Crispr

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:378951
  • Symbol:RBMY1J
  • Description:RNA binding motif protein Y-linked family 1 member J
DataSource: http://genomecrispr.dkfz.de/#!/results/RBMY1J

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Start The end chr strand pubmed cellline condition sequence symbol ensg log2fc rc_initial rc_final effect cas screentype index
22409308 22409331 Y - 26472758 Jiyoye viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 -0.02189817745983147 [722] [536] 0 hSpCas9 negative selection 134734
22409300 22409323 Y + 26472758 Jiyoye viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 0.6144079956713158 [245] [283] 4 hSpCas9 negative selection 134749
22417505 22417528 Y - 26472758 Jiyoye viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 0.5117059649771803 [172] [185] 4 hSpCas9 negative selection 134774
22417347 22417370 Y - 26472758 Jiyoye viability GTGGCAGGTGCTTCCACCATAAG RBMY1J ENSG00000226941 0.018133090759974158 [384] [293] 0 hSpCas9 negative selection 134788
22417347 22417370 Y - 26472758 Jiyoye viability GTGGCAGGTGCTTCCACCATAAG RBMY1J ENSG00000226941 0.018133090759974158 [384] [293] 0 hSpCas9 negative selection 134822
22409308 22409331 Y - 26472758 Jiyoye viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 -0.02189817745983147 [722] [536] 0 hSpCas9 negative selection 134848
22409282 22409305 Y + 26472758 Jiyoye viability GCAGTGGAGGAACAAGAGGGTGG RBMY1J ENSG00000226941 -1.474768856972414 [128] [34] -7 hSpCas9 negative selection 134852
22409300 22409323 Y + 26472758 Jiyoye viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 0.6144079956713158 [245] [283] 4 hSpCas9 negative selection 134853
22417505 22417528 Y - 26472758 Jiyoye viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 0.5117059649771803 [172] [185] 4 hSpCas9 negative selection 134857
22409308 22409331 Y - 26472758 Jiyoye viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 -0.02189817745983147 [722] [536] 0 hSpCas9 negative selection 134861
22409282 22409305 Y + 26472758 Jiyoye viability GCAGTGGAGGAACAAGAGGGTGG RBMY1J ENSG00000226941 -1.474768856972414 [128] [34] -7 hSpCas9 negative selection 134862
22409300 22409323 Y + 26472758 Jiyoye viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 0.6144079956713158 [245] [283] 4 hSpCas9 negative selection 134864
22417505 22417528 Y - 26472758 Jiyoye viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 0.5117059649771803 [172] [185] 4 hSpCas9 negative selection 134867
22409308 22409331 Y - 26472758 KBM7 viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 0.48309613408595764 [2537,1750] [1346,1427] 5 hSpCas9 negative selection 325852
22409300 22409323 Y + 26472758 KBM7 viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 0.7113373718883016 [1563,952] [1241,687] 7 hSpCas9 negative selection 325867
22417505 22417528 Y - 26472758 KBM7 viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 0.677503011107895 [410,469] [341,328] 7 hSpCas9 negative selection 325892
22417347 22417370 Y - 26472758 KBM7 viability GTGGCAGGTGCTTCCACCATAAG RBMY1J ENSG00000226941 0.7215404418410358 [1862,1911] [1359,1572] 7 hSpCas9 negative selection 325906
22417347 22417370 Y - 26472758 KBM7 viability GTGGCAGGTGCTTCCACCATAAG RBMY1J ENSG00000226941 0.7215404418410358 [1862,1911] [1359,1572] 7 hSpCas9 negative selection 325940
22409308 22409331 Y - 26472758 KBM7 viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 0.48309613408595764 [2537,1750] [1346,1427] 5 hSpCas9 negative selection 325966
22409282 22409305 Y + 26472758 KBM7 viability GCAGTGGAGGAACAAGAGGGTGG RBMY1J ENSG00000226941 -1.3975362689965731 [735,511] [102,115] -7 hSpCas9 negative selection 325970
22409300 22409323 Y + 26472758 KBM7 viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 0.7113373718883016 [1563,952] [1241,687] 7 hSpCas9 negative selection 325971
22417505 22417528 Y - 26472758 KBM7 viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 0.677503011107895 [410,469] [341,328] 7 hSpCas9 negative selection 325975
22409308 22409331 Y - 26472758 KBM7 viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 0.48309613408595764 [2537,1750] [1346,1427] 5 hSpCas9 negative selection 325979
22409282 22409305 Y + 26472758 KBM7 viability GCAGTGGAGGAACAAGAGGGTGG RBMY1J ENSG00000226941 -1.3975362689965731 [735,511] [102,115] -7 hSpCas9 negative selection 325980
22409300 22409323 Y + 26472758 KBM7 viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 0.7113373718883016 [1563,952] [1241,687] 7 hSpCas9 negative selection 325982
22417505 22417528 Y - 26472758 KBM7 viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 0.677503011107895 [410,469] [341,328] 7 hSpCas9 negative selection 325985
22409308 22409331 Y - 26472758 Raji viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 0.5528783254643068 [1077] [366] 5 hSpCas9 negative selection 516970
22409300 22409323 Y + 26472758 Raji viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 0.19814899929678198 [615] [163] 1 hSpCas9 negative selection 516985
22417505 22417528 Y - 26472758 Raji viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 0.872554010798929 [232] [98] 7 hSpCas9 negative selection 517010
22417347 22417370 Y - 26472758 Raji viability GTGGCAGGTGCTTCCACCATAAG RBMY1J ENSG00000226941 0.16572752160440452 [944] [245] 1 hSpCas9 negative selection 517024
22417347 22417370 Y - 26472758 Raji viability GTGGCAGGTGCTTCCACCATAAG RBMY1J ENSG00000226941 0.16572752160440452 [944] [245] 1 hSpCas9 negative selection 517058
22409308 22409331 Y - 26472758 Raji viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 0.5528783254643068 [1077] [366] 5 hSpCas9 negative selection 517084
22409282 22409305 Y + 26472758 Raji viability GCAGTGGAGGAACAAGAGGGTGG RBMY1J ENSG00000226941 -2.082441023506418 [291] [15] -8 hSpCas9 negative selection 517088
22409300 22409323 Y + 26472758 Raji viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 0.19814899929678198 [615] [163] 1 hSpCas9 negative selection 517089
22417505 22417528 Y - 26472758 Raji viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 0.872554010798929 [232] [98] 7 hSpCas9 negative selection 517093
22409308 22409331 Y - 26472758 Raji viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 0.5528783254643068 [1077] [366] 5 hSpCas9 negative selection 517097
22409282 22409305 Y + 26472758 Raji viability GCAGTGGAGGAACAAGAGGGTGG RBMY1J ENSG00000226941 -2.082441023506418 [291] [15] -8 hSpCas9 negative selection 517098
22409300 22409323 Y + 26472758 Raji viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 0.19814899929678198 [615] [163] 1 hSpCas9 negative selection 517100
22417505 22417528 Y - 26472758 Raji viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 0.872554010798929 [232] [98] 7 hSpCas9 negative selection 517103
22409308 22409331 Y - 26472758 K562 viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 1.2941252492854116 [1839] [3808] 9 hSpCas9 negative selection 708088
22409300 22409323 Y + 26472758 K562 viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 0.9491812097882677 [1050] [1712] 7 hSpCas9 negative selection 708103
22417505 22417528 Y - 26472758 K562 viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 1.0862370592922728 [389] [698] 8 hSpCas9 negative selection 708128
22417347 22417370 Y - 26472758 K562 viability GTGGCAGGTGCTTCCACCATAAG RBMY1J ENSG00000226941 1.062440574775907 [1231] [2171] 8 hSpCas9 negative selection 708142
22417347 22417370 Y - 26472758 K562 viability GTGGCAGGTGCTTCCACCATAAG RBMY1J ENSG00000226941 1.062440574775907 [1231] [2171] 8 hSpCas9 negative selection 708176
22409308 22409331 Y - 26472758 K562 viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 1.2941252492854116 [1839] [3808] 9 hSpCas9 negative selection 708202
22409282 22409305 Y + 26472758 K562 viability GCAGTGGAGGAACAAGAGGGTGG RBMY1J ENSG00000226941 -7.6443245212318125 [473] [1] -9 hSpCas9 negative selection 708206
22409300 22409323 Y + 26472758 K562 viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 0.9491812097882677 [1050] [1712] 7 hSpCas9 negative selection 708207
22417505 22417528 Y - 26472758 K562 viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 1.0862370592922728 [389] [698] 8 hSpCas9 negative selection 708211
22409308 22409331 Y - 26472758 K562 viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 1.2941252492854116 [1839] [3808] 9 hSpCas9 negative selection 708215
22409282 22409305 Y + 26472758 K562 viability GCAGTGGAGGAACAAGAGGGTGG RBMY1J ENSG00000226941 -7.6443245212318125 [473] [1] -9 hSpCas9 negative selection 708216
22409300 22409323 Y + 26472758 K562 viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 0.9491812097882677 [1050] [1712] 7 hSpCas9 negative selection 708218
22417505 22417528 Y - 26472758 K562 viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 1.0862370592922728 [389] [698] 8 hSpCas9 negative selection 708221
22403313 22403336 Y - 25494202 A375 resistance to PLX-4720 (puromycin) CCTGCGGCTCCATCATCTCGCGG RBMY1J ENSG00000226941 0.19594259435042893 [3668,2848] [1318,283] 0 dCas9-VP64 positive selection 2387955
22403280 22403303 Y - 25494202 A375 resistance to PLX-4720 (puromycin) GAGACCACGCTTGTGCCGCGTGG RBMY1J ENSG00000226941 0.051999586854684754 [205,210] [53,39] 0 dCas9-VP64 positive selection 2387957
22403336 22403359 Y - 25494202 A375 resistance to PLX-4720 (puromycin) TGAGGCCGCTCCGCCCCAGCAGG RBMY1J ENSG00000226941 0.29286461804590314 [2028,1502] [580,360] 1 dCas9-VP64 positive selection 2387959
22403253 22403276 Y + 25494202 A375 resistance to PLX-4720 (puromycin) GCGTGTGCCTTAATCCACCGCGG RBMY1J ENSG00000226941 1.4247532467742168 [202,27] [104,25] 5 dCas9-VP64 positive selection 2387964
22379149 22379172 Y + 25494202 A375 resistance to PLX-4720 (puromycin) GCACTTTGGGAGGCAGAGACAGG RBMY1J ENSG00000226941 -0.1382628736712302 [122,32] [23,4] 0 dCas9-VP64 positive selection 2412950
22403313 22403336 Y - 25494202 A375 resistance to PLX-4720 (zeocin) CCTGCGGCTCCATCATCTCGCGG RBMY1J ENSG00000226941 2.7921081462190456 [2053,2440] [631,9250] 9 dCas9-VP64 positive selection 2483210
22403280 22403303 Y - 25494202 A375 resistance to PLX-4720 (zeocin) GAGACCACGCTTGTGCCGCGTGG RBMY1J ENSG00000226941 0.9068379278209089 [157,144] [92,92] 6 dCas9-VP64 positive selection 2483212
22403336 22403359 Y - 25494202 A375 resistance to PLX-4720 (zeocin) TGAGGCCGCTCCGCCCCAGCAGG RBMY1J ENSG00000226941 1.6407804011090934 [1386,1047] [700,1752] 8 dCas9-VP64 positive selection 2483214
22403253 22403276 Y + 25494202 A375 resistance to PLX-4720 (zeocin) GCGTGTGCCTTAATCCACCGCGG RBMY1J ENSG00000226941 0.31012865395691436 [327,373] [183,101] 2 dCas9-VP64 positive selection 2483219
22379149 22379172 Y + 25494202 A375 resistance to PLX-4720 (zeocin) GCACTTTGGGAGGCAGAGACAGG RBMY1J ENSG00000226941 0.5826032865103569 [42,50] [25,19] 4 dCas9-VP64 positive selection 2508205
22409251 22409274 Y - 27383988 293T resistance to West Nile virus (flavivirus) GCAGATCTCAGACTTCCTGAAGG RBMY1J ENSG00000226941 -0.16052630344006283 [170,170] [0,0] -1 hSpCas9 positive selection 3389297
22406086 22406109 Y - 26780180 HT29 viability (Avana library 4 designs) CAGCATTCTTAGCATCTGCAGGG RBMY1J ENSG00000226941 -0.831542001986951 [] [] -9 hSpCas9 negative selection 3454383
22406039 22406062 Y + 26780180 HT29 viability (Avana library 4 designs) GATCGAACCAGCAAATCCAGAGG RBMY1J ENSG00000226941 0.405995780617219 [] [] 1 hSpCas9 negative selection 3454384
22406039 22406062 Y + 26780180 HT29 viability (Avana library 4 designs) GATCGAACCAGCAAATCCAGAGG RBMY1J ENSG00000226941 0.405995780617219 [] [] 1 hSpCas9 negative selection 3454385
22409251 22409274 Y - 26780180 HT29 viability (Avana library 4 designs) GCAGATCTCAGACTTCCTGAAGG RBMY1J ENSG00000226941 -0.777094246521086 [] [] -9 hSpCas9 negative selection 3454386
22409257 22409280 Y + 26780180 HT29 viability (Avana library 4 designs) GGAAGTCTGAGATCTGCAAGAGG RBMY1J ENSG00000226941 -0.818812298300143 [] [] -9 hSpCas9 negative selection 3454387
22406086 22406109 Y - 26780180 A375 viability (Avana lentiCRISPRv2) CAGCATTCTTAGCATCTGCAGGG RBMY1J ENSG00000226941 2.42954907605902 [] [] 3 hSpCas9 negative selection 3551718
22409257 22409280 Y + 26780180 A375 viability (Avana lentiCRISPRv2) GGAAGTCTGAGATCTGCAAGAGG RBMY1J ENSG00000226941 5.57212247559054 [] [] 8 hSpCas9 negative selection 3551719
22409251 22409274 Y - 26780180 A375 viability (Avana lentiCRISPRv2) GCAGATCTCAGACTTCCTGAAGG RBMY1J ENSG00000226941 0.682149486527698 [] [] 0 hSpCas9 negative selection 3551720
22406039 22406062 Y + 26780180 A375 viability (Avana lentiCRISPRv2) GATCGAACCAGCAAATCCAGAGG RBMY1J ENSG00000226941 0.244999387163261 [] [] 0 hSpCas9 negative selection 3551721
22406039 22406062 Y + 26780180 A375 viability (Avana lentiCRISPRv2) GATCGAACCAGCAAATCCAGAGG RBMY1J ENSG00000226941 0.244999387163261 [] [] 0 hSpCas9 negative selection 3551722
22406039 22406062 Y + 26780180 A375 viability (Avana lentiCRISPRv2) GATCGAACCAGCAAATCCAGAGG RBMY1J ENSG00000226941 0.206596802845074 [] [] 0 hSpCas9 negative selection 3551723
22406039 22406062 Y + 26780180 A375 viability (Avana lentiCRISPRv2) GATCGAACCAGCAAATCCAGAGG RBMY1J ENSG00000226941 0.206596802845074 [] [] 0 hSpCas9 negative selection 3551724
22414484 22414507 Y + 26780180 A375 viability (Avana lentiCRISPRv2) TCCAAGTTGCCAAGAAACGAGGG RBMY1J ENSG00000226941 3.77162907303048 [] [] 6 hSpCas9 negative selection 3551725
22414484 22414507 Y + 26780180 A375 viability (Avana lentiCRISPRv2) TCCAAGTTGCCAAGAAACGAGGG RBMY1J ENSG00000226941 3.77162907303048 [] [] 6 hSpCas9 negative selection 3551726
22414484 22414507 Y + 26780180 A375 viability (Avana lentiCRISPRv2) TCCAAGTTGCCAAGAAACGAGGG RBMY1J ENSG00000226941 4.93671140722852 [] [] 8 hSpCas9 negative selection 3551727
22414484 22414507 Y + 26780180 A375 viability (Avana lentiCRISPRv2) TCCAAGTTGCCAAGAAACGAGGG RBMY1J ENSG00000226941 4.93671140722852 [] [] 8 hSpCas9 negative selection 3551728
22409224 22409247 Y - 26780180 A375 viability (Avana lentiCRISPRv2) CTGTTTCTCGAAGAAGCTGGTGG RBMY1J ENSG00000226941 3.8327820928576 [] [] 6 hSpCas9 negative selection 3551729
22406086 22406109 Y - 26780180 A375 viability (Avana lentiGuide) CAGCATTCTTAGCATCTGCAGGG RBMY1J ENSG00000226941 -3.7087992134527 [] [] -6 hSpCas9 negative selection 3660377
22409257 22409280 Y + 26780180 A375 viability (Avana lentiGuide) GGAAGTCTGAGATCTGCAAGAGG RBMY1J ENSG00000226941 -5.62455787187856 [] [] -8 hSpCas9 negative selection 3660378
22409251 22409274 Y - 26780180 A375 viability (Avana lentiGuide) GCAGATCTCAGACTTCCTGAAGG RBMY1J ENSG00000226941 -4.81808248293297 [] [] -7 hSpCas9 negative selection 3660379
22406039 22406062 Y + 26780180 A375 viability (Avana lentiGuide) GATCGAACCAGCAAATCCAGAGG RBMY1J ENSG00000226941 -7.91750509712941 [] [] -9 hSpCas9 negative selection 3660380
22406039 22406062 Y + 26780180 A375 viability (Avana lentiGuide) GATCGAACCAGCAAATCCAGAGG RBMY1J ENSG00000226941 -7.91750509712941 [] [] -9 hSpCas9 negative selection 3660381
22406039 22406062 Y + 26780180 A375 viability (Avana lentiGuide) GATCGAACCAGCAAATCCAGAGG RBMY1J ENSG00000226941 -6.71556264311718 [] [] -9 hSpCas9 negative selection 3660382
22406039 22406062 Y + 26780180 A375 viability (Avana lentiGuide) GATCGAACCAGCAAATCCAGAGG RBMY1J ENSG00000226941 -6.71556264311718 [] [] -9 hSpCas9 negative selection 3660383
22414484 22414507 Y + 26780180 A375 viability (Avana lentiGuide) TCCAAGTTGCCAAGAAACGAGGG RBMY1J ENSG00000226941 -3.92251169628691 [] [] -6 hSpCas9 negative selection 3660384
22414484 22414507 Y + 26780180 A375 viability (Avana lentiGuide) TCCAAGTTGCCAAGAAACGAGGG RBMY1J ENSG00000226941 -3.92251169628691 [] [] -6 hSpCas9 negative selection 3660385
22414484 22414507 Y + 26780180 A375 viability (Avana lentiGuide) TCCAAGTTGCCAAGAAACGAGGG RBMY1J ENSG00000226941 -6.06518366933956 [] [] -8 hSpCas9 negative selection 3660386
22414484 22414507 Y + 26780180 A375 viability (Avana lentiGuide) TCCAAGTTGCCAAGAAACGAGGG RBMY1J ENSG00000226941 -6.06518366933956 [] [] -8 hSpCas9 negative selection 3660387
22409224 22409247 Y - 26780180 A375 viability (Avana lentiGuide) CTGTTTCTCGAAGAAGCTGGTGG RBMY1J ENSG00000226941 -7.68025693284367 [] [] -9 hSpCas9 negative selection 3660388
22406086 22406109 Y - 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) CAGCATTCTTAGCATCTGCAGGG RBMY1J ENSG00000226941 0.08654822621084635 [8] [9,8] 2 hSpCas9 positive selection 3768984
22409257 22409280 Y + 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) GGAAGTCTGAGATCTGCAAGAGG RBMY1J ENSG00000226941 0.19832253748449846 [8] [9,8] 5 hSpCas9 positive selection 3768985
22409251 22409274 Y - 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) GCAGATCTCAGACTTCCTGAAGG RBMY1J ENSG00000226941 0.012172068673351744 [8] [8,8] 0 hSpCas9 positive selection 3768986
22406039 22406062 Y + 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) GATCGAACCAGCAAATCCAGAGG RBMY1J ENSG00000226941 0.030857069359835815 [4] [4,4] 0 hSpCas9 positive selection 3768987
22406039 22406062 Y + 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) GATCGAACCAGCAAATCCAGAGG RBMY1J ENSG00000226941 0.030857069359835815 [6] [7,6] 0 hSpCas9 positive selection 3768988
22406039 22406062 Y + 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) GATCGAACCAGCAAATCCAGAGG RBMY1J ENSG00000226941 0.1379314983592589 [4] [4,4] 3 hSpCas9 positive selection 3768989
22406039 22406062 Y + 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) GATCGAACCAGCAAATCCAGAGG RBMY1J ENSG00000226941 0.1379314983592589 [6] [7,6] 3 hSpCas9 positive selection 3768990
22414484 22414507 Y + 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) TCCAAGTTGCCAAGAAACGAGGG RBMY1J ENSG00000226941 0.1379314983592589 [6] [7,7] 3 hSpCas9 positive selection 3768991
22414484 22414507 Y + 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) TCCAAGTTGCCAAGAAACGAGGG RBMY1J ENSG00000226941 0.1379314983592589 [7] [8,8] 3 hSpCas9 positive selection 3768992
22414484 22414507 Y + 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) TCCAAGTTGCCAAGAAACGAGGG RBMY1J ENSG00000226941 0.2651996440999021 [6] [7,7] 7 hSpCas9 positive selection 3768993
22409224 22409247 Y - 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) CTGTTTCTCGAAGAAGCTGGTGG RBMY1J ENSG00000226941 0.2651996440999021 [6] [7,8] 7 hSpCas9 positive selection 3768994
22414484 22414507 Y + 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) TCCAAGTTGCCAAGAAACGAGGG RBMY1J ENSG00000226941 0.2651996440999021 [7] [8,8] 7 hSpCas9 positive selection 3768995
22406086 22406109 Y - 26780180 A375 resistance to vemurafenib (Avana lentiGuide) CAGCATTCTTAGCATCTGCAGGG RBMY1J ENSG00000226941 0.3017160494576949 [8] [9,9] 8 hSpCas9 positive selection 3877591
22409257 22409280 Y + 26780180 A375 resistance to vemurafenib (Avana lentiGuide) GGAAGTCTGAGATCTGCAAGAGG RBMY1J ENSG00000226941 0.22247282469842167 [9] [10,8] 5 hSpCas9 positive selection 3877592
22409251 22409274 Y - 26780180 A375 resistance to vemurafenib (Avana lentiGuide) GCAGATCTCAGACTTCCTGAAGG RBMY1J ENSG00000226941 0.27501222429633676 [9] [9,9] 7 hSpCas9 positive selection 3877593
22406039 22406062 Y + 26780180 A375 resistance to vemurafenib (Avana lentiGuide) GATCGAACCAGCAAATCCAGAGG RBMY1J ENSG00000226941 0.40214594209895754 [4] [6,5] 9 hSpCas9 positive selection 3877594
22406039 22406062 Y + 26780180 A375 resistance to vemurafenib (Avana lentiGuide) GATCGAACCAGCAAATCCAGAGG RBMY1J ENSG00000226941 0.40214594209895754 [7] [8,8] 9 hSpCas9 positive selection 3877595
22406039 22406062 Y + 26780180 A375 resistance to vemurafenib (Avana lentiGuide) GATCGAACCAGCAAATCCAGAGG RBMY1J ENSG00000226941 0.37433258593870405 [4] [6,5] 9 hSpCas9 positive selection 3877596
22406039 22406062 Y + 26780180 A375 resistance to vemurafenib (Avana lentiGuide) GATCGAACCAGCAAATCCAGAGG RBMY1J ENSG00000226941 0.37433258593870405 [7] [8,8] 9 hSpCas9 positive selection 3877597
22414484 22414507 Y + 26780180 A375 resistance to vemurafenib (Avana lentiGuide) TCCAAGTTGCCAAGAAACGAGGG RBMY1J ENSG00000226941 0.37433258593870405 [7] [7,8] 9 hSpCas9 positive selection 3877598
22414484 22414507 Y + 26780180 A375 resistance to vemurafenib (Avana lentiGuide) TCCAAGTTGCCAAGAAACGAGGG RBMY1J ENSG00000226941 0.37433258593870405 [8] [9,8] 9 hSpCas9 positive selection 3877599
22414484 22414507 Y + 26780180 A375 resistance to vemurafenib (Avana lentiGuide) TCCAAGTTGCCAAGAAACGAGGG RBMY1J ENSG00000226941 0.38710044013218525 [7] [7,8] 9 hSpCas9 positive selection 3877600
22409224 22409247 Y - 26780180 A375 resistance to vemurafenib (Avana lentiGuide) CTGTTTCTCGAAGAAGCTGGTGG RBMY1J ENSG00000226941 0.38710044013218525 [5] [7,6] 9 hSpCas9 positive selection 3877601
22414484 22414507 Y + 26780180 A375 resistance to vemurafenib (Avana lentiGuide) TCCAAGTTGCCAAGAAACGAGGG RBMY1J ENSG00000226941 0.38710044013218525 [8] [9,8] 9 hSpCas9 positive selection 3877602
22406102 22406125 Y + 26780180 A375 resistance to vemurafenib (GeCKOv2 lentiGuide) AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.26709485726707516 [1] [1,0] 5 hSpCas9 positive selection 4294255
22406102 22406125 Y + 27260156 BXPC3 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.06480906986820045 [99] [57,87,123,182] 1 hSpCas9 negative selection 5566715
22406102 22406125 Y + 27260156 A673 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.37210381012893134 [99] [210,136,131,147] 8 hSpCas9 negative selection 5687966
22406102 22406125 Y + 27260156 A375 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.48190369389737997 [99] [204,164,133,149] 7 hSpCas9 negative selection 5809217
22406102 22406125 Y + 27260156 COLO741 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.023191774653368746 [99] [195,72,125] 0 hSpCas9 negative selection 5930468
22406102 22406125 Y + 27260156 CAL120 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 -0.932719419652599 [99] [106,38,55] -8 hSpCas9 negative selection 6051719
22406102 22406125 Y + 27260156 CADOES1 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.462935795028141 [99] [167,95,84,164] 7 hSpCas9 negative selection 6172970
22406102 22406125 Y + 27260156 EWS502 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.7848722882300574 [99] [174,179,86,294] 9 hSpCas9 negative selection 6294221
22406102 22406125 Y + 27260156 EW8 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 -0.7673676979077464 [99] [62,28,40,59] -8 hSpCas9 negative selection 6415472
22406102 22406125 Y + 27260156 CORL105 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.2677146042281269 [99] [156,138,144,123] 5 hSpCas9 negative selection 6536723
22406102 22406125 Y + 27260156 HS294T viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 -0.15952859389657803 [99] [41,20,35,39] -2 hSpCas9 negative selection 6657974
22406102 22406125 Y + 27260156 HCC44 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 -0.052603696905966224 [99] [129,99,114,94] -1 hSpCas9 negative selection 6779225
22406102 22406125 Y + 27260156 G402 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.5581412615056975 [99] [364,212,38,131] 7 hSpCas9 negative selection 6900476
22406102 22406125 Y + 27260156 L33 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 -0.09599693182479374 [99] [123,18,74,83] -2 hSpCas9 negative selection 7021727
22406102 22406125 Y + 27260156 K562 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.45469851913300263 [99] [88,112,188,94] 6 hSpCas9 negative selection 7142978
22406102 22406125 Y + 27260156 HT29 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.2063747480319824 [99] [103,183,141,131] 4 hSpCas9 negative selection 7264229
22406102 22406125 Y + 27260156 MHHES1 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.4902698175488829 [99] [180,159,112,173] 8 hSpCas9 negative selection 7385480
22406102 22406125 Y + 27260156 MEWO viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.47884240972049574 [99] [109,164,111] 8 hSpCas9 negative selection 7506731
22406102 22406125 Y + 27260156 LNCAPCLONEFGC viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 -1.154050438683739 [99] [31,37,32,58] -9 hSpCas9 negative selection 7627982
22406102 22406125 Y + 27260156 PANC0327 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.46777203280992286 [99] [52,273,39,98] 7 hSpCas9 negative selection 7749233
22406102 22406125 Y + 27260156 NCIH2009 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 -0.22353200516719163 [99] [168,93,105] -3 hSpCas9 negative selection 7870484
22406102 22406125 Y + 27260156 NCIH1373 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.6105582273394918 [99] [324,79,85,60] 6 hSpCas9 negative selection 7991735
22406102 22406125 Y + 27260156 PATU8902 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.11699987308666016 [99] [250,180,96,77] 1 hSpCas9 negative selection 8112986
22406102 22406125 Y + 27260156 PANC1 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.2755033253937593 [99] [84,139,93,102] 4 hSpCas9 negative selection 8234237
22406102 22406125 Y + 27260156 PANC0813 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.1652220736918597 [99] [142,128,146,109] 2 hSpCas9 negative selection 8355488
22406102 22406125 Y + 27260156 RDES viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.010289043179001034 [99] [70,88,191,124] 0 hSpCas9 negative selection 8476739
22406102 22406125 Y + 27260156 PC3 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 -0.20070002634120065 [99] [41,52,231,91] -4 hSpCas9 negative selection 8597990
22406102 22406125 Y + 27260156 PATU8988T viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.58580687407386 [99] [132,47,200,191] 8 hSpCas9 negative selection 8719241
22406102 22406125 Y + 27260156 T47D viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.3374128056783319 [99] [160,145,95,187] 7 hSpCas9 negative selection 8840492
22406102 22406125 Y + 27260156 SU8686 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.1630208017239605 [99] [132,112,104,84] 2 hSpCas9 negative selection 8961743
22406102 22406125 Y + 27260156 SKES1 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 -0.856595059850112 [99] [90,35,64,32] -9 hSpCas9 negative selection 9082994
22406102 22406125 Y + 27260156 TOV112D viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.596705073060307 [99] [161,304,124,54] 9 hSpCas9 negative selection 9204245
22406102 22406125 Y + 27260156 TC71 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.2514494801555307 [99] [126,109,83,194] 6 hSpCas9 negative selection 9325496
22406102 22406125 Y + 27260156 TC32 viability AATGCTGCGAAAGATATGAATGG RBMY1J ENSG00000226941 0.5336774683616876 [99] [168,66,189,141] 8 hSpCas9 negative selection 9446747
22409308 22409331 Y - 28162770 P31FUJ viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 0.5106443572123756 [843] [1412] 6 hSpCas9 negative selection 10223366
22409282 22409305 Y + 28162770 P31FUJ viability GCAGTGGAGGAACAAGAGGGTGG RBMY1J ENSG00000226941 -2.6802611813855997 [179] [32] -9 hSpCas9 negative selection 10223367
22409300 22409323 Y + 28162770 P31FUJ viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 -0.4264432748304984 [413] [361] -4 hSpCas9 negative selection 10223368
22417505 22417528 Y - 28162770 P31FUJ viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 0.47099652581662815 [131] [214] 5 hSpCas9 negative selection 10223369
22409308 22409331 Y - 28162770 TF1 viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 NaN [NaN] [897] 1 hSpCas9 negative selection 10392732
22409282 22409305 Y + 28162770 TF1 viability GCAGTGGAGGAACAAGAGGGTGG RBMY1J ENSG00000226941 NaN [NaN] [0] 1 hSpCas9 negative selection 10392733
22409300 22409323 Y + 28162770 TF1 viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 NaN [NaN] [393] 1 hSpCas9 negative selection 10392734
22417505 22417528 Y - 28162770 TF1 viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 NaN [NaN] [47] 1 hSpCas9 negative selection 10392735
22409308 22409331 Y - 28162770 SKM1 viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 0.6196300112685516 [214] [583] 6 hSpCas9 negative selection 10562098
22409282 22409305 Y + 28162770 SKM1 viability GCAGTGGAGGAACAAGAGGGTGG RBMY1J ENSG00000226941 -0.7622954518977376 [70] [73] -5 hSpCas9 negative selection 10562099
22409300 22409323 Y + 28162770 SKM1 viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 0.32360362422489364 [112] [249] 3 hSpCas9 negative selection 10562100
22417505 22417528 Y - 28162770 SKM1 viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 1.6054195257126707 [28] [155] 9 hSpCas9 negative selection 10562101
22409308 22409331 Y - 28162770 SKM1 viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 0.6196300112685516 [214] [583] 6 hSpCas9 negative selection 10731464
22409282 22409305 Y + 28162770 SKM1 viability GCAGTGGAGGAACAAGAGGGTGG RBMY1J ENSG00000226941 -0.7622954518977376 [70] [73] -5 hSpCas9 negative selection 10731465
22409300 22409323 Y + 28162770 SKM1 viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 0.32360362422489364 [112] [249] 3 hSpCas9 negative selection 10731466
22417505 22417528 Y - 28162770 SKM1 viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 1.6054195257126707 [28] [155] 9 hSpCas9 negative selection 10731467
22409308 22409331 Y - 28162770 PL21 viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 0.2389240749147714 [733] [376] 2 hSpCas9 negative selection 10900830
22409282 22409305 Y + 28162770 PL21 viability GCAGTGGAGGAACAAGAGGGTGG RBMY1J ENSG00000226941 -2.4691391721653115 [228] [17] -9 hSpCas9 negative selection 10900831
22409300 22409323 Y + 28162770 PL21 viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 0.6640867142491104 [347] [239] 6 hSpCas9 negative selection 10900832
22417505 22417528 Y - 28162770 PL21 viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 -0.31923454460425915 [214] [74] -2 hSpCas9 negative selection 10900833
22409308 22409331 Y - 28162770 P31FUJ viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 0.5106443572123756 [843] [1412] 6 hSpCas9 negative selection 11070196
22409282 22409305 Y + 28162770 P31FUJ viability GCAGTGGAGGAACAAGAGGGTGG RBMY1J ENSG00000226941 -2.6802611813855997 [179] [32] -9 hSpCas9 negative selection 11070197
22409300 22409323 Y + 28162770 P31FUJ viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 -0.4264432748304984 [413] [361] -4 hSpCas9 negative selection 11070198
22417505 22417528 Y - 28162770 P31FUJ viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 0.47099652581662815 [131] [214] 5 hSpCas9 negative selection 11070199
22409308 22409331 Y - 28162770 OCIAML5 viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 0.2689096269604283 [422] [919] 2 hSpCas9 negative selection 11239562
22409282 22409305 Y + 28162770 OCIAML5 viability GCAGTGGAGGAACAAGAGGGTGG RBMY1J ENSG00000226941 -1.969636167245173 [114] [52] -8 hSpCas9 negative selection 11239563
22409300 22409323 Y + 28162770 OCIAML5 viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 -0.6141567591858192 [250] [295] -4 hSpCas9 negative selection 11239564
22417505 22417528 Y - 28162770 OCIAML5 viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 -0.3374933980342387 [90] [129] -2 hSpCas9 negative selection 11239565
22409308 22409331 Y - 28162770 EOL1 viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 0.7505957052918397 [1434] [1271] 6 hSpCas9 negative selection 11408928
22409282 22409305 Y + 28162770 EOL1 viability GCAGTGGAGGAACAAGAGGGTGG RBMY1J ENSG00000226941 -2.143931966312232 [301] [35] -8 hSpCas9 negative selection 11408929
22409300 22409323 Y + 28162770 EOL1 viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 0.2712195502618344 [658] [418] 2 hSpCas9 negative selection 11408930
22417505 22417528 Y - 28162770 EOL1 viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 0.5460361483168047 [220] [169] 5 hSpCas9 negative selection 11408931
22409308 22409331 Y - 28162770 MOLM13 viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 0.7751707004675397 [989] [1224] 6 hSpCas9 negative selection 11578294
22409282 22409305 Y + 28162770 MOLM13 viability GCAGTGGAGGAACAAGAGGGTGG RBMY1J ENSG00000226941 -7.426928381763365 [237] [0] -9 hSpCas9 negative selection 11578295
22409300 22409323 Y + 28162770 MOLM13 viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 0.6655351405453412 [503] [577] 5 hSpCas9 negative selection 11578296
22417505 22417528 Y - 28162770 MOLM13 viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 -1.0085486623984083 [191] [68] -5 hSpCas9 negative selection 11578297
22409308 22409331 Y - 28162770 HEL viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 0.5782344325135815 [1051] [1005] 5 hSpCas9 negative selection 11747660
22409282 22409305 Y + 28162770 HEL viability GCAGTGGAGGAACAAGAGGGTGG RBMY1J ENSG00000226941 -4.370085208357227 [225] [6] -9 hSpCas9 negative selection 11747661
22409300 22409323 Y + 28162770 HEL viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 -0.3763699909473476 [455] [224] -3 hSpCas9 negative selection 11747662
22417505 22417528 Y - 28162770 HEL viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 0.6739334536039512 [182] [186] 6 hSpCas9 negative selection 11747663
22409308 22409331 Y - 28162770 MV411 viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 0.4849182767912448 [692] [816] 4 hSpCas9 negative selection 11917026
22409282 22409305 Y + 28162770 MV411 viability GCAGTGGAGGAACAAGAGGGTGG RBMY1J ENSG00000226941 -3.412813077242618 [176] [13] -9 hSpCas9 negative selection 11917027
22409300 22409323 Y + 28162770 MV411 viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 -0.1343106302857976 [356] [273] -1 hSpCas9 negative selection 11917028
22417505 22417528 Y - 28162770 MV411 viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 1.2247174742826918 [159] [314] 9 hSpCas9 negative selection 11917029
22409308 22409331 Y - 28162770 MONOMAC1 viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 0.0513825780922319 [462] [549] 0 hSpCas9 negative selection 12086392
22409282 22409305 Y + 28162770 MONOMAC1 viability GCAGTGGAGGAACAAGAGGGTGG RBMY1J ENSG00000226941 -1.9169289278668182 [111] [33] -8 hSpCas9 negative selection 12086393
22409300 22409323 Y + 28162770 MONOMAC1 viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 -0.009023217848803666 [272] [310] 0 hSpCas9 negative selection 12086394
22417505 22417528 Y - 28162770 MONOMAC1 viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 0.6394644206575668 [97] [174] 6 hSpCas9 negative selection 12086395
22409308 22409331 Y - 28162770 OCIAML2 viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 0.8205408740796993 [127] [1252] 7 hSpCas9 negative selection 12255758
22409282 22409305 Y + 28162770 OCIAML2 viability GCAGTGGAGGAACAAGAGGGTGG RBMY1J ENSG00000226941 -2.310165153048915 [33] [37] -8 hSpCas9 negative selection 12255759
22409300 22409323 Y + 28162770 OCIAML2 viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 -0.10405781529995661 [69] [360] -1 hSpCas9 negative selection 12255760
22417505 22417528 Y - 28162770 OCIAML2 viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 0.597541677399418 [30] [259] 6 hSpCas9 negative selection 12255761
22409308 22409331 Y - 28162770 OCIAML3 viability CCCAGGTGCCCTTCATGTGAGGG RBMY1J ENSG00000226941 0.7243242041570608 [240] [1201] 6 hSpCas9 negative selection 12425124
22409282 22409305 Y + 28162770 OCIAML3 viability GCAGTGGAGGAACAAGAGGGTGG RBMY1J ENSG00000226941 -2.2529707224890965 [59] [37] -8 hSpCas9 negative selection 12425125
22409300 22409323 Y + 28162770 OCIAML3 viability GGTGGCTTCCCTCACATGAAGGG RBMY1J ENSG00000226941 0.06895737239826616 [113] [360] 0 hSpCas9 negative selection 12425126
22417505 22417528 Y - 28162770 OCIAML3 viability CCATATGCTTCACGAGGATCAGG RBMY1J ENSG00000226941 -0.3657386526510459 [34] [81] -3 hSpCas9 negative selection 12425127