Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:5576
• Symbol:PRKAR2A
• Description:protein kinase cAMP-dependent type II regulatory subunit alpha

DataSource: http://genomecrispr.dkfz.de/#!/results/PRKAR2A

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
48847334	48847357	3	-	26472758	Jiyoye	viability	GAGGAGGACGAGGACTTGGAAGG	PRKAR2A	ENSG00000114302	-1.680287459744466	[16]	[3]	-8	hSpCas9	negative selection	127373
48847539	48847562	3	-	26472758	Jiyoye	viability	GCTGCTGCAGGGCTACACGGTGG	PRKAR2A	ENSG00000114302	-0.30064386700081613	[146]	[89]	-2	hSpCas9	negative selection	127374
48847494	48847517	3	-	26472758	Jiyoye	viability	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	-0.045336823191633346	[25]	[18]	0	hSpCas9	negative selection	127375
48765023	48765046	3	-	26472758	Jiyoye	viability	GGAGAGAAGATCTATAAGGATGG	PRKAR2A	ENSG00000114302	0.23208867494778218	[69]	[61]	1	hSpCas9	negative selection	127376
48847441	48847464	3	+	26472758	Jiyoye	viability	GGCGGGCAGGACTGAGGCTGGGG	PRKAR2A	ENSG00000114302	-0.6389210330835805	[158]	[76]	-4	hSpCas9	negative selection	127377
48847353	48847376	3	-	26472758	Jiyoye	viability	CAAAGGGGACAGCGAGTCGGAGG	PRKAR2A	ENSG00000114302	1.0212842278865462	[48]	[74]	6	hSpCas9	negative selection	127378
48793996	48794019	3	-	26472758	Jiyoye	viability	AGAGGAAGATACAGATCCAAGGG	PRKAR2A	ENSG00000114302	-0.04968229346759734	[69]	[50]	0	hSpCas9	negative selection	127379
48773040	48773063	3	-	26472758	Jiyoye	viability	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	0.9294021268790671	[93]	[134]	6	hSpCas9	negative selection	127380
48752284	48752307	3	-	26472758	Jiyoye	viability	CAAGGATGGTGGGAACCAGGAGG	PRKAR2A	ENSG00000114302	2.300260177589361	[6]	[25]	9	hSpCas9	negative selection	127381
48847334	48847357	3	-	26472758	KBM7	viability	GAGGAGGACGAGGACTTGGAAGG	PRKAR2A	ENSG00000114302	-1.9057673988623183	[138,150]	[20,15]	-8	hSpCas9	negative selection	318491
48847539	48847562	3	-	26472758	KBM7	viability	GCTGCTGCAGGGCTACACGGTGG	PRKAR2A	ENSG00000114302	0.13889048411653	[361,285]	[212,124]	1	hSpCas9	negative selection	318492
48847494	48847517	3	-	26472758	KBM7	viability	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	0.7221745345774453	[166,153]	[207,49]	7	hSpCas9	negative selection	318493
48765023	48765046	3	-	26472758	KBM7	viability	GGAGAGAAGATCTATAAGGATGG	PRKAR2A	ENSG00000114302	-0.426168479034009	[348,145]	[141,30]	-4	hSpCas9	negative selection	318494
48847441	48847464	3	+	26472758	KBM7	viability	GGCGGGCAGGACTGAGGCTGGGG	PRKAR2A	ENSG00000114302	0.03396824935471998	[371,376]	[175,185]	0	hSpCas9	negative selection	318495
48847353	48847376	3	-	26472758	KBM7	viability	CAAAGGGGACAGCGAGTCGGAGG	PRKAR2A	ENSG00000114302	-0.1873289862374471	[344,434]	[149,175]	-2	hSpCas9	negative selection	318496
48793996	48794019	3	-	26472758	KBM7	viability	AGAGGAAGATACAGATCCAAGGG	PRKAR2A	ENSG00000114302	-0.5347075173446432	[188,83]	[46,38]	-5	hSpCas9	negative selection	318497
48773040	48773063	3	-	26472758	KBM7	viability	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	-0.15823466639121225	[364,350]	[164,138]	-1	hSpCas9	negative selection	318498
48752284	48752307	3	-	26472758	KBM7	viability	CAAGGATGGTGGGAACCAGGAGG	PRKAR2A	ENSG00000114302	-0.1041075997375831	[85,39]	[32,20]	-1	hSpCas9	negative selection	318499
48847334	48847357	3	-	26472758	Raji	viability	GAGGAGGACGAGGACTTGGAAGG	PRKAR2A	ENSG00000114302	-3.352048083263698	[87]	[1]	-9	hSpCas9	negative selection	509609
48847539	48847562	3	-	26472758	Raji	viability	GCTGCTGCAGGGCTACACGGTGG	PRKAR2A	ENSG00000114302	0.45909509928361397	[162]	[51]	4	hSpCas9	negative selection	509610
48847494	48847517	3	-	26472758	Raji	viability	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	1.3911765013741906	[22]	[13]	9	hSpCas9	negative selection	509611
48765023	48765046	3	-	26472758	Raji	viability	GGAGAGAAGATCTATAAGGATGG	PRKAR2A	ENSG00000114302	-0.4884672814902927	[132]	[21]	-4	hSpCas9	negative selection	509612
48847441	48847464	3	+	26472758	Raji	viability	GGCGGGCAGGACTGAGGCTGGGG	PRKAR2A	ENSG00000114302	-1.1296556619272498	[197]	[20]	-7	hSpCas9	negative selection	509613
48847353	48847376	3	-	26472758	Raji	viability	CAAAGGGGACAGCGAGTCGGAGG	PRKAR2A	ENSG00000114302	-0.65416769707088	[216]	[31]	-5	hSpCas9	negative selection	509614
48793996	48794019	3	-	26472758	Raji	viability	AGAGGAAGATACAGATCCAAGGG	PRKAR2A	ENSG00000114302	0.5983698878857417	[73]	[25]	5	hSpCas9	negative selection	509615
48773040	48773063	3	-	26472758	Raji	viability	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	-0.7505974597539727	[347]	[47]	-5	hSpCas9	negative selection	509616
48752284	48752307	3	-	26472758	Raji	viability	CAAGGATGGTGGGAACCAGGAGG	PRKAR2A	ENSG00000114302	-1.5555814773488303	[37]	[2]	-8	hSpCas9	negative selection	509617
48847334	48847357	3	-	26472758	K562	viability	GAGGAGGACGAGGACTTGGAAGG	PRKAR2A	ENSG00000114302	-3.4760587437111905	[144]	[10]	-8	hSpCas9	negative selection	700727
48847539	48847562	3	-	26472758	K562	viability	GCTGCTGCAGGGCTACACGGTGG	PRKAR2A	ENSG00000114302	0.255645983089701	[255]	[257]	2	hSpCas9	negative selection	700728
48847494	48847517	3	-	26472758	K562	viability	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	0.16498426017204193	[111]	[105]	1	hSpCas9	negative selection	700729
48765023	48765046	3	-	26472758	K562	viability	GGAGAGAAGATCTATAAGGATGG	PRKAR2A	ENSG00000114302	-0.45420055485027633	[197]	[121]	-3	hSpCas9	negative selection	700730
48847441	48847464	3	+	26472758	K562	viability	GGCGGGCAGGACTGAGGCTGGGG	PRKAR2A	ENSG00000114302	-0.957557857115907	[420]	[182]	-5	hSpCas9	negative selection	700731
48847353	48847376	3	-	26472758	K562	viability	CAAAGGGGACAGCGAGTCGGAGG	PRKAR2A	ENSG00000114302	1.6612406366234735	[302]	[808]	9	hSpCas9	negative selection	700732
48793996	48794019	3	-	26472758	K562	viability	AGAGGAAGATACAGATCCAAGGG	PRKAR2A	ENSG00000114302	0.4585435330192944	[124]	[144]	3	hSpCas9	negative selection	700733
48773040	48773063	3	-	26472758	K562	viability	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	-0.2714594611192245	[315]	[220]	-2	hSpCas9	negative selection	700734
48752284	48752307	3	-	26472758	K562	viability	CAAGGATGGTGGGAACCAGGAGG	PRKAR2A	ENSG00000114302	0.357629338114438	[48]	[52]	3	hSpCas9	negative selection	700735
48751660	48751683	3	-	26627737	DLD1	viability	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	-0.03606827449714256	[1134]	[335,393,314]	0	hSpCas9	negative selection	822149
48752215	48752238	3	+	26627737	DLD1	viability	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	0.37505100678044073	[593]	[177,321,227]	4	hSpCas9	negative selection	822150
48772971	48772994	3	-	26627737	DLD1	viability	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	0.5018115021836895	[365]	[118,142,214]	5	hSpCas9	negative selection	822151
48794014	48794037	3	-	26627737	DLD1	viability	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	0.44765856497586326	[642]	[283,211,316]	4	hSpCas9	negative selection	822152
48847368	48847391	3	-	26627737	DLD1	viability	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	0.11550285875794719	[992]	[350,447,230]	1	hSpCas9	negative selection	822153
48847369	48847392	3	-	26627737	DLD1	viability	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	0.8397450056554321	[561]	[378,355,223]	7	hSpCas9	negative selection	822154
48751660	48751683	3	-	26627737	GBM cells	viability after 5 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	-0.14594036089857498	[587]	[318,250]	-2	hSpCas9	negative selection	904464
48752215	48752238	3	+	26627737	GBM cells	viability after 5 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	-0.5199152035555324	[380]	[135,148]	-7	hSpCas9	negative selection	904465
48772971	48772994	3	-	26627737	GBM cells	viability after 5 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	-0.22210152607568046	[173]	[81,77]	-3	hSpCas9	negative selection	904466
48794014	48794037	3	-	26627737	GBM cells	viability after 5 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	-0.043309793835113575	[464]	[240,242]	0	hSpCas9	negative selection	904467
48847368	48847391	3	-	26627737	GBM cells	viability after 5 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	0.12741510580477922	[605]	[330,378]	2	hSpCas9	negative selection	904468
48847369	48847392	3	-	26627737	GBM cells	viability after 5 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	0.2966069113430354	[522]	[404,283]	4	hSpCas9	negative selection	904469
48751660	48751683	3	-	26627737	GBM cells	viability after 13 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	-0.37384780036741383	[587]	[243,247]	-4	hSpCas9	negative selection	986779
48752215	48752238	3	+	26627737	GBM cells	viability after 13 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	-0.29449865944870685	[380]	[167,168]	-4	hSpCas9	negative selection	986780
48772971	48772994	3	-	26627737	GBM cells	viability after 13 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	-0.6200517853578275	[173]	[88,38]	-6	hSpCas9	negative selection	986781
48794014	48794037	3	-	26627737	GBM cells	viability after 13 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	0.09243914446400525	[464]	[252,281]	1	hSpCas9	negative selection	986782
48847368	48847391	3	-	26627737	GBM cells	viability after 13 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	0.0856475734333817	[605]	[381,321]	1	hSpCas9	negative selection	986783
48847369	48847392	3	-	26627737	GBM cells	viability after 13 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	0.4841105024353807	[522]	[504,308]	6	hSpCas9	negative selection	986784
48751660	48751683	3	-	26627737	GBM cells	viability after 21 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	-0.3123806223076697	[587]	[262,251]	-3	hSpCas9	negative selection	1069094
48752215	48752238	3	+	26627737	GBM cells	viability after 21 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	-0.7945606113345633	[380]	[134,104]	-6	hSpCas9	negative selection	1069095
48772971	48772994	3	-	26627737	GBM cells	viability after 21 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	-0.09275188447558136	[173]	[96,80]	-1	hSpCas9	negative selection	1069096
48794014	48794037	3	-	26627737	GBM cells	viability after 21 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	0.12307525738204284	[464]	[283,266]	1	hSpCas9	negative selection	1069097
48847368	48847391	3	-	26627737	GBM cells	viability after 21 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	0.02694156824002203	[605]	[336,333]	0	hSpCas9	negative selection	1069098
48847369	48847392	3	-	26627737	GBM cells	viability after 21 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	0.4891279577682037	[522]	[461,340]	5	hSpCas9	negative selection	1069099
48751660	48751683	3	-	26627737	RPE1	viability after 9 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	0.9247680972807829	[867]	[421,636]	6	hSpCas9	negative selection	1151409
48752215	48752238	3	+	26627737	RPE1	viability after 9 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	-0.25630454430386196	[1073]	[315,236]	-2	hSpCas9	negative selection	1151410
48772971	48772994	3	-	26627737	RPE1	viability after 9 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	-1.1108186682687582	[680]	[51,158]	-7	hSpCas9	negative selection	1151411
48794014	48794037	3	-	26627737	RPE1	viability after 9 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	-0.5331757404431122	[1823]	[353,446]	-4	hSpCas9	negative selection	1151412
48847368	48847391	3	-	26627737	RPE1	viability after 9 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	0.2130325313613286	[1849]	[683,654]	1	hSpCas9	negative selection	1151413
48847369	48847392	3	-	26627737	RPE1	viability after 9 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	1.8201657121006227	[951]	[748,1443]	8	hSpCas9	negative selection	1151414
48751660	48751683	3	-	26627737	RPE1	viability after 12 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	0.8596585927459451	[867]	[428,416]	5	hSpCas9	negative selection	1233724
48752215	48752238	3	+	26627737	RPE1	viability after 12 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	-0.937268027392681	[1073]	[156,143]	-6	hSpCas9	negative selection	1233725
48772971	48772994	3	-	26627737	RPE1	viability after 12 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	-1.6160858162167915	[680]	[31,88]	-8	hSpCas9	negative selection	1233726
48794014	48794037	3	-	26627737	RPE1	viability after 12 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	-0.24100346839700837	[1823]	[402,426]	-2	hSpCas9	negative selection	1233727
48847368	48847391	3	-	26627737	RPE1	viability after 12 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	0.37595720658008003	[1849]	[627,662]	2	hSpCas9	negative selection	1233728
48847369	48847392	3	-	26627737	RPE1	viability after 12 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	1.5746703389905843	[951]	[518,1018]	8	hSpCas9	negative selection	1233729
48751660	48751683	3	-	26627737	RPE1	viability after 15 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	1.2259345493931888	[867]	[611,537]	7	hSpCas9	negative selection	1316039
48752215	48752238	3	+	26627737	RPE1	viability after 15 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	0.020922385849874492	[1073]	[462,158]	0	hSpCas9	negative selection	1316040
48772971	48772994	3	-	26627737	RPE1	viability after 15 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	-0.7404171643334093	[680]	[97,131]	-5	hSpCas9	negative selection	1316041
48794014	48794037	3	-	26627737	RPE1	viability after 15 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	-0.05468285111008542	[1823]	[452,538]	0	hSpCas9	negative selection	1316042
48847368	48847391	3	-	26627737	RPE1	viability after 15 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	0.19199880903891064	[1849]	[579,614]	1	hSpCas9	negative selection	1316043
48847369	48847392	3	-	26627737	RPE1	viability after 15 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	1.2185445852754975	[951]	[418,826]	7	hSpCas9	negative selection	1316044
48751660	48751683	3	-	26627737	RPE1	viability after 18 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	0.3566393996423841	[867]	[268,332]	2	hSpCas9	negative selection	1398354
48752215	48752238	3	+	26627737	RPE1	viability after 18 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	-0.5576483500467861	[1073]	[281,105]	-4	hSpCas9	negative selection	1398355
48772971	48772994	3	-	26627737	RPE1	viability after 18 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	-0.7462753522905217	[680]	[52,169]	-5	hSpCas9	negative selection	1398356
48794014	48794037	3	-	26627737	RPE1	viability after 18 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	-0.6357025841421725	[1823]	[296,337]	-4	hSpCas9	negative selection	1398357
48847368	48847391	3	-	26627737	RPE1	viability after 18 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	0.2629991738241	[1849]	[630,564]	1	hSpCas9	negative selection	1398358
48847369	48847392	3	-	26627737	RPE1	viability after 18 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	1.1625421133941716	[951]	[519,633]	6	hSpCas9	negative selection	1398359
48751660	48751683	3	-	26627737	HeLa	viability after 8 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	-0.98699999851661	[980]	[357,170,152]	-7	hSpCas9	negative selection	1480669
48752215	48752238	3	+	26627737	HeLa	viability after 8 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	0.34571086816628094	[364]	[122,201,258]	3	hSpCas9	negative selection	1480670
48772971	48772994	3	-	26627737	HeLa	viability after 8 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	-1.1643052225207646	[274]	[58,42,58]	-8	hSpCas9	negative selection	1480671
48794014	48794037	3	-	26627737	HeLa	viability after 8 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	-0.686831086736752	[935]	[375,199,212]	-6	hSpCas9	negative selection	1480672
48847368	48847391	3	-	26627737	HeLa	viability after 8 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	-0.42495575844226097	[1159]	[567,267,336]	-4	hSpCas9	negative selection	1480673
48847369	48847392	3	-	26627737	HeLa	viability after 8 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	1.0671420351297272	[526]	[588,479,401]	7	hSpCas9	negative selection	1480674
48751660	48751683	3	-	26627737	HeLa	viability after 12 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	-0.9318298411505888	[980]	[336,147,162]	-7	hSpCas9	negative selection	1562984
48752215	48752238	3	+	26627737	HeLa	viability after 12 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	0.8493150558591608	[364]	[373,160,294]	6	hSpCas9	negative selection	1562985
48772971	48772994	3	-	26627737	HeLa	viability after 12 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	0.4700361261407391	[274]	[239,106,132]	4	hSpCas9	negative selection	1562986
48794014	48794037	3	-	26627737	HeLa	viability after 12 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	-0.06246951922972799	[935]	[540,315,264]	0	hSpCas9	negative selection	1562987
48847368	48847391	3	-	26627737	HeLa	viability after 12 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	0.021813924099718163	[1159]	[815,237,441]	0	hSpCas9	negative selection	1562988
48847369	48847392	3	-	26627737	HeLa	viability after 12 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	1.0156297560077667	[526]	[709,381,242]	7	hSpCas9	negative selection	1562989
48751660	48751683	3	-	26627737	HeLa	viability after 15 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	-0.8375037999989152	[980]	[336,168,157]	-6	hSpCas9	negative selection	1645299
48752215	48752238	3	+	26627737	HeLa	viability after 15 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	0.7984249044844762	[364]	[138,304,338]	6	hSpCas9	negative selection	1645300
48772971	48772994	3	-	26627737	HeLa	viability after 15 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	0.5782084551536815	[274]	[139,179,182]	5	hSpCas9	negative selection	1645301
48794014	48794037	3	-	26627737	HeLa	viability after 15 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	0.1978756609857717	[935]	[477,451,375]	1	hSpCas9	negative selection	1645302
48847368	48847391	3	-	26627737	HeLa	viability after 15 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	-0.45158319458936225	[1159]	[582,211,228]	-4	hSpCas9	negative selection	1645303
48847369	48847392	3	-	26627737	HeLa	viability after 15 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	0.9210020937679588	[526]	[262,629,320]	7	hSpCas9	negative selection	1645304
48751660	48751683	3	-	26627737	HeLa	viability after 18 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	-0.8470437694834541	[980]	[227,133,157]	-6	hSpCas9	negative selection	1727614
48752215	48752238	3	+	26627737	HeLa	viability after 18 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	0.7831255205463973	[364]	[85,254,338]	6	hSpCas9	negative selection	1727615
48772971	48772994	3	-	26627737	HeLa	viability after 18 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	0.5871832228588043	[274]	[91,153,182]	5	hSpCas9	negative selection	1727616
48794014	48794037	3	-	26627737	HeLa	viability after 18 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	0.2030648223260998	[935]	[327,368,375]	1	hSpCas9	negative selection	1727617
48847368	48847391	3	-	26627737	HeLa	viability after 18 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	-0.4619455758244466	[1159]	[385,175,228]	-4	hSpCas9	negative selection	1727618
48847369	48847392	3	-	26627737	HeLa	viability after 18 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	0.930121706663158	[526]	[177,525,320]	7	hSpCas9	negative selection	1727619
48751660	48751683	3	-	26627737	HCT116	viability after 6 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	0.7332852992131803	[1182]	[488,209]	4	hSpCas9	negative selection	1809929
48752215	48752238	3	+	26627737	HCT116	viability after 6 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	-0.602679949245972	[1197]	[114,128]	-3	hSpCas9	negative selection	1809930
48772971	48772994	3	-	26627737	HCT116	viability after 6 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	0.1942601995954616	[373]	[45,78]	1	hSpCas9	negative selection	1809931
48794014	48794037	3	-	26627737	HCT116	viability after 6 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	0.9778019517009077	[967]	[57,432]	5	hSpCas9	negative selection	1809932
48847368	48847391	3	-	26627737	HCT116	viability after 6 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	-0.6525847945361613	[1481]	[231,101]	-4	hSpCas9	negative selection	1809933
48847369	48847392	3	-	26627737	HCT116	viability after 6 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	-0.02727232329313023	[1280]	[399,85]	0	hSpCas9	negative selection	1809934
48751660	48751683	3	-	26627737	HCT116	viability after 8 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	0.03394489431138692	[521]	[193,338,347]	0	hSpCas9	negative selection	1892244
48752215	48752238	3	+	26627737	HCT116	viability after 8 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	0.1657188124913056	[317]	[209,190,188]	2	hSpCas9	negative selection	1892245
48772971	48772994	3	-	26627737	HCT116	viability after 8 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	-0.22931150066319236	[271]	[142,126,113]	-3	hSpCas9	negative selection	1892246
48794014	48794037	3	-	26627737	HCT116	viability after 8 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	0.07046130175394294	[387]	[130,247,291]	0	hSpCas9	negative selection	1892247
48847368	48847391	3	-	26627737	HCT116	viability after 8 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	0.5916616671297477	[589]	[431,484,550]	6	hSpCas9	negative selection	1892248
48847369	48847392	3	-	26627737	HCT116	viability after 8 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	0.3525381977468478	[468]	[246,376,363]	4	hSpCas9	negative selection	1892249
48751660	48751683	3	-	26627737	HCT116	viability after 9 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	0.25937605459223356	[1182]	[276,457]	2	hSpCas9	negative selection	1974559
48752215	48752238	3	+	26627737	HCT116	viability after 9 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	-0.1256899540091655	[1197]	[338,256]	-1	hSpCas9	negative selection	1974560
48772971	48772994	3	-	26627737	HCT116	viability after 9 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	0.6589116567350599	[373]	[217,109]	5	hSpCas9	negative selection	1974561
48794014	48794037	3	-	26627737	HCT116	viability after 9 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	0.17082324953086114	[967]	[400,203]	1	hSpCas9	negative selection	1974562
48847368	48847391	3	-	26627737	HCT116	viability after 9 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	0.24964192926971318	[1481]	[422,507]	2	hSpCas9	negative selection	1974563
48847369	48847392	3	-	26627737	HCT116	viability after 9 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	0.6856481613600705	[1280]	[643,475]	5	hSpCas9	negative selection	1974564
48751660	48751683	3	-	26627737	HCT116	viability after 12 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	0.3257084250471738	[521]	[233,464,344]	3	hSpCas9	negative selection	2056874
48752215	48752238	3	+	26627737	HCT116	viability after 12 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	0.18180141284862306	[317]	[167,206,195]	2	hSpCas9	negative selection	2056875
48772971	48772994	3	-	26627737	HCT116	viability after 12 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	0.2053556115429313	[271]	[153,107,231]	2	hSpCas9	negative selection	2056876
48794014	48794037	3	-	26627737	HCT116	viability after 12 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	0.2357494446428275	[387]	[162,236,326]	2	hSpCas9	negative selection	2056877
48847368	48847391	3	-	26627737	HCT116	viability after 12 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	0.3488636865417458	[589]	[285,468,440]	3	hSpCas9	negative selection	2056878
48847369	48847392	3	-	26627737	HCT116	viability after 12 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	0.1655441345627916	[468]	[205,337,292]	1	hSpCas9	negative selection	2056879
48751660	48751683	3	-	26627737	HCT116	viability after 15 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	0.19858873585272185	[521]	[261,408,350]	2	hSpCas9	negative selection	2139189
48752215	48752238	3	+	26627737	HCT116	viability after 15 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	0.41736769546461466	[317]	[149,221,346]	4	hSpCas9	negative selection	2139190
48772971	48772994	3	-	26627737	HCT116	viability after 15 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	-0.3750289182193265	[271]	[109,122,126]	-4	hSpCas9	negative selection	2139191
48794014	48794037	3	-	26627737	HCT116	viability after 15 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	0.3442971833400456	[387]	[320,224,306]	3	hSpCas9	negative selection	2139192
48847368	48847391	3	-	26627737	HCT116	viability after 15 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	0.6557796647119127	[589]	[709,386,525]	6	hSpCas9	negative selection	2139193
48847369	48847392	3	-	26627737	HCT116	viability after 15 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	0.5133351977820482	[468]	[338,439,368]	5	hSpCas9	negative selection	2139194
48751660	48751683	3	-	26627737	HCT116	viability after 18 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	0.5510074878384674	[521]	[268,489,340]	4	hSpCas9	negative selection	2221504
48752215	48752238	3	+	26627737	HCT116	viability after 18 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	0.21878194205716384	[317]	[166,172,197]	2	hSpCas9	negative selection	2221505
48772971	48772994	3	-	26627737	HCT116	viability after 18 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	-1.2768145568265061	[271]	[57,33,72]	-8	hSpCas9	negative selection	2221506
48794014	48794037	3	-	26627737	HCT116	viability after 18 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	0.4169241964838069	[387]	[242,178,337]	3	hSpCas9	negative selection	2221507
48847368	48847391	3	-	26627737	HCT116	viability after 18 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	0.31728800268554713	[589]	[298,405,357]	2	hSpCas9	negative selection	2221508
48847369	48847392	3	-	26627737	HCT116	viability after 18 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	0.15454629318511715	[468]	[157,257,344]	1	hSpCas9	negative selection	2221509
48835225	48835248	3	-	25494202	A375	resistance to PLX-4720 (puromycin)	TGTAATCCCAGCACTTCGGGCGG	PRKAR2A	ENSG00000114302	-3.9690945324429574	[10,229]	[0,1]	-9	dCas9-VP64	positive selection	2383138
48812506	48812529	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	AGACTCTCACTCTGTCGCCCAGG	PRKAR2A	ENSG00000114302	-0.49349443152993966	[60,430]	[31,45]	-2	dCas9-VP64	positive selection	2390901
48815460	48815483	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	GCTGAGGCGGGCGGATCACGGGG	PRKAR2A	ENSG00000114302	3.028184953541963	[9,0]	[15,2]	8	dCas9-VP64	positive selection	2413672
48793548	48793571	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGTGTGAGCCACCATGCCCAG	PRKAR2A	ENSG00000114302	-2.540049325425791	[4,100]	[0,1]	-9	dCas9-VP64	positive selection	2419157
48776795	48776818	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	CGCACCATTGCACTCCAGCCTGG	PRKAR2A	ENSG00000114302	0.4129969310179949	[70,134]	[28,30]	1	dCas9-VP64	positive selection	2420953
48800355	48800378	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	ATACAAAAATTAGCCAGGCGTGG	PRKAR2A	ENSG00000114302	0.7667043826941231	[92,346]	[53,113]	3	dCas9-VP64	positive selection	2426136
48829412	48829435	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	AGGAGGCTGAGGCAGGAGAACAG	PRKAR2A	ENSG00000114302	1.7244712313844854	[32,17]	[27,7]	6	dCas9-VP64	positive selection	2468546
48829066	48829089	3	-	25494202	A375	resistance to PLX-4720 (puromycin)	CAAGGTGGGTGGATCACTTGTGG	PRKAR2A	ENSG00000114302	2.670757623225415	[8,4]	[14,3]	8	dCas9-VP64	positive selection	2471836
48835225	48835248	3	-	25494202	A375	resistance to PLX-4720 (zeocin)	TGTAATCCCAGCACTTCGGGCGG	PRKAR2A	ENSG00000114302	-1.0802329755633977	[58,72]	[5,12]	-9	dCas9-VP64	positive selection	2478393
48812506	48812529	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	AGACTCTCACTCTGTCGCCCAGG	PRKAR2A	ENSG00000114302	-0.2653854437935726	[87,215]	[32,47]	-3	dCas9-VP64	positive selection	2486156
48815460	48815483	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	GCTGAGGCGGGCGGATCACGGGG	PRKAR2A	ENSG00000114302	1.1893121523925974	[28,6]	[25,1]	7	dCas9-VP64	positive selection	2508927
48793548	48793571	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGTGTGAGCCACCATGCCCAG	PRKAR2A	ENSG00000114302	0.03661325214909955	[138,24]	[31,22]	0	dCas9-VP64	positive selection	2514412
48776795	48776818	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	CGCACCATTGCACTCCAGCCTGG	PRKAR2A	ENSG00000114302	0.4348131797167361	[124,104]	[58,42]	3	dCas9-VP64	positive selection	2516208
48800355	48800378	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	ATACAAAAATTAGCCAGGCGTGG	PRKAR2A	ENSG00000114302	0.15255249232697954	[139,139]	[73,28]	1	dCas9-VP64	positive selection	2521391
48829412	48829435	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	AGGAGGCTGAGGCAGGAGAACAG	PRKAR2A	ENSG00000114302	-0.1093774260535414	[64,117]	[17,35]	-1	dCas9-VP64	positive selection	2563801
48829066	48829089	3	-	25494202	A375	resistance to PLX-4720 (zeocin)	CAAGGTGGGTGGATCACTTGTGG	PRKAR2A	ENSG00000114302	0.9990680086899741	[19,33]	[6,26]	6	dCas9-VP64	positive selection	2567091
48765241	48765264	3	+	27013184	SW480	treatment with recombinant TRAIL	ACTTTACCTCTAGTGATTTAAGG	PRKAR2A	ENSG00000114302	3.989423477434751	[73,112]	[843,322]	9	hSpCas9	positive selection	2957943
48752189	48752212	3	+	27013184	SW480	treatment with recombinant TRAIL	ATCTCCAACTGCATAAGCTGAGG	PRKAR2A	ENSG00000114302	2.8718234775819886	[97,241]	[477,571]	9	hSpCas9	positive selection	2957944
48752198	48752221	3	+	27013184	SW480	treatment with recombinant TRAIL	TGCATAAGCTGAGGCAGCTCTGG	PRKAR2A	ENSG00000114302	-0.7533293215256796	[425,395]	[67,158]	-3	hSpCas9	positive selection	2957945
48752245	48752268	3	+	27013184	SW480	treatment with recombinant TRAIL	CTCCAAAGTACTGCCCCTTATGG	PRKAR2A	ENSG00000114302	-1.14655115285667	[550,699]	[99,149]	-5	hSpCas9	positive selection	2957946
48765244	48765267	3	+	27013184	SW480	treatment with recombinant TRAIL	TTACCTCTAGTGATTTAAGGAGG	PRKAR2A	ENSG00000114302	0.8935703677332895	[298,277]	[295,140]	4	hSpCas9	positive selection	2957947
48752251	48752274	3	+	27013184	SW480	treatment with recombinant TRAIL	AGTACTGCCCCTTATGGCAGCGG	PRKAR2A	ENSG00000114302	-0.5217156047301033	[203,144]	[25,91]	-2	hSpCas9	positive selection	2957948
48752252	48752275	3	+	27013184	SW480	treatment with recombinant TRAIL	GTACTGCCCCTTATGGCAGCGGG	PRKAR2A	ENSG00000114302	0.29620813367725	[86,295]	[110,75]	1	hSpCas9	positive selection	2957949
48752305	48752328	3	+	27013184	SW480	treatment with recombinant TRAIL	TGTTTGATTTAGTCTACAGCAGG	PRKAR2A	ENSG00000114302	0.9992412460656277	[139,123]	[111,117]	5	hSpCas9	positive selection	2957950
48790585	48790608	3	-	27013184	SW480	treatment with recombinant TRAIL	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.05456710595860903	[40,30]	[3,30]	0	hSpCas9	positive selection	2957951
48794014	48794037	3	-	27013184	SW480	treatment with recombinant TRAIL	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	-0.826586129090211	[188,203]	[71,12]	-4	hSpCas9	positive selection	2957952
48765245	48765268	3	+	27013184	SW480	treatment with recombinant TRAIL	TACCTCTAGTGATTTAAGGAGGG	PRKAR2A	ENSG00000114302	0.34645855225802347	[9,103]	[35,18]	1	hSpCas9	positive selection	2957953
48765247	48765270	3	-	27013184	SW480	treatment with recombinant TRAIL	GCCCCTCCTTAAATCACTAGAGG	PRKAR2A	ENSG00000114302	1.3063740058492994	[117,65]	[20,213]	6	hSpCas9	positive selection	2957955
48765343	48765366	3	-	27013184	SW480	treatment with recombinant TRAIL	ATATTCTTTCTTGTAGGACCGGG	PRKAR2A	ENSG00000114302	2.1173113142168276	[35,29]	[65,56]	8	hSpCas9	positive selection	2957956
48765344	48765367	3	-	27013184	SW480	treatment with recombinant TRAIL	CATATTCTTTCTTGTAGGACCGG	PRKAR2A	ENSG00000114302	0.19761250950860557	[151,166]	[97,50]	1	hSpCas9	positive selection	2957957
48765349	48765372	3	-	27013184	SW480	treatment with recombinant TRAIL	ATTTTCATATTCTTTCTTGTAGG	PRKAR2A	ENSG00000114302	-2.4633113852227524	[232,136]	[20,5]	-8	hSpCas9	positive selection	2957958
48765246	48765269	3	+	27013184	SW480	treatment with recombinant TRAIL	ACCTCTAGTGATTTAAGGAGGGG	PRKAR2A	ENSG00000114302	-0.6494630219186757	[171,413]	[75,79]	-3	hSpCas9	positive selection	2957959
48765325	48765348	3	+	27013184	SW480	treatment with recombinant TRAIL	TGATTCTTCTAAAAGTCACCCGG	PRKAR2A	ENSG00000114302	0.2208888088034593	[81,106]	[8,100]	1	hSpCas9	positive selection	2957961
48752193	48752216	3	-	27013184	SW480	treatment with recombinant TRAIL	GCTGCCTCAGCTTATGCAGTTGG	PRKAR2A	ENSG00000114302	1.4898262194042342	[178,415]	[379,301]	7	hSpCas9	positive selection	2957962
48752233	48752256	3	-	27013184	SW480	treatment with recombinant TRAIL	GTACTTTGGAGAGCTTGCCCTGG	PRKAR2A	ENSG00000114302	-0.4863859091438234	[320,265]	[98,79]	-2	hSpCas9	positive selection	2957964
48752247	48752270	3	-	27013184	SW480	treatment with recombinant TRAIL	TGCCATAAGGGGCAGTACTTTGG	PRKAR2A	ENSG00000114302	0.007886341663645755	[168,237]	[48,140]	0	hSpCas9	positive selection	2957965
48752258	48752281	3	-	27013184	SW480	treatment with recombinant TRAIL	AGATTGCCCGCTGCCATAAGGGG	PRKAR2A	ENSG00000114302	-2.758012624793544	[1458,1840]	[52,176]	-8	hSpCas9	positive selection	2957966
48752259	48752282	3	-	27013184	SW480	treatment with recombinant TRAIL	GAGATTGCCCGCTGCCATAAGGG	PRKAR2A	ENSG00000114302	-0.06595281743650117	[718,936]	[260,445]	0	hSpCas9	positive selection	2957967
48752260	48752283	3	-	27013184	SW480	treatment with recombinant TRAIL	CGAGATTGCCCGCTGCCATAAGG	PRKAR2A	ENSG00000114302	-1.6750039831347814	[1249,1251]	[147,198]	-6	hSpCas9	positive selection	2957968
48752294	48752317	3	-	27013184	SW480	treatment with recombinant TRAIL	CTAAATCAAACAAGGATGGTGGG	PRKAR2A	ENSG00000114302	-4.714473328856751	[102,143]	[1,1]	-9	hSpCas9	positive selection	2957969
48752295	48752318	3	-	27013184	SW480	treatment with recombinant TRAIL	ACTAAATCAAACAAGGATGGTGG	PRKAR2A	ENSG00000114302	0.8769372321085425	[118,48]	[106,14]	4	hSpCas9	positive selection	2957970
48752298	48752321	3	-	27013184	SW480	treatment with recombinant TRAIL	TAGACTAAATCAAACAAGGATGG	PRKAR2A	ENSG00000114302	-0.5003584962072898	[1,11]	[1,1]	-2	hSpCas9	positive selection	2957971
48794008	48794031	3	+	27013184	SW480	treatment with recombinant TRAIL	TATCTTCCTCTTCCTCATCAGGG	PRKAR2A	ENSG00000114302	-0.48667853894178204	[340,384]	[78,156]	-2	hSpCas9	positive selection	2957972
48752302	48752325	3	-	27013184	SW480	treatment with recombinant TRAIL	GCTGTAGACTAAATCAAACAAGG	PRKAR2A	ENSG00000114302	-0.9541156199704308	[9,176]	[19,17]	-4	hSpCas9	positive selection	2957973
48847492	48847515	3	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	ACTCCACTGCGAATTCGACGAGG	PRKAR2A	ENSG00000114302	0.12939020880973623	[3,3]	[2,3]	2	hSpCas9	positive selection	3013649
48847500	48847523	3	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCGAATTCGACGAGGTCAGGCGG	PRKAR2A	ENSG00000114302	0.3842550409292939	[3,2]	[2,3]	7	hSpCas9	positive selection	3013650
48773040	48773063	3	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	0.12223514247848782	[2,1]	[2,1]	2	hSpCas9	positive selection	3013651
48847494	48847517	3	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	0.5409617762312477	[1,2]	[2,2]	9	hSpCas9	positive selection	3013652
48847492	48847515	3	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	ACTCCACTGCGAATTCGACGAGG	PRKAR2A	ENSG00000114302	0.03354163039804117	[3,3]	[3,1]	0	hSpCas9	positive selection	3081507
48847500	48847523	3	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCGAATTCGACGAGGTCAGGCGG	PRKAR2A	ENSG00000114302	-0.6093095375078752	[3,3]	[1,0]	-8	hSpCas9	positive selection	3081508
48773040	48773063	3	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	-0.4558478536629816	[2,2]	[1,0]	-6	hSpCas9	positive selection	3081509
48847494	48847517	3	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	1.7598489561876351	[1,1]	[2,7]	9	hSpCas9	positive selection	3081510
48790543	48790566		+	24336571	A375	resistance to PLX after 7 days	CCTGATCAAGATTTTTGAAAAGG	PRKAR2A	ENSG00000114302	-0.49344964972769323	[4,2]	[2,1]	-9	hSpCas9	positive selection	3137774
48790543	48790566		-	24336571	A375	resistance to PLX after 7 days	CCTTTTCAAAAATCTTGATCAGG	PRKAR2A	ENSG00000114302	0.2337672646976181	[3,3]	[5,3]	7	hSpCas9	positive selection	3137775
48783019	48783042		-	24336571	A375	resistance to PLX after 7 days	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.09517260199845606	[16,19]	[15,17]	-3	hSpCas9	positive selection	3137776
48790585	48790608		-	24336571	A375	resistance to PLX after 7 days	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.0545712876685146	[6,8]	[7,7]	-1	hSpCas9	positive selection	3137777
48783054	48783077		-	24336571	A375	resistance to PLX after 7 days	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	-0.14116363154562728	[28,33]	[26,28]	-4	hSpCas9	positive selection	3137778
48783045	48783068		+	24336571	A375	resistance to PLX after 7 days	TTTGACTATCCTTTCAAACATGG	PRKAR2A	ENSG00000114302	-0.27493309759654305	[10,10]	[8,7]	-7	hSpCas9	positive selection	3137779
48790543	48790566		+	24336571	A375	resistance to PLX after 14 days	CCTGATCAAGATTTTTGAAAAGG	PRKAR2A	ENSG00000114302	-0.08718880242100613	[5,5]	[1,2]	-1	hSpCas9	positive selection	3195567
48790543	48790566		-	24336571	A375	resistance to PLX after 14 days	CCTTTTCAAAAATCTTGATCAGG	PRKAR2A	ENSG00000114302	1.6605532290893412	[1,3]	[3,4]	9	hSpCas9	positive selection	3195568
48783019	48783042		-	24336571	A375	resistance to PLX after 14 days	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.32809009814279444	[20,13]	[6,4]	-4	hSpCas9	positive selection	3195569
48790585	48790608		-	24336571	A375	resistance to PLX after 14 days	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.28226428126715675	[9,9]	[2,3]	-3	hSpCas9	positive selection	3195570
48783054	48783077		-	24336571	A375	resistance to PLX after 14 days	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	-0.28652833226551566	[28,35]	[11,11]	-3	hSpCas9	positive selection	3195571
48783045	48783068		+	24336571	A375	resistance to PLX after 14 days	TTTGACTATCCTTTCAAACATGG	PRKAR2A	ENSG00000114302	0.20029905023675112	[9,10]	[3,5]	2	hSpCas9	positive selection	3195572
48790543	48790566		+	24336571	A375	viability after 7 days	CCTGATCAAGATTTTTGAAAAGG	PRKAR2A	ENSG00000114302	-0.5084089595145549	[5]	[4,2]	-6	hSpCas9	negative selection	3253360
48790543	48790566		-	24336571	A375	viability after 7 days	CCTTTTCAAAAATCTTGATCAGG	PRKAR2A	ENSG00000114302	-0.30121109887739506	[4]	[3,3]	-4	hSpCas9	negative selection	3253361
48783019	48783042		-	24336571	A375	viability after 7 days	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	0.051739320629367425	[18]	[16,19]	0	hSpCas9	negative selection	3253362
48790585	48790608		-	24336571	A375	viability after 7 days	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	0.28513389394088007	[6]	[6,8]	4	hSpCas9	negative selection	3253363
48783054	48783077		-	24336571	A375	viability after 7 days	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.8955108178931193	[16]	[28,33]	9	hSpCas9	negative selection	3253364
48783045	48783068		+	24336571	A375	viability after 7 days	TTTGACTATCCTTTCAAACATGG	PRKAR2A	ENSG00000114302	-0.06426789382954837	[11]	[10,10]	-1	hSpCas9	negative selection	3253365
48790543	48790566		+	24336571	A375	viability after 14 days	CCTGATCAAGATTTTTGAAAAGG	PRKAR2A	ENSG00000114302	0.010082538868788182	[5]	[5,5]	0	hSpCas9	negative selection	3311153
48790543	48790566		-	24336571	A375	viability after 14 days	CCTTTTCAAAAATCTTGATCAGG	PRKAR2A	ENSG00000114302	-0.6586625464629976	[4]	[1,3]	-7	hSpCas9	negative selection	3311154
48783019	48783042		-	24336571	A375	viability after 14 days	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.014602349820683258	[18]	[20,13]	0	hSpCas9	negative selection	3311155
48790585	48790608		-	24336571	A375	viability after 14 days	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	0.5726225676846184	[6]	[9,9]	7	hSpCas9	negative selection	3311156
48783054	48783077		-	24336571	A375	viability after 14 days	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.9514610831844106	[16]	[28,35]	9	hSpCas9	negative selection	3311157
48783045	48783068		+	24336571	A375	viability after 14 days	TTTGACTATCCTTTCAAACATGG	PRKAR2A	ENSG00000114302	-0.07115610617275434	[11]	[9,10]	-1	hSpCas9	negative selection	3311158
48783054	48783077	3	-	27383988	293T	resistance to West Nile virus (flavivirus)	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	-0.8924209080588471	[283,283]	[0,0]	-6	hSpCas9	positive selection	3387471
48790585	48790608	3	-	27383988	293T	resistance to West Nile virus (flavivirus)	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.13499121133292535	[167,167]	[0,0]	-1	hSpCas9	positive selection	3387472
48772970	48772993	3	+	27383988	293T	resistance to West Nile virus (flavivirus)	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	-0.09140194278524241	[162,162]	[0,0]	0	hSpCas9	positive selection	3387473
48847491	48847514	3	+	26780180	HT29	viability (Avana library 4 designs)	ACTCCACTGCGAATTCGACGAGG	PRKAR2A	ENSG00000114302	1.91001427362395	[]	[]	7	hSpCas9	negative selection	3451836
48847499	48847522	3	+	26780180	HT29	viability (Avana library 4 designs)	GCGAATTCGACGAGGTCAGGCGG	PRKAR2A	ENSG00000114302	1.17347080727924	[]	[]	4	hSpCas9	negative selection	3451837
48773040	48773063	3	-	26780180	HT29	viability (Avana library 4 designs)	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	1.59867265340045	[]	[]	6	hSpCas9	negative selection	3451838
48847494	48847517	3	-	26780180	HT29	viability (Avana library 4 designs)	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	2.37295860181768	[]	[]	8	hSpCas9	negative selection	3451839
48847491	48847514	3	+	26780180	A375	viability (Avana lentiCRISPRv2)	ACTCCACTGCGAATTCGACGAGG	PRKAR2A	ENSG00000114302	-1.34268850444319	[]	[]	-2	hSpCas9	negative selection	3547922
48847499	48847522	3	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCGAATTCGACGAGGTCAGGCGG	PRKAR2A	ENSG00000114302	0.558092724589095	[]	[]	0	hSpCas9	negative selection	3547923
48847494	48847517	3	-	26780180	A375	viability (Avana lentiCRISPRv2)	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	-5.42861032650368	[]	[]	-5	hSpCas9	negative selection	3547924
48773040	48773063	3	-	26780180	A375	viability (Avana lentiCRISPRv2)	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	4.33045530630312	[]	[]	7	hSpCas9	negative selection	3547925
48847491	48847514	3	+	26780180	A375	viability (Avana lentiGuide)	ACTCCACTGCGAATTCGACGAGG	PRKAR2A	ENSG00000114302	2.18480666441467	[]	[]	2	hSpCas9	negative selection	3656581
48847499	48847522	3	+	26780180	A375	viability (Avana lentiGuide)	GCGAATTCGACGAGGTCAGGCGG	PRKAR2A	ENSG00000114302	9.37149685346964	[]	[]	6	hSpCas9	negative selection	3656582
48847494	48847517	3	-	26780180	A375	viability (Avana lentiGuide)	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	24.8896207766422	[]	[]	9	hSpCas9	negative selection	3656583
48773040	48773063	3	-	26780180	A375	viability (Avana lentiGuide)	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	6.8735064733427	[]	[]	5	hSpCas9	negative selection	3656584
48847491	48847514	3	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ACTCCACTGCGAATTCGACGAGG	PRKAR2A	ENSG00000114302	-0.7042626519704203	[4]	[3,1]	-7	hSpCas9	positive selection	3765188
48847499	48847522	3	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCGAATTCGACGAGGTCAGGCGG	PRKAR2A	ENSG00000114302	0.4294313651846152	[4]	[5,5]	9	hSpCas9	positive selection	3765189
48847494	48847517	3	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	-0.7621829911046754	[4]	[3,0]	-8	hSpCas9	positive selection	3765190
48773040	48773063	3	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	0.3236287493113296	[4]	[4,5]	8	hSpCas9	positive selection	3765191
48847491	48847514	3	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ACTCCACTGCGAATTCGACGAGG	PRKAR2A	ENSG00000114302	-0.059764343237957276	[5]	[5,3]	-1	hSpCas9	positive selection	3873795
48847499	48847522	3	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCGAATTCGACGAGGTCAGGCGG	PRKAR2A	ENSG00000114302	-0.6161394292967833	[5]	[2,2]	-7	hSpCas9	positive selection	3873796
48847494	48847517	3	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	-0.8567743784792983	[3]	[2,0]	-8	hSpCas9	positive selection	3873797
48773040	48773063	3	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	-0.4002610600383247	[4]	[1,3]	-5	hSpCas9	positive selection	3873798
48773058	48773081	3	-	26780180	A375	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	1.00690326423433	[]	[]	4	hSpCas9	negative selection	3984247
48783019	48783042	3	-	26780180	A375	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	0.932323504132532	[]	[]	4	hSpCas9	negative selection	3984248
48772970	48772993	3	+	26780180	A375	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.708943148380202	[]	[]	2	hSpCas9	negative selection	3984249
48773031	48773054	3	-	26780180	A375	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.365166715023273	[]	[]	0	hSpCas9	negative selection	3984250
48790585	48790608	3	-	26780180	A375	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	1.74699804334375	[]	[]	9	hSpCas9	negative selection	3984251
48783054	48783077	3	-	26780180	A375	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.685715056175125	[]	[]	2	hSpCas9	negative selection	3984252
48773058	48773081	3	-	26780180	HT29	viability (GeCKOv2 library)	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	1.18214350661063	[]	[]	6	hSpCas9	negative selection	4092213
48783019	48783042	3	-	26780180	HT29	viability (GeCKOv2 library)	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	0.639536024990955	[]	[]	2	hSpCas9	negative selection	4092214
48772970	48772993	3	+	26780180	HT29	viability (GeCKOv2 library)	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	1.2756722107652	[]	[]	6	hSpCas9	negative selection	4092215
48773031	48773054	3	-	26780180	HT29	viability (GeCKOv2 library)	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.114732572038424	[]	[]	0	hSpCas9	negative selection	4092216
48790585	48790608	3	-	26780180	HT29	viability (GeCKOv2 library)	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	1.23430867419321	[]	[]	6	hSpCas9	negative selection	4092217
48783054	48783077	3	-	26780180	HT29	viability (GeCKOv2 library)	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.855298564998215	[]	[]	3	hSpCas9	negative selection	4092218
48790543	48790566	3	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CCTGATCAAGATTTTTGAAAAGG	PRKAR2A	ENSG00000114302	-0.3520773158108793	[2]	[0,0]	-7	hSpCas9	positive selection	4162929
48790543	48790566	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CCTTTTCAAAAATCTTGATCAGG	PRKAR2A	ENSG00000114302	0.521654967756389	[1]	[0,1]	9	hSpCas9	positive selection	4162930
48783019	48783042	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.131307397931002	[4]	[2,2]	-3	hSpCas9	positive selection	4162931
48790585	48790608	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.275369984653865	[3]	[1,1]	-6	hSpCas9	positive selection	4162932
48783054	48783077	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.11689078240855705	[4]	[3,3]	3	hSpCas9	positive selection	4162933
48783045	48783068	3	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TTTGACTATCCTTTCAAACATGG	PRKAR2A	ENSG00000114302	-0.0651569241529445	[3]	[1,2]	-1	hSpCas9	positive selection	4162934
48790543	48790566	3	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CCTGATCAAGATTTTTGAAAAGG	PRKAR2A	ENSG00000114302	1.7424037889542148	[0]	[2,3,0,0]	9	hSpCas9	positive selection	4226951
48790543	48790566	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CCTTTTCAAAAATCTTGATCAGG	PRKAR2A	ENSG00000114302	0.864484807500188	[1]	[1,0,3,0]	5	hSpCas9	positive selection	4226952
48783019	48783042	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	1.0362569773853272	[4]	[3,2,4,3]	7	hSpCas9	positive selection	4226953
48790585	48790608	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.3518006455605789	[3]	[0,1,0,0]	-5	hSpCas9	positive selection	4226954
48783054	48783077	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	1.4425498586712797	[3]	[1,5,2,5]	9	hSpCas9	positive selection	4226955
48783045	48783068	3	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TTTGACTATCCTTTCAAACATGG	PRKAR2A	ENSG00000114302	0.14454568214799995	[4]	[4,4,0,0]	1	hSpCas9	positive selection	4226956
48773058	48773081	3	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	-0.20964599682864166	[2]	[3,0]	-4	hSpCas9	positive selection	4292162
48773031	48773054	3	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.46003817667679886	[4]	[4,4]	8	hSpCas9	positive selection	4292163
48783019	48783042	3	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	0.13176932267270675	[3]	[3,2]	2	hSpCas9	positive selection	4292164
48783054	48783077	3	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.24817240934894969	[3]	[3,2]	5	hSpCas9	positive selection	4356420
48790585	48790608	3	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	0.11719386056079242	[3]	[3,2]	2	hSpCas9	positive selection	4356421
48772970	48772993	3	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	-0.020133810712775535	[2]	[3,0]	0	hSpCas9	positive selection	4356422
48847368	48847390	3	-	27760321	OCIAML3	viability	CGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	-0.45441250189916255	[425,316]	[161,272]	-4	hSpCas9	negative selection	4430585
48847470	48847492	3	-	27760321	OCIAML3	viability	TACTTCACCCGCCTGCGCGAGG	PRKAR2A	ENSG00000114302	0.07137011202875154	[2010,1684]	[1331,1747]	0	hSpCas9	negative selection	4430586
48773040	48773062	3	-	27760321	OCIAML3	viability	TTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	-0.42081062139247116	[299,256]	[156,168]	-4	hSpCas9	negative selection	4430587
48782981	48783003	3	-	27760321	OCIAML3	viability	TTTTATGTCATAGAACGGTAGG	PRKAR2A	ENSG00000114302	1.5384434133948295	[30,32]	[40,114]	9	hSpCas9	negative selection	4430588
48783046	48783068	3	+	27760321	OCIAML3	viability	TTGACTATCCTTTCAAACATGG	PRKAR2A	ENSG00000114302	-1.4720799901709545	[32,55]	[1,26]	-8	hSpCas9	negative selection	4430589
48847368	48847390	3	-	27760321	OCIAML2	viability	CGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	0.027915361294156754	[425,316]	[323,276]	0	hSpCas9	negative selection	4514048
48847470	48847492	3	-	27760321	OCIAML2	viability	TACTTCACCCGCCTGCGCGAGG	PRKAR2A	ENSG00000114302	0.36046606120369606	[2010,1684]	[1663,2237]	5	hSpCas9	negative selection	4514049
48773040	48773062	3	-	27760321	OCIAML2	viability	TTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	0.6192370571506588	[299,256]	[259,456]	8	hSpCas9	negative selection	4514050
48782981	48783003	3	-	27760321	OCIAML2	viability	TTTTATGTCATAGAACGGTAGG	PRKAR2A	ENSG00000114302	1.2577069279428899	[30,32]	[44,84]	9	hSpCas9	negative selection	4514051
48783046	48783068	3	+	27760321	OCIAML2	viability	TTGACTATCCTTTCAAACATGG	PRKAR2A	ENSG00000114302	1.2607457774512936	[32,55]	[33,159]	9	hSpCas9	negative selection	4514052
48847368	48847390	3	-	27760321	MV411	viability	CGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	-1.7193774551554262	[425,316]	[68,80]	-8	hSpCas9	negative selection	4597511
48847470	48847492	3	-	27760321	MV411	viability	TACTTCACCCGCCTGCGCGAGG	PRKAR2A	ENSG00000114302	0.07824342408000406	[2010,1684]	[761,2063]	0	hSpCas9	negative selection	4597512
48773040	48773062	3	-	27760321	MV411	viability	TTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	1.3248337527635936	[299,256]	[430,500]	8	hSpCas9	negative selection	4597513
48782981	48783003	3	-	27760321	MV411	viability	TTTTATGTCATAGAACGGTAGG	PRKAR2A	ENSG00000114302	-4.408735500133068	[30,32]	[0,0]	-9	hSpCas9	negative selection	4597514
48783046	48783068	3	+	27760321	MV411	viability	TTGACTATCCTTTCAAACATGG	PRKAR2A	ENSG00000114302	1.5816259553052243	[32,55]	[145,5]	9	hSpCas9	negative selection	4597515
48847368	48847390	3	-	27760321	HL60	viability	CGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	-0.5305387882973294	[425,316]	[199,216]	-5	hSpCas9	negative selection	4680974
48847470	48847492	3	-	27760321	HL60	viability	TACTTCACCCGCCTGCGCGAGG	PRKAR2A	ENSG00000114302	0.09730683462387058	[2010,1684]	[1592,1624]	1	hSpCas9	negative selection	4680975
48773040	48773062	3	-	27760321	HL60	viability	TTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	-0.11957295458820494	[299,256]	[200,216]	-1	hSpCas9	negative selection	4680976
48782981	48783003	3	-	27760321	HL60	viability	TTTTATGTCATAGAACGGTAGG	PRKAR2A	ENSG00000114302	-2.9032269522418312	[30,32]	[3,2]	-9	hSpCas9	negative selection	4680977
48783046	48783068	3	+	27760321	HL60	viability	TTGACTATCCTTTCAAACATGG	PRKAR2A	ENSG00000114302	0.8224396591637002	[32,55]	[27,105]	8	hSpCas9	negative selection	4680978
48847368	48847390	3	-	27760321	HT1080	viability	CGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	-1.640813620684035	[316,247]	[16,56]	-5	hSpCas9	negative selection	4764437
48847470	48847492	3	-	27760321	HT1080	viability	TACTTCACCCGCCTGCGCGAGG	PRKAR2A	ENSG00000114302	-0.8922727637645558	[1684,1314]	[541,80]	-4	hSpCas9	negative selection	4764438
48773040	48773062	3	-	27760321	HT1080	viability	TTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	-1.271206395099693	[256,200]	[1,76]	-5	hSpCas9	negative selection	4764439
48782981	48783003	3	-	27760321	HT1080	viability	TTTTATGTCATAGAACGGTAGG	PRKAR2A	ENSG00000114302	6.128130945842133	[32,25]	[652,1007]	9	hSpCas9	negative selection	4764440
48783046	48783068	3	+	27760321	HT1080	viability	TTGACTATCCTTTCAAACATGG	PRKAR2A	ENSG00000114302	1.7557397329956772	[55,43]	[83,48]	8	hSpCas9	negative selection	4764441
48847368	48847390	3	-	27760321	HT29	viability after 7 days	CGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	-0.26526422865799826	[316,247]	[208,348,333]	-4	hSpCas9	negative selection	4847900
48847470	48847492	3	-	27760321	HT29	viability after 7 days	TACTTCACCCGCCTGCGCGAGG	PRKAR2A	ENSG00000114302	-0.1647809977822614	[1684,1314]	[2172,1671,1388]	-2	hSpCas9	negative selection	4847901
48773040	48773062	3	-	27760321	HT29	viability after 7 days	TTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	-0.5287974950257761	[256,200]	[97,202,292]	-6	hSpCas9	negative selection	4847902
48782981	48783003	3	-	27760321	HT29	viability after 7 days	TTTTATGTCATAGAACGGTAGG	PRKAR2A	ENSG00000114302	-2.714385895478215	[32,25]	[2,9,3]	-9	hSpCas9	negative selection	4847903
48783046	48783068	3	+	27760321	HT29	viability after 7 days	TTGACTATCCTTTCAAACATGG	PRKAR2A	ENSG00000114302	-1.2588254069557876	[55,43]	[60,14,9]	-9	hSpCas9	negative selection	4847904
48847368	48847390	3	-	27760321	HT29	viability after 25 days	CGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	-0.10803210221448761	[316,247]	[260,208,445]	-1	hSpCas9	negative selection	4931363
48847470	48847492	3	-	27760321	HT29	viability after 25 days	TACTTCACCCGCCTGCGCGAGG	PRKAR2A	ENSG00000114302	0.05782887695335237	[1684,1314]	[1698,1929,1719]	0	hSpCas9	negative selection	4931364
48773040	48773062	3	-	27760321	HT29	viability after 25 days	TTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	-0.24377070929017808	[256,200]	[109,181,395]	-3	hSpCas9	negative selection	4931365
48782981	48783003	3	-	27760321	HT29	viability after 25 days	TTTTATGTCATAGAACGGTAGG	PRKAR2A	ENSG00000114302	-1.4530520338631678	[32,25]	[0,29,5]	-7	hSpCas9	negative selection	4931366
48783046	48783068	3	+	27760321	HT29	viability after 25 days	TTGACTATCCTTTCAAACATGG	PRKAR2A	ENSG00000114302	0.1929964861515061	[55,43]	[55,96,40]	2	hSpCas9	negative selection	4931367
48847368	48847390	3	-	27760321	HT29	viability after 22 days	CGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	-0.5170273552005381	[316,247]	[268,149,264]	-5	hSpCas9	negative selection	5014826
48847470	48847492	3	-	27760321	HT29	viability after 22 days	TACTTCACCCGCCTGCGCGAGG	PRKAR2A	ENSG00000114302	0.007523535224100986	[1684,1314]	[1750,1851,1624]	0	hSpCas9	negative selection	5014827
48773040	48773062	3	-	27760321	HT29	viability after 22 days	TTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	0.10134782118677566	[256,200]	[98,275,483]	1	hSpCas9	negative selection	5014828
48782981	48783003	3	-	27760321	HT29	viability after 22 days	TTTTATGTCATAGAACGGTAGG	PRKAR2A	ENSG00000114302	0.3893839699572341	[32,25]	[0,12,121]	4	hSpCas9	negative selection	5014829
48783046	48783068	3	+	27760321	HT29	viability after 22 days	TTGACTATCCTTTCAAACATGG	PRKAR2A	ENSG00000114302	-0.45853482846302107	[55,43]	[79,25,18]	-4	hSpCas9	negative selection	5014830
48847368	48847390	3	-	27760321	HT29	viability after 19 days	CGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	-0.1274447879081494	[316,247]	[519,48,339]	-1	hSpCas9	negative selection	5098289
48847470	48847492	3	-	27760321	HT29	viability after 19 days	TACTTCACCCGCCTGCGCGAGG	PRKAR2A	ENSG00000114302	0.01584720729330602	[1684,1314]	[1715,1742,1740]	0	hSpCas9	negative selection	5098290
48773040	48773062	3	-	27760321	HT29	viability after 19 days	TTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	-0.4869781197862937	[256,200]	[126,312,116]	-4	hSpCas9	negative selection	5098291
48782981	48783003	3	-	27760321	HT29	viability after 19 days	TTTTATGTCATAGAACGGTAGG	PRKAR2A	ENSG00000114302	-2.5142680760771494	[32,25]	[1,0,13]	-8	hSpCas9	negative selection	5098292
48783046	48783068	3	+	27760321	HT29	viability after 19 days	TTGACTATCCTTTCAAACATGG	PRKAR2A	ENSG00000114302	-1.2211096096391505	[55,43]	[29,14,28]	-7	hSpCas9	negative selection	5098293
48847368	48847390	3	-	27760321	HT29	viability after 16 days	CGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	-0.603042485608058	[316,247]	[266,164,198]	-5	hSpCas9	negative selection	5181752
48847470	48847492	3	-	27760321	HT29	viability after 16 days	TACTTCACCCGCCTGCGCGAGG	PRKAR2A	ENSG00000114302	-0.3040675931653527	[1684,1314]	[1357,1378,1339]	-3	hSpCas9	negative selection	5181753
48773040	48773062	3	-	27760321	HT29	viability after 16 days	TTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	-0.3861361386208959	[256,200]	[147,181,253]	-4	hSpCas9	negative selection	5181754
48782981	48783003	3	-	27760321	HT29	viability after 16 days	TTTTATGTCATAGAACGGTAGG	PRKAR2A	ENSG00000114302	-1.4225722076949818	[32,25]	[0,7,26]	-8	hSpCas9	negative selection	5181755
48783046	48783068	3	+	27760321	HT29	viability after 16 days	TTGACTATCCTTTCAAACATGG	PRKAR2A	ENSG00000114302	-0.29959146663069314	[55,43]	[54,56,24]	-3	hSpCas9	negative selection	5181756
48847368	48847390	3	-	27760321	HT29	viability after 13 days	CGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	-0.6967569242270722	[316,247]	[209,251,147]	-6	hSpCas9	negative selection	5265215
48847470	48847492	3	-	27760321	HT29	viability after 13 days	TACTTCACCCGCCTGCGCGAGG	PRKAR2A	ENSG00000114302	-0.02097903349016228	[1684,1314]	[1330,1985,1821]	0	hSpCas9	negative selection	5265216
48773040	48773062	3	-	27760321	HT29	viability after 13 days	TTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	-0.37995857458585713	[256,200]	[78,264,264]	-4	hSpCas9	negative selection	5265217
48782981	48783003	3	-	27760321	HT29	viability after 13 days	TTTTATGTCATAGAACGGTAGG	PRKAR2A	ENSG00000114302	-1.9418337601767464	[32,25]	[1,2,20]	-8	hSpCas9	negative selection	5265218
48783046	48783068	3	+	27760321	HT29	viability after 13 days	TTGACTATCCTTTCAAACATGG	PRKAR2A	ENSG00000114302	-0.3079631299241057	[55,43]	[13,67,57]	-4	hSpCas9	negative selection	5265219
48847368	48847390	3	-	27760321	HT29	viability after 10 days	CGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	-0.37700017832694976	[316,247]	[183,292,336]	-5	hSpCas9	negative selection	5348678
48847470	48847492	3	-	27760321	HT29	viability after 10 days	TACTTCACCCGCCTGCGCGAGG	PRKAR2A	ENSG00000114302	-0.01790388460349046	[1684,1314]	[1911,2124,1526]	0	hSpCas9	negative selection	5348679
48773040	48773062	3	-	27760321	HT29	viability after 10 days	TTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	-0.8892789015543487	[256,200]	[162,127,170]	-7	hSpCas9	negative selection	5348680
48782981	48783003	3	-	27760321	HT29	viability after 10 days	TTTTATGTCATAGAACGGTAGG	PRKAR2A	ENSG00000114302	-1.362544046367458	[32,25]	[1,39,1]	-8	hSpCas9	negative selection	5348681
48783046	48783068	3	+	27760321	HT29	viability after 10 days	TTGACTATCCTTTCAAACATGG	PRKAR2A	ENSG00000114302	0.04053574760837897	[55,43]	[118,65,8]	0	hSpCas9	negative selection	5348682
48847368	48847390	3	-	27760321	MOLM13	viability	CGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	-0.5415361364056381	[425,316]	[273,30]	-3	hSpCas9	negative selection	5432141
48847470	48847492	3	-	27760321	MOLM13	viability	TACTTCACCCGCCTGCGCGAGG	PRKAR2A	ENSG00000114302	1.0081663093375797	[2010,1684]	[2884,1410]	7	hSpCas9	negative selection	5432142
48773040	48773062	3	-	27760321	MOLM13	viability	TTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	0.3241209691806391	[299,256]	[234,162]	2	hSpCas9	negative selection	5432143
48782981	48783003	3	-	27760321	MOLM13	viability	TTTTATGTCATAGAACGGTAGG	PRKAR2A	ENSG00000114302	-4.182678687305473	[30,32]	[0,0]	-9	hSpCas9	negative selection	5432144
48783046	48783068	3	+	27760321	MOLM13	viability	TTGACTATCCTTTCAAACATGG	PRKAR2A	ENSG00000114302	-1.586924687937573	[32,55]	[0,14]	-7	hSpCas9	negative selection	5432145
48847435	48847458	3	+	27661255	K562	viability	GGTGGCGGCGGGCAGGACTGAGG	PRKAR2A	ENSG00000114302	-0.03336125004920855	[861,689]	[734,499]	-1	dCas9-KRAB	negative selection	5504139
48773058	48773081	3	-	27260156	BXPC3	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	-0.17909272336867743	[383]	[318,350,361,392]	-4	hSpCas9	negative selection	5564622
48773031	48773054	3	-	27260156	BXPC3	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.4037089193897896	[1195]	[1567,1608,1515,1959]	8	hSpCas9	negative selection	5564623
48783019	48783042	3	-	27260156	BXPC3	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	0.05296763298274543	[898]	[811,796,1086,1263]	1	hSpCas9	negative selection	5564624
48783054	48783077	3	-	27260156	BXPC3	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.17193879549135416	[584]	[668,578,838,673]	4	hSpCas9	negative selection	5628880
48790585	48790608	3	-	27260156	BXPC3	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.11764947679770033	[723]	[630,650,695,834]	-3	hSpCas9	negative selection	5628881
48772970	48772993	3	+	27260156	BXPC3	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.634745932113997	[340]	[593,494,547,574]	9	hSpCas9	negative selection	5628882
48773058	48773081	3	-	27260156	A673	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	-0.05040273743293744	[383]	[505,545,330,399]	-1	hSpCas9	negative selection	5685873
48773031	48773054	3	-	27260156	A673	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.21640179479740929	[1195]	[1902,1570,1604,1618]	5	hSpCas9	negative selection	5685874
48783019	48783042	3	-	27260156	A673	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	0.26979861159105156	[898]	[1353,1273,1179,1408]	6	hSpCas9	negative selection	5685875
48783054	48783077	3	-	27260156	A673	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.2771664552327893	[584]	[950,747,942,769]	6	hSpCas9	negative selection	5750131
48790585	48790608	3	-	27260156	A673	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	0.04275257844751268	[723]	[866,890,903,915]	1	hSpCas9	negative selection	5750132
48772970	48772993	3	+	27260156	A673	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.4250283328510109	[340]	[565,490,459,692]	8	hSpCas9	negative selection	5750133
48773058	48773081	3	-	27260156	A375	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	0.01581128316054442	[383]	[431,431,279,641]	0	hSpCas9	negative selection	5807124
48773031	48773054	3	-	27260156	A375	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.6170945536524621	[1195]	[1870,2693,2320,1792]	8	hSpCas9	negative selection	5807125
48783019	48783042	3	-	27260156	A375	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.2370263681936463	[898]	[968,1145,910,604]	-3	hSpCas9	negative selection	5807126
48783054	48783077	3	-	27260156	A375	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.1506387455060869	[584]	[661,1110,757,570]	2	hSpCas9	negative selection	5871382
48790585	48790608	3	-	27260156	A375	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.26562779162522626	[723]	[799,673,855,501]	-4	hSpCas9	negative selection	5871383
48772970	48772993	3	+	27260156	A375	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.30641824409493323	[340]	[410,639,498,443]	4	hSpCas9	negative selection	5871384
48773058	48773081	3	-	27260156	COLO741	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	-0.07489460866683556	[383]	[469,533,397]	-2	hSpCas9	negative selection	5928375
48773031	48773054	3	-	27260156	COLO741	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.3647136216010569	[1195]	[2012,1916,1971]	7	hSpCas9	negative selection	5928376
48783019	48783042	3	-	27260156	COLO741	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	0.13415333691567932	[898]	[1221,1407,1153]	3	hSpCas9	negative selection	5928377
48783054	48783077	3	-	27260156	COLO741	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.21526712745788018	[584]	[849,856,890]	4	hSpCas9	negative selection	5992633
48790585	48790608	3	-	27260156	COLO741	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	0.04097156713036365	[723]	[936,826,1077]	0	hSpCas9	negative selection	5992634
48772970	48772993	3	+	27260156	COLO741	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.2950311240747827	[340]	[547,651,412]	6	hSpCas9	negative selection	5992635
48773058	48773081	3	-	27260156	CAL120	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	-0.4446359271618864	[383]	[296,506,242]	-6	hSpCas9	negative selection	6049626
48773031	48773054	3	-	27260156	CAL120	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.3557397751330995	[1195]	[2157,1644,1946]	5	hSpCas9	negative selection	6049627
48783019	48783042	3	-	27260156	CAL120	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.3658485817243823	[898]	[1101,824,714]	-5	hSpCas9	negative selection	6049628
48783054	48783077	3	-	27260156	CAL120	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.08281332209975467	[584]	[982,673,688]	1	hSpCas9	negative selection	6113884
48790585	48790608	3	-	27260156	CAL120	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.5887606657469211	[723]	[756,539,524]	-7	hSpCas9	negative selection	6113885
48772970	48772993	3	+	27260156	CAL120	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	-0.41416089594238154	[340]	[226,426,287]	-5	hSpCas9	negative selection	6113886
48773058	48773081	3	-	27260156	CADOES1	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	0.03268389459331633	[383]	[452,368,301,335]	0	hSpCas9	negative selection	6170877
48773031	48773054	3	-	27260156	CADOES1	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.43665987272433116	[1195]	[1739,1444,1239,1599]	7	hSpCas9	negative selection	6170878
48783019	48783042	3	-	27260156	CADOES1	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.050103593558911586	[898]	[739,810,909,767]	-1	hSpCas9	negative selection	6170879
48783054	48783077	3	-	27260156	CADOES1	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.24952877516231914	[584]	[666,668,534,718]	4	hSpCas9	negative selection	6235135
48790585	48790608	3	-	27260156	CADOES1	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.1551023446863729	[723]	[689,396,502,836]	-3	hSpCas9	negative selection	6235136
48772970	48772993	3	+	27260156	CADOES1	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.19146249303233015	[340]	[430,409,234,372]	3	hSpCas9	negative selection	6235137
48773058	48773081	3	-	27260156	EWS502	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	0.10469249749827098	[383]	[426,411,416,497]	1	hSpCas9	negative selection	6292128
48773031	48773054	3	-	27260156	EWS502	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.42669615920151127	[1195]	[1710,1474,1954,1672]	7	hSpCas9	negative selection	6292129
48783019	48783042	3	-	27260156	EWS502	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	0.08110368471424723	[898]	[852,1011,1317,853]	1	hSpCas9	negative selection	6292130
48783054	48783077	3	-	27260156	EWS502	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.29517563078904835	[584]	[504,674,766,1153]	5	hSpCas9	negative selection	6356386
48790585	48790608	3	-	27260156	EWS502	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	0.028692861172783912	[723]	[624,878,664,984]	0	hSpCas9	negative selection	6356387
48772970	48772993	3	+	27260156	EWS502	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.5422306147765312	[340]	[491,471,625,518]	8	hSpCas9	negative selection	6356388
48773058	48773081	3	-	27260156	EW8	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	0.14315393265001244	[383]	[503,210,299,382]	2	hSpCas9	negative selection	6413379
48773031	48773054	3	-	27260156	EW8	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.4186796750573767	[1195]	[1333,1133,1233,1489]	7	hSpCas9	negative selection	6413380
48783019	48783042	3	-	27260156	EW8	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.03146278927964963	[898]	[810,838,606,621]	0	hSpCas9	negative selection	6413381
48783054	48783077	3	-	27260156	EW8	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.29057235489708716	[584]	[610,605,576,527]	5	hSpCas9	negative selection	6477637
48790585	48790608	3	-	27260156	EW8	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.3934994989484313	[723]	[594,284,427,495]	-6	hSpCas9	negative selection	6477638
48772970	48772993	3	+	27260156	EW8	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.28000397728078197	[340]	[514,263,154,456]	5	hSpCas9	negative selection	6477639
48773058	48773081	3	-	27260156	CORL105	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	0.15293903050054905	[383]	[474,483,559,488]	3	hSpCas9	negative selection	6534630
48773031	48773054	3	-	27260156	CORL105	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.24572819303292004	[1195]	[1767,1574,2063,1302]	4	hSpCas9	negative selection	6534631
48783019	48783042	3	-	27260156	CORL105	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	0.24928468664869063	[898]	[1154,1397,1510,974]	4	hSpCas9	negative selection	6534632
48783054	48783077	3	-	27260156	CORL105	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.4331903726324627	[584]	[1129,910,939,727]	7	hSpCas9	negative selection	6598888
48790585	48790608	3	-	27260156	CORL105	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.094617108150573	[723]	[668,676,1069,799]	-2	hSpCas9	negative selection	6598889
48772970	48772993	3	+	27260156	CORL105	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.23140914663105056	[340]	[504,454,611,326]	4	hSpCas9	negative selection	6598890
48773058	48773081	3	-	27260156	HS294T	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	0.005895917002489537	[383]	[221,91,125,150]	0	hSpCas9	negative selection	6655881
48773031	48773054	3	-	27260156	HS294T	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	-0.21408022484139	[1195]	[326,466,424,374]	-3	hSpCas9	negative selection	6655882
48783019	48783042	3	-	27260156	HS294T	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.4139739924339464	[898]	[203,248,307,292]	-5	hSpCas9	negative selection	6655883
48783054	48783077	3	-	27260156	HS294T	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.1451769699949887	[584]	[256,264,203,276]	2	hSpCas9	negative selection	6720139
48790585	48790608	3	-	27260156	HS294T	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.7868562546512256	[723]	[125,189,137,203]	-8	hSpCas9	negative selection	6720140
48772970	48772993	3	+	27260156	HS294T	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.5247951841993146	[340]	[295,135,175,131]	7	hSpCas9	negative selection	6720141
48773058	48773081	3	-	27260156	HCC44	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	0.06626332850609615	[383]	[519,241,531,566]	1	hSpCas9	negative selection	6777132
48773031	48773054	3	-	27260156	HCC44	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.3509694734410449	[1195]	[1749,1708,1580,1822]	6	hSpCas9	negative selection	6777133
48783019	48783042	3	-	27260156	HCC44	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.12569965848490372	[898]	[1081,928,1068,685]	-2	hSpCas9	negative selection	6777134
48783054	48783077	3	-	27260156	HCC44	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.34702574070590825	[584]	[966,735,957,747]	5	hSpCas9	negative selection	6841390
48790585	48790608	3	-	27260156	HCC44	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.1567268069987917	[723]	[1015,415,859,732]	-3	hSpCas9	negative selection	6841391
48772970	48772993	3	+	27260156	HCC44	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.05314686360681725	[340]	[236,460,684,244]	0	hSpCas9	negative selection	6841392
48773058	48773081	3	-	27260156	G402	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	-0.3273777300084736	[383]	[222,694,340,236]	-4	hSpCas9	negative selection	6898383
48773031	48773054	3	-	27260156	G402	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.2682210594203882	[1195]	[1942,1454,1547,2070]	3	hSpCas9	negative selection	6898384
48783019	48783042	3	-	27260156	G402	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.6799175702257931	[898]	[764,737,691,561]	-7	hSpCas9	negative selection	6898385
48783054	48783077	3	-	27260156	G402	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.47547456002034144	[584]	[1247,874,1068,812]	6	hSpCas9	negative selection	6962641
48790585	48790608	3	-	27260156	G402	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.18254355407791645	[723]	[1011,1080,565,515]	-2	hSpCas9	negative selection	6962642
48772970	48772993	3	+	27260156	G402	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.2385967084907835	[340]	[505,642,294,526]	3	hSpCas9	negative selection	6962643
48773058	48773081	3	-	27260156	L33	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	0.2803167179997921	[383]	[452,215,260,469]	6	hSpCas9	negative selection	7019634
48773031	48773054	3	-	27260156	L33	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	-0.21091229226032215	[1195]	[1020,367,800,941]	-5	hSpCas9	negative selection	7019635
48783019	48783042	3	-	27260156	L33	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.20654409753057978	[898]	[795,283,525,789]	-5	hSpCas9	negative selection	7019636
48783054	48783077	3	-	27260156	L33	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.13098699048539192	[584]	[644,266,454,542]	3	hSpCas9	negative selection	7083892
48790585	48790608	3	-	27260156	L33	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.2876677499559546	[723]	[468,240,403,674]	-6	hSpCas9	negative selection	7083893
48772970	48772993	3	+	27260156	L33	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.1383581544393802	[340]	[291,146,295,381]	3	hSpCas9	negative selection	7083894
48773058	48773081	3	-	27260156	K562	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	0.2778610841567736	[383]	[518,435,417,300]	3	hSpCas9	negative selection	7140885
48773031	48773054	3	-	27260156	K562	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.23358179052907335	[1195]	[1384,1454,1284,921]	3	hSpCas9	negative selection	7140886
48783019	48783042	3	-	27260156	K562	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	0.17109403304504212	[898]	[739,615,1727,521]	2	hSpCas9	negative selection	7140887
48783054	48783077	3	-	27260156	K562	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.5057000483704441	[584]	[572,847,971,564]	6	hSpCas9	negative selection	7205143
48790585	48790608	3	-	27260156	K562	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	0.09481616424955963	[723]	[751,406,1062,528]	1	hSpCas9	negative selection	7205144
48772970	48772993	3	+	27260156	K562	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.27506846814061003	[340]	[269,565,312,321]	3	hSpCas9	negative selection	7205145
48773058	48773081	3	-	27260156	HT29	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	-0.02525274603010813	[383]	[515,379,661,291]	0	hSpCas9	negative selection	7262136
48773031	48773054	3	-	27260156	HT29	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.32314224119966006	[1195]	[1857,2034,1950,1481]	6	hSpCas9	negative selection	7262137
48783019	48783042	3	-	27260156	HT29	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	0.3007638732654929	[898]	[1476,1394,1412,1130]	6	hSpCas9	negative selection	7262138
48783054	48783077	3	-	27260156	HT29	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.352858754985721	[584]	[1005,1039,870,747]	7	hSpCas9	negative selection	7326394
48790585	48790608	3	-	27260156	HT29	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	0.11988781859161568	[723]	[1008,1104,932,806]	2	hSpCas9	negative selection	7326395
48772970	48772993	3	+	27260156	HT29	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.4591745962988833	[340]	[683,510,495,585]	8	hSpCas9	negative selection	7326396
48773058	48773081	3	-	27260156	MHHES1	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	0.13738700082679425	[383]	[486,661,398,384]	2	hSpCas9	negative selection	7383387
48773031	48773054	3	-	27260156	MHHES1	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.16680760047038867	[1195]	[1631,1718,1762,1046]	3	hSpCas9	negative selection	7383388
48783019	48783042	3	-	27260156	MHHES1	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.021048887727175614	[898]	[1179,1056,1085,735]	0	hSpCas9	negative selection	7383389
48783054	48783077	3	-	27260156	MHHES1	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.4847414994739208	[584]	[1234,897,685,888]	8	hSpCas9	negative selection	7447645
48790585	48790608	3	-	27260156	MHHES1	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	0.10795799064183731	[723]	[826,1308,663,758]	2	hSpCas9	negative selection	7447646
48772970	48772993	3	+	27260156	MHHES1	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.5092079420061412	[340]	[537,884,508,326]	8	hSpCas9	negative selection	7447647
48773058	48773081	3	-	27260156	MEWO	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	-0.04641376315067247	[383]	[400,318,333]	-1	hSpCas9	negative selection	7504638
48773031	48773054	3	-	27260156	MEWO	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.24074965906348722	[1195]	[1595,1152,1270]	5	hSpCas9	negative selection	7504639
48783019	48783042	3	-	27260156	MEWO	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	0.12619042450823725	[898]	[972,776,1014]	3	hSpCas9	negative selection	7504640
48783054	48783077	3	-	27260156	MEWO	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	-0.0786911776475756	[584]	[735,481,378]	-2	hSpCas9	negative selection	7568896
48790585	48790608	3	-	27260156	MEWO	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.27108636689363724	[723]	[660,587,453]	-5	hSpCas9	negative selection	7568897
48772970	48772993	3	+	27260156	MEWO	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.1040957272174734	[340]	[404,269,365]	2	hSpCas9	negative selection	7568898
48773058	48773081	3	-	27260156	LNCAPCLONEFGC	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	-0.20788059022557298	[383]	[311,232,268,389]	-3	hSpCas9	negative selection	7625889
48773031	48773054	3	-	27260156	LNCAPCLONEFGC	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.46131882035144534	[1195]	[1440,1439,1707,1412]	7	hSpCas9	negative selection	7625890
48783019	48783042	3	-	27260156	LNCAPCLONEFGC	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.06420504714123776	[898]	[810,726,812,771]	-1	hSpCas9	negative selection	7625891
48783054	48783077	3	-	27260156	LNCAPCLONEFGC	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.3565377458594073	[584]	[629,935,695,437]	5	hSpCas9	negative selection	7690147
48790585	48790608	3	-	27260156	LNCAPCLONEFGC	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.12873139566977265	[723]	[423,563,735,700]	-2	hSpCas9	negative selection	7690148
48772970	48772993	3	+	27260156	LNCAPCLONEFGC	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.1932865036824456	[340]	[343,429,355,277]	3	hSpCas9	negative selection	7690149
48773058	48773081	3	-	27260156	PANC0327	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	-0.1291533158733807	[383]	[333,160,438,334]	-2	hSpCas9	negative selection	7747140
48773031	48773054	3	-	27260156	PANC0327	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.24650435373913093	[1195]	[1270,1078,1565,1149]	3	hSpCas9	negative selection	7747141
48783019	48783042	3	-	27260156	PANC0327	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.2883868344723609	[898]	[787,535,820,496]	-4	hSpCas9	negative selection	7747142
48783054	48783077	3	-	27260156	PANC0327	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.45964841491385594	[584]	[444,792,708,878]	6	hSpCas9	negative selection	7811398
48790585	48790608	3	-	27260156	PANC0327	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.12579543501695467	[723]	[644,678,738,287]	-2	hSpCas9	negative selection	7811399
48772970	48772993	3	+	27260156	PANC0327	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.39777886471721563	[340]	[322,406,439,418]	6	hSpCas9	negative selection	7811400
48773058	48773081	3	-	27260156	NCIH2009	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	-0.4562848632967256	[383]	[434,398,346]	-5	hSpCas9	negative selection	7868391
48773031	48773054	3	-	27260156	NCIH2009	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	-0.03446462691504126	[1195]	[1909,1847,1184]	0	hSpCas9	negative selection	7868392
48783019	48783042	3	-	27260156	NCIH2009	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.06922078409224075	[898]	[1355,1194,1069]	-1	hSpCas9	negative selection	7868393
48783054	48783077	3	-	27260156	NCIH2009	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.6407728008099027	[584]	[1207,1483,1111]	8	hSpCas9	negative selection	7932649
48790585	48790608	3	-	27260156	NCIH2009	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.3350464592023826	[723]	[1007,586,853]	-4	hSpCas9	negative selection	7932650
48772970	48772993	3	+	27260156	NCIH2009	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.4102163084988943	[340]	[723,646,544]	5	hSpCas9	negative selection	7932651
48773058	48773081	3	-	27260156	NCIH1373	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	0.18134180794410232	[383]	[671,405,384,138]	1	hSpCas9	negative selection	7989642
48773031	48773054	3	-	27260156	NCIH1373	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.47695068671041607	[1195]	[2350,1328,1807,555]	5	hSpCas9	negative selection	7989643
48783019	48783042	3	-	27260156	NCIH1373	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.252028228727202	[898]	[873,787,756,257]	-3	hSpCas9	negative selection	7989644
48783054	48783077	3	-	27260156	NCIH1373	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.8875324119967487	[584]	[816,1242,1356,359]	8	hSpCas9	negative selection	8053900
48790585	48790608	3	-	27260156	NCIH1373	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.49459723220379304	[723]	[836,180,776,153]	-5	hSpCas9	negative selection	8053901
48772970	48772993	3	+	27260156	NCIH1373	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	-0.024953781187269153	[340]	[466,344,333,97]	0	hSpCas9	negative selection	8053902
48773058	48773081	3	-	27260156	PATU8902	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	-0.049097358883884445	[383]	[451,689,411,540]	0	hSpCas9	negative selection	8110893
48773031	48773054	3	-	27260156	PATU8902	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.7242059564286702	[1195]	[3375,2358,2227,3201]	7	hSpCas9	negative selection	8110894
48783019	48783042	3	-	27260156	PATU8902	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.18528670454144913	[898]	[1264,801,1073,1279]	-2	hSpCas9	negative selection	8110895
48783054	48783077	3	-	27260156	PATU8902	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.8936513683238425	[584]	[1680,1870,1112,1475]	8	hSpCas9	negative selection	8175151
48790585	48790608	3	-	27260156	PATU8902	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.11314423179020516	[723]	[960,617,715,1555]	-1	hSpCas9	negative selection	8175152
48772970	48772993	3	+	27260156	PATU8902	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.6061409022484024	[340]	[947,883,582,474]	6	hSpCas9	negative selection	8175153
48773058	48773081	3	-	27260156	PANC1	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	-0.23508877552851704	[383]	[248,383,265,244]	-4	hSpCas9	negative selection	8232144
48773031	48773054	3	-	27260156	PANC1	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.33934578055346165	[1195]	[1214,1487,1282,1240]	5	hSpCas9	negative selection	8232145
48783019	48783042	3	-	27260156	PANC1	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.22274336491868285	[898]	[493,942,547,703]	-4	hSpCas9	negative selection	8232146
48783054	48783077	3	-	27260156	PANC1	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.36789709502663376	[584]	[545,719,698,636]	6	hSpCas9	negative selection	8296402
48790585	48790608	3	-	27260156	PANC1	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.3285398604481212	[723]	[392,593,577,439]	-5	hSpCas9	negative selection	8296403
48772970	48772993	3	+	27260156	PANC1	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.5411990949866099	[340]	[480,429,460,339]	8	hSpCas9	negative selection	8296404
48773058	48773081	3	-	27260156	PANC0813	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	-0.1298536311232199	[383]	[611,379,432,250]	-2	hSpCas9	negative selection	8353395
48773031	48773054	3	-	27260156	PANC0813	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.0034757662315580973	[1195]	[1614,1526,1196,1314]	0	hSpCas9	negative selection	8353396
48783019	48783042	3	-	27260156	PANC0813	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.22830864695466002	[898]	[776,839,1029,943]	-4	hSpCas9	negative selection	8353397
48783054	48783077	3	-	27260156	PANC0813	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.4121304560356947	[584]	[956,1037,868,801]	6	hSpCas9	negative selection	8417653
48790585	48790608	3	-	27260156	PANC0813	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.5000436518043498	[723]	[926,441,499,566]	-6	hSpCas9	negative selection	8417654
48772970	48772993	3	+	27260156	PANC0813	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.29376546773770645	[340]	[676,435,531,343]	5	hSpCas9	negative selection	8417655
48773058	48773081	3	-	27260156	RDES	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	-0.06700046218353067	[383]	[405,271,431,609]	-1	hSpCas9	negative selection	8474646
48773031	48773054	3	-	27260156	RDES	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.46011235303267695	[1195]	[1416,1587,2165,2593]	7	hSpCas9	negative selection	8474647
48783019	48783042	3	-	27260156	RDES	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.014751223387350798	[898]	[796,915,1194,1256]	0	hSpCas9	negative selection	8474648
48783054	48783077	3	-	27260156	RDES	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.4288610464617864	[584]	[593,1025,831,1250]	7	hSpCas9	negative selection	8538904
48790585	48790608	3	-	27260156	RDES	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.08222628018857114	[723]	[664,724,839,950]	-1	hSpCas9	negative selection	8538905
48772970	48772993	3	+	27260156	RDES	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.40696763801206315	[340]	[475,502,481,627]	6	hSpCas9	negative selection	8538906
48773058	48773081	3	-	27260156	PC3	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	0.2888317817042446	[383]	[211,446,942,535]	6	hSpCas9	negative selection	8595897
48773031	48773054	3	-	27260156	PC3	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.2630041850292908	[1195]	[905,1351,2422,1525]	6	hSpCas9	negative selection	8595898
48783019	48783042	3	-	27260156	PC3	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	0.055983568700281316	[898]	[549,1003,1789,786]	1	hSpCas9	negative selection	8595899
48783054	48783077	3	-	27260156	PC3	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.2095372825579292	[584]	[376,771,1139,652]	4	hSpCas9	negative selection	8660155
48790585	48790608	3	-	27260156	PC3	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.11623610423280861	[723]	[453,513,1278,688]	-3	hSpCas9	negative selection	8660156
48772970	48772993	3	+	27260156	PC3	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.07599120291116401	[340]	[340,385,400,271]	1	hSpCas9	negative selection	8660157
48773058	48773081	3	-	27260156	PATU8988T	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	0.23056720534017452	[383]	[490,400,327,526]	4	hSpCas9	negative selection	8717148
48773031	48773054	3	-	27260156	PATU8988T	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.3669362307985442	[1195]	[1531,1574,1420,1437]	6	hSpCas9	negative selection	8717149
48783019	48783042	3	-	27260156	PATU8988T	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.14679057784678895	[898]	[740,653,641,1117]	-3	hSpCas9	negative selection	8717150
48783054	48783077	3	-	27260156	PATU8988T	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.26700095535835006	[584]	[830,545,607,727]	4	hSpCas9	negative selection	8781406
48790585	48790608	3	-	27260156	PATU8988T	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	0.4141881424210705	[723]	[720,1164,781,1097]	7	hSpCas9	negative selection	8781407
48772970	48772993	3	+	27260156	PATU8988T	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.2573983593090929	[340]	[262,356,630,310]	4	hSpCas9	negative selection	8781408
48773058	48773081	3	-	27260156	T47D	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	-0.05299962777625944	[383]	[522,363,397,446]	-1	hSpCas9	negative selection	8838399
48773031	48773054	3	-	27260156	T47D	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.3138960877965937	[1195]	[1843,1458,1664,1992]	6	hSpCas9	negative selection	8838400
48783019	48783042	3	-	27260156	T47D	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	0.010616780454220431	[898]	[1150,931,1120,1024]	0	hSpCas9	negative selection	8838401
48783054	48783077	3	-	27260156	T47D	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.2746430288447707	[584]	[819,751,792,942]	6	hSpCas9	negative selection	8902657
48790585	48790608	3	-	27260156	T47D	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	0.010645984509041972	[723]	[1063,703,834,807]	0	hSpCas9	negative selection	8902658
48772970	48772993	3	+	27260156	T47D	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.4417344721091319	[340]	[556,494,520,590]	8	hSpCas9	negative selection	8902659
48773058	48773081	3	-	27260156	SU8686	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	-0.0369504049838717	[383]	[314,390,355,432]	0	hSpCas9	negative selection	8959650
48773031	48773054	3	-	27260156	SU8686	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.0024106240799144363	[1195]	[1015,1011,1234,1587]	0	hSpCas9	negative selection	8959651
48783019	48783042	3	-	27260156	SU8686	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.11463599141095304	[898]	[735,653,807,1177]	-2	hSpCas9	negative selection	8959652
48783054	48783077	3	-	27260156	SU8686	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.2905390934460284	[584]	[720,597,735,806]	5	hSpCas9	negative selection	9023908
48790585	48790608	3	-	27260156	SU8686	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.29825497607620477	[723]	[473,511,683,704]	-5	hSpCas9	negative selection	9023909
48772970	48772993	3	+	27260156	SU8686	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.2746770673162007	[340]	[358,338,503,455]	4	hSpCas9	negative selection	9023910
48773058	48773081	3	-	27260156	SKES1	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	-0.09667250864761595	[383]	[335,402,295,392]	-2	hSpCas9	negative selection	9080901
48773031	48773054	3	-	27260156	SKES1	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.31488618907865695	[1195]	[1713,1485,1433,1336]	6	hSpCas9	negative selection	9080902
48783019	48783042	3	-	27260156	SKES1	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	0.12165610980461716	[898]	[1082,998,971,868]	2	hSpCas9	negative selection	9080903
48783054	48783077	3	-	27260156	SKES1	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.10900273706287306	[584]	[751,732,543,524]	2	hSpCas9	negative selection	9145159
48790585	48790608	3	-	27260156	SKES1	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	0.15455913698136958	[723]	[733,938,1065,506]	3	hSpCas9	negative selection	9145160
48772970	48772993	3	+	27260156	SKES1	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.06820001030231926	[340]	[384,383,256,399]	1	hSpCas9	negative selection	9145161
48773058	48773081	3	-	27260156	TOV112D	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	-0.004459378274814574	[383]	[423,502,405,236]	0	hSpCas9	negative selection	9202152
48773031	48773054	3	-	27260156	TOV112D	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.1619355228049597	[1195]	[1183,1422,1251,1501]	3	hSpCas9	negative selection	9202153
48783019	48783042	3	-	27260156	TOV112D	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	0.13556853622760112	[898]	[684,1808,685,951]	2	hSpCas9	negative selection	9202154
48783054	48783077	3	-	27260156	TOV112D	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	-0.08364126545988215	[584]	[543,755,481,479]	-2	hSpCas9	negative selection	9266410
48790585	48790608	3	-	27260156	TOV112D	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	0.012826389286967665	[723]	[627,855,728,733]	0	hSpCas9	negative selection	9266411
48772970	48772993	3	+	27260156	TOV112D	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.33618386991257043	[340]	[235,500,496,488]	6	hSpCas9	negative selection	9266412
48773058	48773081	3	-	27260156	TC71	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	-0.005962120016092143	[383]	[431,325,401,483]	0	hSpCas9	negative selection	9323403
48773031	48773054	3	-	27260156	TC71	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.16936715170832084	[1195]	[1372,1378,1521,1494]	4	hSpCas9	negative selection	9323404
48783019	48783042	3	-	27260156	TC71	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.07462629977803781	[898]	[903,776,828,1168]	-2	hSpCas9	negative selection	9323405
48783054	48783077	3	-	27260156	TC71	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.27807050120573	[584]	[732,706,694,918]	6	hSpCas9	negative selection	9387661
48790585	48790608	3	-	27260156	TC71	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	-0.05219074961830383	[723]	[702,777,679,841]	-1	hSpCas9	negative selection	9387662
48772970	48772993	3	+	27260156	TC71	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.4717742335639605	[340]	[401,620,571,427]	9	hSpCas9	negative selection	9387663
48773058	48773081	3	-	27260156	TC32	viability	GATAATCAAACCCGCTCTGTTGG	PRKAR2A	ENSG00000114302	-0.2991608583411014	[383]	[312,171,426,311]	-5	hSpCas9	negative selection	9444654
48773031	48773054	3	-	27260156	TC32	viability	TATGACAACCGTGGCAGTTTTGG	PRKAR2A	ENSG00000114302	0.3734362760107277	[1195]	[1482,1152,1716,1541]	6	hSpCas9	negative selection	9444655
48783019	48783042	3	-	27260156	TC32	viability	GATGAGCATGTCATTGACCAAGG	PRKAR2A	ENSG00000114302	-0.08339156382244028	[898]	[771,617,912,936]	-1	hSpCas9	negative selection	9444656
48783054	48783077	3	-	27260156	TC32	viability	TTCTCGATGCCATGTTTGAAAGG	PRKAR2A	ENSG00000114302	0.2596991573269411	[584]	[594,577,792,688]	4	hSpCas9	negative selection	9508912
48790585	48790608	3	-	27260156	TC32	viability	TGAACAGAGATGCAGACTTCAGG	PRKAR2A	ENSG00000114302	0.061235830032115635	[723]	[602,638,918,710]	1	hSpCas9	negative selection	9508913
48772970	48772993	3	+	27260156	TC32	viability	GCCTTCTGAGGTAGCAACAATGG	PRKAR2A	ENSG00000114302	0.36587227304342523	[340]	[360,350,528,436]	6	hSpCas9	negative selection	9508914
48751660	48751683	3	-	27869803	HPAFII	viability after 27 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	-0.103664381983674	[627]	[333,284,NaN]	-1	hSpCas9	negative selection	9585220
48752215	48752238	3	+	27869803	HPAFII	viability after 27 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	1.2054422778871365	[219]	[269,263,NaN]	8	hSpCas9	negative selection	9585221
48772971	48772994	3	-	27869803	HPAFII	viability after 27 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	0.4827363719614526	[122]	[67,108,NaN]	4	hSpCas9	negative selection	9585222
48794014	48794037	3	-	27869803	HPAFII	viability after 27 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	0.8407030036957367	[405]	[258,484,NaN]	6	hSpCas9	negative selection	9585223
48847368	48847391	3	-	27869803	HPAFII	viability after 27 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	0.15659649361526373	[761]	[475,421,NaN]	1	hSpCas9	negative selection	9585224
48847369	48847392	3	-	27869803	HPAFII	viability after 27 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	0.3363009898634186	[540]	[291,414,NaN]	2	hSpCas9	negative selection	9585225
48751660	48751683	3	-	27869803	HPAFII	viability after 15 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	-0.08733211899247828	[627]	[839,507,NaN]	-1	hSpCas9	negative selection	9667669
48752215	48752238	3	+	27869803	HPAFII	viability after 15 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	0.9655982722555893	[219]	[515,427,NaN]	9	hSpCas9	negative selection	9667670
48772971	48772994	3	-	27869803	HPAFII	viability after 15 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	0.5277068829853448	[122]	[250,152,NaN]	6	hSpCas9	negative selection	9667671
48794014	48794037	3	-	27869803	HPAFII	viability after 15 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	0.1824996527424113	[405]	[636,406,NaN]	2	hSpCas9	negative selection	9667672
48847368	48847391	3	-	27869803	HPAFII	viability after 15 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	0.1455600731209561	[761]	[1429,579,NaN]	1	hSpCas9	negative selection	9667673
48847369	48847392	3	-	27869803	HPAFII	viability after 15 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	0.07933303668883895	[540]	[580,634,NaN]	0	hSpCas9	negative selection	9667674
48751660	48751683	3	-	27869803	ASPC1	viability after 36 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	-0.15680931534979947	[1368]	[215,675,376]	-2	hSpCas9	negative selection	9750118
48752215	48752238	3	+	27869803	ASPC1	viability after 36 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	0.45310307544256123	[695]	[269,445,282]	4	hSpCas9	negative selection	9750119
48772971	48772994	3	-	27869803	ASPC1	viability after 36 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	0.5196109819854292	[460]	[230,163,280]	5	hSpCas9	negative selection	9750120
48794014	48794037	3	-	27869803	ASPC1	viability after 36 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	0.4503500867785236	[986]	[228,920,277]	4	hSpCas9	negative selection	9750121
48847368	48847391	3	-	27869803	ASPC1	viability after 36 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	0.5132387217947976	[1661]	[1283,815,508]	5	hSpCas9	negative selection	9750122
48847369	48847392	3	-	27869803	ASPC1	viability after 36 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	-0.6872005496567767	[1150]	[227,275,240]	-6	hSpCas9	negative selection	9750123
48751660	48751683	3	-	27869803	PATU8988S	viability after 35 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	-0.11349321155926073	[1070]	[272,524,NaN]	-1	hSpCas9	negative selection	9832567
48752215	48752238	3	+	27869803	PATU8988S	viability after 35 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	0.21895648480186303	[672]	[303,326,NaN]	2	hSpCas9	negative selection	9832568
48772971	48772994	3	-	27869803	PATU8988S	viability after 35 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	0.11049107059684177	[367]	[163,155,NaN]	1	hSpCas9	negative selection	9832569
48794014	48794037	3	-	27869803	PATU8988S	viability after 35 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	0.5396995918161485	[820]	[553,406,NaN]	6	hSpCas9	negative selection	9832570
48847368	48847391	3	-	27869803	PATU8988S	viability after 35 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	0.48802591967530917	[1453]	[959,681,NaN]	5	hSpCas9	negative selection	9832571
48847369	48847392	3	-	27869803	PATU8988S	viability after 35 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	1.100735236051031	[834]	[823,617,NaN]	9	hSpCas9	negative selection	9832572
48751660	48751683	3	-	27869803	PATU8988S	viability after 31 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	0.2659799321158939	[1070]	[282,806,NaN]	3	hSpCas9	negative selection	9915016
48752215	48752238	3	+	27869803	PATU8988S	viability after 31 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	0.38270143719288074	[672]	[326,378,NaN]	5	hSpCas9	negative selection	9915017
48772971	48772994	3	-	27869803	PATU8988S	viability after 31 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	-0.1380048038653766	[367]	[91,185,NaN]	-1	hSpCas9	negative selection	9915018
48794014	48794037	3	-	27869803	PATU8988S	viability after 31 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	0.02166675359300041	[820]	[341,319,NaN]	0	hSpCas9	negative selection	9915019
48847368	48847391	3	-	27869803	PATU8988S	viability after 31 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	0.3899687773304732	[1453]	[537,1041,NaN]	5	hSpCas9	negative selection	9915020
48847369	48847392	3	-	27869803	PATU8988S	viability after 31 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	0.9722999216405855	[834]	[643,664,NaN]	9	hSpCas9	negative selection	9915021
48751660	48751683	3	-	27869803	HPAFII	viability after 35 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	-0.026691401245502178	[627]	[265,363,NaN]	0	hSpCas9	negative selection	9997465
48752215	48752238	3	+	27869803	HPAFII	viability after 35 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	1.7847554946120319	[219]	[355,414,NaN]	9	hSpCas9	negative selection	9997466
48772971	48772994	3	-	27869803	HPAFII	viability after 35 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	0.5063094851077248	[122]	[39,142,NaN]	3	hSpCas9	negative selection	9997467
48794014	48794037	3	-	27869803	HPAFII	viability after 35 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	1.2060852479507584	[405]	[389,568,NaN]	7	hSpCas9	negative selection	9997468
48847368	48847391	3	-	27869803	HPAFII	viability after 35 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	-0.04808353595108339	[761]	[247,513,NaN]	0	hSpCas9	negative selection	9997469
48847369	48847392	3	-	27869803	HPAFII	viability after 35 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	0.8337266650729915	[540]	[275,726,NaN]	5	hSpCas9	negative selection	9997470
48751660	48751683	3	-	27869803	HPAFII	viability after 31 days	CCTGCATGGACATCATGAAGAGG	PRKAR2A	ENSG00000114302	-0.03921482698489198	[627]	[353,330,NaN]	0	hSpCas9	negative selection	10079914
48752215	48752238	3	+	27869803	HPAFII	viability after 31 days	CTCTGGGTTTGTTGGTGACCAGG	PRKAR2A	ENSG00000114302	1.5495497216332248	[219]	[381,338,NaN]	9	hSpCas9	negative selection	10079915
48772971	48772994	3	-	27869803	HPAFII	viability after 31 days	ACCATTGTTGCTACCTCAGAAGG	PRKAR2A	ENSG00000114302	0.9031220609784232	[122]	[52,211,NaN]	6	hSpCas9	negative selection	10079916
48794014	48794037	3	-	27869803	HPAFII	viability after 31 days	CTATAACCCTGATGAGGAAGAGG	PRKAR2A	ENSG00000114302	0.8483194478047703	[405]	[325,501,NaN]	6	hSpCas9	negative selection	10079917
48847368	48847391	3	-	27869803	HPAFII	viability after 31 days	CCGTGTCGCCGACGCCAAAGGGG	PRKAR2A	ENSG00000114302	-0.18114476232578536	[761]	[291,469,NaN]	-1	hSpCas9	negative selection	10079918
48847369	48847392	3	-	27869803	HPAFII	viability after 31 days	ACCGTGTCGCCGACGCCAAAGGG	PRKAR2A	ENSG00000114302	0.6494616982291268	[540]	[358,603,NaN]	5	hSpCas9	negative selection	10079919
48847334	48847357	3	-	28162770	P31FUJ	viability	GAGGAGGACGAGGACTTGGAAGG	PRKAR2A	ENSG00000114302	-5.40272720585669	[71]	[1]	-9	hSpCas9	negative selection	10217030
48847539	48847562	3	-	28162770	P31FUJ	viability	GCTGCTGCAGGGCTACACGGTGG	PRKAR2A	ENSG00000114302	-0.48137855755448156	[138]	[116]	-4	hSpCas9	negative selection	10217031
48847494	48847517	3	-	28162770	P31FUJ	viability	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	-1.940621452921068	[48]	[14]	-8	hSpCas9	negative selection	10217032
48765023	48765046	3	-	28162770	P31FUJ	viability	GGAGAGAAGATCTATAAGGATGG	PRKAR2A	ENSG00000114302	-0.8361432344503892	[78]	[51]	-6	hSpCas9	negative selection	10217033
48847441	48847464	3	+	28162770	P31FUJ	viability	GGCGGGCAGGACTGAGGCTGGGG	PRKAR2A	ENSG00000114302	0.03467810645060726	[161]	[194]	0	hSpCas9	negative selection	10217034
48847353	48847376	3	-	28162770	P31FUJ	viability	CAAAGGGGACAGCGAGTCGGAGG	PRKAR2A	ENSG00000114302	0.6905765139827089	[260]	[494]	7	hSpCas9	negative selection	10217035
48793996	48794019	3	-	28162770	P31FUJ	viability	AGAGGAAGATACAGATCCAAGGG	PRKAR2A	ENSG00000114302	-0.25704975066105606	[119]	[117]	-2	hSpCas9	negative selection	10217036
48773040	48773063	3	-	28162770	P31FUJ	viability	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	0.954567931487343	[273]	[623]	9	hSpCas9	negative selection	10217037
48752284	48752307	3	-	28162770	P31FUJ	viability	CAAGGATGGTGGGAACCAGGAGG	PRKAR2A	ENSG00000114302	-0.35210113278672317	[62]	[57]	-3	hSpCas9	negative selection	10217038
48847334	48847357	3	-	28162770	TF1	viability	GAGGAGGACGAGGACTTGGAAGG	PRKAR2A	ENSG00000114302	NaN	[NaN]	[0]	1	hSpCas9	negative selection	10386396
48847539	48847562	3	-	28162770	TF1	viability	GCTGCTGCAGGGCTACACGGTGG	PRKAR2A	ENSG00000114302	NaN	[NaN]	[85]	1	hSpCas9	negative selection	10386397
48847494	48847517	3	-	28162770	TF1	viability	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	NaN	[NaN]	[43]	1	hSpCas9	negative selection	10386398
48765023	48765046	3	-	28162770	TF1	viability	GGAGAGAAGATCTATAAGGATGG	PRKAR2A	ENSG00000114302	NaN	[NaN]	[5]	1	hSpCas9	negative selection	10386399
48847441	48847464	3	+	28162770	TF1	viability	GGCGGGCAGGACTGAGGCTGGGG	PRKAR2A	ENSG00000114302	NaN	[NaN]	[95]	1	hSpCas9	negative selection	10386400
48847353	48847376	3	-	28162770	TF1	viability	CAAAGGGGACAGCGAGTCGGAGG	PRKAR2A	ENSG00000114302	NaN	[NaN]	[316]	1	hSpCas9	negative selection	10386401
48793996	48794019	3	-	28162770	TF1	viability	AGAGGAAGATACAGATCCAAGGG	PRKAR2A	ENSG00000114302	NaN	[NaN]	[0]	1	hSpCas9	negative selection	10386402
48773040	48773063	3	-	28162770	TF1	viability	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	NaN	[NaN]	[135]	1	hSpCas9	negative selection	10386403
48752284	48752307	3	-	28162770	TF1	viability	CAAGGATGGTGGGAACCAGGAGG	PRKAR2A	ENSG00000114302	NaN	[NaN]	[9]	1	hSpCas9	negative selection	10386404
48847334	48847357	3	-	28162770	SKM1	viability	GAGGAGGACGAGGACTTGGAAGG	PRKAR2A	ENSG00000114302	-2.2005133212757357	[12]	[4]	-8	hSpCas9	negative selection	10555762
48847539	48847562	3	-	28162770	SKM1	viability	GCTGCTGCAGGGCTACACGGTGG	PRKAR2A	ENSG00000114302	-0.42772275890995914	[34]	[45]	-4	hSpCas9	negative selection	10555763
48847494	48847517	3	-	28162770	SKM1	viability	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	0.663425129148236	[9]	[27]	6	hSpCas9	negative selection	10555764
48765023	48765046	3	-	28162770	SKM1	viability	GGAGAGAAGATCTATAAGGATGG	PRKAR2A	ENSG00000114302	-0.8220016980220055	[22]	[22]	-6	hSpCas9	negative selection	10555765
48847441	48847464	3	+	28162770	SKM1	viability	GGCGGGCAGGACTGAGGCTGGGG	PRKAR2A	ENSG00000114302	0.06552357271958183	[59]	[110]	0	hSpCas9	negative selection	10555766
48847353	48847376	3	-	28162770	SKM1	viability	CAAAGGGGACAGCGAGTCGGAGG	PRKAR2A	ENSG00000114302	-0.31420705782330915	[63]	[90]	-3	hSpCas9	negative selection	10555767
48793996	48794019	3	-	28162770	SKM1	viability	AGAGGAAGATACAGATCCAAGGG	PRKAR2A	ENSG00000114302	0.4190064014817896	[21]	[51]	4	hSpCas9	negative selection	10555768
48773040	48773063	3	-	28162770	SKM1	viability	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	0.12737222890802646	[86]	[167]	1	hSpCas9	negative selection	10555769
48752284	48752307	3	-	28162770	SKM1	viability	CAAGGATGGTGGGAACCAGGAGG	PRKAR2A	ENSG00000114302	1.2368919910315632	[5]	[24]	9	hSpCas9	negative selection	10555770
48847334	48847357	3	-	28162770	SKM1	viability	GAGGAGGACGAGGACTTGGAAGG	PRKAR2A	ENSG00000114302	-2.2005133212757357	[12]	[4]	-8	hSpCas9	negative selection	10725128
48847539	48847562	3	-	28162770	SKM1	viability	GCTGCTGCAGGGCTACACGGTGG	PRKAR2A	ENSG00000114302	-0.42772275890995914	[34]	[45]	-4	hSpCas9	negative selection	10725129
48847494	48847517	3	-	28162770	SKM1	viability	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	0.663425129148236	[9]	[27]	6	hSpCas9	negative selection	10725130
48765023	48765046	3	-	28162770	SKM1	viability	GGAGAGAAGATCTATAAGGATGG	PRKAR2A	ENSG00000114302	-0.8220016980220055	[22]	[22]	-6	hSpCas9	negative selection	10725131
48847441	48847464	3	+	28162770	SKM1	viability	GGCGGGCAGGACTGAGGCTGGGG	PRKAR2A	ENSG00000114302	0.06552357271958183	[59]	[110]	0	hSpCas9	negative selection	10725132
48847353	48847376	3	-	28162770	SKM1	viability	CAAAGGGGACAGCGAGTCGGAGG	PRKAR2A	ENSG00000114302	-0.31420705782330915	[63]	[90]	-3	hSpCas9	negative selection	10725133
48793996	48794019	3	-	28162770	SKM1	viability	AGAGGAAGATACAGATCCAAGGG	PRKAR2A	ENSG00000114302	0.4190064014817896	[21]	[51]	4	hSpCas9	negative selection	10725134
48773040	48773063	3	-	28162770	SKM1	viability	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	0.12737222890802646	[86]	[167]	1	hSpCas9	negative selection	10725135
48752284	48752307	3	-	28162770	SKM1	viability	CAAGGATGGTGGGAACCAGGAGG	PRKAR2A	ENSG00000114302	1.2368919910315632	[5]	[24]	9	hSpCas9	negative selection	10725136
48847334	48847357	3	-	28162770	PL21	viability	GAGGAGGACGAGGACTTGGAAGG	PRKAR2A	ENSG00000114302	-4.443716575285405	[49]	[0]	-9	hSpCas9	negative selection	10894494
48847539	48847562	3	-	28162770	PL21	viability	GCTGCTGCAGGGCTACACGGTGG	PRKAR2A	ENSG00000114302	-0.9814671920006276	[185]	[40]	-6	hSpCas9	negative selection	10894495
48847494	48847517	3	-	28162770	PL21	viability	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	1.2903374234608984	[30]	[32]	9	hSpCas9	negative selection	10894496
48765023	48765046	3	-	28162770	PL21	viability	GGAGAGAAGATCTATAAGGATGG	PRKAR2A	ENSG00000114302	0.41426441984216766	[99]	[57]	3	hSpCas9	negative selection	10894497
48847441	48847464	3	+	28162770	PL21	viability	GGCGGGCAGGACTGAGGCTGGGG	PRKAR2A	ENSG00000114302	0.7252306592330775	[163]	[117]	6	hSpCas9	negative selection	10894498
48847353	48847376	3	-	28162770	PL21	viability	CAAAGGGGACAGCGAGTCGGAGG	PRKAR2A	ENSG00000114302	-0.0699495488784242	[163]	[67]	0	hSpCas9	negative selection	10894499
48793996	48794019	3	-	28162770	PL21	viability	AGAGGAAGATACAGATCCAAGGG	PRKAR2A	ENSG00000114302	-1.2592920041479774	[98]	[17]	-7	hSpCas9	negative selection	10894500
48773040	48773063	3	-	28162770	PL21	viability	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	-0.35537910833935415	[193]	[65]	-3	hSpCas9	negative selection	10894501
48752284	48752307	3	-	28162770	PL21	viability	CAAGGATGGTGGGAACCAGGAGG	PRKAR2A	ENSG00000114302	-0.02225280684712816	[41]	[17]	0	hSpCas9	negative selection	10894502
48847334	48847357	3	-	28162770	P31FUJ	viability	GAGGAGGACGAGGACTTGGAAGG	PRKAR2A	ENSG00000114302	-5.40272720585669	[71]	[1]	-9	hSpCas9	negative selection	11063860
48847539	48847562	3	-	28162770	P31FUJ	viability	GCTGCTGCAGGGCTACACGGTGG	PRKAR2A	ENSG00000114302	-0.48137855755448156	[138]	[116]	-4	hSpCas9	negative selection	11063861
48847494	48847517	3	-	28162770	P31FUJ	viability	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	-1.940621452921068	[48]	[14]	-8	hSpCas9	negative selection	11063862
48765023	48765046	3	-	28162770	P31FUJ	viability	GGAGAGAAGATCTATAAGGATGG	PRKAR2A	ENSG00000114302	-0.8361432344503892	[78]	[51]	-6	hSpCas9	negative selection	11063863
48847441	48847464	3	+	28162770	P31FUJ	viability	GGCGGGCAGGACTGAGGCTGGGG	PRKAR2A	ENSG00000114302	0.03467810645060726	[161]	[194]	0	hSpCas9	negative selection	11063864
48847353	48847376	3	-	28162770	P31FUJ	viability	CAAAGGGGACAGCGAGTCGGAGG	PRKAR2A	ENSG00000114302	0.6905765139827089	[260]	[494]	7	hSpCas9	negative selection	11063865
48793996	48794019	3	-	28162770	P31FUJ	viability	AGAGGAAGATACAGATCCAAGGG	PRKAR2A	ENSG00000114302	-0.25704975066105606	[119]	[117]	-2	hSpCas9	negative selection	11063866
48773040	48773063	3	-	28162770	P31FUJ	viability	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	0.954567931487343	[273]	[623]	9	hSpCas9	negative selection	11063867
48752284	48752307	3	-	28162770	P31FUJ	viability	CAAGGATGGTGGGAACCAGGAGG	PRKAR2A	ENSG00000114302	-0.35210113278672317	[62]	[57]	-3	hSpCas9	negative selection	11063868
48847334	48847357	3	-	28162770	OCIAML5	viability	GAGGAGGACGAGGACTTGGAAGG	PRKAR2A	ENSG00000114302	-3.1739946657513594	[49]	[9]	-9	hSpCas9	negative selection	11233226
48847539	48847562	3	-	28162770	OCIAML5	viability	GCTGCTGCAGGGCTACACGGTGG	PRKAR2A	ENSG00000114302	-1.129600546392906	[79]	[65]	-6	hSpCas9	negative selection	11233227
48847494	48847517	3	-	28162770	OCIAML5	viability	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	-1.413945458472112	[30]	[20]	-7	hSpCas9	negative selection	11233228
48765023	48765046	3	-	28162770	OCIAML5	viability	GGAGAGAAGATCTATAAGGATGG	PRKAR2A	ENSG00000114302	-0.3545669113931802	[50]	[71]	-3	hSpCas9	negative selection	11233229
48847441	48847464	3	+	28162770	OCIAML5	viability	GGCGGGCAGGACTGAGGCTGGGG	PRKAR2A	ENSG00000114302	-1.1111537921811279	[72]	[60]	-6	hSpCas9	negative selection	11233230
48847353	48847376	3	-	28162770	OCIAML5	viability	CAAAGGGGACAGCGAGTCGGAGG	PRKAR2A	ENSG00000114302	0.018165554165673226	[185]	[339]	0	hSpCas9	negative selection	11233231
48793996	48794019	3	-	28162770	OCIAML5	viability	AGAGGAAGATACAGATCCAAGGG	PRKAR2A	ENSG00000114302	-0.16556604368077876	[63]	[102]	-1	hSpCas9	negative selection	11233232
48773040	48773063	3	-	28162770	OCIAML5	viability	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	0.6454330886068198	[135]	[383]	5	hSpCas9	negative selection	11233233
48752284	48752307	3	-	28162770	OCIAML5	viability	CAAGGATGGTGGGAACCAGGAGG	PRKAR2A	ENSG00000114302	0.22322155644024	[27]	[58]	1	hSpCas9	negative selection	11233234
48847334	48847357	3	-	28162770	EOL1	viability	GAGGAGGACGAGGACTTGGAAGG	PRKAR2A	ENSG00000114302	-4.09782004145792	[64]	[1]	-9	hSpCas9	negative selection	11402592
48847539	48847562	3	-	28162770	EOL1	viability	GCTGCTGCAGGGCTACACGGTGG	PRKAR2A	ENSG00000114302	0.794912491153939	[255]	[233]	7	hSpCas9	negative selection	11402593
48847494	48847517	3	-	28162770	EOL1	viability	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	-0.9558706126767929	[80]	[21]	-6	hSpCas9	negative selection	11402594
48765023	48765046	3	-	28162770	EOL1	viability	GGAGAGAAGATCTATAAGGATGG	PRKAR2A	ENSG00000114302	-0.544005237035311	[118]	[42]	-4	hSpCas9	negative selection	11402595
48847441	48847464	3	+	28162770	EOL1	viability	GGCGGGCAGGACTGAGGCTGGGG	PRKAR2A	ENSG00000114302	-0.7881702763489944	[294]	[89]	-5	hSpCas9	negative selection	11402596
48847353	48847376	3	-	28162770	EOL1	viability	CAAAGGGGACAGCGAGTCGGAGG	PRKAR2A	ENSG00000114302	1.891144613303321	[283]	[554]	9	hSpCas9	negative selection	11402597
48793996	48794019	3	-	28162770	EOL1	viability	AGAGGAAGATACAGATCCAAGGG	PRKAR2A	ENSG00000114302	-0.6367634610859763	[120]	[40]	-4	hSpCas9	negative selection	11402598
48773040	48773063	3	-	28162770	EOL1	viability	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	-0.09163215548489989	[268]	[132]	0	hSpCas9	negative selection	11402599
48752284	48752307	3	-	28162770	EOL1	viability	CAAGGATGGTGGGAACCAGGAGG	PRKAR2A	ENSG00000114302	-3.7758919465705576	[77]	[2]	-9	hSpCas9	negative selection	11402600
48847334	48847357	3	-	28162770	MOLM13	viability	GAGGAGGACGAGGACTTGGAAGG	PRKAR2A	ENSG00000114302	-3.064605699282442	[80]	[6]	-8	hSpCas9	negative selection	11571958
48847539	48847562	3	-	28162770	MOLM13	viability	GCTGCTGCAGGGCTACACGGTGG	PRKAR2A	ENSG00000114302	-0.03036148598324656	[225]	[159]	0	hSpCas9	negative selection	11571959
48847494	48847517	3	-	28162770	MOLM13	viability	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	1.1284029152729118	[61]	[97]	8	hSpCas9	negative selection	11571960
48765023	48765046	3	-	28162770	MOLM13	viability	GGAGAGAAGATCTATAAGGATGG	PRKAR2A	ENSG00000114302	1.5604555002806517	[82]	[176]	9	hSpCas9	negative selection	11571961
48847441	48847464	3	+	28162770	MOLM13	viability	GGCGGGCAGGACTGAGGCTGGGG	PRKAR2A	ENSG00000114302	-0.47789022745753457	[234]	[121]	-3	hSpCas9	negative selection	11571962
48847353	48847376	3	-	28162770	MOLM13	viability	CAAAGGGGACAGCGAGTCGGAGG	PRKAR2A	ENSG00000114302	1.3828078806548108	[226]	[427]	9	hSpCas9	negative selection	11571963
48793996	48794019	3	-	28162770	MOLM13	viability	AGAGGAAGATACAGATCCAAGGG	PRKAR2A	ENSG00000114302	-0.7364691169616073	[105]	[45]	-4	hSpCas9	negative selection	11571964
48773040	48773063	3	-	28162770	MOLM13	viability	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	0.3405850572695005	[295]	[270]	2	hSpCas9	negative selection	11571965
48752284	48752307	3	-	28162770	MOLM13	viability	CAAGGATGGTGGGAACCAGGAGG	PRKAR2A	ENSG00000114302	-0.055672574512434014	[22]	[15]	0	hSpCas9	negative selection	11571966
48847334	48847357	3	-	28162770	HEL	viability	GAGGAGGACGAGGACTTGGAAGG	PRKAR2A	ENSG00000114302	-5.311457478386518	[61]	[0]	-9	hSpCas9	negative selection	11741324
48847539	48847562	3	-	28162770	HEL	viability	GCTGCTGCAGGGCTACACGGTGG	PRKAR2A	ENSG00000114302	0.2046177196084719	[209]	[154]	1	hSpCas9	negative selection	11741325
48847494	48847517	3	-	28162770	HEL	viability	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	-0.11062120041651768	[58]	[34]	-1	hSpCas9	negative selection	11741326
48765023	48765046	3	-	28162770	HEL	viability	GGAGAGAAGATCTATAAGGATGG	PRKAR2A	ENSG00000114302	-0.19551009800303087	[117]	[65]	-1	hSpCas9	negative selection	11741327
48847441	48847464	3	+	28162770	HEL	viability	GGCGGGCAGGACTGAGGCTGGGG	PRKAR2A	ENSG00000114302	0.6052641265816942	[194]	[189]	5	hSpCas9	negative selection	11741328
48847353	48847376	3	-	28162770	HEL	viability	CAAAGGGGACAGCGAGTCGGAGG	PRKAR2A	ENSG00000114302	-0.30573086735956095	[219]	[113]	-2	hSpCas9	negative selection	11741329
48793996	48794019	3	-	28162770	HEL	viability	AGAGGAAGATACAGATCCAAGGG	PRKAR2A	ENSG00000114302	0.09959650697382783	[101]	[69]	0	hSpCas9	negative selection	11741330
48773040	48773063	3	-	28162770	HEL	viability	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	-0.7231326104746021	[249]	[96]	-5	hSpCas9	negative selection	11741331
48752284	48752307	3	-	28162770	HEL	viability	CAAGGATGGTGGGAACCAGGAGG	PRKAR2A	ENSG00000114302	0.5272616145804214	[38]	[35]	4	hSpCas9	negative selection	11741332
48847334	48847357	3	-	28162770	MV411	viability	GAGGAGGACGAGGACTTGGAAGG	PRKAR2A	ENSG00000114302	-5.585452463381966	[56]	[0]	-9	hSpCas9	negative selection	11910690
48847539	48847562	3	-	28162770	MV411	viability	GCTGCTGCAGGGCTACACGGTGG	PRKAR2A	ENSG00000114302	-1.3375249499383808	[131]	[43]	-7	hSpCas9	negative selection	11910691
48847494	48847517	3	-	28162770	MV411	viability	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	-1.8278505765214617	[58]	[13]	-8	hSpCas9	negative selection	11910692
48765023	48765046	3	-	28162770	MV411	viability	GGAGAGAAGATCTATAAGGATGG	PRKAR2A	ENSG00000114302	-0.6116999133773751	[77]	[42]	-4	hSpCas9	negative selection	11910693
48847441	48847464	3	+	28162770	MV411	viability	GGCGGGCAGGACTGAGGCTGGGG	PRKAR2A	ENSG00000114302	-2.1276018805641495	[165]	[31]	-8	hSpCas9	negative selection	11910694
48847353	48847376	3	-	28162770	MV411	viability	CAAAGGGGACAGCGAGTCGGAGG	PRKAR2A	ENSG00000114302	0.7282771084573654	[224]	[313]	6	hSpCas9	negative selection	11910695
48793996	48794019	3	-	28162770	MV411	viability	AGAGGAAGATACAGATCCAAGGG	PRKAR2A	ENSG00000114302	-1.3899923698325163	[55]	[17]	-7	hSpCas9	negative selection	11910696
48773040	48773063	3	-	28162770	MV411	viability	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	-0.20002142618844598	[239]	[175]	-1	hSpCas9	negative selection	11910697
48752284	48752307	3	-	28162770	MV411	viability	CAAGGATGGTGGGAACCAGGAGG	PRKAR2A	ENSG00000114302	-0.10048575263753134	[41]	[32]	-1	hSpCas9	negative selection	11910698
48847334	48847357	3	-	28162770	MONOMAC1	viability	GAGGAGGACGAGGACTTGGAAGG	PRKAR2A	ENSG00000114302	-2.897476565200646	[25]	[3]	-9	hSpCas9	negative selection	12080056
48847539	48847562	3	-	28162770	MONOMAC1	viability	GCTGCTGCAGGGCTACACGGTGG	PRKAR2A	ENSG00000114302	-0.05548270284553436	[96]	[106]	0	hSpCas9	negative selection	12080057
48847494	48847517	3	-	28162770	MONOMAC1	viability	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	-0.1248870613037183	[38]	[40]	-1	hSpCas9	negative selection	12080058
48765023	48765046	3	-	28162770	MONOMAC1	viability	GGAGAGAAGATCTATAAGGATGG	PRKAR2A	ENSG00000114302	-0.37760909270137444	[50]	[44]	-3	hSpCas9	negative selection	12080059
48847441	48847464	3	+	28162770	MONOMAC1	viability	GGCGGGCAGGACTGAGGCTGGGG	PRKAR2A	ENSG00000114302	0.5321092426473533	[110]	[183]	5	hSpCas9	negative selection	12080060
48847353	48847376	3	-	28162770	MONOMAC1	viability	CAAAGGGGACAGCGAGTCGGAGG	PRKAR2A	ENSG00000114302	-0.1385411977494092	[144]	[150]	-1	hSpCas9	negative selection	12080061
48793996	48794019	3	-	28162770	MONOMAC1	viability	AGAGGAAGATACAGATCCAAGGG	PRKAR2A	ENSG00000114302	0.01977454201359441	[36]	[42]	0	hSpCas9	negative selection	12080062
48773040	48773063	3	-	28162770	MONOMAC1	viability	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	0.8210347258624643	[118]	[240]	7	hSpCas9	negative selection	12080063
48752284	48752307	3	-	28162770	MONOMAC1	viability	CAAGGATGGTGGGAACCAGGAGG	PRKAR2A	ENSG00000114302	0.3004628124112627	[16]	[23]	3	hSpCas9	negative selection	12080064
48847334	48847357	3	-	28162770	OCIAML2	viability	GAGGAGGACGAGGACTTGGAAGG	PRKAR2A	ENSG00000114302	-3.7925579201295236	[4]	[1]	-9	hSpCas9	negative selection	12249422
48847539	48847562	3	-	28162770	OCIAML2	viability	GCTGCTGCAGGGCTACACGGTGG	PRKAR2A	ENSG00000114302	-1.725886880484236	[36]	[61]	-8	hSpCas9	negative selection	12249423
48847494	48847517	3	-	28162770	OCIAML2	viability	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	-1.6341285575250408	[13]	[24]	-7	hSpCas9	negative selection	12249424
48765023	48765046	3	-	28162770	OCIAML2	viability	GGAGAGAAGATCTATAAGGATGG	PRKAR2A	ENSG00000114302	-1.1130778206240775	[15]	[40]	-6	hSpCas9	negative selection	12249425
48847441	48847464	3	+	28162770	OCIAML2	viability	GGCGGGCAGGACTGAGGCTGGGG	PRKAR2A	ENSG00000114302	-0.663274903184557	[35]	[125]	-5	hSpCas9	negative selection	12249426
48847353	48847376	3	-	28162770	OCIAML2	viability	CAAAGGGGACAGCGAGTCGGAGG	PRKAR2A	ENSG00000114302	-0.2884264940214122	[38]	[176]	-2	hSpCas9	negative selection	12249427
48793996	48794019	3	-	28162770	OCIAML2	viability	AGAGGAAGATACAGATCCAAGGG	PRKAR2A	ENSG00000114302	1.6655068627438676	[11]	[210]	9	hSpCas9	negative selection	12249428
48773040	48773063	3	-	28162770	OCIAML2	viability	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	0.0047081843044967375	[40]	[227]	0	hSpCas9	negative selection	12249429
48752284	48752307	3	-	28162770	OCIAML2	viability	CAAGGATGGTGGGAACCAGGAGG	PRKAR2A	ENSG00000114302	1.8147723936200872	[1]	[38]	9	hSpCas9	negative selection	12249430
48847334	48847357	3	-	28162770	OCIAML3	viability	GAGGAGGACGAGGACTTGGAAGG	PRKAR2A	ENSG00000114302	-1.3183731977107358	[18]	[22]	-7	hSpCas9	negative selection	12418788
48847539	48847562	3	-	28162770	OCIAML3	viability	GCTGCTGCAGGGCTACACGGTGG	PRKAR2A	ENSG00000114302	-0.13832815654797337	[34]	[95]	-1	hSpCas9	negative selection	12418789
48847494	48847517	3	-	28162770	OCIAML3	viability	TGACCTCGTCGAATTCGCAGTGG	PRKAR2A	ENSG00000114302	-0.5433815672541953	[13]	[28]	-4	hSpCas9	negative selection	12418790
48765023	48765046	3	-	28162770	OCIAML3	viability	GGAGAGAAGATCTATAAGGATGG	PRKAR2A	ENSG00000114302	-0.5433815672541953	[13]	[28]	-4	hSpCas9	negative selection	12418791
48847441	48847464	3	+	28162770	OCIAML3	viability	GGCGGGCAGGACTGAGGCTGGGG	PRKAR2A	ENSG00000114302	0.7404113987463959	[45]	[231]	6	hSpCas9	negative selection	12418792
48847353	48847376	3	-	28162770	OCIAML3	viability	CAAAGGGGACAGCGAGTCGGAGG	PRKAR2A	ENSG00000114302	1.133912814239036	[47]	[317]	8	hSpCas9	negative selection	12418793
48793996	48794019	3	-	28162770	OCIAML3	viability	AGAGGAAGATACAGATCCAAGGG	PRKAR2A	ENSG00000114302	0.6010083420809796	[18]	[86]	5	hSpCas9	negative selection	12418794
48773040	48773063	3	-	28162770	OCIAML3	viability	GTTGGTCAATATGACAACCGTGG	PRKAR2A	ENSG00000114302	0.5569342577505763	[67]	[301]	5	hSpCas9	negative selection	12418795
48752284	48752307	3	-	28162770	OCIAML3	viability	CAAGGATGGTGGGAACCAGGAGG	PRKAR2A	ENSG00000114302	0.2133472817334412	[11]	[41]	2	hSpCas9	negative selection	12418796