Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:50944
• Symbol:SHANK1
• Description:SH3 and multiple ankyrin repeat domains 1

DataSource: http://genomecrispr.dkfz.de/#!/results/SHANK1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
50716743	50716766	19	+	26472758	Jiyoye	viability	GCCCTGGAGGCCTCTAACAGAGG	SHANK1	ENSG00000161681	-0.2794585371101884	[168]	[104]	-2	hSpCas9	negative selection	146335
50669174	50669197	19	+	26472758	Jiyoye	viability	GGTGGGGACGTGGTGGGTGGCGG	SHANK1	ENSG00000161681	-0.43412687247506826	[128]	[71]	-3	hSpCas9	negative selection	146336
50716341	50716364	19	+	26472758	Jiyoye	viability	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	0.610267246883385	[85]	[98]	4	hSpCas9	negative selection	146337
50713916	50713939	19	-	26472758	Jiyoye	viability	ACACTGGCGGCCCAGACCGAAGG	SHANK1	ENSG00000161681	0.5845716323793212	[213]	[241]	4	hSpCas9	negative selection	146338
50711460	50711483	19	+	26472758	Jiyoye	viability	GGTGCTGAGAGTGACCCCGCTGG	SHANK1	ENSG00000161681	-0.38132051330041516	[18]	[10]	-3	hSpCas9	negative selection	146339
50702503	50702526	19	-	26472758	Jiyoye	viability	GTCCTACCAGGCCCAAGCCGAGG	SHANK1	ENSG00000161681	1.5161097530590373	[50]	[109]	8	hSpCas9	negative selection	146340
50702481	50702504	19	-	26472758	Jiyoye	viability	GGGGAGATCTCCCTGAGCAAGGG	SHANK1	ENSG00000161681	0.7291034763932358	[55]	[69]	5	hSpCas9	negative selection	146341
50688034	50688057	19	-	26472758	Jiyoye	viability	GAACGGGCAGAATGTGGTGAAGG	SHANK1	ENSG00000161681	-0.6037129346368628	[132]	[65]	-4	hSpCas9	negative selection	146342
50688016	50688039	19	-	26472758	Jiyoye	viability	GAAGGTCGGCCACCGACAGGTGG	SHANK1	ENSG00000161681	0.06322098028851209	[197]	[155]	0	hSpCas9	negative selection	146343
50687997	50688020	19	-	26472758	Jiyoye	viability	GTGGTGAACATGATCCGCCAAGG	SHANK1	ENSG00000161681	0.582542468016434	[146]	[165]	4	hSpCas9	negative selection	146344
50716743	50716766	19	+	26472758	KBM7	viability	GCCCTGGAGGCCTCTAACAGAGG	SHANK1	ENSG00000161681	0.14279530367024829	[555,316]	[261,184]	1	hSpCas9	negative selection	337453
50669174	50669197	19	+	26472758	KBM7	viability	GGTGGGGACGTGGTGGGTGGCGG	SHANK1	ENSG00000161681	-0.9655846518618312	[378,356]	[130,50]	-6	hSpCas9	negative selection	337454
50716341	50716364	19	+	26472758	KBM7	viability	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	0.5550080752824423	[515,221]	[155,325]	6	hSpCas9	negative selection	337455
50713916	50713939	19	-	26472758	KBM7	viability	ACACTGGCGGCCCAGACCGAAGG	SHANK1	ENSG00000161681	0.9206240953277786	[647,525]	[463,568]	8	hSpCas9	negative selection	337456
50711460	50711483	19	+	26472758	KBM7	viability	GGTGCTGAGAGTGACCCCGCTGG	SHANK1	ENSG00000161681	-0.2449434143213245	[141,86]	[24,61]	-2	hSpCas9	negative selection	337457
50702503	50702526	19	-	26472758	KBM7	viability	GTCCTACCAGGCCCAAGCCGAGG	SHANK1	ENSG00000161681	1.5876546073617788	[344,178]	[424,301]	9	hSpCas9	negative selection	337458
50702481	50702504	19	-	26472758	KBM7	viability	GGGGAGATCTCCCTGAGCAAGGG	SHANK1	ENSG00000161681	0.08819805936934436	[462,327]	[200,189]	0	hSpCas9	negative selection	337459
50688034	50688057	19	-	26472758	KBM7	viability	GAACGGGCAGAATGTGGTGAAGG	SHANK1	ENSG00000161681	-0.01411851357194717	[532,495]	[223,253]	0	hSpCas9	negative selection	337460
50688016	50688039	19	-	26472758	KBM7	viability	GAAGGTCGGCCACCGACAGGTGG	SHANK1	ENSG00000161681	0.08963212446017804	[449,534]	[234,262]	0	hSpCas9	negative selection	337461
50687997	50688020	19	-	26472758	KBM7	viability	GTGGTGAACATGATCCGCCAAGG	SHANK1	ENSG00000161681	0.17463526049404798	[1120,856]	[628,422]	1	hSpCas9	negative selection	337462
50716743	50716766	19	+	26472758	Raji	viability	GCCCTGGAGGCCTCTAACAGAGG	SHANK1	ENSG00000161681	0.019920694123260085	[186]	[43]	0	hSpCas9	negative selection	528571
50669174	50669197	19	+	26472758	Raji	viability	GGTGGGGACGTGGTGGGTGGCGG	SHANK1	ENSG00000161681	-2.717044900042946	[169]	[5]	-9	hSpCas9	negative selection	528572
50716341	50716364	19	+	26472758	Raji	viability	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	-0.2672516098446073	[222]	[42]	-2	hSpCas9	negative selection	528573
50713916	50713939	19	-	26472758	Raji	viability	ACACTGGCGGCCCAGACCGAAGG	SHANK1	ENSG00000161681	0.5827936526319253	[350]	[121]	5	hSpCas9	negative selection	528574
50711460	50711483	19	+	26472758	Raji	viability	GGTGCTGAGAGTGACCCCGCTGG	SHANK1	ENSG00000161681	2.446185448825358	[33]	[42]	9	hSpCas9	negative selection	528575
50702503	50702526	19	-	26472758	Raji	viability	GTCCTACCAGGCCCAAGCCGAGG	SHANK1	ENSG00000161681	0.48177905015509737	[107]	[34]	4	hSpCas9	negative selection	528576
50702481	50702504	19	-	26472758	Raji	viability	GGGGAGATCTCCCTGAGCAAGGG	SHANK1	ENSG00000161681	0.3606699646558312	[197]	[58]	3	hSpCas9	negative selection	528577
50688034	50688057	19	-	26472758	Raji	viability	GAACGGGCAGAATGTGGTGAAGG	SHANK1	ENSG00000161681	0.11189901649609252	[318]	[79]	1	hSpCas9	negative selection	528578
50688016	50688039	19	-	26472758	Raji	viability	GAAGGTCGGCCACCGACAGGTGG	SHANK1	ENSG00000161681	-0.15170368594353148	[291]	[60]	-1	hSpCas9	negative selection	528579
50687997	50688020	19	-	26472758	Raji	viability	GTGGTGAACATGATCCGCCAAGG	SHANK1	ENSG00000161681	0.3169203927147686	[466]	[134]	3	hSpCas9	negative selection	528580
50716743	50716766	19	+	26472758	K562	viability	GCCCTGGAGGCCTCTAACAGAGG	SHANK1	ENSG00000161681	-1.0969036180142218	[336]	[132]	-6	hSpCas9	negative selection	719689
50669174	50669197	19	+	26472758	K562	viability	GGTGGGGACGTGGTGGGTGGCGG	SHANK1	ENSG00000161681	-1.166693068398597	[366]	[137]	-6	hSpCas9	negative selection	719690
50716341	50716364	19	+	26472758	K562	viability	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	0.05101293521083433	[270]	[236]	0	hSpCas9	negative selection	719691
50713916	50713939	19	-	26472758	K562	viability	ACACTGGCGGCCCAGACCGAAGG	SHANK1	ENSG00000161681	0.3487553874811825	[479]	[515]	2	hSpCas9	negative selection	719692
50711460	50711483	19	+	26472758	K562	viability	GGTGCTGAGAGTGACCCCGCTGG	SHANK1	ENSG00000161681	1.1241244939487351	[49]	[91]	8	hSpCas9	negative selection	719693
50702503	50702526	19	-	26472758	K562	viability	GTCCTACCAGGCCCAAGCCGAGG	SHANK1	ENSG00000161681	-1.457781448339083	[204]	[62]	-6	hSpCas9	negative selection	719694
50702481	50702504	19	-	26472758	K562	viability	GGGGAGATCTCCCTGAGCAAGGG	SHANK1	ENSG00000161681	-0.006277343604103924	[325]	[273]	0	hSpCas9	negative selection	719695
50688034	50688057	19	-	26472758	K562	viability	GAACGGGCAGAATGTGGTGAAGG	SHANK1	ENSG00000161681	0.6806794980328044	[387]	[524]	5	hSpCas9	negative selection	719696
50688016	50688039	19	-	26472758	K562	viability	GAAGGTCGGCCACCGACAGGTGG	SHANK1	ENSG00000161681	0.12500356072167626	[427]	[393]	0	hSpCas9	negative selection	719697
50687997	50688020	19	-	26472758	K562	viability	GTGGTGAACATGATCCGCCAAGG	SHANK1	ENSG00000161681	-0.48264187088189436	[628]	[379]	-3	hSpCas9	negative selection	719698
50711970	50711993	19	+	26627737	DLD1	viability	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	-0.055173153207492054	[307]	[127,105,50]	0	hSpCas9	negative selection	806374
50713923	50713946	19	+	26627737	DLD1	viability	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	0.9932479860059702	[434]	[314,299,207]	8	hSpCas9	negative selection	806375
50714231	50714254	19	-	26627737	DLD1	viability	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	-0.21542729151815176	[442]	[131,63,153]	-2	hSpCas9	negative selection	806376
50715658	50715681	19	-	26627737	DLD1	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.6884873749260272	[1569]	[241,308,354]	-6	hSpCas9	negative selection	806377
50716341	50716364	19	+	26627737	DLD1	viability	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	-0.6875265346641484	[354]	[36,42,117]	-6	hSpCas9	negative selection	806378
50716886	50716909	19	+	26627737	DLD1	viability	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	0.302672082976573	[130]	[32,124,3]	3	hSpCas9	negative selection	806379
50711970	50711993	19	+	26627737	GBM cells	viability after 5 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	0.07615425982975843	[152]	[81,90]	1	hSpCas9	negative selection	888689
50713923	50713946	19	+	26627737	GBM cells	viability after 5 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	0.2382240480012846	[263]	[157,175]	4	hSpCas9	negative selection	888690
50714231	50714254	19	-	26627737	GBM cells	viability after 5 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	0.41555641700290774	[208]	[159,138]	6	hSpCas9	negative selection	888691
50715658	50715681	19	-	26627737	GBM cells	viability after 5 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	1.3290582665547377	[94]	[119,135]	9	hSpCas9	negative selection	888692
50716341	50716364	19	+	26627737	GBM cells	viability after 5 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	-0.29931223532001006	[147]	[60,67]	-5	hSpCas9	negative selection	888693
50716886	50716909	19	+	26627737	GBM cells	viability after 5 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	0.8697675292261691	[24]	[22,25]	9	hSpCas9	negative selection	888694
50711970	50711993	19	+	26627737	GBM cells	viability after 13 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	0.8969333769862939	[152]	[142,163]	9	hSpCas9	negative selection	971004
50713923	50713946	19	+	26627737	GBM cells	viability after 13 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	0.5255992375740681	[263]	[262,159]	6	hSpCas9	negative selection	971005
50714231	50714254	19	-	26627737	GBM cells	viability after 13 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	0.1209622444609158	[208]	[135,112]	1	hSpCas9	negative selection	971006
50715658	50715681	19	-	26627737	GBM cells	viability after 13 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	1.4098149371784399	[94]	[115,153]	9	hSpCas9	negative selection	971007
50716341	50716364	19	+	26627737	GBM cells	viability after 13 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	-0.2481792240015419	[147]	[44,85]	-3	hSpCas9	negative selection	971008
50716886	50716909	19	+	26627737	GBM cells	viability after 13 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	1.3635844269828155	[24]	[51,20]	9	hSpCas9	negative selection	971009
50711970	50711993	19	+	26627737	GBM cells	viability after 21 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	1.210310464847333	[152]	[207,177]	9	hSpCas9	negative selection	1053319
50713923	50713946	19	+	26627737	GBM cells	viability after 21 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	0.35416448794807087	[263]	[198,168]	3	hSpCas9	negative selection	1053320
50714231	50714254	19	-	26627737	GBM cells	viability after 21 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	-0.053949986336739336	[208]	[123,95]	0	hSpCas9	negative selection	1053321
50715658	50715681	19	-	26627737	GBM cells	viability after 21 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	1.8850342858794793	[94]	[210,171]	9	hSpCas9	negative selection	1053322
50716341	50716364	19	+	26627737	GBM cells	viability after 21 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	-0.1619691988693044	[147]	[74,68]	-1	hSpCas9	negative selection	1053323
50716886	50716909	19	+	26627737	GBM cells	viability after 21 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	0.8550073233274849	[24]	[22,25]	8	hSpCas9	negative selection	1053324
50711970	50711993	19	+	26627737	RPE1	viability after 9 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	2.4956630370553294	[181]	[371,255]	9	hSpCas9	negative selection	1135634
50713923	50713946	19	+	26627737	RPE1	viability after 9 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	0.3392041971904465	[927]	[415,304]	2	hSpCas9	negative selection	1135635
50714231	50714254	19	-	26627737	RPE1	viability after 9 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	-1.3855239479975836	[1484]	[211,133]	-7	hSpCas9	negative selection	1135636
50715658	50715681	19	-	26627737	RPE1	viability after 9 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.45028354954945216	[1247]	[542,521]	3	hSpCas9	negative selection	1135637
50716341	50716364	19	+	26627737	RPE1	viability after 9 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	-0.81449757975155	[600]	[99,115]	-5	hSpCas9	negative selection	1135638
50716886	50716909	19	+	26627737	RPE1	viability after 9 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	-0.3762685062293354	[79]	[10,29]	-3	hSpCas9	negative selection	1135639
50711970	50711993	19	+	26627737	RPE1	viability after 12 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	1.7045659735577874	[181]	[171,145]	8	hSpCas9	negative selection	1217949
50713923	50713946	19	+	26627737	RPE1	viability after 12 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	0.6296260487676643	[927]	[478,286]	4	hSpCas9	negative selection	1217950
50714231	50714254	19	-	26627737	RPE1	viability after 12 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	-0.9556376297429195	[1484]	[195,215]	-6	hSpCas9	negative selection	1217951
50715658	50715681	19	-	26627737	RPE1	viability after 12 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.5627431651516948	[1247]	[435,557]	4	hSpCas9	negative selection	1217952
50716341	50716364	19	+	26627737	RPE1	viability after 12 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	-0.7053368468228441	[600]	[133,61]	-5	hSpCas9	negative selection	1217953
50716886	50716909	19	+	26627737	RPE1	viability after 12 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	-0.615520485844498	[79]	[14,12]	-4	hSpCas9	negative selection	1217954
50711970	50711993	19	+	26627737	RPE1	viability after 15 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	2.4266826668611357	[181]	[343,211]	9	hSpCas9	negative selection	1300264
50713923	50713946	19	+	26627737	RPE1	viability after 15 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	0.6461826058562908	[927]	[616,211]	4	hSpCas9	negative selection	1300265
50714231	50714254	19	-	26627737	RPE1	viability after 15 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	-1.4586473248783767	[1484]	[161,143]	-7	hSpCas9	negative selection	1300266
50715658	50715681	19	-	26627737	RPE1	viability after 15 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.7853474585687137	[1247]	[582,632]	5	hSpCas9	negative selection	1300267
50716341	50716364	19	+	26627737	RPE1	viability after 15 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	-0.5513787638284544	[600]	[227,7]	-3	hSpCas9	negative selection	1300268
50716886	50716909	19	+	26627737	RPE1	viability after 15 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	0.23523513190584877	[79]	[46,6]	1	hSpCas9	negative selection	1300269
50711970	50711993	19	+	26627737	RPE1	viability after 18 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	1.6577774464676684	[181]	[197,108]	8	hSpCas9	negative selection	1382579
50713923	50713946	19	+	26627737	RPE1	viability after 18 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	0.5065177206872412	[927]	[494,206]	3	hSpCas9	negative selection	1382580
50714231	50714254	19	-	26627737	RPE1	viability after 18 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	-2.509211409611254	[1484]	[110,26]	-8	hSpCas9	negative selection	1382581
50715658	50715681	19	-	26627737	RPE1	viability after 18 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.6847741788456856	[1247]	[435,653]	4	hSpCas9	negative selection	1382582
50716341	50716364	19	+	26627737	RPE1	viability after 18 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	-0.11487821314780683	[600]	[288,0]	0	hSpCas9	negative selection	1382583
50716886	50716909	19	+	26627737	RPE1	viability after 18 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	0.15554878057013433	[79]	[39,6]	1	hSpCas9	negative selection	1382584
50711970	50711993	19	+	26627737	HeLa	viability after 8 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	0.20400357137098923	[221]	[64,137,119]	2	hSpCas9	negative selection	1464894
50713923	50713946	19	+	26627737	HeLa	viability after 8 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	0.06378909268232036	[633]	[613,171,159]	0	hSpCas9	negative selection	1464895
50714231	50714254	19	-	26627737	HeLa	viability after 8 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	0.04212391093270307	[435]	[302,85,218]	0	hSpCas9	negative selection	1464896
50715658	50715681	19	-	26627737	HeLa	viability after 8 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.5015037088425064	[915]	[373,342,156]	-5	hSpCas9	negative selection	1464897
50716341	50716364	19	+	26627737	HeLa	viability after 8 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	0.5559207207676622	[271]	[146,223,146]	5	hSpCas9	negative selection	1464898
50716886	50716909	19	+	26627737	HeLa	viability after 8 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	1.2573509483182301	[56]	[72,64,43]	8	hSpCas9	negative selection	1464899
50711970	50711993	19	+	26627737	HeLa	viability after 12 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	0.4698808676682301	[221]	[111,171,91]	4	hSpCas9	negative selection	1547209
50713923	50713946	19	+	26627737	HeLa	viability after 12 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	0.4013508537091358	[633]	[410,402,219]	3	hSpCas9	negative selection	1547210
50714231	50714254	19	-	26627737	HeLa	viability after 12 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	-0.6609122995352714	[435]	[163,69,113]	-5	hSpCas9	negative selection	1547211
50715658	50715681	19	-	26627737	HeLa	viability after 12 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.5978905263946869	[915]	[213,318,208]	-5	hSpCas9	negative selection	1547212
50716341	50716364	19	+	26627737	HeLa	viability after 12 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	1.0384011363104082	[271]	[395,168,138]	7	hSpCas9	negative selection	1547213
50716886	50716909	19	+	26627737	HeLa	viability after 12 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	1.2213004919229165	[56]	[46,59,56]	8	hSpCas9	negative selection	1547214
50711970	50711993	19	+	26627737	HeLa	viability after 15 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	0.30930651327508163	[221]	[21,107,214]	2	hSpCas9	negative selection	1629524
50713923	50713946	19	+	26627737	HeLa	viability after 15 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	-0.10072772342412617	[633]	[199,228,297]	-1	hSpCas9	negative selection	1629525
50714231	50714254	19	-	26627737	HeLa	viability after 15 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	0.12337140342774364	[435]	[303,160,106]	1	hSpCas9	negative selection	1629526
50715658	50715681	19	-	26627737	HeLa	viability after 15 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.6709321030454878	[915]	[343,113,243]	-5	hSpCas9	negative selection	1629527
50716341	50716364	19	+	26627737	HeLa	viability after 15 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	0.29732943893268826	[271]	[122,141,143]	2	hSpCas9	negative selection	1629528
50716886	50716909	19	+	26627737	HeLa	viability after 15 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	0.24855633083779027	[56]	[18,33,29]	2	hSpCas9	negative selection	1629529
50711970	50711993	19	+	26627737	HeLa	viability after 18 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	0.3283688027525166	[221]	[13,93,214]	2	hSpCas9	negative selection	1711839
50713923	50713946	19	+	26627737	HeLa	viability after 18 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	-0.11151533284379112	[633]	[135,182,297]	-1	hSpCas9	negative selection	1711840
50714231	50714254	19	-	26627737	HeLa	viability after 18 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	0.11481504841889831	[435]	[205,127,106]	1	hSpCas9	negative selection	1711841
50715658	50715681	19	-	26627737	HeLa	viability after 18 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.6455977818046242	[915]	[235,97,243]	-5	hSpCas9	negative selection	1711842
50716341	50716364	19	+	26627737	HeLa	viability after 18 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	0.3136283864361747	[271]	[81,121,143]	2	hSpCas9	negative selection	1711843
50716886	50716909	19	+	26627737	HeLa	viability after 18 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	0.18050487531899373	[56]	[11,25,29]	1	hSpCas9	negative selection	1711844
50711970	50711993	19	+	26627737	HCT116	viability after 6 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	-1.5724963119776874	[313]	[33,6]	-7	hSpCas9	negative selection	1794154
50713923	50713946	19	+	26627737	HCT116	viability after 6 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	-0.05191407384317929	[599]	[148,58]	0	hSpCas9	negative selection	1794155
50714231	50714254	19	-	26627737	HCT116	viability after 6 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	1.3510502465417278	[797]	[174,399]	7	hSpCas9	negative selection	1794156
50715658	50715681	19	-	26627737	HCT116	viability after 6 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	1.7765731345824574	[667]	[275,405]	8	hSpCas9	negative selection	1794157
50716341	50716364	19	+	26627737	HCT116	viability after 6 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	1.0408128147228386	[350]	[21,163]	5	hSpCas9	negative selection	1794158
50716886	50716909	19	+	26627737	HCT116	viability after 6 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	-0.6883825124615872	[112]	[1,15]	-4	hSpCas9	negative selection	1794159
50711970	50711993	19	+	26627737	HCT116	viability after 8 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	1.652729093990221	[58]	[95,144,65]	9	hSpCas9	negative selection	1876469
50713923	50713946	19	+	26627737	HCT116	viability after 8 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	0.12213338730430123	[395]	[269,202,239]	1	hSpCas9	negative selection	1876470
50714231	50714254	19	-	26627737	HCT116	viability after 8 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	0.927581887136818	[120]	[105,139,133]	8	hSpCas9	negative selection	1876471
50715658	50715681	19	-	26627737	HCT116	viability after 8 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.5281830672674285	[586]	[211,264,195]	-6	hSpCas9	negative selection	1876472
50716341	50716364	19	+	26627737	HCT116	viability after 8 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	-0.6261770721717331	[326]	[98,141,108]	-6	hSpCas9	negative selection	1876473
50716886	50716909	19	+	26627737	HCT116	viability after 8 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	-0.3026125411693792	[79]	[64,27,14]	-4	hSpCas9	negative selection	1876474
50711970	50711993	19	+	26627737	HCT116	viability after 9 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	2.0607258161982043	[313]	[222,449]	9	hSpCas9	negative selection	1958784
50713923	50713946	19	+	26627737	HCT116	viability after 9 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	-0.972153440860998	[599]	[60,97]	-6	hSpCas9	negative selection	1958785
50714231	50714254	19	-	26627737	HCT116	viability after 9 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	-0.7018321233314271	[797]	[192,81]	-5	hSpCas9	negative selection	1958786
50715658	50715681	19	-	26627737	HCT116	viability after 9 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	1.3654469780960306	[667]	[620,331]	8	hSpCas9	negative selection	1958787
50716341	50716364	19	+	26627737	HCT116	viability after 9 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	-1.124072654248994	[350]	[42,42]	-7	hSpCas9	negative selection	1958788
50716886	50716909	19	+	26627737	HCT116	viability after 9 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	0.8958745006498443	[112]	[111,11]	6	hSpCas9	negative selection	1958789
50711970	50711993	19	+	26627737	HCT116	viability after 12 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	2.164760672371166	[58]	[139,138,137]	9	hSpCas9	negative selection	2041099
50713923	50713946	19	+	26627737	HCT116	viability after 12 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	0.19520722850811534	[395]	[176,313,230]	2	hSpCas9	negative selection	2041100
50714231	50714254	19	-	26627737	HCT116	viability after 12 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	0.9827517330284492	[120]	[105,136,135]	8	hSpCas9	negative selection	2041101
50715658	50715681	19	-	26627737	HCT116	viability after 12 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.3262117799046711	[586]	[397,251,505]	3	hSpCas9	negative selection	2041102
50716341	50716364	19	+	26627737	HCT116	viability after 12 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	-0.05374055301664987	[326]	[184,124,183]	0	hSpCas9	negative selection	2041103
50716886	50716909	19	+	26627737	HCT116	viability after 12 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	0.6486083871487813	[79]	[27,104,68]	6	hSpCas9	negative selection	2041104
50711970	50711993	19	+	26627737	HCT116	viability after 15 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	1.5599490087284824	[58]	[146,104,53]	9	hSpCas9	negative selection	2123414
50713923	50713946	19	+	26627737	HCT116	viability after 15 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	0.41618185614006264	[395]	[301,285,321]	4	hSpCas9	negative selection	2123415
50714231	50714254	19	-	26627737	HCT116	viability after 15 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	1.2641889312392256	[120]	[183,167,150]	8	hSpCas9	negative selection	2123416
50715658	50715681	19	-	26627737	HCT116	viability after 15 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.20942848835283567	[586]	[500,302,378]	2	hSpCas9	negative selection	2123417
50716341	50716364	19	+	26627737	HCT116	viability after 15 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	-0.6921946782331662	[326]	[71,129,140]	-6	hSpCas9	negative selection	2123418
50716886	50716909	19	+	26627737	HCT116	viability after 15 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	0.06337384494949516	[79]	[28,88,23]	0	hSpCas9	negative selection	2123419
50711970	50711993	19	+	26627737	HCT116	viability after 18 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	1.5753077700454239	[58]	[116,88,46]	9	hSpCas9	negative selection	2205729
50713923	50713946	19	+	26627737	HCT116	viability after 18 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	0.13823482833419098	[395]	[151,286,186]	1	hSpCas9	negative selection	2205730
50714231	50714254	19	-	26627737	HCT116	viability after 18 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	1.1510222182638692	[120]	[123,206,49]	8	hSpCas9	negative selection	2205731
50715658	50715681	19	-	26627737	HCT116	viability after 18 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.4460634810014328	[586]	[562,286,312]	4	hSpCas9	negative selection	2205732
50716341	50716364	19	+	26627737	HCT116	viability after 18 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	0.25959547333389443	[326]	[147,109,320]	2	hSpCas9	negative selection	2205733
50716886	50716909	19	+	26627737	HCT116	viability after 18 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	-0.9011593696173883	[79]	[13,15,32]	-7	hSpCas9	negative selection	2205734
50709416	50709439	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGCGTGAGCCACTGCGCCCGG	SHANK1	ENSG00000161681	-0.04533809600197003	[16,0]	[1,0]	0	dCas9-VP64	positive selection	2431220
50685647	50685670	19	-	25494202	A375	resistance to PLX-4720 (puromycin)	TCACTGCAACCTCTGCCCCCCGG	SHANK1	ENSG00000161681	-1.2513288674205318	[297,436]	[21,46]	-7	dCas9-VP64	positive selection	2446536
50717081	50717104	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	AAGGAGGCTGGACACACCCTCGG	SHANK1	ENSG00000161681	-0.2006797468989161	[154,153]	[20,38]	-1	dCas9-VP64	positive selection	2447182
50717054	50717077	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	CTACCCCCACTGCCCAAGATAGG	SHANK1	ENSG00000161681	-1.1612583023186474	[158,185]	[16,15]	-6	dCas9-VP64	positive selection	2447183
50717020	50717043	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGCGCTATTCGGTGGTCAAGCGG	SHANK1	ENSG00000161681	2.195038408371426	[11,76]	[34,56]	7	dCas9-VP64	positive selection	2447184
50709416	50709439	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGCGTGAGCCACTGCGCCCGG	SHANK1	ENSG00000161681	-1.0099528387584376	[28,142]	[9,15]	-8	dCas9-VP64	positive selection	2526475
50685647	50685670	19	-	25494202	A375	resistance to PLX-4720 (zeocin)	TCACTGCAACCTCTGCCCCCCGG	SHANK1	ENSG00000161681	0.4244343490827851	[184,278]	[65,133]	3	dCas9-VP64	positive selection	2541791
50717081	50717104	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	AAGGAGGCTGGACACACCCTCGG	SHANK1	ENSG00000161681	-0.15605555365669949	[173,149]	[55,38]	-1	dCas9-VP64	positive selection	2542437
50717054	50717077	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	CTACCCCCACTGCCCAAGATAGG	SHANK1	ENSG00000161681	0.3196605504243149	[115,114]	[70,24]	2	dCas9-VP64	positive selection	2542438
50717020	50717043	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGCGCTATTCGGTGGTCAAGCGG	SHANK1	ENSG00000161681	3.2665889274930224	[220,46]	[870,12]	9	dCas9-VP64	positive selection	2542439
50703801	50703824	19	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CCAGGAGTCCCCCAAGTACGCGG	SHANK1	ENSG00000161681	-0.30578287844976204	[4,4]	[3,2]	-4	hSpCas9	positive selection	3020111
50712045	50712068	19	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCTGACCCCTCTGTTCCACACGG	SHANK1	ENSG00000161681	-0.53088064343185	[3,3]	[2,1]	-7	hSpCas9	positive selection	3020112
50714231	50714254	19	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	-0.46619247319458806	[3,3]	[2,1]	-6	hSpCas9	positive selection	3020113
50669074	50669097	19	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGAGGGGGCCACCAGAGCCAGGG	SHANK1	ENSG00000161681	0.6340886025939099	[2,2]	[1,5]	9	hSpCas9	positive selection	3020114
50703801	50703824	19	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CCAGGAGTCCCCCAAGTACGCGG	SHANK1	ENSG00000161681	0.14625333522052064	[4,4]	[4,2]	2	hSpCas9	positive selection	3087969
50712045	50712068	19	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCTGACCCCTCTGTTCCACACGG	SHANK1	ENSG00000161681	-0.4823042397944661	[3,3]	[3,0]	-7	hSpCas9	positive selection	3087970
50714231	50714254	19	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	-0.7124517414166793	[3,3]	[2,0]	-8	hSpCas9	positive selection	3087971
50669074	50669097	19	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGAGGGGGCCACCAGAGCCAGGG	SHANK1	ENSG00000161681	0.04117305771680685	[2,2]	[2,0]	0	hSpCas9	positive selection	3087972
50716892	50716915		-	24336571	A375	resistance to PLX after 7 days	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.28284719164032923	[4,3]	[5,5]	7	hSpCas9	positive selection	3144052
50716344	50716367		+	24336571	A375	resistance to PLX after 7 days	GTTGGCATCGCGGCCGGAGGTGG	SHANK1	ENSG00000161681	0.29080967538186386	[5,4]	[6,6]	7	hSpCas9	positive selection	3144053
50716443	50716466		-	24336571	A375	resistance to PLX after 7 days	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.21012786793872795	[23,21]	[23,28]	6	hSpCas9	positive selection	3144054
50716884	50716907		+	24336571	A375	resistance to PLX after 7 days	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.2841052010298192	[14,18]	[20,19]	7	hSpCas9	positive selection	3144055
50716892	50716915		-	24336571	A375	resistance to PLX after 14 days	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.24102392031939157	[8,3]	[2,3]	2	hSpCas9	positive selection	3201845
50716344	50716367		+	24336571	A375	resistance to PLX after 14 days	GTTGGCATCGCGGCCGGAGGTGG	SHANK1	ENSG00000161681	0.536258198048374	[4,7]	[2,4]	5	hSpCas9	positive selection	3201846
50716443	50716466		-	24336571	A375	resistance to PLX after 14 days	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.14154645528468868	[31,10]	[11,8]	1	hSpCas9	positive selection	3201847
50716884	50716907		+	24336571	A375	resistance to PLX after 14 days	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	1.7117172999760846	[19,13]	[23,27]	9	hSpCas9	positive selection	3201848
50716892	50716915		-	24336571	A375	viability after 7 days	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	-0.5444272992805103	[6]	[4,3]	-7	hSpCas9	negative selection	3259638
50716344	50716367		+	24336571	A375	viability after 7 days	GTTGGCATCGCGGCCGGAGGTGG	SHANK1	ENSG00000161681	-0.07437383301026523	[5]	[5,4]	-1	hSpCas9	negative selection	3259639
50716443	50716466		-	24336571	A375	viability after 7 days	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.035828519395127545	[22]	[23,21]	0	hSpCas9	negative selection	3259640
50716884	50716907		+	24336571	A375	viability after 7 days	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	-0.12925579632246076	[18]	[14,18]	-2	hSpCas9	negative selection	3259641
50716892	50716915		-	24336571	A375	viability after 14 days	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	-0.05640256943776567	[6]	[8,3]	0	hSpCas9	negative selection	3317431
50716344	50716367		+	24336571	A375	viability after 14 days	GTTGGCATCGCGGCCGGAGGTGG	SHANK1	ENSG00000161681	0.12727566508195765	[5]	[4,7]	1	hSpCas9	negative selection	3317432
50716443	50716466		-	24336571	A375	viability after 14 days	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	-0.040316191473351304	[22]	[31,10]	0	hSpCas9	negative selection	3317433
50716884	50716907		+	24336571	A375	viability after 14 days	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	-0.09337317147777835	[18]	[19,13]	-1	hSpCas9	negative selection	3317434
50716443	50716466	19	-	27383988	293T	resistance to West Nile virus (flavivirus)	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	-1.9786879804542497	[602,602]	[0,0]	-9	hSpCas9	positive selection	3392297
50716367	50716390	19	-	27383988	293T	resistance to West Nile virus (flavivirus)	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.6968700989410402	[247,247]	[0,0]	-5	hSpCas9	positive selection	3392298
50715706	50715729	19	+	27383988	293T	resistance to West Nile virus (flavivirus)	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	-0.8407058715146917	[273,273]	[0,0]	-6	hSpCas9	positive selection	3392299
50703801	50703824	19	-	26780180	HT29	viability (Avana library 4 designs)	CCAGGAGTCCCCCAAGTACGCGG	SHANK1	ENSG00000161681	-0.524453245476242	[]	[]	-7	hSpCas9	negative selection	3458615
50712045	50712068	19	-	26780180	HT29	viability (Avana library 4 designs)	GCTGACCCCTCTGTTCCACACGG	SHANK1	ENSG00000161681	1.0944840692456	[]	[]	4	hSpCas9	negative selection	3458616
50714231	50714254	19	-	26780180	HT29	viability (Avana library 4 designs)	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	1.27175262611529	[]	[]	5	hSpCas9	negative selection	3458617
50669073	50669096	19	+	26780180	HT29	viability (Avana library 4 designs)	GGAGGGGGCCACCAGAGCCAGGG	SHANK1	ENSG00000161681	3.12185927922793	[]	[]	8	hSpCas9	negative selection	3458618
50714231	50714254	19	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	2.5019424056976	[]	[]	4	hSpCas9	negative selection	3558142
50703801	50703824	19	-	26780180	A375	viability (Avana lentiCRISPRv2)	CCAGGAGTCCCCCAAGTACGCGG	SHANK1	ENSG00000161681	7.78510926147905	[]	[]	9	hSpCas9	negative selection	3558143
50712045	50712068	19	-	26780180	A375	viability (Avana lentiCRISPRv2)	GCTGACCCCTCTGTTCCACACGG	SHANK1	ENSG00000161681	0.66403277869006	[]	[]	0	hSpCas9	negative selection	3558144
50669073	50669096	19	+	26780180	A375	viability (Avana lentiCRISPRv2)	GGAGGGGGCCACCAGAGCCAGGG	SHANK1	ENSG00000161681	-1.87676226060727	[]	[]	-2	hSpCas9	negative selection	3558145
50703544	50703567	19	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGGCCCGCTCTCCATCCCGAGGG	SHANK1	ENSG00000161681	-1.78677987591722	[]	[]	-2	hSpCas9	negative selection	3558146
50702486	50702509	19	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCTCAGGGAGATCTCCCCCTCGG	SHANK1	ENSG00000161681	5.27204145696929	[]	[]	8	hSpCas9	negative selection	3558147
50714231	50714254	19	-	26780180	A375	viability (Avana lentiGuide)	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	2.313882882114	[]	[]	2	hSpCas9	negative selection	3666801
50703801	50703824	19	-	26780180	A375	viability (Avana lentiGuide)	CCAGGAGTCCCCCAAGTACGCGG	SHANK1	ENSG00000161681	-5.31220040953388	[]	[]	-8	hSpCas9	negative selection	3666802
50712045	50712068	19	-	26780180	A375	viability (Avana lentiGuide)	GCTGACCCCTCTGTTCCACACGG	SHANK1	ENSG00000161681	6.29925508549622	[]	[]	5	hSpCas9	negative selection	3666803
50669073	50669096	19	+	26780180	A375	viability (Avana lentiGuide)	GGAGGGGGCCACCAGAGCCAGGG	SHANK1	ENSG00000161681	21.4623369247084	[]	[]	9	hSpCas9	negative selection	3666804
50703544	50703567	19	-	26780180	A375	viability (Avana lentiGuide)	GGGCCCGCTCTCCATCCCGAGGG	SHANK1	ENSG00000161681	5.24087126343773	[]	[]	4	hSpCas9	negative selection	3666805
50702486	50702509	19	+	26780180	A375	viability (Avana lentiGuide)	GCTCAGGGAGATCTCCCCCTCGG	SHANK1	ENSG00000161681	12.5121191376818	[]	[]	7	hSpCas9	negative selection	3666806
50714231	50714254	19	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	0.22925486784046512	[4]	[5,4]	6	hSpCas9	positive selection	3775408
50703801	50703824	19	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CCAGGAGTCCCCCAAGTACGCGG	SHANK1	ENSG00000161681	0.3401784379390832	[5]	[7,6]	8	hSpCas9	positive selection	3775409
50712045	50712068	19	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCTGACCCCTCTGTTCCACACGG	SHANK1	ENSG00000161681	-0.07830542131428869	[4]	[4,4]	-1	hSpCas9	positive selection	3775410
50669073	50669096	19	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGAGGGGGCCACCAGAGCCAGGG	SHANK1	ENSG00000161681	-0.034233432090399155	[4]	[5,3]	0	hSpCas9	positive selection	3775411
50703544	50703567	19	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGGCCCGCTCTCCATCCCGAGGG	SHANK1	ENSG00000161681	0.13658899372273492	[4]	[4,4]	3	hSpCas9	positive selection	3775412
50702486	50702509	19	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCTCAGGGAGATCTCCCCCTCGG	SHANK1	ENSG00000161681	0.26793834564810703	[4]	[5,5]	7	hSpCas9	positive selection	3775413
50714231	50714254	19	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	0.29764125640518857	[5]	[5,5]	8	hSpCas9	positive selection	3884015
50703801	50703824	19	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CCAGGAGTCCCCCAAGTACGCGG	SHANK1	ENSG00000161681	0.0472079182425057	[6]	[6,4]	1	hSpCas9	positive selection	3884016
50712045	50712068	19	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCTGACCCCTCTGTTCCACACGG	SHANK1	ENSG00000161681	0.15487998976660947	[5]	[5,5]	3	hSpCas9	positive selection	3884017
50669073	50669096	19	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGAGGGGGCCACCAGAGCCAGGG	SHANK1	ENSG00000161681	-0.6490643482995074	[5]	[2,1]	-7	hSpCas9	positive selection	3884018
50703544	50703567	19	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGGCCCGCTCTCCATCCCGAGGG	SHANK1	ENSG00000161681	0.0658786307336559	[5]	[4,4]	1	hSpCas9	positive selection	3884019
50702486	50702509	19	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCTCAGGGAGATCTCCCCCTCGG	SHANK1	ENSG00000161681	-0.3458037834047898	[5]	[2,3]	-4	hSpCas9	positive selection	3884020
50716367	50716390	19	-	26780180	A375	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	1.33996993994885	[]	[]	7	hSpCas9	negative selection	3994070
50716892	50716915	19	-	26780180	A375	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.829485718017787	[]	[]	3	hSpCas9	negative selection	3994071
50715658	50715681	19	-	26780180	A375	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	1.00648264585604	[]	[]	4	hSpCas9	negative selection	3994072
50716443	50716466	19	-	26780180	A375	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	1.25027476910747	[]	[]	6	hSpCas9	negative selection	3994073
50715706	50715729	19	+	26780180	A375	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.527437820094534	[]	[]	1	hSpCas9	negative selection	3994074
50716884	50716907	19	+	26780180	A375	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.829140152852621	[]	[]	3	hSpCas9	negative selection	3994075
50716367	50716390	19	-	26780180	HT29	viability (GeCKOv2 library)	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	1.02389029688088	[]	[]	4	hSpCas9	negative selection	4102036
50716892	50716915	19	-	26780180	HT29	viability (GeCKOv2 library)	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.645713089120994	[]	[]	2	hSpCas9	negative selection	4102037
50715658	50715681	19	-	26780180	HT29	viability (GeCKOv2 library)	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.401965818280167	[]	[]	1	hSpCas9	negative selection	4102038
50716443	50716466	19	-	26780180	HT29	viability (GeCKOv2 library)	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.962796135294071	[]	[]	4	hSpCas9	negative selection	4102039
50715706	50715729	19	+	26780180	HT29	viability (GeCKOv2 library)	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.575281007025503	[]	[]	2	hSpCas9	negative selection	4102040
50716884	50716907	19	+	26780180	HT29	viability (GeCKOv2 library)	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.281944892800013	[]	[]	0	hSpCas9	negative selection	4102041
50716892	50716915	19	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	-0.16099664528612084	[2]	[1,1]	-4	hSpCas9	positive selection	4169983
50716344	50716367	19	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GTTGGCATCGCGGCCGGAGGTGG	SHANK1	ENSG00000161681	0.34188571005246937	[2]	[2,1]	7	hSpCas9	positive selection	4169984
50716443	50716466	19	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.10034160608224915	[4]	[2,3]	2	hSpCas9	positive selection	4169985
50716884	50716907	19	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.5094722077863574	[3]	[2,4]	9	hSpCas9	positive selection	4169986
50716892	50716915	19	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.22376296957891306	[2]	[2,3,0,0]	1	hSpCas9	positive selection	4234005
50716344	50716367	19	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GTTGGCATCGCGGCCGGAGGTGG	SHANK1	ENSG00000161681	-0.18822762025613296	[2]	[0,0,2,0]	-3	hSpCas9	positive selection	4234006
50716443	50716466	19	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.7496857366047294	[4]	[0,2,5,3]	5	hSpCas9	positive selection	4234007
50716884	50716907	19	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	-0.22549275751252035	[3]	[0,2,1,0]	-3	hSpCas9	positive selection	4234008
50716884	50716907	19	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.3721732669334634	[3]	[3,3]	7	hSpCas9	positive selection	4297618
50716892	50716915	19	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	-0.15181529688725803	[1]	[0,0]	-3	hSpCas9	positive selection	4297619
50715658	50715681	19	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.2197583363273464	[2]	[2,1]	4	hSpCas9	positive selection	4297620
50716443	50716466	19	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.023769637801272392	[4]	[4,2]	0	hSpCas9	positive selection	4361872
50716367	50716390	19	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.2533458519549485	[3]	[3,0]	-5	hSpCas9	positive selection	4361873
50715706	50715729	19	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.043787889092319704	[3]	[3,1]	0	hSpCas9	positive selection	4361874
50697617	50697639	19	-	27760321	OCIAML3	viability	CTCTTCCGGCATTATACCGTGG	SHANK1	ENSG00000161681	0.16728044022367805	[456,386]	[344,400]	2	hSpCas9	negative selection	4438735
50704472	50704494	19	-	27760321	OCIAML3	viability	CTGTATCGAGGTGCCGACAAGG	SHANK1	ENSG00000161681	0.3894389680226783	[491,448]	[476,487]	4	hSpCas9	negative selection	4438736
50712068	50712090	19	-	27760321	OCIAML3	viability	CCAACTACAAGGACCGTCGGGG	SHANK1	ENSG00000161681	-0.5580526055083921	[730,559]	[249,457]	-5	hSpCas9	negative selection	4438737
50686750	50686772	19	-	27760321	OCIAML3	viability	AAGCGGACCGTGTATCAGATGG	SHANK1	ENSG00000161681	-0.583966150515018	[365,325]	[125,250]	-5	hSpCas9	negative selection	4438738
50687995	50688017	19	-	27760321	OCIAML3	viability	GTGAACATGATCCGCCAAGGGG	SHANK1	ENSG00000161681	-0.2854149288940095	[326,314]	[178,241]	-3	hSpCas9	negative selection	4438739
50697617	50697639	19	-	27760321	OCIAML2	viability	CTCTTCCGGCATTATACCGTGG	SHANK1	ENSG00000161681	1.0044505920329845	[456,386]	[656,715]	9	hSpCas9	negative selection	4522198
50704472	50704494	19	-	27760321	OCIAML2	viability	CTGTATCGAGGTGCCGACAAGG	SHANK1	ENSG00000161681	-0.0025334216675246962	[491,448]	[308,472]	0	hSpCas9	negative selection	4522199
50712068	50712090	19	-	27760321	OCIAML2	viability	CCAACTACAAGGACCGTCGGGG	SHANK1	ENSG00000161681	-0.05878555507567329	[730,559]	[440,571]	-1	hSpCas9	negative selection	4522200
50686750	50686772	19	-	27760321	OCIAML2	viability	AAGCGGACCGTGTATCAGATGG	SHANK1	ENSG00000161681	-0.26137394269856334	[365,325]	[227,239]	-3	hSpCas9	negative selection	4522201
50687995	50688017	19	-	27760321	OCIAML2	viability	GTGAACATGATCCGCCAAGGGG	SHANK1	ENSG00000161681	0.2054623606138473	[326,314]	[286,316]	2	hSpCas9	negative selection	4522202
50697617	50697639	19	-	27760321	MV411	viability	CTCTTCCGGCATTATACCGTGG	SHANK1	ENSG00000161681	0.1891483405017336	[456,386]	[281,367]	1	hSpCas9	negative selection	4605661
50704472	50704494	19	-	27760321	MV411	viability	CTGTATCGAGGTGCCGACAAGG	SHANK1	ENSG00000161681	-0.06770358313287625	[491,448]	[188,456]	0	hSpCas9	negative selection	4605662
50712068	50712090	19	-	27760321	MV411	viability	CCAACTACAAGGACCGTCGGGG	SHANK1	ENSG00000161681	-0.562286738520052	[730,559]	[149,490]	-4	hSpCas9	negative selection	4605663
50686750	50686772	19	-	27760321	MV411	viability	AAGCGGACCGTGTATCAGATGG	SHANK1	ENSG00000161681	-0.37728835430609314	[365,325]	[87,306]	-3	hSpCas9	negative selection	4605664
50687995	50688017	19	-	27760321	MV411	viability	GTGAACATGATCCGCCAAGGGG	SHANK1	ENSG00000161681	0.21295946502277258	[326,314]	[187,332]	1	hSpCas9	negative selection	4605665
50697617	50697639	19	-	27760321	HL60	viability	CTCTTCCGGCATTATACCGTGG	SHANK1	ENSG00000161681	0.9275456486035892	[456,386]	[565,745]	8	hSpCas9	negative selection	4689124
50704472	50704494	19	-	27760321	HL60	viability	CTGTATCGAGGTGCCGACAAGG	SHANK1	ENSG00000161681	0.2583590585660462	[491,448]	[442,476]	3	hSpCas9	negative selection	4689125
50712068	50712090	19	-	27760321	HL60	viability	CCAACTACAAGGACCGTCGGGG	SHANK1	ENSG00000161681	-0.3331115222818448	[730,559]	[494,330]	-4	hSpCas9	negative selection	4689126
50686750	50686772	19	-	27760321	HL60	viability	AAGCGGACCGTGTATCAGATGG	SHANK1	ENSG00000161681	-0.2507453681563276	[365,325]	[276,194]	-3	hSpCas9	negative selection	4689127
50687995	50688017	19	-	27760321	HL60	viability	GTGAACATGATCCGCCAAGGGG	SHANK1	ENSG00000161681	0.23638914743018716	[326,314]	[290,328]	3	hSpCas9	negative selection	4689128
50697617	50697639	19	-	27760321	HT1080	viability	CTCTTCCGGCATTATACCGTGG	SHANK1	ENSG00000161681	-0.3084270732597197	[386,301]	[85,137]	-1	hSpCas9	negative selection	4772587
50704472	50704494	19	-	27760321	HT1080	viability	CTGTATCGAGGTGCCGACAAGG	SHANK1	ENSG00000161681	-0.8819343071844717	[448,350]	[85,86]	-4	hSpCas9	negative selection	4772588
50712068	50712090	19	-	27760321	HT1080	viability	CCAACTACAAGGACCGTCGGGG	SHANK1	ENSG00000161681	-0.9509316821490579	[559,436]	[96,108]	-4	hSpCas9	negative selection	4772589
50686750	50686772	19	-	27760321	HT1080	viability	AAGCGGACCGTGTATCAGATGG	SHANK1	ENSG00000161681	-0.6242834259278945	[325,254]	[97,49]	-3	hSpCas9	negative selection	4772590
50687995	50688017	19	-	27760321	HT1080	viability	GTGAACATGATCCGCCAAGGGG	SHANK1	ENSG00000161681	2.446252121904827	[314,245]	[756,446]	9	hSpCas9	negative selection	4772591
50697617	50697639	19	-	27760321	HT29	viability after 7 days	CTCTTCCGGCATTATACCGTGG	SHANK1	ENSG00000161681	-0.13893812499529995	[386,301]	[551,414,264]	-2	hSpCas9	negative selection	4856050
50704472	50704494	19	-	27760321	HT29	viability after 7 days	CTGTATCGAGGTGCCGACAAGG	SHANK1	ENSG00000161681	0.08541398737635666	[448,350]	[686,503,467]	1	hSpCas9	negative selection	4856051
50712068	50712090	19	-	27760321	HT29	viability after 7 days	CCAACTACAAGGACCGTCGGGG	SHANK1	ENSG00000161681	0.21835627204238445	[559,436]	[1001,383,881]	3	hSpCas9	negative selection	4856052
50686750	50686772	19	-	27760321	HT29	viability after 7 days	AAGCGGACCGTGTATCAGATGG	SHANK1	ENSG00000161681	0.5306514422281685	[325,254]	[693,434,511]	7	hSpCas9	negative selection	4856053
50687995	50688017	19	-	27760321	HT29	viability after 7 days	GTGAACATGATCCGCCAAGGGG	SHANK1	ENSG00000161681	0.010456739037760121	[314,245]	[443,330,326]	0	hSpCas9	negative selection	4856054
50697617	50697639	19	-	27760321	HT29	viability after 25 days	CTCTTCCGGCATTATACCGTGG	SHANK1	ENSG00000161681	0.045539032543866445	[386,301]	[426,366,424]	0	hSpCas9	negative selection	4939513
50704472	50704494	19	-	27760321	HT29	viability after 25 days	CTGTATCGAGGTGCCGACAAGG	SHANK1	ENSG00000161681	-0.2824170766072387	[448,350]	[333,434,358]	-3	hSpCas9	negative selection	4939514
50712068	50712090	19	-	27760321	HT29	viability after 25 days	CCAACTACAAGGACCGTCGGGG	SHANK1	ENSG00000161681	0.1005566140942506	[559,436]	[629,462,751]	1	hSpCas9	negative selection	4939515
50686750	50686772	19	-	27760321	HT29	viability after 25 days	AAGCGGACCGTGTATCAGATGG	SHANK1	ENSG00000161681	-0.03485945858041406	[325,254]	[331,231,416]	0	hSpCas9	negative selection	4939516
50687995	50688017	19	-	27760321	HT29	viability after 25 days	GTGAACATGATCCGCCAAGGGG	SHANK1	ENSG00000161681	0.28365146821438314	[314,245]	[357,467,340]	3	hSpCas9	negative selection	4939517
50697617	50697639	19	-	27760321	HT29	viability after 22 days	CTCTTCCGGCATTATACCGTGG	SHANK1	ENSG00000161681	-0.07517135793406464	[386,301]	[445,334,350]	-1	hSpCas9	negative selection	5022976
50704472	50704494	19	-	27760321	HT29	viability after 22 days	CTGTATCGAGGTGCCGACAAGG	SHANK1	ENSG00000161681	0.038926912728043855	[448,350]	[602,538,277]	0	hSpCas9	negative selection	5022977
50712068	50712090	19	-	27760321	HT29	viability after 22 days	CCAACTACAAGGACCGTCGGGG	SHANK1	ENSG00000161681	0.18809205617578267	[559,436]	[721,569,675]	2	hSpCas9	negative selection	5022978
50686750	50686772	19	-	27760321	HT29	viability after 22 days	AAGCGGACCGTGTATCAGATGG	SHANK1	ENSG00000161681	-0.4225645610724359	[325,254]	[122,196,436]	-4	hSpCas9	negative selection	5022979
50687995	50688017	19	-	27760321	HT29	viability after 22 days	GTGAACATGATCCGCCAAGGGG	SHANK1	ENSG00000161681	0.37232838699493076	[314,245]	[520,372,361]	4	hSpCas9	negative selection	5022980
50697617	50697639	19	-	27760321	HT29	viability after 19 days	CTCTTCCGGCATTATACCGTGG	SHANK1	ENSG00000161681	0.07837525748805059	[386,301]	[448,435,367]	0	hSpCas9	negative selection	5106439
50704472	50704494	19	-	27760321	HT29	viability after 19 days	CTGTATCGAGGTGCCGACAAGG	SHANK1	ENSG00000161681	-0.35570162209636885	[448,350]	[605,150,341]	-3	hSpCas9	negative selection	5106440
50712068	50712090	19	-	27760321	HT29	viability after 19 days	CCAACTACAAGGACCGTCGGGG	SHANK1	ENSG00000161681	-0.6067394508222058	[559,436]	[634,403,120]	-5	hSpCas9	negative selection	5106441
50686750	50686772	19	-	27760321	HT29	viability after 19 days	AAGCGGACCGTGTATCAGATGG	SHANK1	ENSG00000161681	0.15229951334536282	[325,254]	[337,334,428]	1	hSpCas9	negative selection	5106442
50687995	50688017	19	-	27760321	HT29	viability after 19 days	GTGAACATGATCCGCCAAGGGG	SHANK1	ENSG00000161681	-0.004234677155559807	[314,245]	[333,470,161]	0	hSpCas9	negative selection	5106443
50697617	50697639	19	-	27760321	HT29	viability after 16 days	CTCTTCCGGCATTATACCGTGG	SHANK1	ENSG00000161681	-0.21005803297707115	[386,301]	[353,237,411]	-2	hSpCas9	negative selection	5189902
50704472	50704494	19	-	27760321	HT29	viability after 16 days	CTGTATCGAGGTGCCGACAAGG	SHANK1	ENSG00000161681	-0.22302694889274352	[448,350]	[337,460,344]	-3	hSpCas9	negative selection	5189903
50712068	50712090	19	-	27760321	HT29	viability after 16 days	CCAACTACAAGGACCGTCGGGG	SHANK1	ENSG00000161681	0.32868340636553467	[559,436]	[924,522,678]	3	hSpCas9	negative selection	5189904
50686750	50686772	19	-	27760321	HT29	viability after 16 days	AAGCGGACCGTGTATCAGATGG	SHANK1	ENSG00000161681	0.3435653812890389	[325,254]	[568,339,344]	4	hSpCas9	negative selection	5189905
50687995	50688017	19	-	27760321	HT29	viability after 16 days	GTGAACATGATCCGCCAAGGGG	SHANK1	ENSG00000161681	0.12274471610408472	[314,245]	[396,505,122]	1	hSpCas9	negative selection	5189906
50697617	50697639	19	-	27760321	HT29	viability after 13 days	CTCTTCCGGCATTATACCGTGG	SHANK1	ENSG00000161681	-0.5049935309764063	[386,301]	[267,331,246]	-5	hSpCas9	negative selection	5273365
50704472	50704494	19	-	27760321	HT29	viability after 13 days	CTGTATCGAGGTGCCGACAAGG	SHANK1	ENSG00000161681	0.027109012222394313	[448,350]	[538,313,559]	0	hSpCas9	negative selection	5273366
50712068	50712090	19	-	27760321	HT29	viability after 13 days	CCAACTACAAGGACCGTCGGGG	SHANK1	ENSG00000161681	0.7076382352829462	[559,436]	[1100,926,812]	8	hSpCas9	negative selection	5273367
50686750	50686772	19	-	27760321	HT29	viability after 13 days	AAGCGGACCGTGTATCAGATGG	SHANK1	ENSG00000161681	-0.5545587782336432	[325,254]	[309,280,104]	-6	hSpCas9	negative selection	5273368
50687995	50688017	19	-	27760321	HT29	viability after 13 days	GTGAACATGATCCGCCAAGGGG	SHANK1	ENSG00000161681	-0.1917604211884109	[314,245]	[215,253,378]	-2	hSpCas9	negative selection	5273369
50697617	50697639	19	-	27760321	HT29	viability after 10 days	CTCTTCCGGCATTATACCGTGG	SHANK1	ENSG00000161681	-0.09990606811271409	[386,301]	[434,446,324]	-1	hSpCas9	negative selection	5356828
50704472	50704494	19	-	27760321	HT29	viability after 10 days	CTGTATCGAGGTGCCGACAAGG	SHANK1	ENSG00000161681	0.17443206084307278	[448,350]	[651,465,569]	2	hSpCas9	negative selection	5356829
50712068	50712090	19	-	27760321	HT29	viability after 10 days	CCAACTACAAGGACCGTCGGGG	SHANK1	ENSG00000161681	0.2965014873829664	[559,436]	[532,865,893]	4	hSpCas9	negative selection	5356830
50686750	50686772	19	-	27760321	HT29	viability after 10 days	AAGCGGACCGTGTATCAGATGG	SHANK1	ENSG00000161681	-0.22475802884587182	[325,254]	[332,335,263]	-3	hSpCas9	negative selection	5356831
50687995	50688017	19	-	27760321	HT29	viability after 10 days	GTGAACATGATCCGCCAAGGGG	SHANK1	ENSG00000161681	0.6577655031399965	[314,245]	[416,822,427]	8	hSpCas9	negative selection	5356832
50697617	50697639	19	-	27760321	MOLM13	viability	CTCTTCCGGCATTATACCGTGG	SHANK1	ENSG00000161681	0.5683048705566691	[456,386]	[515,211]	4	hSpCas9	negative selection	5440291
50704472	50704494	19	-	27760321	MOLM13	viability	CTGTATCGAGGTGCCGACAAGG	SHANK1	ENSG00000161681	0.9271033258385027	[491,448]	[732,309]	6	hSpCas9	negative selection	5440292
50712068	50712090	19	-	27760321	MOLM13	viability	CCAACTACAAGGACCGTCGGGG	SHANK1	ENSG00000161681	-0.6288925332272048	[730,559]	[223,241]	-4	hSpCas9	negative selection	5440293
50686750	50686772	19	-	27760321	MOLM13	viability	AAGCGGACCGTGTATCAGATGG	SHANK1	ENSG00000161681	-0.9731902415424292	[365,325]	[128,73]	-5	hSpCas9	negative selection	5440294
50687995	50688017	19	-	27760321	MOLM13	viability	GTGAACATGATCCGCCAAGGGG	SHANK1	ENSG00000161681	-0.4214306167337764	[326,314]	[182,94]	-3	hSpCas9	negative selection	5440295
50719417	50719440	19	+	27661255	K562	viability	GGCTGCTGAGTCCCGGTCGGCGG	SHANK1	ENSG00000161681	-0.06312474595634965	[470,458]	[352,357]	-2	dCas9-KRAB	negative selection	5510853
50719321	50719344	19	-	27661255	K562	viability	GAGGGCGCCCCGGATGTCCTTGG	SHANK1	ENSG00000161681	0.022883059319300347	[1261,1222]	[1198,846]	0	dCas9-KRAB	negative selection	5510854
50716884	50716907	19	+	27260156	BXPC3	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.15692703360078586	[809]	[863,948,932,1044]	3	hSpCas9	negative selection	5570078
50716892	50716915	19	-	27260156	BXPC3	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	-0.019228758207383567	[103]	[132,71,64,163]	0	hSpCas9	negative selection	5570079
50715658	50715681	19	-	27260156	BXPC3	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.26585674282180605	[264]	[227,229,210,253]	-6	hSpCas9	negative selection	5570080
50716443	50716466	19	-	27260156	BXPC3	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	-0.10105347379348184	[1375]	[1242,1210,1293,1665]	-2	hSpCas9	negative selection	5634332
50716367	50716390	19	-	27260156	BXPC3	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.06387580190944009	[610]	[455,576,704,738]	-1	hSpCas9	negative selection	5634333
50715706	50715729	19	+	27260156	BXPC3	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	-0.010068222039977315	[625]	[597,514,788,717]	0	hSpCas9	negative selection	5634334
50716884	50716907	19	+	27260156	A673	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.2115073336090214	[809]	[1206,1187,921,1198]	5	hSpCas9	negative selection	5691329
50716892	50716915	19	-	27260156	A673	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.2556960469751417	[103]	[182,130,130,155]	6	hSpCas9	negative selection	5691330
50715658	50715681	19	-	27260156	A673	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.09676530769936775	[264]	[359,369,252,381]	2	hSpCas9	negative selection	5691331
50716443	50716466	19	-	27260156	A673	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.12233666756335149	[1375]	[2200,1633,1660,1742]	3	hSpCas9	negative selection	5755583
50716367	50716390	19	-	27260156	A673	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.049690642072796554	[610]	[759,656,729,692]	-1	hSpCas9	negative selection	5755584
50715706	50715729	19	+	27260156	A673	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.02812116313014912	[625]	[860,655,674,893]	0	hSpCas9	negative selection	5755585
50716884	50716907	19	+	27260156	A375	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.18788003533290543	[809]	[951,1233,1319,848]	2	hSpCas9	negative selection	5812580
50716892	50716915	19	-	27260156	A375	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.5385542096812042	[103]	[186,197,89,226]	7	hSpCas9	negative selection	5812581
50715658	50715681	19	-	27260156	A375	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.015533661535919951	[264]	[340,491,273,183]	0	hSpCas9	negative selection	5812582
50716443	50716466	19	-	27260156	A375	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	-0.0008525902041403022	[1375]	[1883,1805,1185,1575]	0	hSpCas9	negative selection	5876834
50716367	50716390	19	-	27260156	A375	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.07714978509212322	[610]	[632,809,744,548]	-1	hSpCas9	negative selection	5876835
50715706	50715729	19	+	27260156	A375	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.0471799569356362	[625]	[750,784,823,672]	0	hSpCas9	negative selection	5876836
50716884	50716907	19	+	27260156	COLO741	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	-0.0032249285360911317	[809]	[1285,901,935]	0	hSpCas9	negative selection	5933831
50716892	50716915	19	-	27260156	COLO741	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.3637991611390641	[103]	[223,177,118]	7	hSpCas9	negative selection	5933832
50715658	50715681	19	-	27260156	COLO741	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.21138275054961675	[264]	[512,388,290]	4	hSpCas9	negative selection	5933833
50716443	50716466	19	-	27260156	COLO741	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.04774256344278682	[1375]	[2084,1791,1608]	1	hSpCas9	negative selection	5998085
50716367	50716390	19	-	27260156	COLO741	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.2180049059723481	[610]	[628,769,613]	-5	hSpCas9	negative selection	5998086
50715706	50715729	19	+	27260156	COLO741	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	-0.07619889216926118	[625]	[790,851,642]	-2	hSpCas9	negative selection	5998087
50716884	50716907	19	+	27260156	CAL120	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.29160909916782274	[809]	[1378,1301,1044]	4	hSpCas9	negative selection	6055082
50716892	50716915	19	-	27260156	CAL120	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.304922470063262	[103]	[182,193,106]	4	hSpCas9	negative selection	6055083
50715658	50715681	19	-	27260156	CAL120	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.1627531963824984	[264]	[534,326,271]	2	hSpCas9	negative selection	6055084
50716443	50716466	19	-	27260156	CAL120	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.1312921176559696	[1375]	[2343,1925,1433]	2	hSpCas9	negative selection	6119336
50716367	50716390	19	-	27260156	CAL120	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	0.35520864719460205	[610]	[845,1342,713]	5	hSpCas9	negative selection	6119337
50715706	50715729	19	+	27260156	CAL120	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.4328348590153453	[625]	[1644,743,857]	6	hSpCas9	negative selection	6119338
50716884	50716907	19	+	27260156	CADOES1	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.0749690373183719	[809]	[790,1094,617,665]	1	hSpCas9	negative selection	6176333
50716892	50716915	19	-	27260156	CADOES1	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.4858577527345085	[103]	[171,131,120,115]	7	hSpCas9	negative selection	6176334
50715658	50715681	19	-	27260156	CADOES1	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.2629196117901881	[264]	[247,182,145,245]	-4	hSpCas9	negative selection	6176335
50716443	50716466	19	-	27260156	CADOES1	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	-0.04158979483847358	[1375]	[950,1533,1269,1218]	0	hSpCas9	negative selection	6240587
50716367	50716390	19	-	27260156	CADOES1	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.038019351630348475	[610]	[497,579,585,549]	0	hSpCas9	negative selection	6240588
50715706	50715729	19	+	27260156	CADOES1	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	-0.05987025491890757	[625]	[448,633,608,541]	-1	hSpCas9	negative selection	6240589
50716884	50716907	19	+	27260156	EWS502	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	-0.06314013018892572	[809]	[631,872,859,946]	-1	hSpCas9	negative selection	6297584
50716892	50716915	19	-	27260156	EWS502	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	-0.3529237681074804	[103]	[68,96,68,112]	-6	hSpCas9	negative selection	6297585
50715658	50715681	19	-	27260156	EWS502	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.07732708421461976	[264]	[186,223,306,363]	-1	hSpCas9	negative selection	6297586
50716443	50716466	19	-	27260156	EWS502	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	-0.056466115413011275	[1375]	[1152,1395,1584,1506]	-1	hSpCas9	negative selection	6361838
50716367	50716390	19	-	27260156	EWS502	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.1245974326750306	[610]	[461,535,694,706]	-2	hSpCas9	negative selection	6361839
50715706	50715729	19	+	27260156	EWS502	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.0023087190369722177	[625]	[638,601,814,600]	0	hSpCas9	negative selection	6361840
50716884	50716907	19	+	27260156	EW8	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.1080949208969263	[809]	[669,622,575,975]	2	hSpCas9	negative selection	6418835
50716892	50716915	19	-	27260156	EW8	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	-0.15636608328437918	[103]	[172,47,51,43]	-3	hSpCas9	negative selection	6418836
50715658	50715681	19	-	27260156	EW8	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.21323911632706316	[264]	[254,178,114,210]	-4	hSpCas9	negative selection	6418837
50716443	50716466	19	-	27260156	EW8	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.033167291719073955	[1375]	[1142,1185,963,1297]	0	hSpCas9	negative selection	6483089
50716367	50716390	19	-	27260156	EW8	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.20538327793516792	[610]	[522,400,290,534]	-4	hSpCas9	negative selection	6483090
50715706	50715729	19	+	27260156	EW8	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	-0.10357317793061988	[625]	[596,457,335,532]	-2	hSpCas9	negative selection	6483091
50716884	50716907	19	+	27260156	CORL105	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.1289170036979721	[809]	[1020,947,1130,1062]	2	hSpCas9	negative selection	6540086
50716892	50716915	19	-	27260156	CORL105	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	-0.1004021608880854	[103]	[144,70,112,126]	-2	hSpCas9	negative selection	6540087
50715658	50715681	19	-	27260156	CORL105	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.011639884030054448	[264]	[287,157,448,359]	0	hSpCas9	negative selection	6540088
50716443	50716466	19	-	27260156	CORL105	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.010637653933574631	[1375]	[1723,1799,1655,1316]	0	hSpCas9	negative selection	6604340
50716367	50716390	19	-	27260156	CORL105	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.006992569759302236	[610]	[784,637,642,773]	0	hSpCas9	negative selection	6604341
50715706	50715729	19	+	27260156	CORL105	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.029798174017034607	[625]	[861,784,834,527]	0	hSpCas9	negative selection	6604342
50716884	50716907	19	+	27260156	HS294T	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.39918860833997794	[809]	[399,348,407,513]	5	hSpCas9	negative selection	6661337
50716892	50716915	19	-	27260156	HS294T	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.6631402118276015	[103]	[50,37,101,65]	8	hSpCas9	negative selection	6661338
50715658	50715681	19	-	27260156	HS294T	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.20839250157880762	[264]	[79,73,96,107]	-3	hSpCas9	negative selection	6661339
50716443	50716466	19	-	27260156	HS294T	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.22512301310914906	[1375]	[475,626,676,738]	3	hSpCas9	negative selection	6725591
50716367	50716390	19	-	27260156	HS294T	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.2012593881441937	[610]	[219,284,141,162]	-3	hSpCas9	negative selection	6725592
50715706	50715729	19	+	27260156	HS294T	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.3954814827085424	[625]	[343,430,207,275]	5	hSpCas9	negative selection	6725593
50716884	50716907	19	+	27260156	HCC44	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.20401434471919633	[809]	[1014,865,1176,1193]	3	hSpCas9	negative selection	6782588
50716892	50716915	19	-	27260156	HCC44	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.08485941205595271	[103]	[176,129,135,62]	1	hSpCas9	negative selection	6782589
50715658	50715681	19	-	27260156	HCC44	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.48015734290977824	[264]	[278,421,559,418]	7	hSpCas9	negative selection	6782590
50716443	50716466	19	-	27260156	HCC44	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.2390550423192095	[1375]	[1822,1646,2450,1551]	4	hSpCas9	negative selection	6846842
50716367	50716390	19	-	27260156	HCC44	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.026300292690781435	[610]	[585,361,913,915]	0	hSpCas9	negative selection	6846843
50715706	50715729	19	+	27260156	HCC44	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.5007135289741775	[625]	[1074,964,1318,715]	8	hSpCas9	negative selection	6846844
50716884	50716907	19	+	27260156	G402	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.7096143090347761	[809]	[2158,1706,1193,1488]	8	hSpCas9	negative selection	6903839
50716892	50716915	19	-	27260156	G402	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.4632155547064367	[103]	[194,125,326,56]	6	hSpCas9	negative selection	6903840
50715658	50715681	19	-	27260156	G402	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.10869071755754955	[264]	[467,90,382,269]	-1	hSpCas9	negative selection	6903841
50716443	50716466	19	-	27260156	G402	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	-0.001721870268345027	[1375]	[1834,1551,1779,1555]	0	hSpCas9	negative selection	6968093
50716367	50716390	19	-	27260156	G402	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.07824695128295373	[610]	[489,855,609,836]	-1	hSpCas9	negative selection	6968094
50715706	50715729	19	+	27260156	G402	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	-0.14931910856611214	[625]	[858,781,742,411]	-2	hSpCas9	negative selection	6968095
50716884	50716907	19	+	27260156	L33	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.13079314792501884	[809]	[822,345,604,918]	3	hSpCas9	negative selection	7025090
50716892	50716915	19	-	27260156	L33	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.01987871631149618	[103]	[77,55,40,141]	0	hSpCas9	negative selection	7025091
50715658	50715681	19	-	27260156	L33	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.48955978943465445	[264]	[299,205,211,349]	8	hSpCas9	negative selection	7025092
50716443	50716466	19	-	27260156	L33	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.32609599345396934	[1375]	[1847,731,1087,1532]	7	hSpCas9	negative selection	7089344
50716367	50716390	19	-	27260156	L33	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.0019056855486465074	[610]	[617,250,501,413]	0	hSpCas9	negative selection	7089345
50715706	50715729	19	+	27260156	L33	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.3146572235322826	[625]	[762,284,518,829]	6	hSpCas9	negative selection	7089346
50716884	50716907	19	+	27260156	K562	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	-0.02460287137864592	[809]	[661,531,1128,510]	0	hSpCas9	negative selection	7146341
50716892	50716915	19	-	27260156	K562	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	-0.18767939386786248	[103]	[86,177,26,41]	-2	hSpCas9	negative selection	7146342
50715658	50715681	19	-	27260156	K562	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.16100727912844748	[264]	[296,164,293,101]	-2	hSpCas9	negative selection	7146343
50716443	50716466	19	-	27260156	K562	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.24609053923248148	[1375]	[1476,1721,1095,1501]	3	hSpCas9	negative selection	7210595
50716367	50716390	19	-	27260156	K562	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	0.22608736847105942	[610]	[959,428,337,802]	3	hSpCas9	negative selection	7210596
50715706	50715729	19	+	27260156	K562	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.010682893607419697	[625]	[659,764,456,392]	0	hSpCas9	negative selection	7210597
50716884	50716907	19	+	27260156	HT29	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.06299803422187256	[809]	[1140,1207,861,931]	1	hSpCas9	negative selection	7267592
50716892	50716915	19	-	27260156	HT29	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	-0.022505354935622	[103]	[205,120,96,83]	0	hSpCas9	negative selection	7267593
50715658	50715681	19	-	27260156	HT29	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.057187968008877044	[264]	[373,278,317,361]	1	hSpCas9	negative selection	7267594
50716443	50716466	19	-	27260156	HT29	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	-0.14043957007090313	[1375]	[1717,1605,1365,1405]	-3	hSpCas9	negative selection	7331846
50716367	50716390	19	-	27260156	HT29	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.23732314796776396	[610]	[758,562,586,612]	-5	hSpCas9	negative selection	7331847
50715706	50715729	19	+	27260156	HT29	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	-0.1846518723465807	[625]	[835,748,779,365]	-4	hSpCas9	negative selection	7331848
50716884	50716907	19	+	27260156	MHHES1	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.2764541165556945	[809]	[1222,1062,1227,931]	5	hSpCas9	negative selection	7388843
50716892	50716915	19	-	27260156	MHHES1	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.1465133008491608	[103]	[128,156,101,129]	2	hSpCas9	negative selection	7388844
50715658	50715681	19	-	27260156	MHHES1	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.07320333821976843	[264]	[327,280,275,254]	-1	hSpCas9	negative selection	7388845
50716443	50716466	19	-	27260156	MHHES1	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.2625118092748162	[1375]	[2297,1979,2033,1283]	5	hSpCas9	negative selection	7453097
50716367	50716390	19	-	27260156	MHHES1	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.09056655154680798	[610]	[901,610,608,507]	-2	hSpCas9	negative selection	7453098
50715706	50715729	19	+	27260156	MHHES1	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	-0.12423743341885013	[625]	[828,539,723,520]	-2	hSpCas9	negative selection	7453099
50716884	50716907	19	+	27260156	MEWO	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.15582594698284546	[809]	[1032,659,876]	3	hSpCas9	negative selection	7510094
50716892	50716915	19	-	27260156	MEWO	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.3528255863930101	[103]	[161,134,82]	7	hSpCas9	negative selection	7510095
50715658	50715681	19	-	27260156	MEWO	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.3697623324410262	[264]	[243,359,341]	7	hSpCas9	negative selection	7510096
50716443	50716466	19	-	27260156	MEWO	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.10056898432483319	[1375]	[1741,1296,1171]	2	hSpCas9	negative selection	7574348
50716367	50716390	19	-	27260156	MEWO	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.22366503778074298	[610]	[481,496,487]	-5	hSpCas9	negative selection	7574349
50715706	50715729	19	+	27260156	MEWO	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.003567472409228334	[625]	[655,494,623]	0	hSpCas9	negative selection	7574350
50716884	50716907	19	+	27260156	LNCAPCLONEFGC	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.1384341011489214	[809]	[739,721,982,817]	2	hSpCas9	negative selection	7631345
50716892	50716915	19	-	27260156	LNCAPCLONEFGC	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.4714928733796466	[103]	[106,101,111,200]	7	hSpCas9	negative selection	7631346
50715658	50715681	19	-	27260156	LNCAPCLONEFGC	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.3477259876972482	[264]	[267,312,406,248]	5	hSpCas9	negative selection	7631347
50716443	50716466	19	-	27260156	LNCAPCLONEFGC	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.05651238882432574	[1375]	[1418,1059,1677,1096]	0	hSpCas9	negative selection	7695599
50716367	50716390	19	-	27260156	LNCAPCLONEFGC	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.19837859307991193	[610]	[429,456,543,509]	-3	hSpCas9	negative selection	7695600
50715706	50715729	19	+	27260156	LNCAPCLONEFGC	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.14232775838712103	[625]	[715,497,620,673]	2	hSpCas9	negative selection	7695601
50716884	50716907	19	+	27260156	PANC0327	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.08227995024035417	[809]	[1062,535,903,597]	1	hSpCas9	negative selection	7752596
50716892	50716915	19	-	27260156	PANC0327	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.7224195153702913	[103]	[108,190,96,203]	9	hSpCas9	negative selection	7752597
50715658	50715681	19	-	27260156	PANC0327	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.24304601936986103	[264]	[188,182,290,133]	-4	hSpCas9	negative selection	7752598
50716443	50716466	19	-	27260156	PANC0327	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.18894016022394755	[1375]	[1623,1247,1533,1204]	2	hSpCas9	negative selection	7816850
50716367	50716390	19	-	27260156	PANC0327	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.2749281693467679	[610]	[447,369,348,636]	-4	hSpCas9	negative selection	7816851
50715706	50715729	19	+	27260156	PANC0327	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.06691405918709387	[625]	[533,565,643,583]	1	hSpCas9	negative selection	7816852
50716884	50716907	19	+	27260156	NCIH2009	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.1770603154500967	[809]	[1440,1398,1025]	2	hSpCas9	negative selection	7873847
50716892	50716915	19	-	27260156	NCIH2009	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.7220894551131223	[103]	[288,151,288]	8	hSpCas9	negative selection	7873848
50715658	50715681	19	-	27260156	NCIH2009	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.1908654504169871	[264]	[431,421,414]	2	hSpCas9	negative selection	7873849
50716443	50716466	19	-	27260156	NCIH2009	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.3356818700526707	[1375]	[2773,2041,2533]	4	hSpCas9	negative selection	7938101
50716367	50716390	19	-	27260156	NCIH2009	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.032510120048542424	[610]	[939,907,673]	0	hSpCas9	negative selection	7938102
50715706	50715729	19	+	27260156	NCIH2009	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.44004278055377205	[625]	[1230,878,1461]	6	hSpCas9	negative selection	7938103
50716884	50716907	19	+	27260156	NCIH1373	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.1477551885698063	[809]	[1265,835,893,285]	1	hSpCas9	negative selection	7995098
50716892	50716915	19	-	27260156	NCIH1373	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.3574161260462134	[103]	[98,216,50,57]	3	hSpCas9	negative selection	7995099
50715658	50715681	19	-	27260156	NCIH1373	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.1533649645689117	[264]	[508,244,461,32]	1	hSpCas9	negative selection	7995100
50716443	50716466	19	-	27260156	NCIH1373	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.34069043047156944	[1375]	[2210,1646,1971,538]	3	hSpCas9	negative selection	8059352
50716367	50716390	19	-	27260156	NCIH1373	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	0.07191601461305713	[610]	[905,703,509,208]	0	hSpCas9	negative selection	8059353
50715706	50715729	19	+	27260156	NCIH1373	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.252202746254732	[625]	[1449,707,670,159]	2	hSpCas9	negative selection	8059354
50716884	50716907	19	+	27260156	PATU8902	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.4170608434135984	[809]	[1258,1305,1461,2066]	4	hSpCas9	negative selection	8116349
50716892	50716915	19	-	27260156	PATU8902	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.24651274432150894	[103]	[316,88,226,17]	2	hSpCas9	negative selection	8116350
50715658	50715681	19	-	27260156	PATU8902	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.11939254127125398	[264]	[560,225,307,543]	1	hSpCas9	negative selection	8116351
50716443	50716466	19	-	27260156	PATU8902	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.36978527120795346	[1375]	[2635,3813,1469,2194]	4	hSpCas9	negative selection	8180603
50716367	50716390	19	-	27260156	PATU8902	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	0.10734213454719554	[610]	[856,464,1368,840]	1	hSpCas9	negative selection	8180604
50715706	50715729	19	+	27260156	PATU8902	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.14200011012434904	[625]	[1392,952,658,900]	1	hSpCas9	negative selection	8180605
50716884	50716907	19	+	27260156	PANC1	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.46189170295411663	[809]	[723,1245,1130,806]	7	hSpCas9	negative selection	8237600
50716892	50716915	19	-	27260156	PANC1	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.9409612246813928	[103]	[166,210,180,137]	9	hSpCas9	negative selection	8237601
50715658	50715681	19	-	27260156	PANC1	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.1745500171001514	[264]	[269,215,260,265]	2	hSpCas9	negative selection	8237602
50716443	50716466	19	-	27260156	PANC1	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.22968025005323223	[1375]	[1532,1782,1373,976]	3	hSpCas9	negative selection	8301854
50716367	50716390	19	-	27260156	PANC1	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	0.11240769137980794	[610]	[498,632,695,464]	1	hSpCas9	negative selection	8301855
50715706	50715729	19	+	27260156	PANC1	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.4668506839570807	[625]	[912,912,733,475]	7	hSpCas9	negative selection	8301856
50716884	50716907	19	+	27260156	PANC0813	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.01085712391181548	[809]	[1271,887,845,860]	0	hSpCas9	negative selection	8358851
50716892	50716915	19	-	27260156	PANC0813	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.2325674775852613	[103]	[224,109,149,98]	4	hSpCas9	negative selection	8358852
50715658	50715681	19	-	27260156	PANC0813	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.26533967783058776	[264]	[472,328,313,387]	4	hSpCas9	negative selection	8358853
50716443	50716466	19	-	27260156	PANC0813	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.3003671672822197	[1375]	[1925,2044,1984,1995]	5	hSpCas9	negative selection	8423105
50716367	50716390	19	-	27260156	PANC0813	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.08317566668785292	[610]	[707,696,569,732]	-1	hSpCas9	negative selection	8423106
50715706	50715729	19	+	27260156	PANC0813	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.04419611284690328	[625]	[823,743,669,796]	0	hSpCas9	negative selection	8423107
50716884	50716907	19	+	27260156	RDES	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.13690807182667952	[809]	[972,864,984,1308]	2	hSpCas9	negative selection	8480102
50716892	50716915	19	-	27260156	RDES	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	-0.3741576410169176	[103]	[102,91,87,77]	-6	hSpCas9	negative selection	8480103
50715658	50715681	19	-	27260156	RDES	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.035994730392664764	[264]	[333,205,313,404]	0	hSpCas9	negative selection	8480104
50716443	50716466	19	-	27260156	RDES	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.025460117518389724	[1375]	[1301,1597,1657,1957]	0	hSpCas9	negative selection	8544356
50716367	50716390	19	-	27260156	RDES	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.04245435049124879	[610]	[479,525,923,878]	0	hSpCas9	negative selection	8544357
50715706	50715729	19	+	27260156	RDES	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	-0.0967551469160084	[625]	[463,694,784,795]	-2	hSpCas9	negative selection	8544358
50716884	50716907	19	+	27260156	PC3	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	-0.028637778571121597	[809]	[557,584,1235,998]	0	hSpCas9	negative selection	8601353
50716892	50716915	19	-	27260156	PC3	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	-0.007597406092994863	[103]	[45,123,138,134]	0	hSpCas9	negative selection	8601354
50715658	50715681	19	-	27260156	PC3	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.17993578540984423	[264]	[196,327,582,207]	4	hSpCas9	negative selection	8601355
50716443	50716466	19	-	27260156	PC3	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.15812145851345738	[1375]	[933,1515,2392,1739]	3	hSpCas9	negative selection	8665607
50716367	50716390	19	-	27260156	PC3	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.060463433191133564	[610]	[287,630,1023,647]	-1	hSpCas9	negative selection	8665608
50715706	50715729	19	+	27260156	PC3	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.0375954560966017	[625]	[499,592,944,629]	0	hSpCas9	negative selection	8665609
50716884	50716907	19	+	27260156	PATU8988T	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.035802555003613956	[809]	[1042,677,748,721]	0	hSpCas9	negative selection	8722604
50716892	50716915	19	-	27260156	PATU8988T	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	-0.1413336173399049	[103]	[68,40,116,135]	-2	hSpCas9	negative selection	8722605
50715658	50715681	19	-	27260156	PATU8988T	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.14024948225218814	[264]	[228,95,355,233]	-2	hSpCas9	negative selection	8722606
50716443	50716466	19	-	27260156	PATU8988T	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	-0.02572081521933689	[1375]	[1250,1140,1302,1531]	0	hSpCas9	negative selection	8786858
50716367	50716390	19	-	27260156	PATU8988T	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.17384905335013648	[610]	[475,638,427,565]	-3	hSpCas9	negative selection	8786859
50715706	50715729	19	+	27260156	PATU8988T	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.028926527793361412	[625]	[458,714,496,824]	0	hSpCas9	negative selection	8786860
50716884	50716907	19	+	27260156	T47D	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.2421118659731306	[809]	[1140,1068,1073,1186]	5	hSpCas9	negative selection	8843855
50716892	50716915	19	-	27260156	T47D	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.15432576838499168	[103]	[132,166,81,155]	3	hSpCas9	negative selection	8843856
50715658	50715681	19	-	27260156	T47D	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.04454296396738222	[264]	[375,299,279,319]	0	hSpCas9	negative selection	8843857
50716443	50716466	19	-	27260156	T47D	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.010629811090609786	[1375]	[1615,1471,1664,1720]	0	hSpCas9	negative selection	8908109
50716367	50716390	19	-	27260156	T47D	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	0.07474049069908517	[610]	[766,672,795,768]	1	hSpCas9	negative selection	8908110
50715706	50715729	19	+	27260156	T47D	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.019230365756133183	[625]	[687,664,831,776]	0	hSpCas9	negative selection	8908111
50716884	50716907	19	+	27260156	SU8686	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.12269106773986738	[809]	[744,804,908,1091]	2	hSpCas9	negative selection	8965106
50716892	50716915	19	-	27260156	SU8686	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.3438855907384546	[103]	[80,96,140,229]	6	hSpCas9	negative selection	8965107
50715658	50715681	19	-	27260156	SU8686	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.26952576924293825	[264]	[283,227,414,362]	4	hSpCas9	negative selection	8965108
50716443	50716466	19	-	27260156	SU8686	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.0930819482605485	[1375]	[1369,1404,1343,1751]	1	hSpCas9	negative selection	9029360
50716367	50716390	19	-	27260156	SU8686	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.12232121200861051	[610]	[440,454,567,828]	-2	hSpCas9	negative selection	9029361
50715706	50715729	19	+	27260156	SU8686	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.33532359981122756	[625]	[614,723,778,1083]	5	hSpCas9	negative selection	9029362
50716884	50716907	19	+	27260156	SKES1	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.12456309572289692	[809]	[943,884,884,816]	2	hSpCas9	negative selection	9086357
50716892	50716915	19	-	27260156	SKES1	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.7219919747314343	[103]	[164,158,172,181]	9	hSpCas9	negative selection	9086358
50715658	50715681	19	-	27260156	SKES1	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.42490584690278094	[264]	[492,349,311,287]	8	hSpCas9	negative selection	9086359
50716443	50716466	19	-	27260156	SKES1	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	-0.06183852864861228	[1375]	[1261,1512,1367,1139]	-1	hSpCas9	negative selection	9150611
50716367	50716390	19	-	27260156	SKES1	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	0.027967078323355654	[610]	[700,751,523,539]	0	hSpCas9	negative selection	9150612
50715706	50715729	19	+	27260156	SKES1	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.09748006228393352	[625]	[689,878,505,625]	2	hSpCas9	negative selection	9150613
50716884	50716907	19	+	27260156	TOV112D	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.2677076822333947	[809]	[857,929,1170,925]	5	hSpCas9	negative selection	9207608
50716892	50716915	19	-	27260156	TOV112D	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.5653264495692438	[103]	[174,236,165,62]	8	hSpCas9	negative selection	9207609
50715658	50715681	19	-	27260156	TOV112D	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.14507494015231426	[264]	[494,343,183,182]	3	hSpCas9	negative selection	9207610
50716443	50716466	19	-	27260156	TOV112D	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.09530657484483651	[1375]	[1542,2239,1135,1170]	1	hSpCas9	negative selection	9271862
50716367	50716390	19	-	27260156	TOV112D	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	-0.31105216257570856	[610]	[531,720,301,476]	-6	hSpCas9	negative selection	9271863
50715706	50715729	19	+	27260156	TOV112D	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.00903305948919575	[625]	[601,724,827,394]	0	hSpCas9	negative selection	9271864
50716884	50716907	19	+	27260156	TC71	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.23636043196419465	[809]	[1128,1003,992,959]	6	hSpCas9	negative selection	9328859
50716892	50716915	19	-	27260156	TC71	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.22850922872403157	[103]	[68,199,74,184]	5	hSpCas9	negative selection	9328860
50715658	50715681	19	-	27260156	TC71	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.19887229436202014	[264]	[360,245,318,380]	5	hSpCas9	negative selection	9328861
50716443	50716466	19	-	27260156	TC71	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	-0.03399090639379221	[1375]	[1368,1493,1453,1446]	-1	hSpCas9	negative selection	9393113
50716367	50716390	19	-	27260156	TC71	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	0.025606081463215358	[610]	[695,637,665,665]	0	hSpCas9	negative selection	9393114
50715706	50715729	19	+	27260156	TC71	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	0.2627502419914955	[625]	[700,817,841,863]	6	hSpCas9	negative selection	9393115
50716884	50716907	19	+	27260156	TC32	viability	TTCCTCGTCCTCGCTTGTCGCGG	SHANK1	ENSG00000161681	0.29129945014834824	[809]	[847,583,1525,962]	5	hSpCas9	negative selection	9450110
50716892	50716915	19	-	27260156	TC32	viability	CCACAGCCCCGCGACAAGCGAGG	SHANK1	ENSG00000161681	0.11265720131922041	[103]	[134,51,87,157]	2	hSpCas9	negative selection	9450111
50715658	50715681	19	-	27260156	TC32	viability	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.31800589547458846	[264]	[114,200,319,180]	-5	hSpCas9	negative selection	9450112
50716443	50716466	19	-	27260156	TC32	viability	TCAACCCCGATGCCACCATCTGG	SHANK1	ENSG00000161681	0.011572069493606119	[1375]	[1061,1150,1686,1393]	0	hSpCas9	negative selection	9514364
50716367	50716390	19	-	27260156	TC32	viability	CAACTATGGCCTGTTCCAACCGG	SHANK1	ENSG00000161681	0.03967685036050578	[610]	[632,447,708,603]	0	hSpCas9	negative selection	9514365
50715706	50715729	19	+	27260156	TC32	viability	TGTAAACTCGGGTCTTGTATCGG	SHANK1	ENSG00000161681	-0.047753093343550046	[625]	[539,467,605,681]	-1	hSpCas9	negative selection	9514366
50711970	50711993	19	+	27869803	HPAFII	viability after 27 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	1.5101121288420976	[143]	[171,251,NaN]	9	hSpCas9	negative selection	9569409
50713923	50713946	19	+	27869803	HPAFII	viability after 27 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	0.30748665970118627	[375]	[392,120,NaN]	2	hSpCas9	negative selection	9569410
50714231	50714254	19	-	27869803	HPAFII	viability after 27 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	0.23944816193373508	[190]	[81,148,NaN]	2	hSpCas9	negative selection	9569411
50715658	50715681	19	-	27869803	HPAFII	viability after 27 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.15304598214208598	[377]	[217,145,NaN]	-1	hSpCas9	negative selection	9569412
50716341	50716364	19	+	27869803	HPAFII	viability after 27 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	0.8807862428967624	[93]	[138,50,NaN]	7	hSpCas9	negative selection	9569413
50716886	50716909	19	+	27869803	HPAFII	viability after 27 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	-0.18945896681451568	[41]	[20,17,NaN]	-1	hSpCas9	negative selection	9569414
50711970	50711993	19	+	27869803	HPAFII	viability after 15 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	1.0021675624193769	[143]	[354,281,NaN]	9	hSpCas9	negative selection	9651858
50713923	50713946	19	+	27869803	HPAFII	viability after 15 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	0.23235098608735072	[375]	[618,384,NaN]	2	hSpCas9	negative selection	9651859
50714231	50714254	19	-	27869803	HPAFII	viability after 15 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	0.5748264182154459	[190]	[351,276,NaN]	6	hSpCas9	negative selection	9651860
50715658	50715681	19	-	27869803	HPAFII	viability after 15 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.17164520645953496	[377]	[361,516,NaN]	2	hSpCas9	negative selection	9651861
50716341	50716364	19	+	27869803	HPAFII	viability after 15 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	1.1681874555922773	[93]	[210,236,NaN]	9	hSpCas9	negative selection	9651862
50716886	50716909	19	+	27869803	HPAFII	viability after 15 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	-0.10003489263384013	[41]	[22,53,NaN]	-1	hSpCas9	negative selection	9651863
50711970	50711993	19	+	27869803	ASPC1	viability after 36 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	-0.24505112391362294	[387]	[113,96,126]	-3	hSpCas9	negative selection	9734307
50713923	50713946	19	+	27869803	ASPC1	viability after 36 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	0.6380612846454489	[717]	[176,479,463]	6	hSpCas9	negative selection	9734308
50714231	50714254	19	-	27869803	ASPC1	viability after 36 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	-0.43677395450481254	[499]	[134,112,135]	-4	hSpCas9	negative selection	9734309
50715658	50715681	19	-	27869803	ASPC1	viability after 36 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	0.425412774011802	[1069]	[918,306,357]	4	hSpCas9	negative selection	9734310
50716341	50716364	19	+	27869803	ASPC1	viability after 36 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	-0.6278147041303201	[352]	[90,143,19]	-6	hSpCas9	negative selection	9734311
50716886	50716909	19	+	27869803	ASPC1	viability after 36 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	-0.44955510254115705	[136]	[54,26,26]	-4	hSpCas9	negative selection	9734312
50711970	50711993	19	+	27869803	PATU8988S	viability after 35 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	0.08209909478066546	[360]	[112,194,NaN]	1	hSpCas9	negative selection	9816756
50713923	50713946	19	+	27869803	PATU8988S	viability after 35 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	-0.5201827666263923	[652]	[131,234,NaN]	-5	hSpCas9	negative selection	9816757
50714231	50714254	19	-	27869803	PATU8988S	viability after 35 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	-0.39739041087740107	[479]	[47,245,NaN]	-4	hSpCas9	negative selection	9816758
50715658	50715681	19	-	27869803	PATU8988S	viability after 35 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.3018771205003952	[777]	[332,174,NaN]	-3	hSpCas9	negative selection	9816759
50716341	50716364	19	+	27869803	PATU8988S	viability after 35 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	-0.3004020898973304	[387]	[79,173,NaN]	-3	hSpCas9	negative selection	9816760
50716886	50716909	19	+	27869803	PATU8988S	viability after 35 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	-0.32092303846109926	[89]	[36,20,NaN]	-3	hSpCas9	negative selection	9816761
50711970	50711993	19	+	27869803	PATU8988S	viability after 31 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	-0.4082738632702314	[360]	[45,187,NaN]	-4	hSpCas9	negative selection	9899205
50713923	50713946	19	+	27869803	PATU8988S	viability after 31 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	0.30184538802652444	[652]	[199,474,NaN]	4	hSpCas9	negative selection	9899206
50714231	50714254	19	-	27869803	PATU8988S	viability after 31 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	-0.3283480200684374	[479]	[140,166,NaN]	-4	hSpCas9	negative selection	9899207
50715658	50715681	19	-	27869803	PATU8988S	viability after 31 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.14480660876502505	[777]	[262,302,NaN]	-2	hSpCas9	negative selection	9899208
50716341	50716364	19	+	27869803	PATU8988S	viability after 31 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	0.3116872262423511	[387]	[107,298,NaN]	4	hSpCas9	negative selection	9899209
50716886	50716909	19	+	27869803	PATU8988S	viability after 31 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	-0.03610288793470451	[89]	[34,34,NaN]	0	hSpCas9	negative selection	9899210
50711970	50711993	19	+	27869803	HPAFII	viability after 35 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	1.6827475756971146	[143]	[186,286,NaN]	9	hSpCas9	negative selection	9981654
50713923	50713946	19	+	27869803	HPAFII	viability after 35 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	-0.2642512138049547	[375]	[197,113,NaN]	-2	hSpCas9	negative selection	9981655
50714231	50714254	19	-	27869803	HPAFII	viability after 35 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	0.8696533612246587	[190]	[123,235,NaN]	6	hSpCas9	negative selection	9981656
50715658	50715681	19	-	27869803	HPAFII	viability after 35 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.210069558183911	[377]	[203,121,NaN]	-1	hSpCas9	negative selection	9981657
50716341	50716364	19	+	27869803	HPAFII	viability after 35 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	1.2427247655938267	[93]	[161,56,NaN]	8	hSpCas9	negative selection	9981658
50716886	50716909	19	+	27869803	HPAFII	viability after 35 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	0.06441493651536634	[41]	[17,26,NaN]	0	hSpCas9	negative selection	9981659
50711970	50711993	19	+	27869803	HPAFII	viability after 31 days	TCTCATCAGCTATGCCCAGCTGG	SHANK1	ENSG00000161681	1.4036606360175603	[143]	[164,266,NaN]	9	hSpCas9	negative selection	10064103
50713923	50713946	19	+	27869803	HPAFII	viability after 31 days	TCTGGGCCGCCAGTGTCAAGGGG	SHANK1	ENSG00000161681	-0.14438242570497134	[375]	[244,131,NaN]	-1	hSpCas9	negative selection	10064104
50714231	50714254	19	-	27869803	HPAFII	viability after 31 days	GGACATCTGACAAGGTGGCGCGG	SHANK1	ENSG00000161681	0.47033088447226884	[190]	[103,196,NaN]	3	hSpCas9	negative selection	10064105
50715658	50715681	19	-	27869803	HPAFII	viability after 31 days	GCTGGCCAAGTTGCACACGAAGG	SHANK1	ENSG00000161681	-0.3369832391986787	[377]	[177,156,NaN]	-2	hSpCas9	negative selection	10064106
50716341	50716364	19	+	27869803	HPAFII	viability after 31 days	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	0.4664878929727355	[93]	[103,38,NaN]	3	hSpCas9	negative selection	10064107
50716886	50716909	19	+	27869803	HPAFII	viability after 31 days	CCTCGTCCTCGCTTGTCGCGGGG	SHANK1	ENSG00000161681	0.034151395115332495	[41]	[15,32,NaN]	0	hSpCas9	negative selection	10064108
50716743	50716766	19	+	28162770	P31FUJ	viability	GCCCTGGAGGCCTCTAACAGAGG	SHANK1	ENSG00000161681	-1.0401571264719827	[195]	[111]	-6	hSpCas9	negative selection	10233744
50669174	50669197	19	+	28162770	P31FUJ	viability	GGTGGGGACGTGGTGGGTGGCGG	SHANK1	ENSG00000161681	-1.1113011993666728	[238]	[129]	-7	hSpCas9	negative selection	10233745
50716341	50716364	19	+	28162770	P31FUJ	viability	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	0.7435852383636709	[153]	[302]	8	hSpCas9	negative selection	10233746
50713916	50713939	19	-	28162770	P31FUJ	viability	ACACTGGCGGCCCAGACCGAAGG	SHANK1	ENSG00000161681	0.516212952589892	[309]	[520]	6	hSpCas9	negative selection	10233747
50711460	50711483	19	+	28162770	P31FUJ	viability	GGTGCTGAGAGTGACCCCGCTGG	SHANK1	ENSG00000161681	0.3207961253974425	[61]	[90]	3	hSpCas9	negative selection	10233748
50702503	50702526	19	-	28162770	P31FUJ	viability	GTCCTACCAGGCCCAAGCCGAGG	SHANK1	ENSG00000161681	0.10161683465618043	[114]	[144]	1	hSpCas9	negative selection	10233749
50702481	50702504	19	-	28162770	P31FUJ	viability	GGGGAGATCTCCCTGAGCAAGGG	SHANK1	ENSG00000161681	-0.5698371916919491	[167]	[132]	-5	hSpCas9	negative selection	10233750
50688034	50688057	19	-	28162770	P31FUJ	viability	GAACGGGCAGAATGTGGTGAAGG	SHANK1	ENSG00000161681	0.27257203156891496	[235]	[334]	3	hSpCas9	negative selection	10233751
50688016	50688039	19	-	28162770	P31FUJ	viability	GAAGGTCGGCCACCGACAGGTGG	SHANK1	ENSG00000161681	0.2579164949556172	[310]	[436]	2	hSpCas9	negative selection	10233752
50687997	50688020	19	-	28162770	P31FUJ	viability	GTGGTGAACATGATCCGCCAAGG	SHANK1	ENSG00000161681	0.3150841254323308	[380]	[556]	3	hSpCas9	negative selection	10233753
50716743	50716766	19	+	28162770	TF1	viability	GCCCTGGAGGCCTCTAACAGAGG	SHANK1	ENSG00000161681	NaN	[NaN]	[63]	1	hSpCas9	negative selection	10403110
50669174	50669197	19	+	28162770	TF1	viability	GGTGGGGACGTGGTGGGTGGCGG	SHANK1	ENSG00000161681	NaN	[NaN]	[129]	1	hSpCas9	negative selection	10403111
50716341	50716364	19	+	28162770	TF1	viability	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	NaN	[NaN]	[118]	1	hSpCas9	negative selection	10403112
50713916	50713939	19	-	28162770	TF1	viability	ACACTGGCGGCCCAGACCGAAGG	SHANK1	ENSG00000161681	NaN	[NaN]	[157]	1	hSpCas9	negative selection	10403113
50711460	50711483	19	+	28162770	TF1	viability	GGTGCTGAGAGTGACCCCGCTGG	SHANK1	ENSG00000161681	NaN	[NaN]	[61]	1	hSpCas9	negative selection	10403114
50702503	50702526	19	-	28162770	TF1	viability	GTCCTACCAGGCCCAAGCCGAGG	SHANK1	ENSG00000161681	NaN	[NaN]	[30]	1	hSpCas9	negative selection	10403115
50702481	50702504	19	-	28162770	TF1	viability	GGGGAGATCTCCCTGAGCAAGGG	SHANK1	ENSG00000161681	NaN	[NaN]	[226]	1	hSpCas9	negative selection	10403116
50688034	50688057	19	-	28162770	TF1	viability	GAACGGGCAGAATGTGGTGAAGG	SHANK1	ENSG00000161681	NaN	[NaN]	[399]	1	hSpCas9	negative selection	10403117
50688016	50688039	19	-	28162770	TF1	viability	GAAGGTCGGCCACCGACAGGTGG	SHANK1	ENSG00000161681	NaN	[NaN]	[227]	1	hSpCas9	negative selection	10403118
50687997	50688020	19	-	28162770	TF1	viability	GTGGTGAACATGATCCGCCAAGG	SHANK1	ENSG00000161681	NaN	[NaN]	[314]	1	hSpCas9	negative selection	10403119
50716743	50716766	19	+	28162770	SKM1	viability	GCCCTGGAGGCCTCTAACAGAGG	SHANK1	ENSG00000161681	0.09553614178602143	[35]	[67]	0	hSpCas9	negative selection	10572476
50669174	50669197	19	+	28162770	SKM1	viability	GGTGGGGACGTGGTGGGTGGCGG	SHANK1	ENSG00000161681	-0.10928365010247676	[35]	[58]	-1	hSpCas9	negative selection	10572477
50716341	50716364	19	+	28162770	SKM1	viability	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	0.43433805523778	[53]	[128]	4	hSpCas9	negative selection	10572478
50713916	50713939	19	-	28162770	SKM1	viability	ACACTGGCGGCCCAGACCGAAGG	SHANK1	ENSG00000161681	0.10584851622215918	[81]	[155]	1	hSpCas9	negative selection	10572479
50711460	50711483	19	+	28162770	SKM1	viability	GGTGCTGAGAGTGACCCCGCTGG	SHANK1	ENSG00000161681	-0.48496671074443487	[18]	[23]	-4	hSpCas9	negative selection	10572480
50702503	50702526	19	-	28162770	SKM1	viability	GTCCTACCAGGCCCAAGCCGAGG	SHANK1	ENSG00000161681	-0.07197995103035293	[21]	[36]	0	hSpCas9	negative selection	10572481
50702481	50702504	19	-	28162770	SKM1	viability	GGGGAGATCTCCCTGAGCAAGGG	SHANK1	ENSG00000161681	-0.3000489948266497	[38]	[55]	-3	hSpCas9	negative selection	10572482
50688034	50688057	19	-	28162770	SKM1	viability	GAACGGGCAGAATGTGGTGAAGG	SHANK1	ENSG00000161681	0.42415888924739203	[42]	[101]	4	hSpCas9	negative selection	10572483
50688016	50688039	19	-	28162770	SKM1	viability	GAAGGTCGGCCACCGACAGGTGG	SHANK1	ENSG00000161681	-0.14662390207863085	[66]	[106]	-1	hSpCas9	negative selection	10572484
50687997	50688020	19	-	28162770	SKM1	viability	GTGGTGAACATGATCCGCCAAGG	SHANK1	ENSG00000161681	0.3155018257279293	[89]	[197]	3	hSpCas9	negative selection	10572485
50716743	50716766	19	+	28162770	SKM1	viability	GCCCTGGAGGCCTCTAACAGAGG	SHANK1	ENSG00000161681	0.09553614178602143	[35]	[67]	0	hSpCas9	negative selection	10741842
50669174	50669197	19	+	28162770	SKM1	viability	GGTGGGGACGTGGTGGGTGGCGG	SHANK1	ENSG00000161681	-0.10928365010247676	[35]	[58]	-1	hSpCas9	negative selection	10741843
50716341	50716364	19	+	28162770	SKM1	viability	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	0.43433805523778	[53]	[128]	4	hSpCas9	negative selection	10741844
50713916	50713939	19	-	28162770	SKM1	viability	ACACTGGCGGCCCAGACCGAAGG	SHANK1	ENSG00000161681	0.10584851622215918	[81]	[155]	1	hSpCas9	negative selection	10741845
50711460	50711483	19	+	28162770	SKM1	viability	GGTGCTGAGAGTGACCCCGCTGG	SHANK1	ENSG00000161681	-0.48496671074443487	[18]	[23]	-4	hSpCas9	negative selection	10741846
50702503	50702526	19	-	28162770	SKM1	viability	GTCCTACCAGGCCCAAGCCGAGG	SHANK1	ENSG00000161681	-0.07197995103035293	[21]	[36]	0	hSpCas9	negative selection	10741847
50702481	50702504	19	-	28162770	SKM1	viability	GGGGAGATCTCCCTGAGCAAGGG	SHANK1	ENSG00000161681	-0.3000489948266497	[38]	[55]	-3	hSpCas9	negative selection	10741848
50688034	50688057	19	-	28162770	SKM1	viability	GAACGGGCAGAATGTGGTGAAGG	SHANK1	ENSG00000161681	0.42415888924739203	[42]	[101]	4	hSpCas9	negative selection	10741849
50688016	50688039	19	-	28162770	SKM1	viability	GAAGGTCGGCCACCGACAGGTGG	SHANK1	ENSG00000161681	-0.14662390207863085	[66]	[106]	-1	hSpCas9	negative selection	10741850
50687997	50688020	19	-	28162770	SKM1	viability	GTGGTGAACATGATCCGCCAAGG	SHANK1	ENSG00000161681	0.3155018257279293	[89]	[197]	3	hSpCas9	negative selection	10741851
50716743	50716766	19	+	28162770	PL21	viability	GCCCTGGAGGCCTCTAACAGAGG	SHANK1	ENSG00000161681	-0.7437658234397536	[226]	[58]	-5	hSpCas9	negative selection	10911208
50669174	50669197	19	+	28162770	PL21	viability	GGTGGGGACGTGGTGGGTGGCGG	SHANK1	ENSG00000161681	-0.7409666964571113	[95]	[24]	-5	hSpCas9	negative selection	10911209
50716341	50716364	19	+	28162770	PL21	viability	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	0.5951114907140584	[180]	[118]	5	hSpCas9	negative selection	10911210
50713916	50713939	19	-	28162770	PL21	viability	ACACTGGCGGCCCAGACCGAAGG	SHANK1	ENSG00000161681	0.9110948814157414	[346]	[283]	7	hSpCas9	negative selection	10911211
50711460	50711483	19	+	28162770	PL21	viability	GGTGCTGAGAGTGACCCCGCTGG	SHANK1	ENSG00000161681	0.22359858731330928	[60]	[30]	2	hSpCas9	negative selection	10911212
50702503	50702526	19	-	28162770	PL21	viability	GTCCTACCAGGCCCAAGCCGAGG	SHANK1	ENSG00000161681	-0.7003247119597653	[111]	[29]	-5	hSpCas9	negative selection	10911213
50702481	50702504	19	-	28162770	PL21	viability	GGGGAGATCTCCCTGAGCAAGGG	SHANK1	ENSG00000161681	-0.2183617400930951	[138]	[51]	-1	hSpCas9	negative selection	10911214
50688034	50688057	19	-	28162770	PL21	viability	GAACGGGCAGAATGTGGTGAAGG	SHANK1	ENSG00000161681	-0.5547478876741485	[161]	[47]	-4	hSpCas9	negative selection	10911215
50688016	50688039	19	-	28162770	PL21	viability	GAAGGTCGGCCACCGACAGGTGG	SHANK1	ENSG00000161681	-0.2611915370634586	[189]	[68]	-2	hSpCas9	negative selection	10911216
50687997	50688020	19	-	28162770	PL21	viability	GTGGTGAACATGATCCGCCAAGG	SHANK1	ENSG00000161681	-0.961094426688948	[330]	[73]	-6	hSpCas9	negative selection	10911217
50716743	50716766	19	+	28162770	P31FUJ	viability	GCCCTGGAGGCCTCTAACAGAGG	SHANK1	ENSG00000161681	-1.0401571264719827	[195]	[111]	-6	hSpCas9	negative selection	11080574
50669174	50669197	19	+	28162770	P31FUJ	viability	GGTGGGGACGTGGTGGGTGGCGG	SHANK1	ENSG00000161681	-1.1113011993666728	[238]	[129]	-7	hSpCas9	negative selection	11080575
50716341	50716364	19	+	28162770	P31FUJ	viability	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	0.7435852383636709	[153]	[302]	8	hSpCas9	negative selection	11080576
50713916	50713939	19	-	28162770	P31FUJ	viability	ACACTGGCGGCCCAGACCGAAGG	SHANK1	ENSG00000161681	0.516212952589892	[309]	[520]	6	hSpCas9	negative selection	11080577
50711460	50711483	19	+	28162770	P31FUJ	viability	GGTGCTGAGAGTGACCCCGCTGG	SHANK1	ENSG00000161681	0.3207961253974425	[61]	[90]	3	hSpCas9	negative selection	11080578
50702503	50702526	19	-	28162770	P31FUJ	viability	GTCCTACCAGGCCCAAGCCGAGG	SHANK1	ENSG00000161681	0.10161683465618043	[114]	[144]	1	hSpCas9	negative selection	11080579
50702481	50702504	19	-	28162770	P31FUJ	viability	GGGGAGATCTCCCTGAGCAAGGG	SHANK1	ENSG00000161681	-0.5698371916919491	[167]	[132]	-5	hSpCas9	negative selection	11080580
50688034	50688057	19	-	28162770	P31FUJ	viability	GAACGGGCAGAATGTGGTGAAGG	SHANK1	ENSG00000161681	0.27257203156891496	[235]	[334]	3	hSpCas9	negative selection	11080581
50688016	50688039	19	-	28162770	P31FUJ	viability	GAAGGTCGGCCACCGACAGGTGG	SHANK1	ENSG00000161681	0.2579164949556172	[310]	[436]	2	hSpCas9	negative selection	11080582
50687997	50688020	19	-	28162770	P31FUJ	viability	GTGGTGAACATGATCCGCCAAGG	SHANK1	ENSG00000161681	0.3150841254323308	[380]	[556]	3	hSpCas9	negative selection	11080583
50716743	50716766	19	+	28162770	OCIAML5	viability	GCCCTGGAGGCCTCTAACAGAGG	SHANK1	ENSG00000161681	0.9578305457560603	[80]	[283]	8	hSpCas9	negative selection	11249940
50669174	50669197	19	+	28162770	OCIAML5	viability	GGTGGGGACGTGGTGGGTGGCGG	SHANK1	ENSG00000161681	-1.201651008654225	[78]	[61]	-6	hSpCas9	negative selection	11249941
50716341	50716364	19	+	28162770	OCIAML5	viability	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	0.8584268119410181	[54]	[179]	7	hSpCas9	negative selection	11249942
50713916	50713939	19	-	28162770	OCIAML5	viability	ACACTGGCGGCCCAGACCGAAGG	SHANK1	ENSG00000161681	0.49092313955119504	[135]	[344]	4	hSpCas9	negative selection	11249943
50711460	50711483	19	+	28162770	OCIAML5	viability	GGTGCTGAGAGTGACCCCGCTGG	SHANK1	ENSG00000161681	-0.15162685272290477	[31]	[51]	-1	hSpCas9	negative selection	11249944
50702503	50702526	19	-	28162770	OCIAML5	viability	GTCCTACCAGGCCCAAGCCGAGG	SHANK1	ENSG00000161681	-0.17134508733741027	[67]	[108]	-1	hSpCas9	negative selection	11249945
50702481	50702504	19	-	28162770	OCIAML5	viability	GGGGAGATCTCCCTGAGCAAGGG	SHANK1	ENSG00000161681	0.24873406992349534	[75]	[162]	2	hSpCas9	negative selection	11249946
50688034	50688057	19	-	28162770	OCIAML5	viability	GAACGGGCAGAATGTGGTGAAGG	SHANK1	ENSG00000161681	1.545617361664579	[114]	[605]	9	hSpCas9	negative selection	11249947
50688016	50688039	19	-	28162770	OCIAML5	viability	GAAGGTCGGCCACCGACAGGTGG	SHANK1	ENSG00000161681	0.3499772050806485	[152]	[351]	3	hSpCas9	negative selection	11249948
50687997	50688020	19	-	28162770	OCIAML5	viability	GTGGTGAACATGATCCGCCAAGG	SHANK1	ENSG00000161681	0.044200642041312244	[208]	[388]	0	hSpCas9	negative selection	11249949
50716743	50716766	19	+	28162770	EOL1	viability	GCCCTGGAGGCCTCTAACAGAGG	SHANK1	ENSG00000161681	0.6930531431268342	[370]	[315]	6	hSpCas9	negative selection	11419306
50669174	50669197	19	+	28162770	EOL1	viability	GGTGGGGACGTGGTGGGTGGCGG	SHANK1	ENSG00000161681	0.2279399150204694	[140]	[86]	2	hSpCas9	negative selection	11419307
50716341	50716364	19	+	28162770	EOL1	viability	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	0.3839793902078319	[239]	[164]	3	hSpCas9	negative selection	11419308
50713916	50713939	19	-	28162770	EOL1	viability	ACACTGGCGGCCCAGACCGAAGG	SHANK1	ENSG00000161681	0.6797102037092781	[582]	[491]	6	hSpCas9	negative selection	11419309
50711460	50711483	19	+	28162770	EOL1	viability	GGTGCTGAGAGTGACCCCGCTGG	SHANK1	ENSG00000161681	1.5540289390703355	[116]	[180]	9	hSpCas9	negative selection	11419310
50702503	50702526	19	-	28162770	EOL1	viability	GTCCTACCAGGCCCAAGCCGAGG	SHANK1	ENSG00000161681	-0.41886005072727917	[202]	[79]	-3	hSpCas9	negative selection	11419311
50702481	50702504	19	-	28162770	EOL1	viability	GGGGAGATCTCCCTGAGCAAGGG	SHANK1	ENSG00000161681	-1.0754522284294654	[159]	[39]	-6	hSpCas9	negative selection	11419312
50688034	50688057	19	-	28162770	EOL1	viability	GAACGGGCAGAATGTGGTGAAGG	SHANK1	ENSG00000161681	0.37657947833157984	[230]	[157]	3	hSpCas9	negative selection	11419313
50688016	50688039	19	-	28162770	EOL1	viability	GAAGGTCGGCCACCGACAGGTGG	SHANK1	ENSG00000161681	-0.4176844197719166	[321]	[126]	-3	hSpCas9	negative selection	11419314
50687997	50688020	19	-	28162770	EOL1	viability	GTGGTGAACATGATCCGCCAAGG	SHANK1	ENSG00000161681	-0.7665430800119647	[422]	[130]	-5	hSpCas9	negative selection	11419315
50716743	50716766	19	+	28162770	MOLM13	viability	GCCCTGGAGGCCTCTAACAGAGG	SHANK1	ENSG00000161681	-1.2314511403217099	[327]	[100]	-6	hSpCas9	negative selection	11588672
50669174	50669197	19	+	28162770	MOLM13	viability	GGTGGGGACGTGGTGGGTGGCGG	SHANK1	ENSG00000161681	-2.876640142279916	[192]	[18]	-8	hSpCas9	negative selection	11588673
50716341	50716364	19	+	28162770	MOLM13	viability	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	1.2133165544589812	[169]	[284]	8	hSpCas9	negative selection	11588674
50713916	50713939	19	-	28162770	MOLM13	viability	ACACTGGCGGCCCAGACCGAAGG	SHANK1	ENSG00000161681	0.484842514825776	[422]	[427]	3	hSpCas9	negative selection	11588675
50711460	50711483	19	+	28162770	MOLM13	viability	GGTGCTGAGAGTGACCCCGCTGG	SHANK1	ENSG00000161681	-0.7247556963978172	[63]	[27]	-4	hSpCas9	negative selection	11588676
50702503	50702526	19	-	28162770	MOLM13	viability	GTCCTACCAGGCCCAAGCCGAGG	SHANK1	ENSG00000161681	0.025371145843628096	[158]	[116]	0	hSpCas9	negative selection	11588677
50702481	50702504	19	-	28162770	MOLM13	viability	GGGGAGATCTCCCTGAGCAAGGG	SHANK1	ENSG00000161681	-1.0227457366284243	[221]	[78]	-5	hSpCas9	negative selection	11588678
50688034	50688057	19	-	28162770	MOLM13	viability	GAACGGGCAGAATGTGGTGAAGG	SHANK1	ENSG00000161681	0.2355266714532026	[241]	[205]	1	hSpCas9	negative selection	11588679
50688016	50688039	19	-	28162770	MOLM13	viability	GAAGGTCGGCCACCGACAGGTGG	SHANK1	ENSG00000161681	-0.5549505948135325	[381]	[187]	-3	hSpCas9	negative selection	11588680
50687997	50688020	19	-	28162770	MOLM13	viability	GTGGTGAACATGATCCGCCAAGG	SHANK1	ENSG00000161681	-0.7887472530910644	[539]	[225]	-4	hSpCas9	negative selection	11588681
50716743	50716766	19	+	28162770	HEL	viability	GCCCTGGAGGCCTCTAACAGAGG	SHANK1	ENSG00000161681	-0.5637120454670693	[239]	[103]	-4	hSpCas9	negative selection	11758038
50669174	50669197	19	+	28162770	HEL	viability	GGTGGGGACGTGGTGGGTGGCGG	SHANK1	ENSG00000161681	-0.9325734986870798	[148]	[49]	-5	hSpCas9	negative selection	11758039
50716341	50716364	19	+	28162770	HEL	viability	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	-0.17623517332408056	[186]	[105]	-1	hSpCas9	negative selection	11758040
50713916	50713939	19	-	28162770	HEL	viability	ACACTGGCGGCCCAGACCGAAGG	SHANK1	ENSG00000161681	0.47366222519636525	[424]	[377]	4	hSpCas9	negative selection	11758041
50711460	50711483	19	+	28162770	HEL	viability	GGTGCTGAGAGTGACCCCGCTGG	SHANK1	ENSG00000161681	1.0801441443076552	[47]	[64]	8	hSpCas9	negative selection	11758042
50702503	50702526	19	-	28162770	HEL	viability	GTCCTACCAGGCCCAAGCCGAGG	SHANK1	ENSG00000161681	0.048377633276951215	[153]	[101]	0	hSpCas9	negative selection	11758043
50702481	50702504	19	-	28162770	HEL	viability	GGGGAGATCTCCCTGAGCAAGGG	SHANK1	ENSG00000161681	-0.6341013733584675	[188]	[77]	-4	hSpCas9	negative selection	11758044
50688034	50688057	19	-	28162770	HEL	viability	GAACGGGCAGAATGTGGTGAAGG	SHANK1	ENSG00000161681	0.4225406240768209	[218]	[187]	3	hSpCas9	negative selection	11758045
50688016	50688039	19	-	28162770	HEL	viability	GAAGGTCGGCCACCGACAGGTGG	SHANK1	ENSG00000161681	-0.2539918973879399	[282]	[151]	-2	hSpCas9	negative selection	11758046
50687997	50688020	19	-	28162770	HEL	viability	GTGGTGAACATGATCCGCCAAGG	SHANK1	ENSG00000161681	-0.04068630760648739	[431]	[268]	0	hSpCas9	negative selection	11758047
50716743	50716766	19	+	28162770	MV411	viability	GCCCTGGAGGCCTCTAACAGAGG	SHANK1	ENSG00000161681	-0.7690505720057936	[175]	[86]	-5	hSpCas9	negative selection	11927404
50669174	50669197	19	+	28162770	MV411	viability	GGTGGGGACGTGGTGGGTGGCGG	SHANK1	ENSG00000161681	-0.7086191016296278	[96]	[49]	-5	hSpCas9	negative selection	11927405
50716341	50716364	19	+	28162770	MV411	viability	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	-0.9308996904757373	[171]	[75]	-6	hSpCas9	negative selection	11927406
50713916	50713939	19	-	28162770	MV411	viability	ACACTGGCGGCCCAGACCGAAGG	SHANK1	ENSG00000161681	-0.6050052608033667	[324]	[179]	-4	hSpCas9	negative selection	11927407
50711460	50711483	19	+	28162770	MV411	viability	GGTGCTGAGAGTGACCCCGCTGG	SHANK1	ENSG00000161681	-0.5854524633819662	[56]	[31]	-4	hSpCas9	negative selection	11927408
50702503	50702526	19	-	28162770	MV411	viability	GTCCTACCAGGCCCAAGCCGAGG	SHANK1	ENSG00000161681	-0.21446655353404265	[72]	[52]	-2	hSpCas9	negative selection	11927409
50702481	50702504	19	-	28162770	MV411	viability	GGGGAGATCTCCCTGAGCAAGGG	SHANK1	ENSG00000161681	-0.6221658119615497	[147]	[80]	-4	hSpCas9	negative selection	11927410
50688034	50688057	19	-	28162770	MV411	viability	GAACGGGCAGAATGTGGTGAAGG	SHANK1	ENSG00000161681	0	[183]	[154]	0	hSpCas9	negative selection	11927411
50688016	50688039	19	-	28162770	MV411	viability	GAAGGTCGGCCACCGACAGGTGG	SHANK1	ENSG00000161681	0.06731678223457452	[212]	[187]	0	hSpCas9	negative selection	11927412
50687997	50688020	19	-	28162770	MV411	viability	GTGGTGAACATGATCCGCCAAGG	SHANK1	ENSG00000161681	-0.008341039048219367	[356]	[298]	0	hSpCas9	negative selection	11927413
50716743	50716766	19	+	28162770	MONOMAC1	viability	GCCCTGGAGGCCTCTAACAGAGG	SHANK1	ENSG00000161681	-0.9260755254541311	[120]	[72]	-6	hSpCas9	negative selection	12096770
50669174	50669197	19	+	28162770	MONOMAC1	viability	GGTGGGGACGTGGTGGGTGGCGG	SHANK1	ENSG00000161681	-1.1809171816962767	[88]	[44]	-7	hSpCas9	negative selection	12096771
50716341	50716364	19	+	28162770	MONOMAC1	viability	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	0.33901605318065614	[119]	[173]	3	hSpCas9	negative selection	12096772
50713916	50713939	19	-	28162770	MONOMAC1	viability	ACACTGGCGGCCCAGACCGAAGG	SHANK1	ENSG00000161681	0.29062845230668755	[183]	[257]	3	hSpCas9	negative selection	12096773
50711460	50711483	19	+	28162770	MONOMAC1	viability	GGTGCTGAGAGTGACCCCGCTGG	SHANK1	ENSG00000161681	0.7833343461915135	[36]	[72]	7	hSpCas9	negative selection	12096774
50702503	50702526	19	-	28162770	MONOMAC1	viability	GTCCTACCAGGCCCAAGCCGAGG	SHANK1	ENSG00000161681	-0.5365233133312206	[61]	[48]	-4	hSpCas9	negative selection	12096775
50702481	50702504	19	-	28162770	MONOMAC1	viability	GGGGAGATCTCCCTGAGCAAGGG	SHANK1	ENSG00000161681	0.0774023220464895	[104]	[126]	0	hSpCas9	negative selection	12096776
50688034	50688057	19	-	28162770	MONOMAC1	viability	GAACGGGCAGAATGTGGTGAAGG	SHANK1	ENSG00000161681	0.436599500397292	[135]	[210]	4	hSpCas9	negative selection	12096777
50688016	50688039	19	-	28162770	MONOMAC1	viability	GAAGGTCGGCCACCGACAGGTGG	SHANK1	ENSG00000161681	-0.5596069264442619	[125]	[97]	-5	hSpCas9	negative selection	12096778
50687997	50688020	19	-	28162770	MONOMAC1	viability	GTGGTGAACATGATCCGCCAAGG	SHANK1	ENSG00000161681	0.1998533055090308	[179]	[236]	2	hSpCas9	negative selection	12096779
50716743	50716766	19	+	28162770	OCIAML2	viability	GCCCTGGAGGCCTCTAACAGAGG	SHANK1	ENSG00000161681	0.2883620752540438	[25]	[175]	2	hSpCas9	negative selection	12266136
50669174	50669197	19	+	28162770	OCIAML2	viability	GGTGGGGACGTGGTGGGTGGCGG	SHANK1	ENSG00000161681	-1.2662713267359749	[22]	[52]	-7	hSpCas9	negative selection	12266137
50716341	50716364	19	+	28162770	OCIAML2	viability	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	-0.03005723385617992	[27]	[151]	0	hSpCas9	negative selection	12266138
50713916	50713939	19	-	28162770	OCIAML2	viability	ACACTGGCGGCCCAGACCGAAGG	SHANK1	ENSG00000161681	0.42245497084132677	[69]	[519]	4	hSpCas9	negative selection	12266139
50711460	50711483	19	+	28162770	OCIAML2	viability	GGTGCTGAGAGTGACCCCGCTGG	SHANK1	ENSG00000161681	-0.22777330134599771	[14]	[70]	-2	hSpCas9	negative selection	12266140
50702503	50702526	19	-	28162770	OCIAML2	viability	GTCCTACCAGGCCCAAGCCGAGG	SHANK1	ENSG00000161681	0.1440800188730471	[15]	[97]	1	hSpCas9	negative selection	12266141
50702481	50702504	19	-	28162770	OCIAML2	viability	GGGGAGATCTCCCTGAGCAAGGG	SHANK1	ENSG00000161681	0.19839694026746935	[24]	[158]	2	hSpCas9	negative selection	12266142
50688034	50688057	19	-	28162770	OCIAML2	viability	GAACGGGCAGAATGTGGTGAAGG	SHANK1	ENSG00000161681	0.4475318827013774	[33]	[256]	4	hSpCas9	negative selection	12266143
50688016	50688039	19	-	28162770	OCIAML2	viability	GAAGGTCGGCCACCGACAGGTGG	SHANK1	ENSG00000161681	0.18472200337039296	[29]	[188]	1	hSpCas9	negative selection	12266144
50687997	50688020	19	-	28162770	OCIAML2	viability	GTGGTGAACATGATCCGCCAAGG	SHANK1	ENSG00000161681	0.022410186037955637	[53]	[303]	0	hSpCas9	negative selection	12266145
50716743	50716766	19	+	28162770	OCIAML3	viability	GCCCTGGAGGCCTCTAACAGAGG	SHANK1	ENSG00000161681	-0.029655419278293127	[46]	[138]	0	hSpCas9	negative selection	12435502
50669174	50669197	19	+	28162770	OCIAML3	viability	GGTGGGGACGTGGTGGGTGGCGG	SHANK1	ENSG00000161681	0.133912814239036	[31]	[105]	1	hSpCas9	negative selection	12435503
50716341	50716364	19	+	28162770	OCIAML3	viability	GAAGTTGGCATCGCGGCCGGAGG	SHANK1	ENSG00000161681	0.42125911632914725	[46]	[189]	4	hSpCas9	negative selection	12435504
50713916	50713939	19	-	28162770	OCIAML3	viability	ACACTGGCGGCCCAGACCGAAGG	SHANK1	ENSG00000161681	0.11494357767244656	[77]	[254]	1	hSpCas9	negative selection	12435505
50711460	50711483	19	+	28162770	OCIAML3	viability	GGTGCTGAGAGTGACCCCGCTGG	SHANK1	ENSG00000161681	3.897845456005512	[1]	[89]	9	hSpCas9	negative selection	12435506
50702503	50702526	19	-	28162770	OCIAML3	viability	GTCCTACCAGGCCCAAGCCGAGG	SHANK1	ENSG00000161681	-1.1887511618379045	[36]	[48]	-7	hSpCas9	negative selection	12435507
50702481	50702504	19	-	28162770	OCIAML3	viability	GGGGAGATCTCCCTGAGCAAGGG	SHANK1	ENSG00000161681	0.11452954551552552	[40]	[133]	1	hSpCas9	negative selection	12435508
50688034	50688057	19	-	28162770	OCIAML3	viability	GAACGGGCAGAATGTGGTGAAGG	SHANK1	ENSG00000161681	1.031701202740302	[63]	[394]	8	hSpCas9	negative selection	12435509
50688016	50688039	19	-	28162770	OCIAML3	viability	GAAGGTCGGCCACCGACAGGTGG	SHANK1	ENSG00000161681	0.37624501628178475	[48]	[191]	3	hSpCas9	negative selection	12435510
50687997	50688020	19	-	28162770	OCIAML3	viability	GTGGTGAACATGATCCGCCAAGG	SHANK1	ENSG00000161681	-0.48130750757480095	[79]	[172]	-4	hSpCas9	negative selection	12435511