| 19411419 | 19411442 | 17 | - | 26472758 | Jiyoye | viability | AAAGGAAGTGACTGACAAGGCGG | RNF112 | ENSG00000128482 | 0.013511533019596511 | [267] | [203] | 0 | hSpCas9 | negative selection | 137815 | 19413582 | 19413605 | 17 | + | 26472758 | Jiyoye | viability | GGTGTTCCTGGTGGACACAGGGG | RNF112 | ENSG00000128482 | -1.1687702458578488 | [318] | [106] | -7 | hSpCas9 | negative selection | 137816 | 19414848 | 19414871 | 17 | + | 26472758 | Jiyoye | viability | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | -0.8515588868942949 | [66] | [27] | -5 | hSpCas9 | negative selection | 137817 | 19415186 | 19415209 | 17 | + | 26472758 | Jiyoye | viability | GCAGCTAGCTCAGGAAATCAAGG | RNF112 | ENSG00000128482 | -1.9713362417478564 | [25] | [4] | -8 | hSpCas9 | negative selection | 137818 | 19411406 | 19411429 | 17 | - | 26472758 | Jiyoye | viability | GACAAGGCGGGCCTTGGCATGGG | RNF112 | ENSG00000128482 | -1.0325241720072396 | [235] | [86] | -6 | hSpCas9 | negative selection | 137819 | 19411419 | 19411442 | 17 | - | 26472758 | KBM7 | viability | AAAGGAAGTGACTGACAAGGCGG | RNF112 | ENSG00000128482 | 0.5675757461071392 | [1089,795] | [973,359] | 6 | hSpCas9 | negative selection | 328933 | 19413582 | 19413605 | 17 | + | 26472758 | KBM7 | viability | GGTGTTCCTGGTGGACACAGGGG | RNF112 | ENSG00000128482 | -0.7540382876244838 | [807,588] | [96,277] | -6 | hSpCas9 | negative selection | 328934 | 19414848 | 19414871 | 17 | + | 26472758 | KBM7 | viability | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | -0.47904460377432057 | [180,147] | [60,49] | -4 | hSpCas9 | negative selection | 328935 | 19415186 | 19415209 | 17 | + | 26472758 | KBM7 | viability | GCAGCTAGCTCAGGAAATCAAGG | RNF112 | ENSG00000128482 | 1.323895225542535 | [51,86] | [68,97] | 9 | hSpCas9 | negative selection | 328936 | 19411406 | 19411429 | 17 | - | 26472758 | KBM7 | viability | GACAAGGCGGGCCTTGGCATGGG | RNF112 | ENSG00000128482 | 0.6368563215673099 | [489,453] | [346,343] | 7 | hSpCas9 | negative selection | 328937 | 19411419 | 19411442 | 17 | - | 26472758 | Raji | viability | AAAGGAAGTGACTGACAAGGCGG | RNF112 | ENSG00000128482 | 0.8930172545760695 | [477] | [205] | 7 | hSpCas9 | negative selection | 520051 | 19413582 | 19413605 | 17 | + | 26472758 | Raji | viability | GGTGTTCCTGGTGGACACAGGGG | RNF112 | ENSG00000128482 | -0.28983268681800006 | [294] | [55] | -2 | hSpCas9 | negative selection | 520052 | 19414848 | 19414871 | 17 | + | 26472758 | Raji | viability | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | 0.7267795331586296 | [137] | [52] | 6 | hSpCas9 | negative selection | 520053 | 19415186 | 19415209 | 17 | + | 26472758 | Raji | viability | GCAGCTAGCTCAGGAAATCAAGG | RNF112 | ENSG00000128482 | 0.9147384574312039 | [47] | [20] | 8 | hSpCas9 | negative selection | 520054 | 19411406 | 19411429 | 17 | - | 26472758 | Raji | viability | GACAAGGCGGGCCTTGGCATGGG | RNF112 | ENSG00000128482 | 0.09010554394176395 | [335] | [82] | 0 | hSpCas9 | negative selection | 520055 | 19411419 | 19411442 | 17 | - | 26472758 | K562 | viability | AAAGGAAGTGACTGACAAGGCGG | RNF112 | ENSG00000128482 | 0.7080749321654695 | [743] | [1025] | 6 | hSpCas9 | negative selection | 711169 | 19413582 | 19413605 | 17 | + | 26472758 | K562 | viability | GGTGTTCCTGGTGGACACAGGGG | RNF112 | ENSG00000128482 | -2.440524654151477 | [462] | [71] | -8 | hSpCas9 | negative selection | 711170 | 19414848 | 19414871 | 17 | + | 26472758 | K562 | viability | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | 0.6484851091242876 | [98] | [130] | 5 | hSpCas9 | negative selection | 711171 | 19415186 | 19415209 | 17 | + | 26472758 | K562 | viability | GCAGCTAGCTCAGGAAATCAAGG | RNF112 | ENSG00000128482 | -1.8430441135838924 | [84] | [19] | -7 | hSpCas9 | negative selection | 711172 | 19411406 | 19411429 | 17 | - | 26472758 | K562 | viability | GACAAGGCGGGCCTTGGCATGGG | RNF112 | ENSG00000128482 | 0.516790998079577 | [384] | [464] | 4 | hSpCas9 | negative selection | 711173 | 19413580 | 19413603 | 17 | + | 26627737 | DLD1 | viability | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | -0.2666559187889519 | [134] | [50,32,22] | -3 | hSpCas9 | negative selection | 796483 | 19414112 | 19414135 | 17 | + | 26627737 | DLD1 | viability | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | 0.03189103253494702 | [635] | [127,169,295] | 0 | hSpCas9 | negative selection | 796484 | 19414472 | 19414495 | 17 | + | 26627737 | DLD1 | viability | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | -0.6402525195124771 | [179] | [27,28,48] | -6 | hSpCas9 | negative selection | 796485 | 19414848 | 19414871 | 17 | + | 26627737 | DLD1 | viability | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | 0.7052645129859669 | [199] | [59,123,119] | 7 | hSpCas9 | negative selection | 796486 | 19413580 | 19413603 | 17 | + | 26627737 | GBM cells | viability after 5 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | 0.42942859158446556 | [8] | [8,3] | 6 | hSpCas9 | negative selection | 878798 | 19414112 | 19414135 | 17 | + | 26627737 | GBM cells | viability after 5 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | 0.656998895284419 | [216] | [165,200] | 8 | hSpCas9 | negative selection | 878799 | 19414472 | 19414495 | 17 | + | 26627737 | GBM cells | viability after 5 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | 0.4117265898510065 | [81] | [73,42] | 6 | hSpCas9 | negative selection | 878800 | 19414848 | 19414871 | 17 | + | 26627737 | GBM cells | viability after 5 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | -1.3796216244882962 | [130] | [26,26] | -9 | hSpCas9 | negative selection | 878801 | 19413580 | 19413603 | 17 | + | 26627737 | GBM cells | viability after 13 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | 0.15804501319162956 | [8] | [5,4] | 2 | hSpCas9 | negative selection | 961113 | 19414112 | 19414135 | 17 | + | 26627737 | GBM cells | viability after 13 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | 0.379879771634331 | [216] | [150,154] | 5 | hSpCas9 | negative selection | 961114 | 19414472 | 19414495 | 17 | + | 26627737 | GBM cells | viability after 13 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | 0.4197254113794482 | [81] | [53,63] | 5 | hSpCas9 | negative selection | 961115 | 19414848 | 19414871 | 17 | + | 26627737 | GBM cells | viability after 13 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | -0.754463295565075 | [130] | [29,51] | -7 | hSpCas9 | negative selection | 961116 | 19413580 | 19413603 | 17 | + | 26627737 | GBM cells | viability after 21 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | -0.45511531103402536 | [8] | [1,4] | -4 | hSpCas9 | negative selection | 1043428 | 19414112 | 19414135 | 17 | + | 26627737 | GBM cells | viability after 21 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | 0.7706107524060037 | [216] | [209,192] | 7 | hSpCas9 | negative selection | 1043429 | 19414472 | 19414495 | 17 | + | 26627737 | GBM cells | viability after 21 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | 0.6590458788913346 | [81] | [73,66] | 6 | hSpCas9 | negative selection | 1043430 | 19414848 | 19414871 | 17 | + | 26627737 | GBM cells | viability after 21 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | -0.5473398347268119 | [130] | [43,52] | -5 | hSpCas9 | negative selection | 1043431 | 19413580 | 19413603 | 17 | + | 26627737 | RPE1 | viability after 9 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | -1.0283385167161174 | [224] | [20,51] | -6 | hSpCas9 | negative selection | 1125743 | 19414112 | 19414135 | 17 | + | 26627737 | RPE1 | viability after 9 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | 0.6805438389698102 | [576] | [268,315] | 4 | hSpCas9 | negative selection | 1125744 | 19414472 | 19414495 | 17 | + | 26627737 | RPE1 | viability after 9 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | 1.0596383673792227 | [261] | [218,108] | 6 | hSpCas9 | negative selection | 1125745 | 19414848 | 19414871 | 17 | + | 26627737 | RPE1 | viability after 9 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | 0.12731104040684293 | [279] | [124,57] | 0 | hSpCas9 | negative selection | 1125746 | 19413580 | 19413603 | 17 | + | 26627737 | RPE1 | viability after 12 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | -1.9568403768245768 | [224] | [17,12] | -8 | hSpCas9 | negative selection | 1208058 | 19414112 | 19414135 | 17 | + | 26627737 | RPE1 | viability after 12 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | 1.0893814387441665 | [576] | [341,316] | 6 | hSpCas9 | negative selection | 1208059 | 19414472 | 19414495 | 17 | + | 26627737 | RPE1 | viability after 12 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | 1.8665476055913224 | [261] | [245,267] | 8 | hSpCas9 | negative selection | 1208060 | 19414848 | 19414871 | 17 | + | 26627737 | RPE1 | viability after 12 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | -0.6042314074900701 | [279] | [14,85] | -4 | hSpCas9 | negative selection | 1208061 | 19413580 | 19413603 | 17 | + | 26627737 | RPE1 | viability after 15 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | -0.7769441048960213 | [224] | [28,44] | -5 | hSpCas9 | negative selection | 1290373 | 19414112 | 19414135 | 17 | + | 26627737 | RPE1 | viability after 15 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | 0.5246294250823215 | [576] | [273,196] | 3 | hSpCas9 | negative selection | 1290374 | 19414472 | 19414495 | 17 | + | 26627737 | RPE1 | viability after 15 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | 2.4589580916876375 | [261] | [435,379] | 9 | hSpCas9 | negative selection | 1290375 | 19414848 | 19414871 | 17 | + | 26627737 | RPE1 | viability after 15 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | 0.631180612565814 | [279] | [168,77] | 4 | hSpCas9 | negative selection | 1290376 | 19413580 | 19413603 | 17 | + | 26627737 | RPE1 | viability after 18 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | -2.2236732129752026 | [224] | [12,12] | -8 | hSpCas9 | negative selection | 1372688 | 19414112 | 19414135 | 17 | + | 26627737 | RPE1 | viability after 18 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | 0.7401607117436896 | [576] | [160,365] | 4 | hSpCas9 | negative selection | 1372689 | 19414472 | 19414495 | 17 | + | 26627737 | RPE1 | viability after 18 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | 2.7027011429259042 | [261] | [512,403] | 9 | hSpCas9 | negative selection | 1372690 | 19414848 | 19414871 | 17 | + | 26627737 | RPE1 | viability after 18 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | -0.6447153229228499 | [279] | [57,37] | -4 | hSpCas9 | negative selection | 1372691 | 19413580 | 19413603 | 17 | + | 26627737 | HeLa | viability after 8 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | -0.23513110801030923 | [783] | [344,325,215] | -2 | hSpCas9 | negative selection | 1455003 | 19414112 | 19414135 | 17 | + | 26627737 | HeLa | viability after 8 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | 0.3444758097554088 | [303] | [188,158,160] | 3 | hSpCas9 | negative selection | 1455004 | 19414472 | 19414495 | 17 | + | 26627737 | HeLa | viability after 8 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | 0.7652129641916995 | [136] | [158,16,137] | 6 | hSpCas9 | negative selection | 1455005 | 19414848 | 19414871 | 17 | + | 26627737 | HeLa | viability after 8 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | -0.18279681393859476 | [313] | [110,200,51] | -2 | hSpCas9 | negative selection | 1455006 | 19413580 | 19413603 | 17 | + | 26627737 | HeLa | viability after 12 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | -0.06557021813237007 | [783] | [188,387,339] | 0 | hSpCas9 | negative selection | 1537318 | 19414112 | 19414135 | 17 | + | 26627737 | HeLa | viability after 12 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | 0.5025980167414548 | [303] | [102,260,158] | 4 | hSpCas9 | negative selection | 1537319 | 19414472 | 19414495 | 17 | + | 26627737 | HeLa | viability after 12 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | -0.7529500186632352 | [136] | [68,12,21] | -6 | hSpCas9 | negative selection | 1537320 | 19414848 | 19414871 | 17 | + | 26627737 | HeLa | viability after 12 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | -0.6063649570616654 | [313] | [87,120,42] | -5 | hSpCas9 | negative selection | 1537321 | 19413580 | 19413603 | 17 | + | 26627737 | HeLa | viability after 15 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | -0.5029464778761854 | [783] | [151,318,203] | -4 | hSpCas9 | negative selection | 1619633 | 19414112 | 19414135 | 17 | + | 26627737 | HeLa | viability after 15 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | 1.283656427919366 | [303] | [156,359,395] | 8 | hSpCas9 | negative selection | 1619634 | 19414472 | 19414495 | 17 | + | 26627737 | HeLa | viability after 15 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | 0.10411384297481496 | [136] | [108,48,17] | 0 | hSpCas9 | negative selection | 1619635 | 19414848 | 19414871 | 17 | + | 26627737 | HeLa | viability after 15 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | -0.6945275829592785 | [313] | [21,120,95] | -6 | hSpCas9 | negative selection | 1619636 | 19413580 | 19413603 | 17 | + | 26627737 | HeLa | viability after 18 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | -0.5026145694182202 | [783] | [98,267,203] | -4 | hSpCas9 | negative selection | 1701948 | 19414112 | 19414135 | 17 | + | 26627737 | HeLa | viability after 18 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | 1.299293165696962 | [303] | [106,303,395] | 8 | hSpCas9 | negative selection | 1701949 | 19414472 | 19414495 | 17 | + | 26627737 | HeLa | viability after 18 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | 0.06149759491479956 | [136] | [70,38,17] | 0 | hSpCas9 | negative selection | 1701950 | 19414848 | 19414871 | 17 | + | 26627737 | HeLa | viability after 18 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | -0.6881019247184097 | [313] | [13,101,95] | -6 | hSpCas9 | negative selection | 1701951 | 19413580 | 19413603 | 17 | + | 26627737 | HCT116 | viability after 6 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | -0.21689335027704035 | [565] | [53,88] | -1 | hSpCas9 | negative selection | 1784263 | 19414112 | 19414135 | 17 | + | 26627737 | HCT116 | viability after 6 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | 1.435456807570675 | [383] | [384,40] | 7 | hSpCas9 | negative selection | 1784264 | 19414472 | 19414495 | 17 | + | 26627737 | HCT116 | viability after 6 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | 0.7056527140240085 | [81] | [11,25] | 4 | hSpCas9 | negative selection | 1784265 | 19414848 | 19414871 | 17 | + | 26627737 | HCT116 | viability after 6 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | 0.08853924115759437 | [432] | [63,76] | 0 | hSpCas9 | negative selection | 1784266 | 19413580 | 19413603 | 17 | + | 26627737 | HCT116 | viability after 8 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | -0.3220775107263002 | [680] | [243,313,340] | -4 | hSpCas9 | negative selection | 1866578 | 19414112 | 19414135 | 17 | + | 26627737 | HCT116 | viability after 8 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | -0.4733967695173096 | [464] | [165,175,210] | -5 | hSpCas9 | negative selection | 1866579 | 19414472 | 19414495 | 17 | + | 26627737 | HCT116 | viability after 8 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | 1.674579847957977 | [30] | [70,47,44] | 9 | hSpCas9 | negative selection | 1866580 | 19414848 | 19414871 | 17 | + | 26627737 | HCT116 | viability after 8 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | 0.4412737024407219 | [161] | [193,138,32] | 4 | hSpCas9 | negative selection | 1866581 | 19413580 | 19413603 | 17 | + | 26627737 | HCT116 | viability after 9 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | -0.4592542824908892 | [565] | [143,82] | -3 | hSpCas9 | negative selection | 1948893 | 19414112 | 19414135 | 17 | + | 26627737 | HCT116 | viability after 9 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | 1.0554079943816685 | [383] | [111,292] | 7 | hSpCas9 | negative selection | 1948894 | 19414472 | 19414495 | 17 | + | 26627737 | HCT116 | viability after 9 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | 1.3280884049639354 | [81] | [121,1] | 8 | hSpCas9 | negative selection | 1948895 | 19414848 | 19414871 | 17 | + | 26627737 | HCT116 | viability after 9 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | -0.9080795956973732 | [432] | [50,69] | -6 | hSpCas9 | negative selection | 1948896 | 19413580 | 19413603 | 17 | + | 26627737 | HCT116 | viability after 12 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | -0.3725482727283188 | [680] | [127,220,491] | -4 | hSpCas9 | negative selection | 2031208 | 19414112 | 19414135 | 17 | + | 26627737 | HCT116 | viability after 12 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | -0.5697928206262537 | [464] | [76,180,243] | -6 | hSpCas9 | negative selection | 2031209 | 19414472 | 19414495 | 17 | + | 26627737 | HCT116 | viability after 12 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | 1.7613388852043819 | [30] | [44,30,89] | 9 | hSpCas9 | negative selection | 2031210 | 19414848 | 19414871 | 17 | + | 26627737 | HCT116 | viability after 12 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | 0.6570704952705957 | [161] | [237,66,86] | 6 | hSpCas9 | negative selection | 2031211 | 19413580 | 19413603 | 17 | + | 26627737 | HCT116 | viability after 15 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | -0.47933081067512195 | [680] | [142,328,351] | -5 | hSpCas9 | negative selection | 2113523 | 19414112 | 19414135 | 17 | + | 26627737 | HCT116 | viability after 15 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | -0.49129398487524545 | [464] | [131,168,260] | -5 | hSpCas9 | negative selection | 2113524 | 19414472 | 19414495 | 17 | + | 26627737 | HCT116 | viability after 15 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | 1.5865551708246193 | [30] | [53,13,91] | 9 | hSpCas9 | negative selection | 2113525 | 19414848 | 19414871 | 17 | + | 26627737 | HCT116 | viability after 15 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | 0.7505422023244032 | [161] | [183,138,149] | 6 | hSpCas9 | negative selection | 2113526 | 19413580 | 19413603 | 17 | + | 26627737 | HCT116 | viability after 18 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | 0.21931709129909605 | [680] | [160,361,639] | 2 | hSpCas9 | negative selection | 2195838 | 19414112 | 19414135 | 17 | + | 26627737 | HCT116 | viability after 18 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | -0.582692126151475 | [464] | [93,192,160] | -5 | hSpCas9 | negative selection | 2195839 | 19414472 | 19414495 | 17 | + | 26627737 | HCT116 | viability after 18 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | 1.0716008973895041 | [30] | [22,4,69] | 8 | hSpCas9 | negative selection | 2195840 | 19414848 | 19414871 | 17 | + | 26627737 | HCT116 | viability after 18 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | 1.0081432749897548 | [161] | [270,132,65] | 7 | hSpCas9 | negative selection | 2195841 | 19411395 | 19411418 | 17 | + | 24336569 | HL60 | viability | CATCCCAGCCTCCCATGCCAAGG | RNF112 | ENSG00000128482 | 0.5425202889214437 | [230] | [711] | 5 | hSpCas9 | negative selection | 2289878 | 19411406 | 19411429 | 17 | - | 24336569 | HL60 | viability | GACAAGGCGGGCCTTGGCATGGG | RNF112 | ENSG00000128482 | 0.4112043788727803 | [510] | [1437] | 4 | hSpCas9 | negative selection | 2289879 | 19411412 | 19411435 | 17 | - | 24336569 | HL60 | viability | GTGACTGACAAGGCGGGCCTTGG | RNF112 | ENSG00000128482 | -0.5044529300351781 | [1030] | [1537] | -4 | hSpCas9 | negative selection | 2289880 | 19411418 | 19411441 | 17 | - | 24336569 | HL60 | viability | AAGGAAGTGACTGACAAGGCGGG | RNF112 | ENSG00000128482 | -0.5036971013119445 | [66] | [99] | -4 | hSpCas9 | negative selection | 2289881 | 19411440 | 19411463 | 17 | + | 24336569 | HL60 | viability | TTTGTCATCGGCTTGGCAAACGG | RNF112 | ENSG00000128482 | 0.3215605823670564 | [1009] | [2670] | 3 | hSpCas9 | negative selection | 2289882 | 19411639 | 19411662 | 17 | + | 24336569 | HL60 | viability | CAGAGCTTCATGGGAAACAGCGG | RNF112 | ENSG00000128482 | 0.25037946312354875 | [869] | [2189] | 2 | hSpCas9 | negative selection | 2289883 | 19411649 | 19411672 | 17 | + | 24336569 | HL60 | viability | TGGGAAACAGCGGCAACAGTTGG | RNF112 | ENSG00000128482 | -0.7377376529332988 | [958] | [1216] | -6 | hSpCas9 | negative selection | 2289884 | 19411395 | 19411418 | 17 | + | 24336569 | KBM7 | viability | CATCCCAGCCTCCCATGCCAAGG | RNF112 | ENSG00000128482 | -0.30950306114591 | [228] | [503] | -3 | hSpCas9 | negative selection | 2357055 | 19411406 | 19411429 | 17 | - | 24336569 | KBM7 | viability | GACAAGGCGGGCCTTGGCATGGG | RNF112 | ENSG00000128482 | -0.32855509340660805 | [499] | [1085] | -3 | hSpCas9 | negative selection | 2357056 | 19411412 | 19411435 | 17 | - | 24336569 | KBM7 | viability | GTGACTGACAAGGCGGGCCTTGG | RNF112 | ENSG00000128482 | 0.9382511236475314 | [604] | [3161] | 7 | hSpCas9 | negative selection | 2357057 | 19411418 | 19411441 | 17 | - | 24336569 | KBM7 | viability | AAGGAAGTGACTGACAAGGCGGG | RNF112 | ENSG00000128482 | -1.902145060014364 | [147] | [107] | -8 | hSpCas9 | negative selection | 2357058 | 19411440 | 19411463 | 17 | + | 24336569 | KBM7 | viability | TTTGTCATCGGCTTGGCAAACGG | RNF112 | ENSG00000128482 | 1.0847990857805931 | [609] | [3528] | 8 | hSpCas9 | negative selection | 2357059 | 19411639 | 19411662 | 17 | + | 24336569 | KBM7 | viability | CAGAGCTTCATGGGAAACAGCGG | RNF112 | ENSG00000128482 | -0.409515429917753 | [878] | [1804] | -3 | hSpCas9 | negative selection | 2357060 | 19411649 | 19411672 | 17 | + | 24336569 | KBM7 | viability | TGGGAAACAGCGGCAACAGTTGG | RNF112 | ENSG00000128482 | 0.22087761968703368 | [620] | [1973] | 2 | hSpCas9 | negative selection | 2357061 | 19411640 | 19411663 | 17 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | CAGAGCTTCATGGGAAACAGCGG | RNF112 | ENSG00000128482 | 0.2936506393539813 | [3,3] | [4,3] | 6 | hSpCas9 | positive selection | 3017116 | 19413384 | 19413407 | 17 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | CCTTCTTGCTGGGGAAAGAAGGG | RNF112 | ENSG00000128482 | -1.1666798561982639 | [2,2] | [0,0] | -9 | hSpCas9 | positive selection | 3017117 | 19414449 | 19414472 | 17 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | GATGTTTGTCCACGTGGCCGAGG | RNF112 | ENSG00000128482 | -0.09803952213998623 | [4,4] | [4,2] | -1 | hSpCas9 | positive selection | 3017118 | 19411640 | 19411663 | 17 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | CAGAGCTTCATGGGAAACAGCGG | RNF112 | ENSG00000128482 | -0.5583366022633716 | [3,3] | [3,0] | -7 | hSpCas9 | positive selection | 3084974 | 19413384 | 19413407 | 17 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | CCTTCTTGCTGGGGAAAGAAGGG | RNF112 | ENSG00000128482 | -0.8442790745331494 | [2,2] | [0,0] | -9 | hSpCas9 | positive selection | 3084975 | 19414449 | 19414472 | 17 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | GATGTTTGTCCACGTGGCCGAGG | RNF112 | ENSG00000128482 | 0.2764525954569246 | [4,4] | [4,3] | 5 | hSpCas9 | positive selection | 3084976 | 19411629 | 19411652 | | + | 24336571 | A375 | resistance to PLX after 7 days | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | -0.16439874273829314 | [5,4] | [3,4] | -5 | hSpCas9 | positive selection | 3141181 | 19411629 | 19411652 | | + | 24336571 | A375 | resistance to PLX after 14 days | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.1445783655406052 | [6,4] | [2,2] | 1 | hSpCas9 | positive selection | 3198974 | 19411629 | 19411652 | | + | 24336571 | A375 | viability after 7 days | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.0353183488228932 | [4] | [5,4] | 0 | hSpCas9 | negative selection | 3256767 | 19411629 | 19411652 | | + | 24336571 | A375 | viability after 14 days | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.15909457768085744 | [4] | [6,4] | 2 | hSpCas9 | negative selection | 3314560 | 19413356 | 19413379 | 17 | - | 27383988 | 293T | resistance to West Nile virus (flavivirus) | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -2.455200788993988 | [838,838] | [0,0] | -9 | hSpCas9 | positive selection | 3390045 | 19411629 | 19411652 | 17 | + | 27383988 | 293T | resistance to West Nile virus (flavivirus) | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.26864152467366925 | [126,126] | [0,0] | 1 | hSpCas9 | positive selection | 3390046 | 19411639 | 19411662 | 17 | + | 26780180 | HT29 | viability (Avana library 4 designs) | CAGAGCTTCATGGGAAACAGCGG | RNF112 | ENSG00000128482 | 0.832076792183803 | [] | [] | 3 | hSpCas9 | negative selection | 3455487 | 19413383 | 19413406 | 17 | + | 26780180 | HT29 | viability (Avana library 4 designs) | CCTTCTTGCTGGGGAAAGAAGGG | RNF112 | ENSG00000128482 | 1.30119788439972 | [] | [] | 5 | hSpCas9 | negative selection | 3455488 | 19414448 | 19414471 | 17 | + | 26780180 | HT29 | viability (Avana library 4 designs) | GATGTTTGTCCACGTGGCCGAGG | RNF112 | ENSG00000128482 | 0.260769231880564 | [] | [] | 0 | hSpCas9 | negative selection | 3455489 | 19414448 | 19414471 | 17 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GATGTTTGTCCACGTGGCCGAGG | RNF112 | ENSG00000128482 | 6.2545676938664 | [] | [] | 9 | hSpCas9 | negative selection | 3553500 | 19411639 | 19411662 | 17 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | CAGAGCTTCATGGGAAACAGCGG | RNF112 | ENSG00000128482 | 3.87632224247363 | [] | [] | 6 | hSpCas9 | negative selection | 3553501 | 19413383 | 19413406 | 17 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | CCTTCTTGCTGGGGAAAGAAGGG | RNF112 | ENSG00000128482 | -0.62578118488565 | [] | [] | -1 | hSpCas9 | negative selection | 3553502 | 19413561 | 19413584 | 17 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | CCTACCCCCTGCATAGGTGGCGG | RNF112 | ENSG00000128482 | 2.45868881085377 | [] | [] | 3 | hSpCas9 | negative selection | 3553503 | 19414448 | 19414471 | 17 | + | 26780180 | A375 | viability (Avana lentiGuide) | GATGTTTGTCCACGTGGCCGAGG | RNF112 | ENSG00000128482 | -5.82530101431328 | [] | [] | -8 | hSpCas9 | negative selection | 3662159 | 19411639 | 19411662 | 17 | + | 26780180 | A375 | viability (Avana lentiGuide) | CAGAGCTTCATGGGAAACAGCGG | RNF112 | ENSG00000128482 | -3.55507269046263 | [] | [] | -6 | hSpCas9 | negative selection | 3662160 | 19413383 | 19413406 | 17 | + | 26780180 | A375 | viability (Avana lentiGuide) | CCTTCTTGCTGGGGAAAGAAGGG | RNF112 | ENSG00000128482 | 6.10306426232307 | [] | [] | 5 | hSpCas9 | negative selection | 3662161 | 19413561 | 19413584 | 17 | + | 26780180 | A375 | viability (Avana lentiGuide) | CCTACCCCCTGCATAGGTGGCGG | RNF112 | ENSG00000128482 | 0.760635182820705 | [] | [] | 0 | hSpCas9 | negative selection | 3662162 | 19414448 | 19414471 | 17 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GATGTTTGTCCACGTGGCCGAGG | RNF112 | ENSG00000128482 | 0.3134521569289139 | [5] | [7,6] | 8 | hSpCas9 | positive selection | 3770766 | 19411639 | 19411662 | 17 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | CAGAGCTTCATGGGAAACAGCGG | RNF112 | ENSG00000128482 | -0.17924025287877568 | [4] | [4,2] | -3 | hSpCas9 | positive selection | 3770767 | 19413383 | 19413406 | 17 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | CCTTCTTGCTGGGGAAAGAAGGG | RNF112 | ENSG00000128482 | -0.147767515226288 | [4] | [4,3] | -2 | hSpCas9 | positive selection | 3770768 | 19413561 | 19413584 | 17 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | CCTACCCCCTGCATAGGTGGCGG | RNF112 | ENSG00000128482 | 0.2814870839034723 | [4] | [5,5] | 7 | hSpCas9 | positive selection | 3770769 | 19414448 | 19414471 | 17 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GATGTTTGTCCACGTGGCCGAGG | RNF112 | ENSG00000128482 | 0.27569043520735603 | [6] | [6,6] | 7 | hSpCas9 | positive selection | 3879373 | 19411639 | 19411662 | 17 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | CAGAGCTTCATGGGAAACAGCGG | RNF112 | ENSG00000128482 | 0.1483058952909572 | [4] | [5,4] | 3 | hSpCas9 | positive selection | 3879374 | 19413383 | 19413406 | 17 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | CCTTCTTGCTGGGGAAAGAAGGG | RNF112 | ENSG00000128482 | -0.6303861538427726 | [3] | [0,2] | -7 | hSpCas9 | positive selection | 3879375 | 19413561 | 19413584 | 17 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | CCTACCCCCTGCATAGGTGGCGG | RNF112 | ENSG00000128482 | -0.7458642573575369 | [4] | [1,2] | -7 | hSpCas9 | positive selection | 3879376 | 19413356 | 19413379 | 17 | - | 26780180 | A375 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | 0.816287929963872 | [] | [] | 3 | hSpCas9 | negative selection | 3989489 | 19411629 | 19411652 | 17 | + | 26780180 | A375 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.63592965798206 | [] | [] | 2 | hSpCas9 | negative selection | 3989490 | 19413340 | 19413363 | 17 | + | 26780180 | A375 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | 0.776659197504213 | [] | [] | 3 | hSpCas9 | negative selection | 3989491 | 19413356 | 19413379 | 17 | - | 26780180 | HT29 | viability (GeCKOv2 library) | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | 0.906899079928235 | [] | [] | 4 | hSpCas9 | negative selection | 4097455 | 19411629 | 19411652 | 17 | + | 26780180 | HT29 | viability (GeCKOv2 library) | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.840881834925767 | [] | [] | 3 | hSpCas9 | negative selection | 4097456 | 19413340 | 19413363 | 17 | + | 26780180 | HT29 | viability (GeCKOv2 library) | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | 0.267684608309483 | [] | [] | 0 | hSpCas9 | negative selection | 4097457 | 19411629 | 19411652 | 17 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | -0.291568985835321 | [2] | [0,1] | -6 | hSpCas9 | positive selection | 4166691 | 19411629 | 19411652 | 17 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiGuide) | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | -0.8742301791588831 | [3] | [0,0,0,0] | -9 | hSpCas9 | positive selection | 4230713 | 19413340 | 19413363 | 17 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | -0.1396753620480911 | [3] | [3,0] | -3 | hSpCas9 | positive selection | 4295101 | 19413356 | 19413379 | 17 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.06743497044677155 | [4] | [3,3] | -1 | hSpCas9 | positive selection | 4359354 | 19411629 | 19411652 | 17 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.22281880475095242 | [2] | [3,1] | 4 | hSpCas9 | positive selection | 4359355 | 19413354 | 19413376 | 17 | + | 27760321 | OCIAML3 | viability | CGCCAGGGGCATATGGATGTGG | RNF112 | ENSG00000128482 | -0.261307730111041 | [465,391] | [277,279] | -3 | hSpCas9 | negative selection | 4434995 | 19414465 | 19414487 | 17 | - | 27760321 | OCIAML3 | viability | TAATGCTTGCCCATCACCTCGG | RNF112 | ENSG00000128482 | -0.3632693473350858 | [450,358] | [196,306] | -4 | hSpCas9 | negative selection | 4434996 | 19414594 | 19414616 | 17 | - | 27760321 | OCIAML3 | viability | GGATGAGTCACGAACTAAGAGG | RNF112 | ENSG00000128482 | -0.40916563007881623 | [210,143] | [104,100] | -4 | hSpCas9 | negative selection | 4434997 | 19413354 | 19413376 | 17 | + | 27760321 | OCIAML2 | viability | CGCCAGGGGCATATGGATGTGG | RNF112 | ENSG00000128482 | 0.19274648773649888 | [465,391] | [373,422] | 2 | hSpCas9 | negative selection | 4518458 | 19414465 | 19414487 | 17 | - | 27760321 | OCIAML2 | viability | TAATGCTTGCCCATCACCTCGG | RNF112 | ENSG00000128482 | 0.02372043131065031 | [450,358] | [302,367] | 0 | hSpCas9 | negative selection | 4518459 | 19414594 | 19414616 | 17 | - | 27760321 | OCIAML2 | viability | GGATGAGTCACGAACTAAGAGG | RNF112 | ENSG00000128482 | 0.898402256192673 | [210,143] | [228,310] | 9 | hSpCas9 | negative selection | 4518460 | 19413354 | 19413376 | 17 | + | 27760321 | MV411 | viability | CGCCAGGGGCATATGGATGTGG | RNF112 | ENSG00000128482 | 0.7700203782548843 | [465,391] | [639,241] | 5 | hSpCas9 | negative selection | 4601921 | 19414465 | 19414487 | 17 | - | 27760321 | MV411 | viability | TAATGCTTGCCCATCACCTCGG | RNF112 | ENSG00000128482 | -0.26357500910976805 | [450,358] | [86,422] | -2 | hSpCas9 | negative selection | 4601922 | 19414594 | 19414616 | 17 | - | 27760321 | MV411 | viability | GGATGAGTCACGAACTAAGAGG | RNF112 | ENSG00000128482 | 1.224090282820671 | [210,143] | [378,106] | 8 | hSpCas9 | negative selection | 4601923 | 19413354 | 19413376 | 17 | + | 27760321 | HL60 | viability | CGCCAGGGGCATATGGATGTGG | RNF112 | ENSG00000128482 | 0.6913808328795232 | [465,391] | [538,589] | 7 | hSpCas9 | negative selection | 4685384 | 19414465 | 19414487 | 17 | - | 27760321 | HL60 | viability | TAATGCTTGCCCATCACCTCGG | RNF112 | ENSG00000128482 | 0.23380483850425823 | [450,358] | [276,502] | 3 | hSpCas9 | negative selection | 4685385 | 19414594 | 19414616 | 17 | - | 27760321 | HL60 | viability | GGATGAGTCACGAACTAAGAGG | RNF112 | ENSG00000128482 | 0.18673092216381093 | [210,143] | [146,179] | 2 | hSpCas9 | negative selection | 4685386 | 19413354 | 19413376 | 17 | + | 27760321 | HT1080 | viability | CGCCAGGGGCATATGGATGTGG | RNF112 | ENSG00000128482 | -0.567638554897588 | [391,305] | [152,28] | -3 | hSpCas9 | negative selection | 4768847 | 19414465 | 19414487 | 17 | - | 27760321 | HT1080 | viability | TAATGCTTGCCCATCACCTCGG | RNF112 | ENSG00000128482 | -0.07459511539475683 | [358,279] | [138,100] | 0 | hSpCas9 | negative selection | 4768848 | 19414594 | 19414616 | 17 | - | 27760321 | HT1080 | viability | GGATGAGTCACGAACTAAGAGG | RNF112 | ENSG00000128482 | 1.188457701295534 | [143,112] | [99,134] | 6 | hSpCas9 | negative selection | 4768849 | 19413354 | 19413376 | 17 | + | 27760321 | HT29 | viability after 7 days | CGCCAGGGGCATATGGATGTGG | RNF112 | ENSG00000128482 | 0.5023110261217125 | [391,305] | [557,706,629] | 7 | hSpCas9 | negative selection | 4852310 | 19414465 | 19414487 | 17 | - | 27760321 | HT29 | viability after 7 days | TAATGCTTGCCCATCACCTCGG | RNF112 | ENSG00000128482 | 0.006326718754517929 | [358,279] | [236,368,599] | 0 | hSpCas9 | negative selection | 4852311 | 19414594 | 19414616 | 17 | - | 27760321 | HT29 | viability after 7 days | GGATGAGTCACGAACTAAGAGG | RNF112 | ENSG00000128482 | 0.8291661232455534 | [143,112] | [223,494,155] | 9 | hSpCas9 | negative selection | 4852312 | 19413354 | 19413376 | 17 | + | 27760321 | HT29 | viability after 25 days | CGCCAGGGGCATATGGATGTGG | RNF112 | ENSG00000128482 | 0.6601664086890975 | [391,305] | [592,653,646] | 7 | hSpCas9 | negative selection | 4935773 | 19414465 | 19414487 | 17 | - | 27760321 | HT29 | viability after 25 days | TAATGCTTGCCCATCACCTCGG | RNF112 | ENSG00000128482 | 0.2386635756615131 | [358,279] | [381,514,393] | 2 | hSpCas9 | negative selection | 4935774 | 19414594 | 19414616 | 17 | - | 27760321 | HT29 | viability after 25 days | GGATGAGTCACGAACTAAGAGG | RNF112 | ENSG00000128482 | -0.04978876448720326 | [143,112] | [60,215,154] | 0 | hSpCas9 | negative selection | 4935775 | 19413354 | 19413376 | 17 | + | 27760321 | HT29 | viability after 22 days | CGCCAGGGGCATATGGATGTGG | RNF112 | ENSG00000128482 | 0.6369712833954047 | [391,305] | [537,680,665] | 7 | hSpCas9 | negative selection | 5019236 | 19414465 | 19414487 | 17 | - | 27760321 | HT29 | viability after 22 days | TAATGCTTGCCCATCACCTCGG | RNF112 | ENSG00000128482 | -0.07644173653667857 | [358,279] | [212,338,503] | -1 | hSpCas9 | negative selection | 5019237 | 19414594 | 19414616 | 17 | - | 27760321 | HT29 | viability after 22 days | GGATGAGTCACGAACTAAGAGG | RNF112 | ENSG00000128482 | 0.2068432095736381 | [143,112] | [157,173,182] | 2 | hSpCas9 | negative selection | 5019238 | 19413354 | 19413376 | 17 | + | 27760321 | HT29 | viability after 19 days | CGCCAGGGGCATATGGATGTGG | RNF112 | ENSG00000128482 | 0.29288335074398086 | [391,305] | [368,593,490] | 2 | hSpCas9 | negative selection | 5102699 | 19414465 | 19414487 | 17 | - | 27760321 | HT29 | viability after 19 days | TAATGCTTGCCCATCACCTCGG | RNF112 | ENSG00000128482 | -0.4420622190601326 | [358,279] | [443,218,165] | -4 | hSpCas9 | negative selection | 5102700 | 19414594 | 19414616 | 17 | - | 27760321 | HT29 | viability after 19 days | GGATGAGTCACGAACTAAGAGG | RNF112 | ENSG00000128482 | 0.2902996854532143 | [143,112] | [195,220,125] | 2 | hSpCas9 | negative selection | 5102701 | 19413354 | 19413376 | 17 | + | 27760321 | HT29 | viability after 16 days | CGCCAGGGGCATATGGATGTGG | RNF112 | ENSG00000128482 | 0.6163542641619205 | [391,305] | [513,853,412] | 7 | hSpCas9 | negative selection | 5186162 | 19414465 | 19414487 | 17 | - | 27760321 | HT29 | viability after 16 days | TAATGCTTGCCCATCACCTCGG | RNF112 | ENSG00000128482 | -0.03836946548622178 | [358,279] | [553,178,334] | 0 | hSpCas9 | negative selection | 5186163 | 19414594 | 19414616 | 17 | - | 27760321 | HT29 | viability after 16 days | GGATGAGTCACGAACTAAGAGG | RNF112 | ENSG00000128482 | -0.1356462107805596 | [143,112] | [130,119,141] | -1 | hSpCas9 | negative selection | 5186164 | 19413354 | 19413376 | 17 | + | 27760321 | HT29 | viability after 13 days | CGCCAGGGGCATATGGATGTGG | RNF112 | ENSG00000128482 | 0.520631357766643 | [391,305] | [340,923,483] | 6 | hSpCas9 | negative selection | 5269625 | 19414465 | 19414487 | 17 | - | 27760321 | HT29 | viability after 13 days | TAATGCTTGCCCATCACCTCGG | RNF112 | ENSG00000128482 | -0.10863127345202817 | [358,279] | [362,423,249] | -1 | hSpCas9 | negative selection | 5269626 | 19414594 | 19414616 | 17 | - | 27760321 | HT29 | viability after 13 days | GGATGAGTCACGAACTAAGAGG | RNF112 | ENSG00000128482 | -0.034201942178949896 | [143,112] | [157,118,158] | 0 | hSpCas9 | negative selection | 5269627 | 19413354 | 19413376 | 17 | + | 27760321 | HT29 | viability after 10 days | CGCCAGGGGCATATGGATGTGG | RNF112 | ENSG00000128482 | 0.3756290731799268 | [391,305] | [436,663,596] | 5 | hSpCas9 | negative selection | 5353088 | 19414465 | 19414487 | 17 | - | 27760321 | HT29 | viability after 10 days | TAATGCTTGCCCATCACCTCGG | RNF112 | ENSG00000128482 | -0.15380781275811234 | [358,279] | [304,289,475] | -2 | hSpCas9 | negative selection | 5353089 | 19414594 | 19414616 | 17 | - | 27760321 | HT29 | viability after 10 days | GGATGAGTCACGAACTAAGAGG | RNF112 | ENSG00000128482 | 0.3678223637872684 | [143,112] | [203,162,251] | 5 | hSpCas9 | negative selection | 5353090 | 19413354 | 19413376 | 17 | + | 27760321 | MOLM13 | viability | CGCCAGGGGCATATGGATGTGG | RNF112 | ENSG00000128482 | 0.6652722251703453 | [465,391] | [430,340] | 4 | hSpCas9 | negative selection | 5436551 | 19414465 | 19414487 | 17 | - | 27760321 | MOLM13 | viability | TAATGCTTGCCCATCACCTCGG | RNF112 | ENSG00000128482 | 0.6458238152157255 | [450,358] | [94,576] | 4 | hSpCas9 | negative selection | 5436552 | 19414594 | 19414616 | 17 | - | 27760321 | MOLM13 | viability | GGATGAGTCACGAACTAAGAGG | RNF112 | ENSG00000128482 | 0.6602446990107554 | [210,143] | [50,245] | 4 | hSpCas9 | negative selection | 5436553 | 19411251 | 19411274 | 17 | + | 27661255 | K562 | viability | GACCGGGAGTCAGCTCCTCGGGG | RNF112 | ENSG00000128482 | 0.5407780129476445 | [282,318] | [368,331] | 9 | dCas9-KRAB | negative selection | 5507746 | 19411550 | 19411573 | 17 | + | 27661255 | K562 | viability | GAGGGGTCCCTGGAAATCCAGGG | RNF112 | ENSG00000128482 | 0.09001001415123411 | [1287,1456] | [1294,1052] | 3 | dCas9-KRAB | negative selection | 5507747 | 19411266 | 19411289 | 17 | - | 27661255 | K562 | viability | GTCGGGGGATGGTATCCCCGAGG | RNF112 | ENSG00000128482 | -0.11496841105334865 | [287,262] | [229,180] | -4 | dCas9-KRAB | negative selection | 5507748 | 19411282 | 19411305 | 17 | - | 27661255 | K562 | viability | GTAGGTAGAAGGTGAGGTCGGGG | RNF112 | ENSG00000128482 | 0.11263436430302359 | [630,651] | [631,486] | 4 | dCas9-KRAB | negative selection | 5507749 | 19411339 | 19411362 | 17 | - | 27661255 | K562 | viability | GAGACCTTCAACCAGAGGTAAGG | RNF112 | ENSG00000128482 | -0.044034418967709876 | [383,476] | [382,288] | -2 | dCas9-KRAB | negative selection | 5507750 | 19413340 | 19413363 | 17 | + | 27260156 | BXPC3 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | -0.09621987426995202 | [467] | [356,399,468,638] | -2 | hSpCas9 | negative selection | 5567561 | 19413356 | 19413379 | 17 | - | 27260156 | BXPC3 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.23865072192387315 | [1821] | [1478,1554,1555,1910] | -5 | hSpCas9 | negative selection | 5631814 | 19411629 | 19411652 | 17 | + | 27260156 | BXPC3 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.21777180684389852 | [269] | [325,233,327,442] | 5 | hSpCas9 | negative selection | 5631815 | 19413340 | 19413363 | 17 | + | 27260156 | A673 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | 0.13954235692875672 | [467] | [553,675,657,574] | 3 | hSpCas9 | negative selection | 5688812 | 19413356 | 19413379 | 17 | - | 27260156 | A673 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.0901150221658491 | [1821] | [2387,1796,2012,2064] | -2 | hSpCas9 | negative selection | 5753065 | 19411629 | 19411652 | 17 | + | 27260156 | A673 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.2052830272090257 | [269] | [484,406,321,287] | 5 | hSpCas9 | negative selection | 5753066 | 19413340 | 19413363 | 17 | + | 27260156 | A375 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | 0.11578601233048888 | [467] | [662,543,665,498] | 1 | hSpCas9 | negative selection | 5810063 | 19413356 | 19413379 | 17 | - | 27260156 | A375 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.18575329318472034 | [1821] | [1846,2007,1570,2047] | -3 | hSpCas9 | negative selection | 5874316 | 19411629 | 19411652 | 17 | + | 27260156 | A375 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.48177783351802905 | [269] | [388,571,387,429] | 7 | hSpCas9 | negative selection | 5874317 | 19413340 | 19413363 | 17 | + | 27260156 | COLO741 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | 0.06206944903950917 | [467] | [628,607,633] | 1 | hSpCas9 | negative selection | 5931314 | 19413356 | 19413379 | 17 | - | 27260156 | COLO741 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | 0.03543187370786027 | [1821] | [2621,2222,2330] | 0 | hSpCas9 | negative selection | 5995567 | 19411629 | 19411652 | 17 | + | 27260156 | COLO741 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.49849009364559954 | [269] | [339,623,484] | 8 | hSpCas9 | negative selection | 5995568 | 19413340 | 19413363 | 17 | + | 27260156 | CAL120 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | 0.4379886373464765 | [467] | [513,1404,412] | 6 | hSpCas9 | negative selection | 6052565 | 19413356 | 19413379 | 17 | - | 27260156 | CAL120 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.18435167222262772 | [1821] | [2312,2066,1658] | -3 | hSpCas9 | negative selection | 6116818 | 19411629 | 19411652 | 17 | + | 27260156 | CAL120 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.22221437280022271 | [269] | [491,267,429] | 3 | hSpCas9 | negative selection | 6116819 | 19413340 | 19413363 | 17 | + | 27260156 | CADOES1 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | -0.08316663636844429 | [467] | [434,468,318,420] | -1 | hSpCas9 | negative selection | 6173816 | 19413356 | 19413379 | 17 | - | 27260156 | CADOES1 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.13650666005139533 | [1821] | [1421,1501,1458,1792] | -2 | hSpCas9 | negative selection | 6238069 | 19411629 | 19411652 | 17 | + | 27260156 | CADOES1 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.39141252513035774 | [269] | [304,267,349,396] | 6 | hSpCas9 | negative selection | 6238070 | 19413340 | 19413363 | 17 | + | 27260156 | EWS502 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | 0.13509319748654683 | [467] | [659,392,502,615] | 2 | hSpCas9 | negative selection | 6295067 | 19413356 | 19413379 | 17 | - | 27260156 | EWS502 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | 0.134255437499343 | [1821] | [1978,2178,2242,2075] | 2 | hSpCas9 | negative selection | 6359320 | 19411629 | 19411652 | 17 | + | 27260156 | EWS502 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.4257172037392564 | [269] | [405,321,414,392] | 7 | hSpCas9 | negative selection | 6359321 | 19413340 | 19413363 | 17 | + | 27260156 | EW8 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | 0.383606987129349 | [467] | [489,578,445,470] | 7 | hSpCas9 | negative selection | 6416318 | 19413356 | 19413379 | 17 | - | 27260156 | EW8 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | 0.094749002122966 | [1821] | [2050,1582,1445,1297] | 1 | hSpCas9 | negative selection | 6480571 | 19411629 | 19411652 | 17 | + | 27260156 | EW8 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.254487369883714 | [269] | [185,256,199,401] | 4 | hSpCas9 | negative selection | 6480572 | 19413340 | 19413363 | 17 | + | 27260156 | CORL105 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | 0.17749850702397477 | [467] | [646,681,548,588] | 3 | hSpCas9 | negative selection | 6537569 | 19413356 | 19413379 | 17 | - | 27260156 | CORL105 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.1254003700234121 | [1821] | [1777,1606,2545,1982] | -2 | hSpCas9 | negative selection | 6601822 | 19411629 | 19411652 | 17 | + | 27260156 | CORL105 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.643062401303113 | [269] | [606,374,671,354] | 9 | hSpCas9 | negative selection | 6601823 | 19413340 | 19413363 | 17 | + | 27260156 | HS294T | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | 0.039443697092496 | [467] | [140,189,157,272] | 0 | hSpCas9 | negative selection | 6658820 | 19413356 | 19413379 | 17 | - | 27260156 | HS294T | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | 0.21488021144063296 | [1821] | [796,584,776,1178] | 3 | hSpCas9 | negative selection | 6723073 | 19411629 | 19411652 | 17 | + | 27260156 | HS294T | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.6037349480701633 | [269] | [207,166,114,134] | 7 | hSpCas9 | negative selection | 6723074 | 19413340 | 19413363 | 17 | + | 27260156 | HCC44 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | -0.3609768448077602 | [467] | [501,292,523,371] | -5 | hSpCas9 | negative selection | 6780071 | 19413356 | 19413379 | 17 | - | 27260156 | HCC44 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.3988423210881251 | [1821] | [1532,1513,1939,1328] | -6 | hSpCas9 | negative selection | 6844324 | 19411629 | 19411652 | 17 | + | 27260156 | HCC44 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.37857268581627895 | [269] | [451,358,499,304] | 6 | hSpCas9 | negative selection | 6844325 | 19413340 | 19413363 | 17 | + | 27260156 | G402 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | -0.41277486473884023 | [467] | [654,279,518,290] | -5 | hSpCas9 | negative selection | 6901322 | 19413356 | 19413379 | 17 | - | 27260156 | G402 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.20884553120566962 | [1821] | [2538,1658,2139,1445] | -3 | hSpCas9 | negative selection | 6965575 | 19411629 | 19411652 | 17 | + | 27260156 | G402 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.4933088278941988 | [269] | [443,237,494,650] | 6 | hSpCas9 | negative selection | 6965576 | 19413340 | 19413363 | 17 | + | 27260156 | L33 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | 0.15843540809377724 | [467] | [688,196,293,447] | 3 | hSpCas9 | negative selection | 7022573 | 19413356 | 19413379 | 17 | - | 27260156 | L33 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.0192362539369475 | [1821] | [1621,710,1089,2100] | 0 | hSpCas9 | negative selection | 7086826 | 19411629 | 19411652 | 17 | + | 27260156 | L33 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | -0.010424563469585424 | [269] | [209,133,164,273] | 0 | hSpCas9 | negative selection | 7086827 | 19413340 | 19413363 | 17 | + | 27260156 | K562 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | -0.2664214787365677 | [467] | [316,274,316,451] | -3 | hSpCas9 | negative selection | 7143824 | 19413356 | 19413379 | 17 | - | 27260156 | K562 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.08826216555043631 | [1821] | [1851,1956,1143,1210] | -1 | hSpCas9 | negative selection | 7208077 | 19411629 | 19411652 | 17 | + | 27260156 | K562 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.9027021391308285 | [269] | [127,686,472,483] | 9 | hSpCas9 | negative selection | 7208078 | 19413340 | 19413363 | 17 | + | 27260156 | HT29 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | 0.1037634574551279 | [467] | [720,637,520,575] | 2 | hSpCas9 | negative selection | 7265075 | 19413356 | 19413379 | 17 | - | 27260156 | HT29 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.024733896611766282 | [1821] | [2204,2273,2142,2091] | 0 | hSpCas9 | negative selection | 7329328 | 19411629 | 19411652 | 17 | + | 27260156 | HT29 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.1011289794677781 | [269] | [422,462,266,276] | 2 | hSpCas9 | negative selection | 7329329 | 19413340 | 19413363 | 17 | + | 27260156 | MHHES1 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | 0.0344187106407082 | [467] | [407,591,533,589] | 0 | hSpCas9 | negative selection | 7386326 | 19413356 | 19413379 | 17 | - | 27260156 | MHHES1 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.17668690900871864 | [1821] | [2130,2171,1774,1330] | -3 | hSpCas9 | negative selection | 7450579 | 19411629 | 19411652 | 17 | + | 27260156 | MHHES1 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.5141508340823149 | [269] | [413,289,623,392] | 8 | hSpCas9 | negative selection | 7450580 | 19413340 | 19413363 | 17 | + | 27260156 | MEWO | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | -0.13834154149627306 | [467] | [475,291,440] | -3 | hSpCas9 | negative selection | 7507577 | 19413356 | 19413379 | 17 | - | 27260156 | MEWO | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | 0.023118359394461496 | [1821] | [1862,1599,1758] | 0 | hSpCas9 | negative selection | 7571830 | 19411629 | 19411652 | 17 | + | 27260156 | MEWO | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.09724368794410143 | [269] | [331,178,311] | 2 | hSpCas9 | negative selection | 7571831 | 19413340 | 19413363 | 17 | + | 27260156 | LNCAPCLONEFGC | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | 0.01835794697200795 | [467] | [501,351,510,367] | 0 | hSpCas9 | negative selection | 7628828 | 19413356 | 19413379 | 17 | - | 27260156 | LNCAPCLONEFGC | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.08066902209939864 | [1821] | [1690,1440,1754,1388] | -1 | hSpCas9 | negative selection | 7693081 | 19411629 | 19411652 | 17 | + | 27260156 | LNCAPCLONEFGC | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.5196113674999437 | [269] | [266,407,376,351] | 7 | hSpCas9 | negative selection | 7693082 | 19413340 | 19413363 | 17 | + | 27260156 | PANC0327 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | -0.5486863046979069 | [467] | [347,159,299,349] | -7 | hSpCas9 | negative selection | 7750079 | 19413356 | 19413379 | 17 | - | 27260156 | PANC0327 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.08157708489023818 | [1821] | [2026,1922,1017,1138] | -1 | hSpCas9 | negative selection | 7814332 | 19411629 | 19411652 | 17 | + | 27260156 | PANC0327 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.3408777469669051 | [269] | [250,338,261,353] | 5 | hSpCas9 | negative selection | 7814333 | 19413340 | 19413363 | 17 | + | 27260156 | NCIH2009 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | -0.007969296254389299 | [467] | [864,602,524] | 0 | hSpCas9 | negative selection | 7871330 | 19413356 | 19413379 | 17 | - | 27260156 | NCIH2009 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | 0.0454417973526815 | [1821] | [2841,2640,2435] | 0 | hSpCas9 | negative selection | 7935583 | 19411629 | 19411652 | 17 | + | 27260156 | NCIH2009 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.5758817615575422 | [269] | [597,506,588] | 7 | hSpCas9 | negative selection | 7935584 | 19413340 | 19413363 | 17 | + | 27260156 | NCIH1373 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | -0.9898395492088249 | [467] | [194,326,378,32] | -7 | hSpCas9 | negative selection | 7992581 | 19413356 | 19413379 | 17 | - | 27260156 | NCIH1373 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.33403516277150924 | [1821] | [1808,1400,1555,464] | -3 | hSpCas9 | negative selection | 8056834 | 19411629 | 19411652 | 17 | + | 27260156 | NCIH1373 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.6896513545801348 | [269] | [681,300,609,104] | 7 | hSpCas9 | negative selection | 8056835 | 19413340 | 19413363 | 17 | + | 27260156 | PATU8902 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | -0.6144469192099382 | [467] | [388,686,325,310] | -5 | hSpCas9 | negative selection | 8113832 | 19413356 | 19413379 | 17 | - | 27260156 | PATU8902 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.26088432435808606 | [1821] | [1686,2116,1571,3375] | -3 | hSpCas9 | negative selection | 8178085 | 19411629 | 19411652 | 17 | + | 27260156 | PATU8902 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.49978718549091977 | [269] | [743,728,136,623] | 5 | hSpCas9 | negative selection | 8178086 | 19413340 | 19413363 | 17 | + | 27260156 | PANC1 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | -0.5839849185762472 | [467] | [207,236,358,260] | -7 | hSpCas9 | negative selection | 8235083 | 19413356 | 19413379 | 17 | - | 27260156 | PANC1 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.23099437779617804 | [1821] | [1404,1498,1291,1173] | -4 | hSpCas9 | negative selection | 8299336 | 19411629 | 19411652 | 17 | + | 27260156 | PANC1 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.22410635792685107 | [269] | [325,307,307,161] | 3 | hSpCas9 | negative selection | 8299337 | 19413340 | 19413363 | 17 | + | 27260156 | PANC0813 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | 0.38567221020166204 | [467] | [761,983,580,556] | 6 | hSpCas9 | negative selection | 8356334 | 19413356 | 19413379 | 17 | - | 27260156 | PANC0813 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | 0.15155053638282467 | [1821] | [2450,2607,2086,2364] | 2 | hSpCas9 | negative selection | 8420587 | 19411629 | 19411652 | 17 | + | 27260156 | PANC0813 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.4617516317068339 | [269] | [317,306,405,689] | 7 | hSpCas9 | negative selection | 8420588 | 19413340 | 19413363 | 17 | + | 27260156 | RDES | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | -0.09179509693661571 | [467] | [588,369,455,592] | -1 | hSpCas9 | negative selection | 8477585 | 19413356 | 19413379 | 17 | - | 27260156 | RDES | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.035590765513474176 | [1821] | [1717,1805,2189,2581] | 0 | hSpCas9 | negative selection | 8541838 | 19411629 | 19411652 | 17 | + | 27260156 | RDES | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.2999311103217043 | [269] | [368,399,359,387] | 5 | hSpCas9 | negative selection | 8541839 | 19413340 | 19413363 | 17 | + | 27260156 | PC3 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | -0.17656421434244998 | [467] | [367,347,656,337] | -4 | hSpCas9 | negative selection | 8598836 | 19413356 | 19413379 | 17 | - | 27260156 | PC3 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.15170356558794174 | [1821] | [1113,1630,2412,1744] | -3 | hSpCas9 | negative selection | 8663089 | 19411629 | 19411652 | 17 | + | 27260156 | PC3 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.3077689655297328 | [269] | [286,286,607,232] | 6 | hSpCas9 | negative selection | 8663090 | 19413340 | 19413363 | 17 | + | 27260156 | PATU8988T | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | 0.010311411645840629 | [467] | [337,315,435,741] | 0 | hSpCas9 | negative selection | 8720087 | 19413356 | 19413379 | 17 | - | 27260156 | PATU8988T | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | 0.006745151965253271 | [1821] | [1718,1942,1601,1834] | 0 | hSpCas9 | negative selection | 8784340 | 19411629 | 19411652 | 17 | + | 27260156 | PATU8988T | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.8855869052259508 | [269] | [222,437,617,656] | 9 | hSpCas9 | negative selection | 8784341 | 19413340 | 19413363 | 17 | + | 27260156 | T47D | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | -0.46110648802883963 | [467] | [422,290,461,416] | -7 | hSpCas9 | negative selection | 8841338 | 19413356 | 19413379 | 17 | - | 27260156 | T47D | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.2542171551383696 | [1821] | [1998,1617,1732,1783] | -5 | hSpCas9 | negative selection | 8905591 | 19411629 | 19411652 | 17 | + | 27260156 | T47D | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.36225006035994145 | [269] | [420,471,370,345] | 7 | hSpCas9 | negative selection | 8905592 | 19413340 | 19413363 | 17 | + | 27260156 | SU8686 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | 0.2764189635860722 | [467] | [557,506,520,683] | 5 | hSpCas9 | negative selection | 8962589 | 19413356 | 19413379 | 17 | - | 27260156 | SU8686 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.037150338817110606 | [1821] | [1525,1600,2129,1842] | 0 | hSpCas9 | negative selection | 9026842 | 19411629 | 19411652 | 17 | + | 27260156 | SU8686 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.5637834479746644 | [269] | [455,283,384,474] | 8 | hSpCas9 | negative selection | 9026843 | 19413340 | 19413363 | 17 | + | 27260156 | SKES1 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | 0.21305576148646102 | [467] | [672,438,634,429] | 4 | hSpCas9 | negative selection | 9083840 | 19413356 | 19413379 | 17 | - | 27260156 | SKES1 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.34776775184603204 | [1821] | [1425,1553,1336,1399] | -6 | hSpCas9 | negative selection | 9148093 | 19411629 | 19411652 | 17 | + | 27260156 | SKES1 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.22665555003178195 | [269] | [300,325,432,207] | 5 | hSpCas9 | negative selection | 9148094 | 19413340 | 19413363 | 17 | + | 27260156 | TOV112D | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | -0.14818640294544957 | [467] | [331,599,368,425] | -3 | hSpCas9 | negative selection | 9205091 | 19413356 | 19413379 | 17 | - | 27260156 | TOV112D | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.1952480959312799 | [1821] | [1988,1747,1368,1344] | -4 | hSpCas9 | negative selection | 9269344 | 19411629 | 19411652 | 17 | + | 27260156 | TOV112D | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.3935860718755357 | [269] | [257,579,292,336] | 7 | hSpCas9 | negative selection | 9269345 | 19413340 | 19413363 | 17 | + | 27260156 | TC71 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | -0.06162787279055647 | [467] | [414,436,514,560] | -1 | hSpCas9 | negative selection | 9326342 | 19413356 | 19413379 | 17 | - | 27260156 | TC71 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | -0.1321042456078192 | [1821] | [1766,1769,1818,1770] | -3 | hSpCas9 | negative selection | 9390595 | 19411629 | 19411652 | 17 | + | 27260156 | TC71 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.2003799230720439 | [269] | [306,302,395,321] | 5 | hSpCas9 | negative selection | 9390596 | 19413340 | 19413363 | 17 | + | 27260156 | TC32 | viability | GGCGCCAATGGCCTCGCCAGGGG | RNF112 | ENSG00000128482 | -0.09944288965795722 | [467] | [299,340,491,546] | -2 | hSpCas9 | negative selection | 9447593 | 19413356 | 19413379 | 17 | - | 27260156 | TC32 | viability | GCTCCACATCCATATGCCCCTGG | RNF112 | ENSG00000128482 | 0.05896008814888054 | [1821] | [1550,1670,2198,1741] | 1 | hSpCas9 | negative selection | 9511846 | 19411629 | 19411652 | 17 | + | 27260156 | TC32 | viability | GGAGAGAAAACAGAGCTTCATGG | RNF112 | ENSG00000128482 | 0.31225787152908857 | [269] | [276,224,413,385] | 5 | hSpCas9 | negative selection | 9511847 | 19413580 | 19413603 | 17 | + | 27869803 | HPAFII | viability after 27 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | -0.5755216359185703 | [326] | [146,88,NaN] | -4 | hSpCas9 | negative selection | 9559501 | 19414112 | 19414135 | 17 | + | 27869803 | HPAFII | viability after 27 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | -0.9452865589439362 | [299] | [100,65,NaN] | -6 | hSpCas9 | negative selection | 9559502 | 19414472 | 19414495 | 17 | + | 27869803 | HPAFII | viability after 27 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | -1.0687470064135371 | [106] | [34,19,NaN] | -6 | hSpCas9 | negative selection | 9559503 | 19414848 | 19414871 | 17 | + | 27869803 | HPAFII | viability after 27 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | 0.22247377402619928 | [94] | [66,50,NaN] | 1 | hSpCas9 | negative selection | 9559504 | 19413580 | 19413603 | 17 | + | 27869803 | HPAFII | viability after 15 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | 0.30823088966267387 | [326] | [555,359,NaN] | 3 | hSpCas9 | negative selection | 9641950 | 19414112 | 19414135 | 17 | + | 27869803 | HPAFII | viability after 15 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | -0.40837912400782267 | [299] | [237,245,NaN] | -4 | hSpCas9 | negative selection | 9641951 | 19414472 | 19414495 | 17 | + | 27869803 | HPAFII | viability after 15 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | -0.11161746598128364 | [106] | [119,97,NaN] | -1 | hSpCas9 | negative selection | 9641952 | 19414848 | 19414871 | 17 | + | 27869803 | HPAFII | viability after 15 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | 0.04922496978274715 | [94] | [207,41,NaN] | 0 | hSpCas9 | negative selection | 9641953 | 19413580 | 19413603 | 17 | + | 27869803 | ASPC1 | viability after 36 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | 0.35416744049710147 | [942] | [290,550,403] | 3 | hSpCas9 | negative selection | 9724399 | 19414112 | 19414135 | 17 | + | 27869803 | ASPC1 | viability after 36 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | -0.02756928450104787 | [712] | [409,207,153] | 0 | hSpCas9 | negative selection | 9724400 | 19414472 | 19414495 | 17 | + | 27869803 | ASPC1 | viability after 36 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | 0.3066085927082338 | [206] | [75,39,136] | 3 | hSpCas9 | negative selection | 9724401 | 19414848 | 19414871 | 17 | + | 27869803 | ASPC1 | viability after 36 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | 0.06185691412672223 | [399] | [180,197,77] | 0 | hSpCas9 | negative selection | 9724402 | 19413580 | 19413603 | 17 | + | 27869803 | PATU8988S | viability after 35 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | 0.43394156592744415 | [914] | [425,569,NaN] | 5 | hSpCas9 | negative selection | 9806848 | 19414112 | 19414135 | 17 | + | 27869803 | PATU8988S | viability after 35 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | 0.35375269077898025 | [504] | [218,300,NaN] | 4 | hSpCas9 | negative selection | 9806849 | 19414472 | 19414495 | 17 | + | 27869803 | PATU8988S | viability after 35 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | -0.232009354961348 | [200] | [36,100,NaN] | -2 | hSpCas9 | negative selection | 9806850 | 19414848 | 19414871 | 17 | + | 27869803 | PATU8988S | viability after 35 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | -0.08274813248258572 | [371] | [128,153,NaN] | -1 | hSpCas9 | negative selection | 9806851 | 19413580 | 19413603 | 17 | + | 27869803 | PATU8988S | viability after 31 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | 0.1960966441276153 | [914] | [274,599,NaN] | 2 | hSpCas9 | negative selection | 9889297 | 19414112 | 19414135 | 17 | + | 27869803 | PATU8988S | viability after 31 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | 0.17003423251103472 | [504] | [193,267,NaN] | 2 | hSpCas9 | negative selection | 9889298 | 19414472 | 19414495 | 17 | + | 27869803 | PATU8988S | viability after 31 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | -0.7421459229836209 | [200] | [28,71,NaN] | -7 | hSpCas9 | negative selection | 9889299 | 19414848 | 19414871 | 17 | + | 27869803 | PATU8988S | viability after 31 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | -0.3607584842510789 | [371] | [89,147,NaN] | -4 | hSpCas9 | negative selection | 9889300 | 19413580 | 19413603 | 17 | + | 27869803 | HPAFII | viability after 35 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | -0.27861448164922514 | [326] | [135,136,NaN] | -2 | hSpCas9 | negative selection | 9971746 | 19414112 | 19414135 | 17 | + | 27869803 | HPAFII | viability after 35 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | -0.29216598033805613 | [299] | [68,185,NaN] | -2 | hSpCas9 | negative selection | 9971747 | 19414472 | 19414495 | 17 | + | 27869803 | HPAFII | viability after 35 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | -3.339359984523785 | [106] | [2,7,NaN] | -8 | hSpCas9 | negative selection | 9971748 | 19414848 | 19414871 | 17 | + | 27869803 | HPAFII | viability after 35 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | -1.1437097368777043 | [94] | [25,16,NaN] | -6 | hSpCas9 | negative selection | 9971749 | 19413580 | 19413603 | 17 | + | 27869803 | HPAFII | viability after 31 days | GCGGTGTTCCTGGTGGACACAGG | RNF112 | ENSG00000128482 | -0.08753201863130533 | [326] | [143,203,NaN] | 0 | hSpCas9 | negative selection | 10054195 | 19414112 | 19414135 | 17 | + | 27869803 | HPAFII | viability after 31 days | GGAGCTGAAGGATACAGACCTGG | RNF112 | ENSG00000128482 | -0.41343179350732795 | [299] | [90,164,NaN] | -3 | hSpCas9 | negative selection | 10054196 | 19414472 | 19414495 | 17 | + | 27869803 | HPAFII | viability after 31 days | GATGGGCAAGCATTATGGGATGG | RNF112 | ENSG00000128482 | -0.9642414205604732 | [106] | [36,23,NaN] | -6 | hSpCas9 | negative selection | 10054197 | 19414848 | 19414871 | 17 | + | 27869803 | HPAFII | viability after 31 days | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | -1.3649255460437277 | [94] | [13,27,NaN] | -7 | hSpCas9 | negative selection | 10054198 | 19411419 | 19411442 | 17 | - | 28162770 | P31FUJ | viability | AAAGGAAGTGACTGACAAGGCGG | RNF112 | ENSG00000128482 | 0.371408180900056 | [272] | [414] | 4 | hSpCas9 | negative selection | 10225987 | 19413582 | 19413605 | 17 | + | 28162770 | P31FUJ | viability | GGTGTTCCTGGTGGACACAGGGG | RNF112 | ENSG00000128482 | -2.238340387955809 | [260] | [64] | -8 | hSpCas9 | negative selection | 10225988 | 19414848 | 19414871 | 17 | + | 28162770 | P31FUJ | viability | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | -0.6821096057779688 | [141] | [103] | -5 | hSpCas9 | negative selection | 10225989 | 19415186 | 19415209 | 17 | + | 28162770 | P31FUJ | viability | GCAGCTAGCTCAGGAAATCAAGG | RNF112 | ENSG00000128482 | 1.8826750130055574 | [77] | [337] | 9 | hSpCas9 | negative selection | 10225990 | 19411406 | 19411429 | 17 | - | 28162770 | P31FUJ | viability | GACAAGGCGGGCCTTGGCATGGG | RNF112 | ENSG00000128482 | 0.2477527057886727 | [338] | [472] | 2 | hSpCas9 | negative selection | 10225991 | 19411419 | 19411442 | 17 | - | 28162770 | TF1 | viability | AAAGGAAGTGACTGACAAGGCGG | RNF112 | ENSG00000128482 | NaN | [NaN] | [334] | 1 | hSpCas9 | negative selection | 10395353 | 19413582 | 19413605 | 17 | + | 28162770 | TF1 | viability | GGTGTTCCTGGTGGACACAGGGG | RNF112 | ENSG00000128482 | NaN | [NaN] | [68] | 1 | hSpCas9 | negative selection | 10395354 | 19414848 | 19414871 | 17 | + | 28162770 | TF1 | viability | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | NaN | [NaN] | [71] | 1 | hSpCas9 | negative selection | 10395355 | 19415186 | 19415209 | 17 | + | 28162770 | TF1 | viability | GCAGCTAGCTCAGGAAATCAAGG | RNF112 | ENSG00000128482 | NaN | [NaN] | [44] | 1 | hSpCas9 | negative selection | 10395356 | 19411406 | 19411429 | 17 | - | 28162770 | TF1 | viability | GACAAGGCGGGCCTTGGCATGGG | RNF112 | ENSG00000128482 | NaN | [NaN] | [215] | 1 | hSpCas9 | negative selection | 10395357 | 19411419 | 19411442 | 17 | - | 28162770 | SKM1 | viability | AAAGGAAGTGACTGACAAGGCGG | RNF112 | ENSG00000128482 | -0.4036890667103007 | [109] | [146] | -3 | hSpCas9 | negative selection | 10564719 | 19413582 | 19413605 | 17 | + | 28162770 | SKM1 | viability | GGTGTTCCTGGTGGACACAGGGG | RNF112 | ENSG00000128482 | -1.2225396276057343 | [98] | [74] | -7 | hSpCas9 | negative selection | 10564720 | 19414848 | 19414871 | 17 | + | 28162770 | SKM1 | viability | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | -2.069929211465591 | [37] | [15] | -8 | hSpCas9 | negative selection | 10564721 | 19415186 | 19415209 | 17 | + | 28162770 | SKM1 | viability | GCAGCTAGCTCAGGAAATCAAGG | RNF112 | ENSG00000128482 | -0.5589672921882118 | [9] | [11] | -4 | hSpCas9 | negative selection | 10564722 | 19411406 | 19411429 | 17 | - | 28162770 | SKM1 | viability | GACAAGGCGGGCCTTGGCATGGG | RNF112 | ENSG00000128482 | 0.43383720640758444 | [66] | [159] | 4 | hSpCas9 | negative selection | 10564723 | 19411419 | 19411442 | 17 | - | 28162770 | SKM1 | viability | AAAGGAAGTGACTGACAAGGCGG | RNF112 | ENSG00000128482 | -0.4036890667103007 | [109] | [146] | -3 | hSpCas9 | negative selection | 10734085 | 19413582 | 19413605 | 17 | + | 28162770 | SKM1 | viability | GGTGTTCCTGGTGGACACAGGGG | RNF112 | ENSG00000128482 | -1.2225396276057343 | [98] | [74] | -7 | hSpCas9 | negative selection | 10734086 | 19414848 | 19414871 | 17 | + | 28162770 | SKM1 | viability | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | -2.069929211465591 | [37] | [15] | -8 | hSpCas9 | negative selection | 10734087 | 19415186 | 19415209 | 17 | + | 28162770 | SKM1 | viability | GCAGCTAGCTCAGGAAATCAAGG | RNF112 | ENSG00000128482 | -0.5589672921882118 | [9] | [11] | -4 | hSpCas9 | negative selection | 10734088 | 19411406 | 19411429 | 17 | - | 28162770 | SKM1 | viability | GACAAGGCGGGCCTTGGCATGGG | RNF112 | ENSG00000128482 | 0.43383720640758444 | [66] | [159] | 4 | hSpCas9 | negative selection | 10734089 | 19411419 | 19411442 | 17 | - | 28162770 | PL21 | viability | AAAGGAAGTGACTGACAAGGCGG | RNF112 | ENSG00000128482 | 0.7916036811524316 | [368] | [277] | 6 | hSpCas9 | negative selection | 10903451 | 19413582 | 19413605 | 17 | + | 28162770 | PL21 | viability | GGTGTTCCTGGTGGACACAGGGG | RNF112 | ENSG00000128482 | 0.5532493646249621 | [237] | [151] | 5 | hSpCas9 | negative selection | 10903452 | 19414848 | 19414871 | 17 | + | 28162770 | PL21 | viability | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | 0.3770173765733995 | [91] | [51] | 3 | hSpCas9 | negative selection | 10903453 | 19415186 | 19415209 | 17 | + | 28162770 | PL21 | viability | GCAGCTAGCTCAGGAAATCAAGG | RNF112 | ENSG00000128482 | -0.3023607260398631 | [33] | [11] | -2 | hSpCas9 | negative selection | 10903454 | 19411406 | 19411429 | 17 | - | 28162770 | PL21 | viability | GACAAGGCGGGCCTTGGCATGGG | RNF112 | ENSG00000128482 | 0.48338724121262266 | [188] | [114] | 4 | hSpCas9 | negative selection | 10903455 | 19411419 | 19411442 | 17 | - | 28162770 | P31FUJ | viability | AAAGGAAGTGACTGACAAGGCGG | RNF112 | ENSG00000128482 | 0.371408180900056 | [272] | [414] | 4 | hSpCas9 | negative selection | 11072817 | 19413582 | 19413605 | 17 | + | 28162770 | P31FUJ | viability | GGTGTTCCTGGTGGACACAGGGG | RNF112 | ENSG00000128482 | -2.238340387955809 | [260] | [64] | -8 | hSpCas9 | negative selection | 11072818 | 19414848 | 19414871 | 17 | + | 28162770 | P31FUJ | viability | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | -0.6821096057779688 | [141] | [103] | -5 | hSpCas9 | negative selection | 11072819 | 19415186 | 19415209 | 17 | + | 28162770 | P31FUJ | viability | GCAGCTAGCTCAGGAAATCAAGG | RNF112 | ENSG00000128482 | 1.8826750130055574 | [77] | [337] | 9 | hSpCas9 | negative selection | 11072820 | 19411406 | 19411429 | 17 | - | 28162770 | P31FUJ | viability | GACAAGGCGGGCCTTGGCATGGG | RNF112 | ENSG00000128482 | 0.2477527057886727 | [338] | [472] | 2 | hSpCas9 | negative selection | 11072821 | 19411419 | 19411442 | 17 | - | 28162770 | OCIAML5 | viability | AAAGGAAGTGACTGACAAGGCGG | RNF112 | ENSG00000128482 | 0.9687401506622151 | [121] | [430] | 8 | hSpCas9 | negative selection | 11242183 | 19413582 | 19413605 | 17 | + | 28162770 | OCIAML5 | viability | GGTGTTCCTGGTGGACACAGGGG | RNF112 | ENSG00000128482 | -1.1562199640233832 | [120] | [97] | -6 | hSpCas9 | negative selection | 11242184 | 19414848 | 19414871 | 17 | + | 28162770 | OCIAML5 | viability | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | 0.25645788591417207 | [63] | [137] | 2 | hSpCas9 | negative selection | 11242185 | 19415186 | 19415209 | 17 | + | 28162770 | OCIAML5 | viability | GCAGCTAGCTCAGGAAATCAAGG | RNF112 | ENSG00000128482 | 0.12284244817317247 | [28] | [56] | 1 | hSpCas9 | negative selection | 11242186 | 19411406 | 19411429 | 17 | - | 28162770 | OCIAML5 | viability | GACAAGGCGGGCCTTGGCATGGG | RNF112 | ENSG00000128482 | 0.011431429231140822 | [143] | [261] | 0 | hSpCas9 | negative selection | 11242187 | 19411419 | 19411442 | 17 | - | 28162770 | EOL1 | viability | AAAGGAAGTGACTGACAAGGCGG | RNF112 | ENSG00000128482 | 0.18834169047314098 | [632] | [379] | 1 | hSpCas9 | negative selection | 11411549 | 19413582 | 19413605 | 17 | + | 28162770 | EOL1 | viability | GGTGTTCCTGGTGGACACAGGGG | RNF112 | ENSG00000128482 | -1.0348102439321194 | [524] | [134] | -6 | hSpCas9 | negative selection | 11411550 | 19414848 | 19414871 | 17 | + | 28162770 | EOL1 | viability | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | -0.43802230781417384 | [143] | [55] | -3 | hSpCas9 | negative selection | 11411551 | 19415186 | 19415209 | 17 | + | 28162770 | EOL1 | viability | GCAGCTAGCTCAGGAAATCAAGG | RNF112 | ENSG00000128482 | 0.5588982992538543 | [66] | [51] | 5 | hSpCas9 | negative selection | 11411552 | 19411406 | 19411429 | 17 | - | 28162770 | EOL1 | viability | GACAAGGCGGGCCTTGGCATGGG | RNF112 | ENSG00000128482 | -0.43644988799542017 | [261] | [101] | -3 | hSpCas9 | negative selection | 11411553 | 19411419 | 19411442 | 17 | - | 28162770 | MOLM13 | viability | AAAGGAAGTGACTGACAAGGCGG | RNF112 | ENSG00000128482 | 0.8718595769205857 | [457] | [605] | 6 | hSpCas9 | negative selection | 11580915 | 19413582 | 19413605 | 17 | + | 28162770 | MOLM13 | viability | GGTGTTCCTGGTGGACACAGGGG | RNF112 | ENSG00000128482 | -1.224486061597557 | [445] | [137] | -6 | hSpCas9 | negative selection | 11580916 | 19414848 | 19414871 | 17 | + | 28162770 | MOLM13 | viability | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | 0.8079648231422005 | [157] | [199] | 6 | hSpCas9 | negative selection | 11580917 | 19415186 | 19415209 | 17 | + | 28162770 | MOLM13 | viability | GCAGCTAGCTCAGGAAATCAAGG | RNF112 | ENSG00000128482 | -1.2101825235680592 | [47] | [14] | -6 | hSpCas9 | negative selection | 11580918 | 19411406 | 19411429 | 17 | - | 28162770 | MOLM13 | viability | GACAAGGCGGGCCTTGGCATGGG | RNF112 | ENSG00000128482 | -0.673771767679012 | [277] | [125] | -4 | hSpCas9 | negative selection | 11580919 | 19411419 | 19411442 | 17 | - | 28162770 | HEL | viability | AAAGGAAGTGACTGACAAGGCGG | RNF112 | ENSG00000128482 | 0.42538200056120756 | [428] | [368] | 3 | hSpCas9 | negative selection | 11750281 | 19413582 | 19413605 | 17 | + | 28162770 | HEL | viability | GGTGTTCCTGGTGGACACAGGGG | RNF112 | ENSG00000128482 | -1.0105296821117078 | [345] | [109] | -6 | hSpCas9 | negative selection | 11750282 | 19414848 | 19414871 | 17 | + | 28162770 | HEL | viability | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | 0.9958485821359988 | [118] | [151] | 8 | hSpCas9 | negative selection | 11750283 | 19415186 | 19415209 | 17 | + | 28162770 | HEL | viability | GCAGCTAGCTCAGGAAATCAAGG | RNF112 | ENSG00000128482 | -2.209703979585785 | [64] | [8] | -8 | hSpCas9 | negative selection | 11750284 | 19411406 | 19411429 | 17 | - | 28162770 | HEL | viability | GACAAGGCGGGCCTTGGCATGGG | RNF112 | ENSG00000128482 | 0.8252833199737828 | [214] | [243] | 7 | hSpCas9 | negative selection | 11750285 | 19411419 | 19411442 | 17 | - | 28162770 | MV411 | viability | AAAGGAAGTGACTGACAAGGCGG | RNF112 | ENSG00000128482 | 0.465268086765966 | [361] | [420] | 4 | hSpCas9 | negative selection | 11919647 | 19413582 | 19413605 | 17 | + | 28162770 | MV411 | viability | GGTGTTCCTGGTGGACACAGGGG | RNF112 | ENSG00000128482 | -0.2204518307618034 | [277] | [200] | -2 | hSpCas9 | negative selection | 11919648 | 19414848 | 19414871 | 17 | + | 28162770 | MV411 | viability | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | 0.7460397667007505 | [108] | [153] | 6 | hSpCas9 | negative selection | 11919649 | 19415186 | 19415209 | 17 | + | 28162770 | MV411 | viability | GCAGCTAGCTCAGGAAATCAAGG | RNF112 | ENSG00000128482 | -0.5756846871331454 | [45] | [25] | -4 | hSpCas9 | negative selection | 11919650 | 19411406 | 19411429 | 17 | - | 28162770 | MV411 | viability | GACAAGGCGGGCCTTGGCATGGG | RNF112 | ENSG00000128482 | -0.1975372326501724 | [210] | [154] | -1 | hSpCas9 | negative selection | 11919651 | 19411419 | 19411442 | 17 | - | 28162770 | MONOMAC1 | viability | AAAGGAAGTGACTGACAAGGCGG | RNF112 | ENSG00000128482 | 0.4826300776084639 | [225] | [361] | 5 | hSpCas9 | negative selection | 12089013 | 19413582 | 19413605 | 17 | + | 28162770 | MONOMAC1 | viability | GGTGTTCCTGGTGGACACAGGGG | RNF112 | ENSG00000128482 | -0.16497563782725522 | [177] | [181] | -1 | hSpCas9 | negative selection | 12089014 | 19414848 | 19414871 | 17 | + | 28162770 | MONOMAC1 | viability | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | 0.21260739344907187 | [66] | [88] | 2 | hSpCas9 | negative selection | 12089015 | 19415186 | 19415209 | 17 | + | 28162770 | MONOMAC1 | viability | GCAGCTAGCTCAGGAAATCAAGG | RNF112 | ENSG00000128482 | -0.4194292683960019 | [27] | [23] | -4 | hSpCas9 | negative selection | 12089016 | 19411406 | 19411429 | 17 | - | 28162770 | MONOMAC1 | viability | GACAAGGCGGGCCTTGGCATGGG | RNF112 | ENSG00000128482 | 0.7583730019163759 | [114] | [222] | 7 | hSpCas9 | negative selection | 12089017 | 19411419 | 19411442 | 17 | - | 28162770 | OCIAML2 | viability | AAAGGAAGTGACTGACAAGGCGG | RNF112 | ENSG00000128482 | 0.9099741769728087 | [52] | [551] | 8 | hSpCas9 | negative selection | 12258379 | 19413582 | 19413605 | 17 | + | 28162770 | OCIAML2 | viability | GGTGTTCCTGGTGGACACAGGGG | RNF112 | ENSG00000128482 | -0.7722855251032624 | [52] | [171] | -5 | hSpCas9 | negative selection | 12258380 | 19414848 | 19414871 | 17 | + | 28162770 | OCIAML2 | viability | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | -0.3775204208506797 | [14] | [63] | -3 | hSpCas9 | negative selection | 12258381 | 19415186 | 19415209 | 17 | + | 28162770 | OCIAML2 | viability | GCAGCTAGCTCAGGAAATCAAGG | RNF112 | ENSG00000128482 | -1.5377440211006979 | [10] | [20] | -7 | hSpCas9 | negative selection | 12258382 | 19411406 | 19411429 | 17 | - | 28162770 | OCIAML2 | viability | GACAAGGCGGGCCTTGGCATGGG | RNF112 | ENSG00000128482 | 0.4314437540685816 | [39] | [298] | 4 | hSpCas9 | negative selection | 12258383 | 19411419 | 19411442 | 17 | - | 28162770 | OCIAML3 | viability | AAAGGAAGTGACTGACAAGGCGG | RNF112 | ENSG00000128482 | -0.06992738175002966 | [120] | [347] | 0 | hSpCas9 | negative selection | 12427745 | 19413582 | 19413605 | 17 | + | 28162770 | OCIAML3 | viability | GGTGTTCCTGGTGGACACAGGGG | RNF112 | ENSG00000128482 | -1.5940076403241632 | [84] | [84] | -8 | hSpCas9 | negative selection | 12427746 | 19414848 | 19414871 | 17 | + | 28162770 | OCIAML3 | viability | GGGAGGCGGCGGATGAACCAAGG | RNF112 | ENSG00000128482 | 1.1129453847756035 | [33] | [221] | 8 | hSpCas9 | negative selection | 12427747 | 19415186 | 19415209 | 17 | + | 28162770 | OCIAML3 | viability | GCAGCTAGCTCAGGAAATCAAGG | RNF112 | ENSG00000128482 | 0.16087986183930547 | [15] | [53] | 1 | hSpCas9 | negative selection | 12427748 | 19411406 | 19411429 | 17 | - | 28162770 | OCIAML3 | viability | GACAAGGCGGGCCTTGGCATGGG | RNF112 | ENSG00000128482 | 0.4952596977729241 | [46] | [199] | 4 | hSpCas9 | negative selection | 12427749 |