Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:4090
• Symbol:SMAD5
• Description:SMAD family member 5

DataSource: http://genomecrispr.dkfz.de/#!/results/SMAD5

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
136154023	136154046	5	+	26627737	DLD1	viability	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	-1.2046195101987873	[441]	[70,92,22]	-8	hSpCas9	negative selection	826958
136160908	136160931	5	-	26627737	DLD1	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-1.347366902899771	[45]	[11,0,3]	-8	hSpCas9	negative selection	826959
136163283	136163306	5	-	26627737	DLD1	viability	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	0.3382189997200269	[377]	[178,177,99]	3	hSpCas9	negative selection	826960
136163298	136163321	5	-	26627737	DLD1	viability	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	1.2096778704164923	[213]	[292,34,133]	9	hSpCas9	negative selection	826961
136172442	136172465	5	-	26627737	DLD1	viability	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	-0.26470763609386516	[562]	[173,168,103]	-3	hSpCas9	negative selection	826962
136174569	136174592	5	-	26627737	DLD1	viability	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	1.8883306351272253	[54]	[1,41,134]	9	hSpCas9	negative selection	826963
136154023	136154046	5	+	26627737	GBM cells	viability after 5 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	-0.4612616893586401	[85]	[39,26]	-6	hSpCas9	negative selection	909273
136160908	136160931	5	-	26627737	GBM cells	viability after 5 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-1.8138041730338434	[58]	[8,8]	-9	hSpCas9	negative selection	909274
136163283	136163306	5	-	26627737	GBM cells	viability after 5 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	0.014391092305621578	[215]	[156,76]	0	hSpCas9	negative selection	909275
136163298	136163321	5	-	26627737	GBM cells	viability after 5 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	-0.4953650642263606	[137]	[51,52]	-7	hSpCas9	negative selection	909276
136172442	136172465	5	-	26627737	GBM cells	viability after 5 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	-0.2904001116648173	[308]	[122,147]	-4	hSpCas9	negative selection	909277
136174569	136174592	5	-	26627737	GBM cells	viability after 5 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	-0.025797997810077078	[55]	[14,43]	0	hSpCas9	negative selection	909278
136154023	136154046	5	+	26627737	GBM cells	viability after 13 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	0.1408963039407658	[85]	[51,50]	1	hSpCas9	negative selection	991588
136160908	136160931	5	-	26627737	GBM cells	viability after 13 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-1.3272828195681101	[58]	[9,14]	-8	hSpCas9	negative selection	991589
136163283	136163306	5	-	26627737	GBM cells	viability after 13 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	-0.2471829628292088	[215]	[138,65]	-3	hSpCas9	negative selection	991590
136163298	136163321	5	-	26627737	GBM cells	viability after 13 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	-0.0035554158332629093	[137]	[77,71]	0	hSpCas9	negative selection	991591
136172442	136172465	5	-	26627737	GBM cells	viability after 13 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	-0.3662578745738872	[308]	[123,134]	-4	hSpCas9	negative selection	991592
136174569	136174592	5	-	26627737	GBM cells	viability after 13 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	0.7293842300488107	[55]	[40,57]	8	hSpCas9	negative selection	991593
136154023	136154046	5	+	26627737	GBM cells	viability after 21 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	0.6968250688097237	[85]	[81,69]	7	hSpCas9	negative selection	1073903
136160908	136160931	5	-	26627737	GBM cells	viability after 21 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.574654607472604	[58]	[20,21]	-5	hSpCas9	negative selection	1073904
136163283	136163306	5	-	26627737	GBM cells	viability after 21 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	-0.23159973273864023	[215]	[112,87]	-2	hSpCas9	negative selection	1073905
136163298	136163321	5	-	26627737	GBM cells	viability after 21 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	-0.07786687498832567	[137]	[81,60]	0	hSpCas9	negative selection	1073906
136172442	136172465	5	-	26627737	GBM cells	viability after 21 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	-0.021898966568870137	[308]	[168,161]	0	hSpCas9	negative selection	1073907
136174569	136174592	5	-	26627737	GBM cells	viability after 21 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	0.055238218422323904	[55]	[28,33]	0	hSpCas9	negative selection	1073908
136154023	136154046	5	+	26627737	RPE1	viability after 9 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	0.28633589429264755	[537]	[128,303]	2	hSpCas9	negative selection	1156218
136160908	136160931	5	-	26627737	RPE1	viability after 9 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-1.5958796529991441	[115]	[18,2]	-8	hSpCas9	negative selection	1156219
136163283	136163306	5	-	26627737	RPE1	viability after 9 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	0.9047028675124956	[704]	[393,437]	6	hSpCas9	negative selection	1156220
136163298	136163321	5	-	26627737	RPE1	viability after 9 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	0.8197541485437911	[681]	[220,577]	5	hSpCas9	negative selection	1156221
136172442	136172465	5	-	26627737	RPE1	viability after 9 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	0.27035782424298926	[670]	[217,298]	2	hSpCas9	negative selection	1156222
136174569	136174592	5	-	26627737	RPE1	viability after 9 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	-0.06108214832990999	[123]	[17,61]	0	hSpCas9	negative selection	1156223
136154023	136154046	5	+	26627737	RPE1	viability after 12 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	0.30592953609658735	[537]	[150,207]	2	hSpCas9	negative selection	1238533
136160908	136160931	5	-	26627737	RPE1	viability after 12 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-1.906277257491117	[115]	[1,14]	-8	hSpCas9	negative selection	1238534
136163283	136163306	5	-	26627737	RPE1	viability after 12 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	0.7369771300629098	[704]	[287,344]	5	hSpCas9	negative selection	1238535
136163298	136163321	5	-	26627737	RPE1	viability after 12 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	0.6095566012181652	[681]	[145,420]	4	hSpCas9	negative selection	1238536
136172442	136172465	5	-	26627737	RPE1	viability after 12 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	0.19883190000416562	[670]	[254,155]	1	hSpCas9	negative selection	1238537
136174569	136174592	5	-	26627737	RPE1	viability after 12 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	-0.11456538111449621	[123]	[22,38]	-1	hSpCas9	negative selection	1238538
136154023	136154046	5	+	26627737	RPE1	viability after 15 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	0.1472399286282457	[537]	[109,224]	1	hSpCas9	negative selection	1320848
136160908	136160931	5	-	26627737	RPE1	viability after 15 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-2.2438761131473215	[115]	[10,2]	-8	hSpCas9	negative selection	1320849
136163283	136163306	5	-	26627737	RPE1	viability after 15 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	0.5175134646071582	[704]	[145,419]	3	hSpCas9	negative selection	1320850
136163298	136163321	5	-	26627737	RPE1	viability after 15 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	0.8246557991261712	[681]	[302,378]	5	hSpCas9	negative selection	1320851
136172442	136172465	5	-	26627737	RPE1	viability after 15 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	0.39788635038180287	[670]	[244,254]	2	hSpCas9	negative selection	1320852
136174569	136174592	5	-	26627737	RPE1	viability after 15 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	-0.033510290021992795	[123]	[18,48]	0	hSpCas9	negative selection	1320853
136154023	136154046	5	+	26627737	RPE1	viability after 18 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	0.10859605800982053	[537]	[113,201]	0	hSpCas9	negative selection	1403163
136160908	136160931	5	-	26627737	RPE1	viability after 18 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-2.2715594088481166	[115]	[5,6]	-8	hSpCas9	negative selection	1403164
136163283	136163306	5	-	26627737	RPE1	viability after 18 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	1.2516767968985447	[704]	[220,700]	7	hSpCas9	negative selection	1403165
136163298	136163321	5	-	26627737	RPE1	viability after 18 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	0.9651178065365246	[681]	[309,411]	6	hSpCas9	negative selection	1403166
136172442	136172465	5	-	26627737	RPE1	viability after 18 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	0.4875377908003755	[670]	[235,272]	3	hSpCas9	negative selection	1403167
136174569	136174592	5	-	26627737	RPE1	viability after 18 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	0.22034811750706407	[123]	[23,54]	1	hSpCas9	negative selection	1403168
136154023	136154046	5	+	26627737	HeLa	viability after 8 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	1.1806667098548909	[119]	[133,201,28]	8	hSpCas9	negative selection	1485478
136160908	136160931	5	-	26627737	HeLa	viability after 8 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-2.2881703405245886	[75]	[7,11,0]	-9	hSpCas9	negative selection	1485479
136163283	136163306	5	-	26627737	HeLa	viability after 8 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	-0.5654144729486674	[466]	[80,246,75]	-5	hSpCas9	negative selection	1485480
136163298	136163321	5	-	26627737	HeLa	viability after 8 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	0.08391047274588082	[101]	[13,74,44]	0	hSpCas9	negative selection	1485481
136172442	136172465	5	-	26627737	HeLa	viability after 8 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	-0.28330250020463643	[357]	[172,108,112]	-3	hSpCas9	negative selection	1485482
136174569	136174592	5	-	26627737	HeLa	viability after 8 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	-0.33866430182496954	[33]	[34,4,0]	-3	hSpCas9	negative selection	1485483
136154023	136154046	5	+	26627737	HeLa	viability after 12 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	0.0950521819008947	[119]	[27,82,43]	0	hSpCas9	negative selection	1567793
136160908	136160931	5	-	26627737	HeLa	viability after 12 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-1.2973115715477341	[75]	[26,0,11]	-8	hSpCas9	negative selection	1567794
136163283	136163306	5	-	26627737	HeLa	viability after 12 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	-0.4591740225717662	[466]	[134,196,82]	-4	hSpCas9	negative selection	1567795
136163298	136163321	5	-	26627737	HeLa	viability after 12 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	-0.601499033644447	[101]	[10,16,55]	-5	hSpCas9	negative selection	1567796
136172442	136172465	5	-	26627737	HeLa	viability after 12 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	0.06632102958444323	[357]	[211,167,84]	0	hSpCas9	negative selection	1567797
136174569	136174592	5	-	26627737	HeLa	viability after 12 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	0.6980068649215911	[33]	[13,23,29]	5	hSpCas9	negative selection	1567798
136154023	136154046	5	+	26627737	HeLa	viability after 15 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	0.758610528419412	[119]	[51,129,64]	6	hSpCas9	negative selection	1650108
136160908	136160931	5	-	26627737	HeLa	viability after 15 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.974915272211752	[75]	[40,0,3]	-7	hSpCas9	negative selection	1650109
136163283	136163306	5	-	26627737	HeLa	viability after 15 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	-0.29001052995802423	[466]	[142,175,146]	-2	hSpCas9	negative selection	1650110
136163298	136163321	5	-	26627737	HeLa	viability after 15 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	0.5018536057857681	[101]	[59,25,92]	4	hSpCas9	negative selection	1650111
136172442	136172465	5	-	26627737	HeLa	viability after 15 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	-0.0950457109604626	[357]	[161,134,109]	-1	hSpCas9	negative selection	1650112
136174569	136174592	5	-	26627737	HeLa	viability after 15 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	-0.3478630066480721	[33]	[0,29,0]	-3	hSpCas9	negative selection	1650113
136154023	136154046	5	+	26627737	HeLa	viability after 18 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	0.7764030923452245	[119]	[38,104,64]	6	hSpCas9	negative selection	1732423
136160908	136160931	5	-	26627737	HeLa	viability after 18 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-1.091249160756743	[75]	[24,0,3]	-7	hSpCas9	negative selection	1732424
136163283	136163306	5	-	26627737	HeLa	viability after 18 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	-0.2839863300927682	[466]	[104,135,146]	-2	hSpCas9	negative selection	1732425
136163298	136163321	5	-	26627737	HeLa	viability after 18 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	0.48560434092477767	[101]	[40,18,92]	4	hSpCas9	negative selection	1732426
136172442	136172465	5	-	26627737	HeLa	viability after 18 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	-0.04128847220792778	[357]	[112,118,109]	0	hSpCas9	negative selection	1732427
136174569	136174592	5	-	26627737	HeLa	viability after 18 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	-0.21402893607035445	[33]	[0,26,0]	-2	hSpCas9	negative selection	1732428
136154023	136154046	5	+	26627737	HCT116	viability after 6 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	1.1363823357996998	[147]	[103,21]	6	hSpCas9	negative selection	1814738
136160908	136160931	5	-	26627737	HCT116	viability after 6 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.4607918081183797	[71]	[12,16]	2	hSpCas9	negative selection	1814739
136163283	136163306	5	-	26627737	HCT116	viability after 6 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	-0.31891957305271157	[423]	[104,24]	-2	hSpCas9	negative selection	1814740
136163298	136163321	5	-	26627737	HCT116	viability after 6 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	0.6127369312390316	[317]	[205,4]	3	hSpCas9	negative selection	1814741
136172442	136172465	5	-	26627737	HCT116	viability after 6 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	-2.0281228625458105	[542]	[47,5]	-8	hSpCas9	negative selection	1814742
136174569	136174592	5	-	26627737	HCT116	viability after 6 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	-0.567211160055701	[128]	[23,7]	-3	hSpCas9	negative selection	1814743
136154023	136154046	5	+	26627737	HCT116	viability after 8 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	1.09541726614443	[71]	[87,132,33]	8	hSpCas9	negative selection	1897053
136160908	136160931	5	-	26627737	HCT116	viability after 8 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	2.3762488643979416	[5]	[0,15,33]	9	hSpCas9	negative selection	1897054
136163283	136163306	5	-	26627737	HCT116	viability after 8 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	-0.582857748499919	[502]	[151,171,229]	-6	hSpCas9	negative selection	1897055
136163298	136163321	5	-	26627737	HCT116	viability after 8 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	0.5223844866441757	[116]	[90,112,73]	5	hSpCas9	negative selection	1897056
136172442	136172465	5	-	26627737	HCT116	viability after 8 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	0.7168260076368242	[219]	[211,272,113]	6	hSpCas9	negative selection	1897057
136174569	136174592	5	-	26627737	HCT116	viability after 8 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	-0.615458626731441	[77]	[20,31,30]	-6	hSpCas9	negative selection	1897058
136154023	136154046	5	+	26627737	HCT116	viability after 9 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	1.5341157765173703	[147]	[133,98]	8	hSpCas9	negative selection	1979368
136160908	136160931	5	-	26627737	HCT116	viability after 9 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-2.3416746333725533	[71]	[0,5]	-9	hSpCas9	negative selection	1979369
136163283	136163306	5	-	26627737	HCT116	viability after 9 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	0.5937052416217631	[423]	[238,116]	4	hSpCas9	negative selection	1979370
136163298	136163321	5	-	26627737	HCT116	viability after 9 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	-0.4070810442523146	[317]	[139,3]	-3	hSpCas9	negative selection	1979371
136172442	136172465	5	-	26627737	HCT116	viability after 9 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	0.4663752239474229	[542]	[325,100]	3	hSpCas9	negative selection	1979372
136174569	136174592	5	-	26627737	HCT116	viability after 9 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	-1.6936389902423592	[128]	[13,7]	-8	hSpCas9	negative selection	1979373
136154023	136154046	5	+	26627737	HCT116	viability after 12 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	1.105129890491014	[71]	[38,84,123]	8	hSpCas9	negative selection	2061683
136160908	136160931	5	-	26627737	HCT116	viability after 12 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	2.4489471973390033	[5]	[3,24,23]	9	hSpCas9	negative selection	2061684
136163283	136163306	5	-	26627737	HCT116	viability after 12 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	-1.1328272655944425	[502]	[156,143,57]	-8	hSpCas9	negative selection	2061685
136163298	136163321	5	-	26627737	HCT116	viability after 12 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	0.05237832167421108	[116]	[42,141,9]	0	hSpCas9	negative selection	2061686
136172442	136172465	5	-	26627737	HCT116	viability after 12 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	0.5749963547428796	[219]	[147,220,150]	5	hSpCas9	negative selection	2061687
136174569	136174592	5	-	26627737	HCT116	viability after 12 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	0.3607583896060651	[77]	[4,89,67]	3	hSpCas9	negative selection	2061688
136154023	136154046	5	+	26627737	HCT116	viability after 15 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	0.8043522258297082	[71]	[68,54,91]	7	hSpCas9	negative selection	2143998
136160908	136160931	5	-	26627737	HCT116	viability after 15 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	2.6602236893190394	[5]	[34,13,17]	9	hSpCas9	negative selection	2143999
136163283	136163306	5	-	26627737	HCT116	viability after 15 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	-0.5212073690755492	[502]	[328,139,150]	-5	hSpCas9	negative selection	2144000
136163298	136163321	5	-	26627737	HCT116	viability after 15 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	0.649035351612202	[116]	[43,106,156]	6	hSpCas9	negative selection	2144001
136172442	136172465	5	-	26627737	HCT116	viability after 15 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	1.1357993149777927	[219]	[344,293,202]	8	hSpCas9	negative selection	2144002
136174569	136174592	5	-	26627737	HCT116	viability after 15 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	-0.48119115545809543	[77]	[5,46,39]	-5	hSpCas9	negative selection	2144003
136154023	136154046	5	+	26627737	HCT116	viability after 18 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	1.8943300933939633	[71]	[205,73,110]	9	hSpCas9	negative selection	2226313
136160908	136160931	5	-	26627737	HCT116	viability after 18 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	2.500057917559545	[5]	[9,20,17]	9	hSpCas9	negative selection	2226314
136163283	136163306	5	-	26627737	HCT116	viability after 18 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	-0.7968435973890576	[502]	[181,181,48]	-6	hSpCas9	negative selection	2226315
136163298	136163321	5	-	26627737	HCT116	viability after 18 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	1.0371479401336794	[116]	[15,201,124]	7	hSpCas9	negative selection	2226316
136172442	136172465	5	-	26627737	HCT116	viability after 18 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	0.9735087002936176	[219]	[230,212,180]	7	hSpCas9	negative selection	2226317
136174569	136174592	5	-	26627737	HCT116	viability after 18 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	0.34257569570311963	[77]	[0,87,51]	3	hSpCas9	negative selection	2226318
136153751	136153774	5	+	24336569	HL60	viability	TTTGTGTCAAATGACGTCAATGG	SMAD5	ENSG00000113658	0.3420904816798044	[569]	[1528]	3	hSpCas9	negative selection	2295673
136153796	136153819	5	+	24336569	HL60	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	1.1098251032991402	[498]	[2278]	8	hSpCas9	negative selection	2295674
136153801	136153824	5	+	24336569	HL60	viability	CAGTAAAGCGATTGTTGGGCTGG	SMAD5	ENSG00000113658	-0.8620617218982598	[206]	[240]	-7	hSpCas9	negative selection	2295675
136153809	136153832	5	+	24336569	HL60	viability	CGATTGTTGGGCTGGAAACAAGG	SMAD5	ENSG00000113658	0.32938316903891035	[430]	[1145]	3	hSpCas9	negative selection	2295676
136153817	136153840	5	+	24336569	HL60	viability	GGGCTGGAAACAAGGTGATGAGG	SMAD5	ENSG00000113658	-0.00991083960386241	[943]	[1983]	0	hSpCas9	negative selection	2295677
136153828	136153851	5	+	24336569	HL60	viability	AAGGTGATGAGGAGGAGAAATGG	SMAD5	ENSG00000113658	-0.15051285264843195	[994]	[1896]	-1	hSpCas9	negative selection	2295678
136153895	136153918	5	+	24336569	HL60	viability	AAAGGGTGCCATGGAGGAACTGG	SMAD5	ENSG00000113658	-1.2338090244370878	[468]	[421]	-8	hSpCas9	negative selection	2295679
136153903	136153926	5	-	24336569	HL60	viability	GGCTTTCTCCAGTTCCTCCATGG	SMAD5	ENSG00000113658	0.9032691427177932	[94]	[375]	7	hSpCas9	negative selection	2295680
136153917	136153940	5	+	24336569	HL60	viability	GAGAAAGCCTTGAGCAGTCCAGG	SMAD5	ENSG00000113658	0.2560562933992359	[680]	[1720]	2	hSpCas9	negative selection	2295681
136153924	136153947	5	-	24336569	HL60	viability	CGGCTGTCCTGGACTGCTCAAGG	SMAD5	ENSG00000113658	0.15806636829928267	[1051]	[2483]	1	hSpCas9	negative selection	2295682
136153751	136153774	5	+	24336569	KBM7	viability	TTTGTGTCAAATGACGTCAATGG	SMAD5	ENSG00000113658	0.6129623453861682	[384]	[1605]	5	hSpCas9	negative selection	2362850
136153796	136153819	5	+	24336569	KBM7	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.48269723980380097	[498]	[973]	-4	hSpCas9	negative selection	2362851
136153801	136153824	5	+	24336569	KBM7	viability	CAGTAAAGCGATTGTTGGGCTGG	SMAD5	ENSG00000113658	1.1433448624109905	[160]	[969]	8	hSpCas9	negative selection	2362852
136153809	136153832	5	+	24336569	KBM7	viability	CGATTGTTGGGCTGGAAACAAGG	SMAD5	ENSG00000113658	0.4900287644387627	[442]	[1696]	4	hSpCas9	negative selection	2362853
136153817	136153840	5	+	24336569	KBM7	viability	GGGCTGGAAACAAGGTGATGAGG	SMAD5	ENSG00000113658	0.6454456195841896	[532]	[2273]	6	hSpCas9	negative selection	2362854
136153828	136153851	5	+	24336569	KBM7	viability	AAGGTGATGAGGAGGAGAAATGG	SMAD5	ENSG00000113658	-0.4324948690098277	[998]	[2018]	-4	hSpCas9	negative selection	2362855
136153895	136153918	5	+	24336569	KBM7	viability	AAAGGGTGCCATGGAGGAACTGG	SMAD5	ENSG00000113658	0.7401602229623874	[312]	[1425]	6	hSpCas9	negative selection	2362856
136153903	136153926	5	-	24336569	KBM7	viability	GGCTTTCTCCAGTTCCTCCATGG	SMAD5	ENSG00000113658	-0.7261544532784543	[167]	[276]	-5	hSpCas9	negative selection	2362857
136153917	136153940	5	+	24336569	KBM7	viability	GAGAAAGCCTTGAGCAGTCCAGG	SMAD5	ENSG00000113658	-0.1809009622269826	[691]	[1664]	-1	hSpCas9	negative selection	2362858
136153924	136153947	5	-	24336569	KBM7	viability	CGGCTGTCCTGGACTGCTCAAGG	SMAD5	ENSG00000113658	0.3398916200269205	[740]	[2557]	3	hSpCas9	negative selection	2362859
136153809	136153832	5	+	27260157	DLD1	viability	CGATTGTTGGGCTGGAAACAAGG	SMAD5	ENSG00000113658	-0.364024793688933	[]	[]	-3	hSpCas9	negative selection	2574568
136154060	136154083	5	+	27260157	DLD1	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.0557110861740856	[]	[]	0	hSpCas9	negative selection	2580508
136153965	136153988	5	-	27260157	DLD1	viability	AGGCGTCCATCTAAAGATCTGGG	SMAD5	ENSG00000113658	0.761776910991977	[]	[]	8	hSpCas9	negative selection	2581638
136153828	136153851	5	+	27260157	DLD1	viability	AAGGTGATGAGGAGGAGAAATGG	SMAD5	ENSG00000113658	-0.956896286094117	[]	[]	-7	hSpCas9	negative selection	2583504
136154023	136154046	5	+	27260157	DLD1	viability	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	-2.29358734751882	[]	[]	-9	hSpCas9	negative selection	2583988
136153917	136153940	5	+	27260157	DLD1	viability	GAGAAAGCCTTGAGCAGTCCAGG	SMAD5	ENSG00000113658	0.12452935339932	[]	[]	3	hSpCas9	negative selection	2587015
136154138	136154161	5	-	27260157	DLD1	viability	GACTCTCCACTCTCTTATAGTGG	SMAD5	ENSG00000113658	0.897207166126601	[]	[]	9	hSpCas9	negative selection	2607474
136154132	136154155	5	+	27260157	DLD1	viability	CCCATACCACTATAAGAGAGTGG	SMAD5	ENSG00000113658	-0.0260170400997152	[]	[]	0	hSpCas9	negative selection	2612998
136153820	136153843	5	+	27260157	DLD1	viability	CTGGAAACAAGGTGATGAGGAGG	SMAD5	ENSG00000113658	0.312816228699508	[]	[]	4	hSpCas9	negative selection	2613013
136153970	136153993	5	+	27260157	DLD1	viability	ATCTTTAGATGGACGCCTGCAGG	SMAD5	ENSG00000113658	0.676036347743663	[]	[]	8	hSpCas9	negative selection	2615119
136153895	136153918	5	+	27260157	DLD1	viability	AAAGGGTGCCATGGAGGAACTGG	SMAD5	ENSG00000113658	-0.828031737296232	[]	[]	-6	hSpCas9	negative selection	2615569
136153924	136153947	5	-	27260157	DLD1	viability	CGGCTGTCCTGGACTGCTCAAGG	SMAD5	ENSG00000113658	0.982690372642512	[]	[]	9	hSpCas9	negative selection	2615734
136153801	136153824	5	+	27260157	DLD1	viability	CAGTAAAGCGATTGTTGGGCTGG	SMAD5	ENSG00000113658	-0.0678335796321208	[]	[]	0	hSpCas9	negative selection	2619727
136153797	136153820	5	-	27260157	DLD1	viability	CCCAACAATCGCTTTACTGCTGG	SMAD5	ENSG00000113658	0.74842079448631	[]	[]	8	hSpCas9	negative selection	2621996
136153935	136153958	5	-	27260157	DLD1	viability	ACACATTTACTCGGCTGTCCTGG	SMAD5	ENSG00000113658	0.554032888685228	[]	[]	8	hSpCas9	negative selection	2641773
136153796	136153819	5	+	27260157	DLD1	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.125426005361911	[]	[]	-1	hSpCas9	negative selection	2642225
136153817	136153840	5	+	27260157	DLD1	viability	GGGCTGGAAACAAGGTGATGAGG	SMAD5	ENSG00000113658	-0.670943231173899	[]	[]	-5	hSpCas9	negative selection	2644441
136153986	136154009	5	+	27260157	DLD1	viability	CTGCAGGTTTCTCACAGAAAAGG	SMAD5	ENSG00000113658	0.29441473073993	[]	[]	4	hSpCas9	negative selection	2644977
136153903	136153926	5	-	27260157	DLD1	viability	GGCTTTCTCCAGTTCCTCCATGG	SMAD5	ENSG00000113658	0.12309411963074	[]	[]	3	hSpCas9	negative selection	2647700
136153751	136153774	5	+	27260157	DLD1	viability	TTTGTGTCAAATGACGTCAATGG	SMAD5	ENSG00000113658	-0.758286095122231	[]	[]	-5	hSpCas9	negative selection	2648943
136153809	136153832	5	+	27260157	HT1080	viability	CGATTGTTGGGCTGGAAACAAGG	SMAD5	ENSG00000113658	-0.269693756148389	[]	[]	-4	hSpCas9	negative selection	2650698
136154060	136154083	5	+	27260157	HT1080	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.518440076586515	[]	[]	-7	hSpCas9	negative selection	2656638
136153965	136153988	5	-	27260157	HT1080	viability	AGGCGTCCATCTAAAGATCTGGG	SMAD5	ENSG00000113658	-0.0810627914889546	[]	[]	0	hSpCas9	negative selection	2657768
136153828	136153851	5	+	27260157	HT1080	viability	AAGGTGATGAGGAGGAGAAATGG	SMAD5	ENSG00000113658	-1.29762801785536	[]	[]	-9	hSpCas9	negative selection	2659634
136154023	136154046	5	+	27260157	HT1080	viability	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	-1.49743545991922	[]	[]	-9	hSpCas9	negative selection	2660118
136153917	136153940	5	+	27260157	HT1080	viability	GAGAAAGCCTTGAGCAGTCCAGG	SMAD5	ENSG00000113658	1.34261073169534	[]	[]	9	hSpCas9	negative selection	2663145
136154138	136154161	5	-	27260157	HT1080	viability	GACTCTCCACTCTCTTATAGTGG	SMAD5	ENSG00000113658	0.46067791845536	[]	[]	4	hSpCas9	negative selection	2683604
136154132	136154155	5	+	27260157	HT1080	viability	CCCATACCACTATAAGAGAGTGG	SMAD5	ENSG00000113658	-0.108563685000713	[]	[]	0	hSpCas9	negative selection	2689128
136153820	136153843	5	+	27260157	HT1080	viability	CTGGAAACAAGGTGATGAGGAGG	SMAD5	ENSG00000113658	1.05437965848558	[]	[]	8	hSpCas9	negative selection	2689143
136153970	136153993	5	+	27260157	HT1080	viability	ATCTTTAGATGGACGCCTGCAGG	SMAD5	ENSG00000113658	1.06109411990628	[]	[]	8	hSpCas9	negative selection	2691249
136153895	136153918	5	+	27260157	HT1080	viability	AAAGGGTGCCATGGAGGAACTGG	SMAD5	ENSG00000113658	1.07691448292422	[]	[]	8	hSpCas9	negative selection	2691699
136153924	136153947	5	-	27260157	HT1080	viability	CGGCTGTCCTGGACTGCTCAAGG	SMAD5	ENSG00000113658	0.371954702467826	[]	[]	3	hSpCas9	negative selection	2691864
136153801	136153824	5	+	27260157	HT1080	viability	CAGTAAAGCGATTGTTGGGCTGG	SMAD5	ENSG00000113658	-0.355541320562983	[]	[]	-7	hSpCas9	negative selection	2695857
136153797	136153820	5	-	27260157	HT1080	viability	CCCAACAATCGCTTTACTGCTGG	SMAD5	ENSG00000113658	1.02018265294152	[]	[]	8	hSpCas9	negative selection	2698126
136153935	136153958	5	-	27260157	HT1080	viability	ACACATTTACTCGGCTGTCCTGG	SMAD5	ENSG00000113658	0.623849395801148	[]	[]	5	hSpCas9	negative selection	2717903
136153796	136153819	5	+	27260157	HT1080	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	0.0688091550457972	[]	[]	0	hSpCas9	negative selection	2718355
136153817	136153840	5	+	27260157	HT1080	viability	GGGCTGGAAACAAGGTGATGAGG	SMAD5	ENSG00000113658	0.368046401933171	[]	[]	3	hSpCas9	negative selection	2720571
136153986	136154009	5	+	27260157	HT1080	viability	CTGCAGGTTTCTCACAGAAAAGG	SMAD5	ENSG00000113658	0.688986805963848	[]	[]	6	hSpCas9	negative selection	2721107
136153903	136153926	5	-	27260157	HT1080	viability	GGCTTTCTCCAGTTCCTCCATGG	SMAD5	ENSG00000113658	-0.199496729504429	[]	[]	0	hSpCas9	negative selection	2723830
136153751	136153774	5	+	27260157	HT1080	viability	TTTGTGTCAAATGACGTCAATGG	SMAD5	ENSG00000113658	-0.280639401852107	[]	[]	-4	hSpCas9	negative selection	2725073
136153809	136153832	5	+	27260157	MKN45	viability	CGATTGTTGGGCTGGAAACAAGG	SMAD5	ENSG00000113658	-0.113195995413124	[]	[]	0	hSpCas9	negative selection	2726828
136154060	136154083	5	+	27260157	MKN45	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	0.760783590221452	[]	[]	7	hSpCas9	negative selection	2732768
136153965	136153988	5	-	27260157	MKN45	viability	AGGCGTCCATCTAAAGATCTGGG	SMAD5	ENSG00000113658	0.518136082723491	[]	[]	6	hSpCas9	negative selection	2733898
136153828	136153851	5	+	27260157	MKN45	viability	AAGGTGATGAGGAGGAGAAATGG	SMAD5	ENSG00000113658	-0.300073791361454	[]	[]	-1	hSpCas9	negative selection	2735764
136154023	136154046	5	+	27260157	MKN45	viability	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	-2.46352699957497	[]	[]	-9	hSpCas9	negative selection	2736248
136153917	136153940	5	+	27260157	MKN45	viability	GAGAAAGCCTTGAGCAGTCCAGG	SMAD5	ENSG00000113658	0.997288596674422	[]	[]	8	hSpCas9	negative selection	2739275
136154138	136154161	5	-	27260157	MKN45	viability	GACTCTCCACTCTCTTATAGTGG	SMAD5	ENSG00000113658	-0.00236470417822367	[]	[]	0	hSpCas9	negative selection	2759734
136154132	136154155	5	+	27260157	MKN45	viability	CCCATACCACTATAAGAGAGTGG	SMAD5	ENSG00000113658	1.22099409372665	[]	[]	9	hSpCas9	negative selection	2765258
136153820	136153843	5	+	27260157	MKN45	viability	CTGGAAACAAGGTGATGAGGAGG	SMAD5	ENSG00000113658	-0.0316794600134616	[]	[]	0	hSpCas9	negative selection	2765273
136153970	136153993	5	+	27260157	MKN45	viability	ATCTTTAGATGGACGCCTGCAGG	SMAD5	ENSG00000113658	0.950525545626562	[]	[]	8	hSpCas9	negative selection	2767379
136153895	136153918	5	+	27260157	MKN45	viability	AAAGGGTGCCATGGAGGAACTGG	SMAD5	ENSG00000113658	0.0984931259910058	[]	[]	0	hSpCas9	negative selection	2767829
136153924	136153947	5	-	27260157	MKN45	viability	CGGCTGTCCTGGACTGCTCAAGG	SMAD5	ENSG00000113658	1.23171318281026	[]	[]	9	hSpCas9	negative selection	2767994
136153801	136153824	5	+	27260157	MKN45	viability	CAGTAAAGCGATTGTTGGGCTGG	SMAD5	ENSG00000113658	0.547715567228914	[]	[]	7	hSpCas9	negative selection	2771987
136153797	136153820	5	-	27260157	MKN45	viability	CCCAACAATCGCTTTACTGCTGG	SMAD5	ENSG00000113658	0.184509507204342	[]	[]	5	hSpCas9	negative selection	2774256
136153935	136153958	5	-	27260157	MKN45	viability	ACACATTTACTCGGCTGTCCTGG	SMAD5	ENSG00000113658	0.829787475371282	[]	[]	8	hSpCas9	negative selection	2794033
136153796	136153819	5	+	27260157	MKN45	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.635672841436854	[]	[]	-6	hSpCas9	negative selection	2794485
136153817	136153840	5	+	27260157	MKN45	viability	GGGCTGGAAACAAGGTGATGAGG	SMAD5	ENSG00000113658	-1.06987776488295	[]	[]	-8	hSpCas9	negative selection	2796701
136153986	136154009	5	+	27260157	MKN45	viability	CTGCAGGTTTCTCACAGAAAAGG	SMAD5	ENSG00000113658	0.393806575106024	[]	[]	6	hSpCas9	negative selection	2797237
136153903	136153926	5	-	27260157	MKN45	viability	GGCTTTCTCCAGTTCCTCCATGG	SMAD5	ENSG00000113658	0.121621825390362	[]	[]	4	hSpCas9	negative selection	2799960
136153751	136153774	5	+	27260157	MKN45	viability	TTTGTGTCAAATGACGTCAATGG	SMAD5	ENSG00000113658	-0.452350108399897	[]	[]	-6	hSpCas9	negative selection	2801203
136153809	136153832	5	+	27260157	RKO	viability	CGATTGTTGGGCTGGAAACAAGG	SMAD5	ENSG00000113658	-0.33682348210533	[]	[]	-6	hSpCas9	negative selection	2802958
136154060	136154083	5	+	27260157	RKO	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	0.606030832879236	[]	[]	3	hSpCas9	negative selection	2808898
136153965	136153988	5	-	27260157	RKO	viability	AGGCGTCCATCTAAAGATCTGGG	SMAD5	ENSG00000113658	-0.373948889631903	[]	[]	-6	hSpCas9	negative selection	2810028
136153828	136153851	5	+	27260157	RKO	viability	AAGGTGATGAGGAGGAGAAATGG	SMAD5	ENSG00000113658	-2.75268120916101	[]	[]	-9	hSpCas9	negative selection	2811894
136154023	136154046	5	+	27260157	RKO	viability	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	-0.926014893177376	[]	[]	-8	hSpCas9	negative selection	2812378
136153917	136153940	5	+	27260157	RKO	viability	GAGAAAGCCTTGAGCAGTCCAGG	SMAD5	ENSG00000113658	0.599228932101675	[]	[]	3	hSpCas9	negative selection	2815405
136154138	136154161	5	-	27260157	RKO	viability	GACTCTCCACTCTCTTATAGTGG	SMAD5	ENSG00000113658	-0.16887153350889	[]	[]	-1	hSpCas9	negative selection	2835864
136154132	136154155	5	+	27260157	RKO	viability	CCCATACCACTATAAGAGAGTGG	SMAD5	ENSG00000113658	0.600758812706478	[]	[]	3	hSpCas9	negative selection	2841388
136153820	136153843	5	+	27260157	RKO	viability	CTGGAAACAAGGTGATGAGGAGG	SMAD5	ENSG00000113658	0.450264301367924	[]	[]	2	hSpCas9	negative selection	2841403
136153970	136153993	5	+	27260157	RKO	viability	ATCTTTAGATGGACGCCTGCAGG	SMAD5	ENSG00000113658	1.29880168413354	[]	[]	9	hSpCas9	negative selection	2843509
136153895	136153918	5	+	27260157	RKO	viability	AAAGGGTGCCATGGAGGAACTGG	SMAD5	ENSG00000113658	-0.453309092708085	[]	[]	-6	hSpCas9	negative selection	2843959
136153924	136153947	5	-	27260157	RKO	viability	CGGCTGTCCTGGACTGCTCAAGG	SMAD5	ENSG00000113658	1.68727555809854	[]	[]	9	hSpCas9	negative selection	2844124
136153801	136153824	5	+	27260157	RKO	viability	CAGTAAAGCGATTGTTGGGCTGG	SMAD5	ENSG00000113658	-0.688931182962399	[]	[]	-7	hSpCas9	negative selection	2848117
136153797	136153820	5	-	27260157	RKO	viability	CCCAACAATCGCTTTACTGCTGG	SMAD5	ENSG00000113658	1.20916059405545	[]	[]	9	hSpCas9	negative selection	2850386
136153935	136153958	5	-	27260157	RKO	viability	ACACATTTACTCGGCTGTCCTGG	SMAD5	ENSG00000113658	0.214320830843272	[]	[]	1	hSpCas9	negative selection	2870163
136153796	136153819	5	+	27260157	RKO	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.365529764374735	[]	[]	-6	hSpCas9	negative selection	2870615
136153817	136153840	5	+	27260157	RKO	viability	GGGCTGGAAACAAGGTGATGAGG	SMAD5	ENSG00000113658	-0.384952917431144	[]	[]	-6	hSpCas9	negative selection	2872831
136153986	136154009	5	+	27260157	RKO	viability	CTGCAGGTTTCTCACAGAAAAGG	SMAD5	ENSG00000113658	0.324495415140198	[]	[]	1	hSpCas9	negative selection	2873367
136153903	136153926	5	-	27260157	RKO	viability	GGCTTTCTCCAGTTCCTCCATGG	SMAD5	ENSG00000113658	-0.631633192336509	[]	[]	-7	hSpCas9	negative selection	2876090
136153751	136153774	5	+	27260157	RKO	viability	TTTGTGTCAAATGACGTCAATGG	SMAD5	ENSG00000113658	-0.162803338456863	[]	[]	-1	hSpCas9	negative selection	2877333
136153809	136153832	5	+	27260157	SF268	viability	CGATTGTTGGGCTGGAAACAAGG	SMAD5	ENSG00000113658	-0.671111174583825	[]	[]	-5	hSpCas9	negative selection	2879088
136154060	136154083	5	+	27260157	SF268	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	0.621142821455832	[]	[]	8	hSpCas9	negative selection	2885028
136153965	136153988	5	-	27260157	SF268	viability	AGGCGTCCATCTAAAGATCTGGG	SMAD5	ENSG00000113658	0.67622839267522	[]	[]	8	hSpCas9	negative selection	2886158
136153828	136153851	5	+	27260157	SF268	viability	AAGGTGATGAGGAGGAGAAATGG	SMAD5	ENSG00000113658	-1.31613342250507	[]	[]	-7	hSpCas9	negative selection	2888024
136154023	136154046	5	+	27260157	SF268	viability	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	-1.11659151097821	[]	[]	-7	hSpCas9	negative selection	2888508
136153917	136153940	5	+	27260157	SF268	viability	GAGAAAGCCTTGAGCAGTCCAGG	SMAD5	ENSG00000113658	1.15258935774726	[]	[]	9	hSpCas9	negative selection	2891535
136154138	136154161	5	-	27260157	SF268	viability	GACTCTCCACTCTCTTATAGTGG	SMAD5	ENSG00000113658	0.523070461991889	[]	[]	8	hSpCas9	negative selection	2911994
136154132	136154155	5	+	27260157	SF268	viability	CCCATACCACTATAAGAGAGTGG	SMAD5	ENSG00000113658	0.991008531090416	[]	[]	9	hSpCas9	negative selection	2917518
136153820	136153843	5	+	27260157	SF268	viability	CTGGAAACAAGGTGATGAGGAGG	SMAD5	ENSG00000113658	1.52448436389766	[]	[]	9	hSpCas9	negative selection	2917533
136153970	136153993	5	+	27260157	SF268	viability	ATCTTTAGATGGACGCCTGCAGG	SMAD5	ENSG00000113658	1.4986120276021	[]	[]	9	hSpCas9	negative selection	2919639
136153895	136153918	5	+	27260157	SF268	viability	AAAGGGTGCCATGGAGGAACTGG	SMAD5	ENSG00000113658	0.280993477646339	[]	[]	4	hSpCas9	negative selection	2920089
136153924	136153947	5	-	27260157	SF268	viability	CGGCTGTCCTGGACTGCTCAAGG	SMAD5	ENSG00000113658	1.0732244469429	[]	[]	9	hSpCas9	negative selection	2920254
136153801	136153824	5	+	27260157	SF268	viability	CAGTAAAGCGATTGTTGGGCTGG	SMAD5	ENSG00000113658	0.0385002095082236	[]	[]	0	hSpCas9	negative selection	2924247
136153797	136153820	5	-	27260157	SF268	viability	CCCAACAATCGCTTTACTGCTGG	SMAD5	ENSG00000113658	0.147321587274603	[]	[]	0	hSpCas9	negative selection	2926516
136153935	136153958	5	-	27260157	SF268	viability	ACACATTTACTCGGCTGTCCTGG	SMAD5	ENSG00000113658	0.406383215120792	[]	[]	4	hSpCas9	negative selection	2946293
136153796	136153819	5	+	27260157	SF268	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	0.30045122312685	[]	[]	4	hSpCas9	negative selection	2946745
136153817	136153840	5	+	27260157	SF268	viability	GGGCTGGAAACAAGGTGATGAGG	SMAD5	ENSG00000113658	-0.443797243908344	[]	[]	-3	hSpCas9	negative selection	2948961
136153986	136154009	5	+	27260157	SF268	viability	CTGCAGGTTTCTCACAGAAAAGG	SMAD5	ENSG00000113658	1.27799682877718	[]	[]	9	hSpCas9	negative selection	2949497
136153903	136153926	5	-	27260157	SF268	viability	GGCTTTCTCCAGTTCCTCCATGG	SMAD5	ENSG00000113658	0.620507960737958	[]	[]	8	hSpCas9	negative selection	2952220
136153751	136153774	5	+	27260157	SF268	viability	TTTGTGTCAAATGACGTCAATGG	SMAD5	ENSG00000113658	0.830242994985842	[]	[]	8	hSpCas9	negative selection	2953463
136160908	136160931	5	-	27383988	293T	resistance to West Nile virus (flavivirus)	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	1.257326211445835	[63,63]	[0,0]	5	hSpCas9	positive selection	3393747
136147891	136147914	5	-	27383988	293T	resistance to West Nile virus (flavivirus)	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	-1.494217847643263	[430,430]	[0,0]	-8	hSpCas9	positive selection	3393748
136152728	136152751	5	+	27383988	293T	resistance to West Nile virus (flavivirus)	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.3625084481378915	[237,237]	[1,1]	1	hSpCas9	positive selection	3393749
136152728	136152751	5	+	26780180	A375	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.714342731209912	[]	[]	2	hSpCas9	negative selection	3997012
136160876	136160899	5	-	26780180	A375	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	1.14026560247714	[]	[]	6	hSpCas9	negative selection	3997013
136160908	136160931	5	-	26780180	A375	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.887138582886159	[]	[]	4	hSpCas9	negative selection	3997014
136147891	136147914	5	-	26780180	A375	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	1.21097778208029	[]	[]	6	hSpCas9	negative selection	3997015
136154060	136154083	5	+	26780180	A375	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	1.71221313912999	[]	[]	9	hSpCas9	negative selection	3997016
136153796	136153819	5	+	26780180	A375	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	1.61976348673946	[]	[]	8	hSpCas9	negative selection	3997017
136152728	136152751	5	+	26780180	HT29	viability (GeCKOv2 library)	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.941001535870846	[]	[]	4	hSpCas9	negative selection	4104978
136160876	136160899	5	-	26780180	HT29	viability (GeCKOv2 library)	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	0.695741435785855	[]	[]	2	hSpCas9	negative selection	4104979
136160908	136160931	5	-	26780180	HT29	viability (GeCKOv2 library)	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.81025541077191	[]	[]	3	hSpCas9	negative selection	4104980
136147891	136147914	5	-	26780180	HT29	viability (GeCKOv2 library)	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	1.48222959975066	[]	[]	7	hSpCas9	negative selection	4104981
136154060	136154083	5	+	26780180	HT29	viability (GeCKOv2 library)	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	1.22386874669358	[]	[]	6	hSpCas9	negative selection	4104982
136153796	136153819	5	+	26780180	HT29	viability (GeCKOv2 library)	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	1.45328085991602	[]	[]	7	hSpCas9	negative selection	4104983
136153796	136153819	5	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	0.25704728992694226	[3]	[2,3]	5	hSpCas9	positive selection	4299210
136160876	136160899	5	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	0.44512684791414875	[3]	[3,3]	8	hSpCas9	positive selection	4299211
136154060	136154083	5	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.4825485104374876	[3]	[2,1]	-8	hSpCas9	positive selection	4299212
136160908	136160931	5	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	1.0156127711328842	[1]	[2,4]	9	hSpCas9	positive selection	4363463
136147891	136147914	5	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	-0.17988252500731275	[3]	[3,1]	-4	hSpCas9	positive selection	4363464
136152728	136152751	5	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.11214532336109377	[3]	[3,2]	2	hSpCas9	positive selection	4363465
136153796	136153819	5	+	27260156	BXPC3	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.12349814867802628	[647]	[587,498,659,765]	-3	hSpCas9	negative selection	5571670
136160876	136160899	5	-	27260156	BXPC3	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	0.10391718123741861	[521]	[526,621,535,670]	2	hSpCas9	negative selection	5571671
136154060	136154083	5	+	27260156	BXPC3	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.2868150252831732	[660]	[516,451,679,635]	-6	hSpCas9	negative selection	5571672
136160908	136160931	5	-	27260156	BXPC3	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.0667176422907867	[163]	[153,171,239,151]	1	hSpCas9	negative selection	5635923
136147891	136147914	5	-	27260156	BXPC3	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.15584422655771069	[974]	[964,1091,1130,1400]	3	hSpCas9	negative selection	5635924
136152728	136152751	5	+	27260156	BXPC3	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.04805333687999508	[569]	[567,561,647,701]	1	hSpCas9	negative selection	5635925
136153796	136153819	5	+	27260156	A673	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.014672735168075768	[647]	[857,813,593,826]	0	hSpCas9	negative selection	5692921
136160876	136160899	5	-	27260156	A673	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	0.19516495856872618	[521]	[614,714,826,697]	4	hSpCas9	negative selection	5692922
136154060	136154083	5	+	27260156	A673	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	0.056054960363640105	[660]	[803,775,761,963]	1	hSpCas9	negative selection	5692923
136160908	136160931	5	-	27260156	A673	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.3779696153879679	[163]	[290,274,191,269]	8	hSpCas9	negative selection	5757174
136147891	136147914	5	-	27260156	A673	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.06606733940481213	[974]	[1492,1187,1135,1108]	1	hSpCas9	negative selection	5757175
136152728	136152751	5	+	27260156	A673	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	-0.019265777769345183	[569]	[689,793,522,693]	0	hSpCas9	negative selection	5757176
136153796	136153819	5	+	27260156	A375	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.26502703649990017	[647]	[598,627,553,723]	-4	hSpCas9	negative selection	5814172
136160876	136160899	5	-	27260156	A375	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	0.030433298818090815	[521]	[593,761,625,535]	0	hSpCas9	negative selection	5814173
136154060	136154083	5	+	27260156	A375	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.3079922354083928	[660]	[627,503,696,643]	-4	hSpCas9	negative selection	5814174
136160908	136160931	5	-	27260156	A375	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.6698109418917446	[163]	[107,201,48,131]	-7	hSpCas9	negative selection	5878425
136147891	136147914	5	-	27260156	A375	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.5916186631364879	[974]	[1675,2103,1615,1536]	8	hSpCas9	negative selection	5878426
136152728	136152751	5	+	27260156	A375	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.5351250904932745	[569]	[800,1048,1044,969]	7	hSpCas9	negative selection	5878427
136153796	136153819	5	+	27260156	COLO741	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.4413225818458452	[647]	[658,702,479]	-7	hSpCas9	negative selection	5935423
136160876	136160899	5	-	27260156	COLO741	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	0.3444298851756945	[521]	[838,1006,702]	7	hSpCas9	negative selection	5935424
136154060	136154083	5	+	27260156	COLO741	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	0.030916180725436226	[660]	[1075,814,723]	0	hSpCas9	negative selection	5935425
136160908	136160931	5	-	27260156	COLO741	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.2597867196850667	[163]	[243,304,205]	5	hSpCas9	negative selection	5999676
136147891	136147914	5	-	27260156	COLO741	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.12200078942541248	[974]	[1581,1454,1067]	2	hSpCas9	negative selection	5999677
136152728	136152751	5	+	27260156	COLO741	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.3196960037065108	[569]	[932,956,841]	6	hSpCas9	negative selection	5999678
136153796	136153819	5	+	27260156	CAL120	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.5621909956920086	[647]	[771,457,443]	-7	hSpCas9	negative selection	6056674
136160876	136160899	5	-	27260156	CAL120	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	0.2862947925577294	[521]	[1281,440,727]	4	hSpCas9	negative selection	6056675
136154060	136154083	5	+	27260156	CAL120	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.03661136154186495	[660]	[781,848,771]	0	hSpCas9	negative selection	6056676
136160908	136160931	5	-	27260156	CAL120	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.012236092082664074	[163]	[239,189,182]	0	hSpCas9	negative selection	6120927
136147891	136147914	5	-	27260156	CAL120	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.06405441598285977	[974]	[1234,1489,1077]	1	hSpCas9	negative selection	6120928
136152728	136152751	5	+	27260156	CAL120	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.5198345705919414	[569]	[854,920,1245]	7	hSpCas9	negative selection	6120929
136153796	136153819	5	+	27260156	CADOES1	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.4254155418912595	[647]	[378,398,494,524]	-6	hSpCas9	negative selection	6177925
136160876	136160899	5	-	27260156	CADOES1	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	0.3749512459699764	[521]	[686,661,571,595]	6	hSpCas9	negative selection	6177926
136154060	136154083	5	+	27260156	CADOES1	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.12017202293475515	[660]	[605,561,488,606]	-2	hSpCas9	negative selection	6177927
136160908	136160931	5	-	27260156	CADOES1	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.10524816740820131	[163]	[124,203,149,177]	1	hSpCas9	negative selection	6242178
136147891	136147914	5	-	27260156	CADOES1	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.26604630246928496	[974]	[1107,945,1226,1079]	4	hSpCas9	negative selection	6242179
136152728	136152751	5	+	27260156	CADOES1	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.2898449139451203	[569]	[626,605,642,718]	5	hSpCas9	negative selection	6242180
136153796	136153819	5	+	27260156	EWS502	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.2003561133673728	[647]	[525,624,667,574]	-4	hSpCas9	negative selection	6299176
136160876	136160899	5	-	27260156	EWS502	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	-0.07398741395545252	[521]	[521,550,514,508]	-1	hSpCas9	negative selection	6299177
136154060	136154083	5	+	27260156	EWS502	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.3171940034696815	[660]	[456,605,607,587]	-5	hSpCas9	negative selection	6299178
136160908	136160931	5	-	27260156	EWS502	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.21993195202113003	[163]	[147,150,248,274]	4	hSpCas9	negative selection	6363429
136147891	136147914	5	-	27260156	EWS502	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.24546165750806592	[974]	[1332,1203,1073,1269]	4	hSpCas9	negative selection	6363430
136152728	136152751	5	+	27260156	EWS502	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.3208573838056598	[569]	[761,633,804,821]	5	hSpCas9	negative selection	6363431
136153796	136153819	5	+	27260156	EW8	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.2929300860032943	[647]	[504,440,338,451]	-5	hSpCas9	negative selection	6420427
136160876	136160899	5	-	27260156	EW8	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	-0.33908296040223596	[521]	[323,381,297,337]	-6	hSpCas9	negative selection	6420428
136154060	136154083	5	+	27260156	EW8	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.34106801940857745	[660]	[398,446,373,475]	-6	hSpCas9	negative selection	6420429
136160908	136160931	5	-	27260156	EW8	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.20561905552438886	[163]	[149,114,152,193]	4	hSpCas9	negative selection	6484680
136147891	136147914	5	-	27260156	EW8	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.11571370754512644	[974]	[941,819,714,977]	2	hSpCas9	negative selection	6484681
136152728	136152751	5	+	27260156	EW8	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.18262709565771007	[569]	[585,513,400,621]	3	hSpCas9	negative selection	6484682
136153796	136153819	5	+	27260156	CORL105	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	0.0915758882573699	[647]	[676,923,944,701]	1	hSpCas9	negative selection	6541678
136160876	136160899	5	-	27260156	CORL105	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	-0.10653529787201603	[521]	[526,409,635,708]	-2	hSpCas9	negative selection	6541679
136154060	136154083	5	+	27260156	CORL105	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	0.24397121594014703	[660]	[647,1067,1068,891]	4	hSpCas9	negative selection	6541680
136160908	136160931	5	-	27260156	CORL105	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.2717744167538261	[163]	[288,163,360,136]	5	hSpCas9	negative selection	6605931
136147891	136147914	5	-	27260156	CORL105	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.19283309720240593	[974]	[1204,1188,1647,1228]	3	hSpCas9	negative selection	6605932
136152728	136152751	5	+	27260156	CORL105	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	-0.16963892386368343	[569]	[548,588,666,577]	-3	hSpCas9	negative selection	6605933
136153796	136153819	5	+	27260156	HS294T	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	0.07223879409885386	[647]	[186,325,241,310]	1	hSpCas9	negative selection	6662929
136160876	136160899	5	-	27260156	HS294T	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	-0.047743109497601785	[521]	[223,181,146,230]	0	hSpCas9	negative selection	6662930
136154060	136154083	5	+	27260156	HS294T	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	0.30816516297321006	[660]	[141,411,254,499]	4	hSpCas9	negative selection	6662931
136160908	136160931	5	-	27260156	HS294T	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.17357248813315174	[163]	[23,69,73,59]	-2	hSpCas9	negative selection	6727182
136147891	136147914	5	-	27260156	HS294T	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	-0.0656249921621207	[974]	[310,396,370,364]	-1	hSpCas9	negative selection	6727183
136152728	136152751	5	+	27260156	HS294T	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.40956461967438434	[569]	[270,325,270,304]	5	hSpCas9	negative selection	6727184
136153796	136153819	5	+	27260156	HCC44	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.014506902755177964	[647]	[875,507,822,749]	0	hSpCas9	negative selection	6784180
136160876	136160899	5	-	27260156	HCC44	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	0.45444820560196175	[521]	[640,948,661,912]	7	hSpCas9	negative selection	6784181
136154060	136154083	5	+	27260156	HCC44	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	0.12036217102429103	[660]	[1006,694,837,744]	2	hSpCas9	negative selection	6784182
136160908	136160931	5	-	27260156	HCC44	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.3242423247342827	[163]	[212,220,327,182]	5	hSpCas9	negative selection	6848433
136147891	136147914	5	-	27260156	HCC44	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.2705175415047274	[974]	[1365,1467,1401,1077]	4	hSpCas9	negative selection	6848434
136152728	136152751	5	+	27260156	HCC44	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.21768008666377198	[569]	[874,614,869,685]	3	hSpCas9	negative selection	6848435
136153796	136153819	5	+	27260156	G402	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	0.1367637774855523	[647]	[929,856,1017,685]	1	hSpCas9	negative selection	6905431
136160876	136160899	5	-	27260156	G402	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	1.0724170045184052	[521]	[883,1562,1833,1033]	9	hSpCas9	negative selection	6905432
136154060	136154083	5	+	27260156	G402	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	0.15498041657934458	[660]	[1639,387,631,1000]	2	hSpCas9	negative selection	6905433
136160908	136160931	5	-	27260156	G402	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.1555086109019661	[163]	[210,173,132,202]	-2	hSpCas9	negative selection	6969684
136147891	136147914	5	-	27260156	G402	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.6602560798968315	[974]	[2331,1201,1443,2528]	7	hSpCas9	negative selection	6969685
136152728	136152751	5	+	27260156	G402	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.2246948988145771	[569]	[1091,501,565,1095]	3	hSpCas9	negative selection	6969686
136153796	136153819	5	+	27260156	L33	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	0.05824325039218853	[647]	[570,303,436,692]	1	hSpCas9	negative selection	7026682
136160876	136160899	5	-	27260156	L33	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	-0.125557259049423	[521]	[376,218,338,465]	-3	hSpCas9	negative selection	7026683
136154060	136154083	5	+	27260156	L33	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	0.17426682856166942	[660]	[694,277,517,786]	4	hSpCas9	negative selection	7026684
136160908	136160931	5	-	27260156	L33	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.38119306848942647	[163]	[111,49,87,129]	-7	hSpCas9	negative selection	7090935
136147891	136147914	5	-	27260156	L33	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	-0.25824271836143364	[974]	[812,360,507,758]	-5	hSpCas9	negative selection	7090936
136152728	136152751	5	+	27260156	L33	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	-0.18393946629030633	[569]	[440,239,377,381]	-4	hSpCas9	negative selection	7090937
136153796	136153819	5	+	27260156	K562	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.15453643576471926	[647]	[464,498,538,551]	-2	hSpCas9	negative selection	7147933
136160876	136160899	5	-	27260156	K562	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	0.05904523514528692	[521]	[519,496,289,609]	0	hSpCas9	negative selection	7147934
136154060	136154083	5	+	27260156	K562	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	0.06437972406868175	[660]	[729,686,742,336]	0	hSpCas9	negative selection	7147935
136160908	136160931	5	-	27260156	K562	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.6296932403696511	[163]	[331,148,268,161]	7	hSpCas9	negative selection	7212186
136147891	136147914	5	-	27260156	K562	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.356918290106341	[974]	[1191,1306,1186,795]	4	hSpCas9	negative selection	7212187
136152728	136152751	5	+	27260156	K562	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.15669053069452615	[569]	[672,446,629,511]	2	hSpCas9	negative selection	7212188
136153796	136153819	5	+	27260156	HT29	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.22081184884822988	[647]	[804,657,844,429]	-4	hSpCas9	negative selection	7269184
136160876	136160899	5	-	27260156	HT29	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	0.226977852868748	[521]	[801,733,689,742]	4	hSpCas9	negative selection	7269185
136154060	136154083	5	+	27260156	HT29	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.13036148743242754	[660]	[878,639,751,670]	-3	hSpCas9	negative selection	7269186
136160908	136160931	5	-	27260156	HT29	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.33953939135780575	[163]	[308,266,230,210]	6	hSpCas9	negative selection	7333437
136147891	136147914	5	-	27260156	HT29	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.16687828384690118	[974]	[1315,1362,1580,1084]	3	hSpCas9	negative selection	7333438
136152728	136152751	5	+	27260156	HT29	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.06534895372275357	[569]	[662,768,765,698]	1	hSpCas9	negative selection	7333439
136153796	136153819	5	+	27260156	MHHES1	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.27933698513434435	[647]	[800,780,569,342]	-5	hSpCas9	negative selection	7390435
136160876	136160899	5	-	27260156	MHHES1	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	0.16848019770933326	[521]	[801,703,810,395]	3	hSpCas9	negative selection	7390436
136154060	136154083	5	+	27260156	MHHES1	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.2756878630255032	[660]	[607,688,495,649]	-5	hSpCas9	negative selection	7390437
136160908	136160931	5	-	27260156	MHHES1	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.4184493378643841	[163]	[375,129,245,235]	7	hSpCas9	negative selection	7454688
136147891	136147914	5	-	27260156	MHHES1	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.1909413709661254	[974]	[1806,1272,1014,1013]	3	hSpCas9	negative selection	7454689
136152728	136152751	5	+	27260156	MHHES1	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.07111985671176024	[569]	[866,649,658,554]	1	hSpCas9	negative selection	7454690
136153796	136153819	5	+	27260156	MEWO	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.23605880998917494	[647]	[517,459,566]	-5	hSpCas9	negative selection	7511686
136160876	136160899	5	-	27260156	MEWO	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	0.23431430787213575	[521]	[602,543,581]	5	hSpCas9	negative selection	7511687
136154060	136154083	5	+	27260156	MEWO	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.2624498173146258	[660]	[595,538,426]	-5	hSpCas9	negative selection	7511688
136160908	136160931	5	-	27260156	MEWO	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.11417054219192191	[163]	[170,190,136]	2	hSpCas9	negative selection	7575939
136147891	136147914	5	-	27260156	MEWO	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.18730978793671427	[974]	[1261,822,1074]	4	hSpCas9	negative selection	7575940
136152728	136152751	5	+	27260156	MEWO	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	-0.11263059451534702	[569]	[588,515,392]	-2	hSpCas9	negative selection	7575941
136153796	136153819	5	+	27260156	LNCAPCLONEFGC	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.5942310267732211	[647]	[443,396,412,302]	-7	hSpCas9	negative selection	7632937
136160876	136160899	5	-	27260156	LNCAPCLONEFGC	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	0.057720638015276576	[521]	[472,526,455,504]	0	hSpCas9	negative selection	7632938
136154060	136154083	5	+	27260156	LNCAPCLONEFGC	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.3388951817828192	[660]	[482,414,506,496]	-5	hSpCas9	negative selection	7632939
136160908	136160931	5	-	27260156	LNCAPCLONEFGC	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.025742074017812255	[163]	[110,201,135,150]	0	hSpCas9	negative selection	7697190
136147891	136147914	5	-	27260156	LNCAPCLONEFGC	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.4343241241131237	[974]	[1017,1172,1423,1196]	6	hSpCas9	negative selection	7697191
136152728	136152751	5	+	27260156	LNCAPCLONEFGC	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.4660029721878722	[569]	[467,708,1114,624]	7	hSpCas9	negative selection	7697192
136153796	136153819	5	+	27260156	PANC0327	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	0.22436123019561244	[647]	[578,525,762,832]	3	hSpCas9	negative selection	7754188
136160876	136160899	5	-	27260156	PANC0327	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	0.2149616696893522	[521]	[675,503,363,623]	3	hSpCas9	negative selection	7754189
136154060	136154083	5	+	27260156	PANC0327	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	0.16601470030684007	[660]	[513,765,996,332]	2	hSpCas9	negative selection	7754190
136160908	136160931	5	-	27260156	PANC0327	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.7609993705012998	[163]	[114,117,33,74]	-8	hSpCas9	negative selection	7818441
136147891	136147914	5	-	27260156	PANC0327	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.19561810687914605	[974]	[969,782,1336,902]	3	hSpCas9	negative selection	7818442
136152728	136152751	5	+	27260156	PANC0327	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	-0.05504373742167418	[569]	[560,248,464,710]	-1	hSpCas9	negative selection	7818443
136153796	136153819	5	+	27260156	NCIH2009	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	0.05852571843002102	[647]	[1088,711,1058]	0	hSpCas9	negative selection	7875439
136160876	136160899	5	-	27260156	NCIH2009	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	0.11587344387609755	[521]	[488,846,972]	1	hSpCas9	negative selection	7875440
136154060	136154083	5	+	27260156	NCIH2009	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.2551062956928405	[660]	[872,542,927]	-3	hSpCas9	negative selection	7875441
136160908	136160931	5	-	27260156	NCIH2009	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.07016531465704312	[163]	[366,253,124]	1	hSpCas9	negative selection	7939692
136147891	136147914	5	-	27260156	NCIH2009	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	1.5909432935009549	[974]	[1942,8176,1682]	9	hSpCas9	negative selection	7939693
136152728	136152751	5	+	27260156	NCIH2009	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	-0.0908888085378563	[569]	[857,680,725]	-1	hSpCas9	negative selection	7939694
136153796	136153819	5	+	27260156	NCIH1373	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	0.18499543960250692	[647]	[1038,490,1018,213]	1	hSpCas9	negative selection	7996690
136160876	136160899	5	-	27260156	NCIH1373	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	-0.2868556734012042	[521]	[401,523,604,93]	-3	hSpCas9	negative selection	7996691
136154060	136154083	5	+	27260156	NCIH1373	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.08258886238123475	[660]	[888,376,689,240]	-1	hSpCas9	negative selection	7996692
136160908	136160931	5	-	27260156	NCIH1373	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.0569822423105637	[163]	[122,290,128,36]	0	hSpCas9	negative selection	8060943
136147891	136147914	5	-	27260156	NCIH1373	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.2180018805405557	[974]	[1375,1193,1117,374]	2	hSpCas9	negative selection	8060944
136152728	136152751	5	+	27260156	NCIH1373	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.7394711896332211	[569]	[1109,734,1431,266]	7	hSpCas9	negative selection	8060945
136153796	136153819	5	+	27260156	PATU8902	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.7042028891122574	[647]	[450,561,727,408]	-6	hSpCas9	negative selection	8117941
136160876	136160899	5	-	27260156	PATU8902	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	-0.12518058895947776	[521]	[542,725,633,781]	-1	hSpCas9	negative selection	8117942
136154060	136154083	5	+	27260156	PATU8902	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.7364712419895971	[660]	[623,397,646,504]	-6	hSpCas9	negative selection	8117943
136160908	136160931	5	-	27260156	PATU8902	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.5826967516922644	[163]	[280,335,302,471]	6	hSpCas9	negative selection	8182194
136147891	136147914	5	-	27260156	PATU8902	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.9621368129654382	[974]	[2553,2034,2234,4004]	9	hSpCas9	negative selection	8182195
136152728	136152751	5	+	27260156	PATU8902	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.2004400144823737	[569]	[625,970,1198,755]	2	hSpCas9	negative selection	8182196
136153796	136153819	5	+	27260156	PANC1	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.3865212059452005	[647]	[440,517,383,378]	-6	hSpCas9	negative selection	8239192
136160876	136160899	5	-	27260156	PANC1	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	-0.30100820366737546	[521]	[287,536,394,280]	-5	hSpCas9	negative selection	8239193
136154060	136154083	5	+	27260156	PANC1	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.2725601523038564	[660]	[484,466,488,435]	-4	hSpCas9	negative selection	8239194
136160908	136160931	5	-	27260156	PANC1	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.8382584494371113	[163]	[123,61,56,67]	-8	hSpCas9	negative selection	8303445
136147891	136147914	5	-	27260156	PANC1	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.23811765392471496	[974]	[996,1168,876,935]	4	hSpCas9	negative selection	8303446
136152728	136152751	5	+	27260156	PANC1	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.24791833035302296	[569]	[485,822,617,460]	4	hSpCas9	negative selection	8303447
136153796	136153819	5	+	27260156	PANC0813	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.381513083179431	[647]	[789,574,535,460]	-5	hSpCas9	negative selection	8360443
136160876	136160899	5	-	27260156	PANC0813	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	0.0599371657806764	[521]	[640,683,564,663]	1	hSpCas9	negative selection	8360444
136154060	136154083	5	+	27260156	PANC0813	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.15797311851191753	[660]	[798,596,732,664]	-3	hSpCas9	negative selection	8360445
136160908	136160931	5	-	27260156	PANC0813	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.16498643114852563	[163]	[293,99,156,313]	2	hSpCas9	negative selection	8424696
136147891	136147914	5	-	27260156	PANC0813	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.2763593776318829	[974]	[1576,1321,1103,1549]	4	hSpCas9	negative selection	8424697
136152728	136152751	5	+	27260156	PANC0813	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.21303754566350158	[569]	[601,906,818,759]	3	hSpCas9	negative selection	8424698
136153796	136153819	5	+	27260156	RDES	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.32166879009941096	[647]	[506,555,705,629]	-5	hSpCas9	negative selection	8481694
136160876	136160899	5	-	27260156	RDES	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	0.048572891502342314	[521]	[565,530,528,896]	0	hSpCas9	negative selection	8481695
136154060	136154083	5	+	27260156	RDES	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.06566534206191388	[660]	[606,690,764,872]	-1	hSpCas9	negative selection	8481696
136160908	136160931	5	-	27260156	RDES	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.1692933935673928	[163]	[135,99,212,243]	-3	hSpCas9	negative selection	8545947
136147891	136147914	5	-	27260156	RDES	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.40640064315016655	[974]	[1180,1248,1640,2003]	6	hSpCas9	negative selection	8545948
136152728	136152751	5	+	27260156	RDES	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.45912763839296006	[569]	[799,898,964,941]	7	hSpCas9	negative selection	8545949
136153796	136153819	5	+	27260156	PC3	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	0.018318054475592094	[647]	[359,614,1115,785]	0	hSpCas9	negative selection	8602945
136160876	136160899	5	-	27260156	PC3	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	-0.0591191933881931	[521]	[446,385,744,476]	-1	hSpCas9	negative selection	8602946
136154060	136154083	5	+	27260156	PC3	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	0.06520758168245111	[660]	[459,491,1395,728]	1	hSpCas9	negative selection	8602947
136160908	136160931	5	-	27260156	PC3	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.05081849049094522	[163]	[88,110,288,263]	1	hSpCas9	negative selection	8667198
136147891	136147914	5	-	27260156	PC3	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.11316399794179688	[974]	[617,1114,1617,1167]	2	hSpCas9	negative selection	8667199
136152728	136152751	5	+	27260156	PC3	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.08095675964985999	[569]	[330,463,1312,650]	1	hSpCas9	negative selection	8667200
136153796	136153819	5	+	27260156	PATU8988T	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.18854083372796	[647]	[440,540,539,685]	-3	hSpCas9	negative selection	8724196
136160876	136160899	5	-	27260156	PATU8988T	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	0.2427882408311034	[521]	[555,914,415,526]	4	hSpCas9	negative selection	8724197
136154060	136154083	5	+	27260156	PATU8988T	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.6315179553090245	[660]	[280,507,352,525]	-7	hSpCas9	negative selection	8724198
136160908	136160931	5	-	27260156	PATU8988T	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.15702683497754943	[163]	[56,106,233,167]	-3	hSpCas9	negative selection	8788449
136147891	136147914	5	-	27260156	PATU8988T	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	-0.09469211215174311	[974]	[867,995,802,872]	-2	hSpCas9	negative selection	8788450
136152728	136152751	5	+	27260156	PATU8988T	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	-0.2657944175319327	[569]	[310,476,491,561]	-4	hSpCas9	negative selection	8788451
136153796	136153819	5	+	27260156	T47D	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.21162056009657132	[647]	[672,571,644,726]	-5	hSpCas9	negative selection	8845447
136160876	136160899	5	-	27260156	T47D	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	-0.09009126144077127	[521]	[568,554,613,546]	-2	hSpCas9	negative selection	8845448
136154060	136154083	5	+	27260156	T47D	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.08000806386680048	[660]	[761,779,697,667]	-2	hSpCas9	negative selection	8845449
136160908	136160931	5	-	27260156	T47D	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.09054880382151809	[163]	[205,183,202,222]	2	hSpCas9	negative selection	8909700
136147891	136147914	5	-	27260156	T47D	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.09873887321916963	[974]	[1232,1110,1283,1245]	2	hSpCas9	negative selection	8909701
136152728	136152751	5	+	27260156	T47D	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.016205083703695444	[569]	[717,536,694,749]	0	hSpCas9	negative selection	8909702
136153796	136153819	5	+	27260156	SU8686	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.04571986400868239	[647]	[587,589,595,736]	-1	hSpCas9	negative selection	8966698
136160876	136160899	5	-	27260156	SU8686	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	-0.21520038415972076	[521]	[520,347,492,418]	-4	hSpCas9	negative selection	8966699
136154060	136154083	5	+	27260156	SU8686	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.2138776356320879	[660]	[580,524,538,622]	-4	hSpCas9	negative selection	8966700
136160908	136160931	5	-	27260156	SU8686	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.21653472625424142	[163]	[161,104,129,167]	-4	hSpCas9	negative selection	9030951
136147891	136147914	5	-	27260156	SU8686	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.2888604284719387	[974]	[965,1017,1312,1522]	5	hSpCas9	negative selection	9030952
136152728	136152751	5	+	27260156	SU8686	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.2064202545475914	[569]	[653,487,807,683]	3	hSpCas9	negative selection	9030953
136153796	136153819	5	+	27260156	SKES1	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.47328341671390817	[647]	[440,594,504,342]	-8	hSpCas9	negative selection	9087949
136160876	136160899	5	-	27260156	SKES1	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	0.13330006090559832	[521]	[581,673,521,520]	3	hSpCas9	negative selection	9087950
136154060	136154083	5	+	27260156	SKES1	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.21972198587411573	[660]	[792,789,354,401]	-5	hSpCas9	negative selection	9087951
136160908	136160931	5	-	27260156	SKES1	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.07585514226394063	[163]	[170,276,127,129]	1	hSpCas9	negative selection	9152202
136147891	136147914	5	-	27260156	SKES1	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.1087524022372719	[974]	[1254,1204,897,893]	2	hSpCas9	negative selection	9152203
136152728	136152751	5	+	27260156	SKES1	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.12387684658421566	[569]	[746,663,530,560]	2	hSpCas9	negative selection	9152204
136153796	136153819	5	+	27260156	TOV112D	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.3761683639832069	[647]	[523,605,489,409]	-6	hSpCas9	negative selection	9209200
136160876	136160899	5	-	27260156	TOV112D	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	0.16234566192006472	[521]	[458,677,607,605]	3	hSpCas9	negative selection	9209201
136154060	136154083	5	+	27260156	TOV112D	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	0.05751241437674959	[660]	[619,681,424,1010]	1	hSpCas9	negative selection	9209202
136160908	136160931	5	-	27260156	TOV112D	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.06471992963501605	[163]	[71,227,208,129]	-1	hSpCas9	negative selection	9273453
136147891	136147914	5	-	27260156	TOV112D	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.043769866554550285	[974]	[1079,1087,951,932]	0	hSpCas9	negative selection	9273454
136152728	136152751	5	+	27260156	TOV112D	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	-0.1046564590788974	[569]	[491,569,528,537]	-2	hSpCas9	negative selection	9273455
136153796	136153819	5	+	27260156	TC71	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.11643838716223287	[647]	[686,578,579,722]	-3	hSpCas9	negative selection	9330451
136160876	136160899	5	-	27260156	TC71	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	0.14213186915737142	[521]	[534,753,540,645]	3	hSpCas9	negative selection	9330452
136154060	136154083	5	+	27260156	TC71	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.16787938632371274	[660]	[655,646,555,667]	-4	hSpCas9	negative selection	9330453
136160908	136160931	5	-	27260156	TC71	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.1186663978426632	[163]	[216,146,170,230]	3	hSpCas9	negative selection	9394704
136147891	136147914	5	-	27260156	TC71	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	-0.06630511989684695	[974]	[992,1024,1011,959]	-2	hSpCas9	negative selection	9394705
136152728	136152751	5	+	27260156	TC71	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	-0.07131001050037455	[569]	[693,529,545,552]	-2	hSpCas9	negative selection	9394706
136153796	136153819	5	+	27260156	TC32	viability	TCCAGCAGTAAAGCGATTGTTGG	SMAD5	ENSG00000113658	-0.31940905454275936	[647]	[462,329,578,638]	-5	hSpCas9	negative selection	9451702
136160876	136160899	5	-	27260156	TC32	viability	GGATTGAATTCATTATGACGAGG	SMAD5	ENSG00000113658	-0.13783010374242255	[521]	[398,372,565,473]	-2	hSpCas9	negative selection	9451703
136154060	136154083	5	+	27260156	TC32	viability	TCATCATGAGCTAAAGCCGTTGG	SMAD5	ENSG00000113658	-0.23490881042202838	[660]	[562,252,779,635]	-4	hSpCas9	negative selection	9451704
136160908	136160931	5	-	27260156	TC32	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.34737181023058605	[163]	[96,118,120,144]	-6	hSpCas9	negative selection	9515955
136147891	136147914	5	-	27260156	TC32	viability	TACTTACAGAGGCAGATTTCTGG	SMAD5	ENSG00000113658	0.4882896307899256	[974]	[1143,1074,1622,1381]	8	hSpCas9	negative selection	9515956
136152728	136152751	5	+	27260156	TC32	viability	AAGTGAGTCTCCCGAATAACTGG	SMAD5	ENSG00000113658	0.08528825839851639	[569]	[498,415,780,651]	1	hSpCas9	negative selection	9515957
136154023	136154046	5	+	27869803	HPAFII	viability after 27 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	-0.1155956868260779	[73]	[42,29,NaN]	-1	hSpCas9	negative selection	9590057
136160908	136160931	5	-	27869803	HPAFII	viability after 27 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.6786925525908649	[61]	[21,18,NaN]	-5	hSpCas9	negative selection	9590058
136163283	136163306	5	-	27869803	HPAFII	viability after 27 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	-0.1298934920267398	[276]	[95,163,NaN]	-1	hSpCas9	negative selection	9590059
136163298	136163321	5	-	27869803	HPAFII	viability after 27 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	0.4333380719115917	[193]	[110,159,NaN]	3	hSpCas9	negative selection	9590060
136172442	136172465	5	-	27869803	HPAFII	viability after 27 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	-0.6771612397747041	[226]	[42,100,NaN]	-5	hSpCas9	negative selection	9590061
136174569	136174592	5	-	27869803	HPAFII	viability after 27 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	-4.438741759870112	[59]	[1,0,NaN]	-9	hSpCas9	negative selection	9590062
136154023	136154046	5	+	27869803	HPAFII	viability after 15 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	0.34838820983790075	[73]	[128,83,NaN]	4	hSpCas9	negative selection	9672506
136160908	136160931	5	-	27869803	HPAFII	viability after 15 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.3167512520998321	[61]	[34,64,NaN]	-4	hSpCas9	negative selection	9672507
136163283	136163306	5	-	27869803	HPAFII	viability after 15 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	-0.056873994147457765	[276]	[382,225,NaN]	0	hSpCas9	negative selection	9672508
136163298	136163321	5	-	27869803	HPAFII	viability after 15 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	-0.23692975479221967	[193]	[216,151,NaN]	-3	hSpCas9	negative selection	9672509
136172442	136172465	5	-	27869803	HPAFII	viability after 15 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	0.12016235471726433	[226]	[303,240,NaN]	1	hSpCas9	negative selection	9672510
136174569	136174592	5	-	27869803	HPAFII	viability after 15 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	-3.3401398263810305	[59]	[14,0,NaN]	-9	hSpCas9	negative selection	9672511
136154023	136154046	5	+	27869803	ASPC1	viability after 36 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	0.2540524818526071	[393]	[229,95,169]	2	hSpCas9	negative selection	9754955
136160908	136160931	5	-	27869803	ASPC1	viability after 36 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.3492341895339588	[67]	[28,0,53]	3	hSpCas9	negative selection	9754956
136163283	136163306	5	-	27869803	ASPC1	viability after 36 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	0.5836340022860675	[684]	[459,238,377]	6	hSpCas9	negative selection	9754957
136163298	136163321	5	-	27869803	ASPC1	viability after 36 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	-1.3268395882099837	[471]	[19,100,68]	-8	hSpCas9	negative selection	9754958
136172442	136172465	5	-	27869803	ASPC1	viability after 36 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	0.6035557478129718	[588]	[510,291,185]	6	hSpCas9	negative selection	9754959
136174569	136174592	5	-	27869803	ASPC1	viability after 36 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	-1.6677087178794632	[77]	[12,3,8]	-9	hSpCas9	negative selection	9754960
136154023	136154046	5	+	27869803	PATU8988S	viability after 35 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	1.3415761254388603	[188]	[152,232,NaN]	9	hSpCas9	negative selection	9837404
136160908	136160931	5	-	27869803	PATU8988S	viability after 35 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.1805104549263956	[75]	[30,22,NaN]	-2	hSpCas9	negative selection	9837405
136163283	136163306	5	-	27869803	PATU8988S	viability after 35 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	-0.68975386435432	[700]	[188,160,NaN]	-6	hSpCas9	negative selection	9837406
136163298	136163321	5	-	27869803	PATU8988S	viability after 35 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	0.03869263658524058	[312]	[123,134,NaN]	0	hSpCas9	negative selection	9837407
136172442	136172465	5	-	27869803	PATU8988S	viability after 35 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	-0.032940107231607375	[581]	[276,180,NaN]	0	hSpCas9	negative selection	9837408
136174569	136174592	5	-	27869803	PATU8988S	viability after 35 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	0.8693560012323802	[52]	[36,40,NaN]	8	hSpCas9	negative selection	9837409
136154023	136154046	5	+	27869803	PATU8988S	viability after 31 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	0.9484591747019492	[188]	[122,173,NaN]	9	hSpCas9	negative selection	9919853
136160908	136160931	5	-	27869803	PATU8988S	viability after 31 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.26847312046672833	[75]	[18,32,NaN]	-3	hSpCas9	negative selection	9919854
136163283	136163306	5	-	27869803	PATU8988S	viability after 31 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	-0.9068447289849666	[700]	[156,138,NaN]	-7	hSpCas9	negative selection	9919855
136163298	136163321	5	-	27869803	PATU8988S	viability after 31 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	-0.13984503678242644	[312]	[96,133,NaN]	-1	hSpCas9	negative selection	9919856
136172442	136172465	5	-	27869803	PATU8988S	viability after 31 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	0.194252309305032	[581]	[250,283,NaN]	2	hSpCas9	negative selection	9919857
136174569	136174592	5	-	27869803	PATU8988S	viability after 31 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	1.5054373324953232	[52]	[59,59,NaN]	9	hSpCas9	negative selection	9919858
136154023	136154046	5	+	27869803	HPAFII	viability after 35 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	0.6202558480362546	[73]	[50,64,NaN]	4	hSpCas9	negative selection	10002302
136160908	136160931	5	-	27869803	HPAFII	viability after 35 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.9258141051162649	[61]	[0,33,NaN]	-5	hSpCas9	negative selection	10002303
136163283	136163306	5	-	27869803	HPAFII	viability after 35 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	-0.3657729934211943	[276]	[113,102,NaN]	-2	hSpCas9	negative selection	10002304
136163298	136163321	5	-	27869803	HPAFII	viability after 35 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	0.5062765839565377	[193]	[75,210,NaN]	3	hSpCas9	negative selection	10002305
136172442	136172465	5	-	27869803	HPAFII	viability after 35 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	-1.5123039467322494	[226]	[20,61,NaN]	-7	hSpCas9	negative selection	10002306
136174569	136174592	5	-	27869803	HPAFII	viability after 35 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	-4.924802042611844	[59]	[0,0,NaN]	-9	hSpCas9	negative selection	10002307
136154023	136154046	5	+	27869803	HPAFII	viability after 31 days	TATATTGTCGTGTTTGGCGCTGG	SMAD5	ENSG00000113658	0.9997020103332277	[73]	[83,81,NaN]	7	hSpCas9	negative selection	10084751
136160908	136160931	5	-	27869803	HPAFII	viability after 31 days	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.8788759992869619	[61]	[5,32,NaN]	-5	hSpCas9	negative selection	10084752
136163283	136163306	5	-	27869803	HPAFII	viability after 31 days	TCAGGTGGCATATAGGCAGGAGG	SMAD5	ENSG00000113658	0.21554115060014317	[276]	[135,228,NaN]	1	hSpCas9	negative selection	10084753
136163298	136163321	5	-	27869803	HPAFII	viability after 31 days	TGACCCATCTGATCATCAGGTGG	SMAD5	ENSG00000113658	0.5362604543845922	[193]	[121,196,NaN]	4	hSpCas9	negative selection	10084754
136172442	136172465	5	-	27869803	HPAFII	viability after 31 days	TTAGGCTCTTCATAGGCAACAGG	SMAD5	ENSG00000113658	-0.9246293065484269	[226]	[24,112,NaN]	-5	hSpCas9	negative selection	10084755
136174569	136174592	5	-	27869803	HPAFII	viability after 31 days	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	-3.714962379055176	[59]	[3,0,NaN]	-9	hSpCas9	negative selection	10084756
136174481	136174504	5	-	28162770	P31FUJ	viability	GGGAATCTTACAGACAGTGGTGG	SMAD5	ENSG00000113658	-0.5218870426147242	[1139]	[932]	-4	hSpCas9	negative selection	10238740
136172449	136172472	5	+	28162770	P31FUJ	viability	CCTATGAAGAGCCTAAACATTGG	SMAD5	ENSG00000113658	0.22448243970958393	[1833]	[2517]	2	hSpCas9	negative selection	10238741
136163361	136163384	5	-	28162770	P31FUJ	viability	GATATACTGGGCATAATCTGAGG	SMAD5	ENSG00000113658	0.3382747700518278	[695]	[1033]	3	hSpCas9	negative selection	10238742
136163280	136163303	5	-	28162770	P31FUJ	viability	GGTGGCATATAGGCAGGAGGAGG	SMAD5	ENSG00000113658	0.12288918484626654	[1494]	[1912]	1	hSpCas9	negative selection	10238743
136153817	136153840	5	+	28162770	P31FUJ	viability	GGGCTGGAAACAAGGTGATGAGG	SMAD5	ENSG00000113658	0.28238475061603907	[1644]	[2350]	3	hSpCas9	negative selection	10238744
136160861	136160884	5	-	28162770	P31FUJ	viability	TGACGAGGCACTAATACTGGAGG	SMAD5	ENSG00000113658	-0.20299339519832493	[478]	[488]	-2	hSpCas9	negative selection	10238745
136160908	136160931	5	-	28162770	P31FUJ	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.6473090600785396	[463]	[853]	7	hSpCas9	negative selection	10238746
136161033	136161056	5	-	28162770	P31FUJ	viability	TGTGCTGCTAGCAGGAGAAGGGG	SMAD5	ENSG00000113658	0.30005858279328335	[1606]	[2324]	3	hSpCas9	negative selection	10238747
136174569	136174592	5	-	28162770	P31FUJ	viability	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	0.3250666354245024	[429]	[632]	3	hSpCas9	negative selection	10238748
136153828	136153851	5	+	28162770	P31FUJ	viability	AAGGTGATGAGGAGGAGAAATGG	SMAD5	ENSG00000113658	-0.01968759666594133	[935]	[1084]	0	hSpCas9	negative selection	10238749
136174481	136174504	5	-	28162770	TF1	viability	GGGAATCTTACAGACAGTGGTGG	SMAD5	ENSG00000113658	NaN	[NaN]	[62]	1	hSpCas9	negative selection	10408106
136172449	136172472	5	+	28162770	TF1	viability	CCTATGAAGAGCCTAAACATTGG	SMAD5	ENSG00000113658	NaN	[NaN]	[297]	1	hSpCas9	negative selection	10408107
136163361	136163384	5	-	28162770	TF1	viability	GATATACTGGGCATAATCTGAGG	SMAD5	ENSG00000113658	NaN	[NaN]	[85]	1	hSpCas9	negative selection	10408108
136163280	136163303	5	-	28162770	TF1	viability	GGTGGCATATAGGCAGGAGGAGG	SMAD5	ENSG00000113658	NaN	[NaN]	[321]	1	hSpCas9	negative selection	10408109
136153817	136153840	5	+	28162770	TF1	viability	GGGCTGGAAACAAGGTGATGAGG	SMAD5	ENSG00000113658	NaN	[NaN]	[246]	1	hSpCas9	negative selection	10408110
136160861	136160884	5	-	28162770	TF1	viability	TGACGAGGCACTAATACTGGAGG	SMAD5	ENSG00000113658	NaN	[NaN]	[60]	1	hSpCas9	negative selection	10408111
136160908	136160931	5	-	28162770	TF1	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	NaN	[NaN]	[36]	1	hSpCas9	negative selection	10408112
136161033	136161056	5	-	28162770	TF1	viability	TGTGCTGCTAGCAGGAGAAGGGG	SMAD5	ENSG00000113658	NaN	[NaN]	[199]	1	hSpCas9	negative selection	10408113
136174569	136174592	5	-	28162770	TF1	viability	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	NaN	[NaN]	[155]	1	hSpCas9	negative selection	10408114
136153828	136153851	5	+	28162770	TF1	viability	AAGGTGATGAGGAGGAGAAATGG	SMAD5	ENSG00000113658	NaN	[NaN]	[149]	1	hSpCas9	negative selection	10408115
136174481	136174504	5	-	28162770	SKM1	viability	GGGAATCTTACAGACAGTGGTGG	SMAD5	ENSG00000113658	-0.78352755020737	[73]	[75]	-5	hSpCas9	negative selection	10577472
136172449	136172472	5	+	28162770	SKM1	viability	CCTATGAAGAGCCTAAACATTGG	SMAD5	ENSG00000113658	0.18764847201171375	[148]	[299]	1	hSpCas9	negative selection	10577473
136163361	136163384	5	-	28162770	SKM1	viability	GATATACTGGGCATAATCTGAGG	SMAD5	ENSG00000113658	0.20837195102151335	[46]	[95]	2	hSpCas9	negative selection	10577474
136163280	136163303	5	-	28162770	SKM1	viability	GGTGGCATATAGGCAGGAGGAGG	SMAD5	ENSG00000113658	0.07108309806148261	[97]	[181]	0	hSpCas9	negative selection	10577475
136153817	136153840	5	+	28162770	SKM1	viability	GGGCTGGAAACAAGGTGATGAGG	SMAD5	ENSG00000113658	0.004279727377236364	[118]	[210]	0	hSpCas9	negative selection	10577476
136160861	136160884	5	-	28162770	SKM1	viability	TGACGAGGCACTAATACTGGAGG	SMAD5	ENSG00000113658	-0.2814333166593027	[54]	[79]	-2	hSpCas9	negative selection	10577477
136160908	136160931	5	-	28162770	SKM1	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.24212863939771	[21]	[45]	2	hSpCas9	negative selection	10577478
136161033	136161056	5	-	28162770	SKM1	viability	TGTGCTGCTAGCAGGAGAAGGGG	SMAD5	ENSG00000113658	-0.28226845129384714	[107]	[156]	-2	hSpCas9	negative selection	10577479
136174569	136174592	5	-	28162770	SKM1	viability	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	0.5086436139664657	[32]	[82]	5	hSpCas9	negative selection	10577480
136153828	136153851	5	+	28162770	SKM1	viability	AAGGTGATGAGGAGGAGAAATGG	SMAD5	ENSG00000113658	0.8817970322090012	[65]	[214]	8	hSpCas9	negative selection	10577481
136174481	136174504	5	-	28162770	SKM1	viability	GGGAATCTTACAGACAGTGGTGG	SMAD5	ENSG00000113658	-0.78352755020737	[73]	[75]	-5	hSpCas9	negative selection	10746838
136172449	136172472	5	+	28162770	SKM1	viability	CCTATGAAGAGCCTAAACATTGG	SMAD5	ENSG00000113658	0.18764847201171375	[148]	[299]	1	hSpCas9	negative selection	10746839
136163361	136163384	5	-	28162770	SKM1	viability	GATATACTGGGCATAATCTGAGG	SMAD5	ENSG00000113658	0.20837195102151335	[46]	[95]	2	hSpCas9	negative selection	10746840
136163280	136163303	5	-	28162770	SKM1	viability	GGTGGCATATAGGCAGGAGGAGG	SMAD5	ENSG00000113658	0.07108309806148261	[97]	[181]	0	hSpCas9	negative selection	10746841
136153817	136153840	5	+	28162770	SKM1	viability	GGGCTGGAAACAAGGTGATGAGG	SMAD5	ENSG00000113658	0.004279727377236364	[118]	[210]	0	hSpCas9	negative selection	10746842
136160861	136160884	5	-	28162770	SKM1	viability	TGACGAGGCACTAATACTGGAGG	SMAD5	ENSG00000113658	-0.2814333166593027	[54]	[79]	-2	hSpCas9	negative selection	10746843
136160908	136160931	5	-	28162770	SKM1	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.24212863939771	[21]	[45]	2	hSpCas9	negative selection	10746844
136161033	136161056	5	-	28162770	SKM1	viability	TGTGCTGCTAGCAGGAGAAGGGG	SMAD5	ENSG00000113658	-0.28226845129384714	[107]	[156]	-2	hSpCas9	negative selection	10746845
136174569	136174592	5	-	28162770	SKM1	viability	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	0.5086436139664657	[32]	[82]	5	hSpCas9	negative selection	10746846
136153828	136153851	5	+	28162770	SKM1	viability	AAGGTGATGAGGAGGAGAAATGG	SMAD5	ENSG00000113658	0.8817970322090012	[65]	[214]	8	hSpCas9	negative selection	10746847
136174481	136174504	5	-	28162770	PL21	viability	GGGAATCTTACAGACAGTGGTGG	SMAD5	ENSG00000113658	0.5559934649023665	[310]	[198]	5	hSpCas9	negative selection	10916204
136172449	136172472	5	+	28162770	PL21	viability	CCTATGAAGAGCCTAAACATTGG	SMAD5	ENSG00000113658	-0.22470105981988253	[442]	[164]	-2	hSpCas9	negative selection	10916205
136163361	136163384	5	-	28162770	PL21	viability	GATATACTGGGCATAATCTGAGG	SMAD5	ENSG00000113658	0.48298250140329424	[216]	[131]	4	hSpCas9	negative selection	10916206
136163280	136163303	5	-	28162770	PL21	viability	GGTGGCATATAGGCAGGAGGAGG	SMAD5	ENSG00000113658	0.5317611055805265	[355]	[223]	4	hSpCas9	negative selection	10916207
136153817	136153840	5	+	28162770	PL21	viability	GGGCTGGAAACAAGGTGATGAGG	SMAD5	ENSG00000113658	-0.3494898131195553	[362]	[123]	-3	hSpCas9	negative selection	10916208
136160861	136160884	5	-	28162770	PL21	viability	TGACGAGGCACTAATACTGGAGG	SMAD5	ENSG00000113658	-0.03523844844160833	[185]	[78]	0	hSpCas9	negative selection	10916209
136160908	136160931	5	-	28162770	PL21	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.6607739802082747	[108]	[74]	6	hSpCas9	negative selection	10916210
136161033	136161056	5	-	28162770	PL21	viability	TGTGCTGCTAGCAGGAGAAGGGG	SMAD5	ENSG00000113658	0.9532700280865334	[425]	[358]	7	hSpCas9	negative selection	10916211
136174569	136174592	5	-	28162770	PL21	viability	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	0.3166536232157454	[106]	[57]	3	hSpCas9	negative selection	10916212
136153828	136153851	5	+	28162770	PL21	viability	AAGGTGATGAGGAGGAGAAATGG	SMAD5	ENSG00000113658	0.29411576269833384	[207]	[110]	2	hSpCas9	negative selection	10916213
136174481	136174504	5	-	28162770	P31FUJ	viability	GGGAATCTTACAGACAGTGGTGG	SMAD5	ENSG00000113658	-0.5218870426147242	[1139]	[932]	-4	hSpCas9	negative selection	11085570
136172449	136172472	5	+	28162770	P31FUJ	viability	CCTATGAAGAGCCTAAACATTGG	SMAD5	ENSG00000113658	0.22448243970958393	[1833]	[2517]	2	hSpCas9	negative selection	11085571
136163361	136163384	5	-	28162770	P31FUJ	viability	GATATACTGGGCATAATCTGAGG	SMAD5	ENSG00000113658	0.3382747700518278	[695]	[1033]	3	hSpCas9	negative selection	11085572
136163280	136163303	5	-	28162770	P31FUJ	viability	GGTGGCATATAGGCAGGAGGAGG	SMAD5	ENSG00000113658	0.12288918484626654	[1494]	[1912]	1	hSpCas9	negative selection	11085573
136153817	136153840	5	+	28162770	P31FUJ	viability	GGGCTGGAAACAAGGTGATGAGG	SMAD5	ENSG00000113658	0.28238475061603907	[1644]	[2350]	3	hSpCas9	negative selection	11085574
136160861	136160884	5	-	28162770	P31FUJ	viability	TGACGAGGCACTAATACTGGAGG	SMAD5	ENSG00000113658	-0.20299339519832493	[478]	[488]	-2	hSpCas9	negative selection	11085575
136160908	136160931	5	-	28162770	P31FUJ	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.6473090600785396	[463]	[853]	7	hSpCas9	negative selection	11085576
136161033	136161056	5	-	28162770	P31FUJ	viability	TGTGCTGCTAGCAGGAGAAGGGG	SMAD5	ENSG00000113658	0.30005858279328335	[1606]	[2324]	3	hSpCas9	negative selection	11085577
136174569	136174592	5	-	28162770	P31FUJ	viability	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	0.3250666354245024	[429]	[632]	3	hSpCas9	negative selection	11085578
136153828	136153851	5	+	28162770	P31FUJ	viability	AAGGTGATGAGGAGGAGAAATGG	SMAD5	ENSG00000113658	-0.01968759666594133	[935]	[1084]	0	hSpCas9	negative selection	11085579
136174481	136174504	5	-	28162770	OCIAML5	viability	GGGAATCTTACAGACAGTGGTGG	SMAD5	ENSG00000113658	-0.21793801333895635	[124]	[193]	-1	hSpCas9	negative selection	11254936
136172449	136172472	5	+	28162770	OCIAML5	viability	CCTATGAAGAGCCTAAACATTGG	SMAD5	ENSG00000113658	0.313519494853978	[221]	[497]	2	hSpCas9	negative selection	11254937
136163361	136163384	5	-	28162770	OCIAML5	viability	GATATACTGGGCATAATCTGAGG	SMAD5	ENSG00000113658	1.1862034460637203	[92]	[381]	8	hSpCas9	negative selection	11254938
136163280	136163303	5	-	28162770	OCIAML5	viability	GGTGGCATATAGGCAGGAGGAGG	SMAD5	ENSG00000113658	-0.4479527206213899	[231]	[306]	-3	hSpCas9	negative selection	11254939
136153817	136153840	5	+	28162770	OCIAML5	viability	GGGCTGGAAACAAGGTGATGAGG	SMAD5	ENSG00000113658	0.23452111413209364	[193]	[411]	2	hSpCas9	negative selection	11254940
136160861	136160884	5	-	28162770	OCIAML5	viability	TGACGAGGCACTAATACTGGAGG	SMAD5	ENSG00000113658	-0.044711648806393	[67]	[118]	0	hSpCas9	negative selection	11254941
136160908	136160931	5	-	28162770	OCIAML5	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	1.1717801710903708	[44]	[182]	8	hSpCas9	negative selection	11254942
136161033	136161056	5	-	28162770	OCIAML5	viability	TGTGCTGCTAGCAGGAGAAGGGG	SMAD5	ENSG00000113658	0.1891907666138397	[292]	[602]	1	hSpCas9	negative selection	11254943
136174569	136174592	5	-	28162770	OCIAML5	viability	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	1.0345516297182606	[42]	[158]	8	hSpCas9	negative selection	11254944
136153828	136153851	5	+	28162770	OCIAML5	viability	AAGGTGATGAGGAGGAGAAATGG	SMAD5	ENSG00000113658	0.6459602930858784	[113]	[321]	5	hSpCas9	negative selection	11254945
136174481	136174504	5	-	28162770	EOL1	viability	GGGAATCTTACAGACAGTGGTGG	SMAD5	ENSG00000113658	-0.501529534935251	[480]	[178]	-4	hSpCas9	negative selection	11424302
136172449	136172472	5	+	28162770	EOL1	viability	CCTATGAAGAGCCTAAACATTGG	SMAD5	ENSG00000113658	0.23379060682678166	[593]	[367]	2	hSpCas9	negative selection	11424303
136163361	136163384	5	-	28162770	EOL1	viability	GATATACTGGGCATAATCTGAGG	SMAD5	ENSG00000113658	0.23722355321970062	[218]	[135]	2	hSpCas9	negative selection	11424304
136163280	136163303	5	-	28162770	EOL1	viability	GGTGGCATATAGGCAGGAGGAGG	SMAD5	ENSG00000113658	2.236919698381591	[514]	[1278]	9	hSpCas9	negative selection	11424305
136153817	136153840	5	+	28162770	EOL1	viability	GGGCTGGAAACAAGGTGATGAGG	SMAD5	ENSG00000113658	1.277351314543637	[526]	[672]	9	hSpCas9	negative selection	11424306
136160861	136160884	5	-	28162770	EOL1	viability	TGACGAGGCACTAATACTGGAGG	SMAD5	ENSG00000113658	1.024083445121449	[167]	[179]	8	hSpCas9	negative selection	11424307
136160908	136160931	5	-	28162770	EOL1	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.4335614190583923	[103]	[73]	4	hSpCas9	negative selection	11424308
136161033	136161056	5	-	28162770	EOL1	viability	TGTGCTGCTAGCAGGAGAAGGGG	SMAD5	ENSG00000113658	-0.35200495843795343	[578]	[238]	-3	hSpCas9	negative selection	11424309
136174569	136174592	5	-	28162770	EOL1	viability	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	0.007009931762507526	[152]	[80]	0	hSpCas9	negative selection	11424310
136153828	136153851	5	+	28162770	EOL1	viability	AAGGTGATGAGGAGGAGAAATGG	SMAD5	ENSG00000113658	0.4423115724037907	[270]	[193]	4	hSpCas9	negative selection	11424311
136174481	136174504	5	-	28162770	MOLM13	viability	GGGAATCTTACAGACAGTGGTGG	SMAD5	ENSG00000113658	-0.6441156439685523	[414]	[191]	-4	hSpCas9	negative selection	11593668
136172449	136172472	5	+	28162770	MOLM13	viability	CCTATGAAGAGCCTAAACATTGG	SMAD5	ENSG00000113658	1.7197132379675928	[505]	[1204]	9	hSpCas9	negative selection	11593669
136163361	136163384	5	-	28162770	MOLM13	viability	GATATACTGGGCATAATCTGAGG	SMAD5	ENSG00000113658	0.8948995224894987	[269]	[362]	6	hSpCas9	negative selection	11593670
136163280	136163303	5	-	28162770	MOLM13	viability	GGTGGCATATAGGCAGGAGGAGG	SMAD5	ENSG00000113658	-0.1421641001394079	[405]	[265]	-1	hSpCas9	negative selection	11593671
136153817	136153840	5	+	28162770	MOLM13	viability	GGGCTGGAAACAAGGTGATGAGG	SMAD5	ENSG00000113658	0.8514257376094214	[462]	[603]	6	hSpCas9	negative selection	11593672
136160861	136160884	5	-	28162770	MOLM13	viability	TGACGAGGCACTAATACTGGAGG	SMAD5	ENSG00000113658	-0.3151235801410637	[190]	[110]	-2	hSpCas9	negative selection	11593673
136160908	136160931	5	-	28162770	MOLM13	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-1.0874479500672993	[240]	[81]	-5	hSpCas9	negative selection	11593674
136161033	136161056	5	-	28162770	MOLM13	viability	TGTGCTGCTAGCAGGAGAAGGGG	SMAD5	ENSG00000113658	0.34747833514384385	[536]	[493]	2	hSpCas9	negative selection	11593675
136174569	136174592	5	-	28162770	MOLM13	viability	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	0.7716701297216817	[127]	[157]	6	hSpCas9	negative selection	11593676
136153828	136153851	5	+	28162770	MOLM13	viability	AAGGTGATGAGGAGGAGAAATGG	SMAD5	ENSG00000113658	-0.8728703880731554	[346]	[136]	-5	hSpCas9	negative selection	11593677
136174481	136174504	5	-	28162770	HEL	viability	GGGAATCTTACAGACAGTGGTGG	SMAD5	ENSG00000113658	-1.2927209158049324	[305]	[79]	-6	hSpCas9	negative selection	11763034
136172449	136172472	5	+	28162770	HEL	viability	CCTATGAAGAGCCTAAACATTGG	SMAD5	ENSG00000113658	0.004176941895145281	[424]	[272]	0	hSpCas9	negative selection	11763035
136163361	136163384	5	-	28162770	HEL	viability	GATATACTGGGCATAATCTGAGG	SMAD5	ENSG00000113658	0.680873960887128	[223]	[229]	6	hSpCas9	negative selection	11763036
136163280	136163303	5	-	28162770	HEL	viability	GGTGGCATATAGGCAGGAGGAGG	SMAD5	ENSG00000113658	0.47641606723824004	[449]	[400]	4	hSpCas9	negative selection	11763037
136153817	136153840	5	+	28162770	HEL	viability	GGGCTGGAAACAAGGTGATGAGG	SMAD5	ENSG00000113658	-0.15058920478496163	[434]	[250]	-1	hSpCas9	negative selection	11763038
136160861	136160884	5	-	28162770	HEL	viability	TGACGAGGCACTAATACTGGAGG	SMAD5	ENSG00000113658	-0.7933602828063164	[137]	[50]	-5	hSpCas9	negative selection	11763039
136160908	136160931	5	-	28162770	HEL	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-1.3937870440247573	[159]	[38]	-7	hSpCas9	negative selection	11763040
136161033	136161056	5	-	28162770	HEL	viability	TGTGCTGCTAGCAGGAGAAGGGG	SMAD5	ENSG00000113658	-0.4261230261444472	[471]	[224]	-3	hSpCas9	negative selection	11763041
136174569	136174592	5	-	28162770	HEL	viability	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	1.8651312533368047	[95]	[223]	9	hSpCas9	negative selection	11763042
136153828	136153851	5	+	28162770	HEL	viability	AAGGTGATGAGGAGGAGAAATGG	SMAD5	ENSG00000113658	-0.5049047220659488	[256]	[115]	-3	hSpCas9	negative selection	11763043
136174481	136174504	5	-	28162770	MV411	viability	GGGAATCTTACAGACAGTGGTGG	SMAD5	ENSG00000113658	0.309721829037118	[271]	[283]	2	hSpCas9	negative selection	11932400
136172449	136172472	5	+	28162770	MV411	viability	CCTATGAAGAGCCTAAACATTGG	SMAD5	ENSG00000113658	1.010474123290556	[339]	[576]	8	hSpCas9	negative selection	11932401
136163361	136163384	5	-	28162770	MV411	viability	GATATACTGGGCATAATCTGAGG	SMAD5	ENSG00000113658	0.42038390420032473	[211]	[238]	4	hSpCas9	negative selection	11932402
136163280	136163303	5	-	28162770	MV411	viability	GGTGGCATATAGGCAGGAGGAGG	SMAD5	ENSG00000113658	0.8592001108476467	[319]	[488]	7	hSpCas9	negative selection	11932403
136153817	136153840	5	+	28162770	MV411	viability	GGGCTGGAAACAAGGTGATGAGG	SMAD5	ENSG00000113658	0.5185413865924553	[415]	[501]	4	hSpCas9	negative selection	11932404
136160861	136160884	5	-	28162770	MV411	viability	TGACGAGGCACTAATACTGGAGG	SMAD5	ENSG00000113658	-0.02265161258496884	[122]	[101]	0	hSpCas9	negative selection	11932405
136160908	136160931	5	-	28162770	MV411	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.1890208645574532	[125]	[120]	1	hSpCas9	negative selection	11932406
136161033	136161056	5	-	28162770	MV411	viability	TGTGCTGCTAGCAGGAGAAGGGG	SMAD5	ENSG00000113658	-0.5395015347207346	[420]	[243]	-4	hSpCas9	negative selection	11932407
136174569	136174592	5	-	28162770	MV411	viability	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	0.6762808495866497	[103]	[139]	6	hSpCas9	negative selection	11932408
136153828	136153851	5	+	28162770	MV411	viability	AAGGTGATGAGGAGGAGAAATGG	SMAD5	ENSG00000113658	-0.04206906641220945	[219]	[179]	0	hSpCas9	negative selection	11932409
136174481	136174504	5	-	28162770	MONOMAC1	viability	GGGAATCTTACAGACAGTGGTGG	SMAD5	ENSG00000113658	0.05572922332041297	[187]	[223]	0	hSpCas9	negative selection	12101766
136172449	136172472	5	+	28162770	MONOMAC1	viability	CCTATGAAGAGCCTAAACATTGG	SMAD5	ENSG00000113658	0.5892564594702208	[275]	[475]	6	hSpCas9	negative selection	12101767
136163361	136163384	5	-	28162770	MONOMAC1	viability	GATATACTGGGCATAATCTGAGG	SMAD5	ENSG00000113658	0.1794054069067122	[160]	[208]	1	hSpCas9	negative selection	12101768
136163280	136163303	5	-	28162770	MONOMAC1	viability	GGTGGCATATAGGCAGGAGGAGG	SMAD5	ENSG00000113658	0.09935615572067102	[227]	[279]	1	hSpCas9	negative selection	12101769
136153817	136153840	5	+	28162770	MONOMAC1	viability	GGGCTGGAAACAAGGTGATGAGG	SMAD5	ENSG00000113658	-0.17122766070994833	[276]	[281]	-1	hSpCas9	negative selection	12101770
136160861	136160884	5	-	28162770	MONOMAC1	viability	TGACGAGGCACTAATACTGGAGG	SMAD5	ENSG00000113658	0.03091509961879481	[110]	[129]	0	hSpCas9	negative selection	12101771
136160908	136160931	5	-	28162770	MONOMAC1	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.1970368470595536	[61]	[61]	-2	hSpCas9	negative selection	12101772
136161033	136161056	5	-	28162770	MONOMAC1	viability	TGTGCTGCTAGCAGGAGAAGGGG	SMAD5	ENSG00000113658	-0.2791858884134252	[270]	[255]	-2	hSpCas9	negative selection	12101773
136174569	136174592	5	-	28162770	MONOMAC1	viability	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	0.46592816566287565	[59]	[94]	4	hSpCas9	negative selection	12101774
136153828	136153851	5	+	28162770	MONOMAC1	viability	AAGGTGATGAGGAGGAGAAATGG	SMAD5	ENSG00000113658	-0.0745528405345588	[157]	[171]	0	hSpCas9	negative selection	12101775
136174481	136174504	5	-	28162770	OCIAML2	viability	GGGAATCTTACAGACAGTGGTGG	SMAD5	ENSG00000113658	-0.6786228675179932	[53]	[186]	-5	hSpCas9	negative selection	12271132
136172449	136172472	5	+	28162770	OCIAML2	viability	CCTATGAAGAGCCTAAACATTGG	SMAD5	ENSG00000113658	0.11673516569429965	[99]	[600]	1	hSpCas9	negative selection	12271133
136163361	136163384	5	-	28162770	OCIAML2	viability	GATATACTGGGCATAATCTGAGG	SMAD5	ENSG00000113658	0.4236607335867237	[45]	[341]	4	hSpCas9	negative selection	12271134
136163280	136163303	5	-	28162770	OCIAML2	viability	GGTGGCATATAGGCAGGAGGAGG	SMAD5	ENSG00000113658	0.16495874854896297	[69]	[434]	1	hSpCas9	negative selection	12271135
136153817	136153840	5	+	28162770	OCIAML2	viability	GGGCTGGAAACAAGGTGATGAGG	SMAD5	ENSG00000113658	0.21427411335290159	[78]	[507]	2	hSpCas9	negative selection	12271136
136160861	136160884	5	-	28162770	OCIAML2	viability	TGACGAGGCACTAATACTGGAGG	SMAD5	ENSG00000113658	0.09821301011571815	[14]	[88]	0	hSpCas9	negative selection	12271137
136160908	136160931	5	-	28162770	OCIAML2	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	0.4727866463914711	[25]	[199]	4	hSpCas9	negative selection	12271138
136161033	136161056	5	-	28162770	OCIAML2	viability	TGTGCTGCTAGCAGGAGAAGGGG	SMAD5	ENSG00000113658	0.32648591231060475	[100]	[701]	3	hSpCas9	negative selection	12271139
136174569	136174592	5	-	28162770	OCIAML2	viability	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	-1.3581550959837487	[36]	[79]	-7	hSpCas9	negative selection	12271140
136153828	136153851	5	+	28162770	OCIAML2	viability	AAGGTGATGAGGAGGAGAAATGG	SMAD5	ENSG00000113658	0.14336172409052705	[40]	[250]	1	hSpCas9	negative selection	12271141
136174481	136174504	5	-	28162770	OCIAML3	viability	GGGAATCTTACAGACAGTGGTGG	SMAD5	ENSG00000113658	-1.2332602965462727	[87]	[112]	-7	hSpCas9	negative selection	12440498
136172449	136172472	5	+	28162770	OCIAML3	viability	CCTATGAAGAGCCTAAACATTGG	SMAD5	ENSG00000113658	-0.37558412119066087	[103]	[241]	-3	hSpCas9	negative selection	12440499
136163361	136163384	5	-	28162770	OCIAML3	viability	GATATACTGGGCATAATCTGAGG	SMAD5	ENSG00000113658	1.098483324701438	[55]	[361]	8	hSpCas9	negative selection	12440500
136163280	136163303	5	-	28162770	OCIAML3	viability	GGTGGCATATAGGCAGGAGGAGG	SMAD5	ENSG00000113658	0.7308617298753218	[97]	[490]	6	hSpCas9	negative selection	12440501
136153817	136153840	5	+	28162770	OCIAML3	viability	GGGCTGGAAACAAGGTGATGAGG	SMAD5	ENSG00000113658	1.2025540016594383	[114]	[798]	8	hSpCas9	negative selection	12440502
136160861	136160884	5	-	28162770	OCIAML3	viability	TGACGAGGCACTAATACTGGAGG	SMAD5	ENSG00000113658	-1.1345760216868659	[23]	[32]	-7	hSpCas9	negative selection	12440503
136160908	136160931	5	-	28162770	OCIAML3	viability	GGTTCCTAAACTGAACCAGAAGG	SMAD5	ENSG00000113658	-0.9159357352115256	[29]	[47]	-6	hSpCas9	negative selection	12440504
136161033	136161056	5	-	28162770	OCIAML3	viability	TGTGCTGCTAGCAGGAGAAGGGG	SMAD5	ENSG00000113658	-0.7070166021533494	[145]	[269]	-5	hSpCas9	negative selection	12440505
136174569	136174592	5	-	28162770	OCIAML3	viability	CATATACTGCCTCAAACCCATGG	SMAD5	ENSG00000113658	-0.594007640324163	[31]	[63]	-4	hSpCas9	negative selection	12440506
136153828	136153851	5	+	28162770	OCIAML3	viability	AAGGTGATGAGGAGGAGAAATGG	SMAD5	ENSG00000113658	-0.21549601707043334	[59]	[155]	-2	hSpCas9	negative selection	12440507