	viability (Avana library 4 designs)	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.258680019376942	[]	[]	0	hSpCas9	negative selection	3451829
68515536	68515559	17	-	26780180	HT29	viability (Avana library 4 designs)	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	0.310592552725215	[]	[]	1	hSpCas9	negative selection	3451830
68522875	68522898	17	+	26780180	HT29	viability (Avana library 4 designs)	TATCAGCGCTGAGGTCTACACGG	PRKAR1A	ENSG00000108946	0.222204876802557	[]	[]	0	hSpCas9	negative selection	3451831
68515416	68515439	17	-	26780180	A375	viability (Avana lentiCRISPRv2)	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	5.49523455994705	[]	[]	8	hSpCas9	negative selection	3547910
68515536	68515559	17	-	26780180	A375	viability (Avana lentiCRISPRv2)	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	0.594369361854102	[]	[]	0	hSpCas9	negative selection	3547911
68524056	68524079	17	+	26780180	A375	viability (Avana lentiCRISPRv2)	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	3.75228683813339	[]	[]	6	hSpCas9	negative selection	3547912
68522875	68522898	17	+	26780180	A375	viability (Avana lentiCRISPRv2)	TATCAGCGCTGAGGTCTACACGG	PRKAR1A	ENSG00000108946	0.99896753531485	[]	[]	1	hSpCas9	negative selection	3547913
68515441	68515464	17	-	26780180	A375	viability (Avana lentiCRISPRv2)	CGTAGAGCTCACATTCTCGAAGG	PRKAR1A	ENSG00000108946	-2.99792861080228	[]	[]	-4	hSpCas9	negative selection	3547914
68515531	68515554	17	+	26780180	A375	viability (Avana lentiCRISPRv2)	GAGACCCATGGCATTCCTCAGGG	PRKAR1A	ENSG00000108946	1.97023146878433	[]	[]	3	hSpCas9	negative selection	3547915
68515416	68515439	17	-	26780180	A375	viability (Avana lentiGuide)	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	4.30649814859509	[]	[]	4	hSpCas9	negative selection	3656569
68515536	68515559	17	-	26780180	A375	viability (Avana lentiGuide)	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-0.547094889055366	[]	[]	-1	hSpCas9	negative selection	3656570
68524056	68524079	17	+	26780180	A375	viability (Avana lentiGuide)	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	-1.80419691828151	[]	[]	-3	hSpCas9	negative selection	3656571
68522875	68522898	17	+	26780180	A375	viability (Avana lentiGuide)	TATCAGCGCTGAGGTCTACACGG	PRKAR1A	ENSG00000108946	5.400454335569	[]	[]	5	hSpCas9	negative selection	3656572
68515441	68515464	17	-	26780180	A375	viability (Avana lentiGuide)	CGTAGAGCTCACATTCTCGAAGG	PRKAR1A	ENSG00000108946	0.763914591196756	[]	[]	0	hSpCas9	negative selection	3656573
68515531	68515554	17	+	26780180	A375	viability (Avana lentiGuide)	GAGACCCATGGCATTCCTCAGGG	PRKAR1A	ENSG00000108946	7.4193373695646	[]	[]	6	hSpCas9	negative selection	3656574
68515416	68515439	17	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.15539771161360114	[5]	[5,5]	4	hSpCas9	positive selection	3765176
68515536	68515559	17	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-0.012327329283426294	[5]	[5,4]	0	hSpCas9	positive selection	3765177
68524056	68524079	17	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.35611719117909874	[5]	[7,6]	9	hSpCas9	positive selection	3765178
68522875	68522898	17	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TATCAGCGCTGAGGTCTACACGG	PRKAR1A	ENSG00000108946	0.29844732299105675	[5]	[6,5]	8	hSpCas9	positive selection	3765179
68515441	68515464	17	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CGTAGAGCTCACATTCTCGAAGG	PRKAR1A	ENSG00000108946	-0.34640419860587957	[4]	[3,3]	-5	hSpCas9	positive selection	3765180
68515531	68515554	17	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GAGACCCATGGCATTCCTCAGGG	PRKAR1A	ENSG00000108946	0.17885163692503478	[5]	[6,6]	5	hSpCas9	positive selection	3765181
68515416	68515439	17	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.08690961182837378	[6]	[5,5]	2	hSpCas9	positive selection	3873783
68515536	68515559	17	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-0.3795255596231149	[5]	[4,1]	-5	hSpCas9	positive selection	3873784
68524056	68524079	17	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	-0.21938479661065086	[6]	[2,5]	-3	hSpCas9	positive selection	3873785
68522875	68522898	17	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TATCAGCGCTGAGGTCTACACGG	PRKAR1A	ENSG00000108946	0.2533469718111403	[5]	[5,5]	6	hSpCas9	positive selection	3873786
68515441	68515464	17	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CGTAGAGCTCACATTCTCGAAGG	PRKAR1A	ENSG00000108946	0.1115556924361451	[5]	[5,4]	2	hSpCas9	positive selection	3873787
68515531	68515554	17	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GAGACCCATGGCATTCCTCAGGG	PRKAR1A	ENSG00000108946	-0.06324455902039561	[6]	[5,4]	-1	hSpCas9	positive selection	3873788
68524045	68524068	17	-	26780180	A375	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.443980893431388	[]	[]	1	hSpCas9	negative selection	3984237
68522794	68522817	17	+	26780180	A375	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	0.881238269563658	[]	[]	3	hSpCas9	negative selection	3984238
68515416	68515439	17	-	26780180	A375	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.84898521389659	[]	[]	3	hSpCas9	negative selection	3984239
68524056	68524079	17	+	26780180	A375	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.188768510873661	[]	[]	0	hSpCas9	negative selection	3984240
68522905	68522928	17	+	26780180	A375	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.446747952130749	[]	[]	1	hSpCas9	negative selection	3984241
68515408	68515431	17	+	26780180	A375	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	1.08539529062224	[]	[]	5	hSpCas9	negative selection	3984242
68524045	68524068	17	-	26780180	HT29	viability (GeCKOv2 library)	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.785889884419998	[]	[]	3	hSpCas9	negative selection	4092203
68522794	68522817	17	+	26780180	HT29	viability (GeCKOv2 library)	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	1.09258477757875	[]	[]	5	hSpCas9	negative selection	4092204
68515416	68515439	17	-	26780180	HT29	viability (GeCKOv2 library)	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	1.20436552007948	[]	[]	6	hSpCas9	negative selection	4092205
68524056	68524079	17	+	26780180	HT29	viability (GeCKOv2 library)	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.050534332529158	[]	[]	0	hSpCas9	negative selection	4092206
68522905	68522928	17	+	26780180	HT29	viability (GeCKOv2 library)	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.799019279978199	[]	[]	3	hSpCas9	negative selection	4092207
68515408	68515431	17	+	26780180	HT29	viability (GeCKOv2 library)	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	0.635266721170785	[]	[]	2	hSpCas9	negative selection	4092208
68522794	68522817	17	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	0.6421780702894753	[2]	[2,3]	9	hSpCas9	positive selection	4162920
68515465	68515488	17	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GCGCTTGAATGTTATGCTTCTGG	PRKAR1A	ENSG00000108946	0.08182173645275323	[3]	[2,2]	2	hSpCas9	positive selection	4162921
68515416	68515439	17	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.2461304011465364	[2]	[1,0]	-5	hSpCas9	positive selection	4162922
68522905	68522928	17	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.32668699342995056	[3]	[3,3]	7	hSpCas9	positive selection	4162923
68522794	68522817	17	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.1697391447379044	[2]	[0,0,0,0]	-2	hSpCas9	positive selection	4226942
68515465	68515488	17	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GCGCTTGAATGTTATGCTTCTGG	PRKAR1A	ENSG00000108946	0.12338498642132811	[1]	[0,2,0,0]	1	hSpCas9	positive selection	4226943
68515416	68515439	17	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.32339002817494317	[2]	[0,2,0,0]	-5	hSpCas9	positive selection	4226944
68522905	68522928	17	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.6056165882905532	[2]	[1,3,3,0]	4	hSpCas9	positive selection	4226945
68515408	68515431	17	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.04903838822136703	[3]	[3,1]	-1	hSpCas9	positive selection	4292156
68522794	68522817	17	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	0.21476237922669905	[1]	[1,0]	4	hSpCas9	positive selection	4292157
68522905	68522928	17	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.942321664773275	[1]	[1,2]	9	hSpCas9	positive selection	4292158
68524045	68524068	17	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	-0.043209137278626186	[3]	[3,1]	-1	hSpCas9	positive selection	4356414
68515416	68515439	17	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.14944668910911804	[2]	[1,1]	-3	hSpCas9	positive selection	4356415
68524056	68524079	17	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.3671476626043523	[4]	[4,3]	7	hSpCas9	positive selection	4356416
68522795	68522817	17	+	27760321	OCIAML3	viability	ACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-1.0787764155395418	[557,493]	[160,237]	-7	hSpCas9	negative selection	4430576
68522850	68522872	17	+	27760321	OCIAML3	viability	TTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-0.7856675803914184	[330,260]	[99,176]	-6	hSpCas9	negative selection	4430577
68522906	68522928	17	+	27760321	OCIAML3	viability	GCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	-0.8008682909109739	[376,282]	[109,194]	-6	hSpCas9	negative selection	4430578
68524045	68524067	17	-	27760321	OCIAML3	viability	ACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.002670983623748485	[425,330]	[244,358]	0	hSpCas9	negative selection	4430579
68524901	68524923	17	+	27760321	OCIAML3	viability	CCCTCTTTTAGGTGATGAAGGG	PRKAR1A	ENSG00000108946	-0.54798027573627	[125,102]	[53,69]	-5	hSpCas9	negative selection	4430580
68522795	68522817	17	+	27760321	OCIAML2	viability	ACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.7825675421567105	[557,493]	[192,317]	-7	hSpCas9	negative selection	4514039
68522850	68522872	17	+	27760321	OCIAML2	viability	TTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-1.1572631478211741	[330,260]	[91,125]	-8	hSpCas9	negative selection	4514040
68522906	68522928	17	+	27760321	OCIAML2	viability	GCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.09951923783675581	[376,282]	[255,319]	1	hSpCas9	negative selection	4514041
68524045	68524067	17	-	27760321	OCIAML2	viability	ACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	-0.43422082544162977	[425,330]	[221,228]	-5	hSpCas9	negative selection	4514042
68524901	68524923	17	+	27760321	OCIAML2	viability	CCCTCTTTTAGGTGATGAAGGG	PRKAR1A	ENSG00000108946	0.8689192686635243	[125,102]	[141,202]	9	hSpCas9	negative selection	4514043
68522795	68522817	17	+	27760321	MV411	viability	ACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-1.736423801111806	[557,493]	[95,115]	-8	hSpCas9	negative selection	4597502
68522850	68522872	17	+	27760321	MV411	viability	TTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-0.1463321200798804	[330,260]	[122,253]	-1	hSpCas9	negative selection	4597503
68522906	68522928	17	+	27760321	MV411	viability	GCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.464367855521258	[376,282]	[454,61]	3	hSpCas9	negative selection	4597504
68524045	68524067	17	-	27760321	MV411	viability	ACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	-1.748775161457095	[425,330]	[72,74]	-8	hSpCas9	negative selection	4597505
68524901	68524923	17	+	27760321	MV411	viability	CCCTCTTTTAGGTGATGAAGGG	PRKAR1A	ENSG00000108946	-0.7926285299981488	[125,102]	[46,37]	-5	hSpCas9	negative selection	4597506
68522795	68522817	17	+	27760321	HL60	viability	ACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-1.9274572819257738	[557,493]	[104,120]	-9	hSpCas9	negative selection	4680965
68522850	68522872	17	+	27760321	HL60	viability	TTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-1.6882497862132801	[330,260]	[42,107]	-9	hSpCas9	negative selection	4680966
68522906	68522928	17	+	27760321	HL60	viability	GCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	-0.3488356226621386	[376,282]	[255,160]	-4	hSpCas9	negative selection	4680967
68524045	68524067	17	-	27760321	HL60	viability	ACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	-0.3304794202699697	[425,330]	[232,255]	-4	hSpCas9	negative selection	4680968
68524901	68524923	17	+	27760321	HL60	viability	CCCTCTTTTAGGTGATGAAGGG	PRKAR1A	ENSG00000108946	0.873672379290169	[125,102]	[154,186]	8	hSpCas9	negative selection	4680969
68522795	68522817	17	+	27760321	HT1080	viability	ACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.7725249856242598	[493,385]	[83,122]	-3	hSpCas9	negative selection	4764428
68522850	68522872	17	+	27760321	HT1080	viability	TTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-5.970387312855003	[260,203]	[0,1]	-9	hSpCas9	negative selection	4764429
68522906	68522928	17	+	27760321	HT1080	viability	GCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	-3.208016649068118	[282,220]	[7,13]	-7	hSpCas9	negative selection	4764430
68524045	68524067	17	-	27760321	HT1080	viability	ACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	-0.8721507469955616	[330,257]	[65,61]	-4	hSpCas9	negative selection	4764431
68524901	68524923	17	+	27760321	HT1080	viability	CCCTCTTTTAGGTGATGAAGGG	PRKAR1A	ENSG00000108946	-0.06814527848126128	[102,80]	[44,23]	0	hSpCas9	negative selection	4764432
68522795	68522817	17	+	27760321	HT29	viability after 7 days	ACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	0.061062936179710925	[493,385]	[508,715,534]	0	hSpCas9	negative selection	4847891
68522850	68522872	17	+	27760321	HT29	viability after 7 days	TTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-0.4177637948437056	[260,203]	[273,268,137]	-6	hSpCas9	negative selection	4847892
68522906	68522928	17	+	27760321	HT29	viability after 7 days	GCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.34963957976178595	[282,220]	[524,506,227]	5	hSpCas9	negative selection	4847893
68524045	68524067	17	-	27760321	HT29	viability after 7 days	ACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.6689750448989615	[330,257]	[548,630,616]	8	hSpCas9	negative selection	4847894
68524901	68524923	17	+	27760321	HT29	viability after 7 days	CCCTCTTTTAGGTGATGAAGGG	PRKAR1A	ENSG00000108946	-0.40754100368597146	[102,80]	[141,73,59]	-5	hSpCas9	negative selection	4847895
68522795	68522817	17	+	27760321	HT29	viability after 25 days	ACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	0.45129434081286934	[493,385]	[619,705,745]	5	hSpCas9	negative selection	4931354
68522850	68522872	17	+	27760321	HT29	viability after 25 days	TTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-0.17629229720171846	[260,203]	[119,351,240]	-2	hSpCas9	negative selection	4931355
68522906	68522928	17	+	27760321	HT29	viability after 25 days	GCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.045148630771443765	[282,220]	[265,277,354]	0	hSpCas9	negative selection	4931356
68524045	68524067	17	-	27760321	HT29	viability after 25 days	ACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.36970736748756583	[330,257]	[296,679,323]	4	hSpCas9	negative selection	4931357
68524901	68524923	17	+	27760321	HT29	viability after 25 days	CCCTCTTTTAGGTGATGAAGGG	PRKAR1A	ENSG00000108946	0.32893771967365315	[102,80]	[45,176,183]	3	hSpCas9	negative selection	4931358
68522795	68522817	17	+	27760321	HT29	viability after 22 days	ACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	0.33898487522624365	[493,385]	[501,694,737]	3	hSpCas9	negative selection	5014817
68522850	68522872	17	+	27760321	HT29	viability after 22 days	TTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-0.43853892437684405	[260,203]	[119,189,287]	-4	hSpCas9	negative selection	5014818
68522906	68522928	17	+	27760321	HT29	viability after 22 days	GCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	-0.06110181305735052	[282,220]	[368,220,244]	0	hSpCas9	negative selection	5014819
68524045	68524067	17	-	27760321	HT29	viability after 22 days	ACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.3251307574422221	[330,257]	[319,567,393]	3	hSpCas9	negative selection	5014820
68524901	68524923	17	+	27760321	HT29	viability after 22 days	CCCTCTTTTAGGTGATGAAGGG	PRKAR1A	ENSG00000108946	0.2224954157255572	[102,80]	[21,145,207]	2	hSpCas9	negative selection	5014821
68522795	68522817	17	+	27760321	HT29	viability after 19 days	ACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	0.099701539426016	[493,385]	[675,369,583]	0	hSpCas9	negative selection	5098280
68522850	68522872	17	+	27760321	HT29	viability after 19 days	TTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-0.4101892327774066	[260,203]	[171,190,232]	-4	hSpCas9	negative selection	5098281
68522906	68522928	17	+	27760321	HT29	viability after 19 days	GCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	-0.6687478391243403	[282,220]	[198,174,171]	-5	hSpCas9	negative selection	5098282
68524045	68524067	17	-	27760321	HT29	viability after 19 days	ACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.36253329818386515	[330,257]	[387,365,535]	3	hSpCas9	negative selection	5098283
68524901	68524923	17	+	27760321	HT29	viability after 19 days	CCCTCTTTTAGGTGATGAAGGG	PRKAR1A	ENSG00000108946	1.2855107782497153	[102,80]	[94,300,352]	9	hSpCas9	negative selection	5098284
68522795	68522817	17	+	27760321	HT29	viability after 16 days	ACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	0.5086386998415701	[493,385]	[753,630,722]	6	hSpCas9	negative selection	5181743
68522850	68522872	17	+	27760321	HT29	viability after 16 days	TTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-0.15974908387667952	[260,203]	[270,316,111]	-2	hSpCas9	negative selection	5181744
68522906	68522928	17	+	27760321	HT29	viability after 16 days	GCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.03960649239385278	[282,220]	[411,93,379]	0	hSpCas9	negative selection	5181745
68524045	68524067	17	-	27760321	HT29	viability after 16 days	ACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.8319076873347819	[330,257]	[734,597,439]	8	hSpCas9	negative selection	5181746
68524901	68524923	17	+	27760321	HT29	viability after 16 days	CCCTCTTTTAGGTGATGAAGGG	PRKAR1A	ENSG00000108946	1.063897232736173	[102,80]	[108,244,280]	9	hSpCas9	negative selection	5181747
68522795	68522817	17	+	27760321	HT29	viability after 13 days	ACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	0.2526413045557162	[493,385]	[527,745,553]	3	hSpCas9	negative selection	5265206
68522850	68522872	17	+	27760321	HT29	viability after 13 days	TTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-1.007643443310923	[260,203]	[121,137,141]	-7	hSpCas9	negative selection	5265207
68522906	68522928	17	+	27760321	HT29	viability after 13 days	GCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.4572756315182891	[282,220]	[352,343,500]	6	hSpCas9	negative selection	5265208
68524045	68524067	17	-	27760321	HT29	viability after 13 days	ACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.7478864574451587	[330,257]	[505,672,543]	8	hSpCas9	negative selection	5265209
68524901	68524923	17	+	27760321	HT29	viability after 13 days	CCCTCTTTTAGGTGATGAAGGG	PRKAR1A	ENSG00000108946	1.019800720543468	[102,80]	[277,182,189]	9	hSpCas9	negative selection	5265210
68522795	68522817	17	+	27760321	HT29	viability after 10 days	ACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.0803435972887456	[493,385]	[867,426,266]	-1	hSpCas9	negative selection	5348669
68522850	68522872	17	+	27760321	HT29	viability after 10 days	TTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-0.0902281726674744	[260,203]	[271,250,293]	-1	hSpCas9	negative selection	5348670
68522906	68522928	17	+	27760321	HT29	viability after 10 days	GCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.19753479515812167	[282,220]	[324,388,368]	2	hSpCas9	negative selection	5348671
68524045	68524067	17	-	27760321	HT29	viability after 10 days	ACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.22870349170386292	[330,257]	[353,516,423]	3	hSpCas9	negative selection	5348672
68524901	68524923	17	+	27760321	HT29	viability after 10 days	CCCTCTTTTAGGTGATGAAGGG	PRKAR1A	ENSG00000108946	0.6633686477473164	[102,80]	[210,128,203]	8	hSpCas9	negative selection	5348673
68522795	68522817	17	+	27760321	MOLM13	viability	ACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-1.87645486177566	[557,493]	[57,99]	-7	hSpCas9	negative selection	5432132
68522850	68522872	17	+	27760321	MOLM13	viability	TTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-1.6733704113307613	[330,260]	[44,57]	-7	hSpCas9	negative selection	5432133
68522906	68522928	17	+	27760321	MOLM13	viability	GCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	-0.7204568960591919	[376,282]	[23,186]	-4	hSpCas9	negative selection	5432134
68524045	68524067	17	-	27760321	MOLM13	viability	ACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	-1.173203230755989	[425,330]	[59,122]	-6	hSpCas9	negative selection	5432135
68524901	68524923	17	+	27760321	MOLM13	viability	CCCTCTTTTAGGTGATGAAGGG	PRKAR1A	ENSG00000108946	-0.18452650083732514	[125,102]	[48,62]	-1	hSpCas9	negative selection	5432136
68512439	68512462	17	+	27661255	K562	viability	GCCTAGCCGCTATCGCAGAGTGG	PRKAR1A	ENSG00000108946	0.044804745311524063	[538,553]	[529,381]	1	dCas9-KRAB	negative selection	5504130
68512444	68512467	17	+	27661255	K562	viability	GCCGCTATCGCAGAGTGGAGCGG	PRKAR1A	ENSG00000108946	0.26748634274601235	[432,546]	[547,401]	8	dCas9-KRAB	negative selection	5504131
68512872	68512895	17	-	27661255	K562	viability	GAGGGTGAGCGAAGAGGCCGCGG	PRKAR1A	ENSG00000108946	0.3890390602743311	[739,710]	[766,752]	9	dCas9-KRAB	negative selection	5504132
68515408	68515431	17	+	27260156	BXPC3	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.02830069958462217	[589]	[628,553,562,677]	0	hSpCas9	negative selection	5564616
68522794	68522817	17	+	27260156	BXPC3	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	0.05551725124739049	[82]	[53,111,90,107]	1	hSpCas9	negative selection	5564617
68522905	68522928	17	+	27260156	BXPC3	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.047081662019425874	[71]	[52,61,72,132]	1	hSpCas9	negative selection	5564618
68524045	68524068	17	-	27260156	BXPC3	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.22211060676062278	[693]	[883,696,994,805]	5	hSpCas9	negative selection	5628874
68515416	68515439	17	-	27260156	BXPC3	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.4521571230497932	[352]	[497,432,509,590]	8	hSpCas9	negative selection	5628875
68524056	68524079	17	+	27260156	BXPC3	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.13070656373282508	[1170]	[1360,1261,1215,1537]	3	hSpCas9	negative selection	5628876
68515408	68515431	17	+	27260156	A673	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.0943232026250986	[589]	[715,609,647,687]	-2	hSpCas9	negative selection	5685867
68522794	68522817	17	+	27260156	A673	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	0.0062882976686902126	[82]	[110,71,118,99]	0	hSpCas9	negative selection	5685868
68522905	68522928	17	+	27260156	A673	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.3851018361953069	[71]	[131,110,79,131]	8	hSpCas9	negative selection	5685869
68524045	68524068	17	-	27260156	A673	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.11565666671479935	[693]	[974,872,868,901]	2	hSpCas9	negative selection	5750125
68515416	68515439	17	-	27260156	A673	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.3216187013821329	[352]	[472,623,455,557]	7	hSpCas9	negative selection	5750126
68524056	68524079	17	+	27260156	A673	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.13748016357727644	[1170]	[1657,1423,1530,1588]	3	hSpCas9	negative selection	5750127
68515408	68515431	17	+	27260156	A375	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.08847975624973797	[589]	[582,906,713,445]	-1	hSpCas9	negative selection	5807118
68522794	68522817	17	+	27260156	A375	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-1.2209290466614857	[82]	[24,62,38,41]	-8	hSpCas9	negative selection	5807119
68522905	68522928	17	+	27260156	A375	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.5203455627120177	[71]	[170,70,126,107]	7	hSpCas9	negative selection	5807120
68524045	68524068	17	-	27260156	A375	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.36276118777988886	[693]	[1137,1258,968,852]	5	hSpCas9	negative selection	5871376
68515416	68515439	17	-	27260156	A375	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.23396557588747496	[352]	[413,490,621,418]	3	hSpCas9	negative selection	5871377
68524056	68524079	17	+	27260156	A375	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.5103135391368119	[1170]	[1985,2457,1823,1626]	7	hSpCas9	negative selection	5871378
68515408	68515431	17	+	27260156	COLO741	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-1.8218958841934814	[589]	[307,194,148]	-9	hSpCas9	negative selection	5928369
68522794	68522817	17	+	27260156	COLO741	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	0.2176644666677543	[82]	[94,199,75]	4	hSpCas9	negative selection	5928370
68522905	68522928	17	+	27260156	COLO741	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.5309378994749538	[71]	[157,129,113]	9	hSpCas9	negative selection	5928371
68524045	68524068	17	-	27260156	COLO741	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	-0.01986278461120372	[693]	[949,871,810]	0	hSpCas9	negative selection	5992627
68515416	68515439	17	-	27260156	COLO741	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-1.5171824616335927	[352]	[119,187,160]	-9	hSpCas9	negative selection	5992628
68524056	68524079	17	+	27260156	COLO741	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.2254141639258207	[1170]	[1950,1832,1495]	5	hSpCas9	negative selection	5992629
68515408	68515431	17	+	27260156	CAL120	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.02736252262165756	[589]	[727,711,721]	0	hSpCas9	negative selection	6049620
68522794	68522817	17	+	27260156	CAL120	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.37751620670146036	[82]	[17,174,36]	-5	hSpCas9	negative selection	6049621
68522905	68522928	17	+	27260156	CAL120	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.7549164623633102	[71]	[188,162,107]	9	hSpCas9	negative selection	6049622
68524045	68524068	17	-	27260156	CAL120	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.13560372663258036	[693]	[980,830,1036]	2	hSpCas9	negative selection	6113878
68515416	68515439	17	-	27260156	CAL120	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.15754923501282464	[352]	[254,431,471]	-2	hSpCas9	negative selection	6113879
68524056	68524079	17	+	27260156	CAL120	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	-0.07130313101152486	[1170]	[1057,1404,1642]	-1	hSpCas9	negative selection	6113880
68515408	68515431	17	+	27260156	CADOES1	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	0.17230384806235238	[589]	[600,661,528,683]	3	hSpCas9	negative selection	6170871
68522794	68522817	17	+	27260156	CADOES1	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-1.1222887754049702	[82]	[24,18,57,39]	-9	hSpCas9	negative selection	6170872
68522905	68522928	17	+	27260156	CADOES1	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.31301773391512544	[71]	[54,146,97,30]	5	hSpCas9	negative selection	6170873
68524045	68524068	17	-	27260156	CADOES1	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.11787597074669309	[693]	[738,500,633,935]	2	hSpCas9	negative selection	6235129
68515416	68515439	17	-	27260156	CADOES1	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.000920355303543452	[352]	[243,337,283,452]	0	hSpCas9	negative selection	6235130
68524056	68524079	17	+	27260156	CADOES1	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.3455072020126104	[1170]	[1572,1253,1335,1370]	6	hSpCas9	negative selection	6235131
68515408	68515431	17	+	27260156	EWS502	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.1118495236293928	[589]	[636,425,722,521]	-2	hSpCas9	negative selection	6292122
68522794	68522817	17	+	27260156	EWS502	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.6169916408181599	[82]	[54,82,63,23]	-7	hSpCas9	negative selection	6292123
68522905	68522928	17	+	27260156	EWS502	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.33488887689324587	[71]	[79,116,50,139]	6	hSpCas9	negative selection	6292124
68524045	68524068	17	-	27260156	EWS502	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.08209141509097784	[693]	[761,664,829,865]	1	hSpCas9	negative selection	6356380
68515416	68515439	17	-	27260156	EWS502	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.010329171320039965	[352]	[229,393,329,581]	0	hSpCas9	negative selection	6356381
68524056	68524079	17	+	27260156	EWS502	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.11256401185990006	[1170]	[1241,1400,1235,1498]	2	hSpCas9	negative selection	6356382
68515408	68515431	17	+	27260156	EW8	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.2945010635254192	[589]	[422,474,273,409]	-5	hSpCas9	negative selection	6413373
68522794	68522817	17	+	27260156	EW8	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.3113361187110164	[82]	[66,55,36,60]	-5	hSpCas9	negative selection	6413374
68522905	68522928	17	+	27260156	EW8	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.4446769212422308	[71]	[16,85,93,110]	7	hSpCas9	negative selection	6413375
68524045	68524068	17	-	27260156	EW8	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	-0.07753519854526525	[693]	[483,501,560,572]	-1	hSpCas9	negative selection	6477631
68515416	68515439	17	-	27260156	EW8	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.28071234220278046	[352]	[305,306,239,548]	5	hSpCas9	negative selection	6477632
68524056	68524079	17	+	27260156	EW8	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.1403317341889856	[1170]	[1361,1145,794,955]	2	hSpCas9	negative selection	6477633
68515408	68515431	17	+	27260156	CORL105	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	0.16664214595623367	[589]	[726,774,1137,516]	3	hSpCas9	negative selection	6534624
68522794	68522817	17	+	27260156	CORL105	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.4602631476533361	[82]	[74,92,49,60]	-7	hSpCas9	negative selection	6534625
68522905	68522928	17	+	27260156	CORL105	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	-0.2675526620376516	[71]	[75,41,52,106]	-5	hSpCas9	negative selection	6534626
68524045	68524068	17	-	27260156	CORL105	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	-0.009062885909679186	[693]	[827,746,1007,679]	0	hSpCas9	negative selection	6598882
68515416	68515439	17	-	27260156	CORL105	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.07086796968176451	[352]	[339,466,346,408]	-1	hSpCas9	negative selection	6598883
68524056	68524079	17	+	27260156	CORL105	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.19535186469241217	[1170]	[1375,1628,1802,1498]	3	hSpCas9	negative selection	6598884
68515408	68515431	17	+	27260156	HS294T	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	0.34857470666584206	[589]	[220,336,267,349]	5	hSpCas9	negative selection	6655875
68522794	68522817	17	+	27260156	HS294T	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-1.1661220240941312	[82]	[7,10,18,20]	-9	hSpCas9	negative selection	6655876
68522905	68522928	17	+	27260156	HS294T	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	-0.2721428579194427	[71]	[18,13,25,35]	-4	hSpCas9	negative selection	6655877
68524045	68524068	17	-	27260156	HS294T	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.138452569525655	[693]	[302,294,364,200]	2	hSpCas9	negative selection	6720133
68515416	68515439	17	-	27260156	HS294T	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.07215677871209575	[352]	[125,166,119,99]	-1	hSpCas9	negative selection	6720134
68524056	68524079	17	+	27260156	HS294T	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.329457750815205	[1170]	[413,710,589,568]	4	hSpCas9	negative selection	6720135
68515408	68515431	17	+	27260156	HCC44	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	0.14272113172083534	[589]	[951,985,608,367]	2	hSpCas9	negative selection	6777126
68522794	68522817	17	+	27260156	HCC44	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.3095991644031053	[82]	[1,56,208,53]	-5	hSpCas9	negative selection	6777127
68522905	68522928	17	+	27260156	HCC44	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.29111675680987714	[71]	[113,38,59,184]	5	hSpCas9	negative selection	6777128
68524045	68524068	17	-	27260156	HCC44	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.2769572837085732	[693]	[999,1109,927,742]	4	hSpCas9	negative selection	6841384
68515416	68515439	17	-	27260156	HCC44	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.08704825988159931	[352]	[616,326,501,295]	1	hSpCas9	negative selection	6841385
68524056	68524079	17	+	27260156	HCC44	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.16915677874583257	[1170]	[1639,1256,1501,1590]	2	hSpCas9	negative selection	6841386
68515408	68515431	17	+	27260156	G402	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.21277321133346488	[589]	[662,1052,355,449]	-3	hSpCas9	negative selection	6898377
68522794	68522817	17	+	27260156	G402	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-1.2304892739425703	[82]	[42,56,66,7]	-8	hSpCas9	negative selection	6898378
68522905	68522928	17	+	27260156	G402	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	1.1916796109818892	[71]	[175,94,103,406]	9	hSpCas9	negative selection	6898379
68524045	68524068	17	-	27260156	G402	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.2761501169975763	[693]	[1121,1228,881,896]	3	hSpCas9	negative selection	6962635
68515416	68515439	17	-	27260156	G402	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.2594423030156401	[352]	[521,714,555,290]	3	hSpCas9	negative selection	6962636
68524056	68524079	17	+	27260156	G402	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.39703959053247684	[1170]	[1965,1689,1900,1958]	5	hSpCas9	negative selection	6962637
68515408	68515431	17	+	27260156	L33	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	0.14836005305325234	[589]	[584,300,371,704]	3	hSpCas9	negative selection	7019628
68522794	68522817	17	+	27260156	L33	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.1887110291163121	[82]	[73,17,36,113]	-4	hSpCas9	negative selection	7019629
68522905	68522928	17	+	27260156	L33	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.6703816462354499	[71]	[54,43,89,153]	9	hSpCas9	negative selection	7019630
68524045	68524068	17	-	27260156	L33	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	-0.1593069812658403	[693]	[565,295,332,667]	-4	hSpCas9	negative selection	7083886
68515416	68515439	17	-	27260156	L33	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.13887928202199118	[352]	[430,135,277,348]	3	hSpCas9	negative selection	7083887
68524056	68524079	17	+	27260156	L33	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.028574617166686522	[1170]	[1083,453,853,1229]	0	hSpCas9	negative selection	7083888
68515408	68515431	17	+	27260156	K562	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	0.11222157927410742	[589]	[462,526,950,336]	1	hSpCas9	negative selection	7140879
68522794	68522817	17	+	27260156	K562	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	0.9045065339849898	[82]	[34,24,304,167]	9	hSpCas9	negative selection	7140880
68522905	68522928	17	+	27260156	K562	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.47823842464069877	[71]	[57,123,140,37]	6	hSpCas9	negative selection	7140881
68524045	68524068	17	-	27260156	K562	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.16654091148434902	[693]	[846,700,627,608]	2	hSpCas9	negative selection	7205137
68515416	68515439	17	-	27260156	K562	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.4824158142662792	[352]	[402,520,734,127]	6	hSpCas9	negative selection	7205138
68524056	68524079	17	+	27260156	K562	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.39712933022608743	[1170]	[1165,1202,1197,1821]	5	hSpCas9	negative selection	7205139
68515408	68515431	17	+	27260156	HT29	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.04400472803421984	[589]	[740,779,577,689]	-1	hSpCas9	negative selection	7262130
68522794	68522817	17	+	27260156	HT29	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	0.2146287033921097	[82]	[126,135,126,83]	4	hSpCas9	negative selection	7262131
68522905	68522928	17	+	27260156	HT29	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	-0.12500859882840842	[71]	[108,106,64,47]	-3	hSpCas9	negative selection	7262132
68524045	68524068	17	-	27260156	HT29	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.16742843733769308	[693]	[901,1187,905,819]	3	hSpCas9	negative selection	7326388
68515416	68515439	17	-	27260156	HT29	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.08365902389906488	[352]	[456,434,367,542]	1	hSpCas9	negative selection	7326389
68524056	68524079	17	+	27260156	HT29	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.21200607297409113	[1170]	[1775,1686,1535,1602]	4	hSpCas9	negative selection	7326390
68515408	68515431	17	+	27260156	MHHES1	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.3693431134591783	[589]	[619,551,408,486]	-6	hSpCas9	negative selection	7383381
68522794	68522817	17	+	27260156	MHHES1	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.03971048874891636	[82]	[38,42,111,143]	0	hSpCas9	negative selection	7383382
68522905	68522928	17	+	27260156	MHHES1	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.5680688443045279	[71]	[150,166,173,18]	8	hSpCas9	negative selection	7383383
68524045	68524068	17	-	27260156	MHHES1	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.17518753390941	[693]	[1016,826,855,831]	3	hSpCas9	negative selection	7447639
68515416	68515439	17	-	27260156	MHHES1	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.2597338706037066	[352]	[544,588,470,339]	5	hSpCas9	negative selection	7447640
68524056	68524079	17	+	27260156	MHHES1	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.07313458512982707	[1170]	[1365,1538,1377,1273]	1	hSpCas9	negative selection	7447641
68515408	68515431	17	+	27260156	MEWO	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.5014410500030079	[589]	[432,393,350]	-8	hSpCas9	negative selection	7504632
68522794	68522817	17	+	27260156	MEWO	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.5521542437321818	[82]	[79,73,9]	-8	hSpCas9	negative selection	7504633
68522905	68522928	17	+	27260156	MEWO	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.3460955093727005	[71]	[116,70,74]	7	hSpCas9	negative selection	7504634
68524045	68524068	17	-	27260156	MEWO	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	-0.30404822130575976	[693]	[508,589,474]	-6	hSpCas9	negative selection	7568890
68515416	68515439	17	-	27260156	MEWO	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.6562932736954903	[352]	[272,186,180]	-8	hSpCas9	negative selection	7568891
68524056	68524079	17	+	27260156	MEWO	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	-0.04791072954377862	[1170]	[1180,962,1058]	-1	hSpCas9	negative selection	7568892
68515408	68515431	17	+	27260156	LNCAPCLONEFGC	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.06459182241115496	[589]	[499,375,638,556]	-1	hSpCas9	negative selection	7625883
68522794	68522817	17	+	27260156	LNCAPCLONEFGC	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-1.2631986686053014	[82]	[9,21,35,58]	-9	hSpCas9	negative selection	7625884
68522905	68522928	17	+	27260156	LNCAPCLONEFGC	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.38516565173930095	[71]	[53,42,104,144]	6	hSpCas9	negative selection	7625885
68524045	68524068	17	-	27260156	LNCAPCLONEFGC	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.3577461084787704	[693]	[852,825,1064,513]	5	hSpCas9	negative selection	7690141
68515416	68515439	17	-	27260156	LNCAPCLONEFGC	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.09630105034877129	[352]	[238,206,463,317]	-1	hSpCas9	negative selection	7690142
68524056	68524079	17	+	27260156	LNCAPCLONEFGC	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.2861346815842907	[1170]	[1312,1384,1215,1240]	4	hSpCas9	negative selection	7690143
68515408	68515431	17	+	27260156	PANC0327	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.5749237521332174	[589]	[427,322,245,419]	-7	hSpCas9	negative selection	7747134
68522794	68522817	17	+	27260156	PANC0327	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-1.6539658090973024	[82]	[28,39,5,16]	-9	hSpCas9	negative selection	7747135
68522905	68522928	17	+	27260156	PANC0327	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	-0.07151501482008937	[71]	[100,12,102,35]	-1	hSpCas9	negative selection	7747136
68524045	68524068	17	-	27260156	PANC0327	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	-0.04301180304153884	[693]	[712,478,547,677]	0	hSpCas9	negative selection	7811392
68515416	68515439	17	-	27260156	PANC0327	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.4332265031016179	[352]	[306,662,375,306]	6	hSpCas9	negative selection	7811393
68524056	68524079	17	+	27260156	PANC0327	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.28523181289569544	[1170]	[2047,1055,987,1068]	4	hSpCas9	negative selection	7811394
68515408	68515431	17	+	27260156	NCIH2009	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	0.1681188934699373	[589]	[903,1071,793]	2	hSpCas9	negative selection	7868385
68522794	68522817	17	+	27260156	NCIH2009	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.8589423286520557	[82]	[97,87,11]	-8	hSpCas9	negative selection	7868386
68522905	68522928	17	+	27260156	NCIH2009	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	-0.1419812239949909	[71]	[101,117,54]	-2	hSpCas9	negative selection	7868387
68524045	68524068	17	-	27260156	NCIH2009	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.305228762985318	[693]	[1492,1005,1154]	4	hSpCas9	negative selection	7932643
68515416	68515439	17	-	27260156	NCIH2009	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.11144784070312141	[352]	[820,503,329]	1	hSpCas9	negative selection	7932644
68524056	68524079	17	+	27260156	NCIH2009	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.23051500749355713	[1170]	[2246,1866,1706]	3	hSpCas9	negative selection	7932645
68515408	68515431	17	+	27260156	NCIH1373	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	0.4846969190819402	[589]	[548,563,654,519]	5	hSpCas9	negative selection	7989636
68522794	68522817	17	+	27260156	NCIH1373	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-1.479768972541434	[82]	[42,41,21,6]	-9	hSpCas9	negative selection	7989637
68522905	68522928	17	+	27260156	NCIH1373	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	1.1086982257197384	[71]	[98,477,29,9]	9	hSpCas9	negative selection	7989638
68524045	68524068	17	-	27260156	NCIH1373	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.6054862245228949	[693]	[1261,956,1550,255]	6	hSpCas9	negative selection	8053894
68515416	68515439	17	-	27260156	NCIH1373	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.2216063047495353	[352]	[372,212,310,127]	-2	hSpCas9	negative selection	8053895
68524056	68524079	17	+	27260156	NCIH1373	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.44295063275778257	[1170]	[1998,1389,2465,342]	4	hSpCas9	negative selection	8053896
68515408	68515431	17	+	27260156	PATU8902	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	0.2872635137383522	[589]	[1001,1061,582,1527]	3	hSpCas9	negative selection	8110887
68522794	68522817	17	+	27260156	PATU8902	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.6604995282423416	[82]	[84,56,61,92]	-6	hSpCas9	negative selection	8110888
68522905	68522928	17	+	27260156	PATU8902	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	1.4892449037561273	[71]	[303,170,143,574]	9	hSpCas9	negative selection	8110889
68524045	68524068	17	-	27260156	PATU8902	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.28504398122528074	[693]	[667,2072,927,1096]	3	hSpCas9	negative selection	8175145
68515416	68515439	17	-	27260156	PATU8902	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.5206180950452497	[352]	[538,253,253,340]	-5	hSpCas9	negative selection	8175146
68524056	68524079	17	+	27260156	PATU8902	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.5365824327977973	[1170]	[2831,2842,1544,2440]	5	hSpCas9	negative selection	8175147
68515408	68515431	17	+	27260156	PANC1	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	0.013944640717057588	[589]	[360,885,595,309]	0	hSpCas9	negative selection	8232138
68522794	68522817	17	+	27260156	PANC1	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-1.4350746638472258	[82]	[26,33,28,17]	-9	hSpCas9	negative selection	8232139
68522905	68522928	17	+	27260156	PANC1	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.61810746437859	[71]	[74,68,117,108]	8	hSpCas9	negative selection	8232140
68524045	68524068	17	-	27260156	PANC1	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.2356134489331826	[693]	[558,846,729,693]	4	hSpCas9	negative selection	8296396
68515416	68515439	17	-	27260156	PANC1	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.3355116098875538	[352]	[351,401,473,312]	5	hSpCas9	negative selection	8296397
68524056	68524079	17	+	27260156	PANC1	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.2868111419902588	[1170]	[1156,1338,1409,1038]	4	hSpCas9	negative selection	8296398
68515408	68515431	17	+	27260156	PANC0813	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	0.16769873696846227	[589]	[816,813,658,822]	2	hSpCas9	negative selection	8353389
68522794	68522817	17	+	27260156	PANC0813	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.7191070902615673	[82]	[113,17,35,72]	-7	hSpCas9	negative selection	8353390
68522905	68522928	17	+	27260156	PANC0813	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.0774476813297289	[71]	[47,132,100,71]	1	hSpCas9	negative selection	8353391
68524045	68524068	17	-	27260156	PANC0813	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.19475002531382835	[693]	[1144,910,840,856]	3	hSpCas9	negative selection	8417647
68515416	68515439	17	-	27260156	PANC0813	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.45253383948687326	[352]	[677,572,623,412]	7	hSpCas9	negative selection	8417648
68524056	68524079	17	+	27260156	PANC0813	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.13099296371481128	[1170]	[1832,1221,1563,1437]	2	hSpCas9	negative selection	8417649
68515408	68515431	17	+	27260156	RDES	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.17415575744491066	[589]	[415,634,704,685]	-3	hSpCas9	negative selection	8474640
68522794	68522817	17	+	27260156	RDES	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.03839001230724248	[82]	[54,84,106,138]	0	hSpCas9	negative selection	8474641
68522905	68522928	17	+	27260156	RDES	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.4902332769535098	[71]	[96,81,121,177]	7	hSpCas9	negative selection	8474642
68524045	68524068	17	-	27260156	RDES	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.11846797989024171	[693]	[657,870,1004,971]	2	hSpCas9	negative selection	8538898
68515416	68515439	17	-	27260156	RDES	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.16175051951963693	[352]	[309,431,564,548]	2	hSpCas9	negative selection	8538899
68524056	68524079	17	+	27260156	RDES	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.2772849133491928	[1170]	[1245,1625,1794,1951]	4	hSpCas9	negative selection	8538900
68515408	68515431	17	+	27260156	PC3	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.21360387265528788	[589]	[359,588,559,544]	-5	hSpCas9	negative selection	8595891
68522794	68522817	17	+	27260156	PC3	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.06327763198757985	[82]	[15,59,173,131]	-1	hSpCas9	negative selection	8595892
68522905	68522928	17	+	27260156	PC3	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.8061262958670075	[71]	[86,105,173,159]	9	hSpCas9	negative selection	8595893
68524045	68524068	17	-	27260156	PC3	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.07553044054070257	[693]	[467,707,1268,723]	1	hSpCas9	negative selection	8660149
68515416	68515439	17	-	27260156	PC3	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.17611821085371088	[352]	[188,259,481,412]	-4	hSpCas9	negative selection	8660150
68524056	68524079	17	+	27260156	PC3	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.1732523864593687	[1170]	[836,1165,2285,1448]	4	hSpCas9	negative selection	8660151
68515408	68515431	17	+	27260156	PATU8988T	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	0.12863969065474024	[589]	[534,672,568,729]	2	hSpCas9	negative selection	8717142
68522794	68522817	17	+	27260156	PATU8988T	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.004517638586363226	[82]	[57,41,100,117]	0	hSpCas9	negative selection	8717143
68522905	68522928	17	+	27260156	PATU8988T	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.07565455599379911	[71]	[22,107,152,5]	1	hSpCas9	negative selection	8717144
68524045	68524068	17	-	27260156	PATU8988T	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.051225296786936325	[693]	[527,824,603,847]	0	hSpCas9	negative selection	8781400
68515416	68515439	17	-	27260156	PATU8988T	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.21844035366891862	[352]	[650,348,235,344]	4	hSpCas9	negative selection	8781401
68524056	68524079	17	+	27260156	PATU8988T	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.31526144481485274	[1170]	[1629,1344,1124,1539]	5	hSpCas9	negative selection	8781402
68515408	68515431	17	+	27260156	T47D	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.13123217103519236	[589]	[575,646,691,590]	-3	hSpCas9	negative selection	8838393
68522794	68522817	17	+	27260156	T47D	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.08964922323713331	[82]	[105,100,85,68]	-2	hSpCas9	negative selection	8838394
68522905	68522928	17	+	27260156	T47D	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.0653025020637723	[71]	[130,58,73,89]	1	hSpCas9	negative selection	8838395
68524045	68524068	17	-	27260156	T47D	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.10945274116318504	[693]	[885,856,832,915]	2	hSpCas9	negative selection	8902651
68515416	68515439	17	-	27260156	T47D	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.32014033295028654	[352]	[479,564,514,487]	6	hSpCas9	negative selection	8902652
68524056	68524079	17	+	27260156	T47D	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.15782284978006955	[1170]	[1418,1274,1813,1597]	3	hSpCas9	negative selection	8902653
68515408	68515431	17	+	27260156	SU8686	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	0.07252290619487561	[589]	[598,442,735,722]	1	hSpCas9	negative selection	8959644
68522794	68522817	17	+	27260156	SU8686	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	0.16995176136996548	[82]	[64,146,39,115]	3	hSpCas9	negative selection	8959645
68522905	68522928	17	+	27260156	SU8686	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.41097888449579933	[71]	[92,79,73,140]	7	hSpCas9	negative selection	8959646
68524045	68524068	17	-	27260156	SU8686	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.05588950021896211	[693]	[730,493,756,937]	0	hSpCas9	negative selection	9023902
68515416	68515439	17	-	27260156	SU8686	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.1951942773772984	[352]	[292,384,426,530]	3	hSpCas9	negative selection	9023903
68524056	68524079	17	+	27260156	SU8686	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.022026787860499386	[1170]	[1062,1057,1441,1179]	0	hSpCas9	negative selection	9023904
68515408	68515431	17	+	27260156	SKES1	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.09644457928244804	[589]	[687,540,471,517]	-2	hSpCas9	negative selection	9080895
68522794	68522817	17	+	27260156	SKES1	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.1466594200836009	[82]	[76,95,37,88]	-3	hSpCas9	negative selection	9080896
68522905	68522928	17	+	27260156	SKES1	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.4943116335818667	[71]	[101,143,161,10]	8	hSpCas9	negative selection	9080897
68524045	68524068	17	-	27260156	SKES1	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.1559385197252272	[693]	[903,946,692,594]	3	hSpCas9	negative selection	9145153
68515416	68515439	17	-	27260156	SKES1	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.019697744218378666	[352]	[327,448,329,327]	0	hSpCas9	negative selection	9145154
68524056	68524079	17	+	27260156	SKES1	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.05555344385833472	[1170]	[1121,1506,1170,1081]	1	hSpCas9	negative selection	9145155
68515408	68515431	17	+	27260156	TOV112D	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	0.2835890938333215	[589]	[661,728,854,629]	5	hSpCas9	negative selection	9202146
68522794	68522817	17	+	27260156	TOV112D	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	1.1815211582088285	[82]	[415,188,82,87]	9	hSpCas9	negative selection	9202147
68522905	68522928	17	+	27260156	TOV112D	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.28832737168642764	[71]	[78,64,52,146]	5	hSpCas9	negative selection	9202148
68524045	68524068	17	-	27260156	TOV112D	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	-0.13879749763000415	[693]	[603,586,578,737]	-3	hSpCas9	negative selection	9266404
68515416	68515439	17	-	27260156	TOV112D	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.441217193817564	[352]	[360,891,397,362]	7	hSpCas9	negative selection	9266405
68524056	68524079	17	+	27260156	TOV112D	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.543546334212756	[1170]	[2094,1793,1318,1680]	8	hSpCas9	negative selection	9266406
68515408	68515431	17	+	27260156	TC71	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.06963344559008988	[589]	[608,654,567,577]	-2	hSpCas9	negative selection	9323397
68522794	68522817	17	+	27260156	TC71	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.39836638450461326	[82]	[35,63,77,93]	-8	hSpCas9	negative selection	9323398
68522905	68522928	17	+	27260156	TC71	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	0.4003614282869461	[71]	[66,137,73,131]	8	hSpCas9	negative selection	9323399
68524045	68524068	17	-	27260156	TC71	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	-0.13360708238064917	[693]	[671,714,643,682]	-3	hSpCas9	negative selection	9387655
68515416	68515439	17	-	27260156	TC71	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.34945235659151286	[352]	[515,392,473,548]	8	hSpCas9	negative selection	9387656
68524056	68524079	17	+	27260156	TC71	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.09495493052361348	[1170]	[1470,1419,1216,1249]	2	hSpCas9	negative selection	9387657
68515408	68515431	17	+	27260156	TC32	viability	TGGCAGTACCGCCGCCAGTGAGG	PRKAR1A	ENSG00000108946	-0.21184072707029805	[589]	[418,461,466,551]	-4	hSpCas9	negative selection	9444648
68522794	68522817	17	+	27260156	TC32	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.2677893357346002	[82]	[36,105,62,33]	-5	hSpCas9	negative selection	9444649
68522905	68522928	17	+	27260156	TC32	viability	TGCGGCATCCTATGTTAGAAAGG	PRKAR1A	ENSG00000108946	-0.3823367089808243	[71]	[47,1,122,64]	-6	hSpCas9	negative selection	9444650
68524045	68524068	17	-	27260156	TC32	viability	CACAGTCTCTCCTGCGATAAAGG	PRKAR1A	ENSG00000108946	0.016720261407110693	[693]	[648,363,981,783]	0	hSpCas9	negative selection	9508906
68515416	68515439	17	-	27260156	TC32	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.003033570736898361	[352]	[351,212,492,315]	0	hSpCas9	negative selection	9508907
68524056	68524079	17	+	27260156	TC32	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.2763820556947212	[1170]	[1582,775,1751,1396]	5	hSpCas9	negative selection	9508908
68515411	68515434	17	+	27869803	HPAFII	viability after 27 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	-0.29894872976895454	[253]	[71,138,NaN]	-2	hSpCas9	negative selection	9562546
68522843	68522866	17	-	27869803	HPAFII	viability after 27 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	0.6617021258863633	[396]	[495,191,NaN]	5	hSpCas9	negative selection	9562547
68522878	68522901	17	+	27869803	HPAFII	viability after 27 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-0.7054072499796602	[546]	[39,289,NaN]	-5	hSpCas9	negative selection	9562548
68528864	68528887	17	+	27869803	HPAFII	viability after 27 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	0.27143026320958524	[303]	[241,151,NaN]	2	hSpCas9	negative selection	9562549
68528917	68528940	17	-	27869803	HPAFII	viability after 27 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	0.4691128819091862	[186]	[20,231,NaN]	4	hSpCas9	negative selection	9562550
68530303	68530326	17	-	27869803	HPAFII	viability after 27 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	-0.4893265476150366	[233]	[79,93,NaN]	-4	hSpCas9	negative selection	9562551
68515411	68515434	17	+	27869803	HPAFII	viability after 15 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	-0.5422656802355478	[253]	[229,160,NaN]	-5	hSpCas9	negative selection	9644995
68522843	68522866	17	-	27869803	HPAFII	viability after 15 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	0.5226448751323072	[396]	[911,426,NaN]	6	hSpCas9	negative selection	9644996
68522878	68522901	17	+	27869803	HPAFII	viability after 15 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-0.198236681922615	[546]	[541,493,NaN]	-2	hSpCas9	negative selection	9644997
68528864	68528887	17	+	27869803	HPAFII	viability after 15 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	0.7983523269090851	[303]	[1087,244,NaN]	8	hSpCas9	negative selection	9644998
68528917	68528940	17	-	27869803	HPAFII	viability after 15 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	0.8616099981784366	[186]	[194,470,NaN]	8	hSpCas9	negative selection	9644999
68530303	68530326	17	-	27869803	HPAFII	viability after 15 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	0.24234687876007585	[233]	[167,377,NaN]	2	hSpCas9	negative selection	9645000
68515411	68515434	17	+	27869803	ASPC1	viability after 36 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	1.545871081542462	[501]	[180,419,810]	9	hSpCas9	negative selection	9727444
68522843	68522866	17	-	27869803	ASPC1	viability after 36 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	0.0756346475929327	[1105]	[261,522,411]	0	hSpCas9	negative selection	9727445
68522878	68522901	17	+	27869803	ASPC1	viability after 36 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-0.8076900944889891	[1533]	[166,518,230]	-7	hSpCas9	negative selection	9727446
68528864	68528887	17	+	27869803	ASPC1	viability after 36 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	0.14671750288327534	[793]	[257,642,70]	1	hSpCas9	negative selection	9727447
68528917	68528940	17	-	27869803	ASPC1	viability after 36 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	1.0590846259821358	[516]	[581,309,279]	8	hSpCas9	negative selection	9727448
68530303	68530326	17	-	27869803	ASPC1	viability after 36 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	-0.18907940851426477	[573]	[133,369,48]	-2	hSpCas9	negative selection	9727449
68515411	68515434	17	+	27869803	PATU8988S	viability after 35 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	-0.13759771416753974	[451]	[157,172,NaN]	-1	hSpCas9	negative selection	9809893
68522843	68522866	17	-	27869803	PATU8988S	viability after 35 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	0.10647279708019097	[1049]	[576,332,NaN]	1	hSpCas9	negative selection	9809894
68522878	68522901	17	+	27869803	PATU8988S	viability after 35 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	0.36335188102918203	[1422]	[850,622,NaN]	4	hSpCas9	negative selection	9809895
68528864	68528887	17	+	27869803	PATU8988S	viability after 35 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	-0.041775934770271556	[660]	[310,205,NaN]	0	hSpCas9	negative selection	9809896
68528917	68528940	17	-	27869803	PATU8988S	viability after 35 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	1.7900413307389953	[407]	[903,230,NaN]	9	hSpCas9	negative selection	9809897
68530303	68530326	17	-	27869803	PATU8988S	viability after 35 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	0.33461415399427574	[488]	[184,311,NaN]	4	hSpCas9	negative selection	9809898
68515411	68515434	17	+	27869803	PATU8988S	viability after 31 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	0.05060874525862635	[451]	[121,268,NaN]	0	hSpCas9	negative selection	9892342
68522843	68522866	17	-	27869803	PATU8988S	viability after 31 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	0.37410151809872205	[1049]	[462,643,NaN]	4	hSpCas9	negative selection	9892343
68522878	68522901	17	+	27869803	PATU8988S	viability after 31 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	0.27554205862604597	[1422]	[604,790,NaN]	3	hSpCas9	negative selection	9892344
68528864	68528887	17	+	27869803	PATU8988S	viability after 31 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	0.25262315233811294	[660]	[357,257,NaN]	3	hSpCas9	negative selection	9892345
68528917	68528940	17	-	27869803	PATU8988S	viability after 31 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	1.5760716395219347	[407]	[598,339,NaN]	9	hSpCas9	negative selection	9892346
68530303	68530326	17	-	27869803	PATU8988S	viability after 31 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	0.21483606144488476	[488]	[103,381,NaN]	2	hSpCas9	negative selection	9892347
68515411	68515434	17	+	27869803	HPAFII	viability after 35 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	0.017963226143916218	[253]	[53,215,NaN]	0	hSpCas9	negative selection	9974791
68522843	68522866	17	-	27869803	HPAFII	viability after 35 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	0.6045418413759525	[396]	[425,169,NaN]	4	hSpCas9	negative selection	9974792
68522878	68522901	17	+	27869803	HPAFII	viability after 35 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-0.06826650138038337	[546]	[27,529,NaN]	0	hSpCas9	negative selection	9974793
68528864	68528887	17	+	27869803	HPAFII	viability after 35 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	-0.003391243945449207	[303]	[169,134,NaN]	0	hSpCas9	negative selection	9974794
68528917	68528940	17	-	27869803	HPAFII	viability after 35 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	0.24300716712151701	[186]	[64,164,NaN]	1	hSpCas9	negative selection	9974795
68530303	68530326	17	-	27869803	HPAFII	viability after 35 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	-0.8046759649687889	[233]	[56,79,NaN]	-5	hSpCas9	negative selection	9974796
68515411	68515434	17	+	27869803	HPAFII	viability after 31 days	CAGTACCGCCGCCAGTGAGGAGG	PRKAR1A	ENSG00000108946	-0.17827894076245931	[253]	[91,162,NaN]	-1	hSpCas9	negative selection	10057240
68522843	68522866	17	-	27869803	HPAFII	viability after 31 days	CGCCTCCTACCTTTAACCACTGG	PRKAR1A	ENSG00000108946	0.6162686408921632	[396]	[386,291,NaN]	4	hSpCas9	negative selection	10057241
68522878	68522901	17	+	27869803	HPAFII	viability after 31 days	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-0.1871580336684705	[546]	[26,533,NaN]	-1	hSpCas9	negative selection	10057242
68528864	68528887	17	+	27869803	HPAFII	viability after 31 days	TTTCAGAGTCTCTGGACAAGTGG	PRKAR1A	ENSG00000108946	0.44240270660438935	[303]	[283,174,NaN]	3	hSpCas9	negative selection	10057243
68528917	68528940	17	-	27869803	HPAFII	viability after 31 days	TGCCCATCTTCAAACTGCACTGG	PRKAR1A	ENSG00000108946	0.2822842621459106	[186]	[29,233,NaN]	2	hSpCas9	negative selection	10057244
68530303	68530326	17	-	27869803	HPAFII	viability after 31 days	GCAACAACTGTGGCAGCACGAGG	PRKAR1A	ENSG00000108946	-0.9287677886804578	[233]	[23,117,NaN]	-5	hSpCas9	negative selection	10057245
68515416	68515439	17	-	28162770	P31FUJ	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.5674210212379247	[313]	[248]	-5	hSpCas9	negative selection	10217010
68522866	68522889	17	+	28162770	P31FUJ	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	-3.8177647051355343	[11]	[0]	-9	hSpCas9	negative selection	10217011
68515536	68515559	17	-	28162770	P31FUJ	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-1.0881224517751875	[236]	[130]	-6	hSpCas9	negative selection	10217012
68522794	68522817	17	+	28162770	P31FUJ	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-2.0703717395189907	[192]	[53]	-8	hSpCas9	negative selection	10217013
68522878	68522901	17	+	28162770	P31FUJ	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-4.6289312411431585	[378]	[17]	-9	hSpCas9	negative selection	10217014
68524934	68524957	17	+	28162770	P31FUJ	viability	TGTGATTGATCAAGGAGAGACGG	PRKAR1A	ENSG00000108946	-0.35565895219991184	[48]	[44]	-3	hSpCas9	negative selection	10217015
68528962	68528985	17	-	28162770	P31FUJ	viability	ATAATGAAGAACTCATCCCCTGG	PRKAR1A	ENSG00000108946	-1.3935086758273123	[350]	[156]	-7	hSpCas9	negative selection	10217016
68522849	68522872	17	+	28162770	P31FUJ	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-1.4212472938274887	[195]	[85]	-7	hSpCas9	negative selection	10217017
68524056	68524079	17	+	28162770	P31FUJ	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	-1.0472465512583025	[50]	[28]	-6	hSpCas9	negative selection	10217018
68525766	68525789	17	+	28162770	P31FUJ	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	0.43874798130286813	[193]	[308]	5	hSpCas9	negative selection	10217019
68515416	68515439	17	-	28162770	TF1	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	NaN	[NaN]	[218]	1	hSpCas9	negative selection	10386376
68522866	68522889	17	+	28162770	TF1	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	NaN	[NaN]	[6]	1	hSpCas9	negative selection	10386377
68515536	68515559	17	-	28162770	TF1	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	NaN	[NaN]	[280]	1	hSpCas9	negative selection	10386378
68522794	68522817	17	+	28162770	TF1	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	NaN	[NaN]	[135]	1	hSpCas9	negative selection	10386379
68522878	68522901	17	+	28162770	TF1	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	NaN	[NaN]	[364]	1	hSpCas9	negative selection	10386380
68524934	68524957	17	+	28162770	TF1	viability	TGTGATTGATCAAGGAGAGACGG	PRKAR1A	ENSG00000108946	NaN	[NaN]	[158]	1	hSpCas9	negative selection	10386381
68528962	68528985	17	-	28162770	TF1	viability	ATAATGAAGAACTCATCCCCTGG	PRKAR1A	ENSG00000108946	NaN	[NaN]	[182]	1	hSpCas9	negative selection	10386382
68522849	68522872	17	+	28162770	TF1	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	NaN	[NaN]	[207]	1	hSpCas9	negative selection	10386383
68524056	68524079	17	+	28162770	TF1	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	NaN	[NaN]	[79]	1	hSpCas9	negative selection	10386384
68525766	68525789	17	+	28162770	TF1	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	NaN	[NaN]	[456]	1	hSpCas9	negative selection	10386385
68515416	68515439	17	-	28162770	SKM1	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.12286817738153799	[84]	[137]	-1	hSpCas9	negative selection	10555742
68522866	68522889	17	+	28162770	SKM1	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	-0.8220016980220048	[1]	[1]	-6	hSpCas9	negative selection	10555743
68515536	68515559	17	-	28162770	SKM1	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-0.3641511152041885	[82]	[113]	-3	hSpCas9	negative selection	10555744
68522794	68522817	17	+	28162770	SKM1	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-1.3966958632893347	[69]	[46]	-7	hSpCas9	negative selection	10555745
68522878	68522901	17	+	28162770	SKM1	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-2.254961105298112	[107]	[39]	-8	hSpCas9	negative selection	10555746
68524934	68524957	17	+	28162770	SKM1	viability	TGTGATTGATCAAGGAGAGACGG	PRKAR1A	ENSG00000108946	-3.6293566200796095	[13]	[1]	-9	hSpCas9	negative selection	10555747
68528962	68528985	17	-	28162770	SKM1	viability	ATAATGAAGAACTCATCCCCTGG	PRKAR1A	ENSG00000108946	0.15563048894953996	[64]	[127]	1	hSpCas9	negative selection	10555748
68522849	68522872	17	+	28162770	SKM1	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-2.0443941193584534	[69]	[29]	-8	hSpCas9	negative selection	10555749
68524056	68524079	17	+	28162770	SKM1	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	-1.6155508205545792	[25]	[14]	-8	hSpCas9	negative selection	10555750
68525766	68525789	17	+	28162770	SKM1	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	-0.1968501071851505	[58]	[90]	-2	hSpCas9	negative selection	10555751
68515416	68515439	17	-	28162770	SKM1	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.12286817738153799	[84]	[137]	-1	hSpCas9	negative selection	10725108
68522866	68522889	17	+	28162770	SKM1	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	-0.8220016980220048	[1]	[1]	-6	hSpCas9	negative selection	10725109
68515536	68515559	17	-	28162770	SKM1	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-0.3641511152041885	[82]	[113]	-3	hSpCas9	negative selection	10725110
68522794	68522817	17	+	28162770	SKM1	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-1.3966958632893347	[69]	[46]	-7	hSpCas9	negative selection	10725111
68522878	68522901	17	+	28162770	SKM1	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-2.254961105298112	[107]	[39]	-8	hSpCas9	negative selection	10725112
68524934	68524957	17	+	28162770	SKM1	viability	TGTGATTGATCAAGGAGAGACGG	PRKAR1A	ENSG00000108946	-3.6293566200796095	[13]	[1]	-9	hSpCas9	negative selection	10725113
68528962	68528985	17	-	28162770	SKM1	viability	ATAATGAAGAACTCATCCCCTGG	PRKAR1A	ENSG00000108946	0.15563048894953996	[64]	[127]	1	hSpCas9	negative selection	10725114
68522849	68522872	17	+	28162770	SKM1	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-2.0443941193584534	[69]	[29]	-8	hSpCas9	negative selection	10725115
68524056	68524079	17	+	28162770	SKM1	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	-1.6155508205545792	[25]	[14]	-8	hSpCas9	negative selection	10725116
68525766	68525789	17	+	28162770	SKM1	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	-0.1968501071851505	[58]	[90]	-2	hSpCas9	negative selection	10725117
68515416	68515439	17	-	28162770	PL21	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.8506256879300582	[329]	[258]	7	hSpCas9	negative selection	10894474
68522866	68522889	17	+	28162770	PL21	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	1.20013961448932	[15]	[15]	8	hSpCas9	negative selection	10894475
68515536	68515559	17	-	28162770	PL21	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-0.24299019181887663	[241]	[88]	-2	hSpCas9	negative selection	10894476
68522794	68522817	17	+	28162770	PL21	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-1.3482970102067222	[233]	[39]	-7	hSpCas9	negative selection	10894477
68522878	68522901	17	+	28162770	PL21	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-3.0986519816001072	[432]	[21]	-9	hSpCas9	negative selection	10894478
68524934	68524957	17	+	28162770	PL21	viability	TGTGATTGATCAAGGAGAGACGG	PRKAR1A	ENSG00000108946	-1.289245226249605	[72]	[12]	-7	hSpCas9	negative selection	10894479
68528962	68528985	17	-	28162770	PL21	viability	ATAATGAAGAACTCATCCCCTGG	PRKAR1A	ENSG00000108946	-0.7606897882300021	[326]	[83]	-5	hSpCas9	negative selection	10894480
68522849	68522872	17	+	28162770	PL21	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-0.6960245745261402	[133]	[35]	-5	hSpCas9	negative selection	10894481
68524056	68524079	17	+	28162770	PL21	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	-0.6072153075682838	[76]	[21]	-4	hSpCas9	negative selection	10894482
68525766	68525789	17	+	28162770	PL21	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	0.4452521123258515	[188]	[111]	4	hSpCas9	negative selection	10894483
68515416	68515439	17	-	28162770	P31FUJ	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.5674210212379247	[313]	[248]	-5	hSpCas9	negative selection	11063840
68522866	68522889	17	+	28162770	P31FUJ	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	-3.8177647051355343	[11]	[0]	-9	hSpCas9	negative selection	11063841
68515536	68515559	17	-	28162770	P31FUJ	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-1.0881224517751875	[236]	[130]	-6	hSpCas9	negative selection	11063842
68522794	68522817	17	+	28162770	P31FUJ	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-2.0703717395189907	[192]	[53]	-8	hSpCas9	negative selection	11063843
68522878	68522901	17	+	28162770	P31FUJ	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-4.6289312411431585	[378]	[17]	-9	hSpCas9	negative selection	11063844
68524934	68524957	17	+	28162770	P31FUJ	viability	TGTGATTGATCAAGGAGAGACGG	PRKAR1A	ENSG00000108946	-0.35565895219991184	[48]	[44]	-3	hSpCas9	negative selection	11063845
68528962	68528985	17	-	28162770	P31FUJ	viability	ATAATGAAGAACTCATCCCCTGG	PRKAR1A	ENSG00000108946	-1.3935086758273123	[350]	[156]	-7	hSpCas9	negative selection	11063846
68522849	68522872	17	+	28162770	P31FUJ	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-1.4212472938274887	[195]	[85]	-7	hSpCas9	negative selection	11063847
68524056	68524079	17	+	28162770	P31FUJ	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	-1.0472465512583025	[50]	[28]	-6	hSpCas9	negative selection	11063848
68525766	68525789	17	+	28162770	P31FUJ	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	0.43874798130286813	[193]	[308]	5	hSpCas9	negative selection	11063849
68515416	68515439	17	-	28162770	OCIAML5	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.6968266751496373	[134]	[394]	6	hSpCas9	negative selection	11233206
68522866	68522889	17	+	28162770	OCIAML5	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	-5.021991572306309	[17]	[0]	-9	hSpCas9	negative selection	11233207
68515536	68515559	17	-	28162770	OCIAML5	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-0.7864782292364201	[128]	[134]	-5	hSpCas9	negative selection	11233208
68522794	68522817	17	+	28162770	OCIAML5	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.6762167354645792	[53]	[60]	-4	hSpCas9	negative selection	11233209
68522878	68522901	17	+	28162770	OCIAML5	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-1.7472242050064988	[198]	[106]	-7	hSpCas9	negative selection	11233210
68524934	68524957	17	+	28162770	OCIAML5	viability	TGTGATTGATCAAGGAGAGACGG	PRKAR1A	ENSG00000108946	-2.0891057681648464	[32]	[13]	-8	hSpCas9	negative selection	11233211
68528962	68528985	17	-	28162770	OCIAML5	viability	ATAATGAAGAACTCATCCCCTGG	PRKAR1A	ENSG00000108946	-0.5114790207450343	[168]	[213]	-4	hSpCas9	negative selection	11233212
68522849	68522872	17	+	28162770	OCIAML5	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-0.999408286939184	[102]	[92]	-6	hSpCas9	negative selection	11233213
68524056	68524079	17	+	28162770	OCIAML5	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	-2.8293464943639135	[62]	[15]	-8	hSpCas9	negative selection	11233214
68525766	68525789	17	+	28162770	OCIAML5	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	0.2564578859141722	[127]	[275]	2	hSpCas9	negative selection	11233215
68515416	68515439	17	-	28162770	EOL1	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.7537070639464871	[590]	[524]	6	hSpCas9	negative selection	11402572
68522866	68522889	17	+	28162770	EOL1	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	2.365120362956516	[6]	[18]	9	hSpCas9	negative selection	11402573
68515536	68515559	17	-	28162770	EOL1	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	0.5248645191687269	[404]	[306]	5	hSpCas9	negative selection	11402574
68522794	68522817	17	+	28162770	EOL1	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-1.064699172132591	[400]	[100]	-6	hSpCas9	negative selection	11402575
68522878	68522901	17	+	28162770	EOL1	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-0.5629385777780014	[700]	[249]	-4	hSpCas9	negative selection	11402576
68524934	68524957	17	+	28162770	EOL1	viability	TGTGATTGATCAAGGAGAGACGG	PRKAR1A	ENSG00000108946	-0.005743256618061077	[100]	[52]	0	hSpCas9	negative selection	11402577
68528962	68528985	17	-	28162770	EOL1	viability	ATAATGAAGAACTCATCCCCTGG	PRKAR1A	ENSG00000108946	-1.185299409276535	[340]	[78]	-7	hSpCas9	negative selection	11402578
68522849	68522872	17	+	28162770	EOL1	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-0.5205917594977285	[225]	[82]	-4	hSpCas9	negative selection	11402579
68524056	68524079	17	+	28162770	EOL1	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	-0.16291506967980496	[101]	[47]	-1	hSpCas9	negative selection	11402580
68525766	68525789	17	+	28162770	EOL1	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	0.6350411543755495	[241]	[197]	5	hSpCas9	negative selection	11402581
68515416	68515439	17	-	28162770	MOLM13	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.5038686786501453	[395]	[405]	4	hSpCas9	negative selection	11571938
68522866	68522889	17	+	28162770	MOLM13	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	-1.1170731191765775	[11]	[3]	-5	hSpCas9	negative selection	11571939
68515536	68515559	17	-	28162770	MOLM13	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-0.07550662645093345	[324]	[222]	0	hSpCas9	negative selection	11571940
68522794	68522817	17	+	28162770	MOLM13	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-2.368034692709796	[356]	[49]	-8	hSpCas9	negative selection	11571941
68522878	68522901	17	+	28162770	MOLM13	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-5.225597575954746	[620]	[11]	-9	hSpCas9	negative selection	11571942
68524934	68524957	17	+	28162770	MOLM13	viability	TGTGATTGATCAAGGAGAGACGG	PRKAR1A	ENSG00000108946	-6.246356136121545	[104]	[0]	-9	hSpCas9	negative selection	11571943
68528962	68528985	17	-	28162770	MOLM13	viability	ATAATGAAGAACTCATCCCCTGG	PRKAR1A	ENSG00000108946	-2.4151080077529476	[508]	[68]	-8	hSpCas9	negative selection	11571944
68522849	68522872	17	+	28162770	MOLM13	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-0.6278696012608519	[217]	[101]	-4	hSpCas9	negative selection	11571945
68524056	68524079	17	+	28162770	MOLM13	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	-0.9342090620267668	[147]	[55]	-5	hSpCas9	negative selection	11571946
68525766	68525789	17	+	28162770	MOLM13	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	0.6487855008078943	[261]	[296]	5	hSpCas9	negative selection	11571947
68515416	68515439	17	-	28162770	HEL	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.4869441593929328	[380]	[341]	4	hSpCas9	negative selection	11741304
68522866	68522889	17	+	28162770	HEL	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	1.280168752615649	[8]	[13]	9	hSpCas9	negative selection	11741305
68515536	68515559	17	-	28162770	HEL	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-1.030579543141646	[302]	[94]	-6	hSpCas9	negative selection	11741306
68522794	68522817	17	+	28162770	HEL	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-1.2376795522469708	[242]	[65]	-6	hSpCas9	negative selection	11741307
68522878	68522901	17	+	28162770	HEL	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-2.6412926551284768	[525]	[53]	-8	hSpCas9	negative selection	11741308
68524934	68524957	17	+	28162770	HEL	viability	TGTGATTGATCAAGGAGAGACGG	PRKAR1A	ENSG00000108946	-2.661041916176746	[78]	[7]	-8	hSpCas9	negative selection	11741309
68528962	68528985	17	-	28162770	HEL	viability	ATAATGAAGAACTCATCCCCTGG	PRKAR1A	ENSG00000108946	-2.1221808237368505	[468]	[68]	-8	hSpCas9	negative selection	11741310
68522849	68522872	17	+	28162770	HEL	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	0.40725075305222563	[165]	[140]	3	hSpCas9	negative selection	11741311
68524056	68524079	17	+	28162770	HEL	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	0.494640193011223	[81]	[73]	4	hSpCas9	negative selection	11741312
68525766	68525789	17	+	28162770	HEL	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	0.7320061700974443	[187]	[199]	6	hSpCas9	negative selection	11741313
68515416	68515439	17	-	28162770	MV411	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.493893235944833	[330]	[197]	-4	hSpCas9	negative selection	11910670
68522866	68522889	17	+	28162770	MV411	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	-0.16759994849606885	[11]	[8]	-1	hSpCas9	negative selection	11910671
68515536	68515559	17	-	28162770	MV411	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-1.287985489137066	[228]	[78]	-7	hSpCas9	negative selection	11910672
68522794	68522817	17	+	28162770	MV411	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-1.4928031754162918	[293]	[87]	-7	hSpCas9	negative selection	11910673
68522878	68522901	17	+	28162770	MV411	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-2.653998614733635	[395]	[52]	-9	hSpCas9	negative selection	11910674
68524934	68524957	17	+	28162770	MV411	viability	TGTGATTGATCAAGGAGAGACGG	PRKAR1A	ENSG00000108946	-1.8477196822575648	[46]	[10]	-8	hSpCas9	negative selection	11910675
68528962	68528985	17	-	28162770	MV411	viability	ATAATGAAGAACTCATCCCCTGG	PRKAR1A	ENSG00000108946	-1.1818740794781866	[236]	[87]	-6	hSpCas9	negative selection	11910676
68522849	68522872	17	+	28162770	MV411	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	0.305384899992055	[121]	[126]	2	hSpCas9	negative selection	11910677
68524056	68524079	17	+	28162770	MV411	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	1.2701576272828587	[62]	[127]	9	hSpCas9	negative selection	11910678
68525766	68525789	17	+	28162770	MV411	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	0.18888536842766235	[175]	[168]	1	hSpCas9	negative selection	11910679
68515416	68515439	17	-	28162770	MONOMAC1	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	0.5527670524358919	[178]	[300]	5	hSpCas9	negative selection	12080036
68522866	68522889	17	+	28162770	MONOMAC1	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	-1.6564684656968511	[10]	[3]	-8	hSpCas9	negative selection	12080037
68515536	68515559	17	-	28162770	MONOMAC1	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-0.598399409441321	[139]	[105]	-5	hSpCas9	negative selection	12080038
68522794	68522817	17	+	28162770	MONOMAC1	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.9132438810589624	[114]	[69]	-6	hSpCas9	negative selection	12080039
68522878	68522901	17	+	28162770	MONOMAC1	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-1.3402938980397858	[200]	[90]	-7	hSpCas9	negative selection	12080040
68524934	68524957	17	+	28162770	MONOMAC1	viability	TGTGATTGATCAAGGAGAGACGG	PRKAR1A	ENSG00000108946	-1.7516256987371912	[46]	[15]	-8	hSpCas9	negative selection	12080041
68528962	68528985	17	-	28162770	MONOMAC1	viability	ATAATGAAGAACTCATCCCCTGG	PRKAR1A	ENSG00000108946	-1.7242838499244222	[146]	[50]	-8	hSpCas9	negative selection	12080042
68522849	68522872	17	+	28162770	MONOMAC1	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-0.9537656960471899	[97]	[57]	-6	hSpCas9	negative selection	12080043
68524056	68524079	17	+	28162770	MONOMAC1	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	-2.305561303837723	[68]	[15]	-9	hSpCas9	negative selection	12080044
68525766	68525789	17	+	28162770	MONOMAC1	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	-2.1845459028763567	[114]	[28]	-9	hSpCas9	negative selection	12080045
68515416	68515439	17	-	28162770	OCIAML2	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.6377398110774195	[63]	[227]	-5	hSpCas9	negative selection	12249402
68522866	68522889	17	+	28162770	OCIAML2	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	-2.4706298252421615	[3]	[3]	-8	hSpCas9	negative selection	12249403
68515536	68515559	17	-	28162770	OCIAML2	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-0.5987861767328435	[49]	[182]	-4	hSpCas9	negative selection	12249404
68522794	68522817	17	+	28162770	OCIAML2	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.5071557012672752	[39]	[155]	-4	hSpCas9	negative selection	12249405
68522878	68522901	17	+	28162770	OCIAML2	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-2.818553128662468	[69]	[54]	-9	hSpCas9	negative selection	12249406
68524934	68524957	17	+	28162770	OCIAML2	viability	TGTGATTGATCAAGGAGAGACGG	PRKAR1A	ENSG00000108946	-0.842598602629119	[10]	[33]	-5	hSpCas9	negative selection	12249407
68528962	68528985	17	-	28162770	OCIAML2	viability	ATAATGAAGAACTCATCCCCTGG	PRKAR1A	ENSG00000108946	-1.50100347428568	[47]	[93]	-7	hSpCas9	negative selection	12249408
68522849	68522872	17	+	28162770	OCIAML2	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-0.266271326735975	[22]	[105]	-2	hSpCas9	negative selection	12249409
68524056	68524079	17	+	28162770	OCIAML2	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	-2.0345307104354875	[16]	[22]	-8	hSpCas9	negative selection	12249410
68525766	68525789	17	+	28162770	OCIAML2	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	-0.543142325026529	[50]	[193]	-4	hSpCas9	negative selection	12249411
68515416	68515439	17	-	28162770	OCIAML3	viability	GCGTGCCTCCTCACTGGCGGCGG	PRKAR1A	ENSG00000108946	-0.5051983733663071	[62]	[133]	-4	hSpCas9	negative selection	12418768
68522866	68522889	17	+	28162770	OCIAML3	viability	ACGAGGTGCTATCAGCGCTGAGG	PRKAR1A	ENSG00000108946	0.8654239783131343	[3]	[21]	7	hSpCas9	negative selection	12418769
68515536	68515559	17	-	28162770	OCIAML3	viability	GTATTCCCTGAGGAATGCCATGG	PRKAR1A	ENSG00000108946	-0.1322769055972779	[56]	[156]	-1	hSpCas9	negative selection	12418770
68522794	68522817	17	+	28162770	OCIAML3	viability	CACTCGTACAGACTCAAGGGAGG	PRKAR1A	ENSG00000108946	-0.4030648576127679	[52]	[120]	-3	hSpCas9	negative selection	12418771
68522878	68522901	17	+	28162770	OCIAML3	viability	CAGCGCTGAGGTCTACACGGAGG	PRKAR1A	ENSG00000108946	-1.1825813945976982	[99]	[132]	-7	hSpCas9	negative selection	12418772
68524934	68524957	17	+	28162770	OCIAML3	viability	TGTGATTGATCAAGGAGAGACGG	PRKAR1A	ENSG00000108946	0.33887816381729985	[21]	[83]	3	hSpCas9	negative selection	12418773
68528962	68528985	17	-	28162770	OCIAML3	viability	ATAATGAAGAACTCATCCCCTGG	PRKAR1A	ENSG00000108946	0.31745568507417943	[62]	[236]	3	hSpCas9	negative selection	12418774
68522849	68522872	17	+	28162770	OCIAML3	viability	GTTAAAGGTAGGAGGCGACGAGG	PRKAR1A	ENSG00000108946	-0.4387294148462522	[65]	[146]	-3	hSpCas9	negative selection	12418775
68524056	68524079	17	+	28162770	OCIAML3	viability	GGAGAGACTGTGATTCAGCAAGG	PRKAR1A	ENSG00000108946	-1.639811329937288	[31]	[30]	-8	hSpCas9	negative selection	12418776
68525766	68525789	17	+	28162770	OCIAML3	viability	AATGAATGGGCAACCAGTGTTGG	PRKAR1A	ENSG00000108946	-0.002731365670804675	[75]	[228]	0	hSpCas9	negative selection	12418777