Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:4086
• Symbol:SMAD1
• Description:SMAD family member 1

DataSource: http://genomecrispr.dkfz.de/#!/results/SMAD1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
145542674	145542697	4	+	26472758	Jiyoye	viability	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.27472508548222374	[113]	[103]	2	hSpCas9	negative selection	151556
145539946	145539969	4	-	26472758	Jiyoye	viability	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	-0.15917144104793596	[153]	[103]	-1	hSpCas9	negative selection	151557
145539845	145539868	4	-	26472758	Jiyoye	viability	TGAGCTAAGAGGCTGTGCTGAGG	SMAD1	ENSG00000170365	-0.7495501221815797	[135]	[60]	-5	hSpCas9	negative selection	151558
145542674	145542697	4	+	26472758	KBM7	viability	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.1442396679493585	[315,289]	[175,140]	1	hSpCas9	negative selection	342674
145539946	145539969	4	-	26472758	KBM7	viability	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	0.6619034386457913	[490,363]	[347,284]	7	hSpCas9	negative selection	342675
145539845	145539868	4	-	26472758	KBM7	viability	TGAGCTAAGAGGCTGTGCTGAGG	SMAD1	ENSG00000170365	0.9132850536038256	[473,391]	[549,230]	8	hSpCas9	negative selection	342676
145542674	145542697	4	+	26472758	Raji	viability	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.6064852994409178	[149]	[52]	6	hSpCas9	negative selection	533792
145539946	145539969	4	-	26472758	Raji	viability	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	0.7498315307555157	[163]	[63]	7	hSpCas9	negative selection	533793
145539845	145539868	4	-	26472758	Raji	viability	TGAGCTAAGAGGCTGTGCTGAGG	SMAD1	ENSG00000170365	0.37267391514776116	[212]	[63]	3	hSpCas9	negative selection	533794
145542674	145542697	4	+	26472758	K562	viability	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.7262877354234993	[289]	[404]	6	hSpCas9	negative selection	724910
145539946	145539969	4	-	26472758	K562	viability	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	0.6732620264703211	[285]	[384]	5	hSpCas9	negative selection	724911
145539845	145539868	4	-	26472758	K562	viability	TGAGCTAAGAGGCTGTGCTGAGG	SMAD1	ENSG00000170365	1.0310150895572536	[399]	[689]	8	hSpCas9	negative selection	724912
145542628	145542651	4	+	26627737	DLD1	viability	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	0.5769423754501123	[449]	[214,202,210]	6	hSpCas9	negative selection	824003
145542674	145542697	4	+	26627737	DLD1	viability	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.10411370627835526	[823]	[308,271,252]	1	hSpCas9	negative selection	824004
145546793	145546816	4	-	26627737	DLD1	viability	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	0.3487654224996889	[829]	[354,408,243]	3	hSpCas9	negative selection	824005
145557808	145557831	4	-	26627737	DLD1	viability	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	-0.14827375639373974	[1162]	[425,297,267]	-1	hSpCas9	negative selection	824006
145542628	145542651	4	+	26627737	GBM cells	viability after 5 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	-0.2888709119661754	[253]	[96,125]	-4	hSpCas9	negative selection	906318
145542674	145542697	4	+	26627737	GBM cells	viability after 5 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.09056043274607872	[541]	[303,314]	1	hSpCas9	negative selection	906319
145546793	145546816	4	-	26627737	GBM cells	viability after 5 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	0.10107181248207964	[358]	[176,235]	1	hSpCas9	negative selection	906320
145557808	145557831	4	-	26627737	GBM cells	viability after 5 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	-0.4381211123918852	[431]	[151,189]	-6	hSpCas9	negative selection	906321
145542628	145542651	4	+	26627737	GBM cells	viability after 13 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	0.14782184686809963	[253]	[139,162]	2	hSpCas9	negative selection	988633
145542674	145542697	4	+	26627737	GBM cells	viability after 13 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.14949550808777934	[541]	[350,305]	2	hSpCas9	negative selection	988634
145546793	145546816	4	-	26627737	GBM cells	viability after 13 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	0.31715351405431136	[358]	[288,204]	4	hSpCas9	negative selection	988635
145557808	145557831	4	-	26627737	GBM cells	viability after 13 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	-0.288098155664148	[431]	[261,134]	-3	hSpCas9	negative selection	988636
145542628	145542651	4	+	26627737	GBM cells	viability after 21 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	-0.013230206285174066	[253]	[142,130]	0	hSpCas9	negative selection	1070948
145542674	145542697	4	+	26627737	GBM cells	viability after 21 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.11825801170371308	[541]	[316,321]	1	hSpCas9	negative selection	1070949
145546793	145546816	4	-	26627737	GBM cells	viability after 21 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	0.5013822838502334	[358]	[273,277]	5	hSpCas9	negative selection	1070950
145557808	145557831	4	-	26627737	GBM cells	viability after 21 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	-0.1666816145032295	[431]	[206,210]	-1	hSpCas9	negative selection	1070951
145542628	145542651	4	+	26627737	RPE1	viability after 9 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	-0.6616381229189809	[968]	[141,255]	-5	hSpCas9	negative selection	1153263
145542674	145542697	4	+	26627737	RPE1	viability after 9 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	-0.11667713926691126	[1969]	[515,636]	-1	hSpCas9	negative selection	1153264
145546793	145546816	4	-	26627737	RPE1	viability after 9 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	-0.8056342668647045	[1069]	[140,256]	-5	hSpCas9	negative selection	1153265
145557808	145557831	4	-	26627737	RPE1	viability after 9 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	0.6284359605228971	[1027]	[538,443]	4	hSpCas9	negative selection	1153266
145542628	145542651	4	+	26627737	RPE1	viability after 12 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	-0.662924247667317	[968]	[195,130]	-4	hSpCas9	negative selection	1235578
145542674	145542697	4	+	26627737	RPE1	viability after 12 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.17599530588251522	[1969]	[731,455]	1	hSpCas9	negative selection	1235579
145546793	145546816	4	-	26627737	RPE1	viability after 12 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	-1.3185713179473764	[1069]	[140,87]	-7	hSpCas9	negative selection	1235580
145557808	145557831	4	-	26627737	RPE1	viability after 12 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	0.8760848743757734	[1027]	[418,599]	5	hSpCas9	negative selection	1235581
145542628	145542651	4	+	26627737	RPE1	viability after 15 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	-0.3820754600579923	[968]	[275,146]	-2	hSpCas9	negative selection	1317893
145542674	145542697	4	+	26627737	RPE1	viability after 15 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	-0.20402210349889072	[1969]	[467,498]	-1	hSpCas9	negative selection	1317894
145546793	145546816	4	-	26627737	RPE1	viability after 15 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	-0.4518839150432003	[1069]	[373,73]	-3	hSpCas9	negative selection	1317895
145557808	145557831	4	-	26627737	RPE1	viability after 15 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	0.6257433374338397	[1027]	[380,513]	4	hSpCas9	negative selection	1317896
145542628	145542651	4	+	26627737	RPE1	viability after 18 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	-0.9127276592236175	[968]	[208,63]	-5	hSpCas9	negative selection	1400208
145542674	145542697	4	+	26627737	RPE1	viability after 18 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.12598640879516787	[1969]	[540,621]	0	hSpCas9	negative selection	1400209
145546793	145546816	4	-	26627737	RPE1	viability after 18 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	0.10965782607272068	[1069]	[429,184]	0	hSpCas9	negative selection	1400210
145557808	145557831	4	-	26627737	RPE1	viability after 18 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	0.7631768692240739	[1027]	[451,490]	5	hSpCas9	negative selection	1400211
145542628	145542651	4	+	26627737	HeLa	viability after 8 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	-0.17932175846125764	[364]	[131,87,194]	-2	hSpCas9	negative selection	1482523
145542674	145542697	4	+	26627737	HeLa	viability after 8 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.38755132843788	[757]	[415,546,334]	3	hSpCas9	negative selection	1482524
145546793	145546816	4	-	26627737	HeLa	viability after 8 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	-0.6950574805729292	[871]	[422,151,173]	-6	hSpCas9	negative selection	1482525
145557808	145557831	4	-	26627737	HeLa	viability after 8 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	0.02691924245566557	[757]	[565,367,138]	0	hSpCas9	negative selection	1482526
145542628	145542651	4	+	26627737	HeLa	viability after 12 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	0.4027639421326014	[364]	[163,210,220]	3	hSpCas9	negative selection	1564838
145542674	145542697	4	+	26627737	HeLa	viability after 12 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	-0.8683197104580566	[757]	[221,173,119]	-7	hSpCas9	negative selection	1564839
145546793	145546816	4	-	26627737	HeLa	viability after 12 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	-0.8362476032271435	[871]	[118,268,207]	-6	hSpCas9	negative selection	1564840
145557808	145557831	4	-	26627737	HeLa	viability after 12 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	0.016092226865231596	[757]	[350,262,342]	0	hSpCas9	negative selection	1564841
145542628	145542651	4	+	26627737	HeLa	viability after 15 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	0.794706278770144	[364]	[308,116,353]	6	hSpCas9	negative selection	1647153
145542674	145542697	4	+	26627737	HeLa	viability after 15 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	-0.070207265966439	[757]	[337,275,264]	0	hSpCas9	negative selection	1647154
145546793	145546816	4	-	26627737	HeLa	viability after 15 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	-1.1437543570584943	[871]	[263,75,138]	-7	hSpCas9	negative selection	1647155
145557808	145557831	4	-	26627737	HeLa	viability after 15 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	0.47515643747350644	[757]	[494,494,284]	4	hSpCas9	negative selection	1647156
145542628	145542651	4	+	26627737	HeLa	viability after 18 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	0.8219767792183307	[364]	[211,102,353]	6	hSpCas9	negative selection	1729468
145542674	145542697	4	+	26627737	HeLa	viability after 18 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	-0.09364989116163569	[757]	[221,222,264]	-1	hSpCas9	negative selection	1729469
145546793	145546816	4	-	26627737	HeLa	viability after 18 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	-1.1967877216842435	[871]	[164,63,138]	-8	hSpCas9	negative selection	1729470
145557808	145557831	4	-	26627737	HeLa	viability after 18 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	0.4892190919915169	[757]	[336,413,284]	4	hSpCas9	negative selection	1729471
145542628	145542651	4	+	26627737	HCT116	viability after 6 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	0.6064017617939546	[488]	[156,94]	3	hSpCas9	negative selection	1811783
145542674	145542697	4	+	26627737	HCT116	viability after 6 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	-0.15486456414451588	[1746]	[256,240]	-1	hSpCas9	negative selection	1811784
145546793	145546816	4	-	26627737	HCT116	viability after 6 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	-0.24176293915860136	[1607]	[430,93]	-1	hSpCas9	negative selection	1811785
145557808	145557831	4	-	26627737	HCT116	viability after 6 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	0.278050950393808	[1413]	[90,367]	1	hSpCas9	negative selection	1811786
145542628	145542651	4	+	26627737	HCT116	viability after 8 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	-0.5562926071327098	[464]	[155,157,207]	-6	hSpCas9	negative selection	1894098
145542674	145542697	4	+	26627737	HCT116	viability after 8 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	-0.15259794958117823	[820]	[416,385,417]	-2	hSpCas9	negative selection	1894099
145546793	145546816	4	-	26627737	HCT116	viability after 8 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	0.5419984459922966	[297]	[315,194,207]	5	hSpCas9	negative selection	1894100
145557808	145557831	4	-	26627737	HCT116	viability after 8 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	-0.09664064349197066	[546]	[321,294,229]	-1	hSpCas9	negative selection	1894101
145542628	145542651	4	+	26627737	HCT116	viability after 9 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	0.36917610452189564	[488]	[233,116]	2	hSpCas9	negative selection	1976413
145542674	145542697	4	+	26627737	HCT116	viability after 9 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.49443152393381906	[1746]	[936,435]	3	hSpCas9	negative selection	1976414
145546793	145546816	4	-	26627737	HCT116	viability after 9 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	-0.3101194999141499	[1607]	[514,212]	-2	hSpCas9	negative selection	1976415
145557808	145557831	4	-	26627737	HCT116	viability after 9 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	-0.955781303550738	[1413]	[278,127]	-6	hSpCas9	negative selection	1976416
145542628	145542651	4	+	26627737	HCT116	viability after 12 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	-0.1819643105808244	[464]	[219,180,243]	-2	hSpCas9	negative selection	2058728
145542674	145542697	4	+	26627737	HCT116	viability after 12 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	-0.36494401536884125	[820]	[460,251,278]	-4	hSpCas9	negative selection	2058729
145546793	145546816	4	-	26627737	HCT116	viability after 12 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	1.2405280260558846	[297]	[451,290,357]	8	hSpCas9	negative selection	2058730
145557808	145557831	4	-	26627737	HCT116	viability after 12 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	-0.032446255498728704	[546]	[445,209,170]	0	hSpCas9	negative selection	2058731
145542628	145542651	4	+	26627737	HCT116	viability after 15 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	-0.2207544573631699	[464]	[149,145,379]	-2	hSpCas9	negative selection	2141043
145542674	145542697	4	+	26627737	HCT116	viability after 15 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	-0.3996308613254118	[820]	[413,295,368]	-4	hSpCas9	negative selection	2141044
145546793	145546816	4	-	26627737	HCT116	viability after 15 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	0.8092011755445583	[297]	[258,363,271]	7	hSpCas9	negative selection	2141045
145557808	145557831	4	-	26627737	HCT116	viability after 15 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	0.3747924873118107	[546]	[364,374,475]	3	hSpCas9	negative selection	2141046
145542628	145542651	4	+	26627737	HCT116	viability after 18 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	-0.22957214134772957	[464]	[157,95,333]	-2	hSpCas9	negative selection	2223358
145542674	145542697	4	+	26627737	HCT116	viability after 18 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	-0.249873872039579	[820]	[413,286,301]	-2	hSpCas9	negative selection	2223359
145546793	145546816	4	-	26627737	HCT116	viability after 18 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	1.4198121277249132	[297]	[397,314,450]	8	hSpCas9	negative selection	2223360
145557808	145557831	4	-	26627737	HCT116	viability after 18 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	0.3008714681385354	[546]	[462,254,260]	2	hSpCas9	negative selection	2223361
145482648	145482671	4	-	25494202	A375	resistance to PLX-4720 (puromycin)	CCTTGACCTCGACCCCAAAGAGG	SMAD1	ENSG00000170365	-1.6235309449031743	[351,60]	[22,4]	-8	dCas9-VP64	positive selection	2385913
145482617	145482640	4	-	25494202	A375	resistance to PLX-4720 (puromycin)	GGCCGAGAAGAAAACCCGTGCGG	SMAD1	ENSG00000170365	0.6803500749542497	[34,76]	[4,34]	3	dCas9-VP64	positive selection	2385914
145482697	145482720	4	+	25494202	A375	resistance to PLX-4720 (puromycin)	TTTATTCAAAGGTTTGGCGGCGG	SMAD1	ENSG00000170365	-2.2008081483170114	[155,17]	[5,0]	-9	dCas9-VP64	positive selection	2385915
145527364	145527387	4	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGCGCCCGCCACTACGCCCAG	SMAD1	ENSG00000170365	0.2542442645597387	[125,35]	[32,6]	1	dCas9-VP64	positive selection	2390343
145522271	145522294	4	-	25494202	A375	resistance to PLX-4720 (puromycin)	AGAGTCTTGCTCTGTCGCCCTGG	SMAD1	ENSG00000170365	1.2077108984929388	[2,0]	[0,0]	5	dCas9-VP64	positive selection	2399354
145481615	145481638	4	-	25494202	A375	resistance to PLX-4720 (puromycin)	CCGGAGCCACCCCCTTCTACCGG	SMAD1	ENSG00000170365	-0.582991725593166	[135,532]	[38,60]	-3	dCas9-VP64	positive selection	2438832
145481684	145481707	4	-	25494202	A375	resistance to PLX-4720 (puromycin)	CTCCAAATTCCCGGCCCGGCCGG	SMAD1	ENSG00000170365	-1.538828117493925	[413,443]	[28,35]	-8	dCas9-VP64	positive selection	2438833
145481709	145481732	4	+	25494202	A375	resistance to PLX-4720 (puromycin)	GATCCCTGGTCGCGCGGCAGCGG	SMAD1	ENSG00000170365	0.25202480618294065	[27,14]	[7,2]	1	dCas9-VP64	positive selection	2438834
145482648	145482671	4	-	25494202	A375	resistance to PLX-4720 (zeocin)	CCTTGACCTCGACCCCAAAGAGG	SMAD1	ENSG00000170365	0.0792011789117476	[51,170]	[21,51]	0	dCas9-VP64	positive selection	2481168
145482617	145482640	4	-	25494202	A375	resistance to PLX-4720 (zeocin)	GGCCGAGAAGAAAACCCGTGCGG	SMAD1	ENSG00000170365	-1.4984911261689708	[88,177]	[19,9]	-9	dCas9-VP64	positive selection	2481169
145482697	145482720	4	+	25494202	A375	resistance to PLX-4720 (zeocin)	TTTATTCAAAGGTTTGGCGGCGG	SMAD1	ENSG00000170365	0.7187286846985014	[41,80]	[16,46]	5	dCas9-VP64	positive selection	2481170
145527364	145527387	4	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGCGCCCGCCACTACGCCCAG	SMAD1	ENSG00000170365	-0.461140309760111	[122,83]	[30,17]	-5	dCas9-VP64	positive selection	2485598
145522271	145522294	4	-	25494202	A375	resistance to PLX-4720 (zeocin)	AGAGTCTTGCTCTGTCGCCCTGG	SMAD1	ENSG00000170365	-0.1122041493399547	[42,120]	[2,43]	-1	dCas9-VP64	positive selection	2494609
145481615	145481638	4	-	25494202	A375	resistance to PLX-4720 (zeocin)	CCGGAGCCACCCCCTTCTACCGG	SMAD1	ENSG00000170365	1.0347627048807087	[178,72]	[35,129]	6	dCas9-VP64	positive selection	2534087
145481684	145481707	4	-	25494202	A375	resistance to PLX-4720 (zeocin)	CTCCAAATTCCCGGCCCGGCCGG	SMAD1	ENSG00000170365	-0.618346627565903	[32,144]	[13,22]	-6	dCas9-VP64	positive selection	2534088
145481709	145481732	4	+	25494202	A375	resistance to PLX-4720 (zeocin)	GATCCCTGGTCGCGCGGCAGCGG	SMAD1	ENSG00000170365	0.0881022829785637	[92,65]	[19,33]	0	dCas9-VP64	positive selection	2534089
145539799	145539822	4	+	27260157	DLD1	viability	TCTAGTACTTCCTCCTGTGCTGG	SMAD1	ENSG00000170365	-1.39916492630276	[]	[]	-8	hSpCas9	negative selection	2608553
145539799	145539822	4	+	27260157	HT1080	viability	TCTAGTACTTCCTCCTGTGCTGG	SMAD1	ENSG00000170365	-0.708581135616497	[]	[]	-8	hSpCas9	negative selection	2684683
145539799	145539822	4	+	27260157	MKN45	viability	TCTAGTACTTCCTCCTGTGCTGG	SMAD1	ENSG00000170365	-0.718784600560165	[]	[]	-7	hSpCas9	negative selection	2760813
145539799	145539822	4	+	27260157	RKO	viability	TCTAGTACTTCCTCCTGTGCTGG	SMAD1	ENSG00000170365	-0.909486969157673	[]	[]	-8	hSpCas9	negative selection	2836943
145539799	145539822	4	+	27260157	SF268	viability	TCTAGTACTTCCTCCTGTGCTGG	SMAD1	ENSG00000170365	-0.812223144191922	[]	[]	-6	hSpCas9	negative selection	2913073
145539946	145539969	4	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	0.3564512630800715	[2,2]	[1,4]	7	hSpCas9	positive selection	3021994
145539946	145539969	4	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	0.5010140154239637	[2,2]	[1,3]	8	hSpCas9	positive selection	3089852
145546831	145546854		-	24336571	A375	resistance to PLX after 7 days	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.12611510438495432	[9,9]	[9,7]	-4	hSpCas9	positive selection	3146045
145546886	145546909		+	24336571	A375	resistance to PLX after 7 days	ATTCCACTATTGAAAACACCAGG	SMAD1	ENSG00000170365	0.14258585164747045	[5,9]	[8,9]	4	hSpCas9	positive selection	3146046
145546755	145546778		+	24336571	A375	resistance to PLX after 7 days	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.031105719774107254	[20,16]	[18,18]	1	hSpCas9	positive selection	3146047
145539860	145539883		+	24336571	A375	resistance to PLX after 7 days	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.007124499919658911	[33,31]	[32,31]	0	hSpCas9	positive selection	3146048
145546831	145546854		-	24336571	A375	resistance to PLX after 14 days	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	0.8918348237252706	[6,8]	[6,6]	7	hSpCas9	positive selection	3203838
145546886	145546909		+	24336571	A375	resistance to PLX after 14 days	ATTCCACTATTGAAAACACCAGG	SMAD1	ENSG00000170365	0.6606474182695674	[7,4]	[6,2]	6	hSpCas9	positive selection	3203839
145546755	145546778		+	24336571	A375	resistance to PLX after 14 days	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	-0.2695535970077235	[16,21]	[6,6]	-3	hSpCas9	positive selection	3203840
145539860	145539883		+	24336571	A375	resistance to PLX after 14 days	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.45500642472230135	[28,24]	[16,15]	4	hSpCas9	positive selection	3203841
145546831	145546854		-	24336571	A375	viability after 7 days	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	0.2240155636015344	[8]	[9,9]	3	hSpCas9	negative selection	3261631
145546886	145546909		+	24336571	A375	viability after 7 days	ATTCCACTATTGAAAACACCAGG	SMAD1	ENSG00000170365	-1.070069361924925	[18]	[5,9]	-9	hSpCas9	negative selection	3261632
145546755	145546778		+	24336571	A375	viability after 7 days	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.45793374681219123	[13]	[20,16]	7	hSpCas9	negative selection	3261633
145539860	145539883		+	24336571	A375	viability after 7 days	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.25426519788503943	[28]	[33,31]	4	hSpCas9	negative selection	3261634
145546831	145546854		-	24336571	A375	viability after 14 days	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.10505075239631212	[8]	[6,8]	-1	hSpCas9	negative selection	3319424
145546886	145546909		+	24336571	A375	viability after 14 days	ATTCCACTATTGAAAACACCAGG	SMAD1	ENSG00000170365	-1.335881011145239	[18]	[7,4]	-9	hSpCas9	negative selection	3319425
145546755	145546778		+	24336571	A375	viability after 14 days	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.5429957236932714	[13]	[16,21]	7	hSpCas9	negative selection	3319426
145539860	145539883		+	24336571	A375	viability after 14 days	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	-0.008091205207075847	[28]	[28,24]	0	hSpCas9	negative selection	3319427
145546831	145546854	4	-	27383988	293T	resistance to West Nile virus (flavivirus)	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	1.7027373597681978	[46,46]	[0,0]	7	hSpCas9	positive selection	3393735
145539812	145539835	4	-	27383988	293T	resistance to West Nile virus (flavivirus)	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	-0.3937254797330937	[200,200]	[0,0]	-2	hSpCas9	positive selection	3393736
145542644	145542667	4	-	27383988	293T	resistance to West Nile virus (flavivirus)	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	-1.7788474011076498	[524,524]	[0,0]	-9	hSpCas9	positive selection	3393737
145539946	145539969	4	-	26780180	HT29	viability (Avana library 4 designs)	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	1.39553353844758	[]	[]	5	hSpCas9	negative selection	3460568
145539946	145539969	4	-	26780180	A375	viability (Avana lentiCRISPRv2)	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	2.17754736112525	[]	[]	3	hSpCas9	negative selection	3561007
145539972	145539995	4	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCAGTTACCCAAACTCTCCTGGG	SMAD1	ENSG00000170365	-1.81890901200743	[]	[]	-2	hSpCas9	negative selection	3561008
145539946	145539969	4	-	26780180	A375	viability (Avana lentiGuide)	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	28.2428567568114	[]	[]	9	hSpCas9	negative selection	3669666
145539972	145539995	4	+	26780180	A375	viability (Avana lentiGuide)	GCAGTTACCCAAACTCTCCTGGG	SMAD1	ENSG00000170365	-3.09430218608102	[]	[]	-5	hSpCas9	negative selection	3669667
145539946	145539969	4	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	0.16824486765689228	[4]	[5,4]	4	hSpCas9	positive selection	3778273
145539972	145539995	4	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCAGTTACCCAAACTCTCCTGGG	SMAD1	ENSG00000170365	-0.0690832559848598	[4]	[5,3]	-1	hSpCas9	positive selection	3778274
145539946	145539969	4	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	-1.2944936431343237	[4]	[0,1]	-9	hSpCas9	positive selection	3886880
145539972	145539995	4	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCAGTTACCCAAACTCTCCTGGG	SMAD1	ENSG00000170365	0.2346769909069783	[5]	[5,6]	6	hSpCas9	positive selection	3886881
145546831	145546854	4	-	26780180	A375	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	0.605143187586846	[]	[]	2	hSpCas9	negative selection	3996988
145546755	145546778	4	+	26780180	A375	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.748599444668617	[]	[]	2	hSpCas9	negative selection	3996989
145539812	145539835	4	-	26780180	A375	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	1.21701382524749	[]	[]	6	hSpCas9	negative selection	3996990
145542644	145542667	4	-	26780180	A375	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.942043141405752	[]	[]	4	hSpCas9	negative selection	3996991
145554019	145554042	4	+	26780180	A375	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	0.961114453279094	[]	[]	4	hSpCas9	negative selection	3996992
145539860	145539883	4	+	26780180	A375	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	1.34057731744635	[]	[]	7	hSpCas9	negative selection	3996993
145546831	145546854	4	-	26780180	HT29	viability (GeCKOv2 library)	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	0.930941133138097	[]	[]	4	hSpCas9	negative selection	4104954
145546755	145546778	4	+	26780180	HT29	viability (GeCKOv2 library)	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.972368716123471	[]	[]	4	hSpCas9	negative selection	4104955
145539812	145539835	4	-	26780180	HT29	viability (GeCKOv2 library)	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	1.16663995683382	[]	[]	5	hSpCas9	negative selection	4104956
145542644	145542667	4	-	26780180	HT29	viability (GeCKOv2 library)	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.512010419661109	[]	[]	1	hSpCas9	negative selection	4104957
145554019	145554042	4	+	26780180	HT29	viability (GeCKOv2 library)	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	0.71694595567244	[]	[]	2	hSpCas9	negative selection	4104958
145539860	145539883	4	+	26780180	HT29	viability (GeCKOv2 library)	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	1.07928091784989	[]	[]	5	hSpCas9	negative selection	4104959
145546831	145546854	4	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	0.05454432033448511	[3]	[2,2]	1	hSpCas9	positive selection	4172119
145546886	145546909	4	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	ATTCCACTATTGAAAACACCAGG	SMAD1	ENSG00000170365	-0.22887221214347211	[3]	[1,1]	-5	hSpCas9	positive selection	4172120
145546755	145546778	4	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.02149074149215044	[4]	[2,2]	0	hSpCas9	positive selection	4172121
145539860	145539883	4	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.6529850243449977	[4]	[6,4]	9	hSpCas9	positive selection	4172122
145546831	145546854	4	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.3666042544613091	[3]	[0,0,1,0]	-5	hSpCas9	positive selection	4236141
145546886	145546909	4	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	ATTCCACTATTGAAAACACCAGG	SMAD1	ENSG00000170365	0.9039711863809039	[4]	[3,0,5,3]	6	hSpCas9	positive selection	4236142
145546755	145546778	4	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.8821122745477455	[3]	[1,2,0,3]	6	hSpCas9	positive selection	4236143
145539860	145539883	4	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.975329273579707	[4]	[4,4,2,3]	6	hSpCas9	positive selection	4236144
145539860	145539883	4	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.08061806665883964	[3]	[3,1]	1	hSpCas9	positive selection	4299198
145546755	145546778	4	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.05220409828796177	[3]	[3,2]	1	hSpCas9	positive selection	4299199
145554019	145554042	4	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	0.01840246882117688	[3]	[3,1]	0	hSpCas9	positive selection	4299200
145546831	145546854	4	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.1675972044917835	[1]	[0,0]	-3	hSpCas9	positive selection	4363451
145539812	145539835	4	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	-0.17427447219489445	[3]	[3,1]	-4	hSpCas9	positive selection	4363452
145542644	145542667	4	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	-0.030038869460188855	[3]	[3,2]	0	hSpCas9	positive selection	4363453
145539856	145539878	4	-	27760321	OCIAML3	viability	GTTACGGAACTGAGCTAAGAGG	SMAD1	ENSG00000170365	0.546894525561489	[239,206]	[202,321]	6	hSpCas9	negative selection	4441201
145540051	145540073	4	-	27760321	OCIAML3	viability	TTCCAACCTACCTGGCATCTGG	SMAD1	ENSG00000170365	0.06252709846944338	[893,800]	[653,739]	0	hSpCas9	negative selection	4441202
145539856	145539878	4	-	27760321	OCIAML2	viability	GTTACGGAACTGAGCTAAGAGG	SMAD1	ENSG00000170365	0.7092700913691348	[239,206]	[283,308]	8	hSpCas9	negative selection	4524664
145540051	145540073	4	-	27760321	OCIAML2	viability	TTCCAACCTACCTGGCATCTGG	SMAD1	ENSG00000170365	0.584918058180493	[893,800]	[948,1129]	7	hSpCas9	negative selection	4524665
145539856	145539878	4	-	27760321	MV411	viability	GTTACGGAACTGAGCTAAGAGG	SMAD1	ENSG00000170365	0.7771798428887384	[239,206]	[82,505]	6	hSpCas9	negative selection	4608127
145540051	145540073	4	-	27760321	MV411	viability	TTCCAACCTACCTGGCATCTGG	SMAD1	ENSG00000170365	1.1587941536434991	[893,800]	[1432,967]	8	hSpCas9	negative selection	4608128
145539856	145539878	4	-	27760321	HL60	viability	GTTACGGAACTGAGCTAAGAGG	SMAD1	ENSG00000170365	0.2347619204352921	[239,206]	[188,240]	3	hSpCas9	negative selection	4691590
145540051	145540073	4	-	27760321	HL60	viability	TTCCAACCTACCTGGCATCTGG	SMAD1	ENSG00000170365	0.6444440029568118	[893,800]	[909,1261]	7	hSpCas9	negative selection	4691591
145539856	145539878	4	-	27760321	HT1080	viability	GTTACGGAACTGAGCTAAGAGG	SMAD1	ENSG00000170365	0.33503153120503504	[206,161]	[86,98]	1	hSpCas9	negative selection	4775053
145540051	145540073	4	-	27760321	HT1080	viability	TTCCAACCTACCTGGCATCTGG	SMAD1	ENSG00000170365	-0.6417935587817818	[800,624]	[203,157]	-3	hSpCas9	negative selection	4775054
145539856	145539878	4	-	27760321	HT29	viability after 7 days	GTTACGGAACTGAGCTAAGAGG	SMAD1	ENSG00000170365	-0.38599640975189287	[206,161]	[329,130,106]	-5	hSpCas9	negative selection	4858516
145540051	145540073	4	-	27760321	HT29	viability after 7 days	TTCCAACCTACCTGGCATCTGG	SMAD1	ENSG00000170365	0.15415144838306416	[800,624]	[1321,988,797]	2	hSpCas9	negative selection	4858517
145539856	145539878	4	-	27760321	HT29	viability after 25 days	GTTACGGAACTGAGCTAAGAGG	SMAD1	ENSG00000170365	0.2718206522941162	[206,161]	[312,215,227]	3	hSpCas9	negative selection	4941979
145540051	145540073	4	-	27760321	HT29	viability after 25 days	TTCCAACCTACCTGGCATCTGG	SMAD1	ENSG00000170365	0.45294648909254254	[800,624]	[843,1026,1533]	5	hSpCas9	negative selection	4941980
145539856	145539878	4	-	27760321	HT29	viability after 22 days	GTTACGGAACTGAGCTAAGAGG	SMAD1	ENSG00000170365	0.8922342845959186	[206,161]	[354,534,297]	8	hSpCas9	negative selection	5025442
145540051	145540073	4	-	27760321	HT29	viability after 22 days	TTCCAACCTACCTGGCATCTGG	SMAD1	ENSG00000170365	0.42736449397368226	[800,624]	[1287,860,1171]	4	hSpCas9	negative selection	5025443
145539856	145539878	4	-	27760321	HT29	viability after 19 days	GTTACGGAACTGAGCTAAGAGG	SMAD1	ENSG00000170365	0.3355858201900205	[206,161]	[234,173,381]	3	hSpCas9	negative selection	5108905
145540051	145540073	4	-	27760321	HT29	viability after 19 days	TTCCAACCTACCTGGCATCTGG	SMAD1	ENSG00000170365	0.6135785012432775	[800,624]	[1486,1108,1173]	6	hSpCas9	negative selection	5108906
145539856	145539878	4	-	27760321	HT29	viability after 16 days	GTTACGGAACTGAGCTAAGAGG	SMAD1	ENSG00000170365	0.06518596511426678	[206,161]	[236,251,159]	0	hSpCas9	negative selection	5192368
145540051	145540073	4	-	27760321	HT29	viability after 16 days	TTCCAACCTACCTGGCATCTGG	SMAD1	ENSG00000170365	0.39963892493894204	[800,624]	[1144,1032,987]	4	hSpCas9	negative selection	5192369
145539856	145539878	4	-	27760321	HT29	viability after 13 days	GTTACGGAACTGAGCTAAGAGG	SMAD1	ENSG00000170365	-0.19218108697374414	[206,161]	[158,195,205]	-2	hSpCas9	negative selection	5275831
145540051	145540073	4	-	27760321	HT29	viability after 13 days	TTCCAACCTACCTGGCATCTGG	SMAD1	ENSG00000170365	0.502005566440918	[800,624]	[1388,979,1145]	6	hSpCas9	negative selection	5275832
145539856	145539878	4	-	27760321	HT29	viability after 10 days	GTTACGGAACTGAGCTAAGAGG	SMAD1	ENSG00000170365	0.3844771195927319	[206,161]	[330,402,173]	5	hSpCas9	negative selection	5359294
145540051	145540073	4	-	27760321	HT29	viability after 10 days	TTCCAACCTACCTGGCATCTGG	SMAD1	ENSG00000170365	0.37840045330157346	[800,624]	[1188,1135,1145]	5	hSpCas9	negative selection	5359295
145539856	145539878	4	-	27760321	MOLM13	viability	GTTACGGAACTGAGCTAAGAGG	SMAD1	ENSG00000170365	2.200345181250767	[239,206]	[235,868]	9	hSpCas9	negative selection	5442757
145540051	145540073	4	-	27760321	MOLM13	viability	TTCCAACCTACCTGGCATCTGG	SMAD1	ENSG00000170365	0.7233716956742201	[893,800]	[828,753]	5	hSpCas9	negative selection	5442758
145482241	145482264	4	+	27661255	K562	viability	GGCGCCTCCCGTCTGCTCGGAGG	SMAD1	ENSG00000170365	-0.0007690861081000866	[624,792]	[615,518]	0	dCas9-KRAB	negative selection	5512776
145482277	145482300	4	-	27661255	K562	viability	GGGCTGGGCGCGAGAAGACGTGG	SMAD1	ENSG00000170365	-0.07266412235839648	[553,677]	[591,358]	-3	dCas9-KRAB	negative selection	5512777
145539860	145539883	4	+	27260156	BXPC3	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.07807070139297898	[517]	[514,552,598,630]	1	hSpCas9	negative selection	5571658
145546755	145546778	4	+	27260156	BXPC3	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.06762162538506056	[770]	[819,798,849,918]	1	hSpCas9	negative selection	5571659
145554019	145554042	4	+	27260156	BXPC3	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.29465025120611904	[795]	[608,634,680,810]	-6	hSpCas9	negative selection	5571660
145546831	145546854	4	-	27260156	BXPC3	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	0.03712919679140736	[99]	[152,89,87,90]	0	hSpCas9	negative selection	5635911
145539812	145539835	4	-	27260156	BXPC3	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	0.008079968000717752	[802]	[764,768,937,923]	0	hSpCas9	negative selection	5635912
145542644	145542667	4	-	27260156	BXPC3	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.0584751587491632	[793]	[921,833,864,820]	1	hSpCas9	negative selection	5635913
145539860	145539883	4	+	27260156	A673	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	-0.047305248760067115	[517]	[704,543,556,614]	-1	hSpCas9	negative selection	5692909
145546755	145546778	4	+	27260156	A673	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.13719670341404278	[770]	[1111,912,1081,973]	3	hSpCas9	negative selection	5692910
145554019	145554042	4	+	27260156	A673	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.11501908710124098	[795]	[895,798,814,1030]	-3	hSpCas9	negative selection	5692911
145546831	145546854	4	-	27260156	A673	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	0.27206957432816115	[99]	[167,171,97,143]	6	hSpCas9	negative selection	5757162
145539812	145539835	4	-	27260156	A673	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	-0.08482067831523932	[802]	[884,846,798,1114]	-2	hSpCas9	negative selection	5757163
145542644	145542667	4	-	27260156	A673	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.09841542351555366	[793]	[1108,957,897,1134]	2	hSpCas9	negative selection	5757164
145539860	145539883	4	+	27260156	A375	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.12063835888830488	[517]	[703,1016,476,499]	1	hSpCas9	negative selection	5814160
145546755	145546778	4	+	27260156	A375	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.07853516569353636	[770]	[945,824,1084,928]	1	hSpCas9	negative selection	5814161
145554019	145554042	4	+	27260156	A375	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.038277902690703525	[795]	[994,1062,856,744]	0	hSpCas9	negative selection	5814162
145546831	145546854	4	-	27260156	A375	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	0.5490696193201423	[99]	[176,217,118,174]	7	hSpCas9	negative selection	5878413
145539812	145539835	4	-	27260156	A375	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	0.11462346898226572	[802]	[1324,1047,1002,723]	1	hSpCas9	negative selection	5878414
145542644	145542667	4	-	27260156	A375	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.1561391814017863	[793]	[1134,1245,968,833]	2	hSpCas9	negative selection	5878415
145539860	145539883	4	+	27260156	COLO741	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.076091550556182	[517]	[819,588,692]	1	hSpCas9	negative selection	5935411
145546755	145546778	4	+	27260156	COLO741	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.000774253157980076	[770]	[1141,1053,786]	0	hSpCas9	negative selection	5935412
145554019	145554042	4	+	27260156	COLO741	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	0.05793171218020576	[795]	[1079,1042,1052]	1	hSpCas9	negative selection	5935413
145546831	145546854	4	-	27260156	COLO741	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.6593744688366612	[99]	[112,34,95]	-8	hSpCas9	negative selection	5999664
145539812	145539835	4	-	27260156	COLO741	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	-0.029621057182113164	[802]	[1106,900,1012]	0	hSpCas9	negative selection	5999665
145542644	145542667	4	-	27260156	COLO741	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	-0.04366658827814063	[793]	[1006,996,950]	-1	hSpCas9	negative selection	5999666
145539860	145539883	4	+	27260156	CAL120	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	-0.13264089429147435	[517]	[685,480,610]	-2	hSpCas9	negative selection	6056662
145546755	145546778	4	+	27260156	CAL120	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.18657355015826915	[770]	[1203,1216,874]	2	hSpCas9	negative selection	6056663
145554019	145554042	4	+	27260156	CAL120	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.4100563281209519	[795]	[918,753,591]	-5	hSpCas9	negative selection	6056664
145546831	145546854	4	-	27260156	CAL120	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.7401649806303863	[99]	[110,45,71]	-8	hSpCas9	negative selection	6120915
145539812	145539835	4	-	27260156	CAL120	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	0.42171182508000704	[802]	[1386,1282,1351]	6	hSpCas9	negative selection	6120916
145542644	145542667	4	-	27260156	CAL120	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.3062623935691533	[793]	[1588,802,1325]	4	hSpCas9	negative selection	6120917
145539860	145539883	4	+	27260156	CADOES1	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.14995662547301458	[517]	[463,669,409,596]	2	hSpCas9	negative selection	6177913
145546755	145546778	4	+	27260156	CADOES1	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	-0.01796489482919239	[770]	[780,597,652,803]	0	hSpCas9	negative selection	6177914
145554019	145554042	4	+	27260156	CADOES1	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.18292475676359843	[795]	[706,643,541,717]	-3	hSpCas9	negative selection	6177915
145546831	145546854	4	-	27260156	CADOES1	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.23589097694557637	[99]	[40,70,47,158]	-4	hSpCas9	negative selection	6242166
145539812	145539835	4	-	27260156	CADOES1	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	-0.025974720190966694	[802]	[619,728,680,910]	0	hSpCas9	negative selection	6242167
145542644	145542667	4	-	27260156	CADOES1	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.2468226676593006	[793]	[732,864,1115,787]	4	hSpCas9	negative selection	6242168
145539860	145539883	4	+	27260156	EWS502	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	-0.0357877191515643	[517]	[476,392,726,558]	0	hSpCas9	negative selection	6299164
145546755	145546778	4	+	27260156	EWS502	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.04302717019496405	[770]	[783,892,849,839]	0	hSpCas9	negative selection	6299165
145554019	145554042	4	+	27260156	EWS502	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.21730994867457376	[795]	[587,587,1045,700]	-4	hSpCas9	negative selection	6299166
145546831	145546854	4	-	27260156	EWS502	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.6267061174218722	[99]	[55,63,40,117]	-7	hSpCas9	negative selection	6363417
145539812	145539835	4	-	27260156	EWS502	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	-0.1531258031891456	[802]	[632,697,793,964]	-3	hSpCas9	negative selection	6363418
145542644	145542667	4	-	27260156	EWS502	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.1491289866187866	[793]	[800,820,1016,1122]	2	hSpCas9	negative selection	6363419
145539860	145539883	4	+	27260156	EW8	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.2544834304450727	[517]	[834,434,247,562]	4	hSpCas9	negative selection	6420415
145546755	145546778	4	+	27260156	EW8	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	-0.07132656546583194	[770]	[665,548,586,583]	-1	hSpCas9	negative selection	6420416
145554019	145554042	4	+	27260156	EW8	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.33573414798421947	[795]	[550,468,452,583]	-6	hSpCas9	negative selection	6420417
145546831	145546854	4	-	27260156	EW8	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	0.12527218288014863	[99]	[36,99,61,152]	2	hSpCas9	negative selection	6484668
145539812	145539835	4	-	27260156	EW8	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	-0.06440956858059976	[802]	[762,598,515,642]	-1	hSpCas9	negative selection	6484669
145542644	145542667	4	-	27260156	EW8	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.24476394040302019	[793]	[764,815,757,709]	4	hSpCas9	negative selection	6484670
145539860	145539883	4	+	27260156	CORL105	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	-0.00920653106957292	[517]	[597,559,661,599]	0	hSpCas9	negative selection	6541666
145546755	145546778	4	+	27260156	CORL105	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	-0.08246255473071529	[770]	[1000,832,817,757]	-1	hSpCas9	negative selection	6541667
145554019	145554042	4	+	27260156	CORL105	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.2356005459175391	[795]	[761,782,862,767]	-4	hSpCas9	negative selection	6541668
145546831	145546854	4	-	27260156	CORL105	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	0.15870854557350755	[99]	[130,126,150,116]	3	hSpCas9	negative selection	6605919
145539812	145539835	4	-	27260156	CORL105	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	0.07940126968655692	[802]	[1061,808,1379,788]	1	hSpCas9	negative selection	6605920
145542644	145542667	4	-	27260156	CORL105	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.2069628397650033	[793]	[1116,965,1237,999]	4	hSpCas9	negative selection	6605921
145539860	145539883	4	+	27260156	HS294T	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.2506881882687372	[517]	[262,172,243,278]	3	hSpCas9	negative selection	6662917
145546755	145546778	4	+	27260156	HS294T	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.2354361785881639	[770]	[360,248,379,427]	3	hSpCas9	negative selection	6662918
145554019	145554042	4	+	27260156	HS294T	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.10195572626287308	[795]	[231,175,291,488]	-1	hSpCas9	negative selection	6662919
145546831	145546854	4	-	27260156	HS294T	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	0.7851098550411804	[99]	[160,36,28,23]	8	hSpCas9	negative selection	6727170
145539812	145539835	4	-	27260156	HS294T	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	0.6061563800759197	[802]	[708,487,321,320]	7	hSpCas9	negative selection	6727171
145542644	145542667	4	-	27260156	HS294T	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	-0.08653923881749948	[793]	[196,351,280,340]	-1	hSpCas9	negative selection	6727172
145539860	145539883	4	+	27260156	HCC44	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.2671446467308405	[517]	[669,588,867,727]	4	hSpCas9	negative selection	6784168
145546755	145546778	4	+	27260156	HCC44	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.3020294002865346	[770]	[1153,873,1428,935]	5	hSpCas9	negative selection	6784169
145554019	145554042	4	+	27260156	HCC44	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	0.013546095567654293	[795]	[1173,607,704,1163]	0	hSpCas9	negative selection	6784170
145546831	145546854	4	-	27260156	HCC44	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	0.10126600161410604	[99]	[52,105,152,171]	1	hSpCas9	negative selection	6848421
145539812	145539835	4	-	27260156	HCC44	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	0.3049047286484735	[802]	[1117,889,1348,1190]	5	hSpCas9	negative selection	6848422
145542644	145542667	4	-	27260156	HCC44	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.06517456938334798	[793]	[902,948,913,973]	1	hSpCas9	negative selection	6848423
145539860	145539883	4	+	27260156	G402	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.026978624337798796	[517]	[604,640,832,495]	0	hSpCas9	negative selection	6905419
145546755	145546778	4	+	27260156	G402	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.06188679594884261	[770]	[651,1032,1158,1032]	0	hSpCas9	negative selection	6905420
145554019	145554042	4	+	27260156	G402	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	0.1717047066955476	[795]	[1148,1380,591,1265]	2	hSpCas9	negative selection	6905421
145546831	145546854	4	-	27260156	G402	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.21320801625464192	[99]	[29,6,154,206]	-3	hSpCas9	negative selection	6969672
145539812	145539835	4	-	27260156	G402	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	0.18069635935448447	[802]	[900,1602,836,1095]	2	hSpCas9	negative selection	6969673
145542644	145542667	4	-	27260156	G402	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.15541806982791662	[793]	[1235,941,885,1253]	2	hSpCas9	negative selection	6969674
145539860	145539883	4	+	27260156	L33	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.0842081306146204	[517]	[448,245,325,629]	1	hSpCas9	negative selection	7026670
145546755	145546778	4	+	27260156	L33	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.3752260067500831	[770]	[837,420,664,1079]	7	hSpCas9	negative selection	7026671
145554019	145554042	4	+	27260156	L33	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.26260910386750286	[795]	[610,255,434,726]	-6	hSpCas9	negative selection	7026672
145546831	145546854	4	-	27260156	L33	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	0.22436782496455265	[99]	[137,55,55,102]	5	hSpCas9	negative selection	7090923
145539812	145539835	4	-	27260156	L33	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	-0.2557543030881003	[802]	[779,249,448,583]	-5	hSpCas9	negative selection	7090924
145542644	145542667	4	-	27260156	L33	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.18421671509538873	[793]	[878,375,642,790]	4	hSpCas9	negative selection	7090925
145539860	145539883	4	+	27260156	K562	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.36971478703716054	[517]	[469,570,585,719]	4	hSpCas9	negative selection	7147921
145546755	145546778	4	+	27260156	K562	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.16665723188549364	[770]	[906,831,779,585]	2	hSpCas9	negative selection	7147922
145554019	145554042	4	+	27260156	K562	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.15614543885541976	[795]	[490,674,671,679]	-2	hSpCas9	negative selection	7147923
145546831	145546854	4	-	27260156	K562	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.6673047027691998	[99]	[91,41,77,17]	-7	hSpCas9	negative selection	7212174
145539812	145539835	4	-	27260156	K562	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	0.00753026468992235	[802]	[568,547,598,1081]	0	hSpCas9	negative selection	7212175
145542644	145542667	4	-	27260156	K562	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.6082448691906244	[793]	[1306,850,1743,468]	7	hSpCas9	negative selection	7212176
145539860	145539883	4	+	27260156	HT29	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	-0.05680864104869403	[517]	[719,691,475,551]	-1	hSpCas9	negative selection	7269172
145546755	145546778	4	+	27260156	HT29	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	-0.05776487025147192	[770]	[1030,1010,871,722]	-1	hSpCas9	negative selection	7269173
145554019	145554042	4	+	27260156	HT29	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.20606130382321608	[795]	[1101,860,727,697]	-4	hSpCas9	negative selection	7269174
145546831	145546854	4	-	27260156	HT29	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.326605355613113	[99]	[126,98,52,108]	-6	hSpCas9	negative selection	7333425
145539812	145539835	4	-	27260156	HT29	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	-0.012612926960053783	[802]	[1227,783,1033,837]	0	hSpCas9	negative selection	7333426
145542644	145542667	4	-	27260156	HT29	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.08817586611939487	[793]	[1143,1166,1033,800]	1	hSpCas9	negative selection	7333427
145539860	145539883	4	+	27260156	MHHES1	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.28096915732861644	[517]	[571,1010,793,504]	5	hSpCas9	negative selection	7390423
145546755	145546778	4	+	27260156	MHHES1	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	-0.11356989408087126	[770]	[1091,882,593,690]	-2	hSpCas9	negative selection	7390424
145554019	145554042	4	+	27260156	MHHES1	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.6550009725275399	[795]	[679,381,597,592]	-8	hSpCas9	negative selection	7390425
145546831	145546854	4	-	27260156	MHHES1	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.5055611809234772	[99]	[72,129,89,36]	-7	hSpCas9	negative selection	7454676
145539812	145539835	4	-	27260156	MHHES1	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	0.02176608410354519	[802]	[988,849,1018,818]	0	hSpCas9	negative selection	7454677
145542644	145542667	4	-	27260156	MHHES1	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.20786525852819926	[793]	[1123,1076,1485,552]	4	hSpCas9	negative selection	7454678
145539860	145539883	4	+	27260156	MEWO	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.22735915568718318	[517]	[466,660,553]	5	hSpCas9	negative selection	7511674
145546755	145546778	4	+	27260156	MEWO	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.21000773765668723	[770]	[990,669,872]	4	hSpCas9	negative selection	7511675
145554019	145554042	4	+	27260156	MEWO	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.5123891778374342	[795]	[574,396,604]	-8	hSpCas9	negative selection	7511676
145546831	145546854	4	-	27260156	MEWO	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.5573969290684593	[99]	[58,26,103]	-8	hSpCas9	negative selection	7575927
145539812	145539835	4	-	27260156	MEWO	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	0.029090099058431074	[802]	[975,782,580]	0	hSpCas9	negative selection	7575928
145542644	145542667	4	-	27260156	MEWO	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.17069382870081928	[793]	[1072,653,827]	4	hSpCas9	negative selection	7575929
145539860	145539883	4	+	27260156	LNCAPCLONEFGC	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	-0.15752595071501035	[517]	[341,477,317,526]	-3	hSpCas9	negative selection	7632925
145546755	145546778	4	+	27260156	LNCAPCLONEFGC	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	-0.0847966793456919	[770]	[624,801,638,555]	-1	hSpCas9	negative selection	7632926
145554019	145554042	4	+	27260156	LNCAPCLONEFGC	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.19612718818700714	[795]	[751,497,625,646]	-3	hSpCas9	negative selection	7632927
145546831	145546854	4	-	27260156	LNCAPCLONEFGC	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	0.28245531424571224	[99]	[136,118,45,127]	4	hSpCas9	negative selection	7697178
145539812	145539835	4	-	27260156	LNCAPCLONEFGC	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	0.02093540291434104	[802]	[902,673,800,583]	0	hSpCas9	negative selection	7697179
145542644	145542667	4	-	27260156	LNCAPCLONEFGC	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.02199847522402698	[793]	[660,543,902,851]	0	hSpCas9	negative selection	7697180
145539860	145539883	4	+	27260156	PANC0327	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.3089578741405338	[517]	[326,1078,334,452]	4	hSpCas9	negative selection	7754176
145546755	145546778	4	+	27260156	PANC0327	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.35140527498406093	[770]	[1195,727,797,817]	5	hSpCas9	negative selection	7754177
145554019	145554042	4	+	27260156	PANC0327	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.35069026603535985	[795]	[916,507,223,603]	-5	hSpCas9	negative selection	7754178
145546831	145546854	4	-	27260156	PANC0327	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	0.014355048134556014	[99]	[21,23,220,94]	0	hSpCas9	negative selection	7818429
145539812	145539835	4	-	27260156	PANC0327	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	0.18713735355740002	[802]	[895,721,948,699]	2	hSpCas9	negative selection	7818430
145542644	145542667	4	-	27260156	PANC0327	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.16002823802920008	[793]	[511,592,695,1352]	2	hSpCas9	negative selection	7818431
145539860	145539883	4	+	27260156	NCIH2009	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	-0.07527790369557052	[517]	[675,822,555]	-1	hSpCas9	negative selection	7875427
145546755	145546778	4	+	27260156	NCIH2009	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.13899429923312168	[770]	[1369,953,1272]	2	hSpCas9	negative selection	7875428
145554019	145554042	4	+	27260156	NCIH2009	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.17943482100567043	[795]	[1471,837,733]	-2	hSpCas9	negative selection	7875429
145546831	145546854	4	-	27260156	NCIH2009	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.8858911194631793	[99]	[68,96,58]	-8	hSpCas9	negative selection	7939680
145539812	145539835	4	-	27260156	NCIH2009	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	0.4757702021684781	[802]	[1988,1599,1172]	6	hSpCas9	negative selection	7939681
145542644	145542667	4	-	27260156	NCIH2009	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.22208196130916424	[793]	[1630,868,1453]	3	hSpCas9	negative selection	7939682
145539860	145539883	4	+	27260156	NCIH1373	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.07757420757172295	[517]	[385,680,606,193]	0	hSpCas9	negative selection	7996678
145546755	145546778	4	+	27260156	NCIH1373	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.2554278372961646	[770]	[868,749,1455,273]	2	hSpCas9	negative selection	7996679
145554019	145554042	4	+	27260156	NCIH1373	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.6792649424493862	[795]	[657,417,703,122]	-6	hSpCas9	negative selection	7996680
145546831	145546854	4	-	27260156	NCIH1373	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.06978419045989126	[99]	[119,127,33,38]	0	hSpCas9	negative selection	8060931
145539812	145539835	4	-	27260156	NCIH1373	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	0.33402137882817107	[802]	[1690,1142,1275,121]	3	hSpCas9	negative selection	8060932
145542644	145542667	4	-	27260156	NCIH1373	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.2358362448291469	[793]	[882,1542,848,215]	2	hSpCas9	negative selection	8060933
145539860	145539883	4	+	27260156	PATU8902	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.5289230351046532	[517]	[1037,791,598,1948]	5	hSpCas9	negative selection	8117929
145546755	145546778	4	+	27260156	PATU8902	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.2367558432526452	[770]	[1474,1218,907,1575]	2	hSpCas9	negative selection	8117930
145554019	145554042	4	+	27260156	PATU8902	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	0.2639994855842144	[795]	[1246,1185,965,2102]	2	hSpCas9	negative selection	8117931
145546831	145546854	4	-	27260156	PATU8902	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	0.90269633999046	[99]	[184,397,260,187]	8	hSpCas9	negative selection	8182182
145539812	145539835	4	-	27260156	PATU8902	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	0.35366758597688863	[802]	[1580,1464,1155,1590]	3	hSpCas9	negative selection	8182183
145542644	145542667	4	-	27260156	PATU8902	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.48825694463207414	[793]	[994,1771,1968,1328]	5	hSpCas9	negative selection	8182184
145539860	145539883	4	+	27260156	PANC1	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	-0.144378216009262	[517]	[430,455,256,458]	-2	hSpCas9	negative selection	8239180
145546755	145546778	4	+	27260156	PANC1	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	-0.0014370868583070129	[770]	[773,718,620,548]	0	hSpCas9	negative selection	8239181
145554019	145554042	4	+	27260156	PANC1	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.2956368621746045	[795]	[641,862,354,437]	-5	hSpCas9	negative selection	8239182
145546831	145546854	4	-	27260156	PANC1	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	0.027176683750586683	[99]	[48,120,95,89]	0	hSpCas9	negative selection	8303433
145539812	145539835	4	-	27260156	PANC1	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	-0.08933292087782818	[802]	[753,737,682,455]	-1	hSpCas9	negative selection	8303434
145542644	145542667	4	-	27260156	PANC1	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.046966447080622364	[793]	[701,1046,682,481]	0	hSpCas9	negative selection	8303435
145539860	145539883	4	+	27260156	PANC0813	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.2611342611165347	[517]	[842,789,798,506]	4	hSpCas9	negative selection	8360431
145546755	145546778	4	+	27260156	PANC0813	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.25604932780379575	[770]	[1195,894,1275,974]	4	hSpCas9	negative selection	8360432
145554019	145554042	4	+	27260156	PANC0813	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.27228742936034217	[795]	[859,820,736,689]	-4	hSpCas9	negative selection	8360433
145546831	145546854	4	-	27260156	PANC0813	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.36051312563708615	[99]	[49,144,111,56]	-5	hSpCas9	negative selection	8424684
145539812	145539835	4	-	27260156	PANC0813	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	-0.06399720325528613	[802]	[1062,964,887,716]	-1	hSpCas9	negative selection	8424685
145542644	145542667	4	-	27260156	PANC0813	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.09300811668225684	[793]	[872,868,1240,984]	1	hSpCas9	negative selection	8424686
145539860	145539883	4	+	27260156	RDES	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	-0.2115116558531594	[517]	[400,507,668,491]	-4	hSpCas9	negative selection	8481682
145546755	145546778	4	+	27260156	RDES	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.05519324653021118	[770]	[647,682,1006,1495]	0	hSpCas9	negative selection	8481683
145554019	145554042	4	+	27260156	RDES	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.24728933492408423	[795]	[617,729,744,1046]	-4	hSpCas9	negative selection	8481684
145546831	145546854	4	-	27260156	RDES	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.7906912778868169	[99]	[58,67,74,62]	-8	hSpCas9	negative selection	8545935
145539812	145539835	4	-	27260156	RDES	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	-0.04913296809151102	[802]	[789,831,1002,958]	-1	hSpCas9	negative selection	8545936
145542644	145542667	4	-	27260156	RDES	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.13894582596481397	[793]	[772,796,1290,1250]	2	hSpCas9	negative selection	8545937
145539860	145539883	4	+	27260156	PC3	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	-0.27471150043759496	[517]	[242,410,629,550]	-6	hSpCas9	negative selection	8602933
145546755	145546778	4	+	27260156	PC3	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.18372426155860888	[770]	[682,777,1428,799]	4	hSpCas9	negative selection	8602934
145554019	145554042	4	+	27260156	PC3	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.359239177927197	[795]	[464,595,885,628]	-7	hSpCas9	negative selection	8602935
145546831	145546854	4	-	27260156	PC3	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.8895417100139733	[99]	[34,37,125,47]	-9	hSpCas9	negative selection	8667186
145539812	145539835	4	-	27260156	PC3	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	0.17210289883735053	[802]	[573,825,1595,942]	4	hSpCas9	negative selection	8667187
145542644	145542667	4	-	27260156	PC3	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.1765118449340567	[793]	[525,877,1309,1114]	4	hSpCas9	negative selection	8667188
145539860	145539883	4	+	27260156	PATU8988T	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	-0.401267694420074	[517]	[451,192,416,440]	-6	hSpCas9	negative selection	8724184
145546755	145546778	4	+	27260156	PATU8988T	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	-0.039948398107904515	[770]	[633,896,645,739]	0	hSpCas9	negative selection	8724185
145554019	145554042	4	+	27260156	PATU8988T	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	0.13171429051163397	[795]	[798,928,663,1001]	2	hSpCas9	negative selection	8724186
145546831	145546854	4	-	27260156	PATU8988T	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	0.6828286774539927	[99]	[245,79,129,157]	9	hSpCas9	negative selection	8788437
145539812	145539835	4	-	27260156	PATU8988T	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	0.015360718888091207	[802]	[669,756,787,930]	0	hSpCas9	negative selection	8788438
145542644	145542667	4	-	27260156	PATU8988T	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.44292855549355936	[793]	[1447,919,842,943]	7	hSpCas9	negative selection	8788439
145539860	145539883	4	+	27260156	T47D	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	-0.20868964470820014	[517]	[592,498,509,487]	-4	hSpCas9	negative selection	8845435
145546755	145546778	4	+	27260156	T47D	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	-0.007697900452487971	[770]	[901,831,947,895]	0	hSpCas9	negative selection	8845436
145554019	145554042	4	+	27260156	T47D	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.2487969062105072	[795]	[789,709,797,830]	-5	hSpCas9	negative selection	8845437
145546831	145546854	4	-	27260156	T47D	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.08366356769402516	[99]	[64,70,145,161]	-2	hSpCas9	negative selection	8909688
145539812	145539835	4	-	27260156	T47D	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	-0.13995472524488184	[802]	[811,818,877,889]	-3	hSpCas9	negative selection	8909689
145542644	145542667	4	-	27260156	T47D	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.19882077744863358	[793]	[1164,951,997,1144]	4	hSpCas9	negative selection	8909690
145539860	145539883	4	+	27260156	SU8686	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	-0.06478789998446047	[517]	[467,457,470,584]	-1	hSpCas9	negative selection	8966686
145546755	145546778	4	+	27260156	SU8686	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.17069375609571014	[770]	[920,676,847,1033]	3	hSpCas9	negative selection	8966687
145554019	145554042	4	+	27260156	SU8686	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.20018496639291838	[795]	[691,582,588,927]	-3	hSpCas9	negative selection	8966688
145546831	145546854	4	-	27260156	SU8686	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.1394092450391713	[99]	[92,57,154,52]	-2	hSpCas9	negative selection	9030939
145539812	145539835	4	-	27260156	SU8686	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	-0.061293247692961184	[802]	[642,806,684,946]	-1	hSpCas9	negative selection	9030940
145542644	145542667	4	-	27260156	SU8686	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.16320968704956385	[793]	[812,779,1006,955]	2	hSpCas9	negative selection	9030941
145539860	145539883	4	+	27260156	SKES1	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	-0.08212485250552881	[517]	[557,629,418,380]	-2	hSpCas9	negative selection	9087937
145546755	145546778	4	+	27260156	SKES1	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	-0.0460347482397514	[770]	[1207,746,541,563]	-1	hSpCas9	negative selection	9087938
145554019	145554042	4	+	27260156	SKES1	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.1825728780390924	[795]	[779,864,499,681]	-4	hSpCas9	negative selection	9087939
145546831	145546854	4	-	27260156	SKES1	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.0460286459951309	[99]	[178,130,74,24]	-1	hSpCas9	negative selection	9152190
145539812	145539835	4	-	27260156	SKES1	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	-0.2104205283417775	[802]	[943,819,509,556]	-4	hSpCas9	negative selection	9152191
145542644	145542667	4	-	27260156	SKES1	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.19360841113278282	[793]	[1204,856,786,812]	4	hSpCas9	negative selection	9152192
145539860	145539883	4	+	27260156	TOV112D	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	0.037135134088116833	[517]	[454,579,469,625]	0	hSpCas9	negative selection	9209188
145546755	145546778	4	+	27260156	TOV112D	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.12015394559686077	[770]	[873,812,1002,666]	2	hSpCas9	negative selection	9209189
145554019	145554042	4	+	27260156	TOV112D	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	0.20896615544075314	[795]	[915,1586,685,665]	4	hSpCas9	negative selection	9209190
145546831	145546854	4	-	27260156	TOV112D	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.002674478128625868	[99]	[153,182,34,53]	0	hSpCas9	negative selection	9273441
145539812	145539835	4	-	27260156	TOV112D	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	-0.003935308032518181	[802]	[1016,1062,580,632]	0	hSpCas9	negative selection	9273442
145542644	145542667	4	-	27260156	TOV112D	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.33219219720481585	[793]	[846,1230,1058,911]	6	hSpCas9	negative selection	9273443
145539860	145539883	4	+	27260156	TC71	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	-0.015529427344814953	[517]	[659,464,537,530]	0	hSpCas9	negative selection	9330439
145546755	145546778	4	+	27260156	TC71	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	0.04942468384520016	[770]	[873,757,742,1061]	1	hSpCas9	negative selection	9330440
145554019	145554042	4	+	27260156	TC71	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.23696671937973812	[795]	[748,623,776,744]	-6	hSpCas9	negative selection	9330441
145546831	145546854	4	-	27260156	TC71	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.49258264787036943	[99]	[75,101,56,69]	-8	hSpCas9	negative selection	9394692
145539812	145539835	4	-	27260156	TC71	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	-0.40011077576576165	[802]	[732,598,496,791]	-8	hSpCas9	negative selection	9394693
145542644	145542667	4	-	27260156	TC71	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.13534546264460978	[793]	[869,932,1005,928]	3	hSpCas9	negative selection	9394694
145539860	145539883	4	+	27260156	TC32	viability	TTAGCTCAGTTCCGTAACTTAGG	SMAD1	ENSG00000170365	-0.43676153486099356	[517]	[383,167,588,388]	-7	hSpCas9	negative selection	9451690
145546755	145546778	4	+	27260156	TC32	viability	CTATGAGCTCAACAATCGTGTGG	SMAD1	ENSG00000170365	-0.36166781956997496	[770]	[558,368,911,514]	-6	hSpCas9	negative selection	9451691
145554019	145554042	4	+	27260156	TC32	viability	TATACGTATGAGCTTTGTGAAGG	SMAD1	ENSG00000170365	-0.08889283496212719	[795]	[607,636,818,765]	-1	hSpCas9	negative selection	9451692
145546831	145546854	4	-	27260156	TC32	viability	AAACGGTTCTTATTGTTGGAAGG	SMAD1	ENSG00000170365	-0.34437441906957256	[99]	[92,45,125,41]	-6	hSpCas9	negative selection	9515943
145539812	145539835	4	-	27260156	TC32	viability	CTGTGTCTTGGAACCAGCACAGG	SMAD1	ENSG00000170365	-0.020112979728123648	[802]	[536,750,786,893]	0	hSpCas9	negative selection	9515944
145542644	145542667	4	-	27260156	TC32	viability	GCCATCATGTTTGTGTCCATCGG	SMAD1	ENSG00000170365	0.19327090697743254	[793]	[781,624,1061,1034]	3	hSpCas9	negative selection	9515945
145542628	145542651	4	+	27869803	HPAFII	viability after 27 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	0.4281312594052714	[296]	[238,185,NaN]	3	hSpCas9	negative selection	9587074
145542674	145542697	4	+	27869803	HPAFII	viability after 27 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.3277799782940818	[692]	[681,269,NaN]	2	hSpCas9	negative selection	9587075
145546793	145546816	4	-	27869803	HPAFII	viability after 27 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	-0.5352417534623678	[425]	[87,209,NaN]	-4	hSpCas9	negative selection	9587076
145557808	145557831	4	-	27869803	HPAFII	viability after 27 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	0.4564447316059388	[525]	[331,418,NaN]	3	hSpCas9	negative selection	9587077
145542628	145542651	4	+	27869803	HPAFII	viability after 15 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	0.49370810189259384	[296]	[573,371,NaN]	5	hSpCas9	negative selection	9669523
145542674	145542697	4	+	27869803	HPAFII	viability after 15 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.01780925745731632	[692]	[1160,500,NaN]	0	hSpCas9	negative selection	9669524
145546793	145546816	4	-	27869803	HPAFII	viability after 15 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	0.37861447381334945	[425]	[712,521,NaN]	4	hSpCas9	negative selection	9669525
145557808	145557831	4	-	27869803	HPAFII	viability after 15 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	0.03756505102220098	[525]	[972,335,NaN]	0	hSpCas9	negative selection	9669526
145542628	145542651	4	+	27869803	ASPC1	viability after 36 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	0.6826115162266597	[589]	[381,516,142]	6	hSpCas9	negative selection	9751972
145542674	145542697	4	+	27869803	ASPC1	viability after 36 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.6487713220160941	[1247]	[546,996,521]	6	hSpCas9	negative selection	9751973
145546793	145546816	4	-	27869803	ASPC1	viability after 36 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	0.03449791787989409	[1120]	[701,225,323]	0	hSpCas9	negative selection	9751974
145557808	145557831	4	-	27869803	ASPC1	viability after 36 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	0.566219362880446	[1211]	[1141,613,267]	5	hSpCas9	negative selection	9751975
145542628	145542651	4	+	27869803	PATU8988S	viability after 35 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	0.750067562040128	[579]	[557,226,NaN]	7	hSpCas9	negative selection	9834421
145542674	145542697	4	+	27869803	PATU8988S	viability after 35 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	-0.3422020354264701	[1359]	[465,397,NaN]	-4	hSpCas9	negative selection	9834422
145546793	145546816	4	-	27869803	PATU8988S	viability after 35 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	0.39775204475686077	[913]	[691,276,NaN]	4	hSpCas9	negative selection	9834423
145557808	145557831	4	-	27869803	PATU8988S	viability after 35 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	0.044146543617397116	[1091]	[439,466,NaN]	0	hSpCas9	negative selection	9834424
145542628	145542651	4	+	27869803	PATU8988S	viability after 31 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	0.6935050429990204	[579]	[439,289,NaN]	7	hSpCas9	negative selection	9916870
145542674	145542697	4	+	27869803	PATU8988S	viability after 31 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	-0.34112812528690606	[1359]	[318,566,NaN]	-4	hSpCas9	negative selection	9916871
145546793	145546816	4	-	27869803	PATU8988S	viability after 31 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	0.37818661380601837	[913]	[474,471,NaN]	4	hSpCas9	negative selection	9916872
145557808	145557831	4	-	27869803	PATU8988S	viability after 31 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	0.016422307011234816	[1091]	[307,608,NaN]	0	hSpCas9	negative selection	9916873
145542628	145542651	4	+	27869803	HPAFII	viability after 35 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	0.4853510386939255	[296]	[241,174,NaN]	3	hSpCas9	negative selection	9999319
145542674	145542697	4	+	27869803	HPAFII	viability after 35 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.6324938959015431	[692]	[755,304,NaN]	4	hSpCas9	negative selection	9999320
145546793	145546816	4	-	27869803	HPAFII	viability after 35 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	-0.5581951039342368	[425]	[18,289,NaN]	-3	hSpCas9	negative selection	9999321
145557808	145557831	4	-	27869803	HPAFII	viability after 35 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	0.35304679495138425	[525]	[214,480,NaN]	2	hSpCas9	negative selection	9999322
145542628	145542651	4	+	27869803	HPAFII	viability after 31 days	CCAGGATGGCTCTCAGCCGATGG	SMAD1	ENSG00000170365	0.44755128849642234	[296]	[222,231,NaN]	3	hSpCas9	negative selection	10081768
145542674	145542697	4	+	27869803	HPAFII	viability after 31 days	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.5817474582982529	[692]	[717,433,NaN]	4	hSpCas9	negative selection	10081769
145546793	145546816	4	-	27869803	HPAFII	viability after 31 days	CACCAACACACTTGTGGAGGAGG	SMAD1	ENSG00000170365	-0.7183056908054407	[425]	[62,234,NaN]	-5	hSpCas9	negative selection	10081770
145557808	145557831	4	-	27869803	HPAFII	viability after 31 days	TGCTAGTAACATCCTGGCGGTGG	SMAD1	ENSG00000170365	-0.05888820395210481	[525]	[213,358,NaN]	0	hSpCas9	negative selection	10081771
145542674	145542697	4	+	28162770	P31FUJ	viability	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.37266595174141903	[325]	[495]	4	hSpCas9	negative selection	10238707
145539946	145539969	4	-	28162770	P31FUJ	viability	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	0.7510781302223445	[134]	[266]	8	hSpCas9	negative selection	10238708
145539845	145539868	4	-	28162770	P31FUJ	viability	TGAGCTAAGAGGCTGTGCTGAGG	SMAD1	ENSG00000170365	0.2995456701433556	[241]	[349]	3	hSpCas9	negative selection	10238709
145542674	145542697	4	+	28162770	TF1	viability	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	NaN	[NaN]	[365]	1	hSpCas9	negative selection	10408073
145539946	145539969	4	-	28162770	TF1	viability	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	NaN	[NaN]	[112]	1	hSpCas9	negative selection	10408074
145539845	145539868	4	-	28162770	TF1	viability	TGAGCTAAGAGGCTGTGCTGAGG	SMAD1	ENSG00000170365	NaN	[NaN]	[320]	1	hSpCas9	negative selection	10408075
145542674	145542697	4	+	28162770	SKM1	viability	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.43365317744619086	[48]	[116]	4	hSpCas9	negative selection	10577439
145539946	145539969	4	-	28162770	SKM1	viability	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	-0.09118833083739458	[46]	[77]	-1	hSpCas9	negative selection	10577440
145539845	145539868	4	-	28162770	SKM1	viability	TGAGCTAAGAGGCTGTGCTGAGG	SMAD1	ENSG00000170365	-0.9573535509168918	[66]	[60]	-6	hSpCas9	negative selection	10577441
145542674	145542697	4	+	28162770	SKM1	viability	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.43365317744619086	[48]	[116]	4	hSpCas9	negative selection	10746805
145539946	145539969	4	-	28162770	SKM1	viability	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	-0.09118833083739458	[46]	[77]	-1	hSpCas9	negative selection	10746806
145539845	145539868	4	-	28162770	SKM1	viability	TGAGCTAAGAGGCTGTGCTGAGG	SMAD1	ENSG00000170365	-0.9573535509168918	[66]	[60]	-6	hSpCas9	negative selection	10746807
145542674	145542697	4	+	28162770	PL21	viability	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	-0.35537910833935415	[193]	[65]	-3	hSpCas9	negative selection	10916171
145539946	145539969	4	-	28162770	PL21	viability	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	0.9432313114523676	[140]	[117]	7	hSpCas9	negative selection	10916172
145539845	145539868	4	-	28162770	PL21	viability	TGAGCTAAGAGGCTGTGCTGAGG	SMAD1	ENSG00000170365	1.1495135414193522	[144]	[139]	8	hSpCas9	negative selection	10916173
145542674	145542697	4	+	28162770	P31FUJ	viability	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.37266595174141903	[325]	[495]	4	hSpCas9	negative selection	11085537
145539946	145539969	4	-	28162770	P31FUJ	viability	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	0.7510781302223445	[134]	[266]	8	hSpCas9	negative selection	11085538
145539845	145539868	4	-	28162770	P31FUJ	viability	TGAGCTAAGAGGCTGTGCTGAGG	SMAD1	ENSG00000170365	0.2995456701433556	[241]	[349]	3	hSpCas9	negative selection	11085539
145542674	145542697	4	+	28162770	OCIAML5	viability	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	-0.25373330677438194	[178]	[270]	-2	hSpCas9	negative selection	11254903
145539946	145539969	4	-	28162770	OCIAML5	viability	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	0.6463869366024841	[62]	[177]	5	hSpCas9	negative selection	11254904
145539845	145539868	4	-	28162770	OCIAML5	viability	TGAGCTAAGAGGCTGTGCTGAGG	SMAD1	ENSG00000170365	1.0596250110083427	[79]	[300]	8	hSpCas9	negative selection	11254905
145542674	145542697	4	+	28162770	EOL1	viability	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	1.1679533706553955	[184]	[218]	8	hSpCas9	negative selection	11424269
145539946	145539969	4	-	28162770	EOL1	viability	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	0.9104035892502649	[204]	[202]	7	hSpCas9	negative selection	11424270
145539845	145539868	4	-	28162770	EOL1	viability	TGAGCTAAGAGGCTGTGCTGAGG	SMAD1	ENSG00000170365	0.08228723456472914	[250]	[139]	0	hSpCas9	negative selection	11424271
145542674	145542697	4	+	28162770	MOLM13	viability	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	-0.958683148100743	[292]	[108]	-5	hSpCas9	negative selection	11593635
145539946	145539969	4	-	28162770	MOLM13	viability	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	0.2095773859531881	[182]	[152]	1	hSpCas9	negative selection	11593636
145539845	145539868	4	-	28162770	MOLM13	viability	TGAGCTAAGAGGCTGTGCTGAGG	SMAD1	ENSG00000170365	0.3716740662852757	[278]	[260]	2	hSpCas9	negative selection	11593637
145542674	145542697	4	+	28162770	HEL	viability	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	1.0948656500144207	[287]	[393]	8	hSpCas9	negative selection	11763001
145539946	145539969	4	-	28162770	HEL	viability	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	0.48110044174300537	[216]	[193]	4	hSpCas9	negative selection	11763002
145539845	145539868	4	-	28162770	HEL	viability	TGAGCTAAGAGGCTGTGCTGAGG	SMAD1	ENSG00000170365	0.10530470136178662	[208]	[143]	0	hSpCas9	negative selection	11763003
145542674	145542697	4	+	28162770	MV411	viability	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.9363977720381491	[164]	[265]	8	hSpCas9	negative selection	11932367
145539946	145539969	4	-	28162770	MV411	viability	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	0.6748587745174517	[144]	[194]	6	hSpCas9	negative selection	11932368
145539845	145539868	4	-	28162770	MV411	viability	TGAGCTAAGAGGCTGTGCTGAGG	SMAD1	ENSG00000170365	-0.3805936718302668	[186]	[120]	-3	hSpCas9	negative selection	11932369
145542674	145542697	4	+	28162770	MONOMAC1	viability	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	0.0497569177670293	[133]	[158]	0	hSpCas9	negative selection	12101733
145539946	145539969	4	-	28162770	MONOMAC1	viability	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	0.7843474747730993	[77]	[153]	7	hSpCas9	negative selection	12101734
145539845	145539868	4	-	28162770	MONOMAC1	viability	TGAGCTAAGAGGCTGTGCTGAGG	SMAD1	ENSG00000170365	0.8443830803204271	[102]	[211]	7	hSpCas9	negative selection	12101735
145542674	145542697	4	+	28162770	OCIAML2	viability	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	1.5189284280361919	[25]	[412]	9	hSpCas9	negative selection	12271099
145539946	145539969	4	-	28162770	OCIAML2	viability	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	0.685288318206272	[22]	[204]	6	hSpCas9	negative selection	12271100
145539845	145539868	4	-	28162770	OCIAML2	viability	TGAGCTAAGAGGCTGTGCTGAGG	SMAD1	ENSG00000170365	0.5405974301810929	[31]	[257]	5	hSpCas9	negative selection	12271101
145542674	145542697	4	+	28162770	OCIAML3	viability	CTGCCCTCAGAAATCAACAGAGG	SMAD1	ENSG00000170365	2.0399622011334486	[40]	[508]	9	hSpCas9	negative selection	12440465
145539946	145539969	4	-	28162770	OCIAML3	viability	TGGGAGAGTGAGGAAACGGGTGG	SMAD1	ENSG00000170365	-0.6339003674476759	[54]	[106]	-5	hSpCas9	negative selection	12440466
145539845	145539868	4	-	28162770	OCIAML3	viability	TGAGCTAAGAGGCTGTGCTGAGG	SMAD1	ENSG00000170365	-0.8611117104670039	[70]	[117]	-6	hSpCas9	negative selection	12440467