| 107044907 | 107044930 | 7 | + | 26472758 | Jiyoye | viability | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 0.42047220411933117 | [107] | [108] | 3 | hSpCas9 | negative selection | 127382 | 107146336 | 107146359 | 7 | + | 26472758 | Jiyoye | viability | GATGGTGTTGGAAGATGTGTTGG | PRKAR2B | ENSG00000005249 | 0.17136244440710424 | [503] | [427] | 1 | hSpCas9 | negative selection | 127383 | 107044940 | 107044963 | 7 | + | 26472758 | Jiyoye | viability | GCTGCTGCAGGGCTTCACGGTGG | PRKAR2B | ENSG00000005249 | 0.1977220158769235 | [73] | [63] | 1 | hSpCas9 | negative selection | 127384 | 107045153 | 107045176 | 7 | + | 26472758 | Jiyoye | viability | GTCCGACTCCGAGGACGGGGAGG | PRKAR2B | ENSG00000005249 | -1.1085244567781691 | [182] | [63] | -6 | hSpCas9 | negative selection | 127385 | 107044964 | 107044987 | 7 | + | 26472758 | Jiyoye | viability | GGTGCTGAGGCACCAGCCCGCGG | PRKAR2B | ENSG00000005249 | 0.7994928042846334 | [15] | [20] | 5 | hSpCas9 | negative selection | 127386 | 107140907 | 107140930 | 7 | + | 26472758 | Jiyoye | viability | GTAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | 0.9723746274055995 | [97] | [144] | 6 | hSpCas9 | negative selection | 127387 | 107153210 | 107153233 | 7 | + | 26472758 | Jiyoye | viability | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | 0.4524993720153638 | [93] | [96] | 3 | hSpCas9 | negative selection | 127388 | 107157296 | 107157319 | 7 | - | 26472758 | Jiyoye | viability | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -0.8558590243279205 | [119] | [49] | -6 | hSpCas9 | negative selection | 127389 | 107044922 | 107044945 | 7 | - | 26472758 | Jiyoye | viability | GCAGCTCCGTCAGTCCCGCCGGG | PRKAR2B | ENSG00000005249 | -1.8558590243279205 | [119] | [24] | -8 | hSpCas9 | negative selection | 127390 | 107044980 | 107045003 | 7 | - | 26472758 | Jiyoye | viability | GCGAACTCCAGCAGGTCCGCGGG | PRKAR2B | ENSG00000005249 | 0.9307373375628862 | [63] | [91] | 6 | hSpCas9 | negative selection | 127391 | 107044907 | 107044930 | 7 | + | 26472758 | KBM7 | viability | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 0.3384015627872725 | [321,269] | [198,153] | 3 | hSpCas9 | negative selection | 318500 | 107146336 | 107146359 | 7 | + | 26472758 | KBM7 | viability | GATGGTGTTGGAAGATGTGTTGG | PRKAR2B | ENSG00000005249 | 0.5457574912867007 | [1812,1925] | [1087,1476] | 6 | hSpCas9 | negative selection | 318501 | 107044940 | 107044963 | 7 | + | 26472758 | KBM7 | viability | GCTGCTGCAGGGCTTCACGGTGG | PRKAR2B | ENSG00000005249 | 0.33271805341339306 | [425,185] | [319,44] | 3 | hSpCas9 | negative selection | 318502 | 107045153 | 107045176 | 7 | + | 26472758 | KBM7 | viability | GTCCGACTCCGAGGACGGGGAGG | PRKAR2B | ENSG00000005249 | 1.2634674342424068 | [193,94] | [97,211] | 9 | hSpCas9 | negative selection | 318503 | 107044964 | 107044987 | 7 | + | 26472758 | KBM7 | viability | GGTGCTGAGGCACCAGCCCGCGG | PRKAR2B | ENSG00000005249 | 0.7378545588832239 | [127,32] | [113,10] | 7 | hSpCas9 | negative selection | 318504 | 107140907 | 107140930 | 7 | + | 26472758 | KBM7 | viability | GTAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | -0.15910453337736663 | [990,781] | [292,439] | -1 | hSpCas9 | negative selection | 318505 | 107153210 | 107153233 | 7 | + | 26472758 | KBM7 | viability | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -0.42481196705467983 | [376,492] | [113,191] | -4 | hSpCas9 | negative selection | 318506 | 107157296 | 107157319 | 7 | - | 26472758 | KBM7 | viability | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | 0.7538248440267751 | [322,185] | [315,90] | 8 | hSpCas9 | negative selection | 318507 | 107044922 | 107044945 | 7 | - | 26472758 | KBM7 | viability | GCAGCTCCGTCAGTCCCGCCGGG | PRKAR2B | ENSG00000005249 | 0.2938260527858484 | [494,192] | [164,212] | 3 | hSpCas9 | negative selection | 318508 | 107044980 | 107045003 | 7 | - | 26472758 | KBM7 | viability | GCGAACTCCAGCAGGTCCGCGGG | PRKAR2B | ENSG00000005249 | 0.4430678453155816 | [440,468] | [355,236] | 5 | hSpCas9 | negative selection | 318509 | 107044907 | 107044930 | 7 | + | 26472758 | Raji | viability | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 1.0402693395150626 | [87] | [41] | 8 | hSpCas9 | negative selection | 509618 | 107146336 | 107146359 | 7 | + | 26472758 | Raji | viability | GATGGTGTTGGAAGATGTGTTGG | PRKAR2B | ENSG00000005249 | 0.20088238369804112 | [925] | [246] | 2 | hSpCas9 | negative selection | 509619 | 107044940 | 107044963 | 7 | + | 26472758 | Raji | viability | GCTGCTGCAGGGCTTCACGGTGG | PRKAR2B | ENSG00000005249 | 0.28141293514864874 | [77] | [21] | 2 | hSpCas9 | negative selection | 509620 | 107045153 | 107045176 | 7 | + | 26472758 | Raji | viability | GTCCGACTCCGAGGACGGGGAGG | PRKAR2B | ENSG00000005249 | 0.37041794120739346 | [129] | [38] | 3 | hSpCas9 | negative selection | 509621 | 107044964 | 107044987 | 7 | + | 26472758 | Raji | viability | GGTGCTGAGGCACCAGCCCGCGG | PRKAR2B | ENSG00000005249 | -0.35204808326369763 | [43] | [7] | -3 | hSpCas9 | negative selection | 509622 | 107140907 | 107140930 | 7 | + | 26472758 | Raji | viability | GTAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | 0.08220497237760288 | [288] | [70] | 0 | hSpCas9 | negative selection | 509623 | 107153210 | 107153233 | 7 | + | 26472758 | Raji | viability | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | 0.7550817914427181 | [119] | [46] | 7 | hSpCas9 | negative selection | 509624 | 107157296 | 107157319 | 7 | - | 26472758 | Raji | viability | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | 0.8104017976164679 | [85] | [34] | 7 | hSpCas9 | negative selection | 509625 | 107044922 | 107044945 | 7 | - | 26472758 | Raji | viability | GCAGCTCCGTCAGTCCCGCCGGG | PRKAR2B | ENSG00000005249 | -1.9045891062924767 | [241] | [14] | -8 | hSpCas9 | negative selection | 509626 | 107044980 | 107045003 | 7 | - | 26472758 | Raji | viability | GCGAACTCCAGCAGGTCCGCGGG | PRKAR2B | ENSG00000005249 | 0.11966186515203621 | [233] | [58] | 1 | hSpCas9 | negative selection | 509627 | 107044907 | 107044930 | 7 | + | 26472758 | K562 | viability | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 0.30307294538725743 | [240] | [250] | 2 | hSpCas9 | negative selection | 700736 | 107146336 | 107146359 | 7 | + | 26472758 | K562 | viability | GATGGTGTTGGAAGATGTGTTGG | PRKAR2B | ENSG00000005249 | 0.6329034492806427 | [1740] | [2278] | 5 | hSpCas9 | negative selection | 700737 | 107044940 | 107044963 | 7 | + | 26472758 | K562 | viability | GCTGCTGCAGGGCTTCACGGTGG | PRKAR2B | ENSG00000005249 | 0.3053009698134692 | [115] | [120] | 2 | hSpCas9 | negative selection | 700738 | 107045153 | 107045176 | 7 | + | 26472758 | K562 | viability | GTCCGACTCCGAGGACGGGGAGG | PRKAR2B | ENSG00000005249 | -0.7555812723335531 | [187] | [93] | -4 | hSpCas9 | negative selection | 700739 | 107044964 | 107044987 | 7 | + | 26472758 | K562 | viability | GGTGCTGAGGCACCAGCCCGCGG | PRKAR2B | ENSG00000005249 | 0.8147344524232016 | [32] | [48] | 6 | hSpCas9 | negative selection | 700740 | 107140907 | 107140930 | 7 | + | 26472758 | K562 | viability | GTAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | -0.4012978041338056 | [678] | [433] | -3 | hSpCas9 | negative selection | 700741 | 107153210 | 107153233 | 7 | + | 26472758 | K562 | viability | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -0.1531736371529877 | [273] | [207] | -1 | hSpCas9 | negative selection | 700742 | 107157296 | 107157319 | 7 | - | 26472758 | K562 | viability | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -0.6323098974318193 | [212] | [115] | -4 | hSpCas9 | negative selection | 700743 | 107044922 | 107044945 | 7 | - | 26472758 | K562 | viability | GCAGCTCCGTCAGTCCCGCCGGG | PRKAR2B | ENSG00000005249 | 0.35376612385480777 | [126] | [136] | 2 | hSpCas9 | negative selection | 700744 | 107044980 | 107045003 | 7 | - | 26472758 | K562 | viability | GCGAACTCCAGCAGGTCCGCGGG | PRKAR2B | ENSG00000005249 | 0.6931303159956189 | [306] | [418] | 6 | hSpCas9 | negative selection | 700745 | 107044907 | 107044930 | 7 | + | 26627737 | DLD1 | viability | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -0.8715918730736352 | [125] | [15,4,39] | -7 | hSpCas9 | negative selection | 834436 | 107045149 | 107045172 | 7 | + | 26627737 | DLD1 | viability | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | -0.10254143847553365 | [1274] | [396,271,430] | -1 | hSpCas9 | negative selection | 834437 | 107146371 | 107146394 | 7 | + | 26627737 | DLD1 | viability | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | 0.8114399450504066 | [563] | [211,406,312] | 7 | hSpCas9 | negative selection | 834438 | 107150905 | 107150928 | 7 | + | 26627737 | DLD1 | viability | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | -0.03575190270721729 | [748] | [163,282,238] | 0 | hSpCas9 | negative selection | 834439 | 107153210 | 107153233 | 7 | + | 26627737 | DLD1 | viability | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -0.3667554146661536 | [257] | [67,42,73] | -4 | hSpCas9 | negative selection | 834440 | 107157296 | 107157319 | 7 | - | 26627737 | DLD1 | viability | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -0.7522780811577596 | [782] | [109,178,147] | -6 | hSpCas9 | negative selection | 834441 | 107044907 | 107044930 | 7 | + | 26627737 | GBM cells | viability after 5 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -0.24693699157776905 | [51] | [15,30] | -4 | hSpCas9 | negative selection | 916751 | 107045149 | 107045172 | 7 | + | 26627737 | GBM cells | viability after 5 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | 0.5097550074324473 | [441] | [350,323] | 7 | hSpCas9 | negative selection | 916752 | 107146371 | 107146394 | 7 | + | 26627737 | GBM cells | viability after 5 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | 0.0936255554460198 | [435] | [229,268] | 1 | hSpCas9 | negative selection | 916753 | 107150905 | 107150928 | 7 | + | 26627737 | GBM cells | viability after 5 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | 0.186994199289375 | [275] | [159,176] | 3 | hSpCas9 | negative selection | 916754 | 107153210 | 107153233 | 7 | + | 26627737 | GBM cells | viability after 5 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -1.1010861251143145 | [165] | [35,46] | -9 | hSpCas9 | negative selection | 916755 | 107157296 | 107157319 | 7 | - | 26627737 | GBM cells | viability after 5 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -0.48186079987661334 | [318] | [112,131] | -6 | hSpCas9 | negative selection | 916756 | 107044907 | 107044930 | 7 | + | 26627737 | GBM cells | viability after 13 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 0.337672102583346 | [51] | [33,36] | 4 | hSpCas9 | negative selection | 999066 | 107045149 | 107045172 | 7 | + | 26627737 | GBM cells | viability after 13 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | 0.2923566765760002 | [441] | [371,229] | 4 | hSpCas9 | negative selection | 999067 | 107146371 | 107146394 | 7 | + | 26627737 | GBM cells | viability after 13 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | 0.20857869370161086 | [435] | [231,306] | 2 | hSpCas9 | negative selection | 999068 | 107150905 | 107150928 | 7 | + | 26627737 | GBM cells | viability after 13 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | 0.1743953321798103 | [275] | [152,181] | 2 | hSpCas9 | negative selection | 999069 | 107153210 | 107153233 | 7 | + | 26627737 | GBM cells | viability after 13 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -0.7980151578218176 | [165] | [69,36] | -7 | hSpCas9 | negative selection | 999070 | 107157296 | 107157319 | 7 | - | 26627737 | GBM cells | viability after 13 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -1.197045261700596 | [318] | [96,57] | -8 | hSpCas9 | negative selection | 999071 | 107044907 | 107044930 | 7 | + | 26627737 | GBM cells | viability after 21 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -0.09349627866483745 | [51] | [26,25] | -1 | hSpCas9 | negative selection | 1081381 | 107045149 | 107045172 | 7 | + | 26627737 | GBM cells | viability after 21 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | 0.19188311153778037 | [441] | [290,258] | 2 | hSpCas9 | negative selection | 1081382 | 107146371 | 107146394 | 7 | + | 26627737 | GBM cells | viability after 21 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | 0.6126917109015376 | [435] | [380,344] | 6 | hSpCas9 | negative selection | 1081383 | 107150905 | 107150928 | 7 | + | 26627737 | GBM cells | viability after 21 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | 0.980458018784125 | [275] | [310,281] | 8 | hSpCas9 | negative selection | 1081384 | 107153210 | 107153233 | 7 | + | 26627737 | GBM cells | viability after 21 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -0.890602988879995 | [165] | [56,40] | -6 | hSpCas9 | negative selection | 1081385 | 107157296 | 107157319 | 7 | - | 26627737 | GBM cells | viability after 21 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -1.1462389117455327 | [318] | [82,73] | -7 | hSpCas9 | negative selection | 1081386 | 107044907 | 107044930 | 7 | + | 26627737 | RPE1 | viability after 9 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 6.316319422579489 | [2] | [90,53] | 9 | hSpCas9 | negative selection | 1163696 | 107045149 | 107045172 | 7 | + | 26627737 | RPE1 | viability after 9 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | 0.9804146005823786 | [1329] | [776,878] | 6 | hSpCas9 | negative selection | 1163697 | 107146371 | 107146394 | 7 | + | 26627737 | RPE1 | viability after 9 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | 0.13734963055828664 | [2494] | [859,857] | 1 | hSpCas9 | negative selection | 1163698 | 107150905 | 107150928 | 7 | + | 26627737 | RPE1 | viability after 9 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | 0.3488323308853092 | [1467] | [638,515] | 2 | hSpCas9 | negative selection | 1163699 | 107153210 | 107153233 | 7 | + | 26627737 | RPE1 | viability after 9 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | 0.8865305020951095 | [342] | [146,264] | 5 | hSpCas9 | negative selection | 1163700 | 107157296 | 107157319 | 7 | - | 26627737 | RPE1 | viability after 9 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -0.34597446850535407 | [947] | [143,348] | -2 | hSpCas9 | negative selection | 1163701 | 107044907 | 107044930 | 7 | + | 26627737 | RPE1 | viability after 12 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 5.902110152294581 | [2] | [71,22] | 9 | hSpCas9 | negative selection | 1246011 | 107045149 | 107045172 | 7 | + | 26627737 | RPE1 | viability after 12 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | 0.8546740321707946 | [1329] | [515,783] | 5 | hSpCas9 | negative selection | 1246012 | 107146371 | 107146394 | 7 | + | 26627737 | RPE1 | viability after 12 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | -0.12420306572187023 | [2494] | [632,595] | -1 | hSpCas9 | negative selection | 1246013 | 107150905 | 107150928 | 7 | + | 26627737 | RPE1 | viability after 12 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | 0.09845317631436212 | [1467] | [481,358] | 0 | hSpCas9 | negative selection | 1246014 | 107153210 | 107153233 | 7 | + | 26627737 | RPE1 | viability after 12 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | 0.48143439089720375 | [342] | [99,158] | 3 | hSpCas9 | negative selection | 1246015 | 107157296 | 107157319 | 7 | - | 26627737 | RPE1 | viability after 12 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -0.32851475568626853 | [947] | [162,244] | -2 | hSpCas9 | negative selection | 1246016 | 107044907 | 107044930 | 7 | + | 26627737 | RPE1 | viability after 15 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 6.222023020478998 | [2] | [99,27] | 9 | hSpCas9 | negative selection | 1328326 | 107045149 | 107045172 | 7 | + | 26627737 | RPE1 | viability after 15 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | 0.4354765244572336 | [1329] | [435,578] | 3 | hSpCas9 | negative selection | 1328327 | 107146371 | 107146394 | 7 | + | 26627737 | RPE1 | viability after 15 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | 0.027294700613849976 | [2494] | [788,651] | 0 | hSpCas9 | negative selection | 1328328 | 107150905 | 107150928 | 7 | + | 26627737 | RPE1 | viability after 15 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | 0.35011243026526984 | [1467] | [679,383] | 2 | hSpCas9 | negative selection | 1328329 | 107153210 | 107153233 | 7 | + | 26627737 | RPE1 | viability after 15 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | 1.2519276122384944 | [342] | [310,153] | 7 | hSpCas9 | negative selection | 1328330 | 107157296 | 107157319 | 7 | - | 26627737 | RPE1 | viability after 15 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | 0.40044519859785027 | [947] | [299,405] | 2 | hSpCas9 | negative selection | 1328331 | 107044907 | 107044930 | 7 | + | 26627737 | RPE1 | viability after 18 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 5.327599431732576 | [2] | [61,0] | 9 | hSpCas9 | negative selection | 1410641 | 107045149 | 107045172 | 7 | + | 26627737 | RPE1 | viability after 18 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | 0.8778990986455635 | [1329] | [676,640] | 5 | hSpCas9 | negative selection | 1410642 | 107146371 | 107146394 | 7 | + | 26627737 | RPE1 | viability after 18 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | -0.058654568349036706 | [2494] | [762,521] | 0 | hSpCas9 | negative selection | 1410643 | 107150905 | 107150928 | 7 | + | 26627737 | RPE1 | viability after 18 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | 0.2500216702855955 | [1467] | [678,248] | 1 | hSpCas9 | negative selection | 1410644 | 107153210 | 107153233 | 7 | + | 26627737 | RPE1 | viability after 18 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | 0.9650297027108398 | [342] | [200,158] | 6 | hSpCas9 | negative selection | 1410645 | 107157296 | 107157319 | 7 | - | 26627737 | RPE1 | viability after 18 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -0.34022052594343566 | [947] | [160,245] | -2 | hSpCas9 | negative selection | 1410646 | 107044907 | 107044930 | 7 | + | 26627737 | HeLa | viability after 8 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -0.6640990521449739 | [94] | [12,0,58] | -6 | hSpCas9 | negative selection | 1492956 | 107045149 | 107045172 | 7 | + | 26627737 | HeLa | viability after 8 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | 0.762381235498169 | [714] | [562,351,665] | 6 | hSpCas9 | negative selection | 1492957 | 107146371 | 107146394 | 7 | + | 26627737 | HeLa | viability after 8 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | 0.27850428754177137 | [763] | [497,498,244] | 2 | hSpCas9 | negative selection | 1492958 | 107150905 | 107150928 | 7 | + | 26627737 | HeLa | viability after 8 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | -0.5098761101477415 | [543] | [133,196,160] | -5 | hSpCas9 | negative selection | 1492959 | 107153210 | 107153233 | 7 | + | 26627737 | HeLa | viability after 8 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | 0.13373237359905044 | [238] | [209,62,91] | 1 | hSpCas9 | negative selection | 1492960 | 107157296 | 107157319 | 7 | - | 26627737 | HeLa | viability after 8 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -0.16983181513399281 | [431] | [201,65,235] | -2 | hSpCas9 | negative selection | 1492961 | 107044907 | 107044930 | 7 | + | 26627737 | HeLa | viability after 12 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -0.4557789508764549 | [94] | [0,0,85] | -4 | hSpCas9 | negative selection | 1575271 | 107045149 | 107045172 | 7 | + | 26627737 | HeLa | viability after 12 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | 0.10993289163553732 | [714] | [98,358,487] | 1 | hSpCas9 | negative selection | 1575272 | 107146371 | 107146394 | 7 | + | 26627737 | HeLa | viability after 12 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | 0.6638289985820636 | [763] | [319,654,503] | 5 | hSpCas9 | negative selection | 1575273 | 107150905 | 107150928 | 7 | + | 26627737 | HeLa | viability after 12 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | -0.31185584511014053 | [543] | [204,171,167] | -3 | hSpCas9 | negative selection | 1575274 | 107153210 | 107153233 | 7 | + | 26627737 | HeLa | viability after 12 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -1.4027353007382306 | [238] | [4,47,56] | -8 | hSpCas9 | negative selection | 1575275 | 107157296 | 107157319 | 7 | - | 26627737 | HeLa | viability after 12 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | 0.053445824206319686 | [431] | [187,136,235] | 0 | hSpCas9 | negative selection | 1575276 | 107044907 | 107044930 | 7 | + | 26627737 | HeLa | viability after 15 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -4.878800375321486 | [94] | [0,0,1] | -9 | hSpCas9 | negative selection | 1657586 | 107045149 | 107045172 | 7 | + | 26627737 | HeLa | viability after 15 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | 0.2821222103573665 | [714] | [257,439,365] | 2 | hSpCas9 | negative selection | 1657587 | 107146371 | 107146394 | 7 | + | 26627737 | HeLa | viability after 15 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | 0.40997557555929864 | [763] | [375,489,370] | 3 | hSpCas9 | negative selection | 1657588 | 107150905 | 107150928 | 7 | + | 26627737 | HeLa | viability after 15 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | -0.3087904156309531 | [543] | [205,223,99] | -3 | hSpCas9 | negative selection | 1657589 | 107153210 | 107153233 | 7 | + | 26627737 | HeLa | viability after 15 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -0.17608975753973632 | [238] | [95,102,56] | -1 | hSpCas9 | negative selection | 1657590 | 107157296 | 107157319 | 7 | - | 26627737 | HeLa | viability after 15 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -0.20098909254323866 | [431] | [120,141,199] | -2 | hSpCas9 | negative selection | 1657591 | 107044907 | 107044930 | 7 | + | 26627737 | HeLa | viability after 18 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -4.636972394680643 | [94] | [0,0,1] | -9 | hSpCas9 | negative selection | 1739901 | 107045149 | 107045172 | 7 | + | 26627737 | HeLa | viability after 18 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | 0.2909492837350497 | [714] | [171,370,365] | 2 | hSpCas9 | negative selection | 1739902 | 107146371 | 107146394 | 7 | + | 26627737 | HeLa | viability after 18 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | 0.4326441740929514 | [763] | [263,406,370] | 3 | hSpCas9 | negative selection | 1739903 | 107150905 | 107150928 | 7 | + | 26627737 | HeLa | viability after 18 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | -0.22499307662791823 | [543] | [152,192,99] | -2 | hSpCas9 | negative selection | 1739904 | 107153210 | 107153233 | 7 | + | 26627737 | HeLa | viability after 18 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -0.15083816908003078 | [238] | [65,86,56] | -1 | hSpCas9 | negative selection | 1739905 | 107157296 | 107157319 | 7 | - | 26627737 | HeLa | viability after 18 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -0.20026595282444953 | [431] | [84,112,199] | -2 | hSpCas9 | negative selection | 1739906 | 107044907 | 107044930 | 7 | + | 26627737 | HCT116 | viability after 6 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 0.5239469228265623 | [22] | [10,1] | 3 | hSpCas9 | negative selection | 1822216 | 107045149 | 107045172 | 7 | + | 26627737 | HCT116 | viability after 6 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | 0.15066920808709017 | [1299] | [494,78] | 0 | hSpCas9 | negative selection | 1822217 | 107146371 | 107146394 | 7 | + | 26627737 | HCT116 | viability after 6 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | 0.04060508438396482 | [1113] | [212,161] | 0 | hSpCas9 | negative selection | 1822218 | 107150905 | 107150928 | 7 | + | 26627737 | HCT116 | viability after 6 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | 0.47980537083525343 | [800] | [134,197] | 2 | hSpCas9 | negative selection | 1822219 | 107153210 | 107153233 | 7 | + | 26627737 | HCT116 | viability after 6 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | 0.6575196396463017 | [275] | [90,55] | 3 | hSpCas9 | negative selection | 1822220 | 107157296 | 107157319 | 7 | - | 26627737 | HCT116 | viability after 6 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -1.1002304156218985 | [503] | [25,42] | -6 | hSpCas9 | negative selection | 1822221 | 107044907 | 107044930 | 7 | + | 26627737 | HCT116 | viability after 8 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -0.8872311108646018 | [72] | [19,5,38] | -8 | hSpCas9 | negative selection | 1904531 | 107045149 | 107045172 | 7 | + | 26627737 | HCT116 | viability after 8 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | -0.6269924040315233 | [927] | [233,293,461] | -6 | hSpCas9 | negative selection | 1904532 | 107146371 | 107146394 | 7 | + | 26627737 | HCT116 | viability after 8 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | 0.3871658637613523 | [529] | [430,440,275] | 4 | hSpCas9 | negative selection | 1904533 | 107150905 | 107150928 | 7 | + | 26627737 | HCT116 | viability after 8 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | 0.9668400548598745 | [220] | [276,219,217] | 8 | hSpCas9 | negative selection | 1904534 | 107153210 | 107153233 | 7 | + | 26627737 | HCT116 | viability after 8 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -1.0789029936082333 | [376] | [98,94,100] | -8 | hSpCas9 | negative selection | 1904535 | 107157296 | 107157319 | 7 | - | 26627737 | HCT116 | viability after 8 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | 0.6702027405953006 | [188] | [179,198,118] | 6 | hSpCas9 | negative selection | 1904536 | 107044907 | 107044930 | 7 | + | 26627737 | HCT116 | viability after 9 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 2.818833167603754 | [22] | [1,75] | 9 | hSpCas9 | negative selection | 1986846 | 107045149 | 107045172 | 7 | + | 26627737 | HCT116 | viability after 9 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | -0.22836057518968944 | [1299] | [321,275] | -1 | hSpCas9 | negative selection | 1986847 | 107146371 | 107146394 | 7 | + | 26627737 | HCT116 | viability after 9 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | 0.0725613066733164 | [1113] | [452,201] | 0 | hSpCas9 | negative selection | 1986848 | 107150905 | 107150928 | 7 | + | 26627737 | HCT116 | viability after 9 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | 0.5982584421987006 | [800] | [134,472] | 4 | hSpCas9 | negative selection | 1986849 | 107153210 | 107153233 | 7 | + | 26627737 | HCT116 | viability after 9 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | 0.7422518769930934 | [275] | [277,0] | 5 | hSpCas9 | negative selection | 1986850 | 107157296 | 107157319 | 7 | - | 26627737 | HCT116 | viability after 9 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | 0.8997711677270873 | [503] | [130,345] | 6 | hSpCas9 | negative selection | 1986851 | 107044907 | 107044930 | 7 | + | 26627737 | HCT116 | viability after 12 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -2.025880120720685 | [72] | [11,7,7] | -9 | hSpCas9 | negative selection | 2069161 | 107045149 | 107045172 | 7 | + | 26627737 | HCT116 | viability after 12 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | -0.206968180742507 | [927] | [540,375,338] | -2 | hSpCas9 | negative selection | 2069162 | 107146371 | 107146394 | 7 | + | 26627737 | HCT116 | viability after 12 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | 0.3705364205082019 | [529] | [319,450,314] | 3 | hSpCas9 | negative selection | 2069163 | 107150905 | 107150928 | 7 | + | 26627737 | HCT116 | viability after 12 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | 0.9357614620728744 | [220] | [254,237,170] | 7 | hSpCas9 | negative selection | 2069164 | 107153210 | 107153233 | 7 | + | 26627737 | HCT116 | viability after 12 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -1.1615360562020827 | [376] | [116,79,65] | -8 | hSpCas9 | negative selection | 2069165 | 107157296 | 107157319 | 7 | - | 26627737 | HCT116 | viability after 12 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | 0.7974542210795491 | [188] | [173,140,201] | 7 | hSpCas9 | negative selection | 2069166 | 107044907 | 107044930 | 7 | + | 26627737 | HCT116 | viability after 15 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -0.8329126394208708 | [72] | [20,0,47] | -7 | hSpCas9 | negative selection | 2151476 | 107045149 | 107045172 | 7 | + | 26627737 | HCT116 | viability after 15 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | -0.5240431677720829 | [927] | [473,325,324] | -5 | hSpCas9 | negative selection | 2151477 | 107146371 | 107146394 | 7 | + | 26627737 | HCT116 | viability after 15 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | 0.22455590238114953 | [529] | [417,341,314] | 2 | hSpCas9 | negative selection | 2151478 | 107150905 | 107150928 | 7 | + | 26627737 | HCT116 | viability after 15 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | 1.1168881015897711 | [220] | [262,261,298] | 8 | hSpCas9 | negative selection | 2151479 | 107153210 | 107153233 | 7 | + | 26627737 | HCT116 | viability after 15 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -1.3192985350674895 | [376] | [157,110,0] | -8 | hSpCas9 | negative selection | 2151480 | 107157296 | 107157319 | 7 | - | 26627737 | HCT116 | viability after 15 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | 0.8295203762051842 | [188] | [223,127,229] | 7 | hSpCas9 | negative selection | 2151481 | 107044907 | 107044930 | 7 | + | 26627737 | HCT116 | viability after 18 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -1.3715750347314581 | [72] | [0,0,40] | -8 | hSpCas9 | negative selection | 2233791 | 107045149 | 107045172 | 7 | + | 26627737 | HCT116 | viability after 18 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | 0.2993439161641589 | [927] | [546,470,647] | 2 | hSpCas9 | negative selection | 2233792 | 107146371 | 107146394 | 7 | + | 26627737 | HCT116 | viability after 18 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | 0.387325661528383 | [529] | [376,312,315] | 3 | hSpCas9 | negative selection | 2233793 | 107150905 | 107150928 | 7 | + | 26627737 | HCT116 | viability after 18 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | 1.462877685717455 | [220] | [490,192,201] | 9 | hSpCas9 | negative selection | 2233794 | 107153210 | 107153233 | 7 | + | 26627737 | HCT116 | viability after 18 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -1.299452526029584 | [376] | [79,89,49] | -8 | hSpCas9 | negative selection | 2233795 | 107157296 | 107157319 | 7 | - | 26627737 | HCT116 | viability after 18 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | 0.7121449477000681 | [188] | [224,67,161] | 6 | hSpCas9 | negative selection | 2233796 | 107044904 | 107044927 | 7 | + | 24336569 | HL60 | viability | CAGGATGAGCATCGAGATCCCGG | PRKAR2B | ENSG00000005249 | -0.021605720773158588 | [896] | [1869] | 0 | hSpCas9 | negative selection | 2286392 | 107044916 | 107044939 | 7 | + | 24336569 | HL60 | viability | CGAGATCCCGGCGGGACTGACGG | PRKAR2B | ENSG00000005249 | 0.984009736848385 | [139] | [585] | 7 | hSpCas9 | negative selection | 2286393 | 107044922 | 107044945 | 7 | - | 24336569 | HL60 | viability | GCAGCTCCGTCAGTCCCGCCGGG | PRKAR2B | ENSG00000005249 | 4.27256483742549 | [39] | [1635] | 9 | hSpCas9 | negative selection | 2286394 | 107044928 | 107044951 | 7 | + | 24336569 | HL60 | viability | GGGACTGACGGAGCTGCTGCAGG | PRKAR2B | ENSG00000005249 | 0.41807907023549123 | [631] | [1786] | 4 | hSpCas9 | negative selection | 2286395 | 107044937 | 107044960 | 7 | + | 24336569 | HL60 | viability | GGAGCTGCTGCAGGGCTTCACGG | PRKAR2B | ENSG00000005249 | 0.8536184226897652 | [124] | [477] | 7 | hSpCas9 | negative selection | 2286396 | 107044964 | 107044987 | 7 | + | 24336569 | HL60 | viability | GGTGCTGAGGCACCAGCCCGCGG | PRKAR2B | ENSG00000005249 | -0.4648969397428241 | [601] | [922] | -4 | hSpCas9 | negative selection | 2286397 | 107044973 | 107044996 | 7 | + | 24336569 | HL60 | viability | GCACCAGCCCGCGGACCTGCTGG | PRKAR2B | ENSG00000005249 | -0.32687513856807393 | [715] | [1207] | -3 | hSpCas9 | negative selection | 2286398 | 107044980 | 107045003 | 7 | - | 24336569 | HL60 | viability | GCGAACTCCAGCAGGTCCGCGGG | PRKAR2B | ENSG00000005249 | 0.3787900820542254 | [796] | [2192] | 3 | hSpCas9 | negative selection | 2286399 | 107044988 | 107045011 | 7 | - | 24336569 | HL60 | viability | GCTGCAGCGCGAACTCCAGCAGG | PRKAR2B | ENSG00000005249 | 0.6652615335129237 | [603] | [2026] | 5 | hSpCas9 | negative selection | 2286400 | 107045009 | 107045032 | 7 | + | 24336569 | HL60 | viability | GCACTTCACCCGCCTGCAGCAGG | PRKAR2B | ENSG00000005249 | 3.9409037123995585 | [1] | [64] | 9 | hSpCas9 | negative selection | 2286401 | 107044904 | 107044927 | 7 | + | 24336569 | KBM7 | viability | CAGGATGAGCATCGAGATCCCGG | PRKAR2B | ENSG00000005249 | 0.3652927304762874 | [782] | [2750] | 3 | hSpCas9 | negative selection | 2353569 | 107044916 | 107044939 | 7 | + | 24336569 | KBM7 | viability | CGAGATCCCGGCGGGACTGACGG | PRKAR2B | ENSG00000005249 | 1.5117788189537715 | [134] | [1049] | 9 | hSpCas9 | negative selection | 2353570 | 107044922 | 107044945 | 7 | - | 24336569 | KBM7 | viability | GCAGCTCCGTCAGTCCCGCCGGG | PRKAR2B | ENSG00000005249 | 3.5506517105980615 | [50] | [1629] | 9 | hSpCas9 | negative selection | 2353571 | 107044928 | 107044951 | 7 | + | 24336569 | KBM7 | viability | GGGACTGACGGAGCTGCTGCAGG | PRKAR2B | ENSG00000005249 | 0.5632221644192088 | [498] | [2010] | 5 | hSpCas9 | negative selection | 2353572 | 107044937 | 107044960 | 7 | + | 24336569 | KBM7 | viability | GGAGCTGCTGCAGGGCTTCACGG | PRKAR2B | ENSG00000005249 | 1.0165624982305437 | [138] | [766] | 8 | hSpCas9 | negative selection | 2353573 | 107044964 | 107044987 | 7 | + | 24336569 | KBM7 | viability | GGTGCTGAGGCACCAGCCCGCGG | PRKAR2B | ENSG00000005249 | 0.7686748559489026 | [285] | [1328] | 7 | hSpCas9 | negative selection | 2353574 | 107044973 | 107044996 | 7 | + | 24336569 | KBM7 | viability | GCACCAGCCCGCGGACCTGCTGG | PRKAR2B | ENSG00000005249 | 0.06786019968779891 | [332] | [951] | 0 | hSpCas9 | negative selection | 2353575 | 107044980 | 107045003 | 7 | - | 24336569 | KBM7 | viability | GCGAACTCCAGCAGGTCCGCGGG | PRKAR2B | ENSG00000005249 | 0.14130687210837223 | [611] | [1840] | 1 | hSpCas9 | negative selection | 2353576 | 107044988 | 107045011 | 7 | - | 24336569 | KBM7 | viability | GCTGCAGCGCGAACTCCAGCAGG | PRKAR2B | ENSG00000005249 | 0.3597757255087215 | [415] | [1455] | 3 | hSpCas9 | negative selection | 2353577 | 107045009 | 107045032 | 7 | + | 24336569 | KBM7 | viability | GCACTTCACCCGCCTGCAGCAGG | PRKAR2B | ENSG00000005249 | 4.978685558153217 | [0] | [85] | 9 | hSpCas9 | negative selection | 2353578 | 107063201 | 107063224 | 7 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GGAGTTCAGCCTGGCCAACATGG | PRKAR2B | ENSG00000005249 | 6.570119908559863 | [446,222] | [12631,903] | 9 | dCas9-VP64 | positive selection | 2455662 | 107063201 | 107063224 | 7 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GGAGTTCAGCCTGGCCAACATGG | PRKAR2B | ENSG00000005249 | 0.905371279890363 | [221,293] | [157,156] | 6 | dCas9-VP64 | positive selection | 2550917 | 107157245 | 107157268 | 7 | + | 27013184 | SW480 | treatment with recombinant TRAIL | GTACTTTGGAGAGCTTGCCCTGG | PRKAR2B | ENSG00000005249 | -0.4863859091438234 | [320,265] | [98,79] | -2 | hSpCas9 | positive selection | 2957963 | 107044909 | 107044932 | 7 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | ATGAGCATCGAGATCCCGGCGGG | PRKAR2B | ENSG00000005249 | 0.1533374102190529 | [3,3] | [4,2] | 3 | hSpCas9 | positive selection | 3013653 | 107045121 | 107045144 | 7 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | CAAGGGGGTCAACTTCGCCGAGG | PRKAR2B | ENSG00000005249 | -0.07287748542486572 | [2,3] | [3,1] | -1 | hSpCas9 | positive selection | 3013654 | 107044908 | 107044931 | 7 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -0.2233406581262819 | [3,3] | [3,1] | -3 | hSpCas9 | positive selection | 3013655 | 107044930 | 107044953 | 7 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | GGACTGACGGAGCTGCTGCAGGG | PRKAR2B | ENSG00000005249 | 0.5040796522785332 | [1,2] | [2,2] | 8 | hSpCas9 | positive selection | 3013656 | 107044909 | 107044932 | 7 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | ATGAGCATCGAGATCCCGGCGGG | PRKAR2B | ENSG00000005249 | 0.00707511043522413 | [3,3] | [3,1] | 0 | hSpCas9 | positive selection | 3081511 | 107045121 | 107045144 | 7 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | CAAGGGGGTCAACTTCGCCGAGG | PRKAR2B | ENSG00000005249 | -0.7099476123490074 | [2,2] | [1,0] | -8 | hSpCas9 | positive selection | 3081512 | 107044908 | 107044931 | 7 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -0.21803314991346512 | [3,3] | [2,1] | -3 | hSpCas9 | positive selection | 3081513 | 107044930 | 107044953 | 7 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | GGACTGACGGAGCTGCTGCAGGG | PRKAR2B | ENSG00000005249 | 0.20780819648045723 | [1,1] | [2,0] | 3 | hSpCas9 | positive selection | 3081514 | 107044908 | 107044931 | 7 | + | 26780180 | HT29 | viability (Avana library 4 designs) | ATGAGCATCGAGATCCCGGCGGG | PRKAR2B | ENSG00000005249 | 0.120479784222654 | [] | [] | 0 | hSpCas9 | negative selection | 3451840 | 107045120 | 107045143 | 7 | + | 26780180 | HT29 | viability (Avana library 4 designs) | CAAGGGGGTCAACTTCGCCGAGG | PRKAR2B | ENSG00000005249 | 0.422413340457434 | [] | [] | 1 | hSpCas9 | negative selection | 3451841 | 107044907 | 107044930 | 7 | + | 26780180 | HT29 | viability (Avana library 4 designs) | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 1.20467498262474 | [] | [] | 5 | hSpCas9 | negative selection | 3451842 | 107044929 | 107044952 | 7 | + | 26780180 | HT29 | viability (Avana library 4 designs) | GGACTGACGGAGCTGCTGCAGGG | PRKAR2B | ENSG00000005249 | 1.98687387733502 | [] | [] | 7 | hSpCas9 | negative selection | 3451843 | 107044907 | 107044930 | 7 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -1.95879406779489 | [] | [] | -2 | hSpCas9 | negative selection | 3547926 | 107045120 | 107045143 | 7 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | CAAGGGGGTCAACTTCGCCGAGG | PRKAR2B | ENSG00000005249 | 2.87696959983364 | [] | [] | 4 | hSpCas9 | negative selection | 3547927 | 107044929 | 107044952 | 7 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GGACTGACGGAGCTGCTGCAGGG | PRKAR2B | ENSG00000005249 | 5.36006599473665 | [] | [] | 8 | hSpCas9 | negative selection | 3547928 | 107044908 | 107044931 | 7 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | ATGAGCATCGAGATCCCGGCGGG | PRKAR2B | ENSG00000005249 | 2.05918514482775 | [] | [] | 3 | hSpCas9 | negative selection | 3547929 | 107044940 | 107044963 | 7 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GCTGCTGCAGGGCTTCACGGTGG | PRKAR2B | ENSG00000005249 | -0.513484969114706 | [] | [] | 0 | hSpCas9 | negative selection | 3547930 | 107044988 | 107045011 | 7 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GCTGCAGCGCGAACTCCAGCAGG | PRKAR2B | ENSG00000005249 | 5.4666608206306 | [] | [] | 8 | hSpCas9 | negative selection | 3547931 | 107044907 | 107044930 | 7 | + | 26780180 | A375 | viability (Avana lentiGuide) | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -0.314724603791771 | [] | [] | 0 | hSpCas9 | negative selection | 3656585 | 107045120 | 107045143 | 7 | + | 26780180 | A375 | viability (Avana lentiGuide) | CAAGGGGGTCAACTTCGCCGAGG | PRKAR2B | ENSG00000005249 | -4.58421252449979 | [] | [] | -7 | hSpCas9 | negative selection | 3656586 | 107044929 | 107044952 | 7 | + | 26780180 | A375 | viability (Avana lentiGuide) | GGACTGACGGAGCTGCTGCAGGG | PRKAR2B | ENSG00000005249 | -2.67082365371646 | [] | [] | -5 | hSpCas9 | negative selection | 3656587 | 107044908 | 107044931 | 7 | + | 26780180 | A375 | viability (Avana lentiGuide) | ATGAGCATCGAGATCCCGGCGGG | PRKAR2B | ENSG00000005249 | 1.38449778546613 | [] | [] | 1 | hSpCas9 | negative selection | 3656588 | 107044940 | 107044963 | 7 | + | 26780180 | A375 | viability (Avana lentiGuide) | GCTGCTGCAGGGCTTCACGGTGG | PRKAR2B | ENSG00000005249 | 8.23950966970725 | [] | [] | 6 | hSpCas9 | negative selection | 3656589 | 107044988 | 107045011 | 7 | - | 26780180 | A375 | viability (Avana lentiGuide) | GCTGCAGCGCGAACTCCAGCAGG | PRKAR2B | ENSG00000005249 | -2.10117088101754 | [] | [] | -4 | hSpCas9 | negative selection | 3656590 | 107044907 | 107044930 | 7 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -0.1636105735530596 | [4] | [3,3] | -3 | hSpCas9 | positive selection | 3765192 | 107045120 | 107045143 | 7 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | CAAGGGGGTCAACTTCGCCGAGG | PRKAR2B | ENSG00000005249 | -0.5115760770496286 | [4] | [2,2] | -6 | hSpCas9 | positive selection | 3765193 | 107044929 | 107044952 | 7 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GGACTGACGGAGCTGCTGCAGGG | PRKAR2B | ENSG00000005249 | 0.2354682635173656 | [3] | [3,4] | 6 | hSpCas9 | positive selection | 3765194 | 107044908 | 107044931 | 7 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | ATGAGCATCGAGATCCCGGCGGG | PRKAR2B | ENSG00000005249 | 0.15761970427786276 | [5] | [5,5] | 4 | hSpCas9 | positive selection | 3765195 | 107044940 | 107044963 | 7 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GCTGCTGCAGGGCTTCACGGTGG | PRKAR2B | ENSG00000005249 | 0.0901759803375771 | [4] | [5,4] | 2 | hSpCas9 | positive selection | 3765196 | 107044988 | 107045011 | 7 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GCTGCAGCGCGAACTCCAGCAGG | PRKAR2B | ENSG00000005249 | 0.23301200285987017 | [4] | [5,4] | 6 | hSpCas9 | positive selection | 3765197 | 107044907 | 107044930 | 7 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 0.23472441831038104 | [5] | [6,5] | 6 | hSpCas9 | positive selection | 3873799 | 107045120 | 107045143 | 7 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | CAAGGGGGTCAACTTCGCCGAGG | PRKAR2B | ENSG00000005249 | -0.160004290139592 | [4] | [3,3] | -2 | hSpCas9 | positive selection | 3873800 | 107044929 | 107044952 | 7 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GGACTGACGGAGCTGCTGCAGGG | PRKAR2B | ENSG00000005249 | 0.35910826357377057 | [3] | [3,4] | 9 | hSpCas9 | positive selection | 3873801 | 107044908 | 107044931 | 7 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | ATGAGCATCGAGATCCCGGCGGG | PRKAR2B | ENSG00000005249 | 0.28313452247335447 | [5] | [5,6] | 7 | hSpCas9 | positive selection | 3873802 | 107044940 | 107044963 | 7 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GCTGCTGCAGGGCTTCACGGTGG | PRKAR2B | ENSG00000005249 | -0.09939182667554723 | [6] | [4,5] | -1 | hSpCas9 | positive selection | 3873803 | 107044988 | 107045011 | 7 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GCTGCAGCGCGAACTCCAGCAGG | PRKAR2B | ENSG00000005249 | 0.4129151063777449 | [5] | [5,6] | 9 | hSpCas9 | positive selection | 3873804 | 107045049 | 107045071 | 7 | + | 27760321 | OCIAML3 | viability | ACCGCGCGCTTCGGCCATGAGG | PRKAR2B | ENSG00000005249 | 0.17328726032550978 | [1319,1014] | [968,1090] | 2 | hSpCas9 | negative selection | 4430590 | 107045121 | 107045143 | 7 | + | 27760321 | OCIAML3 | viability | AAGGGGGTCAACTTCGCCGAGG | PRKAR2B | ENSG00000005249 | -0.12385416926559129 | [636,469] | [341,460] | -1 | hSpCas9 | negative selection | 4430591 | 107045191 | 107045213 | 7 | - | 27760321 | OCIAML3 | viability | TTGAACGCCCCTGCGTCCGCGG | PRKAR2B | ENSG00000005249 | 0.3452627198236624 | [823,697] | [808,680] | 4 | hSpCas9 | negative selection | 4430592 | 107140908 | 107140930 | 7 | + | 27760321 | OCIAML3 | viability | TAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | -0.5719337827812512 | [214,172] | [84,122] | -5 | hSpCas9 | negative selection | 4430593 | 107045049 | 107045071 | 7 | + | 27760321 | OCIAML2 | viability | ACCGCGCGCTTCGGCCATGAGG | PRKAR2B | ENSG00000005249 | 0.27577431165601807 | [1319,1014] | [919,1417] | 3 | hSpCas9 | negative selection | 4514053 | 107045121 | 107045143 | 7 | + | 27760321 | OCIAML2 | viability | AAGGGGGTCAACTTCGCCGAGG | PRKAR2B | ENSG00000005249 | 0.0974411598862232 | [636,469] | [415,551] | 1 | hSpCas9 | negative selection | 4514054 | 107045191 | 107045213 | 7 | - | 27760321 | OCIAML2 | viability | TTGAACGCCCCTGCGTCCGCGG | PRKAR2B | ENSG00000005249 | 0.43622395647857415 | [823,697] | [760,920] | 6 | hSpCas9 | negative selection | 4514055 | 107140908 | 107140930 | 7 | + | 27760321 | OCIAML2 | viability | TAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | 0.2483045057602592 | [214,172] | [193,173] | 3 | hSpCas9 | negative selection | 4514056 | 107045049 | 107045071 | 7 | + | 27760321 | MV411 | viability | ACCGCGCGCTTCGGCCATGAGG | PRKAR2B | ENSG00000005249 | 0.9225355522670784 | [1319,1014] | [1271,1715] | 6 | hSpCas9 | negative selection | 4597516 | 107045121 | 107045143 | 7 | + | 27760321 | MV411 | viability | AAGGGGGTCAACTTCGCCGAGG | PRKAR2B | ENSG00000005249 | -0.4319224652982191 | [636,469] | [135,466] | -3 | hSpCas9 | negative selection | 4597517 | 107045191 | 107045213 | 7 | - | 27760321 | MV411 | viability | TTGAACGCCCCTGCGTCCGCGG | PRKAR2B | ENSG00000005249 | -0.025637423733720355 | [823,697] | [258,840] | 0 | hSpCas9 | negative selection | 4597518 | 107140908 | 107140930 | 7 | + | 27760321 | MV411 | viability | TAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | 1.3002488300377062 | [214,172] | [448,109] | 8 | hSpCas9 | negative selection | 4597519 | 107045049 | 107045071 | 7 | + | 27760321 | HL60 | viability | ACCGCGCGCTTCGGCCATGAGG | PRKAR2B | ENSG00000005249 | 0.4449363032595053 | [1319,1014] | [1141,1443] | 5 | hSpCas9 | negative selection | 4680979 | 107045121 | 107045143 | 7 | + | 27760321 | HL60 | viability | AAGGGGGTCAACTTCGCCGAGG | PRKAR2B | ENSG00000005249 | 0.4293815632047422 | [636,469] | [713,485] | 5 | hSpCas9 | negative selection | 4680980 | 107045191 | 107045213 | 7 | - | 27760321 | HL60 | viability | TTGAACGCCCCTGCGTCCGCGG | PRKAR2B | ENSG00000005249 | 0.21741147844744302 | [823,697] | [660,782] | 2 | hSpCas9 | negative selection | 4680981 | 107140908 | 107140930 | 7 | + | 27760321 | HL60 | viability | TAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | -0.6486782493847003 | [214,172] | [67,134] | -6 | hSpCas9 | negative selection | 4680982 | 107045049 | 107045071 | 7 | + | 27760321 | HT1080 | viability | ACCGCGCGCTTCGGCCATGAGG | PRKAR2B | ENSG00000005249 | 0.3723395564487595 | [1014,791] | [505,421] | 2 | hSpCas9 | negative selection | 4764442 | 107045121 | 107045143 | 7 | + | 27760321 | HT1080 | viability | AAGGGGGTCAACTTCGCCGAGG | PRKAR2B | ENSG00000005249 | 0.7657076483624755 | [469,366] | [229,341] | 4 | hSpCas9 | negative selection | 4764443 | 107045191 | 107045213 | 7 | - | 27760321 | HT1080 | viability | TTGAACGCCCCTGCGTCCGCGG | PRKAR2B | ENSG00000005249 | 0.7174849235128518 | [697,544] | [356,461] | 4 | hSpCas9 | negative selection | 4764444 | 107140908 | 107140930 | 7 | + | 27760321 | HT1080 | viability | TAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | 0.8413521383575433 | [172,134] | [181,30] | 4 | hSpCas9 | negative selection | 4764445 | 107045049 | 107045071 | 7 | + | 27760321 | HT29 | viability after 7 days | ACCGCGCGCTTCGGCCATGAGG | PRKAR2B | ENSG00000005249 | 0.5815160501239396 | [1014,791] | [2109,1978,1193] | 8 | hSpCas9 | negative selection | 4847905 | 107045121 | 107045143 | 7 | + | 27760321 | HT29 | viability after 7 days | AAGGGGGTCAACTTCGCCGAGG | PRKAR2B | ENSG00000005249 | -0.01621700883612051 | [469,366] | [393,561,616] | 0 | hSpCas9 | negative selection | 4847906 | 107045191 | 107045213 | 7 | - | 27760321 | HT29 | viability after 7 days | TTGAACGCCCCTGCGTCCGCGG | PRKAR2B | ENSG00000005249 | 0.0753539382406836 | [697,544] | [806,882,829] | 1 | hSpCas9 | negative selection | 4847907 | 107140908 | 107140930 | 7 | + | 27760321 | HT29 | viability after 7 days | TAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | -0.5956942869701829 | [172,134] | [127,182,82] | -7 | hSpCas9 | negative selection | 4847908 | 107045049 | 107045071 | 7 | + | 27760321 | HT29 | viability after 25 days | ACCGCGCGCTTCGGCCATGAGG | PRKAR2B | ENSG00000005249 | 0.8176882586266006 | [1014,791] | [1725,1760,1993] | 8 | hSpCas9 | negative selection | 4931368 | 107045121 | 107045143 | 7 | + | 27760321 | HT29 | viability after 25 days | AAGGGGGTCAACTTCGCCGAGG | PRKAR2B | ENSG00000005249 | 0.5281670089187528 | [469,366] | [606,753,714] | 6 | hSpCas9 | negative selection | 4931369 | 107045191 | 107045213 | 7 | - | 27760321 | HT29 | viability after 25 days | TTGAACGCCCCTGCGTCCGCGG | PRKAR2B | ENSG00000005249 | 0.33319620938980554 | [697,544] | [854,940,888] | 3 | hSpCas9 | negative selection | 4931370 | 107140908 | 107140930 | 7 | + | 27760321 | HT29 | viability after 25 days | TAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | 0.13052014868983863 | [172,134] | [301,194,59] | 1 | hSpCas9 | negative selection | 4931371 | 107045049 | 107045071 | 7 | + | 27760321 | HT29 | viability after 22 days | ACCGCGCGCTTCGGCCATGAGG | PRKAR2B | ENSG00000005249 | 0.9286809516798717 | [1014,791] | [1980,1755,2229] | 9 | hSpCas9 | negative selection | 5014831 | 107045121 | 107045143 | 7 | + | 27760321 | HT29 | viability after 22 days | AAGGGGGTCAACTTCGCCGAGG | PRKAR2B | ENSG00000005249 | 0.5174430830290622 | [469,366] | [421,858,804] | 6 | hSpCas9 | negative selection | 5014832 | 107045191 | 107045213 | 7 | - | 27760321 | HT29 | viability after 22 days | TTGAACGCCCCTGCGTCCGCGG | PRKAR2B | ENSG00000005249 | 0.11681857672819629 | [697,544] | [747,718,871] | 1 | hSpCas9 | negative selection | 5014833 | 107140908 | 107140930 | 7 | + | 27760321 | HT29 | viability after 22 days | TAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | 0.1441617904227055 | [172,134] | [290,168,126] | 1 | hSpCas9 | negative selection | 5014834 | 107045049 | 107045071 | 7 | + | 27760321 | HT29 | viability after 19 days | ACCGCGCGCTTCGGCCATGAGG | PRKAR2B | ENSG00000005249 | 0.7468510108845008 | [1014,791] | [1862,1393,1948] | 7 | hSpCas9 | negative selection | 5098294 | 107045121 | 107045143 | 7 | + | 27760321 | HT29 | viability after 19 days | AAGGGGGTCAACTTCGCCGAGG | PRKAR2B | ENSG00000005249 | 0.332636040989135 | [469,366] | [847,662,332] | 3 | hSpCas9 | negative selection | 5098295 | 107045191 | 107045213 | 7 | - | 27760321 | HT29 | viability after 19 days | TTGAACGCCCCTGCGTCCGCGG | PRKAR2B | ENSG00000005249 | 0.11465681978018905 | [697,544] | [620,881,788] | 1 | hSpCas9 | negative selection | 5098296 | 107140908 | 107140930 | 7 | + | 27760321 | HT29 | viability after 19 days | TAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | -0.9937785975755562 | [172,134] | [135,65,68] | -6 | hSpCas9 | negative selection | 5098297 | 107045049 | 107045071 | 7 | + | 27760321 | HT29 | viability after 16 days | ACCGCGCGCTTCGGCCATGAGG | PRKAR2B | ENSG00000005249 | 0.8302622637093409 | [1014,791] | [1957,1822,1624] | 8 | hSpCas9 | negative selection | 5181757 | 107045121 | 107045143 | 7 | + | 27760321 | HT29 | viability after 16 days | AAGGGGGTCAACTTCGCCGAGG | PRKAR2B | ENSG00000005249 | 0.47708812402971 | [469,366] | [656,637,660] | 5 | hSpCas9 | negative selection | 5181758 | 107045191 | 107045213 | 7 | - | 27760321 | HT29 | viability after 16 days | TTGAACGCCCCTGCGTCCGCGG | PRKAR2B | ENSG00000005249 | -0.05686289704645919 | [697,544] | [958,506,570] | 0 | hSpCas9 | negative selection | 5181759 | 107140908 | 107140930 | 7 | + | 27760321 | HT29 | viability after 16 days | TAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | -0.478014811185026 | [172,134] | [145,130,95] | -5 | hSpCas9 | negative selection | 5181760 | 107045049 | 107045071 | 7 | + | 27760321 | HT29 | viability after 13 days | ACCGCGCGCTTCGGCCATGAGG | PRKAR2B | ENSG00000005249 | 0.8394850566736967 | [1014,791] | [2092,1813,1727] | 9 | hSpCas9 | negative selection | 5265220 | 107045121 | 107045143 | 7 | + | 27760321 | HT29 | viability after 13 days | AAGGGGGTCAACTTCGCCGAGG | PRKAR2B | ENSG00000005249 | 0.5171070066033119 | [469,366] | [439,763,869] | 6 | hSpCas9 | negative selection | 5265221 | 107045191 | 107045213 | 7 | - | 27760321 | HT29 | viability after 13 days | TTGAACGCCCCTGCGTCCGCGG | PRKAR2B | ENSG00000005249 | 0.2202043361301922 | [697,544] | [911,708,894] | 2 | hSpCas9 | negative selection | 5265222 | 107140908 | 107140930 | 7 | + | 27760321 | HT29 | viability after 13 days | TAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | -0.0925348202012557 | [172,134] | [187,119,192] | -1 | hSpCas9 | negative selection | 5265223 | 107045049 | 107045071 | 7 | + | 27760321 | HT29 | viability after 10 days | ACCGCGCGCTTCGGCCATGAGG | PRKAR2B | ENSG00000005249 | 0.7681183027044876 | [1014,791] | [2313,1783,1666] | 9 | hSpCas9 | negative selection | 5348683 | 107045121 | 107045143 | 7 | + | 27760321 | HT29 | viability after 10 days | AAGGGGGTCAACTTCGCCGAGG | PRKAR2B | ENSG00000005249 | 0.21721207581433102 | [469,366] | [718,512,587] | 3 | hSpCas9 | negative selection | 5348684 | 107045191 | 107045213 | 7 | - | 27760321 | HT29 | viability after 10 days | TTGAACGCCCCTGCGTCCGCGG | PRKAR2B | ENSG00000005249 | 0.3110311326123405 | [697,544] | [795,777,1300] | 4 | hSpCas9 | negative selection | 5348685 | 107140908 | 107140930 | 7 | + | 27760321 | HT29 | viability after 10 days | TAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | -0.2227559614429373 | [172,134] | [247,81,161] | -3 | hSpCas9 | negative selection | 5348686 | 107045049 | 107045071 | 7 | + | 27760321 | MOLM13 | viability | ACCGCGCGCTTCGGCCATGAGG | PRKAR2B | ENSG00000005249 | 0.9888699649063837 | [1319,1014] | [1612,1028] | 7 | hSpCas9 | negative selection | 5432146 | 107045121 | 107045143 | 7 | + | 27760321 | MOLM13 | viability | AAGGGGGTCAACTTCGCCGAGG | PRKAR2B | ENSG00000005249 | 1.367443644343418 | [636,469] | [1014,613] | 8 | hSpCas9 | negative selection | 5432147 | 107045191 | 107045213 | 7 | - | 27760321 | MOLM13 | viability | TTGAACGCCCCTGCGTCCGCGG | PRKAR2B | ENSG00000005249 | 1.2274991054171018 | [823,697] | [1662,438] | 8 | hSpCas9 | negative selection | 5432148 | 107140908 | 107140930 | 7 | + | 27760321 | MOLM13 | viability | TAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | 0.3598536725966899 | [214,172] | [291,9] | 2 | hSpCas9 | negative selection | 5432149 | 107045153 | 107045176 | 7 | + | 27661255 | K562 | viability | GTCCGACTCCGAGGACGGGGAGG | PRKAR2B | ENSG00000005249 | -0.004618060852398574 | [812,723] | [657,574] | 0 | dCas9-KRAB | negative selection | 5504140 | 107044715 | 107044738 | 7 | - | 27661255 | K562 | viability | GCGTCTGCTCCGTGTGGTGGCGG | PRKAR2B | ENSG00000005249 | 0.08140762839184223 | [339,476] | [367,321] | 3 | dCas9-KRAB | negative selection | 5504141 | 107045137 | 107045160 | 7 | - | 27661255 | K562 | viability | GTCGGACTGCATGGGCTCCTCGG | PRKAR2B | ENSG00000005249 | 0.2614264199342669 | [410,572] | [558,390] | 8 | dCas9-KRAB | negative selection | 5504142 | 107044907 | 107044930 | 7 | + | 27869803 | HPAFII | viability after 27 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -1.2588326698551784 | [23] | [1,7,NaN] | -7 | hSpCas9 | negative selection | 9597540 | 107045149 | 107045172 | 7 | + | 27869803 | HPAFII | viability after 27 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | -0.011391434305249915 | [586] | [405,222,NaN] | 0 | hSpCas9 | negative selection | 9597541 | 107146371 | 107146394 | 7 | + | 27869803 | HPAFII | viability after 27 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | -0.1940908661427163 | [434] | [260,148,NaN] | -1 | hSpCas9 | negative selection | 9597542 | 107150905 | 107150928 | 7 | + | 27869803 | HPAFII | viability after 27 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | 1.4560760034378315 | [194] | [289,273,NaN] | 9 | hSpCas9 | negative selection | 9597543 | 107153210 | 107153233 | 7 | + | 27869803 | HPAFII | viability after 27 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -1.0940935884826661 | [188] | [9,76,NaN] | -6 | hSpCas9 | negative selection | 9597544 | 107157296 | 107157319 | 7 | - | 27869803 | HPAFII | viability after 27 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -0.02777427998368759 | [268] | [183,100,NaN] | 0 | hSpCas9 | negative selection | 9597545 | 107044907 | 107044930 | 7 | + | 27869803 | HPAFII | viability after 15 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 0.2990653498400797 | [23] | [48,20,NaN] | 3 | hSpCas9 | negative selection | 9679989 | 107045149 | 107045172 | 7 | + | 27869803 | HPAFII | viability after 15 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | -0.08573086681493569 | [586] | [977,355,NaN] | -1 | hSpCas9 | negative selection | 9679990 | 107146371 | 107146394 | 7 | + | 27869803 | HPAFII | viability after 15 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | -0.0985526236372728 | [434] | [657,298,NaN] | -1 | hSpCas9 | negative selection | 9679991 | 107150905 | 107150928 | 7 | + | 27869803 | HPAFII | viability after 15 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | 1.427134558450517 | [194] | [549,571,NaN] | 9 | hSpCas9 | negative selection | 9679992 | 107153210 | 107153233 | 7 | + | 27869803 | HPAFII | viability after 15 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -2.008863536529629 | [188] | [84,28,NaN] | -9 | hSpCas9 | negative selection | 9679993 | 107157296 | 107157319 | 7 | - | 27869803 | HPAFII | viability after 15 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -0.7034311856812167 | [268] | [253,129,NaN] | -6 | hSpCas9 | negative selection | 9679994 | 107044907 | 107044930 | 7 | + | 27869803 | ASPC1 | viability after 36 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -5.075425489605308 | [96] | [0,0,0] | -9 | hSpCas9 | negative selection | 9762438 | 107045149 | 107045172 | 7 | + | 27869803 | ASPC1 | viability after 36 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | 0.3513831810167698 | [1428] | [767,1044,212] | 3 | hSpCas9 | negative selection | 9762439 | 107146371 | 107146394 | 7 | + | 27869803 | ASPC1 | viability after 36 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | -0.6790770009262982 | [1476] | [273,203,445] | -6 | hSpCas9 | negative selection | 9762440 | 107150905 | 107150928 | 7 | + | 27869803 | ASPC1 | viability after 36 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | 1.1503183401058412 | [462] | [583,272,264] | 9 | hSpCas9 | negative selection | 9762441 | 107153210 | 107153233 | 7 | + | 27869803 | ASPC1 | viability after 36 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -0.15672136021332128 | [447] | [10,344,66] | -2 | hSpCas9 | negative selection | 9762442 | 107157296 | 107157319 | 7 | - | 27869803 | ASPC1 | viability after 36 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -0.40207983072806586 | [809] | [145,279,206] | -4 | hSpCas9 | negative selection | 9762443 | 107044907 | 107044930 | 7 | + | 27869803 | PATU8988S | viability after 35 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -1.1581795629268874 | [93] | [0,32,NaN] | -8 | hSpCas9 | negative selection | 9844887 | 107045149 | 107045172 | 7 | + | 27869803 | PATU8988S | viability after 35 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | -0.003692592677828621 | [1375] | [669,434,NaN] | 0 | hSpCas9 | negative selection | 9844888 | 107146371 | 107146394 | 7 | + | 27869803 | PATU8988S | viability after 35 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | -0.22660484172127837 | [1164] | [401,399,NaN] | -2 | hSpCas9 | negative selection | 9844889 | 107150905 | 107150928 | 7 | + | 27869803 | PATU8988S | viability after 35 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | 0.3073984442914862 | [583] | [317,263,NaN] | 3 | hSpCas9 | negative selection | 9844890 | 107153210 | 107153233 | 7 | + | 27869803 | PATU8988S | viability after 35 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -0.44195093031385413 | [458] | [172,98,NaN] | -4 | hSpCas9 | negative selection | 9844891 | 107157296 | 107157319 | 7 | - | 27869803 | PATU8988S | viability after 35 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | 0.2853077507813266 | [546] | [258,277,NaN] | 3 | hSpCas9 | negative selection | 9844892 | 107044907 | 107044930 | 7 | + | 27869803 | PATU8988S | viability after 31 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -2.356331642507374 | [93] | [5,8,NaN] | -9 | hSpCas9 | negative selection | 9927336 | 107045149 | 107045172 | 7 | + | 27869803 | PATU8988S | viability after 31 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | -0.04301548295435431 | [1375] | [499,573,NaN] | 0 | hSpCas9 | negative selection | 9927337 | 107146371 | 107146394 | 7 | + | 27869803 | PATU8988S | viability after 31 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | -0.188087929527066 | [1164] | [383,437,NaN] | -2 | hSpCas9 | negative selection | 9927338 | 107150905 | 107150928 | 7 | + | 27869803 | PATU8988S | viability after 31 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | 0.2686337092237018 | [583] | [309,242,NaN] | 3 | hSpCas9 | negative selection | 9927339 | 107153210 | 107153233 | 7 | + | 27869803 | PATU8988S | viability after 31 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -1.0983559023648528 | [458] | [88,80,NaN] | -8 | hSpCas9 | negative selection | 9927340 | 107157296 | 107157319 | 7 | - | 27869803 | PATU8988S | viability after 31 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | 0.4863717769314968 | [546] | [294,318,NaN] | 6 | hSpCas9 | negative selection | 9927341 | 107044907 | 107044930 | 7 | + | 27869803 | HPAFII | viability after 35 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -3.6028739477244818 | [23] | [0,0,NaN] | -9 | hSpCas9 | negative selection | 10009785 | 107045149 | 107045172 | 7 | + | 27869803 | HPAFII | viability after 35 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | -0.32975730773339684 | [586] | [306,156,NaN] | -2 | hSpCas9 | negative selection | 10009786 | 107146371 | 107146394 | 7 | + | 27869803 | HPAFII | viability after 35 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | 0.2715343914926188 | [434] | [262,268,NaN] | 1 | hSpCas9 | negative selection | 10009787 | 107150905 | 107150928 | 7 | + | 27869803 | HPAFII | viability after 35 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | 0.8867764575654831 | [194] | [190,172,NaN] | 6 | hSpCas9 | negative selection | 10009788 | 107153210 | 107153233 | 7 | + | 27869803 | HPAFII | viability after 35 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -0.5571720894183256 | [188] | [1,135,NaN] | -3 | hSpCas9 | negative selection | 10009789 | 107157296 | 107157319 | 7 | - | 27869803 | HPAFII | viability after 35 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -0.5060754542463867 | [268] | [109,79,NaN] | -3 | hSpCas9 | negative selection | 10009790 | 107044907 | 107044930 | 7 | + | 27869803 | HPAFII | viability after 31 days | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -3.146164697765027 | [23] | [1,0,NaN] | -9 | hSpCas9 | negative selection | 10092234 | 107045149 | 107045172 | 7 | + | 27869803 | HPAFII | viability after 31 days | TGCAGTCCGACTCCGAGGACGGG | PRKAR2B | ENSG00000005249 | -0.2601080839052642 | [586] | [343,199,NaN] | -2 | hSpCas9 | negative selection | 10092235 | 107146371 | 107146394 | 7 | + | 27869803 | HPAFII | viability after 31 days | TCGTGGGAGTTTCGGCGAACTGG | PRKAR2B | ENSG00000005249 | -0.060387214384635124 | [434] | [247,218,NaN] | 0 | hSpCas9 | negative selection | 10092236 | 107150905 | 107150928 | 7 | + | 27869803 | HPAFII | viability after 31 days | AACTGTTCTGCCTGTAGGACAGG | PRKAR2B | ENSG00000005249 | 0.9961147919037916 | [194] | [179,259,NaN] | 7 | hSpCas9 | negative selection | 10092237 | 107153210 | 107153233 | 7 | + | 27869803 | HPAFII | viability after 31 days | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -0.7036525476260161 | [188] | [0,134,NaN] | -4 | hSpCas9 | negative selection | 10092238 | 107157296 | 107157319 | 7 | - | 27869803 | HPAFII | viability after 31 days | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -0.027385034824525895 | [268] | [150,144,NaN] | 0 | hSpCas9 | negative selection | 10092239 | 107044907 | 107044930 | 7 | + | 28162770 | P31FUJ | viability | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 0.6203564072563503 | [123] | [223] | 7 | hSpCas9 | negative selection | 10217039 | 107146336 | 107146359 | 7 | + | 28162770 | P31FUJ | viability | GATGGTGTTGGAAGATGTGTTGG | PRKAR2B | ENSG00000005249 | 0.36608725434885514 | [755] | [1144] | 4 | hSpCas9 | negative selection | 10217040 | 107044940 | 107044963 | 7 | + | 28162770 | P31FUJ | viability | GCTGCTGCAGGGCTTCACGGTGG | PRKAR2B | ENSG00000005249 | 0.32749824207250844 | [117] | [173] | 3 | hSpCas9 | negative selection | 10217041 | 107045153 | 107045176 | 7 | + | 28162770 | P31FUJ | viability | GTCCGACTCCGAGGACGGGGAGG | PRKAR2B | ENSG00000005249 | -0.30151495449839283 | [85] | [81] | -3 | hSpCas9 | negative selection | 10217042 | 107044964 | 107044987 | 7 | + | 28162770 | P31FUJ | viability | GGTGCTGAGGCACCAGCCCGCGG | PRKAR2B | ENSG00000005249 | -0.6478397036932222 | [31] | [23] | -5 | hSpCas9 | negative selection | 10217043 | 107140907 | 107140930 | 7 | + | 28162770 | P31FUJ | viability | GTAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | 0.473466592528911 | [246] | [402] | 5 | hSpCas9 | negative selection | 10217044 | 107153210 | 107153233 | 7 | + | 28162770 | P31FUJ | viability | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -0.5400835233373397 | [244] | [197] | -4 | hSpCas9 | negative selection | 10217045 | 107157296 | 107157319 | 7 | - | 28162770 | P31FUJ | viability | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -0.6343185640396036 | [176] | [133] | -5 | hSpCas9 | negative selection | 10217046 | 107044922 | 107044945 | 7 | - | 28162770 | P31FUJ | viability | GCAGCTCCGTCAGTCCCGCCGGG | PRKAR2B | ENSG00000005249 | -0.20680699588143447 | [54] | [55] | -2 | hSpCas9 | negative selection | 10217047 | 107044980 | 107045003 | 7 | - | 28162770 | P31FUJ | viability | GCGAACTCCAGCAGGTCCGCGGG | PRKAR2B | ENSG00000005249 | 0.33879307256894875 | [252] | [375] | 4 | hSpCas9 | negative selection | 10217048 | 107044907 | 107044930 | 7 | + | 28162770 | TF1 | viability | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | NaN | [NaN] | [79] | 1 | hSpCas9 | negative selection | 10386405 | 107146336 | 107146359 | 7 | + | 28162770 | TF1 | viability | GATGGTGTTGGAAGATGTGTTGG | PRKAR2B | ENSG00000005249 | NaN | [NaN] | [690] | 1 | hSpCas9 | negative selection | 10386406 | 107044940 | 107044963 | 7 | + | 28162770 | TF1 | viability | GCTGCTGCAGGGCTTCACGGTGG | PRKAR2B | ENSG00000005249 | NaN | [NaN] | [102] | 1 | hSpCas9 | negative selection | 10386407 | 107045153 | 107045176 | 7 | + | 28162770 | TF1 | viability | GTCCGACTCCGAGGACGGGGAGG | PRKAR2B | ENSG00000005249 | NaN | [NaN] | [94] | 1 | hSpCas9 | negative selection | 10386408 | 107044964 | 107044987 | 7 | + | 28162770 | TF1 | viability | GGTGCTGAGGCACCAGCCCGCGG | PRKAR2B | ENSG00000005249 | NaN | [NaN] | [16] | 1 | hSpCas9 | negative selection | 10386409 | 107140907 | 107140930 | 7 | + | 28162770 | TF1 | viability | GTAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | NaN | [NaN] | [243] | 1 | hSpCas9 | negative selection | 10386410 | 107153210 | 107153233 | 7 | + | 28162770 | TF1 | viability | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | NaN | [NaN] | [204] | 1 | hSpCas9 | negative selection | 10386411 | 107157296 | 107157319 | 7 | - | 28162770 | TF1 | viability | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | NaN | [NaN] | [60] | 1 | hSpCas9 | negative selection | 10386412 | 107044922 | 107044945 | 7 | - | 28162770 | TF1 | viability | GCAGCTCCGTCAGTCCCGCCGGG | PRKAR2B | ENSG00000005249 | NaN | [NaN] | [298] | 1 | hSpCas9 | negative selection | 10386413 | 107044980 | 107045003 | 7 | - | 28162770 | TF1 | viability | GCGAACTCCAGCAGGTCCGCGGG | PRKAR2B | ENSG00000005249 | NaN | [NaN] | [297] | 1 | hSpCas9 | negative selection | 10386414 | 107044907 | 107044930 | 7 | + | 28162770 | SKM1 | viability | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -0.5740741845784201 | [31] | [37] | -4 | hSpCas9 | negative selection | 10555771 | 107146336 | 107146359 | 7 | + | 28162770 | SKM1 | viability | GATGGTGTTGGAAGATGTGTTGG | PRKAR2B | ENSG00000005249 | 0.20254048624078624 | [203] | [414] | 2 | hSpCas9 | negative selection | 10555772 | 107044940 | 107044963 | 7 | + | 28162770 | SKM1 | viability | GCTGCTGCAGGGCTTCACGGTGG | PRKAR2B | ENSG00000005249 | 0.6754979614488115 | [16] | [47] | 6 | hSpCas9 | negative selection | 10555773 | 107045153 | 107045176 | 7 | + | 28162770 | SKM1 | viability | GTCCGACTCCGAGGACGGGGAGG | PRKAR2B | ENSG00000005249 | 1.1779983019779945 | [13] | [55] | 9 | hSpCas9 | negative selection | 10555774 | 107044964 | 107044987 | 7 | + | 28162770 | SKM1 | viability | GGTGCTGAGGCACCAGCCCGCGG | PRKAR2B | ENSG00000005249 | 0.6519294903104067 | [8] | [24] | 6 | hSpCas9 | negative selection | 10555775 | 107140907 | 107140930 | 7 | + | 28162770 | SKM1 | viability | GTAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | -0.21754302167505224 | [97] | [148] | -2 | hSpCas9 | negative selection | 10555776 | 107153210 | 107153233 | 7 | + | 28162770 | SKM1 | viability | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | 1.065523572719582 | [59] | [221] | 8 | hSpCas9 | negative selection | 10555777 | 107157296 | 107157319 | 7 | - | 28162770 | SKM1 | viability | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | 0.5930358012568383 | [29] | [79] | 6 | hSpCas9 | negative selection | 10555778 | 107044922 | 107044945 | 7 | - | 28162770 | SKM1 | viability | GCAGCTCCGTCAGTCCCGCCGGG | PRKAR2B | ENSG00000005249 | -0.4594316186372973 | [6] | [8] | -4 | hSpCas9 | negative selection | 10555779 | 107044980 | 107045003 | 7 | - | 28162770 | SKM1 | viability | GCGAACTCCAGCAGGTCCGCGGG | PRKAR2B | ENSG00000005249 | -0.7207183621848239 | [54] | [58] | -5 | hSpCas9 | negative selection | 10555780 | 107044907 | 107044930 | 7 | + | 28162770 | SKM1 | viability | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -0.5740741845784201 | [31] | [37] | -4 | hSpCas9 | negative selection | 10725137 | 107146336 | 107146359 | 7 | + | 28162770 | SKM1 | viability | GATGGTGTTGGAAGATGTGTTGG | PRKAR2B | ENSG00000005249 | 0.20254048624078624 | [203] | [414] | 2 | hSpCas9 | negative selection | 10725138 | 107044940 | 107044963 | 7 | + | 28162770 | SKM1 | viability | GCTGCTGCAGGGCTTCACGGTGG | PRKAR2B | ENSG00000005249 | 0.6754979614488115 | [16] | [47] | 6 | hSpCas9 | negative selection | 10725139 | 107045153 | 107045176 | 7 | + | 28162770 | SKM1 | viability | GTCCGACTCCGAGGACGGGGAGG | PRKAR2B | ENSG00000005249 | 1.1779983019779945 | [13] | [55] | 9 | hSpCas9 | negative selection | 10725140 | 107044964 | 107044987 | 7 | + | 28162770 | SKM1 | viability | GGTGCTGAGGCACCAGCCCGCGG | PRKAR2B | ENSG00000005249 | 0.6519294903104067 | [8] | [24] | 6 | hSpCas9 | negative selection | 10725141 | 107140907 | 107140930 | 7 | + | 28162770 | SKM1 | viability | GTAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | -0.21754302167505224 | [97] | [148] | -2 | hSpCas9 | negative selection | 10725142 | 107153210 | 107153233 | 7 | + | 28162770 | SKM1 | viability | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | 1.065523572719582 | [59] | [221] | 8 | hSpCas9 | negative selection | 10725143 | 107157296 | 107157319 | 7 | - | 28162770 | SKM1 | viability | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | 0.5930358012568383 | [29] | [79] | 6 | hSpCas9 | negative selection | 10725144 | 107044922 | 107044945 | 7 | - | 28162770 | SKM1 | viability | GCAGCTCCGTCAGTCCCGCCGGG | PRKAR2B | ENSG00000005249 | -0.4594316186372973 | [6] | [8] | -4 | hSpCas9 | negative selection | 10725145 | 107044980 | 107045003 | 7 | - | 28162770 | SKM1 | viability | GCGAACTCCAGCAGGTCCGCGGG | PRKAR2B | ENSG00000005249 | -0.7207183621848239 | [54] | [58] | -5 | hSpCas9 | negative selection | 10725146 | 107044907 | 107044930 | 7 | + | 28162770 | PL21 | viability | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 0.035080368218823876 | [147] | [65] | 0 | hSpCas9 | negative selection | 10894503 | 107146336 | 107146359 | 7 | + | 28162770 | PL21 | viability | GATGGTGTTGGAAGATGTGTTGG | PRKAR2B | ENSG00000005249 | 0.5576916191074037 | [511] | [327] | 5 | hSpCas9 | negative selection | 10894504 | 107044940 | 107044963 | 7 | + | 28162770 | PL21 | viability | GCTGCTGCAGGGCTTCACGGTGG | PRKAR2B | ENSG00000005249 | 0.22151326528188703 | [133] | [67] | 2 | hSpCas9 | negative selection | 10894505 | 107045153 | 107045176 | 7 | + | 28162770 | PL21 | viability | GTCCGACTCCGAGGACGGGGAGG | PRKAR2B | ENSG00000005249 | 1.110872276392233 | [49] | [46] | 8 | hSpCas9 | negative selection | 10894506 | 107044964 | 107044987 | 7 | + | 28162770 | PL21 | viability | GGTGCTGAGGCACCAGCCCGCGG | PRKAR2B | ENSG00000005249 | 1.5562834247145954 | [24] | [31] | 9 | hSpCas9 | negative selection | 10894507 | 107140907 | 107140930 | 7 | + | 28162770 | PL21 | viability | GTAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | -0.2577836976426999 | [238] | [86] | -2 | hSpCas9 | negative selection | 10894508 | 107153210 | 107153233 | 7 | + | 28162770 | PL21 | viability | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -0.108810626399832 | [165] | [66] | -1 | hSpCas9 | negative selection | 10894509 | 107157296 | 107157319 | 7 | - | 28162770 | PL21 | viability | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -0.0431315365230438 | [115] | [48] | 0 | hSpCas9 | negative selection | 10894510 | 107044922 | 107044945 | 7 | - | 28162770 | PL21 | viability | GCAGCTCCGTCAGTCCCGCCGGG | PRKAR2B | ENSG00000005249 | 1.2001396144893204 | [8] | [8] | 8 | hSpCas9 | negative selection | 10894511 | 107044980 | 107045003 | 7 | - | 28162770 | PL21 | viability | GCGAACTCCAGCAGGTCCGCGGG | PRKAR2B | ENSG00000005249 | -0.4917380901483481 | [209] | [64] | -4 | hSpCas9 | negative selection | 10894512 | 107044907 | 107044930 | 7 | + | 28162770 | P31FUJ | viability | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 0.6203564072563503 | [123] | [223] | 7 | hSpCas9 | negative selection | 11063869 | 107146336 | 107146359 | 7 | + | 28162770 | P31FUJ | viability | GATGGTGTTGGAAGATGTGTTGG | PRKAR2B | ENSG00000005249 | 0.36608725434885514 | [755] | [1144] | 4 | hSpCas9 | negative selection | 11063870 | 107044940 | 107044963 | 7 | + | 28162770 | P31FUJ | viability | GCTGCTGCAGGGCTTCACGGTGG | PRKAR2B | ENSG00000005249 | 0.32749824207250844 | [117] | [173] | 3 | hSpCas9 | negative selection | 11063871 | 107045153 | 107045176 | 7 | + | 28162770 | P31FUJ | viability | GTCCGACTCCGAGGACGGGGAGG | PRKAR2B | ENSG00000005249 | -0.30151495449839283 | [85] | [81] | -3 | hSpCas9 | negative selection | 11063872 | 107044964 | 107044987 | 7 | + | 28162770 | P31FUJ | viability | GGTGCTGAGGCACCAGCCCGCGG | PRKAR2B | ENSG00000005249 | -0.6478397036932222 | [31] | [23] | -5 | hSpCas9 | negative selection | 11063873 | 107140907 | 107140930 | 7 | + | 28162770 | P31FUJ | viability | GTAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | 0.473466592528911 | [246] | [402] | 5 | hSpCas9 | negative selection | 11063874 | 107153210 | 107153233 | 7 | + | 28162770 | P31FUJ | viability | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -0.5400835233373397 | [244] | [197] | -4 | hSpCas9 | negative selection | 11063875 | 107157296 | 107157319 | 7 | - | 28162770 | P31FUJ | viability | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -0.6343185640396036 | [176] | [133] | -5 | hSpCas9 | negative selection | 11063876 | 107044922 | 107044945 | 7 | - | 28162770 | P31FUJ | viability | GCAGCTCCGTCAGTCCCGCCGGG | PRKAR2B | ENSG00000005249 | -0.20680699588143447 | [54] | [55] | -2 | hSpCas9 | negative selection | 11063877 | 107044980 | 107045003 | 7 | - | 28162770 | P31FUJ | viability | GCGAACTCCAGCAGGTCCGCGGG | PRKAR2B | ENSG00000005249 | 0.33879307256894875 | [252] | [375] | 4 | hSpCas9 | negative selection | 11063878 | 107044907 | 107044930 | 7 | + | 28162770 | OCIAML5 | viability | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 1.0098572937330303 | [62] | [228] | 8 | hSpCas9 | negative selection | 11233235 | 107146336 | 107146359 | 7 | + | 28162770 | OCIAML5 | viability | GATGGTGTTGGAAGATGTGTTGG | PRKAR2B | ENSG00000005249 | 0.2808545402216396 | [429] | [942] | 2 | hSpCas9 | negative selection | 11233236 | 107044940 | 107044963 | 7 | + | 28162770 | OCIAML5 | viability | GCTGCTGCAGGGCTTCACGGTGG | PRKAR2B | ENSG00000005249 | -0.1216736306212769 | [43] | [72] | -1 | hSpCas9 | negative selection | 11233237 | 107045153 | 107045176 | 7 | + | 28162770 | OCIAML5 | viability | GTCCGACTCCGAGGACGGGGAGG | PRKAR2B | ENSG00000005249 | -0.12858420606141285 | [42] | [70] | -1 | hSpCas9 | negative selection | 11233238 | 107044964 | 107044987 | 7 | + | 28162770 | OCIAML5 | viability | GGTGCTGAGGCACCAGCCCGCGG | PRKAR2B | ENSG00000005249 | 1.8584268119410179 | [10] | [71] | 9 | hSpCas9 | negative selection | 11233239 | 107140907 | 107140930 | 7 | + | 28162770 | OCIAML5 | viability | GTAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | 0.7665463192990761 | [112] | [346] | 6 | hSpCas9 | negative selection | 11233240 | 107153210 | 107153233 | 7 | + | 28162770 | OCIAML5 | viability | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | 0.2501569377277928 | [142] | [306] | 2 | hSpCas9 | negative selection | 11233241 | 107157296 | 107157319 | 7 | - | 28162770 | OCIAML5 | viability | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -0.388666050023754 | [65] | [90] | -3 | hSpCas9 | negative selection | 11233242 | 107044922 | 107044945 | 7 | - | 28162770 | OCIAML5 | viability | GCAGCTCCGTCAGTCCCGCCGGG | PRKAR2B | ENSG00000005249 | 0.767790720303345 | [176] | [543] | 6 | hSpCas9 | negative selection | 11233243 | 107044980 | 107045003 | 7 | - | 28162770 | OCIAML5 | viability | GCGAACTCCAGCAGGTCCGCGGG | PRKAR2B | ENSG00000005249 | -0.360886216463458 | [142] | [200] | -3 | hSpCas9 | negative selection | 11233244 | 107044907 | 107044930 | 7 | + | 28162770 | EOL1 | viability | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 0.5095102722916908 | [235] | [176] | 4 | hSpCas9 | negative selection | 11402601 | 107146336 | 107146359 | 7 | + | 28162770 | EOL1 | viability | GATGGTGTTGGAAGATGTGTTGG | PRKAR2B | ENSG00000005249 | 1.131519148742674 | [738] | [852] | 8 | hSpCas9 | negative selection | 11402602 | 107044940 | 107044963 | 7 | + | 28162770 | EOL1 | viability | GCTGCTGCAGGGCTTCACGGTGG | PRKAR2B | ENSG00000005249 | -0.49048972770830934 | [143] | [53] | -4 | hSpCas9 | negative selection | 11402603 | 107045153 | 107045176 | 7 | + | 28162770 | EOL1 | viability | GTCCGACTCCGAGGACGGGGAGG | PRKAR2B | ENSG00000005249 | -0.12889148739092593 | [109] | [52] | -1 | hSpCas9 | negative selection | 11402604 | 107044964 | 107044987 | 7 | + | 28162770 | EOL1 | viability | GGTGCTGAGGCACCAGCCCGCGG | PRKAR2B | ENSG00000005249 | 1.5893635799809054 | [40] | [64] | 9 | hSpCas9 | negative selection | 11402605 | 107140907 | 107140930 | 7 | + | 28162770 | EOL1 | viability | GTAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | -0.2719749420847631 | [478] | [208] | -2 | hSpCas9 | negative selection | 11402606 | 107153210 | 107153233 | 7 | + | 28162770 | EOL1 | viability | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | 1.0102776455964184 | [293] | [311] | 8 | hSpCas9 | negative selection | 11402607 | 107157296 | 107157319 | 7 | - | 28162770 | EOL1 | viability | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | 0.11719284951293041 | [111] | [63] | 1 | hSpCas9 | negative selection | 11402608 | 107044922 | 107044945 | 7 | - | 28162770 | EOL1 | viability | GCAGCTCCGTCAGTCCCGCCGGG | PRKAR2B | ENSG00000005249 | 0.3470027424118616 | [96] | [64] | 3 | hSpCas9 | negative selection | 11402609 | 107044980 | 107045003 | 7 | - | 28162770 | EOL1 | viability | GCGAACTCCAGCAGGTCCGCGGG | PRKAR2B | ENSG00000005249 | 0.6253586009782105 | [298] | [242] | 5 | hSpCas9 | negative selection | 11402610 | 107044907 | 107044930 | 7 | + | 28162770 | MOLM13 | viability | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 0.7733023896489244 | [245] | [303] | 6 | hSpCas9 | negative selection | 11571967 | 107146336 | 107146359 | 7 | + | 28162770 | MOLM13 | viability | GATGGTGTTGGAAGATGTGTTGG | PRKAR2B | ENSG00000005249 | 0.5691188563360059 | [907] | [973] | 4 | hSpCas9 | negative selection | 11571968 | 107044940 | 107044963 | 7 | + | 28162770 | MOLM13 | viability | GCTGCTGCAGGGCTTCACGGTGG | PRKAR2B | ENSG00000005249 | 1.3878672981133737 | [138] | [262] | 9 | hSpCas9 | negative selection | 11571969 | 107045153 | 107045176 | 7 | + | 28162770 | MOLM13 | viability | GTCCGACTCCGAGGACGGGGAGG | PRKAR2B | ENSG00000005249 | -0.0932263772222095 | [89] | [60] | 0 | hSpCas9 | negative selection | 11571970 | 107044964 | 107044987 | 7 | + | 28162770 | MOLM13 | viability | GGTGCTGAGGCACCAGCCCGCGG | PRKAR2B | ENSG00000005249 | 0.9703897220737621 | [59] | [84] | 7 | hSpCas9 | negative selection | 11571971 | 107140907 | 107140930 | 7 | + | 28162770 | MOLM13 | viability | GTAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | 0.5909002716499222 | [381] | [415] | 4 | hSpCas9 | negative selection | 11571972 | 107153210 | 107153233 | 7 | + | 28162770 | MOLM13 | viability | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -1.363052360830641 | [369] | [103] | -6 | hSpCas9 | negative selection | 11571973 | 107157296 | 107157319 | 7 | - | 28162770 | MOLM13 | viability | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -0.9726832098414024 | [132] | [48] | -5 | hSpCas9 | negative selection | 11571974 | 107044922 | 107044945 | 7 | - | 28162770 | MOLM13 | viability | GCAGCTCCGTCAGTCCCGCCGGG | PRKAR2B | ENSG00000005249 | 0.5243498708045746 | [450] | [468] | 4 | hSpCas9 | negative selection | 11571975 | 107044980 | 107045003 | 7 | - | 28162770 | MOLM13 | viability | GCGAACTCCAGCAGGTCCGCGGG | PRKAR2B | ENSG00000005249 | 0.8432934213869925 | [285] | [370] | 6 | hSpCas9 | negative selection | 11571976 | 107044907 | 107044930 | 7 | + | 28162770 | HEL | viability | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 0.963258732494911 | [204] | [255] | 8 | hSpCas9 | negative selection | 11741333 | 107146336 | 107146359 | 7 | + | 28162770 | HEL | viability | GATGGTGTTGGAAGATGTGTTGG | PRKAR2B | ENSG00000005249 | -0.06321405784903411 | [720] | [441] | 0 | hSpCas9 | negative selection | 11741334 | 107044940 | 107044963 | 7 | + | 28162770 | HEL | viability | GCTGCTGCAGGGCTTCACGGTGG | PRKAR2B | ENSG00000005249 | 0.6809581542308473 | [148] | [152] | 6 | hSpCas9 | negative selection | 11741335 | 107045153 | 107045176 | 7 | + | 28162770 | HEL | viability | GTCCGACTCCGAGGACGGGGAGG | PRKAR2B | ENSG00000005249 | 0.45632570776947545 | [98] | [86] | 4 | hSpCas9 | negative selection | 11741336 | 107044964 | 107044987 | 7 | + | 28162770 | HEL | viability | GGTGCTGAGGCACCAGCCCGCGG | PRKAR2B | ENSG00000005249 | -1.472738385419579 | [25] | [5] | -7 | hSpCas9 | negative selection | 11741337 | 107140907 | 107140930 | 7 | + | 28162770 | HEL | viability | GTAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | 0.6470261904034551 | [335] | [336] | 5 | hSpCas9 | negative selection | 11741338 | 107153210 | 107153233 | 7 | + | 28162770 | HEL | viability | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -0.4019609754704572 | [294] | [142] | -3 | hSpCas9 | negative selection | 11741339 | 107157296 | 107157319 | 7 | - | 28162770 | HEL | viability | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | 0.6819094292810346 | [108] | [111] | 6 | hSpCas9 | negative selection | 11741340 | 107044922 | 107044945 | 7 | - | 28162770 | HEL | viability | GCAGCTCCGTCAGTCCCGCCGGG | PRKAR2B | ENSG00000005249 | 0.3227228580567717 | [376] | [301] | 2 | hSpCas9 | negative selection | 11741341 | 107044980 | 107045003 | 7 | - | 28162770 | HEL | viability | GCGAACTCCAGCAGGTCCGCGGG | PRKAR2B | ENSG00000005249 | -0.6877343720200142 | [253] | [100] | -4 | hSpCas9 | negative selection | 11741342 | 107044907 | 107044930 | 7 | + | 28162770 | MV411 | viability | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 0.8324000515039316 | [149] | [224] | 7 | hSpCas9 | negative selection | 11910699 | 107146336 | 107146359 | 7 | + | 28162770 | MV411 | viability | GATGGTGTTGGAAGATGTGTTGG | PRKAR2B | ENSG00000005249 | 0.5946462949805058 | [576] | [733] | 5 | hSpCas9 | negative selection | 11910700 | 107044940 | 107044963 | 7 | + | 28162770 | MV411 | viability | GCTGCTGCAGGGCTTCACGGTGG | PRKAR2B | ENSG00000005249 | 0.7238755947257625 | [91] | [127] | 6 | hSpCas9 | negative selection | 11910701 | 107045153 | 107045176 | 7 | + | 28162770 | MV411 | viability | GTCCGACTCCGAGGACGGGGAGG | PRKAR2B | ENSG00000005249 | 1.8736227142304445 | [45] | [141] | 9 | hSpCas9 | negative selection | 11910702 | 107044964 | 107044987 | 7 | + | 28162770 | MV411 | viability | GGTGCTGAGGCACCAGCCCGCGG | PRKAR2B | ENSG00000005249 | 0.6780719051126378 | [22] | [30] | 6 | hSpCas9 | negative selection | 11910703 | 107140907 | 107140930 | 7 | + | 28162770 | MV411 | viability | GTAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | 1.1890733882687867 | [226] | [435] | 9 | hSpCas9 | negative selection | 11910704 | 107153210 | 107153233 | 7 | + | 28162770 | MV411 | viability | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -0.002969246723269158 | [181] | [152] | 0 | hSpCas9 | negative selection | 11910705 | 107157296 | 107157319 | 7 | - | 28162770 | MV411 | viability | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | -0.9845091772669214 | [100] | [42] | -6 | hSpCas9 | negative selection | 11910706 | 107044922 | 107044945 | 7 | - | 28162770 | MV411 | viability | GCAGCTCCGTCAGTCCCGCCGGG | PRKAR2B | ENSG00000005249 | 0.4921711398736253 | [118] | [140] | 4 | hSpCas9 | negative selection | 11910707 | 107044980 | 107045003 | 7 | - | 28162770 | MV411 | viability | GCGAACTCCAGCAGGTCCGCGGG | PRKAR2B | ENSG00000005249 | 0.6976032734652211 | [212] | [290] | 6 | hSpCas9 | negative selection | 11910708 | 107044907 | 107044930 | 7 | + | 28162770 | MONOMAC1 | viability | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 0.7745813515706241 | [76] | [150] | 7 | hSpCas9 | negative selection | 12080065 | 107146336 | 107146359 | 7 | + | 28162770 | MONOMAC1 | viability | GATGGTGTTGGAAGATGTGTTGG | PRKAR2B | ENSG00000005249 | 0.24722079113428386 | [390] | [531] | 2 | hSpCas9 | negative selection | 12080066 | 107044940 | 107044963 | 7 | + | 28162770 | MONOMAC1 | viability | GCTGCTGCAGGGCTTCACGGTGG | PRKAR2B | ENSG00000005249 | -0.28584611401740956 | [66] | [62] | -3 | hSpCas9 | negative selection | 12080067 | 107045153 | 107045176 | 7 | + | 28162770 | MONOMAC1 | viability | GTCCGACTCCGAGGACGGGGAGG | PRKAR2B | ENSG00000005249 | 0.0966943559971567 | [61] | [75] | 1 | hSpCas9 | negative selection | 12080068 | 107044964 | 107044987 | 7 | + | 28162770 | MONOMAC1 | viability | GGTGCTGAGGCACCAGCCCGCGG | PRKAR2B | ENSG00000005249 | -0.9340024412257599 | [19] | [11] | -6 | hSpCas9 | negative selection | 12080069 | 107140907 | 107140930 | 7 | + | 28162770 | MONOMAC1 | viability | GTAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | -1.0178122848794793 | [188] | [106] | -7 | hSpCas9 | negative selection | 12080070 | 107153210 | 107153233 | 7 | + | 28162770 | MONOMAC1 | viability | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | 0.26454323815632036 | [121] | [167] | 2 | hSpCas9 | negative selection | 12080071 | 107157296 | 107157319 | 7 | - | 28162770 | MONOMAC1 | viability | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | 0.7220431575568789 | [54] | [103] | 7 | hSpCas9 | negative selection | 12080072 | 107044922 | 107044945 | 7 | - | 28162770 | MONOMAC1 | viability | GCAGCTCCGTCAGTCCCGCCGGG | PRKAR2B | ENSG00000005249 | 0.5805707316039985 | [6] | [11] | 5 | hSpCas9 | negative selection | 12080073 | 107044980 | 107045003 | 7 | - | 28162770 | MONOMAC1 | viability | GCGAACTCCAGCAGGTCCGCGGG | PRKAR2B | ENSG00000005249 | 0.3498576128280828 | [127] | [186] | 3 | hSpCas9 | negative selection | 12080074 | 107044907 | 107044930 | 7 | + | 28162770 | OCIAML2 | viability | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | 0.2743285596775755 | [26] | [180] | 2 | hSpCas9 | negative selection | 12249431 | 107146336 | 107146359 | 7 | + | 28162770 | OCIAML2 | viability | GATGGTGTTGGAAGATGTGTTGG | PRKAR2B | ENSG00000005249 | 0.7883670139187442 | [81] | [784] | 7 | hSpCas9 | negative selection | 12249432 | 107044940 | 107044963 | 7 | + | 28162770 | OCIAML2 | viability | GCTGCTGCAGGGCTTCACGGTGG | PRKAR2B | ENSG00000005249 | 0.22980989289893106 | [15] | [103] | 2 | hSpCas9 | negative selection | 12249433 | 107045153 | 107045176 | 7 | + | 28162770 | OCIAML2 | viability | GTCCGACTCCGAGGACGGGGAGG | PRKAR2B | ENSG00000005249 | -0.044365070540063334 | [15] | [85] | 0 | hSpCas9 | negative selection | 12249434 | 107044964 | 107044987 | 7 | + | 28162770 | OCIAML2 | viability | GGTGCTGAGGCACCAGCCCGCGG | PRKAR2B | ENSG00000005249 | 0.22980989289893117 | [5] | [38] | 2 | hSpCas9 | negative selection | 12249435 | 107140907 | 107140930 | 7 | + | 28162770 | OCIAML2 | viability | GTAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | 0.33672509681544305 | [52] | [370] | 3 | hSpCas9 | negative selection | 12249436 | 107153210 | 107153233 | 7 | + | 28162770 | OCIAML2 | viability | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -0.8157653112908487 | [46] | [147] | -5 | hSpCas9 | negative selection | 12249437 | 107157296 | 107157319 | 7 | - | 28162770 | OCIAML2 | viability | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | 0.5371896792171381 | [22] | [184] | 5 | hSpCas9 | negative selection | 12249438 | 107044922 | 107044945 | 7 | - | 28162770 | OCIAML2 | viability | GCAGCTCCGTCAGTCCCGCCGGG | PRKAR2B | ENSG00000005249 | 0.38735116988541085 | [3] | [28] | 4 | hSpCas9 | negative selection | 12249439 | 107044980 | 107045003 | 7 | - | 28162770 | OCIAML2 | viability | GCGAACTCCAGCAGGTCCGCGGG | PRKAR2B | ENSG00000005249 | 0.28425767692130743 | [31] | [215] | 2 | hSpCas9 | negative selection | 12249440 | 107044907 | 107044930 | 7 | + | 28162770 | OCIAML3 | viability | GATGAGCATCGAGATCCCGGCGG | PRKAR2B | ENSG00000005249 | -0.7056529961530724 | [46] | [86] | -5 | hSpCas9 | negative selection | 12418797 | 107146336 | 107146359 | 7 | + | 28162770 | OCIAML3 | viability | GATGGTGTTGGAAGATGTGTTGG | PRKAR2B | ENSG00000005249 | 0.2122447252862829 | [186] | [653] | 2 | hSpCas9 | negative selection | 12418798 | 107044940 | 107044963 | 7 | + | 28162770 | OCIAML3 | viability | GCTGCTGCAGGGCTTCACGGTGG | PRKAR2B | ENSG00000005249 | -0.9095094660520925 | [27] | [44] | -6 | hSpCas9 | negative selection | 12418799 | 107045153 | 107045176 | 7 | + | 28162770 | OCIAML3 | viability | GTCCGACTCCGAGGACGGGGAGG | PRKAR2B | ENSG00000005249 | 0.5689309308020423 | [22] | [102] | 5 | hSpCas9 | negative selection | 12418800 | 107044964 | 107044987 | 7 | + | 28162770 | OCIAML3 | viability | GGTGCTGAGGCACCAGCCCGCGG | PRKAR2B | ENSG00000005249 | -0.33097323449036953 | [9] | [23] | -3 | hSpCas9 | negative selection | 12418801 | 107140907 | 107140930 | 7 | + | 28162770 | OCIAML3 | viability | GTAATTGATCAAGGTGACGATGG | PRKAR2B | ENSG00000005249 | -0.43301576365185834 | [71] | [160] | -3 | hSpCas9 | negative selection | 12418802 | 107153210 | 107153233 | 7 | + | 28162770 | OCIAML3 | viability | GGCACCAAAGTATACAACGATGG | PRKAR2B | ENSG00000005249 | -1.5940076403241632 | [46] | [46] | -8 | hSpCas9 | negative selection | 12418803 | 107157296 | 107157319 | 7 | - | 28162770 | OCIAML3 | viability | ATTTGACAGTCCCAATGGCGTGG | PRKAR2B | ENSG00000005249 | 2.174666813569381 | [26] | [367] | 9 | hSpCas9 | negative selection | 12418804 | 107044922 | 107044945 | 7 | - | 28162770 | OCIAML3 | viability | GCAGCTCCGTCAGTCCCGCCGGG | PRKAR2B | ENSG00000005249 | -0.231437560939455 | [6] | [17] | -2 | hSpCas9 | negative selection | 12418805 | 107044980 | 107045003 | 7 | - | 28162770 | OCIAML3 | viability | GCGAACTCCAGCAGGTCCGCGGG | PRKAR2B | ENSG00000005249 | -0.2832201030420012 | [51] | [128] | -2 | hSpCas9 | negative selection | 12418806 |