| 67429123 | 67429146 | 11 | + | 26472758 | Jiyoye | viability | TGTGGGACACTATGAAGAGGTGG | RPS6KB2 | ENSG00000175634 | -0.13135154622499834 | [320] | [220] | -1 | hSpCas9 | negative selection | 140292 | 67428991 | 67429014 | 11 | - | 26472758 | Jiyoye | viability | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 5.53645839845084 | [0] | [34] | 9 | hSpCas9 | negative selection | 140293 | 67428573 | 67428596 | 11 | + | 26472758 | Jiyoye | viability | GAGACGGAGGAAGGCAGCGAGGG | RPS6KB2 | ENSG00000175634 | 3.164605078231795 | [20] | [141] | 9 | hSpCas9 | negative selection | 140294 | 67428560 | 67428583 | 11 | + | 26472758 | Jiyoye | viability | TGATTTGGATTTGGAGACGGAGG | RPS6KB2 | ENSG00000175634 | 2.7048559301465582 | [11] | [58] | 9 | hSpCas9 | negative selection | 140295 | 67428602 | 67428625 | 11 | + | 26472758 | Jiyoye | viability | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | 3.3331748000620967 | [4] | [37] | 9 | hSpCas9 | negative selection | 140296 | 67429123 | 67429146 | 11 | + | 26472758 | KBM7 | viability | TGTGGGACACTATGAAGAGGTGG | RPS6KB2 | ENSG00000175634 | -0.4766656634885169 | [1060,826] | [297,332] | -4 | hSpCas9 | negative selection | 331410 | 67428991 | 67429014 | 11 | - | 26472758 | KBM7 | viability | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | -0.041995907140281674 | [362,307] | [186,121] | 0 | hSpCas9 | negative selection | 331411 | 67428573 | 67428596 | 11 | + | 26472758 | KBM7 | viability | GAGACGGAGGAAGGCAGCGAGGG | RPS6KB2 | ENSG00000175634 | -0.544523034331602 | [662,718] | [266,186] | -5 | hSpCas9 | negative selection | 331412 | 67428560 | 67428583 | 11 | + | 26472758 | KBM7 | viability | TGATTTGGATTTGGAGACGGAGG | RPS6KB2 | ENSG00000175634 | 1.5544767729600393 | [265,165] | [439,160] | 9 | hSpCas9 | negative selection | 331413 | 67428602 | 67428625 | 11 | + | 26472758 | KBM7 | viability | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | -0.10361906132469523 | [220,176] | [104,69] | -1 | hSpCas9 | negative selection | 331414 | 67429123 | 67429146 | 11 | + | 26472758 | Raji | viability | TGTGGGACACTATGAAGAGGTGG | RPS6KB2 | ENSG00000175634 | 0.3000286133159953 | [398] | [113] | 3 | hSpCas9 | negative selection | 522528 | 67428991 | 67429014 | 11 | - | 26472758 | Raji | viability | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 1.0791866435429474 | [154] | [75] | 8 | hSpCas9 | negative selection | 522529 | 67428573 | 67428596 | 11 | + | 26472758 | Raji | viability | GAGACGGAGGAAGGCAGCGAGGG | RPS6KB2 | ENSG00000175634 | -0.46677221039097383 | [398] | [66] | -4 | hSpCas9 | negative selection | 522530 | 67428560 | 67428583 | 11 | + | 26472758 | Raji | viability | TGATTTGGATTTGGAGACGGAGG | RPS6KB2 | ENSG00000175634 | 0.3265008246771864 | [188] | [54] | 3 | hSpCas9 | negative selection | 522531 | 67428602 | 67428625 | 11 | + | 26472758 | Raji | viability | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | -1.246253419241101 | [91] | [8] | -7 | hSpCas9 | negative selection | 522532 | 67429123 | 67429146 | 11 | + | 26472758 | K562 | viability | TGTGGGACACTATGAAGAGGTGG | RPS6KB2 | ENSG00000175634 | -0.7365229365178685 | [751] | [380] | -4 | hSpCas9 | negative selection | 713646 | 67428991 | 67429014 | 11 | - | 26472758 | K562 | viability | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.9735648173733538 | [221] | [367] | 7 | hSpCas9 | negative selection | 713647 | 67428573 | 67428596 | 11 | + | 26472758 | K562 | viability | GAGACGGAGGAAGGCAGCGAGGG | RPS6KB2 | ENSG00000175634 | -0.9896083941534044 | [580] | [246] | -5 | hSpCas9 | negative selection | 713648 | 67428560 | 67428583 | 11 | + | 26472758 | K562 | viability | TGATTTGGATTTGGAGACGGAGG | RPS6KB2 | ENSG00000175634 | 0.03420102027610117 | [176] | [152] | 0 | hSpCas9 | negative selection | 713649 | 67428602 | 67428625 | 11 | + | 26472758 | K562 | viability | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | -1.3856316625832474 | [129] | [41] | -6 | hSpCas9 | negative selection | 713650 | 67428544 | 67428567 | 11 | - | 26627737 | DLD1 | viability | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | -0.7519295426689114 | [366] | [46,93,64] | -6 | hSpCas9 | negative selection | 780540 | 67428991 | 67429014 | 11 | - | 26627737 | DLD1 | viability | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.26016504050015776 | [355] | [124,163,114] | 2 | hSpCas9 | negative selection | 780541 | 67429574 | 67429597 | 11 | + | 26627737 | DLD1 | viability | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | 0.36849443565052953 | [330] | [71,147,174] | 4 | hSpCas9 | negative selection | 780542 | 67428544 | 67428567 | 11 | - | 26627737 | GBM cells | viability after 5 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | -0.0830145521922962 | [237] | [102,137] | -1 | hSpCas9 | negative selection | 862855 | 67428991 | 67429014 | 11 | - | 26627737 | GBM cells | viability after 5 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.4370821641279005 | [187] | [123,148] | 6 | hSpCas9 | negative selection | 862856 | 67429574 | 67429597 | 11 | + | 26627737 | GBM cells | viability after 5 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | 0.3204470854573007 | [276] | [152,217] | 5 | hSpCas9 | negative selection | 862857 | 67428544 | 67428567 | 11 | - | 26627737 | GBM cells | viability after 13 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | 0.20574175522292587 | [237] | [138,156] | 2 | hSpCas9 | negative selection | 945170 | 67428991 | 67429014 | 11 | - | 26627737 | GBM cells | viability after 13 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.17871214041966182 | [187] | [131,101] | 2 | hSpCas9 | negative selection | 945171 | 67429574 | 67429597 | 11 | + | 26627737 | GBM cells | viability after 13 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | 0.17843813378064474 | [276] | [195,148] | 2 | hSpCas9 | negative selection | 945172 | 67428544 | 67428567 | 11 | - | 26627737 | GBM cells | viability after 21 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | 0.34365158369854315 | [237] | [173,154] | 3 | hSpCas9 | negative selection | 1027485 | 67428991 | 67429014 | 11 | - | 26627737 | GBM cells | viability after 21 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.43591023871261525 | [187] | [145,130] | 4 | hSpCas9 | negative selection | 1027486 | 67429574 | 67429597 | 11 | + | 26627737 | GBM cells | viability after 21 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | 0.13553101957561783 | [276] | [157,171] | 1 | hSpCas9 | negative selection | 1027487 | 67428544 | 67428567 | 11 | - | 26627737 | RPE1 | viability after 9 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | -0.20707566816537526 | [640] | [189,152] | -1 | hSpCas9 | negative selection | 1109800 | 67428991 | 67429014 | 11 | - | 26627737 | RPE1 | viability after 9 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.14375210961518514 | [694] | [180,316] | 1 | hSpCas9 | negative selection | 1109801 | 67429574 | 67429597 | 11 | + | 26627737 | RPE1 | viability after 9 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | -0.6868906480330933 | [1669] | [336,308] | -5 | hSpCas9 | negative selection | 1109802 | 67428544 | 67428567 | 11 | - | 26627737 | RPE1 | viability after 12 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | 0.1186048810511793 | [640] | [236,133] | 0 | hSpCas9 | negative selection | 1192115 | 67428991 | 67429014 | 11 | - | 26627737 | RPE1 | viability after 12 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.15825590586718666 | [694] | [203,212] | 1 | hSpCas9 | negative selection | 1192116 | 67429574 | 67429597 | 11 | + | 26627737 | RPE1 | viability after 12 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | -0.10640840770014393 | [1669] | [425,406] | 0 | hSpCas9 | negative selection | 1192117 | 67428544 | 67428567 | 11 | - | 26627737 | RPE1 | viability after 15 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | 0.5241230639294784 | [640] | [386,138] | 3 | hSpCas9 | negative selection | 1274430 | 67428991 | 67429014 | 11 | - | 26627737 | RPE1 | viability after 15 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.18919602689318224 | [694] | [271,177] | 1 | hSpCas9 | negative selection | 1274431 | 67429574 | 67429597 | 11 | + | 26627737 | RPE1 | viability after 15 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | -0.1668662465733436 | [1669] | [515,328] | -1 | hSpCas9 | negative selection | 1274432 | 67428544 | 67428567 | 11 | - | 26627737 | RPE1 | viability after 18 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | -0.3880477089383852 | [640] | [195,63] | -2 | hSpCas9 | negative selection | 1356745 | 67428991 | 67429014 | 11 | - | 26627737 | RPE1 | viability after 18 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.02619212208537966 | [694] | [219,159] | 0 | hSpCas9 | negative selection | 1356746 | 67429574 | 67429597 | 11 | + | 26627737 | RPE1 | viability after 18 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | -0.9173018526694334 | [1669] | [227,249] | -5 | hSpCas9 | negative selection | 1356747 | 67428544 | 67428567 | 11 | - | 26627737 | HeLa | viability after 8 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | 0.3646502271023836 | [153] | [176,47,55] | 3 | hSpCas9 | negative selection | 1439060 | 67428991 | 67429014 | 11 | - | 26627737 | HeLa | viability after 8 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 1.5009384521214222 | [301] | [233,576,280] | 9 | hSpCas9 | negative selection | 1439061 | 67429574 | 67429597 | 11 | + | 26627737 | HeLa | viability after 8 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | -0.6702653250718018 | [492] | [210,131,81] | -6 | hSpCas9 | negative selection | 1439062 | 67428544 | 67428567 | 11 | - | 26627737 | HeLa | viability after 12 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | 1.3482111935395042 | [153] | [248,82,164] | 8 | hSpCas9 | negative selection | 1521375 | 67428991 | 67429014 | 11 | - | 26627737 | HeLa | viability after 12 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.933278072809858 | [301] | [173,314,215] | 7 | hSpCas9 | negative selection | 1521376 | 67429574 | 67429597 | 11 | + | 26627737 | HeLa | viability after 12 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | -0.6342529954605891 | [492] | [233,81,85] | -5 | hSpCas9 | negative selection | 1521377 | 67428544 | 67428567 | 11 | - | 26627737 | HeLa | viability after 15 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | 1.6666569364925827 | [153] | [155,129,320] | 9 | hSpCas9 | negative selection | 1603690 | 67428991 | 67429014 | 11 | - | 26627737 | HeLa | viability after 15 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.42338005182761723 | [301] | [86,178,234] | 3 | hSpCas9 | negative selection | 1603691 | 67429574 | 67429597 | 11 | + | 26627737 | HeLa | viability after 15 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | -1.4648112038023897 | [492] | [91,87,34] | -8 | hSpCas9 | negative selection | 1603692 | 67428544 | 67428567 | 11 | - | 26627737 | HeLa | viability after 18 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | 1.6652192813082856 | [153] | [99,112,320] | 9 | hSpCas9 | negative selection | 1686005 | 67428991 | 67429014 | 11 | - | 26627737 | HeLa | viability after 18 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.42810713769862846 | [301] | [53,154,234] | 3 | hSpCas9 | negative selection | 1686006 | 67429574 | 67429597 | 11 | + | 26627737 | HeLa | viability after 18 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | -1.446788032557294 | [492] | [60,75,34] | -8 | hSpCas9 | negative selection | 1686007 | 67428544 | 67428567 | 11 | - | 26627737 | HCT116 | viability after 6 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | 2.6862789239110176 | [263] | [270,264] | 9 | hSpCas9 | negative selection | 1768320 | 67428991 | 67429014 | 11 | - | 26627737 | HCT116 | viability after 6 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | -0.3932577897716179 | [849] | [171,62] | -2 | hSpCas9 | negative selection | 1768321 | 67429574 | 67429597 | 11 | + | 26627737 | HCT116 | viability after 6 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | 0.5764635473381945 | [566] | [81,160] | 3 | hSpCas9 | negative selection | 1768322 | 67428544 | 67428567 | 11 | - | 26627737 | HCT116 | viability after 8 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | 1.1629119951687448 | [126] | [131,210,126] | 8 | hSpCas9 | negative selection | 1850635 | 67428991 | 67429014 | 11 | - | 26627737 | HCT116 | viability after 8 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.635076909725139 | [271] | [215,166,313] | 6 | hSpCas9 | negative selection | 1850636 | 67429574 | 67429597 | 11 | + | 26627737 | HCT116 | viability after 8 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | -0.5835628869072114 | [382] | [106,182,131] | -6 | hSpCas9 | negative selection | 1850637 | 67428544 | 67428567 | 11 | - | 26627737 | HCT116 | viability after 9 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | 1.7643961330173419 | [263] | [520,16] | 9 | hSpCas9 | negative selection | 1932950 | 67428991 | 67429014 | 11 | - | 26627737 | HCT116 | viability after 9 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.09280253089099122 | [849] | [274,215] | 0 | hSpCas9 | negative selection | 1932951 | 67429574 | 67429597 | 11 | + | 26627737 | HCT116 | viability after 9 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | 0.48870629962674267 | [566] | [398,64] | 3 | hSpCas9 | negative selection | 1932952 | 67428544 | 67428567 | 11 | - | 26627737 | HCT116 | viability after 12 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | 0.94559222839488 | [126] | [173,60,144] | 7 | hSpCas9 | negative selection | 2015265 | 67428991 | 67429014 | 11 | - | 26627737 | HCT116 | viability after 12 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.9943552737074466 | [271] | [328,225,293] | 8 | hSpCas9 | negative selection | 2015266 | 67429574 | 67429597 | 11 | + | 26627737 | HCT116 | viability after 12 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | -0.7499602923470545 | [382] | [76,127,157] | -7 | hSpCas9 | negative selection | 2015267 | 67428544 | 67428567 | 11 | - | 26627737 | HCT116 | viability after 15 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | 1.244807984066818 | [126] | [165,119,230] | 8 | hSpCas9 | negative selection | 2097580 | 67428991 | 67429014 | 11 | - | 26627737 | HCT116 | viability after 15 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.6921099182413953 | [271] | [361,282,126] | 6 | hSpCas9 | negative selection | 2097581 | 67429574 | 67429597 | 11 | + | 26627737 | HCT116 | viability after 15 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | -0.7217984639171633 | [382] | [139,134,125] | -6 | hSpCas9 | negative selection | 2097582 | 67428544 | 67428567 | 11 | - | 26627737 | HCT116 | viability after 18 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | 1.1611167049792992 | [126] | [79,142,190] | 8 | hSpCas9 | negative selection | 2179895 | 67428991 | 67429014 | 11 | - | 26627737 | HCT116 | viability after 18 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.6133352761414841 | [271] | [195,198,208] | 5 | hSpCas9 | negative selection | 2179896 | 67429574 | 67429597 | 11 | + | 26627737 | HCT116 | viability after 18 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | -0.4860652193871223 | [382] | [20,182,191] | -4 | hSpCas9 | negative selection | 2179897 | 67428544 | 67428567 | 11 | - | 24336569 | HL60 | viability | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | 0.2765961437583343 | [622] | [1596] | 2 | hSpCas9 | negative selection | 2293028 | 67428551 | 67428574 | 11 | + | 24336569 | HL60 | viability | GGCCGTGTTTGATTTGGATTTGG | RPS6KB2 | ENSG00000175634 | 0.4784743764097833 | [251] | [742] | 4 | hSpCas9 | negative selection | 2293029 | 67428557 | 67428580 | 11 | + | 24336569 | HL60 | viability | GTTTGATTTGGATTTGGAGACGG | RPS6KB2 | ENSG00000175634 | 0.3666021990374181 | [474] | [1295] | 3 | hSpCas9 | negative selection | 2293030 | 67428564 | 67428587 | 11 | + | 24336569 | HL60 | viability | TTGGATTTGGAGACGGAGGAAGG | RPS6KB2 | ENSG00000175634 | 0.2743787519815769 | [823] | [2108] | 2 | hSpCas9 | negative selection | 2293031 | 67428572 | 67428595 | 11 | + | 24336569 | HL60 | viability | GGAGACGGAGGAAGGCAGCGAGG | RPS6KB2 | ENSG00000175634 | -1.0547841941140517 | [1767] | [1800] | -7 | hSpCas9 | negative selection | 2293032 | 67428578 | 67428601 | 11 | + | 24336569 | HL60 | viability | GGAGGAAGGCAGCGAGGGCGAGG | RPS6KB2 | ENSG00000175634 | 0.7204175796685411 | [414] | [1446] | 6 | hSpCas9 | negative selection | 2293033 | 67428992 | 67429015 | 11 | - | 24336569 | HL60 | viability | AGCTGCCCTCAACTCGGCAAGGG | RPS6KB2 | ENSG00000175634 | 1.3263570598507124 | [237] | [1262] | 8 | hSpCas9 | negative selection | 2293034 | 67428998 | 67429021 | 11 | - | 24336569 | HL60 | viability | TAGGCCAGCTGCCCTCAACTCGG | RPS6KB2 | ENSG00000175634 | 0.4864856682565948 | [1506] | [4467] | 4 | hSpCas9 | negative selection | 2293035 | 67429106 | 67429129 | 11 | + | 24336569 | HL60 | viability | CCTTGTGTCCGTAGGCCTGTGGG | RPS6KB2 | ENSG00000175634 | -0.30321632002855115 | [750] | [1287] | -3 | hSpCas9 | negative selection | 2293036 | 67429120 | 67429143 | 11 | + | 24336569 | HL60 | viability | GCCTGTGGGACACTATGAAGAGG | RPS6KB2 | ENSG00000175634 | -0.4734074290088566 | [722] | [1101] | -4 | hSpCas9 | negative selection | 2293037 | 67428544 | 67428567 | 11 | - | 24336569 | KBM7 | viability | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | -0.13018294917957318 | [828] | [2065] | -1 | hSpCas9 | negative selection | 2360205 | 67428551 | 67428574 | 11 | + | 24336569 | KBM7 | viability | GGCCGTGTTTGATTTGGATTTGG | RPS6KB2 | ENSG00000175634 | -0.4795220890516372 | [136] | [267] | -4 | hSpCas9 | negative selection | 2360206 | 67428557 | 67428580 | 11 | + | 24336569 | KBM7 | viability | GTTTGATTTGGATTTGGAGACGG | RPS6KB2 | ENSG00000175634 | 0.09260461995991318 | [468] | [1363] | 0 | hSpCas9 | negative selection | 2360207 | 67428564 | 67428587 | 11 | + | 24336569 | KBM7 | viability | TTGGATTTGGAGACGGAGGAAGG | RPS6KB2 | ENSG00000175634 | 0.5350360398376088 | [813] | [3216] | 5 | hSpCas9 | negative selection | 2360208 | 67428572 | 67428595 | 11 | + | 24336569 | KBM7 | viability | GGAGACGGAGGAAGGCAGCGAGG | RPS6KB2 | ENSG00000175634 | -3.312997094737266 | [1482] | [406] | -9 | hSpCas9 | negative selection | 2360209 | 67428578 | 67428601 | 11 | + | 24336569 | KBM7 | viability | GGAGGAAGGCAGCGAGGGCGAGG | RPS6KB2 | ENSG00000175634 | -1.2458620364940858 | [752] | [865] | -7 | hSpCas9 | negative selection | 2360210 | 67428992 | 67429015 | 11 | - | 24336569 | KBM7 | viability | AGCTGCCCTCAACTCGGCAAGGG | RPS6KB2 | ENSG00000175634 | -0.06038968222315533 | [254] | [666] | 0 | hSpCas9 | negative selection | 2360211 | 67428998 | 67429021 | 11 | - | 24336569 | KBM7 | viability | TAGGCCAGCTGCCCTCAACTCGG | RPS6KB2 | ENSG00000175634 | 0.36021824737944375 | [1396] | [4890] | 3 | hSpCas9 | negative selection | 2360212 | 67429106 | 67429129 | 11 | + | 24336569 | KBM7 | viability | CCTTGTGTCCGTAGGCCTGTGGG | RPS6KB2 | ENSG00000175634 | 1.4143092744772272 | [444] | [3234] | 9 | hSpCas9 | negative selection | 2360213 | 67429120 | 67429143 | 11 | + | 24336569 | KBM7 | viability | GCCTGTGGGACACTATGAAGAGG | RPS6KB2 | ENSG00000175634 | -0.5546929410341918 | [558] | [1037] | -4 | hSpCas9 | negative selection | 2360214 | 67428603 | 67428626 | 11 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | -0.5998487828251656 | [3,3] | [1,1] | -7 | hSpCas9 | positive selection | 3017996 | 67428553 | 67428576 | 11 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | CTCCAAATCCAAATCAAACACGG | RPS6KB2 | ENSG00000175634 | -0.1466862008509976 | [3,2] | [2,2] | -2 | hSpCas9 | positive selection | 3017997 | 67428603 | 67428626 | 11 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | -0.4828308947628258 | [3,3] | [2,0] | -7 | hSpCas9 | positive selection | 3085854 | 67428553 | 67428576 | 11 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | CTCCAAATCCAAATCAAACACGG | RPS6KB2 | ENSG00000175634 | 0.21340277314956746 | [3,3] | [3,2] | 4 | hSpCas9 | positive selection | 3085855 | 67429198 | 67429221 | | + | 24336571 | A375 | resistance to PLX after 7 days | CTTTGAGCTGCTGCGTGTGCTGG | RPS6KB2 | ENSG00000175634 | 0.32642807569415444 | [18,19] | [21,26] | 8 | hSpCas9 | positive selection | 3141912 | 67429198 | 67429221 | | + | 24336571 | A375 | resistance to PLX after 14 days | CTTTGAGCTGCTGCGTGTGCTGG | RPS6KB2 | ENSG00000175634 | 0.4928026436606918 | [17,24] | [15,11] | 4 | hSpCas9 | positive selection | 3199705 | 67429198 | 67429221 | | + | 24336571 | A375 | viability after 7 days | CTTTGAGCTGCTGCGTGTGCTGG | RPS6KB2 | ENSG00000175634 | 0.6353613231570894 | [12] | [18,19] | 8 | hSpCas9 | negative selection | 3257498 | 67429198 | 67429221 | | + | 24336571 | A375 | viability after 14 days | CTTTGAGCTGCTGCGTGTGCTGG | RPS6KB2 | ENSG00000175634 | 0.7848436839701575 | [12] | [17,24] | 8 | hSpCas9 | negative selection | 3315291 | 67429158 | 67429181 | 11 | - | 27383988 | 293T | resistance to West Nile virus (flavivirus) | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | 1.7337642553888224 | [45,45] | [0,0] | 7 | hSpCas9 | positive selection | 3390685 | 67428986 | 67429009 | 11 | + | 27383988 | 293T | resistance to West Nile virus (flavivirus) | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | -0.9025451253325543 | [285,285] | [0,0] | -6 | hSpCas9 | positive selection | 3390686 | 67428602 | 67428625 | 11 | + | 26780180 | HT29 | viability (Avana library 4 designs) | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | 2.13108702869093 | [] | [] | 7 | hSpCas9 | negative selection | 3456377 | 67428553 | 67428576 | 11 | - | 26780180 | HT29 | viability (Avana library 4 designs) | CTCCAAATCCAAATCAAACACGG | RPS6KB2 | ENSG00000175634 | -0.587692870201661 | [] | [] | -8 | hSpCas9 | negative selection | 3456378 | 67428602 | 67428625 | 11 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | 3.10137776217584 | [] | [] | 5 | hSpCas9 | negative selection | 3554826 | 67428553 | 67428576 | 11 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | CTCCAAATCCAAATCAAACACGG | RPS6KB2 | ENSG00000175634 | -6.01641575820211 | [] | [] | -6 | hSpCas9 | negative selection | 3554827 | 67428991 | 67429014 | 11 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 4.91387853608527 | [] | [] | 8 | hSpCas9 | negative selection | 3554828 | 67428602 | 67428625 | 11 | + | 26780180 | A375 | viability (Avana lentiGuide) | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | 7.86840787023558 | [] | [] | 6 | hSpCas9 | negative selection | 3663485 | 67428553 | 67428576 | 11 | - | 26780180 | A375 | viability (Avana lentiGuide) | CTCCAAATCCAAATCAAACACGG | RPS6KB2 | ENSG00000175634 | -3.17727388367404 | [] | [] | -5 | hSpCas9 | negative selection | 3663486 | 67428991 | 67429014 | 11 | - | 26780180 | A375 | viability (Avana lentiGuide) | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 5.58280371592592 | [] | [] | 5 | hSpCas9 | negative selection | 3663487 | 67428602 | 67428625 | 11 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | -0.21584902782507218 | [4] | [4,2] | -3 | hSpCas9 | positive selection | 3772092 | 67428553 | 67428576 | 11 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | CTCCAAATCCAAATCAAACACGG | RPS6KB2 | ENSG00000175634 | -1.1675065856604157 | [4] | [1,1] | -9 | hSpCas9 | positive selection | 3772093 | 67428991 | 67429014 | 11 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.41832269459284654 | [4] | [6,6] | 9 | hSpCas9 | positive selection | 3772094 | 67428602 | 67428625 | 11 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | -0.1825710667612762 | [5] | [4,2] | -3 | hSpCas9 | positive selection | 3880699 | 67428553 | 67428576 | 11 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | CTCCAAATCCAAATCAAACACGG | RPS6KB2 | ENSG00000175634 | 0.29542720140477374 | [4] | [4,4] | 8 | hSpCas9 | positive selection | 3880700 | 67428991 | 67429014 | 11 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | -0.11359183227572203 | [5] | [4,3] | -1 | hSpCas9 | positive selection | 3880701 | 67428986 | 67429009 | 11 | + | 26780180 | A375 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | 0.833924222281272 | [] | [] | 3 | hSpCas9 | negative selection | 3990725 | 67429158 | 67429181 | 11 | - | 26780180 | A375 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | 1.00625233641625 | [] | [] | 4 | hSpCas9 | negative selection | 3990726 | 67428986 | 67429009 | 11 | + | 26780180 | HT29 | viability (GeCKOv2 library) | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | 0.41247644642754 | [] | [] | 1 | hSpCas9 | negative selection | 4098691 | 67429158 | 67429181 | 11 | - | 26780180 | HT29 | viability (GeCKOv2 library) | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | 1.42132506104721 | [] | [] | 7 | hSpCas9 | negative selection | 4098692 | 67429198 | 67429221 | 11 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) | CTTTGAGCTGCTGCGTGTGCTGG | RPS6KB2 | ENSG00000175634 | 0.19093156223971047 | [3] | [2,3] | 5 | hSpCas9 | positive selection | 4167601 | 67429198 | 67429221 | 11 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiGuide) | CTTTGAGCTGCTGCGTGTGCTGG | RPS6KB2 | ENSG00000175634 | 1.1735437476843946 | [4] | [2,4,2,4] | 8 | hSpCas9 | positive selection | 4231623 | 67429158 | 67429181 | 11 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -0.5470767833147797 | [1] | [0,0] | -8 | hSpCas9 | positive selection | 4360063 | 67428986 | 67429009 | 11 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | 0.06643468295507565 | [3] | [3,2] | 1 | hSpCas9 | positive selection | 4360065 | 67429167 | 67429189 | 11 | + | 27760321 | OCIAML3 | viability | ACGTTGGCCCAGAGCGCATCGG | RPS6KB2 | ENSG00000175634 | -0.11627544773168774 | [830,697] | [522,583] | -1 | hSpCas9 | negative selection | 4435978 | 67429167 | 67429189 | 11 | + | 27760321 | OCIAML2 | viability | ACGTTGGCCCAGAGCGCATCGG | RPS6KB2 | ENSG00000175634 | -0.22941395669552023 | [830,697] | [411,674] | -3 | hSpCas9 | negative selection | 4519441 | 67429167 | 67429189 | 11 | + | 27760321 | MV411 | viability | ACGTTGGCCCAGAGCGCATCGG | RPS6KB2 | ENSG00000175634 | 0.4832328232647617 | [830,697] | [821,522] | 3 | hSpCas9 | negative selection | 4602904 | 67429167 | 67429189 | 11 | + | 27760321 | HL60 | viability | ACGTTGGCCCAGAGCGCATCGG | RPS6KB2 | ENSG00000175634 | -0.33773958916173275 | [830,697] | [483,500] | -4 | hSpCas9 | negative selection | 4686367 | 67429167 | 67429189 | 11 | + | 27760321 | HT1080 | viability | ACGTTGGCCCAGAGCGCATCGG | RPS6KB2 | ENSG00000175634 | -0.2979323716268451 | [697,544] | [135,272] | -1 | hSpCas9 | negative selection | 4769830 | 67429167 | 67429189 | 11 | + | 27760321 | HT29 | viability after 7 days | ACGTTGGCCCAGAGCGCATCGG | RPS6KB2 | ENSG00000175634 | -0.10762773663424496 | [697,544] | [896,733,618] | -1 | hSpCas9 | negative selection | 4853293 | 67429167 | 67429189 | 11 | + | 27760321 | HT29 | viability after 25 days | ACGTTGGCCCAGAGCGCATCGG | RPS6KB2 | ENSG00000175634 | -0.01690420720931407 | [697,544] | [880,688,502] | 0 | hSpCas9 | negative selection | 4936756 | 67429167 | 67429189 | 11 | + | 27760321 | HT29 | viability after 22 days | ACGTTGGCCCAGAGCGCATCGG | RPS6KB2 | ENSG00000175634 | 0.1388750525378324 | [697,544] | [703,842,828] | 1 | hSpCas9 | negative selection | 5020219 | 67429167 | 67429189 | 11 | + | 27760321 | HT29 | viability after 19 days | ACGTTGGCCCAGAGCGCATCGG | RPS6KB2 | ENSG00000175634 | -0.1325178969501969 | [697,544] | [553,652,724] | -1 | hSpCas9 | negative selection | 5103682 | 67429167 | 67429189 | 11 | + | 27760321 | HT29 | viability after 16 days | ACGTTGGCCCAGAGCGCATCGG | RPS6KB2 | ENSG00000175634 | -0.2527368164899769 | [697,544] | [727,406,633] | -3 | hSpCas9 | negative selection | 5187145 | 67429167 | 67429189 | 11 | + | 27760321 | HT29 | viability after 13 days | ACGTTGGCCCAGAGCGCATCGG | RPS6KB2 | ENSG00000175634 | -0.27532592725639704 | [697,544] | [530,535,712] | -3 | hSpCas9 | negative selection | 5270608 | 67429167 | 67429189 | 11 | + | 27760321 | HT29 | viability after 10 days | ACGTTGGCCCAGAGCGCATCGG | RPS6KB2 | ENSG00000175634 | 0.47499025989990873 | [697,544] | [832,1177,1223] | 6 | hSpCas9 | negative selection | 5354071 | 67429167 | 67429189 | 11 | + | 27760321 | MOLM13 | viability | ACGTTGGCCCAGAGCGCATCGG | RPS6KB2 | ENSG00000175634 | 0.6241056213362172 | [830,697] | [860,492] | 4 | hSpCas9 | negative selection | 5437534 | 67428495 | 67428518 | 11 | + | 27661255 | K562 | viability | GTCAGTGCGCGGCCAGGTACGGG | RPS6KB2 | ENSG00000175634 | 0.14037063121768908 | [651,796] | [654,618] | 5 | dCas9-KRAB | negative selection | 5508647 | 67428964 | 67428987 | 11 | - | 27661255 | K562 | viability | GCGTCCTGTGAGAAACCGAGGGG | RPS6KB2 | ENSG00000175634 | -0.14428768370930922 | [212,242] | [158,168] | -5 | dCas9-KRAB | negative selection | 5508648 | 67429158 | 67429181 | 11 | - | 27260156 | BXPC3 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -0.7275678653914375 | [140] | [43,69,67,191] | -9 | hSpCas9 | negative selection | 5632523 | 67428986 | 67429009 | 11 | + | 27260156 | BXPC3 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | 0.03211423425227877 | [725] | [551,768,963,851] | 0 | hSpCas9 | negative selection | 5632525 | 67429158 | 67429181 | 11 | - | 27260156 | A673 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -0.7583613230273578 | [140] | [108,114,105,68] | -9 | hSpCas9 | negative selection | 5753774 | 67428986 | 67429009 | 11 | + | 27260156 | A673 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | 0.13103820729829052 | [725] | [1017,834,980,994] | 3 | hSpCas9 | negative selection | 5753776 | 67429158 | 67429181 | 11 | - | 27260156 | A375 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -0.29033709101531024 | [140] | [133,155,133,118] | -4 | hSpCas9 | negative selection | 5875025 | 67428986 | 67429009 | 11 | + | 27260156 | A375 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | -0.14370340980793145 | [725] | [637,950,468,1004] | -2 | hSpCas9 | negative selection | 5875027 | 67429158 | 67429181 | 11 | - | 27260156 | COLO741 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -1.3984133605383693 | [140] | [48,109,45] | -9 | hSpCas9 | negative selection | 5996276 | 67428986 | 67429009 | 11 | + | 27260156 | COLO741 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | 0.016303009392860335 | [725] | [1040,954,832] | 0 | hSpCas9 | negative selection | 5996278 | 67429158 | 67429181 | 11 | - | 27260156 | CAL120 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -1.3012975976165573 | [140] | [59,87,63] | -9 | hSpCas9 | negative selection | 6117527 | 67428986 | 67429009 | 11 | + | 27260156 | CAL120 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | 0.16253400612391677 | [725] | [919,1068,1029] | 2 | hSpCas9 | negative selection | 6117529 | 67429158 | 67429181 | 11 | - | 27260156 | CADOES1 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -0.35294989621279327 | [140] | [65,108,51,186] | -6 | hSpCas9 | negative selection | 6238778 | 67428986 | 67429009 | 11 | + | 27260156 | CADOES1 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | 0.12938635108947472 | [725] | [739,714,817,678] | 2 | hSpCas9 | negative selection | 6238780 | 67429158 | 67429181 | 11 | - | 27260156 | EWS502 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -1.2538818545501302 | [140] | [53,24,87,87] | -9 | hSpCas9 | negative selection | 6360029 | 67428986 | 67429009 | 11 | + | 27260156 | EWS502 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | 0.21776812285685598 | [725] | [616,1031,881,1083] | 4 | hSpCas9 | negative selection | 6360031 | 67429158 | 67429181 | 11 | - | 27260156 | EW8 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -0.5988235555571053 | [140] | [154,35,52,69] | -8 | hSpCas9 | negative selection | 6481280 | 67428986 | 67429009 | 11 | + | 27260156 | EW8 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | 0.1579660157549987 | [725] | [796,639,473,758] | 3 | hSpCas9 | negative selection | 6481282 | 67429158 | 67429181 | 11 | - | 27260156 | CORL105 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -1.4871443817335324 | [140] | [26,85,90,34] | -9 | hSpCas9 | negative selection | 6602531 | 67428986 | 67429009 | 11 | + | 27260156 | CORL105 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | -0.04405863967185586 | [725] | [804,727,1043,755] | -1 | hSpCas9 | negative selection | 6602533 | 67429158 | 67429181 | 11 | - | 27260156 | HS294T | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -1.3854971373264513 | [140] | [17,16,26,21] | -9 | hSpCas9 | negative selection | 6723782 | 67428986 | 67429009 | 11 | + | 27260156 | HS294T | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | 0.19841221414613364 | [725] | [292,252,336,426] | 2 | hSpCas9 | negative selection | 6723784 | 67429158 | 67429181 | 11 | - | 27260156 | HCC44 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -1.0259869061012326 | [140] | [83,49,136,56] | -8 | hSpCas9 | negative selection | 6845033 | 67428986 | 67429009 | 11 | + | 27260156 | HCC44 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | -0.024728217333421676 | [725] | [809,526,1207,786] | 0 | hSpCas9 | negative selection | 6845035 | 67429158 | 67429181 | 11 | - | 27260156 | G402 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -0.8356253432665468 | [140] | [176,143,31,48] | -7 | hSpCas9 | negative selection | 6966284 | 67428986 | 67429009 | 11 | + | 27260156 | G402 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | 0.05447124228056688 | [725] | [927,962,637,1139] | 0 | hSpCas9 | negative selection | 6966286 | 67429158 | 67429181 | 11 | - | 27260156 | L33 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -1.1076939595279585 | [140] | [70,31,46,37] | -9 | hSpCas9 | negative selection | 7087535 | 67428986 | 67429009 | 11 | + | 27260156 | L33 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | 0.22353956528607066 | [725] | [973,348,495,772] | 5 | hSpCas9 | negative selection | 7087537 | 67429158 | 67429181 | 11 | - | 27260156 | K562 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -0.8629240068116026 | [140] | [31,60,123,55] | -7 | hSpCas9 | negative selection | 7208786 | 67428986 | 67429009 | 11 | + | 27260156 | K562 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | 0.4687081527174961 | [725] | [982,1333,834,488] | 6 | hSpCas9 | negative selection | 7208788 | 67429158 | 67429181 | 11 | - | 27260156 | HT29 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -0.9330004066045332 | [140] | [48,103,108,93] | -8 | hSpCas9 | negative selection | 7330037 | 67428986 | 67429009 | 11 | + | 27260156 | HT29 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | 0.19981453644318836 | [725] | [914,1013,1001,1097] | 4 | hSpCas9 | negative selection | 7330039 | 67429158 | 67429181 | 11 | - | 27260156 | MHHES1 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -0.6341330926101814 | [140] | [99,152,63,95] | -8 | hSpCas9 | negative selection | 7451288 | 67428986 | 67429009 | 11 | + | 27260156 | MHHES1 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | -0.11572524184634492 | [725] | [748,665,585,943] | -2 | hSpCas9 | negative selection | 7451290 | 67429158 | 67429181 | 11 | - | 27260156 | MEWO | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -0.4293365858014655 | [140] | [169,59,77] | -7 | hSpCas9 | negative selection | 7572539 | 67428986 | 67429009 | 11 | + | 27260156 | MEWO | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | 0.20432677948601563 | [725] | [876,741,746] | 4 | hSpCas9 | negative selection | 7572541 | 67429158 | 67429181 | 11 | - | 27260156 | LNCAPCLONEFGC | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | 0.5309484057315954 | [140] | [41,98,625,44] | 8 | hSpCas9 | negative selection | 7693790 | 67428986 | 67429009 | 11 | + | 27260156 | LNCAPCLONEFGC | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | -0.09565068009277922 | [725] | [652,556,705,561] | -1 | hSpCas9 | negative selection | 7693792 | 67429158 | 67429181 | 11 | - | 27260156 | PANC0327 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | 0.05840800521533729 | [140] | [148,224,103,32] | 0 | hSpCas9 | negative selection | 7815041 | 67428986 | 67429009 | 11 | + | 27260156 | PANC0327 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | -0.17461040370796982 | [725] | [601,413,511,779] | -3 | hSpCas9 | negative selection | 7815043 | 67429158 | 67429181 | 11 | - | 27260156 | NCIH2009 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -0.5457954776620728 | [140] | [105,183,107] | -6 | hSpCas9 | negative selection | 7936292 | 67428986 | 67429009 | 11 | + | 27260156 | NCIH2009 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | 0.23146814105947577 | [725] | [1423,1170,1021] | 3 | hSpCas9 | negative selection | 7936294 | 67429158 | 67429181 | 11 | - | 27260156 | NCIH1373 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -0.3343569823802637 | [140] | [88,53,245,28] | -3 | hSpCas9 | negative selection | 8057543 | 67428986 | 67429009 | 11 | + | 27260156 | NCIH1373 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | -0.3310439926664635 | [725] | [723,711,452,185] | -3 | hSpCas9 | negative selection | 8057545 | 67429158 | 67429181 | 11 | - | 27260156 | PATU8902 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -1.3473171059269997 | [140] | [166,47,5,107] | -8 | hSpCas9 | negative selection | 8178794 | 67428986 | 67429009 | 11 | + | 27260156 | PATU8902 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | -0.8597930587402842 | [725] | [627,453,585,545] | -7 | hSpCas9 | negative selection | 8178796 | 67429158 | 67429181 | 11 | - | 27260156 | PANC1 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -1.3443490403248 | [140] | [19,45,66,55] | -9 | hSpCas9 | negative selection | 8300045 | 67428986 | 67429009 | 11 | + | 27260156 | PANC1 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | 0.4078337441444648 | [725] | [694,921,860,837] | 6 | hSpCas9 | negative selection | 8300047 | 67429158 | 67429181 | 11 | - | 27260156 | PANC0813 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -0.6369030675325325 | [140] | [102,168,42,109] | -7 | hSpCas9 | negative selection | 8421296 | 67428986 | 67429009 | 11 | + | 27260156 | PANC0813 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | 0.14703762666885478 | [725] | [1136,788,761,1095] | 2 | hSpCas9 | negative selection | 8421298 | 67429158 | 67429181 | 11 | - | 27260156 | RDES | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -1.0830524435113296 | [140] | [61,47,115,86] | -9 | hSpCas9 | negative selection | 8542547 | 67428986 | 67429009 | 11 | + | 27260156 | RDES | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | -0.3375436800674038 | [725] | [572,573,781,736] | -5 | hSpCas9 | negative selection | 8542549 | 67429158 | 67429181 | 11 | - | 27260156 | PC3 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -0.7106718763338942 | [140] | [54,118,131,56] | -9 | hSpCas9 | negative selection | 8663798 | 67428986 | 67429009 | 11 | + | 27260156 | PC3 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | -0.019371081401553192 | [725] | [518,709,976,759] | 0 | hSpCas9 | negative selection | 8663800 | 67429158 | 67429181 | 11 | - | 27260156 | PATU8988T | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -0.40941464227011815 | [140] | [142,80,77,106] | -6 | hSpCas9 | negative selection | 8785049 | 67428986 | 67429009 | 11 | + | 27260156 | PATU8988T | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | -0.008402056524345336 | [725] | [774,675,644,691] | 0 | hSpCas9 | negative selection | 8785051 | 67429158 | 67429181 | 11 | - | 27260156 | T47D | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -0.7010144022179217 | [140] | [120,75,93,115] | -8 | hSpCas9 | negative selection | 8906300 | 67428986 | 67429009 | 11 | + | 27260156 | T47D | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | -0.015669203186025493 | [725] | [901,645,914,900] | 0 | hSpCas9 | negative selection | 8906302 | 67429158 | 67429181 | 11 | - | 27260156 | SU8686 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -2.073216486010577 | [140] | [38,11,39,45] | -9 | hSpCas9 | negative selection | 9027551 | 67428986 | 67429009 | 11 | + | 27260156 | SU8686 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | 0.11254328545774861 | [725] | [745,690,938,744] | 2 | hSpCas9 | negative selection | 9027553 | 67429158 | 67429181 | 11 | - | 27260156 | SKES1 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -0.6462586973383904 | [140] | [83,160,62,61] | -8 | hSpCas9 | negative selection | 9148802 | 67428986 | 67429009 | 11 | + | 27260156 | SKES1 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | 0.14665426436489504 | [725] | [1137,774,599,738] | 3 | hSpCas9 | negative selection | 9148804 | 67429158 | 67429181 | 11 | - | 27260156 | TOV112D | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -1.129853138727438 | [140] | [58,102,75,29] | -9 | hSpCas9 | negative selection | 9270053 | 67428986 | 67429009 | 11 | + | 27260156 | TOV112D | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | -0.028918148239768682 | [725] | [737,643,818,635] | 0 | hSpCas9 | negative selection | 9270055 | 67429158 | 67429181 | 11 | - | 27260156 | TC71 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -0.9980316985903277 | [140] | [18,69,76,141] | -9 | hSpCas9 | negative selection | 9391304 | 67428986 | 67429009 | 11 | + | 27260156 | TC71 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | 0.09255664355493443 | [725] | [846,880,781,808] | 2 | hSpCas9 | negative selection | 9391306 | 67429158 | 67429181 | 11 | - | 27260156 | TC32 | viability | CTCTGGGCCAACGTTCACGCTGG | RPS6KB2 | ENSG00000175634 | -0.7615448486485497 | [140] | [90,30,98,108] | -9 | hSpCas9 | negative selection | 9512555 | 67428986 | 67429009 | 11 | + | 27260156 | TC32 | viability | CATGTCCCCTTGCCGAGTTGAGG | RPS6KB2 | ENSG00000175634 | -0.05809667268540375 | [725] | [552,445,1029,715] | -1 | hSpCas9 | negative selection | 9512557 | 67428544 | 67428567 | 11 | - | 27869803 | HPAFII | viability after 27 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | -0.4404069030642272 | [297] | [175,64,NaN] | -3 | hSpCas9 | negative selection | 9543540 | 67428991 | 67429014 | 11 | - | 27869803 | HPAFII | viability after 27 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.1254573227244452 | [268] | [204,111,NaN] | 1 | hSpCas9 | negative selection | 9543541 | 67429574 | 67429597 | 11 | + | 27869803 | HPAFII | viability after 27 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | 0.22155131971528605 | [287] | [25,301,NaN] | 1 | hSpCas9 | negative selection | 9543542 | 67428544 | 67428567 | 11 | - | 27869803 | HPAFII | viability after 15 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | -0.5008788347194304 | [297] | [332,159,NaN] | -5 | hSpCas9 | negative selection | 9625989 | 67428991 | 67429014 | 11 | - | 27869803 | HPAFII | viability after 15 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.16866317665183211 | [268] | [385,286,NaN] | 2 | hSpCas9 | negative selection | 9625990 | 67429574 | 67429597 | 11 | + | 27869803 | HPAFII | viability after 15 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | -0.133335946355789 | [287] | [259,295,NaN] | -1 | hSpCas9 | negative selection | 9625991 | 67428544 | 67428567 | 11 | - | 27869803 | ASPC1 | viability after 36 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | -0.6638388255508554 | [541] | [68,41,214] | -6 | hSpCas9 | negative selection | 9708438 | 67428991 | 67429014 | 11 | - | 27869803 | ASPC1 | viability after 36 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.1323786436207514 | [662] | [81,417,240] | 1 | hSpCas9 | negative selection | 9708439 | 67429574 | 67429597 | 11 | + | 27869803 | ASPC1 | viability after 36 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | -0.17938757557400203 | [678] | [304,270,90] | -2 | hSpCas9 | negative selection | 9708440 | 67428544 | 67428567 | 11 | - | 27869803 | PATU8988S | viability after 35 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | -0.354545054477554 | [626] | [198,195,NaN] | -4 | hSpCas9 | negative selection | 9790887 | 67428991 | 67429014 | 11 | - | 27869803 | PATU8988S | viability after 35 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.547720551142048 | [598] | [417,286,NaN] | 6 | hSpCas9 | negative selection | 9790888 | 67429574 | 67429597 | 11 | + | 27869803 | PATU8988S | viability after 35 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | -0.023217771625731756 | [587] | [248,216,NaN] | 0 | hSpCas9 | negative selection | 9790889 | 67428544 | 67428567 | 11 | - | 27869803 | PATU8988S | viability after 31 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | -0.2026759561275868 | [626] | [240,186,NaN] | -2 | hSpCas9 | negative selection | 9873336 | 67428991 | 67429014 | 11 | - | 27869803 | PATU8988S | viability after 31 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.24611129707866775 | [598] | [255,317,NaN] | 3 | hSpCas9 | negative selection | 9873337 | 67429574 | 67429597 | 11 | + | 27869803 | PATU8988S | viability after 31 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | -0.2426264001785949 | [587] | [235,149,NaN] | -3 | hSpCas9 | negative selection | 9873338 | 67428544 | 67428567 | 11 | - | 27869803 | HPAFII | viability after 35 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | -1.210419849925687 | [297] | [99,25,NaN] | -6 | hSpCas9 | negative selection | 9955785 | 67428991 | 67429014 | 11 | - | 27869803 | HPAFII | viability after 35 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.6278826642439446 | [268] | [264,148,NaN] | 4 | hSpCas9 | negative selection | 9955786 | 67429574 | 67429597 | 11 | + | 27869803 | HPAFII | viability after 35 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | 0.6688904675157721 | [287] | [61,422,NaN] | 4 | hSpCas9 | negative selection | 9955787 | 67428544 | 67428567 | 11 | - | 27869803 | HPAFII | viability after 31 days | CAAATCAAACACGGCCGCCATGG | RPS6KB2 | ENSG00000175634 | -1.6563222377964495 | [297] | [98,2,NaN] | -7 | hSpCas9 | negative selection | 10038234 | 67428991 | 67429014 | 11 | - | 27869803 | HPAFII | viability after 31 days | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.20591797012591107 | [268] | [176,170,NaN] | 1 | hSpCas9 | negative selection | 10038235 | 67429574 | 67429597 | 11 | + | 27869803 | HPAFII | viability after 31 days | TGCCATGAAAGTCCTAAGGAAGG | RPS6KB2 | ENSG00000175634 | 0.6503040461584071 | [287] | [78,443,NaN] | 5 | hSpCas9 | negative selection | 10038236 | 67429123 | 67429146 | 11 | + | 28162770 | P31FUJ | viability | TGTGGGACACTATGAAGAGGTGG | RPS6KB2 | ENSG00000175634 | 0.6467919456796298 | [280] | [516] | 7 | hSpCas9 | negative selection | 10228139 | 67428991 | 67429014 | 11 | - | 28162770 | P31FUJ | viability | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | -0.49266933116948947 | [181] | [151] | -4 | hSpCas9 | negative selection | 10228140 | 67428573 | 67428596 | 11 | + | 28162770 | P31FUJ | viability | GAGACGGAGGAAGGCAGCGAGGG | RPS6KB2 | ENSG00000175634 | -0.4522473417004895 | [162] | [139] | -4 | hSpCas9 | negative selection | 10228141 | 67428560 | 67428583 | 11 | + | 28162770 | P31FUJ | viability | TGATTTGGATTTGGAGACGGAGG | RPS6KB2 | ENSG00000175634 | 0.35673302609660174 | [104] | [157] | 4 | hSpCas9 | negative selection | 10228142 | 67428602 | 67428625 | 11 | + | 28162770 | P31FUJ | viability | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | -0.47555233879381753 | [225] | [190] | -4 | hSpCas9 | negative selection | 10228143 | 67429123 | 67429146 | 11 | + | 28162770 | TF1 | viability | TGTGGGACACTATGAAGAGGTGG | RPS6KB2 | ENSG00000175634 | NaN | [NaN] | [315] | 1 | hSpCas9 | negative selection | 10397505 | 67428991 | 67429014 | 11 | - | 28162770 | TF1 | viability | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | NaN | [NaN] | [314] | 1 | hSpCas9 | negative selection | 10397506 | 67428573 | 67428596 | 11 | + | 28162770 | TF1 | viability | GAGACGGAGGAAGGCAGCGAGGG | RPS6KB2 | ENSG00000175634 | NaN | [NaN] | [128] | 1 | hSpCas9 | negative selection | 10397507 | 67428560 | 67428583 | 11 | + | 28162770 | TF1 | viability | TGATTTGGATTTGGAGACGGAGG | RPS6KB2 | ENSG00000175634 | NaN | [NaN] | [100] | 1 | hSpCas9 | negative selection | 10397508 | 67428602 | 67428625 | 11 | + | 28162770 | TF1 | viability | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | NaN | [NaN] | [149] | 1 | hSpCas9 | negative selection | 10397509 | 67429123 | 67429146 | 11 | + | 28162770 | SKM1 | viability | TGTGGGACACTATGAAGAGGTGG | RPS6KB2 | ENSG00000175634 | -0.808581182259684 | [106] | [107] | -6 | hSpCas9 | negative selection | 10566871 | 67428991 | 67429014 | 11 | - | 28162770 | SKM1 | viability | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.7502497509495967 | [37] | [112] | 7 | hSpCas9 | negative selection | 10566872 | 67428573 | 67428596 | 11 | + | 28162770 | SKM1 | viability | GAGACGGAGGAAGGCAGCGAGGG | RPS6KB2 | ENSG00000175634 | -0.7950346504217363 | [52] | [53] | -5 | hSpCas9 | negative selection | 10566873 | 67428560 | 67428583 | 11 | + | 28162770 | SKM1 | viability | TGATTTGGATTTGGAGACGGAGG | RPS6KB2 | ENSG00000175634 | 0.677569311468506 | [28] | [81] | 6 | hSpCas9 | negative selection | 10566874 | 67428602 | 67428625 | 11 | + | 28162770 | SKM1 | viability | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | -0.5224414161630976 | [38] | [47] | -4 | hSpCas9 | negative selection | 10566875 | 67429123 | 67429146 | 11 | + | 28162770 | SKM1 | viability | TGTGGGACACTATGAAGAGGTGG | RPS6KB2 | ENSG00000175634 | -0.808581182259684 | [106] | [107] | -6 | hSpCas9 | negative selection | 10736237 | 67428991 | 67429014 | 11 | - | 28162770 | SKM1 | viability | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.7502497509495967 | [37] | [112] | 7 | hSpCas9 | negative selection | 10736238 | 67428573 | 67428596 | 11 | + | 28162770 | SKM1 | viability | GAGACGGAGGAAGGCAGCGAGGG | RPS6KB2 | ENSG00000175634 | -0.7950346504217363 | [52] | [53] | -5 | hSpCas9 | negative selection | 10736239 | 67428560 | 67428583 | 11 | + | 28162770 | SKM1 | viability | TGATTTGGATTTGGAGACGGAGG | RPS6KB2 | ENSG00000175634 | 0.677569311468506 | [28] | [81] | 6 | hSpCas9 | negative selection | 10736240 | 67428602 | 67428625 | 11 | + | 28162770 | SKM1 | viability | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | -0.5224414161630976 | [38] | [47] | -4 | hSpCas9 | negative selection | 10736241 | 67429123 | 67429146 | 11 | + | 28162770 | PL21 | viability | TGTGGGACACTATGAAGAGGTGG | RPS6KB2 | ENSG00000175634 | -0.017337316433011285 | [292] | [125] | 0 | hSpCas9 | negative selection | 10905603 | 67428991 | 67429014 | 11 | - | 28162770 | PL21 | viability | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.2309456612704947 | [138] | [70] | 2 | hSpCas9 | negative selection | 10905604 | 67428573 | 67428596 | 11 | + | 28162770 | PL21 | viability | GAGACGGAGGAAGGCAGCGAGGG | RPS6KB2 | ENSG00000175634 | -0.8482234070720788 | [272] | [65] | -5 | hSpCas9 | negative selection | 10905605 | 67428560 | 67428583 | 11 | + | 28162770 | PL21 | viability | TGATTTGGATTTGGAGACGGAGG | RPS6KB2 | ENSG00000175634 | -1.2420827141157538 | [124] | [22] | -7 | hSpCas9 | negative selection | 10905606 | 67428602 | 67428625 | 11 | + | 28162770 | PL21 | viability | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | 1.5189617985088608 | [92] | [115] | 9 | hSpCas9 | negative selection | 10905607 | 67429123 | 67429146 | 11 | + | 28162770 | P31FUJ | viability | TGTGGGACACTATGAAGAGGTGG | RPS6KB2 | ENSG00000175634 | 0.6467919456796298 | [280] | [516] | 7 | hSpCas9 | negative selection | 11074969 | 67428991 | 67429014 | 11 | - | 28162770 | P31FUJ | viability | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | -0.49266933116948947 | [181] | [151] | -4 | hSpCas9 | negative selection | 11074970 | 67428573 | 67428596 | 11 | + | 28162770 | P31FUJ | viability | GAGACGGAGGAAGGCAGCGAGGG | RPS6KB2 | ENSG00000175634 | -0.4522473417004895 | [162] | [139] | -4 | hSpCas9 | negative selection | 11074971 | 67428560 | 67428583 | 11 | + | 28162770 | P31FUJ | viability | TGATTTGGATTTGGAGACGGAGG | RPS6KB2 | ENSG00000175634 | 0.35673302609660174 | [104] | [157] | 4 | hSpCas9 | negative selection | 11074972 | 67428602 | 67428625 | 11 | + | 28162770 | P31FUJ | viability | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | -0.47555233879381753 | [225] | [190] | -4 | hSpCas9 | negative selection | 11074973 | 67429123 | 67429146 | 11 | + | 28162770 | OCIAML5 | viability | TGTGGGACACTATGAAGAGGTGG | RPS6KB2 | ENSG00000175634 | 0.05548718037140793 | [144] | [271] | 0 | hSpCas9 | negative selection | 11244335 | 67428991 | 67429014 | 11 | - | 28162770 | OCIAML5 | viability | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | -0.3345319976631316 | [145] | [208] | -2 | hSpCas9 | negative selection | 11244336 | 67428573 | 67428596 | 11 | + | 28162770 | OCIAML5 | viability | GAGACGGAGGAAGGCAGCGAGGG | RPS6KB2 | ENSG00000175634 | -0.43323749242277904 | [94] | [126] | -3 | hSpCas9 | negative selection | 11244337 | 67428560 | 67428583 | 11 | + | 28162770 | OCIAML5 | viability | TGATTTGGATTTGGAGACGGAGG | RPS6KB2 | ENSG00000175634 | -0.524012373179793 | [46] | [58] | -4 | hSpCas9 | negative selection | 11244338 | 67428602 | 67428625 | 11 | + | 28162770 | OCIAML5 | viability | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | 0.6255123944835598 | [78] | [219] | 5 | hSpCas9 | negative selection | 11244339 | 67429123 | 67429146 | 11 | + | 28162770 | EOL1 | viability | TGTGGGACACTATGAAGAGGTGG | RPS6KB2 | ENSG00000175634 | -0.3188296748952494 | [553] | [233] | -2 | hSpCas9 | negative selection | 11413701 | 67428991 | 67429014 | 11 | - | 28162770 | EOL1 | viability | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | -0.2341499744485237 | [191] | [85] | -2 | hSpCas9 | negative selection | 11413702 | 67428573 | 67428596 | 11 | + | 28162770 | EOL1 | viability | GAGACGGAGGAAGGCAGCGAGGG | RPS6KB2 | ENSG00000175634 | -1.1321666194237867 | [440] | [105] | -6 | hSpCas9 | negative selection | 11413703 | 67428560 | 67428583 | 11 | + | 28162770 | EOL1 | viability | TGATTTGGATTTGGAGACGGAGG | RPS6KB2 | ENSG00000175634 | 0.39552344244323584 | [214] | [148] | 3 | hSpCas9 | negative selection | 11413704 | 67428602 | 67428625 | 11 | + | 28162770 | EOL1 | viability | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | 0.2046556907632699 | [195] | [118] | 1 | hSpCas9 | negative selection | 11413705 | 67429123 | 67429146 | 11 | + | 28162770 | MOLM13 | viability | TGTGGGACACTATGAAGAGGTGG | RPS6KB2 | ENSG00000175634 | -0.15237998791253016 | [454] | [295] | -1 | hSpCas9 | negative selection | 11583067 | 67428991 | 67429014 | 11 | - | 28162770 | MOLM13 | viability | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.33131632866913496 | [154] | [140] | 2 | hSpCas9 | negative selection | 11583068 | 67428573 | 67428596 | 11 | + | 28162770 | MOLM13 | viability | GAGACGGAGGAAGGCAGCGAGGG | RPS6KB2 | ENSG00000175634 | -0.9915422370927185 | [362] | [131] | -5 | hSpCas9 | negative selection | 11583069 | 67428560 | 67428583 | 11 | + | 28162770 | MOLM13 | viability | TGATTTGGATTTGGAGACGGAGG | RPS6KB2 | ENSG00000175634 | 0.07435295147665705 | [221] | [168] | 0 | hSpCas9 | negative selection | 11583070 | 67428602 | 67428625 | 11 | + | 28162770 | MOLM13 | viability | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | -0.5413291484848 | [156] | [77] | -3 | hSpCas9 | negative selection | 11583071 | 67429123 | 67429146 | 11 | + | 28162770 | HEL | viability | TGTGGGACACTATGAAGAGGTGG | RPS6KB2 | ENSG00000175634 | -0.4715183472573231 | [393] | [181] | -3 | hSpCas9 | negative selection | 11752433 | 67428991 | 67429014 | 11 | - | 28162770 | HEL | viability | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 0.450093754057961 | [175] | [153] | 4 | hSpCas9 | negative selection | 11752434 | 67428573 | 67428596 | 11 | + | 28162770 | HEL | viability | GAGACGGAGGAAGGCAGCGAGGG | RPS6KB2 | ENSG00000175634 | -0.5458018476093023 | [350] | [153] | -4 | hSpCas9 | negative selection | 11752435 | 67428560 | 67428583 | 11 | + | 28162770 | HEL | viability | TGATTTGGATTTGGAGACGGAGG | RPS6KB2 | ENSG00000175634 | -0.06508041650633256 | [146] | [89] | 0 | hSpCas9 | negative selection | 11752436 | 67428602 | 67428625 | 11 | + | 28162770 | HEL | viability | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | -0.06027943024251148 | [139] | [85] | 0 | hSpCas9 | negative selection | 11752437 | 67429123 | 67429146 | 11 | + | 28162770 | MV411 | viability | TGTGGGACACTATGAAGAGGTGG | RPS6KB2 | ENSG00000175634 | 0.4753894974611239 | [221] | [259] | 4 | hSpCas9 | negative selection | 11921799 | 67428991 | 67429014 | 11 | - | 28162770 | MV411 | viability | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | -0.2733946125186653 | [131] | [91] | -2 | hSpCas9 | negative selection | 11921800 | 67428573 | 67428596 | 11 | + | 28162770 | MV411 | viability | GAGACGGAGGAAGGCAGCGAGGG | RPS6KB2 | ENSG00000175634 | -1.4612603183606259 | [218] | [66] | -7 | hSpCas9 | negative selection | 11921801 | 67428560 | 67428583 | 11 | + | 28162770 | MV411 | viability | TGATTTGGATTTGGAGACGGAGG | RPS6KB2 | ENSG00000175634 | -0.26381526375537157 | [123] | [86] | -2 | hSpCas9 | negative selection | 11921802 | 67428602 | 67428625 | 11 | + | 28162770 | MV411 | viability | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | -0.1048641931481058 | [119] | [93] | -1 | hSpCas9 | negative selection | 11921803 | 67429123 | 67429146 | 11 | + | 28162770 | MONOMAC1 | viability | TGTGGGACACTATGAAGAGGTGG | RPS6KB2 | ENSG00000175634 | 0.7894588885906988 | [160] | [318] | 7 | hSpCas9 | negative selection | 12091165 | 67428991 | 67429014 | 11 | - | 28162770 | MONOMAC1 | viability | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 2.1857368030483357 | [64] | [338] | 9 | hSpCas9 | negative selection | 12091166 | 67428573 | 67428596 | 11 | + | 28162770 | MONOMAC1 | viability | GAGACGGAGGAAGGCAGCGAGGG | RPS6KB2 | ENSG00000175634 | 0.3963378934778025 | [113] | [171] | 4 | hSpCas9 | negative selection | 12091167 | 67428560 | 67428583 | 11 | + | 28162770 | MONOMAC1 | viability | TGATTTGGATTTGGAGACGGAGG | RPS6KB2 | ENSG00000175634 | 0.8447833286350732 | [84] | [174] | 7 | hSpCas9 | negative selection | 12091168 | 67428602 | 67428625 | 11 | + | 28162770 | MONOMAC1 | viability | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | 0.5965122754730199 | [74] | [129] | 6 | hSpCas9 | negative selection | 12091169 | 67429123 | 67429146 | 11 | + | 28162770 | OCIAML2 | viability | TGTGGGACACTATGAAGAGGTGG | RPS6KB2 | ENSG00000175634 | -0.45974150909942496 | [65] | [265] | -4 | hSpCas9 | negative selection | 12260531 | 67428991 | 67429014 | 11 | - | 28162770 | OCIAML2 | viability | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | 1.0566171776227076 | [16] | [195] | 8 | hSpCas9 | negative selection | 12260532 | 67428573 | 67428596 | 11 | + | 28162770 | OCIAML2 | viability | GAGACGGAGGAAGGCAGCGAGGG | RPS6KB2 | ENSG00000175634 | -0.7882015150853876 | [61] | [198] | -5 | hSpCas9 | negative selection | 12260533 | 67428560 | 67428583 | 11 | + | 28162770 | OCIAML2 | viability | TGATTTGGATTTGGAGACGGAGG | RPS6KB2 | ENSG00000175634 | -0.04916605680388447 | [27] | [149] | 0 | hSpCas9 | negative selection | 12260534 | 67428602 | 67428625 | 11 | + | 28162770 | OCIAML2 | viability | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | -0.07831240246340088 | [23] | [125] | 0 | hSpCas9 | negative selection | 12260535 | 67429123 | 67429146 | 11 | + | 28162770 | OCIAML3 | viability | TGTGGGACACTATGAAGAGGTGG | RPS6KB2 | ENSG00000175634 | 0.23817256076801185 | [106] | [380] | 2 | hSpCas9 | negative selection | 12429897 | 67428991 | 67429014 | 11 | - | 28162770 | OCIAML3 | viability | GCTGCCCTCAACTCGGCAAGGGG | RPS6KB2 | ENSG00000175634 | -0.2633623283356916 | [32] | [82] | -2 | hSpCas9 | negative selection | 12429898 | 67428573 | 67428596 | 11 | + | 28162770 | OCIAML3 | viability | GAGACGGAGGAAGGCAGCGAGGG | RPS6KB2 | ENSG00000175634 | -0.6225767925209341 | [50] | [99] | -5 | hSpCas9 | negative selection | 12429899 | 67428560 | 67428583 | 11 | + | 28162770 | OCIAML3 | viability | TGATTTGGATTTGGAGACGGAGG | RPS6KB2 | ENSG00000175634 | -0.3309732344903695 | [39] | [95] | -3 | hSpCas9 | negative selection | 12429900 | 67428602 | 67428625 | 11 | + | 28162770 | OCIAML3 | viability | CGAGCCAGAGCTCAGCCCCGCGG | RPS6KB2 | ENSG00000175634 | -1.009045139603007 | [29] | [44] | -6 | hSpCas9 | negative selection | 12429901 |