| 71092515 | 71092538 | 11 | + | 26627737 | DLD1 | viability | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | 0.21669079434560684 | [298] | [118,211,13] | 2 | hSpCas9 | negative selection | 780819 | 71094663 | 71094686 | 11 | + | 26627737 | DLD1 | viability | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | -0.8443730402348757 | [135] | [45,11,13] | -7 | hSpCas9 | negative selection | 780820 | 71109940 | 71109963 | 11 | - | 26627737 | DLD1 | viability | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | 0.21678905232043233 | [233] | [33,106,110] | 2 | hSpCas9 | negative selection | 780821 | 71113347 | 71113370 | 11 | - | 26627737 | DLD1 | viability | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | 0.953943873654327 | [389] | [240,217,246] | 8 | hSpCas9 | negative selection | 780822 | 71118921 | 71118944 | 11 | - | 26627737 | DLD1 | viability | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | -0.7283328076023994 | [422] | [112,68,59] | -6 | hSpCas9 | negative selection | 780823 | 71147299 | 71147322 | 11 | - | 26627737 | DLD1 | viability | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 0.3777860556869137 | [1816] | [640,946,648] | 4 | hSpCas9 | negative selection | 780825 | 71092515 | 71092538 | 11 | + | 26627737 | GBM cells | viability after 5 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | -0.9490830316692644 | [107] | [34,24] | -9 | hSpCas9 | negative selection | 863134 | 71094663 | 71094686 | 11 | + | 26627737 | GBM cells | viability after 5 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | -0.592072477626457 | [103] | [38,34] | -7 | hSpCas9 | negative selection | 863135 | 71109940 | 71109963 | 11 | - | 26627737 | GBM cells | viability after 5 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | -0.0003231481793977975 | [234] | [111,139] | 0 | hSpCas9 | negative selection | 863136 | 71113347 | 71113370 | 11 | - | 26627737 | GBM cells | viability after 5 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | 0.3945454840619836 | [321] | [245,207] | 6 | hSpCas9 | negative selection | 863137 | 71118921 | 71118944 | 11 | - | 26627737 | GBM cells | viability after 5 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | 1.4975513125039184 | [69] | [66,144] | 9 | hSpCas9 | negative selection | 863138 | 71147299 | 71147322 | 11 | - | 26627737 | GBM cells | viability after 5 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 0.05059704482551308 | [901] | [520,480] | 0 | hSpCas9 | negative selection | 863140 | 71092515 | 71092538 | 11 | + | 26627737 | GBM cells | viability after 13 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | -1.1780680260041523 | [107] | [26,24] | -8 | hSpCas9 | negative selection | 945449 | 71094663 | 71094686 | 11 | + | 26627737 | GBM cells | viability after 13 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | -0.1187131112613673 | [103] | [62,42] | -1 | hSpCas9 | negative selection | 945450 | 71109940 | 71109963 | 11 | - | 26627737 | GBM cells | viability after 13 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | -0.16758497390543253 | [234] | [123,104] | -2 | hSpCas9 | negative selection | 945451 | 71113347 | 71113370 | 11 | - | 26627737 | GBM cells | viability after 13 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | 0.44569197350703676 | [321] | [275,206] | 5 | hSpCas9 | negative selection | 945452 | 71118921 | 71118944 | 11 | - | 26627737 | GBM cells | viability after 13 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | 1.5874770469724102 | [69] | [117,110] | 9 | hSpCas9 | negative selection | 945453 | 71147299 | 71147322 | 11 | - | 26627737 | GBM cells | viability after 13 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 0.08252155287428398 | [901] | [606,445] | 1 | hSpCas9 | negative selection | 945455 | 71092515 | 71092538 | 11 | + | 26627737 | GBM cells | viability after 21 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | -1.1197667003843415 | [107] | [26,26] | -7 | hSpCas9 | negative selection | 1027764 | 71094663 | 71094686 | 11 | + | 26627737 | GBM cells | viability after 21 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | -0.2955994098759016 | [103] | [56,35] | -3 | hSpCas9 | negative selection | 1027765 | 71109940 | 71109963 | 11 | - | 26627737 | GBM cells | viability after 21 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | -0.38304669223300863 | [234] | [111,84] | -3 | hSpCas9 | negative selection | 1027766 | 71113347 | 71113370 | 11 | - | 26627737 | GBM cells | viability after 21 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | 0.404461753467007 | [321] | [253,210] | 4 | hSpCas9 | negative selection | 1027767 | 71118921 | 71118944 | 11 | - | 26627737 | GBM cells | viability after 21 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | 1.2435156451421552 | [69] | [88,90] | 9 | hSpCas9 | negative selection | 1027768 | 71147299 | 71147322 | 11 | - | 26627737 | GBM cells | viability after 21 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | -0.2324239598881932 | [901] | [425,408] | -2 | hSpCas9 | negative selection | 1027770 | 71092515 | 71092538 | 11 | + | 26627737 | RPE1 | viability after 9 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | 0.846629248821194 | [252] | [79,222] | 5 | hSpCas9 | negative selection | 1110079 | 71094663 | 71094686 | 11 | + | 26627737 | RPE1 | viability after 9 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | 0.6051955423332367 | [234] | [69,165] | 4 | hSpCas9 | negative selection | 1110080 | 71109940 | 71109963 | 11 | - | 26627737 | RPE1 | viability after 9 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | 1.495974115477279 | [212] | [198,173] | 8 | hSpCas9 | negative selection | 1110081 | 71113347 | 71113370 | 11 | - | 26627737 | RPE1 | viability after 9 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | 0.188502720863584 | [1173] | [372,477] | 1 | hSpCas9 | negative selection | 1110082 | 71118921 | 71118944 | 11 | - | 26627737 | RPE1 | viability after 9 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | 0.6582290832680392 | [557] | [214,353] | 4 | hSpCas9 | negative selection | 1110083 | 71147299 | 71147322 | 11 | - | 26627737 | RPE1 | viability after 9 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 0.9307978860577135 | [2771] | [1587,1739] | 6 | hSpCas9 | negative selection | 1110085 | 71092515 | 71092538 | 11 | + | 26627737 | RPE1 | viability after 12 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | 0.1309024771997318 | [252] | [71,76] | 0 | hSpCas9 | negative selection | 1192394 | 71094663 | 71094686 | 11 | + | 26627737 | RPE1 | viability after 12 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | 0.4563654863342632 | [234] | [73,99] | 3 | hSpCas9 | negative selection | 1192395 | 71109940 | 71109963 | 11 | - | 26627737 | RPE1 | viability after 12 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | 1.2552154648500278 | [212] | [122,150] | 7 | hSpCas9 | negative selection | 1192396 | 71113347 | 71113370 | 11 | - | 26627737 | RPE1 | viability after 12 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | 0.27740219714694236 | [1173] | [408,353] | 1 | hSpCas9 | negative selection | 1192397 | 71118921 | 71118944 | 11 | - | 26627737 | RPE1 | viability after 12 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | 0.943202647146723 | [557] | [245,332] | 6 | hSpCas9 | negative selection | 1192398 | 71147299 | 71147322 | 11 | - | 26627737 | RPE1 | viability after 12 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 1.1439481365161432 | [2771] | [1569,1725] | 6 | hSpCas9 | negative selection | 1192400 | 71092515 | 71092538 | 11 | + | 26627737 | RPE1 | viability after 15 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | 0.42779206140599757 | [252] | [80,110] | 2 | hSpCas9 | negative selection | 1274709 | 71094663 | 71094686 | 11 | + | 26627737 | RPE1 | viability after 15 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | -0.024437987019898078 | [234] | [16,111] | 0 | hSpCas9 | negative selection | 1274710 | 71109940 | 71109963 | 11 | - | 26627737 | RPE1 | viability after 15 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | 1.2547639005872613 | [212] | [127,158] | 7 | hSpCas9 | negative selection | 1274711 | 71113347 | 71113370 | 11 | - | 26627737 | RPE1 | viability after 15 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | 0.03995850453729155 | [1173] | [429,255] | 0 | hSpCas9 | negative selection | 1274712 | 71118921 | 71118944 | 11 | - | 26627737 | RPE1 | viability after 15 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | 0.8152647876035785 | [557] | [94,453] | 5 | hSpCas9 | negative selection | 1274713 | 71147299 | 71147322 | 11 | - | 26627737 | RPE1 | viability after 15 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 1.0608886194537672 | [2771] | [1951,1330] | 6 | hSpCas9 | negative selection | 1274715 | 71092515 | 71092538 | 11 | + | 26627737 | RPE1 | viability after 18 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | -0.16516832578343843 | [252] | [13,110] | -1 | hSpCas9 | negative selection | 1357024 | 71094663 | 71094686 | 11 | + | 26627737 | RPE1 | viability after 18 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | 0.10071470153601925 | [234] | [38,98] | 0 | hSpCas9 | negative selection | 1357025 | 71109940 | 71109963 | 11 | - | 26627737 | RPE1 | viability after 18 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | 1.4837505322743882 | [212] | [182,136] | 7 | hSpCas9 | negative selection | 1357026 | 71113347 | 71113370 | 11 | - | 26627737 | RPE1 | viability after 18 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | 0.08639602844521499 | [1173] | [361,308] | 0 | hSpCas9 | negative selection | 1357027 | 71118921 | 71118944 | 11 | - | 26627737 | RPE1 | viability after 18 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | 0.24446509544479708 | [557] | [116,243] | 1 | hSpCas9 | negative selection | 1357028 | 71147299 | 71147322 | 11 | - | 26627737 | RPE1 | viability after 18 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 1.2460938519406932 | [2771] | [1917,1620] | 7 | hSpCas9 | negative selection | 1357030 | 71092515 | 71092538 | 11 | + | 26627737 | HeLa | viability after 8 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | 0.21049216606266952 | [144] | [133,92,9] | 2 | hSpCas9 | negative selection | 1439339 | 71094663 | 71094686 | 11 | + | 26627737 | HeLa | viability after 8 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | 0.40586814907021185 | [101] | [105,24,55] | 4 | hSpCas9 | negative selection | 1439340 | 71109940 | 71109963 | 11 | - | 26627737 | HeLa | viability after 8 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | 0.8236645868508461 | [189] | [179,54,206] | 6 | hSpCas9 | negative selection | 1439341 | 71113347 | 71113370 | 11 | - | 26627737 | HeLa | viability after 8 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | -0.2658265943899242 | [699] | [371,232,185] | -3 | hSpCas9 | negative selection | 1439342 | 71118921 | 71118944 | 11 | - | 26627737 | HeLa | viability after 8 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | -0.19742516468677418 | [209] | [92,9,134] | -2 | hSpCas9 | negative selection | 1439343 | 71147299 | 71147322 | 11 | - | 26627737 | HeLa | viability after 8 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 0.26989506125673035 | [1582] | [709,849,899] | 2 | hSpCas9 | negative selection | 1439345 | 71092515 | 71092538 | 11 | + | 26627737 | HeLa | viability after 12 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | 0.37296756427377864 | [144] | [77,56,99] | 3 | hSpCas9 | negative selection | 1521654 | 71094663 | 71094686 | 11 | + | 26627737 | HeLa | viability after 12 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | 0.9558779841527927 | [101] | [110,35,103] | 7 | hSpCas9 | negative selection | 1521655 | 71109940 | 71109963 | 11 | - | 26627737 | HeLa | viability after 12 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | 0.3396181939008325 | [189] | [134,24,146] | 3 | hSpCas9 | negative selection | 1521656 | 71113347 | 71113370 | 11 | - | 26627737 | HeLa | viability after 12 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | -0.7236129995059996 | [699] | [194,166,164] | -6 | hSpCas9 | negative selection | 1521657 | 71118921 | 71118944 | 11 | - | 26627737 | HeLa | viability after 12 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | 1.0541716383670974 | [209] | [174,231,127] | 7 | hSpCas9 | negative selection | 1521658 | 71147299 | 71147322 | 11 | - | 26627737 | HeLa | viability after 12 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 0.1284680249303607 | [1582] | [958,728,462] | 1 | hSpCas9 | negative selection | 1521660 | 71092515 | 71092538 | 11 | + | 26627737 | HeLa | viability after 15 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | -0.13181050457916288 | [144] | [53,12,97] | -1 | hSpCas9 | negative selection | 1603969 | 71094663 | 71094686 | 11 | + | 26627737 | HeLa | viability after 15 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | 0.8020332885447836 | [101] | [29,63,127] | 6 | hSpCas9 | negative selection | 1603970 | 71109940 | 71109963 | 11 | - | 26627737 | HeLa | viability after 15 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | 0.32661917911306115 | [189] | [101,54,136] | 2 | hSpCas9 | negative selection | 1603971 | 71113347 | 71113370 | 11 | - | 26627737 | HeLa | viability after 15 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | -0.18741513936016263 | [699] | [254,253,240] | -1 | hSpCas9 | negative selection | 1603972 | 71118921 | 71118944 | 11 | - | 26627737 | HeLa | viability after 15 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | 1.376886544758718 | [209] | [118,427,111] | 8 | hSpCas9 | negative selection | 1603973 | 71147299 | 71147322 | 11 | - | 26627737 | HeLa | viability after 15 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 0.2742245590466452 | [1582] | [893,778,653] | 2 | hSpCas9 | negative selection | 1603975 | 71092515 | 71092538 | 11 | + | 26627737 | HeLa | viability after 18 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | -0.10512748120776405 | [144] | [37,10,97] | -1 | hSpCas9 | negative selection | 1686284 | 71094663 | 71094686 | 11 | + | 26627737 | HeLa | viability after 18 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | 0.7904732154779652 | [101] | [18,52,127] | 6 | hSpCas9 | negative selection | 1686285 | 71109940 | 71109963 | 11 | - | 26627737 | HeLa | viability after 18 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | 0.406400709036547 | [189] | [73,51,136] | 3 | hSpCas9 | negative selection | 1686286 | 71113347 | 71113370 | 11 | - | 26627737 | HeLa | viability after 18 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | -0.1748785966821237 | [699] | [181,201,240] | -1 | hSpCas9 | negative selection | 1686287 | 71118921 | 71118944 | 11 | - | 26627737 | HeLa | viability after 18 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | 1.391639098031599 | [209] | [82,355,111] | 8 | hSpCas9 | negative selection | 1686288 | 71147299 | 71147322 | 11 | - | 26627737 | HeLa | viability after 18 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 0.25788681957175585 | [1582] | [573,655,653] | 2 | hSpCas9 | negative selection | 1686290 | 71092515 | 71092538 | 11 | + | 26627737 | HCT116 | viability after 6 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | 0.1756810440925557 | [325] | [73,48] | 1 | hSpCas9 | negative selection | 1768599 | 71094663 | 71094686 | 11 | + | 26627737 | HCT116 | viability after 6 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | -0.9278437459344141 | [327] | [68,3] | -5 | hSpCas9 | negative selection | 1768600 | 71109940 | 71109963 | 11 | - | 26627737 | HCT116 | viability after 6 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | 0.8900278023318752 | [325] | [103,89] | 5 | hSpCas9 | negative selection | 1768601 | 71113347 | 71113370 | 11 | - | 26627737 | HCT116 | viability after 6 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | -1.9137620598796523 | [971] | [46,36] | -8 | hSpCas9 | negative selection | 1768602 | 71118921 | 71118944 | 11 | - | 26627737 | HCT116 | viability after 6 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | -2.2852902258498995 | [752] | [51,8] | -8 | hSpCas9 | negative selection | 1768603 | 71147299 | 71147322 | 11 | - | 26627737 | HCT116 | viability after 6 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 0.3555447785463839 | [2766] | [1077,268] | 2 | hSpCas9 | negative selection | 1768605 | 71092515 | 71092538 | 11 | + | 26627737 | HCT116 | viability after 8 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | 3.0959985284165716 | [7] | [34,37,39] | 9 | hSpCas9 | negative selection | 1850914 | 71094663 | 71094686 | 11 | + | 26627737 | HCT116 | viability after 8 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | 2.2646490265630987 | [27] | [115,18,87] | 9 | hSpCas9 | negative selection | 1850915 | 71109940 | 71109963 | 11 | - | 26627737 | HCT116 | viability after 8 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | -0.22951223462998838 | [254] | [149,83,125] | -3 | hSpCas9 | negative selection | 1850916 | 71113347 | 71113370 | 11 | - | 26627737 | HCT116 | viability after 8 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | 0.31253771154248255 | [435] | [299,204,388] | 3 | hSpCas9 | negative selection | 1850917 | 71118921 | 71118944 | 11 | - | 26627737 | HCT116 | viability after 8 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | 3.6072824536178114 | [13] | [123,98,59] | 9 | hSpCas9 | negative selection | 1850918 | 71147299 | 71147322 | 11 | - | 26627737 | HCT116 | viability after 8 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 0.2705947715462149 | [1339] | [849,650,1166] | 3 | hSpCas9 | negative selection | 1850920 | 71092515 | 71092538 | 11 | + | 26627737 | HCT116 | viability after 9 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | 1.1337585319963899 | [325] | [209,175] | 7 | hSpCas9 | negative selection | 1933229 | 71094663 | 71094686 | 11 | + | 26627737 | HCT116 | viability after 9 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | -0.1486169322826255 | [327] | [35,112] | -1 | hSpCas9 | negative selection | 1933230 | 71109940 | 71109963 | 11 | - | 26627737 | HCT116 | viability after 9 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | 0.4035588891262323 | [325] | [170,70] | 3 | hSpCas9 | negative selection | 1933231 | 71113347 | 71113370 | 11 | - | 26627737 | HCT116 | viability after 9 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | -1.2120036572613544 | [971] | [63,149] | -7 | hSpCas9 | negative selection | 1933232 | 71118921 | 71118944 | 11 | - | 26627737 | HCT116 | viability after 9 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | -2.2685125716793286 | [752] | [91,1] | -9 | hSpCas9 | negative selection | 1933233 | 71147299 | 71147322 | 11 | - | 26627737 | HCT116 | viability after 9 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 0.00140345756709781 | [2766] | [800,690] | 0 | hSpCas9 | negative selection | 1933235 | 71092515 | 71092538 | 11 | + | 26627737 | HCT116 | viability after 12 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | 4.269261830533965 | [7] | [95,43,100] | 9 | hSpCas9 | negative selection | 2015544 | 71094663 | 71094686 | 11 | + | 26627737 | HCT116 | viability after 12 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | 1.0533379161569165 | [27] | [45,19,23] | 8 | hSpCas9 | negative selection | 2015545 | 71109940 | 71109963 | 11 | - | 26627737 | HCT116 | viability after 12 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | -0.38246401185888557 | [254] | [116,54,133] | -4 | hSpCas9 | negative selection | 2015546 | 71113347 | 71113370 | 11 | - | 26627737 | HCT116 | viability after 12 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | -0.1825027112995139 | [435] | [227,225,149] | -2 | hSpCas9 | negative selection | 2015547 | 71118921 | 71118944 | 11 | - | 26627737 | HCT116 | viability after 12 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | 3.9339766306433517 | [13] | [108,43,182] | 9 | hSpCas9 | negative selection | 2015548 | 71147299 | 71147322 | 11 | - | 26627737 | HCT116 | viability after 12 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 0.11996307942972662 | [1339] | [636,803,866] | 1 | hSpCas9 | negative selection | 2015550 | 71092515 | 71092538 | 11 | + | 26627737 | HCT116 | viability after 15 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | 3.2717606050636316 | [7] | [67,23,43] | 9 | hSpCas9 | negative selection | 2097859 | 71094663 | 71094686 | 11 | + | 26627737 | HCT116 | viability after 15 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | 2.148557830202529 | [27] | [45,25,137] | 9 | hSpCas9 | negative selection | 2097860 | 71109940 | 71109963 | 11 | - | 26627737 | HCT116 | viability after 15 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | -0.5259580590092555 | [254] | [114,111,79] | -5 | hSpCas9 | negative selection | 2097861 | 71113347 | 71113370 | 11 | - | 26627737 | HCT116 | viability after 15 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | 0.06219684731363462 | [435] | [371,186,238] | 0 | hSpCas9 | negative selection | 2097862 | 71118921 | 71118944 | 11 | - | 26627737 | HCT116 | viability after 15 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | 3.152262449880557 | [13] | [19,101,85] | 9 | hSpCas9 | negative selection | 2097863 | 71147299 | 71147322 | 11 | - | 26627737 | HCT116 | viability after 15 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 0.49329396046968776 | [1339] | [1295,672,1303] | 4 | hSpCas9 | negative selection | 2097865 | 71092515 | 71092538 | 11 | + | 26627737 | HCT116 | viability after 18 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | 4.040889229786533 | [7] | [63,11,120] | 9 | hSpCas9 | negative selection | 2180174 | 71094663 | 71094686 | 11 | + | 26627737 | HCT116 | viability after 18 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | 2.3422144007058714 | [27] | [64,0,147] | 9 | hSpCas9 | negative selection | 2180175 | 71109940 | 71109963 | 11 | - | 26627737 | HCT116 | viability after 18 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | -1.059185870760463 | [254] | [73,22,83] | -7 | hSpCas9 | negative selection | 2180176 | 71113347 | 71113370 | 11 | - | 26627737 | HCT116 | viability after 18 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | -0.12200930772219304 | [435] | [238,209,127] | -1 | hSpCas9 | negative selection | 2180177 | 71118921 | 71118944 | 11 | - | 26627737 | HCT116 | viability after 18 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | 3.1887352038819605 | [13] | [35,4,151] | 9 | hSpCas9 | negative selection | 2180178 | 71147299 | 71147322 | 11 | - | 26627737 | HCT116 | viability after 18 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 0.6867410841837835 | [1339] | [918,1061,1150] | 5 | hSpCas9 | negative selection | 2180180 | 71234002 | 71234025 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | ATGCCACTGTACTCCAGCCTGAG | SHANK2 | ENSG00000162105 | -1.9834711090057278 | [190,159] | [9,8] | -9 | dCas9-VP64 | positive selection | 2385585 | 71063032 | 71063055 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GAGAAAGAGAAAGAGAGAGAAAG | SHANK2 | ENSG00000162105 | 0.039126650339510544 | [163,24] | [27,12] | 0 | dCas9-VP64 | positive selection | 2385796 | 70774590 | 70774613 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CAGGAGTGAGCCACCGTGCCTGG | SHANK2 | ENSG00000162105 | -0.21542961903399005 | [276,86] | [54,10] | -1 | dCas9-VP64 | positive selection | 2388514 | 70599746 | 70599769 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TGTGCCATTGCACTCCAGCCCGG | SHANK2 | ENSG00000162105 | -1.8772669929253083 | [207,39] | [9,2] | -9 | dCas9-VP64 | positive selection | 2411651 | 70891376 | 70891399 | 11 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TCCGGAGTAGCTGGGACTACGGG | SHANK2 | ENSG00000162105 | -1.0701889682907664 | [130,53] | [5,12] | -6 | dCas9-VP64 | positive selection | 2415418 | 70950445 | 70950468 | 11 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TGTAATCCCAGCACTTTGGGGGG | SHANK2 | ENSG00000162105 | -1.8840232515636643 | [4,58] | [0,1] | -9 | dCas9-VP64 | positive selection | 2423293 | 70613398 | 70613421 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TTTCACCGTGTTAGCTAGGATGG | SHANK2 | ENSG00000162105 | -0.43622771658323056 | [174,104] | [36,6] | -2 | dCas9-VP64 | positive selection | 2433025 | 70600261 | 70600284 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | ACACAAAAATTAGCCGGGCGCGG | SHANK2 | ENSG00000162105 | -0.8999059485131444 | [15,116] | [8,5] | -5 | dCas9-VP64 | positive selection | 2433128 | 70575473 | 70575496 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TGTGCCACTGCACTCCAGCCAGG | SHANK2 | ENSG00000162105 | -0.41902599900673143 | [34,218] | [4,37] | -2 | dCas9-VP64 | positive selection | 2439585 | 70904783 | 70904806 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CAGGCATGAGCCATCGTGCCCAG | SHANK2 | ENSG00000162105 | -2.3680687732448105 | [443,16] | [15,1] | -9 | dCas9-VP64 | positive selection | 2440267 | 71224916 | 71224939 | 11 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | ATGTGTCTACTCCAATTGCCCGG | SHANK2 | ENSG00000162105 | 1.7358426843436823 | [107,41] | [63,44] | 6 | dCas9-VP64 | positive selection | 2442021 | 71224895 | 71224918 | 11 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GGAAGCAGAAGTTCGATCCCTGG | SHANK2 | ENSG00000162105 | 0.2159840468698037 | [76,110] | [9,38] | 1 | dCas9-VP64 | positive selection | 2442022 | 71224943 | 71224966 | 11 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TGTGCTTTGTGTGAGGAATAGGG | SHANK2 | ENSG00000162105 | -1.0564513258775627 | [327,36] | [29,5] | -6 | dCas9-VP64 | positive selection | 2442023 | 71103873 | 71103896 | 11 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GGAGAGAGAGAGAGAAAGAGGGG | SHANK2 | ENSG00000162105 | -0.15360744684382865 | [2,15] | [0,1] | 0 | dCas9-VP64 | positive selection | 2442967 | 71207252 | 71207275 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TCACTACAACCTCTGCCTCCGGG | SHANK2 | ENSG00000162105 | 0.3736894149735144 | [619,564] | [67,277] | 1 | dCas9-VP64 | positive selection | 2444023 | 71166758 | 71166781 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CAGGCGTGAGCCACCACACCGGG | SHANK2 | ENSG00000162105 | 0.08350517940301261 | [638,11] | [141,1] | 0 | dCas9-VP64 | positive selection | 2447532 | 71195156 | 71195179 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GCTGAGGCGGGAGGATCACAAGG | SHANK2 | ENSG00000162105 | 3.278703021819371 | [41,15] | [74,47] | 8 | dCas9-VP64 | positive selection | 2449184 | 71159749 | 71159772 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TGAGGTGGGTGGATCACTTGAAG | SHANK2 | ENSG00000162105 | 0.9269503688862448 | [9,0] | [1,1] | 4 | dCas9-VP64 | positive selection | 2463085 | 70661981 | 70662004 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | AGGCTCAAGGGGGGCTGGCCAGG | SHANK2 | ENSG00000162105 | 0.6548885999307028 | [88,36] | [18,23] | 3 | dCas9-VP64 | positive selection | 2463319 | 70661931 | 70661954 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GGAAGGAGTCATACATGGTGGGG | SHANK2 | ENSG00000162105 | 3.2976670721638452 | [9,10] | [37,8] | 8 | dCas9-VP64 | positive selection | 2463320 | 70661958 | 70661981 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TGCCTGAGGGATGGCTGAGCTGG | SHANK2 | ENSG00000162105 | -0.025306925266064373 | [6,97] | [6,14] | 0 | dCas9-VP64 | positive selection | 2463321 | 70653253 | 70653276 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GTGAGCCACTGCACCCGGCCTGG | SHANK2 | ENSG00000162105 | 1.1797326428655701 | [26,26] | [14,10] | 4 | dCas9-VP64 | positive selection | 2469518 | 71207276 | 71207299 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TTCAAGTGATTCTCTGGCCTCAG | SHANK2 | ENSG00000162105 | -1.0637446925394851 | [166,163] | [9,24] | -6 | dCas9-VP64 | positive selection | 2471135 | 71138537 | 71138560 | 11 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CAGGCGTGAACCACCGCGCCCGG | SHANK2 | ENSG00000162105 | 0.09960352240682058 | [3,22] | [3,0] | 0 | dCas9-VP64 | positive selection | 2472541 | 71234002 | 71234025 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | ATGCCACTGTACTCCAGCCTGAG | SHANK2 | ENSG00000162105 | -0.49457347436203747 | [225,196] | [51,45] | -5 | dCas9-VP64 | positive selection | 2480840 | 71063032 | 71063055 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GAGAAAGAGAAAGAGAGAGAAAG | SHANK2 | ENSG00000162105 | 1.133413249914112 | [120,136] | [88,94] | 7 | dCas9-VP64 | positive selection | 2481051 | 70774590 | 70774613 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CAGGAGTGAGCCACCGTGCCTGG | SHANK2 | ENSG00000162105 | -0.36417141382431395 | [64,32] | [9,14] | -4 | dCas9-VP64 | positive selection | 2483769 | 70599746 | 70599769 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TGTGCCATTGCACTCCAGCCCGG | SHANK2 | ENSG00000162105 | 1.3157553862059514 | [45,21] | [16,37] | 7 | dCas9-VP64 | positive selection | 2506906 | 70891376 | 70891399 | 11 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TCCGGAGTAGCTGGGACTACGGG | SHANK2 | ENSG00000162105 | -0.20642758050950127 | [20,72] | [9,15] | -2 | dCas9-VP64 | positive selection | 2510673 | 70950445 | 70950468 | 11 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TGTAATCCCAGCACTTTGGGGGG | SHANK2 | ENSG00000162105 | -0.3040415459965904 | [20,19] | [5,3] | -3 | dCas9-VP64 | positive selection | 2518548 | 70613398 | 70613421 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TTTCACCGTGTTAGCTAGGATGG | SHANK2 | ENSG00000162105 | 1.4735482921306557 | [116,143] | [227,15] | 8 | dCas9-VP64 | positive selection | 2528280 | 70600261 | 70600284 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | ACACAAAAATTAGCCGGGCGCGG | SHANK2 | ENSG00000162105 | -0.9472939245344096 | [73,17] | [10,3] | -8 | dCas9-VP64 | positive selection | 2528383 | 70575473 | 70575496 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TGTGCCACTGCACTCCAGCCAGG | SHANK2 | ENSG00000162105 | 0.0771162345407751 | [282,156] | [110,43] | 0 | dCas9-VP64 | positive selection | 2534840 | 70904783 | 70904806 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CAGGCATGAGCCATCGTGCCCAG | SHANK2 | ENSG00000162105 | 0.42142368151358683 | [69,54] | [32,21] | 3 | dCas9-VP64 | positive selection | 2535522 | 71224916 | 71224939 | 11 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | ATGTGTCTACTCCAATTGCCCGG | SHANK2 | ENSG00000162105 | -0.15293252033767424 | [183,257] | [37,89] | -1 | dCas9-VP64 | positive selection | 2537276 | 71224895 | 71224918 | 11 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GGAAGCAGAAGTTCGATCCCTGG | SHANK2 | ENSG00000162105 | 0.9547084618562587 | [103,170] | [97,75] | 6 | dCas9-VP64 | positive selection | 2537277 | 71224943 | 71224966 | 11 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TGTGCTTTGTGTGAGGAATAGGG | SHANK2 | ENSG00000162105 | 0.9369870049941914 | [185,105] | [133,51] | 6 | dCas9-VP64 | positive selection | 2537278 | 71103873 | 71103896 | 11 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GGAGAGAGAGAGAGAAAGAGGGG | SHANK2 | ENSG00000162105 | 6.931899571430513 | [13,25] | [4,1590] | 9 | dCas9-VP64 | positive selection | 2538222 | 71207252 | 71207275 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TCACTACAACCTCTGCCTCCGGG | SHANK2 | ENSG00000162105 | 2.2699980135687987 | [309,268] | [879,61] | 8 | dCas9-VP64 | positive selection | 2539278 | 71166758 | 71166781 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CAGGCGTGAGCCACCACACCGGG | SHANK2 | ENSG00000162105 | -0.14914508695783546 | [201,22] | [49,17] | -1 | dCas9-VP64 | positive selection | 2542787 | 71195156 | 71195179 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GCTGAGGCGGGAGGATCACAAGG | SHANK2 | ENSG00000162105 | 0.5394300049106193 | [35,34] | [25,7] | 4 | dCas9-VP64 | positive selection | 2544439 | 71159749 | 71159772 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TGAGGTGGGTGGATCACTTGAAG | SHANK2 | ENSG00000162105 | -0.7008385215102662 | [31,39] | [9,2] | -6 | dCas9-VP64 | positive selection | 2558340 | 70661981 | 70662004 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | AGGCTCAAGGGGGGCTGGCCAGG | SHANK2 | ENSG00000162105 | 0.4410353034503558 | [9,4] | [4,0] | 3 | dCas9-VP64 | positive selection | 2558574 | 70661931 | 70661954 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GGAAGGAGTCATACATGGTGGGG | SHANK2 | ENSG00000162105 | -0.3973596845501002 | [36,56] | [13,7] | -4 | dCas9-VP64 | positive selection | 2558575 | 70661958 | 70661981 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TGCCTGAGGGATGGCTGAGCTGG | SHANK2 | ENSG00000162105 | 1.7920735470459275 | [59,36] | [100,11] | 8 | dCas9-VP64 | positive selection | 2558576 | 70653253 | 70653276 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GTGAGCCACTGCACCCGGCCTGG | SHANK2 | ENSG00000162105 | 0.8568341606696415 | [42,16] | [22,11] | 6 | dCas9-VP64 | positive selection | 2564773 | 71207276 | 71207299 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TTCAAGTGATTCTCTGGCCTCAG | SHANK2 | ENSG00000162105 | 0.3716256793614804 | [44,130] | [31,40] | 3 | dCas9-VP64 | positive selection | 2566390 | 71138537 | 71138560 | 11 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CAGGCGTGAACCACCGCGCCCGG | SHANK2 | ENSG00000162105 | -0.3804364072538059 | [231,140] | [55,37] | -4 | dCas9-VP64 | positive selection | 2567796 | 71146898 | 71146921 | 11 | + | 27661255 | K562 | viability | GACAGCAACAGCATGATGTGAGG | SHANK2 | ENSG00000162105 | -0.04754813148423942 | [138,217] | [158,117] | -2 | dCas9-KRAB | negative selection | 5510855 | 71147092 | 71147115 | 11 | + | 27661255 | K562 | viability | GAACCAAAGGGCAGACCACGGGG | SHANK2 | ENSG00000162105 | 0.17423874771070869 | [972,1146] | [991,918] | 6 | dCas9-KRAB | negative selection | 5510856 | 71147210 | 71147233 | 11 | + | 27661255 | K562 | viability | GGCCCGGATCGTGTCATAGATGG | SHANK2 | ENSG00000162105 | 0.07511847642400937 | [1014,1153] | [903,915] | 2 | dCas9-KRAB | negative selection | 5510857 | 71147267 | 71147290 | 11 | + | 27661255 | K562 | viability | GGAGTAGTCGGAGAAGCTCTGGG | SHANK2 | ENSG00000162105 | 0.38424400913095846 | [199,267] | [273,215] | 9 | dCas9-KRAB | negative selection | 5510858 | 71147190 | 71147213 | 11 | - | 27661255 | K562 | viability | GCCACTGCGGAGAAGCCGGGCGG | SHANK2 | ENSG00000162105 | -0.30118900037423146 | [517,462] | [397,250] | -7 | dCas9-KRAB | negative selection | 5510859 | 71092515 | 71092538 | 11 | + | 27869803 | HPAFII | viability after 27 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | -0.1788174691333706 | [155] | [108,41,NaN] | -1 | hSpCas9 | negative selection | 9543819 | 71094663 | 71094686 | 11 | + | 27869803 | HPAFII | viability after 27 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | -0.7215123837651682 | [68] | [39,6,NaN] | -5 | hSpCas9 | negative selection | 9543820 | 71109940 | 71109963 | 11 | - | 27869803 | HPAFII | viability after 27 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | 0.08339390339560515 | [164] | [104,80,NaN] | 0 | hSpCas9 | negative selection | 9543821 | 71113347 | 71113370 | 11 | - | 27869803 | HPAFII | viability after 27 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | 0.09188342959235762 | [360] | [204,199,NaN] | 0 | hSpCas9 | negative selection | 9543822 | 71118921 | 71118944 | 11 | - | 27869803 | HPAFII | viability after 27 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | 0.8355199013869357 | [49] | [41,50,NaN] | 6 | hSpCas9 | negative selection | 9543823 | 71147299 | 71147322 | 11 | - | 27869803 | HPAFII | viability after 27 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 0.11534738144264267 | [982] | [675,462,NaN] | 0 | hSpCas9 | negative selection | 9543825 | 71092515 | 71092538 | 11 | + | 27869803 | HPAFII | viability after 15 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | -0.8760185664725111 | [155] | [107,80,NaN] | -7 | hSpCas9 | negative selection | 9626268 | 71094663 | 71094686 | 11 | + | 27869803 | HPAFII | viability after 15 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | 0.2657241930810057 | [68] | [127,64,NaN] | 3 | hSpCas9 | negative selection | 9626269 | 71109940 | 71109963 | 11 | - | 27869803 | HPAFII | viability after 15 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | -0.24273582854732034 | [164] | [176,132,NaN] | -3 | hSpCas9 | negative selection | 9626270 | 71113347 | 71113370 | 11 | - | 27869803 | HPAFII | viability after 15 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | -0.11015152532317513 | [360] | [438,309,NaN] | -1 | hSpCas9 | negative selection | 9626271 | 71118921 | 71118944 | 11 | - | 27869803 | HPAFII | viability after 15 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | 1.0823963576650992 | [49] | [180,71,NaN] | 9 | hSpCas9 | negative selection | 9626272 | 71147299 | 71147322 | 11 | - | 27869803 | HPAFII | viability after 15 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 0.12198171781442291 | [982] | [1005,1238,NaN] | 1 | hSpCas9 | negative selection | 9626274 | 71092515 | 71092538 | 11 | + | 27869803 | ASPC1 | viability after 36 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | -0.508625290463407 | [289] | [146,83,6] | -5 | hSpCas9 | negative selection | 9708717 | 71094663 | 71094686 | 11 | + | 27869803 | ASPC1 | viability after 36 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | 0.049059232493761984 | [153] | [62,96,16] | 0 | hSpCas9 | negative selection | 9708718 | 71109940 | 71109963 | 11 | - | 27869803 | ASPC1 | viability after 36 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | 0.5421300475904499 | [316] | [156,187,140] | 5 | hSpCas9 | negative selection | 9708719 | 71113347 | 71113370 | 11 | - | 27869803 | ASPC1 | viability after 36 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | 0.9874146582516186 | [876] | [373,1164,320] | 8 | hSpCas9 | negative selection | 9708720 | 71118921 | 71118944 | 11 | - | 27869803 | ASPC1 | viability after 36 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | 0.5750195938779956 | [195] | [106,129,74] | 6 | hSpCas9 | negative selection | 9708721 | 71147299 | 71147322 | 11 | - | 27869803 | ASPC1 | viability after 36 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 0.30790776497853556 | [2417] | [1101,1157,903] | 3 | hSpCas9 | negative selection | 9708723 | 71092515 | 71092538 | 11 | + | 27869803 | PATU8988S | viability after 35 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | 0.21798182740389438 | [315] | [159,135,NaN] | 2 | hSpCas9 | negative selection | 9791166 | 71094663 | 71094686 | 11 | + | 27869803 | PATU8988S | viability after 35 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | 1.0831727358941388 | [154] | [27,236,NaN] | 9 | hSpCas9 | negative selection | 9791167 | 71109940 | 71109963 | 11 | - | 27869803 | PATU8988S | viability after 35 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | 0.42595024353630817 | [256] | [163,113,NaN] | 5 | hSpCas9 | negative selection | 9791168 | 71113347 | 71113370 | 11 | - | 27869803 | PATU8988S | viability after 35 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | -0.2691688092009534 | [678] | [192,260,NaN] | -3 | hSpCas9 | negative selection | 9791169 | 71118921 | 71118944 | 11 | - | 27869803 | PATU8988S | viability after 35 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | 0.44637872228701303 | [175] | [134,57,NaN] | 5 | hSpCas9 | negative selection | 9791170 | 71147299 | 71147322 | 11 | - | 27869803 | PATU8988S | viability after 35 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 0.11489559763740731 | [2087] | [977,842,NaN] | 1 | hSpCas9 | negative selection | 9791172 | 71092515 | 71092538 | 11 | + | 27869803 | PATU8988S | viability after 31 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | 0.17769967630303474 | [315] | [138,146,NaN] | 2 | hSpCas9 | negative selection | 9873615 | 71094663 | 71094686 | 11 | + | 27869803 | PATU8988S | viability after 31 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | 1.1270372145337202 | [154] | [79,204,NaN] | 9 | hSpCas9 | negative selection | 9873616 | 71109940 | 71109963 | 11 | - | 27869803 | PATU8988S | viability after 31 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | 0.2000160382806746 | [256] | [100,138,NaN] | 2 | hSpCas9 | negative selection | 9873617 | 71113347 | 71113370 | 11 | - | 27869803 | PATU8988S | viability after 31 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | -0.3943318072943966 | [678] | [183,233,NaN] | -4 | hSpCas9 | negative selection | 9873618 | 71118921 | 71118944 | 11 | - | 27869803 | PATU8988S | viability after 31 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | 0.9209891518727947 | [175] | [120,147,NaN] | 8 | hSpCas9 | negative selection | 9873619 | 71147299 | 71147322 | 11 | - | 27869803 | PATU8988S | viability after 31 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 0.035833451825860285 | [2087] | [633,1132,NaN] | 0 | hSpCas9 | negative selection | 9873621 | 71092515 | 71092538 | 11 | + | 27869803 | HPAFII | viability after 35 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | -0.3918683859976213 | [155] | [86,29,NaN] | -2 | hSpCas9 | negative selection | 9956064 | 71094663 | 71094686 | 11 | + | 27869803 | HPAFII | viability after 35 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | -0.6061006218491425 | [68] | [37,5,NaN] | -4 | hSpCas9 | negative selection | 9956065 | 71109940 | 71109963 | 11 | - | 27869803 | HPAFII | viability after 35 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | 0.09162790676689181 | [164] | [104,70,NaN] | 0 | hSpCas9 | negative selection | 9956066 | 71113347 | 71113370 | 11 | - | 27869803 | HPAFII | viability after 35 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | -0.02080501277094704 | [360] | [221,132,NaN] | 0 | hSpCas9 | negative selection | 9956067 | 71118921 | 71118944 | 11 | - | 27869803 | HPAFII | viability after 35 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | -0.5103348912514338 | [49] | [29,3,NaN] | -3 | hSpCas9 | negative selection | 9956068 | 71147299 | 71147322 | 11 | - | 27869803 | HPAFII | viability after 35 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 0.5260747289603263 | [982] | [749,678,NaN] | 3 | hSpCas9 | negative selection | 9956070 | 71092515 | 71092538 | 11 | + | 27869803 | HPAFII | viability after 31 days | GATGGCTGTGTGATACAGCGGGG | SHANK2 | ENSG00000162105 | -0.6785620912817965 | [155] | [47,61,NaN] | -4 | hSpCas9 | negative selection | 10038513 | 71094663 | 71094686 | 11 | + | 27869803 | HPAFII | viability after 31 days | CTGAGCGGCTAAGGTCAGGGGGG | SHANK2 | ENSG00000162105 | -0.8393341956875644 | [68] | [35,5,NaN] | -5 | hSpCas9 | negative selection | 10038514 | 71109940 | 71109963 | 11 | - | 27869803 | HPAFII | viability after 31 days | TTCCACGACCCGGAGACCGGAGG | SHANK2 | ENSG00000162105 | 0.3554443454808528 | [164] | [128,106,NaN] | 2 | hSpCas9 | negative selection | 10038515 | 71113347 | 71113370 | 11 | - | 27869803 | HPAFII | viability after 31 days | GCCAGTTTCGATACAAGAAGCGG | SHANK2 | ENSG00000162105 | 0.07695927056053542 | [360] | [273,147,NaN] | 0 | hSpCas9 | negative selection | 10038516 | 71118921 | 71118944 | 11 | - | 27869803 | HPAFII | viability after 31 days | GAACTACGGCCTGTTCCAGCCGG | SHANK2 | ENSG00000162105 | 0.5781473858714374 | [49] | [72,7,NaN] | 4 | hSpCas9 | negative selection | 10038517 | 71147299 | 71147322 | 11 | - | 27869803 | HPAFII | viability after 31 days | GCGCAGCCCAACATCCAGCGAGG | SHANK2 | ENSG00000162105 | 0.20968775033949072 | [982] | [670,601,NaN] | 1 | hSpCas9 | negative selection | 10038519 | 70492349 | 70492372 | 11 | - | 28162770 | P31FUJ | viability | CAGCAGCCGGTGCTTCCCGGCGG | SHANK2 | ENSG00000162105 | 0.21998153233466278 | [1225] | [1677] | 2 | hSpCas9 | negative selection | 10233754 | 70487316 | 70487339 | 11 | - | 28162770 | P31FUJ | viability | AGAAAACCCATACTCAGAGGTGG | SHANK2 | ENSG00000162105 | 0.35122134733716237 | [1536] | [2303] | 4 | hSpCas9 | negative selection | 10233755 | 70487159 | 70487182 | 11 | - | 28162770 | P31FUJ | viability | GAGCCGTCCACCAGCAGCAGCGG | SHANK2 | ENSG00000162105 | 0.5241684539249047 | [486] | [822] | 6 | hSpCas9 | negative selection | 10233756 | 70486712 | 70486735 | 11 | - | 28162770 | P31FUJ | viability | GCAGTGCCCTCCGCGAGCAGCGG | SHANK2 | ENSG00000162105 | 0.2766999788679576 | [1595] | [2271] | 3 | hSpCas9 | negative selection | 10233757 | 70486581 | 70486604 | 11 | - | 28162770 | P31FUJ | viability | TCAACAGGGACCCAAAGGGGAGG | SHANK2 | ENSG00000162105 | 0.9235398247550087 | [82] | [184] | 9 | hSpCas9 | negative selection | 10233758 | 70486223 | 70486246 | 11 | - | 28162770 | P31FUJ | viability | GAAGGTGTTTCCGAAACCGAAGG | SHANK2 | ENSG00000162105 | 0.6841697616696298 | [1349] | [2548] | 7 | hSpCas9 | negative selection | 10233759 | 70659872 | 70659895 | 11 | - | 28162770 | P31FUJ | viability | GGAGTCCGTGGATGAAGGTGGGG | SHANK2 | ENSG00000162105 | -0.40994069608926553 | [1202] | [1063] | -4 | hSpCas9 | negative selection | 10233760 | 70502844 | 70502867 | 11 | - | 28162770 | P31FUJ | viability | GAATCACCTGGTCCTTAAGGTGG | SHANK2 | ENSG00000162105 | 0.16490194610319442 | [941] | [1240] | 1 | hSpCas9 | negative selection | 10233761 | 70492374 | 70492397 | 11 | - | 28162770 | P31FUJ | viability | GGGTGGCGACCATCAAGCAGCGG | SHANK2 | ENSG00000162105 | 0.35258845925424076 | [1122] | [1684] | 4 | hSpCas9 | negative selection | 10233762 | 70487576 | 70487599 | 11 | + | 28162770 | P31FUJ | viability | TAAGTGGTTGGGGAAGGTGGTGG | SHANK2 | ENSG00000162105 | -1.2585982052917162 | [789] | [387] | -7 | hSpCas9 | negative selection | 10233763 | 70492349 | 70492372 | 11 | - | 28162770 | TF1 | viability | CAGCAGCCGGTGCTTCCCGGCGG | SHANK2 | ENSG00000162105 | NaN | [NaN] | [116] | 1 | hSpCas9 | negative selection | 10403120 | 70487316 | 70487339 | 11 | - | 28162770 | TF1 | viability | AGAAAACCCATACTCAGAGGTGG | SHANK2 | ENSG00000162105 | NaN | [NaN] | [410] | 1 | hSpCas9 | negative selection | 10403121 | 70487159 | 70487182 | 11 | - | 28162770 | TF1 | viability | GAGCCGTCCACCAGCAGCAGCGG | SHANK2 | ENSG00000162105 | NaN | [NaN] | [97] | 1 | hSpCas9 | negative selection | 10403122 | 70486712 | 70486735 | 11 | - | 28162770 | TF1 | viability | GCAGTGCCCTCCGCGAGCAGCGG | SHANK2 | ENSG00000162105 | NaN | [NaN] | [162] | 1 | hSpCas9 | negative selection | 10403123 | 70486581 | 70486604 | 11 | - | 28162770 | TF1 | viability | TCAACAGGGACCCAAAGGGGAGG | SHANK2 | ENSG00000162105 | NaN | [NaN] | [84] | 1 | hSpCas9 | negative selection | 10403124 | 70486223 | 70486246 | 11 | - | 28162770 | TF1 | viability | GAAGGTGTTTCCGAAACCGAAGG | SHANK2 | ENSG00000162105 | NaN | [NaN] | [489] | 1 | hSpCas9 | negative selection | 10403125 | 70659872 | 70659895 | 11 | - | 28162770 | TF1 | viability | GGAGTCCGTGGATGAAGGTGGGG | SHANK2 | ENSG00000162105 | NaN | [NaN] | [78] | 1 | hSpCas9 | negative selection | 10403126 | 70502844 | 70502867 | 11 | - | 28162770 | TF1 | viability | GAATCACCTGGTCCTTAAGGTGG | SHANK2 | ENSG00000162105 | NaN | [NaN] | [62] | 1 | hSpCas9 | negative selection | 10403127 | 70492374 | 70492397 | 11 | - | 28162770 | TF1 | viability | GGGTGGCGACCATCAAGCAGCGG | SHANK2 | ENSG00000162105 | NaN | [NaN] | [300] | 1 | hSpCas9 | negative selection | 10403128 | 70487576 | 70487599 | 11 | + | 28162770 | TF1 | viability | TAAGTGGTTGGGGAAGGTGGTGG | SHANK2 | ENSG00000162105 | NaN | [NaN] | [72] | 1 | hSpCas9 | negative selection | 10403129 | 70492349 | 70492372 | 11 | - | 28162770 | SKM1 | viability | CAGCAGCCGGTGCTTCCCGGCGG | SHANK2 | ENSG00000162105 | 0.23414138001552837 | [62] | [130] | 2 | hSpCas9 | negative selection | 10572486 | 70487316 | 70487339 | 11 | - | 28162770 | SKM1 | viability | AGAAAACCCATACTCAGAGGTGG | SHANK2 | ENSG00000162105 | 0.18519380338219826 | [99] | [200] | 1 | hSpCas9 | negative selection | 10572487 | 70487159 | 70487182 | 11 | - | 28162770 | SKM1 | viability | GAGCCGTCCACCAGCAGCAGCGG | SHANK2 | ENSG00000162105 | 0.3563355432365069 | [37] | [85] | 3 | hSpCas9 | negative selection | 10572488 | 70486712 | 70486735 | 11 | - | 28162770 | SKM1 | viability | GCAGTGCCCTCCGCGAGCAGCGG | SHANK2 | ENSG00000162105 | 0.4410327078117884 | [114] | [275] | 4 | hSpCas9 | negative selection | 10572489 | 70486581 | 70486604 | 11 | - | 28162770 | SKM1 | viability | TCAACAGGGACCCAAAGGGGAGG | SHANK2 | ENSG00000162105 | 0.7629608026991508 | [3] | [11] | 7 | hSpCas9 | negative selection | 10572490 | 70486223 | 70486246 | 11 | - | 28162770 | SKM1 | viability | GAAGGTGTTTCCGAAACCGAAGG | SHANK2 | ENSG00000162105 | 0.5981067908042603 | [70] | [189] | 6 | hSpCas9 | negative selection | 10572491 | 70659872 | 70659895 | 11 | - | 28162770 | SKM1 | viability | GGAGTCCGTGGATGAAGGTGGGG | SHANK2 | ENSG00000162105 | -0.1187192301120879 | [77] | [126] | -1 | hSpCas9 | negative selection | 10572492 | 70502844 | 70502867 | 11 | - | 28162770 | SKM1 | viability | GAATCACCTGGTCCTTAAGGTGG | SHANK2 | ENSG00000162105 | 0.45697425168081 | [74] | [181] | 4 | hSpCas9 | negative selection | 10572493 | 70492374 | 70492397 | 11 | - | 28162770 | SKM1 | viability | GGGTGGCGACCATCAAGCAGCGG | SHANK2 | ENSG00000162105 | 0.7884958948062882 | [55] | [170] | 7 | hSpCas9 | negative selection | 10572494 | 70487576 | 70487599 | 11 | + | 28162770 | SKM1 | viability | TAAGTGGTTGGGGAAGGTGGTGG | SHANK2 | ENSG00000162105 | -0.8220016980220054 | [47] | [47] | -6 | hSpCas9 | negative selection | 10572495 | 70492349 | 70492372 | 11 | - | 28162770 | SKM1 | viability | CAGCAGCCGGTGCTTCCCGGCGG | SHANK2 | ENSG00000162105 | 0.23414138001552837 | [62] | [130] | 2 | hSpCas9 | negative selection | 10741852 | 70487316 | 70487339 | 11 | - | 28162770 | SKM1 | viability | AGAAAACCCATACTCAGAGGTGG | SHANK2 | ENSG00000162105 | 0.18519380338219826 | [99] | [200] | 1 | hSpCas9 | negative selection | 10741853 | 70487159 | 70487182 | 11 | - | 28162770 | SKM1 | viability | GAGCCGTCCACCAGCAGCAGCGG | SHANK2 | ENSG00000162105 | 0.3563355432365069 | [37] | [85] | 3 | hSpCas9 | negative selection | 10741854 | 70486712 | 70486735 | 11 | - | 28162770 | SKM1 | viability | GCAGTGCCCTCCGCGAGCAGCGG | SHANK2 | ENSG00000162105 | 0.4410327078117884 | [114] | [275] | 4 | hSpCas9 | negative selection | 10741855 | 70486581 | 70486604 | 11 | - | 28162770 | SKM1 | viability | TCAACAGGGACCCAAAGGGGAGG | SHANK2 | ENSG00000162105 | 0.7629608026991508 | [3] | [11] | 7 | hSpCas9 | negative selection | 10741856 | 70486223 | 70486246 | 11 | - | 28162770 | SKM1 | viability | GAAGGTGTTTCCGAAACCGAAGG | SHANK2 | ENSG00000162105 | 0.5981067908042603 | [70] | [189] | 6 | hSpCas9 | negative selection | 10741857 | 70659872 | 70659895 | 11 | - | 28162770 | SKM1 | viability | GGAGTCCGTGGATGAAGGTGGGG | SHANK2 | ENSG00000162105 | -0.1187192301120879 | [77] | [126] | -1 | hSpCas9 | negative selection | 10741858 | 70502844 | 70502867 | 11 | - | 28162770 | SKM1 | viability | GAATCACCTGGTCCTTAAGGTGG | SHANK2 | ENSG00000162105 | 0.45697425168081 | [74] | [181] | 4 | hSpCas9 | negative selection | 10741859 | 70492374 | 70492397 | 11 | - | 28162770 | SKM1 | viability | GGGTGGCGACCATCAAGCAGCGG | SHANK2 | ENSG00000162105 | 0.7884958948062882 | [55] | [170] | 7 | hSpCas9 | negative selection | 10741860 | 70487576 | 70487599 | 11 | + | 28162770 | SKM1 | viability | TAAGTGGTTGGGGAAGGTGGTGG | SHANK2 | ENSG00000162105 | -0.8220016980220054 | [47] | [47] | -6 | hSpCas9 | negative selection | 10741861 | 70492349 | 70492372 | 11 | - | 28162770 | PL21 | viability | CAGCAGCCGGTGCTTCCCGGCGG | SHANK2 | ENSG00000162105 | 0.2831953542168786 | [269] | [142] | 2 | hSpCas9 | negative selection | 10911218 | 70487316 | 70487339 | 11 | - | 28162770 | PL21 | viability | AGAAAACCCATACTCAGAGGTGG | SHANK2 | ENSG00000162105 | 0.8021291267711287 | [364] | [276] | 7 | hSpCas9 | negative selection | 10911219 | 70487159 | 70487182 | 11 | - | 28162770 | PL21 | viability | GAGCCGTCCACCAGCAGCAGCGG | SHANK2 | ENSG00000162105 | 0.18024005705161514 | [145] | [71] | 1 | hSpCas9 | negative selection | 10911220 | 70486712 | 70486735 | 11 | - | 28162770 | PL21 | viability | GCAGTGCCCTCCGCGAGCAGCGG | SHANK2 | ENSG00000162105 | -0.27075111952304115 | [315] | [113] | -2 | hSpCas9 | negative selection | 10911221 | 70486581 | 70486604 | 11 | - | 28162770 | PL21 | viability | TCAACAGGGACCCAAAGGGGAGG | SHANK2 | ENSG00000162105 | -1.2592920041479774 | [10] | [1] | -7 | hSpCas9 | negative selection | 10911222 | 70486223 | 70486246 | 11 | - | 28162770 | PL21 | viability | GAAGGTGTTTCCGAAACCGAAGG | SHANK2 | ENSG00000162105 | -0.19413932462272626 | [275] | [104] | -1 | hSpCas9 | negative selection | 10911223 | 70659872 | 70659895 | 11 | - | 28162770 | PL21 | viability | GGAGTCCGTGGATGAAGGTGGGG | SHANK2 | ENSG00000162105 | -0.4329901686923459 | [334] | [107] | -3 | hSpCas9 | negative selection | 10911224 | 70502844 | 70502867 | 11 | - | 28162770 | PL21 | viability | GAATCACCTGGTCCTTAAGGTGG | SHANK2 | ENSG00000162105 | -2.024491279043127 | [214] | [22] | -8 | hSpCas9 | negative selection | 10911225 | 70492374 | 70492397 | 11 | - | 28162770 | PL21 | viability | GGGTGGCGACCATCAAGCAGCGG | SHANK2 | ENSG00000162105 | 0.8240962468263399 | [291] | [224] | 7 | hSpCas9 | negative selection | 10911226 | 70487576 | 70487599 | 11 | + | 28162770 | PL21 | viability | TAAGTGGTTGGGGAAGGTGGTGG | SHANK2 | ENSG00000162105 | 0.9552877426205985 | [204] | [172] | 7 | hSpCas9 | negative selection | 10911227 | 70492349 | 70492372 | 11 | - | 28162770 | P31FUJ | viability | CAGCAGCCGGTGCTTCCCGGCGG | SHANK2 | ENSG00000162105 | 0.21998153233466278 | [1225] | [1677] | 2 | hSpCas9 | negative selection | 11080584 | 70487316 | 70487339 | 11 | - | 28162770 | P31FUJ | viability | AGAAAACCCATACTCAGAGGTGG | SHANK2 | ENSG00000162105 | 0.35122134733716237 | [1536] | [2303] | 4 | hSpCas9 | negative selection | 11080585 | 70487159 | 70487182 | 11 | - | 28162770 | P31FUJ | viability | GAGCCGTCCACCAGCAGCAGCGG | SHANK2 | ENSG00000162105 | 0.5241684539249047 | [486] | [822] | 6 | hSpCas9 | negative selection | 11080586 | 70486712 | 70486735 | 11 | - | 28162770 | P31FUJ | viability | GCAGTGCCCTCCGCGAGCAGCGG | SHANK2 | ENSG00000162105 | 0.2766999788679576 | [1595] | [2271] | 3 | hSpCas9 | negative selection | 11080587 | 70486581 | 70486604 | 11 | - | 28162770 | P31FUJ | viability | TCAACAGGGACCCAAAGGGGAGG | SHANK2 | ENSG00000162105 | 0.9235398247550087 | [82] | [184] | 9 | hSpCas9 | negative selection | 11080588 | 70486223 | 70486246 | 11 | - | 28162770 | P31FUJ | viability | GAAGGTGTTTCCGAAACCGAAGG | SHANK2 | ENSG00000162105 | 0.6841697616696298 | [1349] | [2548] | 7 | hSpCas9 | negative selection | 11080589 | 70659872 | 70659895 | 11 | - | 28162770 | P31FUJ | viability | GGAGTCCGTGGATGAAGGTGGGG | SHANK2 | ENSG00000162105 | -0.40994069608926553 | [1202] | [1063] | -4 | hSpCas9 | negative selection | 11080590 | 70502844 | 70502867 | 11 | - | 28162770 | P31FUJ | viability | GAATCACCTGGTCCTTAAGGTGG | SHANK2 | ENSG00000162105 | 0.16490194610319442 | [941] | [1240] | 1 | hSpCas9 | negative selection | 11080591 | 70492374 | 70492397 | 11 | - | 28162770 | P31FUJ | viability | GGGTGGCGACCATCAAGCAGCGG | SHANK2 | ENSG00000162105 | 0.35258845925424076 | [1122] | [1684] | 4 | hSpCas9 | negative selection | 11080592 | 70487576 | 70487599 | 11 | + | 28162770 | P31FUJ | viability | TAAGTGGTTGGGGAAGGTGGTGG | SHANK2 | ENSG00000162105 | -1.2585982052917162 | [789] | [387] | -7 | hSpCas9 | negative selection | 11080593 | 70492349 | 70492372 | 11 | - | 28162770 | OCIAML5 | viability | CAGCAGCCGGTGCTTCCCGGCGG | SHANK2 | ENSG00000162105 | -0.2889871880412907 | [154] | [228] | -2 | hSpCas9 | negative selection | 11249950 | 70487316 | 70487339 | 11 | - | 28162770 | OCIAML5 | viability | AGAAAACCCATACTCAGAGGTGG | SHANK2 | ENSG00000162105 | 0.6504337696651862 | [167] | [475] | 5 | hSpCas9 | negative selection | 11249951 | 70487159 | 70487182 | 11 | - | 28162770 | OCIAML5 | viability | GAGCCGTCCACCAGCAGCAGCGG | SHANK2 | ENSG00000162105 | 2.589368618479454 | [21] | [238] | 9 | hSpCas9 | negative selection | 11249952 | 70486712 | 70486735 | 11 | - | 28162770 | OCIAML5 | viability | GCAGTGCCCTCCGCGAGCAGCGG | SHANK2 | ENSG00000162105 | 0.15260991634547622 | [153] | [308] | 1 | hSpCas9 | negative selection | 11249953 | 70486581 | 70486604 | 11 | - | 28162770 | OCIAML5 | viability | TCAACAGGGACCCAAAGGGGAGG | SHANK2 | ENSG00000162105 | -1.5301384759766345 | [7] | [4] | -7 | hSpCas9 | negative selection | 11249954 | 70486223 | 70486246 | 11 | - | 28162770 | OCIAML5 | viability | GAAGGTGTTTCCGAAACCGAAGG | SHANK2 | ENSG00000162105 | 0.3357686284360826 | [168] | [384] | 3 | hSpCas9 | negative selection | 11249955 | 70659872 | 70659895 | 11 | - | 28162770 | OCIAML5 | viability | GGAGTCCGTGGATGAAGGTGGGG | SHANK2 | ENSG00000162105 | -1.0711838601675838 | [219] | [188] | -6 | hSpCas9 | negative selection | 11249956 | 70502844 | 70502867 | 11 | - | 28162770 | OCIAML5 | viability | GAATCACCTGGTCCTTAAGGTGG | SHANK2 | ENSG00000162105 | -0.20275365873278317 | [189] | [297] | -1 | hSpCas9 | negative selection | 11249957 | 70492374 | 70492397 | 11 | - | 28162770 | OCIAML5 | viability | GGGTGGCGACCATCAAGCAGCGG | SHANK2 | ENSG00000162105 | 0.07393284769222633 | [129] | [246] | 0 | hSpCas9 | negative selection | 11249958 | 70487576 | 70487599 | 11 | + | 28162770 | OCIAML5 | viability | TAAGTGGTTGGGGAAGGTGGTGG | SHANK2 | ENSG00000162105 | -2.3610802183518547 | [73] | [25] | -8 | hSpCas9 | negative selection | 11249959 | 70492349 | 70492372 | 11 | - | 28162770 | EOL1 | viability | CAGCAGCCGGTGCTTCCCGGCGG | SHANK2 | ENSG00000162105 | 0.5434576042150283 | [391] | [300] | 5 | hSpCas9 | negative selection | 11419316 | 70487316 | 70487339 | 11 | - | 28162770 | EOL1 | viability | AGAAAACCCATACTCAGAGGTGG | SHANK2 | ENSG00000162105 | -0.2066967617077181 | [597] | [272] | -1 | hSpCas9 | negative selection | 11419317 | 70487159 | 70487182 | 11 | - | 28162770 | EOL1 | viability | GAGCCGTCCACCAGCAGCAGCGG | SHANK2 | ENSG00000162105 | 0.4720355668730277 | [155] | [113] | 4 | hSpCas9 | negative selection | 11419318 | 70486712 | 70486735 | 11 | - | 28162770 | EOL1 | viability | GCAGTGCCCTCCGCGAGCAGCGG | SHANK2 | ENSG00000162105 | 0.14156085624820847 | [498] | [289] | 1 | hSpCas9 | negative selection | 11419319 | 70486581 | 70486604 | 11 | - | 28162770 | EOL1 | viability | TCAACAGGGACCCAAAGGGGAGG | SHANK2 | ENSG00000162105 | -0.49048972770830934 | [23] | [8] | -4 | hSpCas9 | negative selection | 11419320 | 70486223 | 70486246 | 11 | - | 28162770 | EOL1 | viability | GAAGGTGTTTCCGAAACCGAAGG | SHANK2 | ENSG00000162105 | 0.6573255687733071 | [413] | [343] | 6 | hSpCas9 | negative selection | 11419321 | 70659872 | 70659895 | 11 | - | 28162770 | EOL1 | viability | GGAGTCCGTGGATGAAGGTGGGG | SHANK2 | ENSG00000162105 | 0.551993603613204 | [434] | [335] | 5 | hSpCas9 | negative selection | 11419322 | 70502844 | 70502867 | 11 | - | 28162770 | EOL1 | viability | GAATCACCTGGTCCTTAAGGTGG | SHANK2 | ENSG00000162105 | 0.33743038614570425 | [334] | [222] | 3 | hSpCas9 | negative selection | 11419323 | 70492374 | 70492397 | 11 | - | 28162770 | EOL1 | viability | GGGTGGCGACCATCAAGCAGCGG | SHANK2 | ENSG00000162105 | 0.47484510045985207 | [350] | [256] | 4 | hSpCas9 | negative selection | 11419324 | 70487576 | 70487599 | 11 | + | 28162770 | EOL1 | viability | TAAGTGGTTGGGGAAGGTGGTGG | SHANK2 | ENSG00000162105 | -0.12840110837842456 | [221] | [106] | -1 | hSpCas9 | negative selection | 11419325 | 70492349 | 70492372 | 11 | - | 28162770 | MOLM13 | viability | CAGCAGCCGGTGCTTCCCGGCGG | SHANK2 | ENSG00000162105 | 0.4487805585968744 | [379] | [374] | 3 | hSpCas9 | negative selection | 11588682 | 70487316 | 70487339 | 11 | - | 28162770 | MOLM13 | viability | AGAAAACCCATACTCAGAGGTGG | SHANK2 | ENSG00000162105 | -0.4358129364328921 | [564] | [301] | -3 | hSpCas9 | negative selection | 11588683 | 70487159 | 70487182 | 11 | - | 28162770 | MOLM13 | viability | GAGCCGTCCACCAGCAGCAGCGG | SHANK2 | ENSG00000162105 | -0.6145727786473941 | [179] | [84] | -4 | hSpCas9 | negative selection | 11588684 | 70486712 | 70486735 | 11 | - | 28162770 | MOLM13 | viability | GCAGTGCCCTCCGCGAGCAGCGG | SHANK2 | ENSG00000162105 | 0.33882680849046665 | [408] | [373] | 2 | hSpCas9 | negative selection | 11588685 | 70486581 | 70486604 | 11 | - | 28162770 | MOLM13 | viability | TCAACAGGGACCCAAAGGGGAGG | SHANK2 | ENSG00000162105 | -2.854038713342784 | [9] | [0] | -8 | hSpCas9 | negative selection | 11588686 | 70486223 | 70486246 | 11 | - | 28162770 | MOLM13 | viability | GAAGGTGTTTCCGAAACCGAAGG | SHANK2 | ENSG00000162105 | -0.056637265314603336 | [373] | [259] | 0 | hSpCas9 | negative selection | 11588687 | 70659872 | 70659895 | 11 | - | 28162770 | MOLM13 | viability | GGAGTCCGTGGATGAAGGTGGGG | SHANK2 | ENSG00000162105 | -1.674489293012071 | [414] | [93] | -7 | hSpCas9 | negative selection | 11588688 | 70502844 | 70502867 | 11 | - | 28162770 | MOLM13 | viability | GAATCACCTGGTCCTTAAGGTGG | SHANK2 | ENSG00000162105 | -0.052017235588220086 | [270] | [188] | 0 | hSpCas9 | negative selection | 11588689 | 70492374 | 70492397 | 11 | - | 28162770 | MOLM13 | viability | GGGTGGCGACCATCAAGCAGCGG | SHANK2 | ENSG00000162105 | 0.296367595167937 | [338] | [300] | 2 | hSpCas9 | negative selection | 11588690 | 70487576 | 70487599 | 11 | + | 28162770 | MOLM13 | viability | TAAGTGGTTGGGGAAGGTGGTGG | SHANK2 | ENSG00000162105 | -1.1307480560736538 | [211] | [69] | -5 | hSpCas9 | negative selection | 11588691 | 70492349 | 70492372 | 11 | - | 28162770 | HEL | viability | CAGCAGCCGGTGCTTCCCGGCGG | SHANK2 | ENSG00000162105 | 1.0505736451208472 | [250] | [332] | 8 | hSpCas9 | negative selection | 11758048 | 70487316 | 70487339 | 11 | - | 28162770 | HEL | viability | AGAAAACCCATACTCAGAGGTGG | SHANK2 | ENSG00000162105 | -0.14688571143841256 | [464] | [268] | -1 | hSpCas9 | negative selection | 11758049 | 70487159 | 70487182 | 11 | - | 28162770 | HEL | viability | GAGCCGTCCACCAGCAGCAGCGG | SHANK2 | ENSG00000162105 | 0.611932785219182 | [141] | [138] | 5 | hSpCas9 | negative selection | 11758050 | 70486712 | 70486735 | 11 | - | 28162770 | HEL | viability | GCAGTGCCCTCCGCGAGCAGCGG | SHANK2 | ENSG00000162105 | 0.356117605848947 | [443] | [363] | 3 | hSpCas9 | negative selection | 11758051 | 70486581 | 70486604 | 11 | - | 28162770 | HEL | viability | TCAACAGGGACCCAAAGGGGAGG | SHANK2 | ENSG00000162105 | -0.942223668720799 | [11] | [3] | -5 | hSpCas9 | negative selection | 11758052 | 70486223 | 70486246 | 11 | - | 28162770 | HEL | viability | GAAGGTGTTTCCGAAACCGAAGG | SHANK2 | ENSG00000162105 | 1.3916770678326391 | [215] | [362] | 9 | hSpCas9 | negative selection | 11758053 | 70659872 | 70659895 | 11 | - | 28162770 | HEL | viability | GGAGTCCGTGGATGAAGGTGGGG | SHANK2 | ENSG00000162105 | 0.08381419218072395 | [301] | [204] | 0 | hSpCas9 | negative selection | 11758054 | 70502844 | 70502867 | 11 | - | 28162770 | HEL | viability | GAATCACCTGGTCCTTAAGGTGG | SHANK2 | ENSG00000162105 | 0.07190666011408893 | [253] | [170] | 0 | hSpCas9 | negative selection | 11758055 | 70492374 | 70492397 | 11 | - | 28162770 | HEL | viability | GGGTGGCGACCATCAAGCAGCGG | SHANK2 | ENSG00000162105 | 0.16052334737118357 | [358] | [256] | 1 | hSpCas9 | negative selection | 11758056 | 70487576 | 70487599 | 11 | + | 28162770 | HEL | viability | TAAGTGGTTGGGGAAGGTGGTGG | SHANK2 | ENSG00000162105 | -0.9225948619718667 | [218] | [73] | -5 | hSpCas9 | negative selection | 11758057 | 70492349 | 70492372 | 11 | - | 28162770 | MV411 | viability | CAGCAGCCGGTGCTTCCCGGCGG | SHANK2 | ENSG00000162105 | 0.26270430743608575 | [281] | [284] | 2 | hSpCas9 | negative selection | 11927414 | 70487316 | 70487339 | 11 | - | 28162770 | MV411 | viability | AGAAAACCCATACTCAGAGGTGG | SHANK2 | ENSG00000162105 | -0.2463119245101093 | [451] | [320] | -2 | hSpCas9 | negative selection | 11927415 | 70487159 | 70487182 | 11 | - | 28162770 | MV411 | viability | GAGCCGTCCACCAGCAGCAGCGG | SHANK2 | ENSG00000162105 | -0.18042398885365185 | [112] | [83] | -1 | hSpCas9 | negative selection | 11927416 | 70486712 | 70486735 | 11 | - | 28162770 | MV411 | viability | GCAGTGCCCTCCGCGAGCAGCGG | SHANK2 | ENSG00000162105 | -0.2946391370852044 | [347] | [238] | -2 | hSpCas9 | negative selection | 11927417 | 70486581 | 70486604 | 11 | - | 28162770 | MV411 | viability | TCAACAGGGACCCAAAGGGGAGG | SHANK2 | ENSG00000162105 | -0.3899923698325165 | [13] | [8] | -3 | hSpCas9 | negative selection | 11927418 | 70486223 | 70486246 | 11 | - | 28162770 | MV411 | viability | GAAGGTGTTTCCGAAACCGAAGG | SHANK2 | ENSG00000162105 | 0.2144224935548124 | [220] | [215] | 1 | hSpCas9 | negative selection | 11927419 | 70659872 | 70659895 | 11 | - | 28162770 | MV411 | viability | GGAGTCCGTGGATGAAGGTGGGG | SHANK2 | ENSG00000162105 | -1.4335716374094156 | [294] | [91] | -7 | hSpCas9 | negative selection | 11927420 | 70502844 | 70502867 | 11 | - | 28162770 | MV411 | viability | GAATCACCTGGTCCTTAAGGTGG | SHANK2 | ENSG00000162105 | -0.21711390353764604 | [246] | [178] | -2 | hSpCas9 | negative selection | 11927421 | 70492374 | 70492397 | 11 | - | 28162770 | MV411 | viability | GGGTGGCGACCATCAAGCAGCGG | SHANK2 | ENSG00000162105 | 0.12764303824806084 | [250] | [230] | 1 | hSpCas9 | negative selection | 11927422 | 70487576 | 70487599 | 11 | + | 28162770 | MV411 | viability | TAAGTGGTTGGGGAAGGTGGTGG | SHANK2 | ENSG00000162105 | -0.9749548705536726 | [188] | [80] | -6 | hSpCas9 | negative selection | 11927423 | 70492349 | 70492372 | 11 | - | 28162770 | MONOMAC1 | viability | CAGCAGCCGGTGCTTCCCGGCGG | SHANK2 | ENSG00000162105 | -0.05423624666052951 | [172] | [190] | 0 | hSpCas9 | negative selection | 12096780 | 70487316 | 70487339 | 11 | - | 28162770 | MONOMAC1 | viability | AGAAAACCCATACTCAGAGGTGG | SHANK2 | ENSG00000162105 | 1.141352494526978 | [243] | [616] | 8 | hSpCas9 | negative selection | 12096781 | 70487159 | 70487182 | 11 | - | 28162770 | MONOMAC1 | viability | GAGCCGTCCACCAGCAGCAGCGG | SHANK2 | ENSG00000162105 | 0.4948408575781144 | [64] | [104] | 5 | hSpCas9 | negative selection | 12096782 | 70486712 | 70486735 | 11 | - | 28162770 | MONOMAC1 | viability | GCAGTGCCCTCCGCGAGCAGCGG | SHANK2 | ENSG00000162105 | 0.040826983039334075 | [211] | [249] | 0 | hSpCas9 | negative selection | 12096783 | 70486581 | 70486604 | 11 | - | 28162770 | MONOMAC1 | viability | TCAACAGGGACCCAAAGGGGAGG | SHANK2 | ENSG00000162105 | 0.8029631529404462 | [7] | [15] | 7 | hSpCas9 | negative selection | 12096784 | 70486223 | 70486246 | 11 | - | 28162770 | MONOMAC1 | viability | GAAGGTGTTTCCGAAACCGAAGG | SHANK2 | ENSG00000162105 | 0.6631054893574857 | [183] | [333] | 6 | hSpCas9 | negative selection | 12096785 | 70659872 | 70659895 | 11 | - | 28162770 | MONOMAC1 | viability | GGAGTCCGTGGATGAAGGTGGGG | SHANK2 | ENSG00000162105 | -0.33317353504558256 | [210] | [191] | -3 | hSpCas9 | negative selection | 12096786 | 70502844 | 70502867 | 11 | - | 28162770 | MONOMAC1 | viability | GAATCACCTGGTCCTTAAGGTGG | SHANK2 | ENSG00000162105 | 0.5958052452991587 | [156] | [271] | 6 | hSpCas9 | negative selection | 12096787 | 70492374 | 70492397 | 11 | - | 28162770 | MONOMAC1 | viability | GGGTGGCGACCATCAAGCAGCGG | SHANK2 | ENSG00000162105 | 0.2796727630095791 | [165] | [230] | 3 | hSpCas9 | negative selection | 12096788 | 70487576 | 70487599 | 11 | + | 28162770 | MONOMAC1 | viability | TAAGTGGTTGGGGAAGGTGGTGG | SHANK2 | ENSG00000162105 | -0.8554204172500792 | [130] | [82] | -6 | hSpCas9 | negative selection | 12096789 | 70492349 | 70492372 | 11 | - | 28162770 | OCIAML2 | viability | CAGCAGCCGGTGCTTCCCGGCGG | SHANK2 | ENSG00000162105 | -0.09125145817089919 | [63] | [332] | 0 | hSpCas9 | negative selection | 12266146 | 70487316 | 70487339 | 11 | - | 28162770 | OCIAML2 | viability | AGAAAACCCATACTCAGAGGTGG | SHANK2 | ENSG00000162105 | 0.03616106132188279 | [78] | [448] | 0 | hSpCas9 | negative selection | 12266147 | 70487159 | 70487182 | 11 | - | 28162770 | OCIAML2 | viability | GAGCCGTCCACCAGCAGCAGCGG | SHANK2 | ENSG00000162105 | 1.0912490623659536 | [20] | [247] | 9 | hSpCas9 | negative selection | 12266148 | 70486712 | 70486735 | 11 | - | 28162770 | OCIAML2 | viability | GCAGTGCCCTCCGCGAGCAGCGG | SHANK2 | ENSG00000162105 | -0.08865434668485994 | [79] | [416] | 0 | hSpCas9 | negative selection | 12266149 | 70486581 | 70486604 | 11 | - | 28162770 | OCIAML2 | viability | TCAACAGGGACCCAAAGGGGAGG | SHANK2 | ENSG00000162105 | 0.22980989289893072 | [3] | [25] | 2 | hSpCas9 | negative selection | 12266150 | 70486223 | 70486246 | 11 | - | 28162770 | OCIAML2 | viability | GAAGGTGTTTCCGAAACCGAAGG | SHANK2 | ENSG00000162105 | 0.7528584526155597 | [46] | [438] | 7 | hSpCas9 | negative selection | 12266151 | 70659872 | 70659895 | 11 | - | 28162770 | OCIAML2 | viability | GGAGTCCGTGGATGAAGGTGGGG | SHANK2 | ENSG00000162105 | 0.28301451007067524 | [42] | [289] | 2 | hSpCas9 | negative selection | 12266152 | 70502844 | 70502867 | 11 | - | 28162770 | OCIAML2 | viability | GAATCACCTGGTCCTTAAGGTGG | SHANK2 | ENSG00000162105 | -0.6718880334892651 | [47] | [166] | -5 | hSpCas9 | negative selection | 12266153 | 70492374 | 70492397 | 11 | - | 28162770 | OCIAML2 | viability | GGGTGGCGACCATCAAGCAGCGG | SHANK2 | ENSG00000162105 | 0.3136414837024015 | [53] | [371] | 3 | hSpCas9 | negative selection | 12266154 | 70487576 | 70487599 | 11 | + | 28162770 | OCIAML2 | viability | TAAGTGGTTGGGGAAGGTGGTGG | SHANK2 | ENSG00000162105 | -0.7837877105017915 | [40] | [131] | -5 | hSpCas9 | negative selection | 12266155 | 70492349 | 70492372 | 11 | - | 28162770 | OCIAML3 | viability | CAGCAGCCGGTGCTTCCCGGCGG | SHANK2 | ENSG00000162105 | 0.465773588001254 | [64] | [270] | 4 | hSpCas9 | negative selection | 12435512 | 70487316 | 70487339 | 11 | - | 28162770 | OCIAML3 | viability | AGAAAACCCATACTCAGAGGTGG | SHANK2 | ENSG00000162105 | 1.2379672485064446 | [82] | [590] | 8 | hSpCas9 | negative selection | 12435513 | 70487159 | 70487182 | 11 | - | 28162770 | OCIAML3 | viability | GAGCCGTCCACCAGCAGCAGCGG | SHANK2 | ENSG00000162105 | -1.797541034409295 | [37] | [32] | -8 | hSpCas9 | negative selection | 12435514 | 70486712 | 70486735 | 11 | - | 28162770 | OCIAML3 | viability | GCAGTGCCCTCCGCGAGCAGCGG | SHANK2 | ENSG00000162105 | 0.11310196968278363 | [82] | [270] | 1 | hSpCas9 | negative selection | 12435515 | 70486581 | 70486604 | 11 | - | 28162770 | OCIAML3 | viability | TCAACAGGGACCCAAAGGGGAGG | SHANK2 | ENSG00000162105 | 2.7458423625604613 | [3] | [80] | 9 | hSpCas9 | negative selection | 12435516 | 70486223 | 70486246 | 11 | - | 28162770 | OCIAML3 | viability | GAAGGTGTTTCCGAAACCGAAGG | SHANK2 | ENSG00000162105 | 0.5380958956831821 | [72] | [319] | 5 | hSpCas9 | negative selection | 12435517 | 70659872 | 70659895 | 11 | - | 28162770 | OCIAML3 | viability | GGAGTCCGTGGATGAAGGTGGGG | SHANK2 | ENSG00000162105 | -0.8074112784333565 | [79] | [137] | -6 | hSpCas9 | negative selection | 12435518 | 70502844 | 70502867 | 11 | - | 28162770 | OCIAML3 | viability | GAATCACCTGGTCCTTAAGGTGG | SHANK2 | ENSG00000162105 | 0.2500420817141239 | [60] | [218] | 2 | hSpCas9 | negative selection | 12435519 | 70492374 | 70492397 | 11 | - | 28162770 | OCIAML3 | viability | GGGTGGCGACCATCAAGCAGCGG | SHANK2 | ENSG00000162105 | -0.2638590386318322 | [69] | [175] | -2 | hSpCas9 | negative selection | 12435520 | 70487576 | 70487599 | 11 | + | 28162770 | OCIAML3 | viability | TAAGTGGTTGGGGAAGGTGGTGG | SHANK2 | ENSG00000162105 | -0.8965704103445944 | [73] | [119] | -6 | hSpCas9 | negative selection | 12435521 |