Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:9025
• Symbol:RNF8
• Description:ring finger protein 8

DataSource: http://genomecrispr.dkfz.de/#!/results/RNF8

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
37360520	37360543	6	-	26472758	Jiyoye	viability	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	0.9546631768083667	[12]	[18]	6	hSpCas9	negative selection	138665
37368998	37369021	6	-	26472758	Jiyoye	viability	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-0.07825144566436837	[314]	[224]	0	hSpCas9	negative selection	138666
37368873	37368896	6	+	26472758	Jiyoye	viability	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	0.7325756683000406	[165]	[207]	5	hSpCas9	negative selection	138667
37371535	37371558	6	+	26472758	Jiyoye	viability	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	-0.42819391672132723	[272]	[152]	-3	hSpCas9	negative selection	138668
37376934	37376957	6	+	26472758	Jiyoye	viability	GGAGAAGATGCAAGCACAGAAGG	RNF8	ENSG00000112130	-1.84658121073991	[61]	[12]	-8	hSpCas9	negative selection	138669
37354186	37354209	6	+	26472758	Jiyoye	viability	GTCACAGGAGACCGCGCCGGTGG	RNF8	ENSG00000112130	-0.3752331834214999	[42]	[24]	-3	hSpCas9	negative selection	138670
37368574	37368597	6	-	26472758	Jiyoye	viability	GCATTCTCCTTATTTTCCAGAGG	RNF8	ENSG00000112130	-0.6112031478089813	[78]	[38]	-4	hSpCas9	negative selection	138671
37368889	37368912	6	+	26472758	Jiyoye	viability	ACAGGGGCTCCCATTTACCCTGG	RNF8	ENSG00000112130	-1.1584217943483517	[73]	[24]	-7	hSpCas9	negative selection	138672
37371517	37371540	6	+	26472758	Jiyoye	viability	GGAGATAGCCCAAGGAGAAAAGG	RNF8	ENSG00000112130	-1.7565710450073149	[232]	[51]	-8	hSpCas9	negative selection	138673
37368909	37368932	6	+	26472758	Jiyoye	viability	TGGCTTCCCCAAAGTCACAGAGG	RNF8	ENSG00000112130	-0.41448737723561424	[75]	[42]	-3	hSpCas9	negative selection	138674
37360520	37360543	6	-	26472758	KBM7	viability	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	-2.6240201915249997	[105,85]	[1,11]	-9	hSpCas9	negative selection	329783
37368998	37369021	6	-	26472758	KBM7	viability	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-0.5039738599165792	[1069,1122]	[295,428]	-4	hSpCas9	negative selection	329784
37368873	37368896	6	+	26472758	KBM7	viability	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-2.0036876638936554	[453,496]	[50,60]	-8	hSpCas9	negative selection	329785
37371535	37371558	6	+	26472758	KBM7	viability	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	0.160778644616293	[850,570]	[433,308]	1	hSpCas9	negative selection	329786
37376934	37376957	6	+	26472758	KBM7	viability	GGAGAAGATGCAAGCACAGAAGG	RNF8	ENSG00000112130	-0.5019740444093641	[140,122]	[10,72]	-4	hSpCas9	negative selection	329787
37354186	37354209	6	+	26472758	KBM7	viability	GTCACAGGAGACCGCGCCGGTGG	RNF8	ENSG00000112130	-1.4351343680203734	[132,107]	[23,17]	-7	hSpCas9	negative selection	329788
37368574	37368597	6	-	26472758	KBM7	viability	GCATTCTCCTTATTTTCCAGAGG	RNF8	ENSG00000112130	0.8528643946945087	[145,178]	[175,107]	8	hSpCas9	negative selection	329789
37368889	37368912	6	+	26472758	KBM7	viability	ACAGGGGCTCCCATTTACCCTGG	RNF8	ENSG00000112130	-0.4498651640129441	[167,117]	[46,49]	-4	hSpCas9	negative selection	329790
37371517	37371540	6	+	26472758	KBM7	viability	GGAGATAGCCCAAGGAGAAAAGG	RNF8	ENSG00000112130	-0.13024769829105418	[421,412]	[169,188]	-1	hSpCas9	negative selection	329791
37368909	37368932	6	+	26472758	KBM7	viability	TGGCTTCCCCAAAGTCACAGAGG	RNF8	ENSG00000112130	-0.1910695636995543	[157,95]	[36,63]	-2	hSpCas9	negative selection	329792
37360520	37360543	6	-	26472758	Raji	viability	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	0.7663466175385323	[37]	[14]	7	hSpCas9	negative selection	520901
37368998	37369021	6	-	26472758	Raji	viability	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	0.5777977916888168	[689]	[238]	5	hSpCas9	negative selection	520902
37368873	37368896	6	+	26472758	Raji	viability	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	0.33565252304671683	[279]	[81]	3	hSpCas9	negative selection	520903
37371535	37371558	6	+	26472758	Raji	viability	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	0.25405318451560865	[270]	[74]	2	hSpCas9	negative selection	520904
37376934	37376957	6	+	26472758	Raji	viability	GGAGAAGATGCAAGCACAGAAGG	RNF8	ENSG00000112130	-0.7857012607098888	[51]	[6]	-6	hSpCas9	negative selection	520905
37354186	37354209	6	+	26472758	Raji	viability	GTCACAGGAGACCGCGCCGGTGG	RNF8	ENSG00000112130	0.30768218585943075	[93]	[26]	3	hSpCas9	negative selection	520906
37368574	37368597	6	-	26472758	Raji	viability	GCATTCTCCTTATTTTCCAGAGG	RNF8	ENSG00000112130	-0.16391848644379503	[139]	[28]	-1	hSpCas9	negative selection	520907
37368889	37368912	6	+	26472758	Raji	viability	ACAGGGGCTCCCATTTACCCTGG	RNF8	ENSG00000112130	-0.023320156270994374	[126]	[28]	0	hSpCas9	negative selection	520908
37371517	37371540	6	+	26472758	Raji	viability	GGAGATAGCCCAAGGAGAAAAGG	RNF8	ENSG00000112130	-1.150768649080448	[353]	[36]	-7	hSpCas9	negative selection	520909
37368909	37368932	6	+	26472758	Raji	viability	TGGCTTCCCCAAAGTCACAGAGG	RNF8	ENSG00000112130	-0.6230094048691204	[72]	[10]	-5	hSpCas9	negative selection	520910
37360520	37360543	6	-	26472758	K562	viability	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	-5.536940985858212	[54]	[0]	-9	hSpCas9	negative selection	712019
37368998	37369021	6	-	26472758	K562	viability	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-0.9989102688197884	[1017]	[429]	-5	hSpCas9	negative selection	712020
37368873	37368896	6	+	26472758	K562	viability	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-1.0537607644483065	[481]	[195]	-5	hSpCas9	negative selection	712021
37371535	37371558	6	+	26472758	K562	viability	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	-0.500095320820926	[510]	[304]	-3	hSpCas9	negative selection	712022
37376934	37376957	6	+	26472758	K562	viability	GGAGAAGATGCAAGCACAGAAGG	RNF8	ENSG00000112130	1.0069194139397906	[55]	[94]	8	hSpCas9	negative selection	712023
37354186	37354209	6	+	26472758	K562	viability	GTCACAGGAGACCGCGCCGGTGG	RNF8	ENSG00000112130	-1.6941807276694094	[91]	[23]	-7	hSpCas9	negative selection	712024
37368574	37368597	6	-	26472758	K562	viability	GCATTCTCCTTATTTTCCAGAGG	RNF8	ENSG00000112130	0.8041806742624603	[153]	[226]	6	hSpCas9	negative selection	712025
37368889	37368912	6	+	26472758	K562	viability	ACAGGGGCTCCCATTTACCCTGG	RNF8	ENSG00000112130	-0.8594170833180932	[143]	[66]	-5	hSpCas9	negative selection	712026
37371517	37371540	6	+	26472758	K562	viability	GGAGATAGCCCAAGGAGAAAAGG	RNF8	ENSG00000112130	-0.9641015190884435	[482]	[208]	-5	hSpCas9	negative selection	712027
37368909	37368932	6	+	26472758	K562	viability	TGGCTTCCCCAAAGTCACAGAGG	RNF8	ENSG00000112130	-2.17704504077183	[149]	[27]	-7	hSpCas9	negative selection	712028
37354183	37354206	6	+	26627737	DLD1	viability	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	-1.5722167863862058	[1103]	[51,94,188]	-8	hSpCas9	negative selection	832710
37359190	37359213	6	+	26627737	DLD1	viability	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	0.11959583259237207	[434]	[197,159,93]	1	hSpCas9	negative selection	832711
37360499	37360522	6	-	26627737	DLD1	viability	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-2.340713992544258	[65]	[0,10,0]	-9	hSpCas9	negative selection	832712
37368873	37368896	6	+	26627737	DLD1	viability	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-1.2157441145513443	[690]	[69,168,49]	-8	hSpCas9	negative selection	832713
37368998	37369021	6	-	26627737	DLD1	viability	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-1.1354529803787812	[283]	[45,57,20]	-7	hSpCas9	negative selection	832714
37371535	37371558	6	+	26627737	DLD1	viability	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	-0.5945488698854557	[205]	[7,34,78]	-5	hSpCas9	negative selection	832715
37354183	37354206	6	+	26627737	GBM cells	viability after 5 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	0.1471005163121661	[292]	[150,196]	2	hSpCas9	negative selection	915025
37359190	37359213	6	+	26627737	GBM cells	viability after 5 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	0.32737188992685096	[213]	[133,153]	5	hSpCas9	negative selection	915026
37360499	37360522	6	-	26627737	GBM cells	viability after 5 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-1.8115795079193298	[71]	[10,10]	-9	hSpCas9	negative selection	915027
37368873	37368896	6	+	26627737	GBM cells	viability after 5 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-0.2867062173815923	[438]	[223,161]	-4	hSpCas9	negative selection	915028
37368998	37369021	6	-	26627737	GBM cells	viability after 5 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	0.7046946614451792	[130]	[132,95]	8	hSpCas9	negative selection	915029
37371535	37371558	6	+	26627737	GBM cells	viability after 5 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	0.04866099439036775	[127]	[80,60]	0	hSpCas9	negative selection	915030
37354183	37354206	6	+	26627737	GBM cells	viability after 13 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	0.009870943590669451	[292]	[153,164]	0	hSpCas9	negative selection	997340
37359190	37359213	6	+	26627737	GBM cells	viability after 13 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	0.2690854234809874	[213]	[188,99]	3	hSpCas9	negative selection	997341
37360499	37360522	6	-	26627737	GBM cells	viability after 13 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-2.022137893616122	[71]	[2,14]	-9	hSpCas9	negative selection	997342
37368873	37368896	6	+	26627737	GBM cells	viability after 13 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-0.38166605879954024	[438]	[248,128]	-4	hSpCas9	negative selection	997343
37368998	37369021	6	-	26627737	GBM cells	viability after 13 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	0.5588788066444179	[130]	[139,75]	7	hSpCas9	negative selection	997344
37371535	37371558	6	+	26627737	GBM cells	viability after 13 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	-0.12787636081238463	[127]	[78,50]	-1	hSpCas9	negative selection	997345
37354183	37354206	6	+	26627737	GBM cells	viability after 21 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	-1.6057845134470103	[292]	[56,47]	-8	hSpCas9	negative selection	1079655
37359190	37359213	6	+	26627737	GBM cells	viability after 21 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	0.005839086039550745	[213]	[122,110]	0	hSpCas9	negative selection	1079656
37360499	37360522	6	-	26627737	GBM cells	viability after 21 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-1.251138461057261	[71]	[17,14]	-8	hSpCas9	negative selection	1079657
37368873	37368896	6	+	26627737	GBM cells	viability after 21 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-0.7012280435166741	[438]	[153,139]	-6	hSpCas9	negative selection	1079658
37368998	37369021	6	-	26627737	GBM cells	viability after 21 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-0.32142503495988906	[130]	[57,55]	-3	hSpCas9	negative selection	1079659
37371535	37371558	6	+	26627737	GBM cells	viability after 21 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	-0.7854685819138089	[127]	[43,36]	-6	hSpCas9	negative selection	1079660
37354183	37354206	6	+	26627737	RPE1	viability after 9 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	-1.6749268217938509	[983]	[116,69]	-8	hSpCas9	negative selection	1161970
37359190	37359213	6	+	26627737	RPE1	viability after 9 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	-0.0885125523555823	[811]	[218,264]	0	hSpCas9	negative selection	1161971
37360499	37360522	6	-	26627737	RPE1	viability after 9 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-5.6283342178622835	[157]	[0,0]	-9	hSpCas9	negative selection	1161972
37368873	37368896	6	+	26627737	RPE1	viability after 9 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-1.9908393899012786	[1704]	[125,144]	-8	hSpCas9	negative selection	1161973
37368998	37369021	6	-	26627737	RPE1	viability after 9 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-4.01612200931689	[732]	[11,16]	-9	hSpCas9	negative selection	1161974
37371535	37371558	6	+	26627737	RPE1	viability after 9 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	-2.8155984157951295	[552]	[38,5]	-9	hSpCas9	negative selection	1161975
37354183	37354206	6	+	26627737	RPE1	viability after 12 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	-1.820885766260472	[983]	[68,80]	-8	hSpCas9	negative selection	1244285
37359190	37359213	6	+	26627737	RPE1	viability after 12 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	-0.20916467632281505	[811]	[195,180]	-1	hSpCas9	negative selection	1244286
37360499	37360522	6	-	26627737	RPE1	viability after 12 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-5.407669336503965	[157]	[0,0]	-9	hSpCas9	negative selection	1244287
37368873	37368896	6	+	26627737	RPE1	viability after 12 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-2.110358029328623	[1704]	[91,120]	-8	hSpCas9	negative selection	1244288
37368998	37369021	6	-	26627737	RPE1	viability after 12 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-2.2791657790135957	[732]	[42,37]	-8	hSpCas9	negative selection	1244289
37371535	37371558	6	+	26627737	RPE1	viability after 12 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	-1.2978653274992238	[552]	[91,26]	-7	hSpCas9	negative selection	1244290
37354183	37354206	6	+	26627737	RPE1	viability after 15 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	-2.3713284381696367	[983]	[8,96]	-8	hSpCas9	negative selection	1326600
37359190	37359213	6	+	26627737	RPE1	viability after 15 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	0.011563300809135826	[811]	[228,233]	0	hSpCas9	negative selection	1326601
37360499	37360522	6	-	26627737	RPE1	viability after 15 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-5.482031874305209	[157]	[0,0]	-9	hSpCas9	negative selection	1326602
37368873	37368896	6	+	26627737	RPE1	viability after 15 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-2.265030695957848	[1704]	[52,145]	-8	hSpCas9	negative selection	1326603
37368998	37369021	6	-	26627737	RPE1	viability after 15 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-2.551608321684964	[732]	[70,0]	-8	hSpCas9	negative selection	1326604
37371535	37371558	6	+	26627737	RPE1	viability after 15 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	-1.3772290018378814	[552]	[75,44]	-7	hSpCas9	negative selection	1326605
37354183	37354206	6	+	26627737	RPE1	viability after 18 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	-2.443028555831065	[983]	[43,53]	-8	hSpCas9	negative selection	1408915
37359190	37359213	6	+	26627737	RPE1	viability after 18 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	-0.3534234946160224	[811]	[142,201]	-2	hSpCas9	negative selection	1408916
37360499	37360522	6	-	26627737	RPE1	viability after 18 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-5.41411248807636	[157]	[0,0]	-9	hSpCas9	negative selection	1408917
37368873	37368896	6	+	26627737	RPE1	viability after 18 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-1.5548862363664084	[1704]	[115,199]	-7	hSpCas9	negative selection	1408918
37368998	37369021	6	-	26627737	RPE1	viability after 18 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-2.591710307373616	[732]	[41,22]	-8	hSpCas9	negative selection	1408919
37371535	37371558	6	+	26627737	RPE1	viability after 18 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	-0.8600017113365048	[552]	[146,12]	-5	hSpCas9	negative selection	1408920
37354183	37354206	6	+	26627737	HeLa	viability after 8 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	-1.1148691361776435	[755]	[109,162,171]	-8	hSpCas9	negative selection	1491230
37359190	37359213	6	+	26627737	HeLa	viability after 8 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	0.36026266595322554	[367]	[244,154,223]	3	hSpCas9	negative selection	1491231
37360499	37360522	6	-	26627737	HeLa	viability after 8 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-0.26631735891202535	[91]	[16,41,36]	-3	hSpCas9	negative selection	1491232
37368873	37368896	6	+	26627737	HeLa	viability after 8 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-1.0141263299562064	[728]	[303,93,108]	-8	hSpCas9	negative selection	1491233
37368998	37369021	6	-	26627737	HeLa	viability after 8 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-1.4122042527766547	[492]	[69,66,100]	-8	hSpCas9	negative selection	1491234
37371535	37371558	6	+	26627737	HeLa	viability after 8 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	-0.10802878011847472	[201]	[120,15,113]	-1	hSpCas9	negative selection	1491235
37354183	37354206	6	+	26627737	HeLa	viability after 12 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	-1.4903020948006012	[755]	[91,73,170]	-8	hSpCas9	negative selection	1573545
37359190	37359213	6	+	26627737	HeLa	viability after 12 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	-0.08009443600594338	[367]	[202,61,176]	0	hSpCas9	negative selection	1573546
37360499	37360522	6	-	26627737	HeLa	viability after 12 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-2.925018411220611	[91]	[7,5,0]	-9	hSpCas9	negative selection	1573547
37368873	37368896	6	+	26627737	HeLa	viability after 12 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-1.2852221314083936	[728]	[96,161,106]	-8	hSpCas9	negative selection	1573548
37368998	37369021	6	-	26627737	HeLa	viability after 12 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-0.5877045283221224	[492]	[331,63,23]	-5	hSpCas9	negative selection	1573549
37371535	37371558	6	+	26627737	HeLa	viability after 12 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	-0.02133106023678355	[201]	[65,84,94]	0	hSpCas9	negative selection	1573550
37354183	37354206	6	+	26627737	HeLa	viability after 15 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	-1.1506467473758724	[755]	[214,59,139]	-7	hSpCas9	negative selection	1655860
37359190	37359213	6	+	26627737	HeLa	viability after 15 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	0.747982241442004	[367]	[387,101,263]	6	hSpCas9	negative selection	1655861
37360499	37360522	6	-	26627737	HeLa	viability after 15 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-3.1898254796770082	[91]	[9,0,0]	-9	hSpCas9	negative selection	1655862
37368873	37368896	6	+	26627737	HeLa	viability after 15 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-0.5247690971557735	[728]	[131,254,234]	-4	hSpCas9	negative selection	1655863
37368998	37369021	6	-	26627737	HeLa	viability after 15 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-1.9348916337324495	[492]	[38,73,43]	-9	hSpCas9	negative selection	1655864
37371535	37371558	6	+	26627737	HeLa	viability after 15 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	0.17038374195430184	[201]	[93,25,162]	1	hSpCas9	negative selection	1655865
37354183	37354206	6	+	26627737	HeLa	viability after 18 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	-1.1347020413643911	[755]	[150,44,139]	-7	hSpCas9	negative selection	1738175
37359190	37359213	6	+	26627737	HeLa	viability after 18 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	0.7459103041314232	[367]	[259,83,263]	6	hSpCas9	negative selection	1738176
37360499	37360522	6	-	26627737	HeLa	viability after 18 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-2.952447101825862	[91]	[7,0,0]	-9	hSpCas9	negative selection	1738177
37368873	37368896	6	+	26627737	HeLa	viability after 18 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-0.47836808935296005	[728]	[100,211,234]	-4	hSpCas9	negative selection	1738178
37368998	37369021	6	-	26627737	HeLa	viability after 18 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-1.82327445464612	[492]	[28,67,43]	-9	hSpCas9	negative selection	1738179
37371535	37371558	6	+	26627737	HeLa	viability after 18 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	0.24766827388056178	[201]	[70,23,162]	2	hSpCas9	negative selection	1738180
37354183	37354206	6	+	26627737	HCT116	viability after 6 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	1.1370513482664408	[528]	[111,221]	6	hSpCas9	negative selection	1820490
37359190	37359213	6	+	26627737	HCT116	viability after 6 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	-0.4442611076831813	[268]	[81,2]	-3	hSpCas9	negative selection	1820491
37360499	37360522	6	-	26627737	HCT116	viability after 6 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-0.6281341499014241	[222]	[61,0]	-4	hSpCas9	negative selection	1820492
37368873	37368896	6	+	26627737	HCT116	viability after 6 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-0.6716276477108917	[831]	[201,15]	-4	hSpCas9	negative selection	1820493
37368998	37369021	6	-	26627737	HCT116	viability after 6 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-0.24145631676444584	[475]	[3,95]	-1	hSpCas9	negative selection	1820494
37371535	37371558	6	+	26627737	HCT116	viability after 6 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	0.5666528009684693	[310]	[132,38]	3	hSpCas9	negative selection	1820495
37354183	37354206	6	+	26627737	HCT116	viability after 8 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	-0.6357844816702247	[589]	[260,188,178]	-6	hSpCas9	negative selection	1902805
37359190	37359213	6	+	26627737	HCT116	viability after 8 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	0.04305469453995636	[284]	[108,175,198]	0	hSpCas9	negative selection	1902806
37360499	37360522	6	-	26627737	HCT116	viability after 8 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	1.247123335210233	[11]	[8,24,12]	8	hSpCas9	negative selection	1902807
37368873	37368896	6	+	26627737	HCT116	viability after 8 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-0.03578666604683789	[458]	[229,190,317]	0	hSpCas9	negative selection	1902808
37368998	37369021	6	-	26627737	HCT116	viability after 8 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	0.6444945718163865	[110]	[40,160,83]	6	hSpCas9	negative selection	1902809
37371535	37371558	6	+	26627737	HCT116	viability after 8 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	1.4137162056279573	[59]	[73,101,87]	9	hSpCas9	negative selection	1902810
37354183	37354206	6	+	26627737	HCT116	viability after 9 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	0.06881142061210163	[528]	[98,186]	0	hSpCas9	negative selection	1985120
37359190	37359213	6	+	26627737	HCT116	viability after 9 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	2.7355086533716477	[268]	[326,597]	9	hSpCas9	negative selection	1985121
37360499	37360522	6	-	26627737	HCT116	viability after 9 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-5.368397860029579	[222]	[1,0]	-9	hSpCas9	negative selection	1985122
37368873	37368896	6	+	26627737	HCT116	viability after 9 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	0.3596873977170912	[831]	[355,228]	2	hSpCas9	negative selection	1985123
37368998	37369021	6	-	26627737	HCT116	viability after 9 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-2.0139928909097162	[475]	[26,34]	-8	hSpCas9	negative selection	1985124
37371535	37371558	6	+	26627737	HCT116	viability after 9 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	-0.7802966523541758	[310]	[44,50]	-5	hSpCas9	negative selection	1985125
37354183	37354206	6	+	26627737	HCT116	viability after 12 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	-1.7989638530670473	[589]	[115,90,57]	-9	hSpCas9	negative selection	2067435
37359190	37359213	6	+	26627737	HCT116	viability after 12 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	0.22125609452908618	[284]	[135,207,183]	2	hSpCas9	negative selection	2067436
37360499	37360522	6	-	26627737	HCT116	viability after 12 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	0.9370740653806271	[11]	[0,3,31]	7	hSpCas9	negative selection	2067437
37368873	37368896	6	+	26627737	HCT116	viability after 12 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-0.2778968286665849	[458]	[189,130,274]	-3	hSpCas9	negative selection	2067438
37368998	37369021	6	-	26627737	HCT116	viability after 12 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	0.24939368855523059	[110]	[59,116,32]	2	hSpCas9	negative selection	2067439
37371535	37371558	6	+	26627737	HCT116	viability after 12 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	1.1397178481158072	[59]	[49,104,55]	8	hSpCas9	negative selection	2067440
37354183	37354206	6	+	26627737	HCT116	viability after 15 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	-1.0103459285458836	[589]	[210,144,153]	-7	hSpCas9	negative selection	2149750
37359190	37359213	6	+	26627737	HCT116	viability after 15 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	-0.02349798361471167	[284]	[115,149,210]	0	hSpCas9	negative selection	2149751
37360499	37360522	6	-	26627737	HCT116	viability after 15 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	0.17292441018051985	[11]	[20,2,0]	1	hSpCas9	negative selection	2149752
37368873	37368896	6	+	26627737	HCT116	viability after 15 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-0.4163958299874253	[458]	[198,135,256]	-4	hSpCas9	negative selection	2149753
37368998	37369021	6	-	26627737	HCT116	viability after 15 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	0.4473760468375009	[110]	[114,129,19]	4	hSpCas9	negative selection	2149754
37371535	37371558	6	+	26627737	HCT116	viability after 15 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	0.4907809062924573	[59]	[27,84,29]	4	hSpCas9	negative selection	2149755
37354183	37354206	6	+	26627737	HCT116	viability after 18 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	-1.0216196194305656	[589]	[214,96,110]	-7	hSpCas9	negative selection	2232065
37359190	37359213	6	+	26627737	HCT116	viability after 18 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	0.4750891409115351	[284]	[207,180,185]	4	hSpCas9	negative selection	2232066
37360499	37360522	6	-	26627737	HCT116	viability after 18 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	0.4274852792714334	[11]	[11,0,10]	3	hSpCas9	negative selection	2232067
37368873	37368896	6	+	26627737	HCT116	viability after 18 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-0.9961602574479897	[458]	[53,123,156]	-7	hSpCas9	negative selection	2232068
37368998	37369021	6	-	26627737	HCT116	viability after 18 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-0.10417224914228917	[110]	[27,56,64]	-1	hSpCas9	negative selection	2232069
37371535	37371558	6	+	26627737	HCT116	viability after 18 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	0.8711462273346466	[59]	[29,63,64]	7	hSpCas9	negative selection	2232070
37354171	37354194	6	+	24336569	HL60	viability	GAGCCCGGCTTCTTCGTCACAGG	RNF8	ENSG00000112130	0.32648397386362826	[152]	[405]	3	hSpCas9	negative selection	2290075
37354183	37354206	6	+	24336569	HL60	viability	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	-1.182060543951191	[1068]	[996]	-8	hSpCas9	negative selection	2290076
37354190	37354213	6	+	24336569	HL60	viability	CAGGAGACCGCGCCGGTGGCCGG	RNF8	ENSG00000112130	0.8288749737553047	[194]	[732]	6	hSpCas9	negative selection	2290077
37354202	37354225	6	-	24336569	HL60	viability	CAGGCACCAGCTCCGGCCACCGG	RNF8	ENSG00000112130	-0.3925625601016382	[646]	[1042]	-3	hSpCas9	negative selection	2290078
37354208	37354231	6	+	24336569	HL60	viability	GCCGGAGCTGGTGCCTGCGGCGG	RNF8	ENSG00000112130	-1.5053953887839697	[1138]	[848]	-8	hSpCas9	negative selection	2290079
37354213	37354236	6	+	24336569	HL60	viability	AGCTGGTGCCTGCGGCGGGTGGG	RNF8	ENSG00000112130	-0.6766223684559409	[70]	[93]	-6	hSpCas9	negative selection	2290080
37354239	37354262	6	+	24336569	HL60	viability	GAGCGCCGGGTGGCTGCTGCTGG	RNF8	ENSG00000112130	-0.45291233136005726	[488]	[755]	-4	hSpCas9	negative selection	2290081
37354244	37354267	6	-	24336569	HL60	viability	ATCTTCCAGCAGCAGCCACCCGG	RNF8	ENSG00000112130	-2.0518831100791783	[530]	[270]	-9	hSpCas9	negative selection	2290082
37354254	37354277	6	+	24336569	HL60	viability	GCTGCTGGAAGATGGGTGCGAGG	RNF8	ENSG00000112130	-0.9777982112410905	[1650]	[1773]	-7	hSpCas9	negative selection	2290083
37360434	37360457	6	+	24336569	HL60	viability	GTTGTCTCCCAGGTGACTGTAGG	RNF8	ENSG00000112130	-2.1749654884600638	[1226]	[574]	-9	hSpCas9	negative selection	2290084
37354171	37354194	6	+	24336569	KBM7	viability	GAGCCCGGCTTCTTCGTCACAGG	RNF8	ENSG00000112130	-0.2861157738547664	[265]	[594]	-2	hSpCas9	negative selection	2357252
37354183	37354206	6	+	24336569	KBM7	viability	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	-1.1698607449579757	[390]	[473]	-7	hSpCas9	negative selection	2357253
37354190	37354213	6	+	24336569	KBM7	viability	CAGGAGACCGCGCCGGTGGCCGG	RNF8	ENSG00000112130	-0.4194555956344946	[380]	[776]	-3	hSpCas9	negative selection	2357254
37354202	37354225	6	-	24336569	KBM7	viability	CAGGCACCAGCTCCGGCCACCGG	RNF8	ENSG00000112130	-1.6247942339216725	[371]	[328]	-8	hSpCas9	negative selection	2357255
37354208	37354231	6	+	24336569	KBM7	viability	GCCGGAGCTGGTGCCTGCGGCGG	RNF8	ENSG00000112130	-2.7343714290468313	[648]	[265]	-9	hSpCas9	negative selection	2357256
37354213	37354236	6	+	24336569	KBM7	viability	AGCTGGTGCCTGCGGCGGGTGGG	RNF8	ENSG00000112130	-1.8827945777653565	[95]	[70]	-8	hSpCas9	negative selection	2357257
37354239	37354262	6	+	24336569	KBM7	viability	GAGCGCCGGGTGGCTGCTGCTGG	RNF8	ENSG00000112130	-3.8761401399274718	[392]	[72]	-9	hSpCas9	negative selection	2357258
37354244	37354267	6	-	24336569	KBM7	viability	ATCTTCCAGCAGCAGCCACCCGG	RNF8	ENSG00000112130	-0.846898462080796	[212]	[322]	-6	hSpCas9	negative selection	2357259
37354254	37354277	6	+	24336569	KBM7	viability	GCTGCTGGAAGATGGGTGCGAGG	RNF8	ENSG00000112130	-1.4837718481722637	[887]	[865]	-7	hSpCas9	negative selection	2357260
37360434	37360457	6	+	24336569	KBM7	viability	GTTGTCTCCCAGGTGACTGTAGG	RNF8	ENSG00000112130	-1.1982789017489177	[386]	[459]	-7	hSpCas9	negative selection	2357261
37376686	37376709	6	+	25494202	A375	resistance to PLX-4720 (puromycin)	ACAAACATTCAGACCATAGCAAG	RNF8	ENSG00000112130	-1.10752078513605	[62,211]	[17,9]	-6	dCas9-VP64	positive selection	2404688
37376686	37376709	6	+	25494202	A375	resistance to PLX-4720 (zeocin)	ACAAACATTCAGACCATAGCAAG	RNF8	ENSG00000112130	-0.3258106290302841	[162,79]	[39,23]	-3	dCas9-VP64	positive selection	2499943
37360520	37360543	6	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	-0.22576185182296973	[2,3]	[2,0]	-3	hSpCas9	positive selection	3017398
37360499	37360522	6	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-0.18964378667726653	[4,4]	[4,2]	-3	hSpCas9	positive selection	3017399
37368795	37368818	6	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTCAGCCAGTGAAATCACAGGGG	RNF8	ENSG00000112130	0.17166835572140995	[4,3]	[4,3]	3	hSpCas9	positive selection	3017400
37368838	37368861	6	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TTAGGATCCAAATTGTCAGAGGG	RNF8	ENSG00000112130	-0.4226660936465911	[3,4]	[3,1]	-6	hSpCas9	positive selection	3017401
37360520	37360543	6	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	0.08668475692285288	[2,2]	[3,0]	1	hSpCas9	positive selection	3085256
37360499	37360522	6	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-0.7339265227848	[4,4]	[3,0]	-8	hSpCas9	positive selection	3085257
37368795	37368818	6	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTCAGCCAGTGAAATCACAGGGG	RNF8	ENSG00000112130	-0.6597154872468949	[4,4]	[2,0]	-8	hSpCas9	positive selection	3085258
37368838	37368861	6	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TTAGGATCCAAATTGTCAGAGGG	RNF8	ENSG00000112130	0.4004262132075288	[3,3]	[2,4]	7	hSpCas9	positive selection	3085259
37371559	37371582		-	24336571	A375	resistance to PLX after 7 days	AAGTTACCTCCTGCAGAGCCTGG	RNF8	ENSG00000112130	0.19626271411931495	[22,20]	[24,24]	6	hSpCas9	positive selection	3141454
37371509	37371532		+	24336571	A375	resistance to PLX after 7 days	CAGGGTTTGGAGATAGCCCAAGG	RNF8	ENSG00000112130	-0.09776345079001406	[12,10]	[11,10]	-3	hSpCas9	positive selection	3141456
37360550	37360573		-	24336571	A375	resistance to PLX after 7 days	TGTTGTCCATAATTGTCCATTGG	RNF8	ENSG00000112130	-0.16568571821259903	[56,51]	[48,47]	-5	hSpCas9	positive selection	3141457
37371559	37371582		-	24336571	A375	resistance to PLX after 14 days	AAGTTACCTCCTGCAGAGCCTGG	RNF8	ENSG00000112130	-0.6198640975471935	[24,23]	[6,6]	-7	hSpCas9	positive selection	3199247
37371509	37371532		+	24336571	A375	resistance to PLX after 14 days	CAGGGTTTGGAGATAGCCCAAGG	RNF8	ENSG00000112130	-0.263241931111856	[14,7]	[4,3]	-3	hSpCas9	positive selection	3199249
37360550	37360573		-	24336571	A375	resistance to PLX after 14 days	TGTTGTCCATAATTGTCCATTGG	RNF8	ENSG00000112130	-0.7208066176789543	[56,43]	[11,15]	-8	hSpCas9	positive selection	3199250
37371559	37371582		-	24336571	A375	viability after 7 days	AAGTTACCTCCTGCAGAGCCTGG	RNF8	ENSG00000112130	-0.0013152570826588939	[22]	[22,20]	0	hSpCas9	negative selection	3257040
37371509	37371532		+	24336571	A375	viability after 7 days	CAGGGTTTGGAGATAGCCCAAGG	RNF8	ENSG00000112130	-0.47412944830266796	[17]	[12,10]	-6	hSpCas9	negative selection	3257042
37360550	37360573		-	24336571	A375	viability after 7 days	TGTTGTCCATAATTGTCCATTGG	RNF8	ENSG00000112130	0.5471684623770823	[38]	[56,51]	8	hSpCas9	negative selection	3257043
37371559	37371582		-	24336571	A375	viability after 14 days	AAGTTACCTCCTGCAGAGCCTGG	RNF8	ENSG00000112130	0.1721185594832928	[22]	[24,23]	2	hSpCas9	negative selection	3314833
37371509	37371532		+	24336571	A375	viability after 14 days	CAGGGTTTGGAGATAGCCCAAGG	RNF8	ENSG00000112130	-0.5576948049332535	[17]	[14,7]	-6	hSpCas9	negative selection	3314835
37360550	37360573		-	24336571	A375	viability after 14 days	TGTTGTCCATAATTGTCCATTGG	RNF8	ENSG00000112130	0.45072339209216916	[38]	[56,43]	6	hSpCas9	negative selection	3314836
37360463	37360486	6	+	27383988	293T	resistance to West Nile virus (flavivirus)	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	3.935398116558473	[9,9]	[0,0]	9	hSpCas9	positive selection	3390259
37374613	37374636	6	+	27383988	293T	resistance to West Nile virus (flavivirus)	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	0.48914188666890873	[108,108]	[0,0]	2	hSpCas9	positive selection	3390260
37374637	37374660	6	+	27383988	293T	resistance to West Nile virus (flavivirus)	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	1.5849008694743394	[50,50]	[0,0]	6	hSpCas9	positive selection	3390261
37360520	37360543	6	-	26780180	HT29	viability (Avana library 4 designs)	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	2.33487330179188	[]	[]	8	hSpCas9	negative selection	3455779
37360499	37360522	6	-	26780180	HT29	viability (Avana library 4 designs)	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	2.1999203902533	[]	[]	7	hSpCas9	negative selection	3455780
37368794	37368817	6	+	26780180	HT29	viability (Avana library 4 designs)	GTCAGCCAGTGAAATCACAGGGG	RNF8	ENSG00000112130	1.28032688181686	[]	[]	5	hSpCas9	negative selection	3455781
37368838	37368861	6	-	26780180	HT29	viability (Avana library 4 designs)	TTAGGATCCAAATTGTCAGAGGG	RNF8	ENSG00000112130	2.10021111227499	[]	[]	7	hSpCas9	negative selection	3455782
37360520	37360543	6	-	26780180	A375	viability (Avana lentiCRISPRv2)	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	-18.4291622078957	[]	[]	-9	hSpCas9	negative selection	3553929
37368838	37368861	6	-	26780180	A375	viability (Avana lentiCRISPRv2)	TTAGGATCCAAATTGTCAGAGGG	RNF8	ENSG00000112130	-13.3124990465673	[]	[]	-8	hSpCas9	negative selection	3553930
37360499	37360522	6	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-16.8428581781813	[]	[]	-9	hSpCas9	negative selection	3553931
37368794	37368817	6	+	26780180	A375	viability (Avana lentiCRISPRv2)	GTCAGCCAGTGAAATCACAGGGG	RNF8	ENSG00000112130	-4.7002567180947	[]	[]	-5	hSpCas9	negative selection	3553932
37368793	37368816	6	+	26780180	A375	viability (Avana lentiCRISPRv2)	GGTCAGCCAGTGAAATCACAGGG	RNF8	ENSG00000112130	-4.32042490916248	[]	[]	-5	hSpCas9	negative selection	3553933
37368873	37368896	6	+	26780180	A375	viability (Avana lentiCRISPRv2)	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-4.26541479801902	[]	[]	-5	hSpCas9	negative selection	3553934
37360520	37360543	6	-	26780180	A375	viability (Avana lentiGuide)	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	18.8942824903422	[]	[]	8	hSpCas9	negative selection	3662588
37368838	37368861	6	-	26780180	A375	viability (Avana lentiGuide)	TTAGGATCCAAATTGTCAGAGGG	RNF8	ENSG00000112130	10.1019028991579	[]	[]	7	hSpCas9	negative selection	3662589
37360499	37360522	6	-	26780180	A375	viability (Avana lentiGuide)	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	18.3114593385505	[]	[]	8	hSpCas9	negative selection	3662590
37368794	37368817	6	+	26780180	A375	viability (Avana lentiGuide)	GTCAGCCAGTGAAATCACAGGGG	RNF8	ENSG00000112130	3.68752092084754	[]	[]	3	hSpCas9	negative selection	3662591
37368793	37368816	6	+	26780180	A375	viability (Avana lentiGuide)	GGTCAGCCAGTGAAATCACAGGG	RNF8	ENSG00000112130	3.69140763849488	[]	[]	3	hSpCas9	negative selection	3662592
37368873	37368896	6	+	26780180	A375	viability (Avana lentiGuide)	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	0.569839321892876	[]	[]	0	hSpCas9	negative selection	3662593
37360520	37360543	6	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	-1.5775470687399713	[5]	[1,0]	-9	hSpCas9	positive selection	3771195
37368838	37368861	6	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTAGGATCCAAATTGTCAGAGGG	RNF8	ENSG00000112130	-0.7804354518906914	[7]	[3,4]	-8	hSpCas9	positive selection	3771196
37360499	37360522	6	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-1.2683533442315056	[5]	[1,1]	-9	hSpCas9	positive selection	3771197
37368794	37368817	6	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTCAGCCAGTGAAATCACAGGGG	RNF8	ENSG00000112130	-0.45104756982920635	[5]	[4,3]	-6	hSpCas9	positive selection	3771198
37368793	37368816	6	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGTCAGCCAGTGAAATCACAGGG	RNF8	ENSG00000112130	-0.16780518802765254	[4]	[4,3]	-3	hSpCas9	positive selection	3771199
37368873	37368896	6	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-0.29389629624477115	[4]	[3,3]	-4	hSpCas9	positive selection	3771200
37360520	37360543	6	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	-0.9698016306429562	[4]	[0,3]	-8	hSpCas9	positive selection	3879802
37368838	37368861	6	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTAGGATCCAAATTGTCAGAGGG	RNF8	ENSG00000112130	-0.5596306480154485	[5]	[5,0]	-6	hSpCas9	positive selection	3879803
37360499	37360522	6	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-0.3605767042831011	[6]	[5,3]	-5	hSpCas9	positive selection	3879804
37368794	37368817	6	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTCAGCCAGTGAAATCACAGGGG	RNF8	ENSG00000112130	-0.09764352895339658	[6]	[4,4]	-1	hSpCas9	positive selection	3879805
37368793	37368816	6	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGTCAGCCAGTGAAATCACAGGG	RNF8	ENSG00000112130	0.07326001654381778	[5]	[4,4]	1	hSpCas9	positive selection	3879806
37368873	37368896	6	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-0.7253863726587884	[4]	[2,1]	-7	hSpCas9	positive selection	3879807
37374637	37374660	6	+	26780180	A375	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	1.09108601844382	[]	[]	5	hSpCas9	negative selection	3989921
37360463	37360486	6	+	26780180	A375	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	0.482453776674976	[]	[]	1	hSpCas9	negative selection	3989922
37368479	37368502	6	+	26780180	A375	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	0.906504704175048	[]	[]	4	hSpCas9	negative selection	3989923
37368509	37368532	6	+	26780180	A375	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	-0.0128903502732954	[]	[]	0	hSpCas9	negative selection	3989924
37360440	37360463	6	+	26780180	A375	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	1.60190896795412	[]	[]	8	hSpCas9	negative selection	3989925
37374613	37374636	6	+	26780180	A375	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	0.551386861340576	[]	[]	1	hSpCas9	negative selection	3989926
37374637	37374660	6	+	26780180	HT29	viability (GeCKOv2 library)	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	0.521016194627619	[]	[]	1	hSpCas9	negative selection	4097887
37360463	37360486	6	+	26780180	HT29	viability (GeCKOv2 library)	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	0.644801434458927	[]	[]	2	hSpCas9	negative selection	4097888
37368479	37368502	6	+	26780180	HT29	viability (GeCKOv2 library)	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	1.1764373030242	[]	[]	6	hSpCas9	negative selection	4097889
37368509	37368532	6	+	26780180	HT29	viability (GeCKOv2 library)	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.748896173071125	[]	[]	3	hSpCas9	negative selection	4097890
37360440	37360463	6	+	26780180	HT29	viability (GeCKOv2 library)	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	1.90317944613017	[]	[]	9	hSpCas9	negative selection	4097891
37374613	37374636	6	+	26780180	HT29	viability (GeCKOv2 library)	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	0.697528101150908	[]	[]	2	hSpCas9	negative selection	4097892
37371559	37371582	6	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	AAGTTACCTCCTGCAGAGCCTGG	RNF8	ENSG00000112130	-0.01286966945771012	[4]	[3,2]	0	hSpCas9	positive selection	4166992
37371509	37371532	6	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CAGGGTTTGGAGATAGCCCAAGG	RNF8	ENSG00000112130	-0.22767931985629966	[4]	[2,1]	-5	hSpCas9	positive selection	4166994
37360550	37360573	6	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TGTTGTCCATAATTGTCCATTGG	RNF8	ENSG00000112130	0.17013097703753272	[5]	[4,3]	4	hSpCas9	positive selection	4166995
37371559	37371582	6	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	AAGTTACCTCCTGCAGAGCCTGG	RNF8	ENSG00000112130	-0.1146196744536936	[4]	[2,1,2,0]	-2	hSpCas9	positive selection	4231014
37371509	37371532	6	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CAGGGTTTGGAGATAGCCCAAGG	RNF8	ENSG00000112130	-0.17107244859208087	[2]	[0,2,0,0]	-2	hSpCas9	positive selection	4231016
37360550	37360573	6	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TGTTGTCCATAATTGTCCATTGG	RNF8	ENSG00000112130	0.7528415326981632	[5]	[2,3,4,4]	5	hSpCas9	positive selection	4231017
37368509	37368532	6	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.37266755612630453	[2]	[3,2]	7	hSpCas9	positive selection	4295331
37368479	37368502	6	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	-0.05484220482128849	[2]	[2,0]	-1	hSpCas9	positive selection	4295332
37360440	37360463	6	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	0.08839880610812803	[2]	[1,1]	1	hSpCas9	positive selection	4295333
37360463	37360486	6	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-0.40063720301709327	[0]	[0,0]	-7	hSpCas9	positive selection	4359585
37374613	37374636	6	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	0.18940251887754744	[2]	[2,1]	4	hSpCas9	positive selection	4359586
37374637	37374660	6	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.8860034646213737	[1]	[0,0]	-9	hSpCas9	positive selection	4359587
37354261	37354283	6	+	27760321	OCIAML3	viability	GAAGATGGGTGCGAGGTACGGG	RNF8	ENSG00000112130	-1.2014242410287557	[584,464]	[163,194]	-8	hSpCas9	negative selection	4435368
37360499	37360521	6	-	27760321	OCIAML3	viability	GTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-1.0716498378415873	[433,418]	[125,201]	-7	hSpCas9	negative selection	4435369
37368716	37368738	6	+	27760321	OCIAML3	viability	TGGATGAATTAGCAGGTCCTGG	RNF8	ENSG00000112130	-0.2814350875309204	[430,405]	[295,234]	-3	hSpCas9	negative selection	4435370
37368839	37368861	6	-	27760321	OCIAML3	viability	TTAGGATCCAAATTGTCAGAGG	RNF8	ENSG00000112130	-0.3853282098549299	[255,214]	[159,114]	-4	hSpCas9	negative selection	4435371
37368873	37368895	6	+	27760321	OCIAML3	viability	TGAGCCAAGTAAGACCACAGGG	RNF8	ENSG00000112130	-0.49314884728431374	[202,179]	[87,129]	-5	hSpCas9	negative selection	4435372
37354261	37354283	6	+	27760321	OCIAML2	viability	GAAGATGGGTGCGAGGTACGGG	RNF8	ENSG00000112130	-1.2307402506298581	[584,464]	[178,180]	-8	hSpCas9	negative selection	4518831
37360499	37360521	6	-	27760321	OCIAML2	viability	GTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-1.4208132378639262	[433,418]	[113,148]	-8	hSpCas9	negative selection	4518832
37368716	37368738	6	+	27760321	OCIAML2	viability	TGGATGAATTAGCAGGTCCTGG	RNF8	ENSG00000112130	0.001188885352802746	[430,405]	[301,387]	0	hSpCas9	negative selection	4518833
37368839	37368861	6	-	27760321	OCIAML2	viability	TTAGGATCCAAATTGTCAGAGG	RNF8	ENSG00000112130	-0.4041370399453367	[255,214]	[145,139]	-5	hSpCas9	negative selection	4518834
37368873	37368895	6	+	27760321	OCIAML2	viability	TGAGCCAAGTAAGACCACAGGG	RNF8	ENSG00000112130	0.26293446702760537	[202,179]	[204,159]	3	hSpCas9	negative selection	4518835
37354261	37354283	6	+	27760321	MV411	viability	GAAGATGGGTGCGAGGTACGGG	RNF8	ENSG00000112130	0.08933512992205112	[584,464]	[283,489]	0	hSpCas9	negative selection	4602294
37360499	37360521	6	-	27760321	MV411	viability	GTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-0.004464670040742136	[433,418]	[394,109]	0	hSpCas9	negative selection	4602295
37368716	37368738	6	+	27760321	MV411	viability	TGGATGAATTAGCAGGTCCTGG	RNF8	ENSG00000112130	-1.3937190743950594	[430,405]	[95,118]	-7	hSpCas9	negative selection	4602296
37368839	37368861	6	-	27760321	MV411	viability	TTAGGATCCAAATTGTCAGAGG	RNF8	ENSG00000112130	-0.6537656204943213	[255,214]	[95,101]	-4	hSpCas9	negative selection	4602297
37368873	37368895	6	+	27760321	MV411	viability	TGAGCCAAGTAAGACCACAGGG	RNF8	ENSG00000112130	-0.20817686368566446	[202,179]	[121,89]	-1	hSpCas9	negative selection	4602298
37354261	37354283	6	+	27760321	HL60	viability	GAAGATGGGTGCGAGGTACGGG	RNF8	ENSG00000112130	-0.941288959374282	[584,464]	[187,257]	-7	hSpCas9	negative selection	4685757
37360499	37360521	6	-	27760321	HL60	viability	GTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-0.8340464286756549	[433,418]	[188,202]	-7	hSpCas9	negative selection	4685758
37368716	37368738	6	+	27760321	HL60	viability	TGGATGAATTAGCAGGTCCTGG	RNF8	ENSG00000112130	-0.020062739624131368	[430,405]	[367,304]	0	hSpCas9	negative selection	4685759
37368839	37368861	6	-	27760321	HL60	viability	TTAGGATCCAAATTGTCAGAGG	RNF8	ENSG00000112130	-0.5531541966439778	[255,214]	[133,126]	-5	hSpCas9	negative selection	4685760
37368873	37368895	6	+	27760321	HL60	viability	TGAGCCAAGTAAGACCACAGGG	RNF8	ENSG00000112130	-0.6379179803166171	[202,179]	[128,69]	-6	hSpCas9	negative selection	4685761
37354261	37354283	6	+	27760321	HT1080	viability	GAAGATGGGTGCGAGGTACGGG	RNF8	ENSG00000112130	-1.4942522561560851	[464,362]	[69,45]	-5	hSpCas9	negative selection	4769220
37360499	37360521	6	-	27760321	HT1080	viability	GTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-4.352902923799338	[418,326]	[12,0]	-8	hSpCas9	negative selection	4769221
37368716	37368738	6	+	27760321	HT1080	viability	TGGATGAATTAGCAGGTCCTGG	RNF8	ENSG00000112130	-0.08172226562484412	[405,316]	[179,87]	0	hSpCas9	negative selection	4769222
37368839	37368861	6	-	27760321	HT1080	viability	TTAGGATCCAAATTGTCAGAGG	RNF8	ENSG00000112130	-1.7340866957190948	[214,167]	[10,35]	-6	hSpCas9	negative selection	4769223
37368873	37368895	6	+	27760321	HT1080	viability	TGAGCCAAGTAAGACCACAGGG	RNF8	ENSG00000112130	0.8331117568163491	[179,140]	[101,126]	4	hSpCas9	negative selection	4769224
37354261	37354283	6	+	27760321	HT29	viability after 7 days	GAAGATGGGTGCGAGGTACGGG	RNF8	ENSG00000112130	0.31678573217499195	[464,362]	[761,635,605]	5	hSpCas9	negative selection	4852683
37360499	37360521	6	-	27760321	HT29	viability after 7 days	GTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-0.0621122295908186	[418,326]	[520,303,557]	-1	hSpCas9	negative selection	4852684
37368716	37368738	6	+	27760321	HT29	viability after 7 days	TGGATGAATTAGCAGGTCCTGG	RNF8	ENSG00000112130	0.08242430930420423	[405,316]	[458,489,520]	1	hSpCas9	negative selection	4852685
37368839	37368861	6	-	27760321	HT29	viability after 7 days	TTAGGATCCAAATTGTCAGAGG	RNF8	ENSG00000112130	0.21784110544065938	[214,167]	[310,353,199]	3	hSpCas9	negative selection	4852686
37368873	37368895	6	+	27760321	HT29	viability after 7 days	TGAGCCAAGTAAGACCACAGGG	RNF8	ENSG00000112130	0.7116182060420146	[179,140]	[310,242,451]	9	hSpCas9	negative selection	4852687
37354261	37354283	6	+	27760321	HT29	viability after 25 days	GAAGATGGGTGCGAGGTACGGG	RNF8	ENSG00000112130	-0.09262460272853239	[464,362]	[388,353,607]	-1	hSpCas9	negative selection	4936146
37360499	37360521	6	-	27760321	HT29	viability after 25 days	GTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-0.79859540368234	[418,326]	[326,171,228]	-6	hSpCas9	negative selection	4936147
37368716	37368738	6	+	27760321	HT29	viability after 25 days	TGGATGAATTAGCAGGTCCTGG	RNF8	ENSG00000112130	0.26961318989702454	[405,316]	[584,420,479]	2	hSpCas9	negative selection	4936148
37368839	37368861	6	-	27760321	HT29	viability after 25 days	TTAGGATCCAAATTGTCAGAGG	RNF8	ENSG00000112130	-0.8649517165363066	[214,167]	[136,69,155]	-6	hSpCas9	negative selection	4936149
37368873	37368895	6	+	27760321	HT29	viability after 25 days	TGAGCCAAGTAAGACCACAGGG	RNF8	ENSG00000112130	0.2698986677075309	[179,140]	[156,291,217]	3	hSpCas9	negative selection	4936150
37354261	37354283	6	+	27760321	HT29	viability after 22 days	GAAGATGGGTGCGAGGTACGGG	RNF8	ENSG00000112130	-0.37792346262413345	[464,362]	[431,323,346]	-4	hSpCas9	negative selection	5019609
37360499	37360521	6	-	27760321	HT29	viability after 22 days	GTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-0.7102969985936881	[418,326]	[181,330,279]	-5	hSpCas9	negative selection	5019610
37368716	37368738	6	+	27760321	HT29	viability after 22 days	TGGATGAATTAGCAGGTCCTGG	RNF8	ENSG00000112130	0.09584549778142445	[405,316]	[507,405,423]	0	hSpCas9	negative selection	5019611
37368839	37368861	6	-	27760321	HT29	viability after 22 days	TTAGGATCCAAATTGTCAGAGG	RNF8	ENSG00000112130	-0.08817787979001201	[214,167]	[163,149,312]	-1	hSpCas9	negative selection	5019612
37368873	37368895	6	+	27760321	HT29	viability after 22 days	TGAGCCAAGTAAGACCACAGGG	RNF8	ENSG00000112130	0.7700176394580389	[179,140]	[379,325,240]	8	hSpCas9	negative selection	5019613
37354261	37354283	6	+	27760321	HT29	viability after 19 days	GAAGATGGGTGCGAGGTACGGG	RNF8	ENSG00000112130	-0.16151529848557056	[464,362]	[485,653,146]	-1	hSpCas9	negative selection	5103072
37360499	37360521	6	-	27760321	HT29	viability after 19 days	GTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-0.8033848736770852	[418,326]	[209,72,438]	-6	hSpCas9	negative selection	5103073
37368716	37368738	6	+	27760321	HT29	viability after 19 days	TGGATGAATTAGCAGGTCCTGG	RNF8	ENSG00000112130	0.1260293954194994	[405,316]	[462,667,231]	1	hSpCas9	negative selection	5103074
37368839	37368861	6	-	27760321	HT29	viability after 19 days	TTAGGATCCAAATTGTCAGAGG	RNF8	ENSG00000112130	0.2561546454678262	[214,167]	[336,207,247]	2	hSpCas9	negative selection	5103075
37368873	37368895	6	+	27760321	HT29	viability after 19 days	TGAGCCAAGTAAGACCACAGGG	RNF8	ENSG00000112130	0.5327975234033662	[179,140]	[182,391,214]	5	hSpCas9	negative selection	5103076
37354261	37354283	6	+	27760321	HT29	viability after 16 days	GAAGATGGGTGCGAGGTACGGG	RNF8	ENSG00000112130	0.0977245086156388	[464,362]	[641,292,570]	1	hSpCas9	negative selection	5186535
37360499	37360521	6	-	27760321	HT29	viability after 16 days	GTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-0.801583118597342	[418,326]	[131,203,372]	-6	hSpCas9	negative selection	5186536
37368716	37368738	6	+	27760321	HT29	viability after 16 days	TGGATGAATTAGCAGGTCCTGG	RNF8	ENSG00000112130	-0.16149588411272928	[405,316]	[213,394,460]	-2	hSpCas9	negative selection	5186537
37368839	37368861	6	-	27760321	HT29	viability after 16 days	TTAGGATCCAAATTGTCAGAGG	RNF8	ENSG00000112130	-0.4592797177057687	[214,167]	[240,138,95]	-5	hSpCas9	negative selection	5186538
37368873	37368895	6	+	27760321	HT29	viability after 16 days	TGAGCCAAGTAAGACCACAGGG	RNF8	ENSG00000112130	0.1307903495444438	[179,140]	[147,170,266]	1	hSpCas9	negative selection	5186539
37354261	37354283	6	+	27760321	HT29	viability after 13 days	GAAGATGGGTGCGAGGTACGGG	RNF8	ENSG00000112130	0.18926081556043317	[464,362]	[508,605,528]	2	hSpCas9	negative selection	5269998
37360499	37360521	6	-	27760321	HT29	viability after 13 days	GTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-0.6878641814386534	[418,326]	[306,268,231]	-6	hSpCas9	negative selection	5269999
37368716	37368738	6	+	27760321	HT29	viability after 13 days	TGGATGAATTAGCAGGTCCTGG	RNF8	ENSG00000112130	0.23354397160100637	[405,316]	[484,463,527]	3	hSpCas9	negative selection	5270000
37368839	37368861	6	-	27760321	HT29	viability after 13 days	TTAGGATCCAAATTGTCAGAGG	RNF8	ENSG00000112130	0.6362543602854288	[214,167]	[573,262,206]	8	hSpCas9	negative selection	5270001
37368873	37368895	6	+	27760321	HT29	viability after 13 days	TGAGCCAAGTAAGACCACAGGG	RNF8	ENSG00000112130	0.10181529052436011	[179,140]	[185,186,224]	1	hSpCas9	negative selection	5270002
37354261	37354283	6	+	27760321	HT29	viability after 10 days	GAAGATGGGTGCGAGGTACGGG	RNF8	ENSG00000112130	-0.03745819449606366	[464,362]	[410,486,609]	0	hSpCas9	negative selection	5353461
37360499	37360521	6	-	27760321	HT29	viability after 10 days	GTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-0.2535487141054499	[418,326]	[359,606,214]	-3	hSpCas9	negative selection	5353462
37368716	37368738	6	+	27760321	HT29	viability after 10 days	TGGATGAATTAGCAGGTCCTGG	RNF8	ENSG00000112130	0.150605462195244	[405,316]	[415,578,509]	2	hSpCas9	negative selection	5353463
37368839	37368861	6	-	27760321	HT29	viability after 10 days	TTAGGATCCAAATTGTCAGAGG	RNF8	ENSG00000112130	0.2609877854629986	[214,167]	[248,151,450]	3	hSpCas9	negative selection	5353464
37368873	37368895	6	+	27760321	HT29	viability after 10 days	TGAGCCAAGTAAGACCACAGGG	RNF8	ENSG00000112130	0.2726998911446026	[179,140]	[121,247,353]	3	hSpCas9	negative selection	5353465
37354261	37354283	6	+	27760321	MOLM13	viability	GAAGATGGGTGCGAGGTACGGG	RNF8	ENSG00000112130	0.2521517686962409	[584,464]	[79,580]	1	hSpCas9	negative selection	5436924
37360499	37360521	6	-	27760321	MOLM13	viability	GTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-1.2829974567356532	[433,418]	[77,116]	-6	hSpCas9	negative selection	5436925
37368716	37368738	6	+	27760321	MOLM13	viability	TGGATGAATTAGCAGGTCCTGG	RNF8	ENSG00000112130	0.3267338552678764	[430,405]	[445,168]	2	hSpCas9	negative selection	5436926
37368839	37368861	6	-	27760321	MOLM13	viability	TTAGGATCCAAATTGTCAGAGG	RNF8	ENSG00000112130	-1.2118734136876288	[255,214]	[61,52]	-6	hSpCas9	negative selection	5436927
37368873	37368895	6	+	27760321	MOLM13	viability	TGAGCCAAGTAAGACCACAGGG	RNF8	ENSG00000112130	-2.0685589490043768	[202,179]	[42,10]	-8	hSpCas9	negative selection	5436928
37354103	37354126	6	+	27661255	K562	viability	GGCAGCCAGAACCTAGGTCAGGG	RNF8	ENSG00000112130	-0.12029154366737516	[1584,1461]	[1232,1025]	-4	dCas9-KRAB	negative selection	5508078
37354208	37354231	6	+	27661255	K562	viability	GCCGGAGCTGGTGCCTGCGGCGG	RNF8	ENSG00000112130	-0.0594863312602841	[773,1060]	[721,679]	-2	dCas9-KRAB	negative selection	5508079
37354460	37354483	6	+	27661255	K562	viability	GCGAGCGGCTGAAGGGTCTGCGG	RNF8	ENSG00000112130	-0.15302004244061698	[1081,885]	[770,656]	-5	dCas9-KRAB	negative selection	5508080
37354464	37354487	6	+	27661255	K562	viability	GCGGCTGAAGGGTCTGCGGTGGG	RNF8	ENSG00000112130	0.14789127367574406	[373,413]	[326,365]	5	dCas9-KRAB	negative selection	5508081
37354497	37354520	6	+	27661255	K562	viability	GGGAGAAATAGGGGCCGAGTGGG	RNF8	ENSG00000112130	-0.035301191369004004	[1282,1645]	[1332,968]	-1	dCas9-KRAB	negative selection	5508082
37368509	37368532	6	+	27260156	BXPC3	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.5332531255944839	[406]	[695,558,556,643]	9	hSpCas9	negative selection	5567791
37368479	37368502	6	+	27260156	BXPC3	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	0.38768518816275144	[224]	[328,305,301,286]	8	hSpCas9	negative selection	5567792
37360440	37360463	6	+	27260156	BXPC3	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.1527862975991755	[247]	[177,274,208,277]	-4	hSpCas9	negative selection	5567793
37360463	37360486	6	+	27260156	BXPC3	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-0.6283917945529338	[42]	[36,6,25,48]	-8	hSpCas9	negative selection	5632045
37374613	37374636	6	+	27260156	BXPC3	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.1069368967301797	[373]	[278,375,364,448]	-2	hSpCas9	negative selection	5632046
37374637	37374660	6	+	27260156	BXPC3	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	0.09930713918238898	[130]	[118,237,104,116]	2	hSpCas9	negative selection	5632047
37368509	37368532	6	+	27260156	A673	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.2566165018506882	[406]	[534,556,573,667]	6	hSpCas9	negative selection	5689042
37368479	37368502	6	+	27260156	A673	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	-0.0190789783645271	[224]	[332,231,267,239]	0	hSpCas9	negative selection	5689043
37360440	37360463	6	+	27260156	A673	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.5044595511788023	[247]	[243,202,150,247]	-8	hSpCas9	negative selection	5689044
37360463	37360486	6	+	27260156	A673	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-0.9052127890118178	[42]	[40,27,27,13]	-9	hSpCas9	negative selection	5753296
37374613	37374636	6	+	27260156	A673	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	0.029257713961871934	[373]	[539,325,585,387]	0	hSpCas9	negative selection	5753297
37374637	37374660	6	+	27260156	A673	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.1535403234479955	[130]	[206,150,92,120]	-4	hSpCas9	negative selection	5753298
37368509	37368532	6	+	27260156	A375	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.768316282643538	[406]	[877,893,713,766]	9	hSpCas9	negative selection	5810293
37368479	37368502	6	+	27260156	A375	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	-0.4363562156657279	[224]	[346,174,108,148]	-6	hSpCas9	negative selection	5810294
37360440	37360463	6	+	27260156	A375	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.21920554425797134	[247]	[207,305,192,289]	-3	hSpCas9	negative selection	5810295
37360463	37360486	6	+	27260156	A375	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-1.6514665014963028	[42]	[27,8,9,15]	-9	hSpCas9	negative selection	5874547
37374613	37374636	6	+	27260156	A375	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	0.3062449450217802	[373]	[540,380,615,591]	4	hSpCas9	negative selection	5874548
37374637	37374660	6	+	27260156	A375	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.3124668038801881	[130]	[60,251,139,63]	-4	hSpCas9	negative selection	5874549
37368509	37368532	6	+	27260156	COLO741	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.45047233598264846	[406]	[697,703,725]	8	hSpCas9	negative selection	5931544
37368479	37368502	6	+	27260156	COLO741	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	0.1447936786682057	[224]	[281,435,237]	3	hSpCas9	negative selection	5931545
37360440	37360463	6	+	27260156	COLO741	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.2235512380971546	[247]	[383,252,191]	-5	hSpCas9	negative selection	5931546
37360463	37360486	6	+	27260156	COLO741	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-0.8658228760844184	[42]	[31,20,36]	-9	hSpCas9	negative selection	5995798
37374613	37374636	6	+	27260156	COLO741	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.15995843593952797	[373]	[500,411,378]	-3	hSpCas9	negative selection	5995799
37374637	37374660	6	+	27260156	COLO741	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.18127186554050723	[130]	[177,118,147]	-4	hSpCas9	negative selection	5995800
37368509	37368532	6	+	27260156	CAL120	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.7890308834380789	[406]	[991,517,1127]	9	hSpCas9	negative selection	6052795
37368479	37368502	6	+	27260156	CAL120	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	0.43725402534452307	[224]	[405,343,390]	6	hSpCas9	negative selection	6052796
37360440	37360463	6	+	27260156	CAL120	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.8336295317737187	[247]	[197,198,126]	-8	hSpCas9	negative selection	6052797
37360463	37360486	6	+	27260156	CAL120	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	0.048579565966708316	[42]	[5,64,86]	0	hSpCas9	negative selection	6117049
37374613	37374636	6	+	27260156	CAL120	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	0.4934152183063617	[373]	[937,368,699]	7	hSpCas9	negative selection	6117050
37374637	37374660	6	+	27260156	CAL120	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.4313075565457194	[130]	[153,114,98]	-6	hSpCas9	negative selection	6117051
37368509	37368532	6	+	27260156	CADOES1	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.6869102009486339	[406]	[595,686,537,616]	9	hSpCas9	negative selection	6174046
37368479	37368502	6	+	27260156	CADOES1	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	0.2129726305805606	[224]	[208,202,345,210]	3	hSpCas9	negative selection	6174047
37360440	37360463	6	+	27260156	CADOES1	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.30415194979171856	[247]	[193,158,236,155]	-5	hSpCas9	negative selection	6174048
37360463	37360486	6	+	27260156	CADOES1	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	0.07829453334201641	[42]	[24,67,58,15]	1	hSpCas9	negative selection	6238300
37374613	37374636	6	+	27260156	CADOES1	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.15035110930277168	[373]	[227,295,309,423]	-3	hSpCas9	negative selection	6238301
37374637	37374660	6	+	27260156	CADOES1	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.5704237481122691	[130]	[69,118,64,73]	-7	hSpCas9	negative selection	6238302
37368509	37368532	6	+	27260156	EWS502	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.6605272937107799	[406]	[624,700,682,722]	9	hSpCas9	negative selection	6295297
37368479	37368502	6	+	27260156	EWS502	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	-0.07857455729692564	[224]	[236,277,178,201]	-1	hSpCas9	negative selection	6295298
37360440	37360463	6	+	27260156	EWS502	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.29223389720486714	[247]	[174,222,251,211]	-5	hSpCas9	negative selection	6295299
37360463	37360486	6	+	27260156	EWS502	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-1.5736819795553383	[42]	[7,7,23,22]	-9	hSpCas9	negative selection	6359551
37374613	37374636	6	+	27260156	EWS502	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.17184842551203178	[373]	[212,264,374,589]	-3	hSpCas9	negative selection	6359552
37374637	37374660	6	+	27260156	EWS502	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.6985354545968983	[130]	[127,82,54,68]	-8	hSpCas9	negative selection	6359553
37368509	37368532	6	+	27260156	EW8	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.6919625145165925	[406]	[529,555,452,603]	9	hSpCas9	negative selection	6416548
37368479	37368502	6	+	27260156	EW8	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	-0.4078914076728777	[224]	[175,166,82,136]	-6	hSpCas9	negative selection	6416549
37360440	37360463	6	+	27260156	EW8	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.8110233865010293	[247]	[100,120,128,102]	-8	hSpCas9	negative selection	6416550
37360463	37360486	6	+	27260156	EW8	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-0.5504599674049504	[42]	[14,34,12,32]	-7	hSpCas9	negative selection	6480802
37374613	37374636	6	+	27260156	EW8	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.6165526531896821	[373]	[210,181,146,259]	-8	hSpCas9	negative selection	6480803
37374637	37374660	6	+	27260156	EW8	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	0.02868504938817229	[130]	[116,77,39,209]	0	hSpCas9	negative selection	6480804
37368509	37368532	6	+	27260156	CORL105	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.46869480210818926	[406]	[776,586,703,581]	8	hSpCas9	negative selection	6537799
37368479	37368502	6	+	27260156	CORL105	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	-0.14380672366420755	[224]	[153,179,386,253]	-3	hSpCas9	negative selection	6537800
37360440	37360463	6	+	27260156	CORL105	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.7629766213562758	[247]	[229,163,166,124]	-8	hSpCas9	negative selection	6537801
37360463	37360486	6	+	27260156	CORL105	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-1.1242767017051993	[42]	[50,13,6,18]	-9	hSpCas9	negative selection	6602053
37374613	37374636	6	+	27260156	CORL105	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.14767459934930505	[373]	[432,253,529,388]	-3	hSpCas9	negative selection	6602054
37374637	37374660	6	+	27260156	CORL105	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.2407761746376187	[130]	[81,228,93,104]	-4	hSpCas9	negative selection	6602055
37368509	37368532	6	+	27260156	HS294T	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	1.2965571095862802	[406]	[287,307,360,642]	9	hSpCas9	negative selection	6659050
37368479	37368502	6	+	27260156	HS294T	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	0.9832934446052612	[224]	[84,317,159,118]	9	hSpCas9	negative selection	6659051
37360440	37360463	6	+	27260156	HS294T	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.29346546269700335	[247]	[46,59,82,135]	-4	hSpCas9	negative selection	6659052
37360463	37360486	6	+	27260156	HS294T	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-1.5461212527420165	[42]	[5,3,5,6]	-9	hSpCas9	negative selection	6723304
37374613	37374636	6	+	27260156	HS294T	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.1076184954260948	[373]	[122,103,174,136]	-1	hSpCas9	negative selection	6723305
37374637	37374660	6	+	27260156	HS294T	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.20637595923717256	[130]	[30,35,45,67]	-3	hSpCas9	negative selection	6723306
37368509	37368532	6	+	27260156	HCC44	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.7714208524674102	[406]	[1124,510,997,614]	9	hSpCas9	negative selection	6780301
37368479	37368502	6	+	27260156	HCC44	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	-0.15906039947555328	[224]	[228,226,312,157]	-3	hSpCas9	negative selection	6780302
37360440	37360463	6	+	27260156	HCC44	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.6397244756491919	[247]	[139,230,227,118]	-7	hSpCas9	negative selection	6780303
37360463	37360486	6	+	27260156	HCC44	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-1.6124167053631804	[42]	[44,0,22,0]	-9	hSpCas9	negative selection	6844555
37374613	37374636	6	+	27260156	HCC44	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.013724396245102521	[373]	[552,281,527,361]	0	hSpCas9	negative selection	6844556
37374637	37374660	6	+	27260156	HCC44	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.3607403277095631	[130]	[181,63,129,100]	-5	hSpCas9	negative selection	6844557
37368509	37368532	6	+	27260156	G402	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.8241418646618058	[406]	[486,821,1505,649]	8	hSpCas9	negative selection	6901552
37368479	37368502	6	+	27260156	G402	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	0.014548290488870741	[224]	[354,201,363,197]	0	hSpCas9	negative selection	6901553
37360440	37360463	6	+	27260156	G402	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-1.0402253407960167	[247]	[200,147,187,62]	-8	hSpCas9	negative selection	6901554
37360463	37360486	6	+	27260156	G402	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-0.6085324914619439	[42]	[89,29,5,19]	-6	hSpCas9	negative selection	6965806
37374613	37374636	6	+	27260156	G402	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	0.32897304006535005	[373]	[513,525,508,722]	4	hSpCas9	negative selection	6965807
37374637	37374660	6	+	27260156	G402	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-1.2152879107583539	[130]	[50,50,68,98]	-8	hSpCas9	negative selection	6965808
37368509	37368532	6	+	27260156	L33	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.4133154988111152	[406]	[531,226,329,556]	8	hSpCas9	negative selection	7022803
37368479	37368502	6	+	27260156	L33	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	0.3353196047602123	[224]	[255,107,212,277]	7	hSpCas9	negative selection	7022804
37360440	37360463	6	+	27260156	L33	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.007308773780396072	[247]	[268,114,120,243]	0	hSpCas9	negative selection	7022805
37360463	37360486	6	+	27260156	L33	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-0.9463404431909477	[42]	[29,7,3,32]	-9	hSpCas9	negative selection	7087057
37374613	37374636	6	+	27260156	L33	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	0.19525044440942793	[373]	[375,202,301,362]	4	hSpCas9	negative selection	7087058
37374637	37374660	6	+	27260156	L33	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	0.4872733625805623	[130]	[234,59,121,157]	8	hSpCas9	negative selection	7087059
37368509	37368532	6	+	27260156	K562	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.6981562891395502	[406]	[741,682,580,377]	8	hSpCas9	negative selection	7144054
37368479	37368502	6	+	27260156	K562	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	0.22231760351811403	[224]	[246,562,120,40]	2	hSpCas9	negative selection	7144055
37360440	37360463	6	+	27260156	K562	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.9746826055150711	[247]	[65,142,139,97]	-8	hSpCas9	negative selection	7144056
37360463	37360486	6	+	27260156	K562	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-1.789337628215184	[42]	[0,7,2,28]	-9	hSpCas9	negative selection	7208308
37374613	37374636	6	+	27260156	K562	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.34199384272196204	[373]	[303,165,409,174]	-4	hSpCas9	negative selection	7208309
37374637	37374660	6	+	27260156	K562	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.5483381857352845	[130]	[153,85,50,37]	-6	hSpCas9	negative selection	7208310
37368509	37368532	6	+	27260156	HT29	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.39837840112833356	[406]	[533,637,801,622]	7	hSpCas9	negative selection	7265305
37368479	37368502	6	+	27260156	HT29	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	0.3498724807599157	[224]	[394,328,386,289]	6	hSpCas9	negative selection	7265306
37360440	37360463	6	+	27260156	HT29	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.09257097075859033	[247]	[398,208,361,174]	-2	hSpCas9	negative selection	7265307
37360463	37360486	6	+	27260156	HT29	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-2.0963563073268188	[42]	[34,0,13,0]	-9	hSpCas9	negative selection	7329559
37374613	37374636	6	+	27260156	HT29	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.16636464015474595	[373]	[451,348,514,311]	-3	hSpCas9	negative selection	7329560
37374637	37374660	6	+	27260156	HT29	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.3672876296417924	[130]	[166,94,118,113]	-6	hSpCas9	negative selection	7329561
37368509	37368532	6	+	27260156	MHHES1	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.4607468528278852	[406]	[820,777,559,433]	7	hSpCas9	negative selection	7386556
37368479	37368502	6	+	27260156	MHHES1	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	-0.5670809595365474	[224]	[180,189,94,207]	-8	hSpCas9	negative selection	7386557
37360440	37360463	6	+	27260156	MHHES1	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.4146693444946289	[247]	[243,378,190,72]	-7	hSpCas9	negative selection	7386558
37360463	37360486	6	+	27260156	MHHES1	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-0.7058366234208253	[42]	[40,63,9,11]	-8	hSpCas9	negative selection	7450810
37374613	37374636	6	+	27260156	MHHES1	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.8572174725275736	[373]	[288,140,171,302]	-9	hSpCas9	negative selection	7450811
37374637	37374660	6	+	27260156	MHHES1	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.37239540608088606	[130]	[130,95,94,127]	-6	hSpCas9	negative selection	7450812
37368509	37368532	6	+	27260156	MEWO	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.5944659702949728	[406]	[618,413,700]	9	hSpCas9	negative selection	7507807
37368479	37368502	6	+	27260156	MEWO	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	0.017168477984399022	[224]	[119,211,288]	0	hSpCas9	negative selection	7507808
37360440	37360463	6	+	27260156	MEWO	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.5571149187085699	[247]	[212,108,161]	-8	hSpCas9	negative selection	7507809
37360463	37360486	6	+	27260156	MEWO	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-0.7988519219278625	[42]	[41,27,2]	-9	hSpCas9	negative selection	7572061
37374613	37374636	6	+	27260156	MEWO	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.12022930733658782	[373]	[327,295,342]	-3	hSpCas9	negative selection	7572062
37374637	37374660	6	+	27260156	MEWO	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	0.006758396052134019	[130]	[156,109,108]	0	hSpCas9	negative selection	7572063
37368509	37368532	6	+	27260156	LNCAPCLONEFGC	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	1.0808396114433307	[406]	[801,760,875,694]	9	hSpCas9	negative selection	7629058
37368479	37368502	6	+	27260156	LNCAPCLONEFGC	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	0.23412657921472058	[224]	[237,216,257,249]	3	hSpCas9	negative selection	7629059
37360440	37360463	6	+	27260156	LNCAPCLONEFGC	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.5377041456276689	[247]	[161,99,205,161]	-7	hSpCas9	negative selection	7629060
37360463	37360486	6	+	27260156	LNCAPCLONEFGC	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-1.6024545848534149	[42]	[17,13,11,6]	-9	hSpCas9	negative selection	7693312
37374613	37374636	6	+	27260156	LNCAPCLONEFGC	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	0.1232464564047277	[373]	[372,420,427,258]	2	hSpCas9	negative selection	7693313
37374637	37374660	6	+	27260156	LNCAPCLONEFGC	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.4840605416550219	[130]	[60,97,71,105]	-6	hSpCas9	negative selection	7693314
37368509	37368532	6	+	27260156	PANC0327	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.705594520287121	[406]	[480,713,455,681]	8	hSpCas9	negative selection	7750309
37368479	37368502	6	+	27260156	PANC0327	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	-0.0985940176491138	[224]	[193,156,176,222]	-1	hSpCas9	negative selection	7750310
37360440	37360463	6	+	27260156	PANC0327	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.15067989723253616	[247]	[132,207,148,296]	-2	hSpCas9	negative selection	7750311
37360463	37360486	6	+	27260156	PANC0327	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-1.1401885911432728	[42]	[10,15,32,8]	-8	hSpCas9	negative selection	7814563
37374613	37374636	6	+	27260156	PANC0327	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	0.21496633584059843	[373]	[398,334,419,395]	3	hSpCas9	negative selection	7814564
37374637	37374660	6	+	27260156	PANC0327	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.09226746147447118	[130]	[151,117,105,62]	-1	hSpCas9	negative selection	7814565
37368509	37368532	6	+	27260156	NCIH2009	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.5219427104276232	[406]	[813,1016,612]	7	hSpCas9	negative selection	7871560
37368479	37368502	6	+	27260156	NCIH2009	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	-1.9848035432553421	[224]	[133,74,39]	-9	hSpCas9	negative selection	7871561
37360440	37360463	6	+	27260156	NCIH2009	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-1.3451606991315943	[247]	[180,121,114]	-8	hSpCas9	negative selection	7871562
37360463	37360486	6	+	27260156	NCIH2009	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-2.3119983843259075	[42]	[20,13,2]	-9	hSpCas9	negative selection	7935814
37374613	37374636	6	+	27260156	NCIH2009	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.08749096964522618	[373]	[314,358,767]	-1	hSpCas9	negative selection	7935815
37374637	37374660	6	+	27260156	NCIH2009	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.9191693854917478	[130]	[142,59,96]	-8	hSpCas9	negative selection	7935816
37368509	37368532	6	+	27260156	NCIH1373	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.900757974646938	[406]	[1064,811,541,272]	8	hSpCas9	negative selection	7992811
37368479	37368502	6	+	27260156	NCIH1373	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	-0.09591466648868252	[224]	[333,110,229,78]	-1	hSpCas9	negative selection	7992812
37360440	37360463	6	+	27260156	NCIH1373	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.30737993213239834	[247]	[116,277,180,79]	-3	hSpCas9	negative selection	7992813
37360463	37360486	6	+	27260156	NCIH1373	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-1.2048865919496863	[42]	[3,13,50,2]	-8	hSpCas9	negative selection	8057065
37374613	37374636	6	+	27260156	NCIH1373	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	0.1742040894239277	[373]	[617,492,434,93]	1	hSpCas9	negative selection	8057066
37374637	37374660	6	+	27260156	NCIH1373	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	0.46360647167026925	[130]	[318,188,130,49]	4	hSpCas9	negative selection	8057067
37368509	37368532	6	+	27260156	PATU8902	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	-0.021700680490933905	[406]	[813,565,413,456]	0	hSpCas9	negative selection	8114062
37368479	37368502	6	+	27260156	PATU8902	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	-0.33453969354512614	[224]	[442,271,160,120]	-3	hSpCas9	negative selection	8114063
37360440	37360463	6	+	27260156	PATU8902	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.36678136619042456	[247]	[280,366,241,174]	-4	hSpCas9	negative selection	8114064
37360463	37360486	6	+	27260156	PATU8902	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	0.16784163228229598	[42]	[175,1,54,32]	1	hSpCas9	negative selection	8178316
37374613	37374636	6	+	27260156	PATU8902	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.5069866284940023	[373]	[312,734,266,149]	-5	hSpCas9	negative selection	8178317
37374637	37374660	6	+	27260156	PATU8902	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-2.1584599271316556	[130]	[47,3,86,7]	-9	hSpCas9	negative selection	8178318
37368509	37368532	6	+	27260156	PANC1	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.5941173000032626	[406]	[487,525,714,396]	8	hSpCas9	negative selection	8235313
37368479	37368502	6	+	27260156	PANC1	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	0.3789516766294818	[224]	[142,437,265,202]	6	hSpCas9	negative selection	8235314
37360440	37360463	6	+	27260156	PANC1	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.023105662290285323	[247]	[163,202,330,147]	0	hSpCas9	negative selection	8235315
37360463	37360486	6	+	27260156	PANC1	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-0.7934451194580876	[42]	[2,89,3,4]	-8	hSpCas9	negative selection	8299567
37374613	37374636	6	+	27260156	PANC1	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	0.15190648482946092	[373]	[341,632,277,243]	2	hSpCas9	negative selection	8299568
37374637	37374660	6	+	27260156	PANC1	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.7491085183368089	[130]	[80,107,15,68]	-8	hSpCas9	negative selection	8299569
37368509	37368532	6	+	27260156	PANC0813	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.49611289814508874	[406]	[813,637,641,617]	7	hSpCas9	negative selection	8356564
37368479	37368502	6	+	27260156	PANC0813	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	0.059031933551043414	[224]	[399,224,243,244]	1	hSpCas9	negative selection	8356565
37360440	37360463	6	+	27260156	PANC0813	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.14729353447687055	[247]	[219,272,276,276]	-2	hSpCas9	negative selection	8356566
37360463	37360486	6	+	27260156	PANC0813	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-0.7372697397965298	[42]	[26,16,64,12]	-8	hSpCas9	negative selection	8420818
37374613	37374636	6	+	27260156	PANC0813	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.10376634667716783	[373]	[468,409,404,358]	-2	hSpCas9	negative selection	8420819
37374637	37374660	6	+	27260156	PANC0813	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	0.3588123681531443	[130]	[129,301,264,91]	6	hSpCas9	negative selection	8420820
37368509	37368532	6	+	27260156	RDES	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.8037980228940459	[406]	[688,864,745,988]	9	hSpCas9	negative selection	8477815
37368479	37368502	6	+	27260156	RDES	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	-0.09327050117337721	[224]	[127,194,327,364]	-1	hSpCas9	negative selection	8477816
37360440	37360463	6	+	27260156	RDES	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	0.022267625234617117	[247]	[176,320,283,407]	0	hSpCas9	negative selection	8477817
37360463	37360486	6	+	27260156	RDES	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-1.3688004522653787	[42]	[16,15,9,35]	-9	hSpCas9	negative selection	8542069
37374613	37374636	6	+	27260156	RDES	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.2369709143739112	[373]	[304,323,378,474]	-4	hSpCas9	negative selection	8542070
37374637	37374660	6	+	27260156	RDES	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	0.04462384831691635	[130]	[90,144,155,255]	0	hSpCas9	negative selection	8542071
37368509	37368532	6	+	27260156	PC3	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.5952060593431676	[406]	[441,424,1321,555]	9	hSpCas9	negative selection	8599066
37368479	37368502	6	+	27260156	PC3	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	-0.012528967045815298	[224]	[87,270,356,268]	0	hSpCas9	negative selection	8599067
37360440	37360463	6	+	27260156	PC3	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-1.0061093938938246	[247]	[67,92,251,145]	-9	hSpCas9	negative selection	8599068
37360463	37360486	6	+	27260156	PC3	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-1.5407331839819753	[42]	[10,14,33,5]	-9	hSpCas9	negative selection	8663320
37374613	37374636	6	+	27260156	PC3	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.044070359572836504	[373]	[171,390,495,498]	-1	hSpCas9	negative selection	8663321
37374637	37374660	6	+	27260156	PC3	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	0.21694036279841433	[130]	[77,121,441,97]	5	hSpCas9	negative selection	8663322
37368509	37368532	6	+	27260156	PATU8988T	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.7748702867946409	[406]	[857,486,464,883]	9	hSpCas9	negative selection	8720317
37368479	37368502	6	+	27260156	PATU8988T	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	-0.1214515245762533	[224]	[233,214,176,172]	-2	hSpCas9	negative selection	8720318
37360440	37360463	6	+	27260156	PATU8988T	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.8572421827140096	[247]	[143,95,127,159]	-8	hSpCas9	negative selection	8720319
37360463	37360486	6	+	27260156	PATU8988T	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-1.2345757857962592	[42]	[15,5,3,45]	-9	hSpCas9	negative selection	8784571
37374613	37374636	6	+	27260156	PATU8988T	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.4222242874578935	[373]	[468,288,109,209]	-6	hSpCas9	negative selection	8784572
37374637	37374660	6	+	27260156	PATU8988T	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.028229843109375485	[130]	[193,85,112,97]	0	hSpCas9	negative selection	8784573
37368509	37368532	6	+	27260156	T47D	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.5359763880802014	[406]	[710,647,643,752]	9	hSpCas9	negative selection	8841568
37368479	37368502	6	+	27260156	T47D	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	0.2266172175214045	[224]	[256,295,254,423]	5	hSpCas9	negative selection	8841569
37360440	37360463	6	+	27260156	T47D	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.13425909929975333	[247]	[299,268,224,258]	-3	hSpCas9	negative selection	8841570
37360463	37360486	6	+	27260156	T47D	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-0.5256324939031614	[42]	[26,37,34,38]	-8	hSpCas9	negative selection	8905822
37374613	37374636	6	+	27260156	T47D	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.020983550903464654	[373]	[381,415,459,460]	0	hSpCas9	negative selection	8905823
37374637	37374660	6	+	27260156	T47D	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	0.03792197875603298	[130]	[200,143,114,168]	0	hSpCas9	negative selection	8905824
37368509	37368532	6	+	27260156	SU8686	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.44989423601748607	[406]	[586,438,663,518]	7	hSpCas9	negative selection	8962819
37368479	37368502	6	+	27260156	SU8686	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	0.21678012618591858	[224]	[256,242,271,266]	3	hSpCas9	negative selection	8962820
37360440	37360463	6	+	27260156	SU8686	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.8090502332901744	[247]	[119,89,142,230]	-8	hSpCas9	negative selection	8962821
37360463	37360486	6	+	27260156	SU8686	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-1.616696186544622	[42]	[13,10,22,6]	-9	hSpCas9	negative selection	9027073
37374613	37374636	6	+	27260156	SU8686	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	0.21259151330972403	[373]	[335,452,389,564]	3	hSpCas9	negative selection	9027074
37374637	37374660	6	+	27260156	SU8686	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.2360143346185437	[130]	[172,111,58,82]	-4	hSpCas9	negative selection	9027075
37368509	37368532	6	+	27260156	SKES1	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.32662999453563524	[406]	[672,393,488,486]	6	hSpCas9	negative selection	9084070
37368479	37368502	6	+	27260156	SKES1	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	-0.21961331170052123	[224]	[225,129,240,170]	-5	hSpCas9	negative selection	9084071
37360440	37360463	6	+	27260156	SKES1	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.33368983413689646	[247]	[240,156,224,164]	-6	hSpCas9	negative selection	9084072
37360463	37360486	6	+	27260156	SKES1	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-0.8289196304540414	[42]	[0,61,32,3]	-9	hSpCas9	negative selection	9148324
37374613	37374636	6	+	27260156	SKES1	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.14692817833620336	[373]	[351,333,404,262]	-3	hSpCas9	negative selection	9148325
37374637	37374660	6	+	27260156	SKES1	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.5128860459443343	[130]	[53,101,70,129]	-8	hSpCas9	negative selection	9148326
37368509	37368532	6	+	27260156	TOV112D	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.39110001686020157	[406]	[439,613,416,673]	7	hSpCas9	negative selection	9205321
37368479	37368502	6	+	27260156	TOV112D	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	-0.25226841874957673	[224]	[165,303,167,145]	-5	hSpCas9	negative selection	9205322
37360440	37360463	6	+	27260156	TOV112D	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.5914591178307286	[247]	[199,149,200,108]	-8	hSpCas9	negative selection	9205323
37360463	37360486	6	+	27260156	TOV112D	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-1.2417169290727483	[42]	[4,66,3,7]	-9	hSpCas9	negative selection	9269575
37374613	37374636	6	+	27260156	TOV112D	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.30888459903874227	[373]	[209,397,321,294]	-6	hSpCas9	negative selection	9269576
37374637	37374660	6	+	27260156	TOV112D	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.33952668176556355	[130]	[62,147,104,105]	-6	hSpCas9	negative selection	9269577
37368509	37368532	6	+	27260156	TC71	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.4332998404904164	[406]	[603,538,552,665]	8	hSpCas9	negative selection	9326572
37368479	37368502	6	+	27260156	TC71	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	0.069149158968414	[224]	[259,256,264,227]	1	hSpCas9	negative selection	9326573
37360440	37360463	6	+	27260156	TC71	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.1111123155629613	[247]	[261,241,219,261]	-3	hSpCas9	negative selection	9326574
37360463	37360486	6	+	27260156	TC71	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-0.44613636980317306	[42]	[29,29,42,31]	-8	hSpCas9	negative selection	9390826
37374613	37374636	6	+	27260156	TC71	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.03839633560681627	[373]	[365,424,413,353]	-1	hSpCas9	negative selection	9390827
37374637	37374660	6	+	27260156	TC71	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.2082932604179144	[130]	[96,133,126,128]	-5	hSpCas9	negative selection	9390828
37368509	37368532	6	+	27260156	TC32	viability	GAGCGCGTCTGGAACCTTTAAGG	RNF8	ENSG00000112130	0.18240452679047872	[406]	[402,263,644,508]	3	hSpCas9	negative selection	9447823
37368479	37368502	6	+	27260156	TC32	viability	CCCAGAGTCTAAATGGTGTTTGG	RNF8	ENSG00000112130	-0.05651240281876824	[224]	[94,290,157,228]	-1	hSpCas9	negative selection	9447824
37360440	37360463	6	+	27260156	TC32	viability	TCCCAGGTGACTGTAGGACGAGG	RNF8	ENSG00000112130	-0.07278374514131392	[247]	[200,181,307,213]	-1	hSpCas9	negative selection	9447825
37360463	37360486	6	+	27260156	TC32	viability	ATTTGGTGTCACATACCAACTGG	RNF8	ENSG00000112130	-0.4207341412617973	[42]	[7,45,49,13]	-7	hSpCas9	negative selection	9512077
37374613	37374636	6	+	27260156	TC32	viability	TTTGCAGCATTGGGCTCTAATGG	RNF8	ENSG00000112130	-0.27648962275375605	[373]	[293,195,384,321]	-5	hSpCas9	negative selection	9512078
37374637	37374660	6	+	27260156	TC32	viability	AGAGCTAAATCGCAGCAAGAAGG	RNF8	ENSG00000112130	-0.03567419418838469	[130]	[107,85,135,162]	0	hSpCas9	negative selection	9512079
37354183	37354206	6	+	27869803	HPAFII	viability after 27 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	-2.0621865862306468	[446]	[70,43,NaN]	-8	hSpCas9	negative selection	9595814
37359190	37359213	6	+	27869803	HPAFII	viability after 27 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	0.4980503214522684	[190]	[239,59,NaN]	4	hSpCas9	negative selection	9595815
37360499	37360522	6	-	27869803	HPAFII	viability after 27 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-1.614313324453567	[98]	[10,21,NaN]	-7	hSpCas9	negative selection	9595816
37368873	37368896	6	+	27869803	HPAFII	viability after 27 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-0.9941311452079216	[506]	[111,151,NaN]	-6	hSpCas9	negative selection	9595817
37368998	37369021	6	-	27869803	HPAFII	viability after 27 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-0.42322761788272034	[210]	[7,144,NaN]	-3	hSpCas9	negative selection	9595818
37371535	37371558	6	+	27869803	HPAFII	viability after 27 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	-0.5878851991759217	[104]	[27,43,NaN]	-4	hSpCas9	negative selection	9595819
37354183	37354206	6	+	27869803	HPAFII	viability after 15 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	-0.6737152268149614	[446]	[413,230,NaN]	-6	hSpCas9	negative selection	9678263
37359190	37359213	6	+	27869803	HPAFII	viability after 15 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	0.5375686656709854	[190]	[395,236,NaN]	6	hSpCas9	negative selection	9678264
37360499	37360522	6	-	27869803	HPAFII	viability after 15 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-2.066614453155718	[98]	[17,29,NaN]	-9	hSpCas9	negative selection	9678265
37368873	37368896	6	+	27869803	HPAFII	viability after 15 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	0.14607960795775776	[506]	[782,490,NaN]	1	hSpCas9	negative selection	9678266
37368998	37369021	6	-	27869803	HPAFII	viability after 15 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-0.5041015435479433	[210]	[96,198,NaN]	-5	hSpCas9	negative selection	9678267
37371535	37371558	6	+	27869803	HPAFII	viability after 15 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	-0.5646019681487049	[104]	[79,73,NaN]	-6	hSpCas9	negative selection	9678268
37354183	37354206	6	+	27869803	ASPC1	viability after 36 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	-1.3521146257940868	[884]	[216,118,53]	-8	hSpCas9	negative selection	9760712
37359190	37359213	6	+	27869803	ASPC1	viability after 36 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	0.2846593235498592	[448]	[220,361,31]	3	hSpCas9	negative selection	9760713
37360499	37360522	6	-	27869803	ASPC1	viability after 36 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-2.6448204036965293	[146]	[11,4,7]	-9	hSpCas9	negative selection	9760714
37368873	37368896	6	+	27869803	ASPC1	viability after 36 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-0.5562516958794654	[1163]	[359,246,237]	-5	hSpCas9	negative selection	9760715
37368998	37369021	6	-	27869803	ASPC1	viability after 36 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-0.9716044734733873	[489]	[47,86,113]	-7	hSpCas9	negative selection	9760716
37371535	37371558	6	+	27869803	ASPC1	viability after 36 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	0.11151584487464028	[244]	[31,8,199]	1	hSpCas9	negative selection	9760717
37354183	37354206	6	+	27869803	PATU8988S	viability after 35 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	0.402288427816479	[842]	[320,576,NaN]	4	hSpCas9	negative selection	9843161
37359190	37359213	6	+	27869803	PATU8988S	viability after 35 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	-0.19382873461565053	[439]	[124,184,NaN]	-2	hSpCas9	negative selection	9843162
37360499	37360522	6	-	27869803	PATU8988S	viability after 35 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-1.4710694108010594	[147]	[21,20,NaN]	-8	hSpCas9	negative selection	9843163
37368873	37368896	6	+	27869803	PATU8988S	viability after 35 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	0.07674996196408701	[1093]	[544,383,NaN]	0	hSpCas9	negative selection	9843164
37368998	37369021	6	-	27869803	PATU8988S	viability after 35 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-0.26053711382165107	[453]	[212,91,NaN]	-3	hSpCas9	negative selection	9843165
37371535	37371558	6	+	27869803	PATU8988S	viability after 35 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	0.4971961289177941	[241]	[167,106,NaN]	5	hSpCas9	negative selection	9843166
37354183	37354206	6	+	27869803	PATU8988S	viability after 31 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	0.4764571339379088	[842]	[274,712,NaN]	6	hSpCas9	negative selection	9925610
37359190	37359213	6	+	27869803	PATU8988S	viability after 31 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	-0.5073334376737297	[439]	[78,179,NaN]	-5	hSpCas9	negative selection	9925611
37360499	37360522	6	-	27869803	PATU8988S	viability after 31 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-1.3346054722304452	[147]	[18,28,NaN]	-8	hSpCas9	negative selection	9925612
37368873	37368896	6	+	27869803	PATU8988S	viability after 31 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-0.023242170231836945	[1093]	[496,342,NaN]	0	hSpCas9	negative selection	9925613
37368998	37369021	6	-	27869803	PATU8988S	viability after 31 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	0.2125587765711705	[453]	[240,169,NaN]	2	hSpCas9	negative selection	9925614
37371535	37371558	6	+	27869803	PATU8988S	viability after 31 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	0.3683283075597823	[241]	[135,109,NaN]	4	hSpCas9	negative selection	9925615
37354183	37354206	6	+	27869803	HPAFII	viability after 35 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	-1.0282432040644882	[446]	[133,84,NaN]	-5	hSpCas9	negative selection	10008059
37359190	37359213	6	+	27869803	HPAFII	viability after 35 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	0.24890960129021597	[190]	[152,71,NaN]	1	hSpCas9	negative selection	10008060
37360499	37360522	6	-	27869803	HPAFII	viability after 35 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-3.021082903635266	[98]	[0,11,NaN]	-8	hSpCas9	negative selection	10008061
37368873	37368896	6	+	27869803	HPAFII	viability after 35 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-0.8650515681444049	[506]	[91,195,NaN]	-5	hSpCas9	negative selection	10008062
37368998	37369021	6	-	27869803	HPAFII	viability after 35 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	0.9733328447112378	[210]	[6,437,NaN]	6	hSpCas9	negative selection	10008063
37371535	37371558	6	+	27869803	HPAFII	viability after 35 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	-1.4974957059997358	[104]	[23,12,NaN]	-7	hSpCas9	negative selection	10008064
37354183	37354206	6	+	27869803	HPAFII	viability after 31 days	TTCGTCACAGGAGACCGCGCCGG	RNF8	ENSG00000112130	-1.8098799596687545	[446]	[94,45,NaN]	-7	hSpCas9	negative selection	10090508
37359190	37359213	6	+	27869803	HPAFII	viability after 31 days	ATGAACTAGACTGGTCCAACAGG	RNF8	ENSG00000112130	0.4119170656144767	[190]	[200,78,NaN]	3	hSpCas9	negative selection	10090509
37360499	37360522	6	-	27869803	HPAFII	viability after 31 days	GGTTTCGAGAAATCATCAGGGGG	RNF8	ENSG00000112130	-1.957321731536611	[98]	[9,18,NaN]	-8	hSpCas9	negative selection	10090510
37368873	37368896	6	+	27869803	HPAFII	viability after 31 days	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-0.2310548098430235	[506]	[184,304,NaN]	-1	hSpCas9	negative selection	10090511
37368998	37369021	6	-	27869803	HPAFII	viability after 31 days	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	0.016411995560556475	[210]	[2,246,NaN]	0	hSpCas9	negative selection	10090512
37371535	37371558	6	+	27869803	HPAFII	viability after 31 days	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	-0.8648620000022342	[104]	[17,47,NaN]	-5	hSpCas9	negative selection	10090513
37360520	37360543	6	-	28162770	P31FUJ	viability	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	0.9895902169220694	[14]	[34]	9	hSpCas9	negative selection	10226708
37368998	37369021	6	-	28162770	P31FUJ	viability	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	0.12342634809650277	[531]	[680]	1	hSpCas9	negative selection	10226709
37368873	37368896	6	+	28162770	P31FUJ	viability	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-0.9750044469467318	[275]	[164]	-6	hSpCas9	negative selection	10226710
37371535	37371558	6	+	28162770	P31FUJ	viability	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	0.9228031257108671	[179]	[400]	9	hSpCas9	negative selection	10226711
37376934	37376957	6	+	28162770	P31FUJ	viability	GGAGAAGATGCAAGCACAGAAGG	RNF8	ENSG00000112130	-0.07526092742789858	[51]	[57]	0	hSpCas9	negative selection	10226712
37354186	37354209	6	+	28162770	P31FUJ	viability	GTCACAGGAGACCGCGCCGGTGG	RNF8	ENSG00000112130	-0.18549648963602228	[59]	[61]	-2	hSpCas9	negative selection	10226713
37368574	37368597	6	-	28162770	P31FUJ	viability	GCATTCTCCTTATTTTCCAGAGG	RNF8	ENSG00000112130	0.6296942718356864	[120]	[219]	7	hSpCas9	negative selection	10226714
37368889	37368912	6	+	28162770	P31FUJ	viability	ACAGGGGCTCCCATTTACCCTGG	RNF8	ENSG00000112130	0.30606388171732346	[158]	[230]	3	hSpCas9	negative selection	10226715
37371517	37371540	6	+	28162770	P31FUJ	viability	GGAGATAGCCCAAGGAGAAAAGG	RNF8	ENSG00000112130	0.6010535337578329	[261]	[466]	7	hSpCas9	negative selection	10226716
37368909	37368932	6	+	28162770	P31FUJ	viability	TGGCTTCCCCAAAGTCACAGAGG	RNF8	ENSG00000112130	-0.5485780723201457	[116]	[93]	-4	hSpCas9	negative selection	10226717
37360520	37360543	6	-	28162770	TF1	viability	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	NaN	[NaN]	[20]	1	hSpCas9	negative selection	10396074
37368998	37369021	6	-	28162770	TF1	viability	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	NaN	[NaN]	[435]	1	hSpCas9	negative selection	10396075
37368873	37368896	6	+	28162770	TF1	viability	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	NaN	[NaN]	[124]	1	hSpCas9	negative selection	10396076
37371535	37371558	6	+	28162770	TF1	viability	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	NaN	[NaN]	[222]	1	hSpCas9	negative selection	10396077
37376934	37376957	6	+	28162770	TF1	viability	GGAGAAGATGCAAGCACAGAAGG	RNF8	ENSG00000112130	NaN	[NaN]	[8]	1	hSpCas9	negative selection	10396078
37354186	37354209	6	+	28162770	TF1	viability	GTCACAGGAGACCGCGCCGGTGG	RNF8	ENSG00000112130	NaN	[NaN]	[37]	1	hSpCas9	negative selection	10396079
37368574	37368597	6	-	28162770	TF1	viability	GCATTCTCCTTATTTTCCAGAGG	RNF8	ENSG00000112130	NaN	[NaN]	[26]	1	hSpCas9	negative selection	10396080
37368889	37368912	6	+	28162770	TF1	viability	ACAGGGGCTCCCATTTACCCTGG	RNF8	ENSG00000112130	NaN	[NaN]	[57]	1	hSpCas9	negative selection	10396081
37371517	37371540	6	+	28162770	TF1	viability	GGAGATAGCCCAAGGAGAAAAGG	RNF8	ENSG00000112130	NaN	[NaN]	[130]	1	hSpCas9	negative selection	10396082
37368909	37368932	6	+	28162770	TF1	viability	TGGCTTCCCCAAAGTCACAGAGG	RNF8	ENSG00000112130	NaN	[NaN]	[70]	1	hSpCas9	negative selection	10396083
37360520	37360543	6	-	28162770	SKM1	viability	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	-2.6964708159381465	[10]	[2]	-9	hSpCas9	negative selection	10565440
37368998	37369021	6	-	28162770	SKM1	viability	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-0.6155508205545789	[142]	[164]	-5	hSpCas9	negative selection	10565441
37368873	37368896	6	+	28162770	SKM1	viability	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	0.1779983019779944	[43]	[87]	1	hSpCas9	negative selection	10565442
37371535	37371558	6	+	28162770	SKM1	viability	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	-0.11012708481862998	[57]	[94]	-1	hSpCas9	negative selection	10565443
37376934	37376957	6	+	28162770	SKM1	viability	GGAGAAGATGCAAGCACAGAAGG	RNF8	ENSG00000112130	-3.0443941193584534	[13]	[2]	-9	hSpCas9	negative selection	10565444
37354186	37354209	6	+	28162770	SKM1	viability	GTCACAGGAGACCGCGCCGGTGG	RNF8	ENSG00000112130	-0.26560834949762	[16]	[24]	-2	hSpCas9	negative selection	10565445
37368574	37368597	6	-	28162770	SKM1	viability	GCATTCTCCTTATTTTCCAGAGG	RNF8	ENSG00000112130	-0.30742852519224717	[34]	[49]	-3	hSpCas9	negative selection	10565446
37368889	37368912	6	+	28162770	SKM1	viability	ACAGGGGCTCCCATTTACCCTGG	RNF8	ENSG00000112130	0.8080486922276888	[20]	[64]	7	hSpCas9	negative selection	10565447
37371517	37371540	6	+	28162770	SKM1	viability	GGAGATAGCCCAAGGAGAAAAGG	RNF8	ENSG00000112130	0.2014572748019836	[60]	[123]	2	hSpCas9	negative selection	10565448
37368909	37368932	6	+	28162770	SKM1	viability	TGGCTTCCCCAAAGTCACAGAGG	RNF8	ENSG00000112130	-1.6964708159381465	[21]	[11]	-8	hSpCas9	negative selection	10565449
37360520	37360543	6	-	28162770	SKM1	viability	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	-2.6964708159381465	[10]	[2]	-9	hSpCas9	negative selection	10734806
37368998	37369021	6	-	28162770	SKM1	viability	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-0.6155508205545789	[142]	[164]	-5	hSpCas9	negative selection	10734807
37368873	37368896	6	+	28162770	SKM1	viability	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	0.1779983019779944	[43]	[87]	1	hSpCas9	negative selection	10734808
37371535	37371558	6	+	28162770	SKM1	viability	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	-0.11012708481862998	[57]	[94]	-1	hSpCas9	negative selection	10734809
37376934	37376957	6	+	28162770	SKM1	viability	GGAGAAGATGCAAGCACAGAAGG	RNF8	ENSG00000112130	-3.0443941193584534	[13]	[2]	-9	hSpCas9	negative selection	10734810
37354186	37354209	6	+	28162770	SKM1	viability	GTCACAGGAGACCGCGCCGGTGG	RNF8	ENSG00000112130	-0.26560834949762	[16]	[24]	-2	hSpCas9	negative selection	10734811
37368574	37368597	6	-	28162770	SKM1	viability	GCATTCTCCTTATTTTCCAGAGG	RNF8	ENSG00000112130	-0.30742852519224717	[34]	[49]	-3	hSpCas9	negative selection	10734812
37368889	37368912	6	+	28162770	SKM1	viability	ACAGGGGCTCCCATTTACCCTGG	RNF8	ENSG00000112130	0.8080486922276888	[20]	[64]	7	hSpCas9	negative selection	10734813
37371517	37371540	6	+	28162770	SKM1	viability	GGAGATAGCCCAAGGAGAAAAGG	RNF8	ENSG00000112130	0.2014572748019836	[60]	[123]	2	hSpCas9	negative selection	10734814
37368909	37368932	6	+	28162770	SKM1	viability	TGGCTTCCCCAAAGTCACAGAGG	RNF8	ENSG00000112130	-1.6964708159381465	[21]	[11]	-8	hSpCas9	negative selection	10734815
37360520	37360543	6	-	28162770	PL21	viability	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	-4.259292004147977	[43]	[0]	-9	hSpCas9	negative selection	10904172
37368998	37369021	6	-	28162770	PL21	viability	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	0.1465436061615839	[520]	[250]	1	hSpCas9	negative selection	10904173
37368873	37368896	6	+	28162770	PL21	viability	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-0.5498821325023323	[184]	[54]	-4	hSpCas9	negative selection	10904174
37371535	37371558	6	+	28162770	PL21	viability	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	0.3029880220810704	[202]	[108]	2	hSpCas9	negative selection	10904175
37376934	37376957	6	+	28162770	PL21	viability	GGAGAAGATGCAAGCACAGAAGG	RNF8	ENSG00000112130	-0.8237071274650474	[60]	[14]	-5	hSpCas9	negative selection	10904176
37354186	37354209	6	+	28162770	PL21	viability	GTCACAGGAGACCGCGCCGGTGG	RNF8	ENSG00000112130	-2.5864567474014866	[68]	[4]	-9	hSpCas9	negative selection	10904177
37368574	37368597	6	-	28162770	PL21	viability	GCATTCTCCTTATTTTCCAGAGG	RNF8	ENSG00000112130	-0.513556200354039	[81]	[24]	-4	hSpCas9	negative selection	10904178
37368889	37368912	6	+	28162770	PL21	viability	ACAGGGGCTCCCATTTACCCTGG	RNF8	ENSG00000112130	0.2116352533271496	[124]	[62]	1	hSpCas9	negative selection	10904179
37371517	37371540	6	+	28162770	PL21	viability	GGAGATAGCCCAAGGAGAAAAGG	RNF8	ENSG00000112130	-0.1527414087269541	[211]	[82]	-1	hSpCas9	negative selection	10904180
37368909	37368932	6	+	28162770	PL21	viability	TGGCTTCCCCAAAGTCACAGAGG	RNF8	ENSG00000112130	-1.754056695897555	[61]	[7]	-8	hSpCas9	negative selection	10904181
37360520	37360543	6	-	28162770	P31FUJ	viability	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	0.9895902169220694	[14]	[34]	9	hSpCas9	negative selection	11073538
37368998	37369021	6	-	28162770	P31FUJ	viability	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	0.12342634809650277	[531]	[680]	1	hSpCas9	negative selection	11073539
37368873	37368896	6	+	28162770	P31FUJ	viability	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-0.9750044469467318	[275]	[164]	-6	hSpCas9	negative selection	11073540
37371535	37371558	6	+	28162770	P31FUJ	viability	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	0.9228031257108671	[179]	[400]	9	hSpCas9	negative selection	11073541
37376934	37376957	6	+	28162770	P31FUJ	viability	GGAGAAGATGCAAGCACAGAAGG	RNF8	ENSG00000112130	-0.07526092742789858	[51]	[57]	0	hSpCas9	negative selection	11073542
37354186	37354209	6	+	28162770	P31FUJ	viability	GTCACAGGAGACCGCGCCGGTGG	RNF8	ENSG00000112130	-0.18549648963602228	[59]	[61]	-2	hSpCas9	negative selection	11073543
37368574	37368597	6	-	28162770	P31FUJ	viability	GCATTCTCCTTATTTTCCAGAGG	RNF8	ENSG00000112130	0.6296942718356864	[120]	[219]	7	hSpCas9	negative selection	11073544
37368889	37368912	6	+	28162770	P31FUJ	viability	ACAGGGGCTCCCATTTACCCTGG	RNF8	ENSG00000112130	0.30606388171732346	[158]	[230]	3	hSpCas9	negative selection	11073545
37371517	37371540	6	+	28162770	P31FUJ	viability	GGAGATAGCCCAAGGAGAAAAGG	RNF8	ENSG00000112130	0.6010535337578329	[261]	[466]	7	hSpCas9	negative selection	11073546
37368909	37368932	6	+	28162770	P31FUJ	viability	TGGCTTCCCCAAAGTCACAGAGG	RNF8	ENSG00000112130	-0.5485780723201457	[116]	[93]	-4	hSpCas9	negative selection	11073547
37360520	37360543	6	-	28162770	OCIAML5	viability	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	-2.2305781941177267	[12]	[4]	-8	hSpCas9	negative selection	11242904
37368998	37369021	6	-	28162770	OCIAML5	viability	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-0.83594690550072	[355]	[359]	-5	hSpCas9	negative selection	11242905
37368873	37368896	6	+	28162770	OCIAML5	viability	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-0.4511871345818126	[127]	[168]	-3	hSpCas9	negative selection	11242906
37371535	37371558	6	+	28162770	OCIAML5	viability	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	0.7289160789446141	[120]	[361]	6	hSpCas9	negative selection	11242907
37376934	37376957	6	+	28162770	OCIAML5	viability	GGAGAAGATGCAAGCACAGAAGG	RNF8	ENSG00000112130	-0.5764321282505693	[18]	[22]	-4	hSpCas9	negative selection	11242908
37354186	37354209	6	+	28162770	OCIAML5	viability	GTCACAGGAGACCGCGCCGGTGG	RNF8	ENSG00000112130	-0.2671040701428411	[15]	[23]	-2	hSpCas9	negative selection	11242909
37368574	37368597	6	-	28162770	OCIAML5	viability	GCATTCTCCTTATTTTCCAGAGG	RNF8	ENSG00000112130	-0.20754722546238596	[86]	[135]	-1	hSpCas9	negative selection	11242910
37368889	37368912	6	+	28162770	OCIAML5	viability	ACAGGGGCTCCCATTTACCCTGG	RNF8	ENSG00000112130	-1.2827009251938595	[61]	[45]	-6	hSpCas9	negative selection	11242911
37371517	37371540	6	+	28162770	OCIAML5	viability	GGAGATAGCCCAAGGAGAAAAGG	RNF8	ENSG00000112130	0.32887142330073327	[115]	[262]	2	hSpCas9	negative selection	11242912
37368909	37368932	6	+	28162770	OCIAML5	viability	TGGCTTCCCCAAAGTCACAGAGG	RNF8	ENSG00000112130	-1.2721750596902628	[94]	[70]	-6	hSpCas9	negative selection	11242913
37360520	37360543	6	-	28162770	EOL1	viability	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	-1.0422853644942665	[42]	[10]	-6	hSpCas9	negative selection	11412270
37368998	37369021	6	-	28162770	EOL1	viability	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-1.2915856592942312	[459]	[98]	-7	hSpCas9	negative selection	11412271
37368873	37368896	6	+	28162770	EOL1	viability	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-1.219418002809097	[357]	[80]	-7	hSpCas9	negative selection	11412272
37371535	37371558	6	+	28162770	EOL1	viability	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	0.8308623260291006	[333]	[312]	7	hSpCas9	negative selection	11412273
37376934	37376957	6	+	28162770	EOL1	viability	GGAGAAGATGCAAGCACAGAAGG	RNF8	ENSG00000112130	-3.5084116357055715	[107]	[4]	-9	hSpCas9	negative selection	11412274
37354186	37354209	6	+	28162770	EOL1	viability	GTCACAGGAGACCGCGCCGGTGG	RNF8	ENSG00000112130	-2.599014184486478	[91]	[7]	-9	hSpCas9	negative selection	11412275
37368574	37368597	6	-	28162770	EOL1	viability	GCATTCTCCTTATTTTCCAGAGG	RNF8	ENSG00000112130	0.3738551729341246	[103]	[70]	3	hSpCas9	negative selection	11412276
37368889	37368912	6	+	28162770	EOL1	viability	ACAGGGGCTCCCATTTACCCTGG	RNF8	ENSG00000112130	-0.9461692114844991	[127]	[34]	-6	hSpCas9	negative selection	11412277
37371517	37371540	6	+	28162770	EOL1	viability	GGAGATAGCCCAAGGAGAAAAGG	RNF8	ENSG00000112130	-0.8072561174798929	[278]	[83]	-5	hSpCas9	negative selection	11412278
37368909	37368932	6	+	28162770	EOL1	viability	TGGCTTCCCCAAAGTCACAGAGG	RNF8	ENSG00000112130	-0.6604147291506217	[77]	[25]	-5	hSpCas9	negative selection	11412279
37360520	37360543	6	-	28162770	MOLM13	viability	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	-3.2869981206188896	[80]	[5]	-8	hSpCas9	negative selection	11581636
37368998	37369021	6	-	28162770	MOLM13	viability	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-1.0904789091648641	[644]	[218]	-5	hSpCas9	negative selection	11581637
37368873	37368896	6	+	28162770	MOLM13	viability	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-1.3004403835309626	[309]	[90]	-6	hSpCas9	negative selection	11581638
37371535	37371558	6	+	28162770	MOLM13	viability	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	-0.5228328048674102	[309]	[155]	-3	hSpCas9	negative selection	11581639
37376934	37376957	6	+	28162770	MOLM13	viability	GGAGAAGATGCAAGCACAGAAGG	RNF8	ENSG00000112130	-0.39270756179000443	[68]	[37]	-2	hSpCas9	negative selection	11581640
37354186	37354209	6	+	28162770	MOLM13	viability	GTCACAGGAGACCGCGCCGGTGG	RNF8	ENSG00000112130	0.974074768881618	[68]	[97]	7	hSpCas9	negative selection	11581641
37368574	37368597	6	-	28162770	MOLM13	viability	GCATTCTCCTTATTTTCCAGAGG	RNF8	ENSG00000112130	-0.6175021096860659	[173]	[81]	-4	hSpCas9	negative selection	11581642
37368889	37368912	6	+	28162770	MOLM13	viability	ACAGGGGCTCCCATTTACCCTGG	RNF8	ENSG00000112130	-1.757285480463196	[172]	[36]	-7	hSpCas9	negative selection	11581643
37371517	37371540	6	+	28162770	MOLM13	viability	GGAGATAGCCCAAGGAGAAAAGG	RNF8	ENSG00000112130	-0.10071850632627524	[306]	[206]	0	hSpCas9	negative selection	11581644
37368909	37368932	6	+	28162770	MOLM13	viability	TGGCTTCCCCAAAGTCACAGAGG	RNF8	ENSG00000112130	-1.5660579503787588	[85]	[20]	-6	hSpCas9	negative selection	11581645
37360520	37360543	6	-	28162770	HEL	viability	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	-1.6202955738334368	[23]	[4]	-7	hSpCas9	negative selection	11751002
37368998	37369021	6	-	28162770	HEL	viability	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-0.6110177602454261	[557]	[233]	-4	hSpCas9	negative selection	11751003
37368873	37368896	6	+	28162770	HEL	viability	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-1.127779321876876	[289]	[84]	-6	hSpCas9	negative selection	11751004
37371535	37371558	6	+	28162770	HEL	viability	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	0.6377896160286236	[291]	[290]	5	hSpCas9	negative selection	11751005
37376934	37376957	6	+	28162770	HEL	viability	GGAGAAGATGCAAGCACAGAAGG	RNF8	ENSG00000112130	-1.3870085113936952	[48]	[11]	-7	hSpCas9	negative selection	11751006
37354186	37354209	6	+	28162770	HEL	viability	GTCACAGGAGACCGCGCCGGTGG	RNF8	ENSG00000112130	-0.8353084648042872	[77]	[27]	-5	hSpCas9	negative selection	11751007
37368574	37368597	6	-	28162770	HEL	viability	GCATTCTCCTTATTTTCCAGAGG	RNF8	ENSG00000112130	0.9494001702344088	[151]	[187]	8	hSpCas9	negative selection	11751008
37368889	37368912	6	+	28162770	HEL	viability	ACAGGGGCTCCCATTTACCCTGG	RNF8	ENSG00000112130	-1.5156905306041257	[124]	[27]	-7	hSpCas9	negative selection	11751009
37371517	37371540	6	+	28162770	HEL	viability	GGAGATAGCCCAAGGAGAAAAGG	RNF8	ENSG00000112130	-0.16607704718552724	[246]	[140]	-1	hSpCas9	negative selection	11751010
37368909	37368932	6	+	28162770	HEL	viability	TGGCTTCCCCAAAGTCACAGAGG	RNF8	ENSG00000112130	-0.43972332819161597	[71]	[33]	-3	hSpCas9	negative selection	11751011
37360520	37360543	6	-	28162770	MV411	viability	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	-2.288615349457434	[28]	[4]	-8	hSpCas9	negative selection	11920368
37368998	37369021	6	-	28162770	MV411	viability	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-0.7423184177204217	[420]	[211]	-5	hSpCas9	negative selection	11920369
37368873	37368896	6	+	28162770	MV411	viability	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-1.0336568265960095	[208]	[85]	-6	hSpCas9	negative selection	11920370
37371535	37371558	6	+	28162770	MV411	viability	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	0.4620943233396179	[186]	[216]	4	hSpCas9	negative selection	11920371
37376934	37376957	6	+	28162770	MV411	viability	GGAGAAGATGCAAGCACAGAAGG	RNF8	ENSG00000112130	-3.659453044825743	[59]	[3]	-9	hSpCas9	negative selection	11920372
37354186	37354209	6	+	28162770	MV411	viability	GTCACAGGAGACCGCGCCGGTGG	RNF8	ENSG00000112130	-2.9224874506595375	[53]	[5]	-9	hSpCas9	negative selection	11920373
37368574	37368597	6	-	28162770	MV411	viability	GCATTCTCCTTATTTTCCAGAGG	RNF8	ENSG00000112130	0.3145517466413124	[104]	[109]	2	hSpCas9	negative selection	11920374
37368889	37368912	6	+	28162770	MV411	viability	ACAGGGGCTCCCATTTACCCTGG	RNF8	ENSG00000112130	-1.4895280433834308	[79]	[23]	-7	hSpCas9	negative selection	11920375
37371517	37371540	6	+	28162770	MV411	viability	GGAGATAGCCCAAGGAGAAAAGG	RNF8	ENSG00000112130	-0.465681301429063	[199]	[121]	-3	hSpCas9	negative selection	11920376
37368909	37368932	6	+	28162770	MV411	viability	TGGCTTCCCCAAAGTCACAGAGG	RNF8	ENSG00000112130	0.4902940746789388	[59]	[70]	4	hSpCas9	negative selection	11920377
37360520	37360543	6	-	28162770	MONOMAC1	viability	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	0.38792565366160225	[13]	[20]	4	hSpCas9	negative selection	12089734
37368998	37369021	6	-	28162770	MONOMAC1	viability	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-0.3117154510957484	[300]	[277]	-3	hSpCas9	negative selection	12089735
37368873	37368896	6	+	28162770	MONOMAC1	viability	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	0.3372995805916344	[115]	[167]	3	hSpCas9	negative selection	12089736
37371535	37371558	6	+	28162770	MONOMAC1	viability	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	0.19354760849475114	[118]	[155]	2	hSpCas9	negative selection	12089737
37376934	37376957	6	+	28162770	MONOMAC1	viability	GGAGAAGATGCAAGCACAGAAGG	RNF8	ENSG00000112130	-1.1970368470595534	[35]	[17]	-7	hSpCas9	negative selection	12089738
37354186	37354209	6	+	28162770	MONOMAC1	viability	GTCACAGGAGACCGCGCCGGTGG	RNF8	ENSG00000112130	0.6544406282303581	[45]	[82]	6	hSpCas9	negative selection	12089739
37368574	37368597	6	-	28162770	MONOMAC1	viability	GCATTCTCCTTATTTTCCAGAGG	RNF8	ENSG00000112130	-0.4362245109389796	[71]	[60]	-4	hSpCas9	negative selection	12089740
37368889	37368912	6	+	28162770	MONOMAC1	viability	ACAGGGGCTCCCATTTACCCTGG	RNF8	ENSG00000112130	-0.1504942611225235	[60]	[62]	-1	hSpCas9	negative selection	12089741
37371517	37371540	6	+	28162770	MONOMAC1	viability	GGAGATAGCCCAAGGAGAAAAGG	RNF8	ENSG00000112130	0.06599755877424021	[99]	[119]	0	hSpCas9	negative selection	12089742
37368909	37368932	6	+	28162770	MONOMAC1	viability	TGGCTTCCCCAAAGTCACAGAGG	RNF8	ENSG00000112130	-0.45337660031933935	[42]	[35]	-4	hSpCas9	negative selection	12089743
37360520	37360543	6	-	28162770	OCIAML2	viability	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	-3.3775204208506797	[14]	[7]	-9	hSpCas9	negative selection	12259100
37368998	37369021	6	-	28162770	OCIAML2	viability	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-0.4479810862969612	[78]	[320]	-4	hSpCas9	negative selection	12259101
37368873	37368896	6	+	28162770	OCIAML2	viability	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-1.4083455469878188	[33]	[70]	-7	hSpCas9	negative selection	12259102
37371535	37371558	6	+	28162770	OCIAML2	viability	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	0.09068140741434955	[40]	[241]	0	hSpCas9	negative selection	12259103
37376934	37376957	6	+	28162770	OCIAML2	viability	GGAGAAGATGCAAGCACAGAAGG	RNF8	ENSG00000112130	-0.8461389603343679	[11]	[36]	-5	hSpCas9	negative selection	12259104
37354186	37354209	6	+	28162770	OCIAML2	viability	GTCACAGGAGACCGCGCCGGTGG	RNF8	ENSG00000112130	-1.885667324521005	[17]	[26]	-8	hSpCas9	negative selection	12259105
37368574	37368597	6	-	28162770	OCIAML2	viability	GCATTCTCCTTATTTTCCAGAGG	RNF8	ENSG00000112130	0.10427901081507213	[23]	[142]	1	hSpCas9	negative selection	12259106
37368889	37368912	6	+	28162770	OCIAML2	viability	ACAGGGGCTCCCATTTACCCTGG	RNF8	ENSG00000112130	-1.0747011489110223	[18]	[49]	-6	hSpCas9	negative selection	12259107
37371517	37371540	6	+	28162770	OCIAML2	viability	GGAGATAGCCCAAGGAGAAAAGG	RNF8	ENSG00000112130	0.1748742174140457	[34]	[218]	1	hSpCas9	negative selection	12259108
37368909	37368932	6	+	28162770	OCIAML2	viability	TGGCTTCCCCAAAGTCACAGAGG	RNF8	ENSG00000112130	-0.7336642310759549	[8]	[29]	-5	hSpCas9	negative selection	12259109
37360520	37360543	6	-	28162770	OCIAML3	viability	GATTCTGCTTCAAAACACAGTGG	RNF8	ENSG00000112130	-3.0090451396030073	[7]	[2]	-9	hSpCas9	negative selection	12428466
37368998	37369021	6	-	28162770	OCIAML3	viability	GAGCCTCAGAATCCTGGACATGG	RNF8	ENSG00000112130	-0.7513196451542785	[120]	[216]	-5	hSpCas9	negative selection	12428467
37368873	37368896	6	+	28162770	OCIAML3	viability	TGAGCCAAGTAAGACCACAGGGG	RNF8	ENSG00000112130	-0.6225767925209341	[50]	[99]	-5	hSpCas9	negative selection	12428468
37371535	37371558	6	+	28162770	OCIAML3	viability	AAAGGACCTGAAGCAACAGCTGG	RNF8	ENSG00000112130	0.33323601724052265	[60]	[231]	3	hSpCas9	negative selection	12428469
37376934	37376957	6	+	28162770	OCIAML3	viability	GGAGAAGATGCAAGCACAGAAGG	RNF8	ENSG00000112130	1.2503414892156426	[10]	[78]	9	hSpCas9	negative selection	12428470
37354186	37354209	6	+	28162770	OCIAML3	viability	GTCACAGGAGACCGCGCCGGTGG	RNF8	ENSG00000112130	-0.2720795454368008	[11]	[29]	-2	hSpCas9	negative selection	12428471
37368574	37368597	6	-	28162770	OCIAML3	viability	GCATTCTCCTTATTTTCCAGAGG	RNF8	ENSG00000112130	-1.9043477609363137	[30]	[24]	-8	hSpCas9	negative selection	12428472
37368889	37368912	6	+	28162770	OCIAML3	viability	ACAGGGGCTCCCATTTACCCTGG	RNF8	ENSG00000112130	-1.4459090013350293	[36]	[40]	-7	hSpCas9	negative selection	12428473
37371517	37371540	6	+	28162770	OCIAML3	viability	GGAGATAGCCCAAGGAGAAAAGG	RNF8	ENSG00000112130	-0.15343504893818183	[55]	[151]	-1	hSpCas9	negative selection	12428474
37368909	37368932	6	+	28162770	OCIAML3	viability	TGGCTTCCCCAAAGTCACAGAGG	RNF8	ENSG00000112130	-0.9617394248246505	[19]	[30]	-6	hSpCas9	negative selection	12428475