Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:4091
• Symbol:SMAD6
• Description:SMAD family member 6

DataSource: http://genomecrispr.dkfz.de/#!/results/SMAD6

Export (tab separated) Export to Excel

Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
66711679	66711702	15	-	26472758	Jiyoye	viability	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	0.020152258396626044	[33]	[25]	0	hSpCas9	negative selection	151589
66781053	66781076	15	+	26472758	Jiyoye	viability	TGGGAGCACCGGACGCGCGTGGG	SMAD6	ENSG00000137834	0.8352690336101637	[54]	[73]	6	hSpCas9	negative selection	151590
66716437	66716460	15	+	26472758	Jiyoye	viability	ATTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	2.531503516508075	[24]	[108]	9	hSpCas9	negative selection	151591
66716463	66716486	15	-	26472758	Jiyoye	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	1.4637589098722408	[74]	[155]	8	hSpCas9	negative selection	151592
66711700	66711723	15	-	26472758	Jiyoye	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.13924217625924062	[235]	[195]	1	hSpCas9	negative selection	151593
66716477	66716500	15	+	26472758	Jiyoye	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	0.5028587295611814	[174]	[186]	4	hSpCas9	negative selection	151594
66781496	66781519	15	-	26472758	Jiyoye	viability	GGAGGATCTCCAGCCAGCAGGGG	SMAD6	ENSG00000137834	3.3033395705213335	[17]	[133]	9	hSpCas9	negative selection	151595
66781076	66781099	15	-	26472758	Jiyoye	viability	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	1.4590143130254916	[40]	[84]	8	hSpCas9	negative selection	151596
66781239	66781262	15	+	26472758	Jiyoye	viability	GGCGTGTGGGCCTACAACCGCGG	SMAD6	ENSG00000137834	0.685891409571937	[60]	[73]	5	hSpCas9	negative selection	151597
66781031	66781054	15	-	26472758	Jiyoye	viability	AGTACGCCACGCTGCACCAGTGG	SMAD6	ENSG00000137834	-0.019089373196224613	[85]	[63]	0	hSpCas9	negative selection	151598
66711679	66711702	15	-	26472758	KBM7	viability	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	-1.913397529790178	[247,126]	[36,9]	-8	hSpCas9	negative selection	342707
66781053	66781076	15	+	26472758	KBM7	viability	TGGGAGCACCGGACGCGCGTGGG	SMAD6	ENSG00000137834	-1.3355030786765998	[462,315]	[89,54]	-7	hSpCas9	negative selection	342708
66716437	66716460	15	+	26472758	KBM7	viability	ATTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	-0.6944759317002898	[409,248]	[87,98]	-5	hSpCas9	negative selection	342709
66716463	66716486	15	-	26472758	KBM7	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	0.013132819251115313	[706,551]	[477,133]	0	hSpCas9	negative selection	342710
66711700	66711723	15	-	26472758	KBM7	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.3120478376000715	[1226,746]	[656,481]	3	hSpCas9	negative selection	342711
66716477	66716500	15	+	26472758	KBM7	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	0.35440785808247444	[564,337]	[279,252]	4	hSpCas9	negative selection	342712
66781496	66781519	15	-	26472758	KBM7	viability	GGAGGATCTCCAGCCAGCAGGGG	SMAD6	ENSG00000137834	0.190343407036974	[389,290]	[211,152]	2	hSpCas9	negative selection	342713
66781076	66781099	15	-	26472758	KBM7	viability	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	-0.26670007360175363	[760,685]	[279,284]	-3	hSpCas9	negative selection	342714
66781239	66781262	15	+	26472758	KBM7	viability	GGCGTGTGGGCCTACAACCGCGG	SMAD6	ENSG00000137834	-1.0934004714268444	[548,267]	[62,108]	-7	hSpCas9	negative selection	342715
66781031	66781054	15	-	26472758	KBM7	viability	AGTACGCCACGCTGCACCAGTGG	SMAD6	ENSG00000137834	0.14261304534888908	[691,527]	[326,301]	1	hSpCas9	negative selection	342716
66711679	66711702	15	-	26472758	Raji	viability	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	0.785455440486237	[29]	[11]	7	hSpCas9	negative selection	533825
66781053	66781076	15	+	26472758	Raji	viability	TGGGAGCACCGGACGCGCGTGGG	SMAD6	ENSG00000137834	-0.49017900212719023	[229]	[37]	-4	hSpCas9	negative selection	533826
66716437	66716460	15	+	26472758	Raji	viability	ATTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	0.3312795473004351	[136]	[39]	3	hSpCas9	negative selection	533827
66716463	66716486	15	-	26472758	Raji	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	-0.4363563026210436	[413]	[70]	-4	hSpCas9	negative selection	533828
66711700	66711723	15	-	26472758	Raji	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.5903250991542468	[497]	[173]	5	hSpCas9	negative selection	533829
66716477	66716500	15	+	26472758	Raji	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	1.1496117707628968	[201]	[103]	8	hSpCas9	negative selection	533830
66781496	66781519	15	-	26472758	Raji	viability	GGAGGATCTCCAGCCAGCAGGGG	SMAD6	ENSG00000137834	-1.2394192281527923	[233]	[22]	-7	hSpCas9	negative selection	533831
66781076	66781099	15	-	26472758	Raji	viability	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	-0.10253953400063187	[383]	[82]	-1	hSpCas9	negative selection	533832
66781239	66781262	15	+	26472758	Raji	viability	GGCGTGTGGGCCTACAACCGCGG	SMAD6	ENSG00000137834	0.3704179412073932	[199]	[59]	3	hSpCas9	negative selection	533833
66781031	66781054	15	-	26472758	Raji	viability	AGTACGCCACGCTGCACCAGTGG	SMAD6	ENSG00000137834	0.12208004658030142	[292]	[73]	1	hSpCas9	negative selection	533834
66711679	66711702	15	-	26472758	K562	viability	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	-6.686318609896439	[121]	[0]	-9	hSpCas9	negative selection	724943
66781053	66781076	15	+	26472758	K562	viability	TGGGAGCACCGGACGCGCGTGGG	SMAD6	ENSG00000137834	0.5896859486411165	[232]	[295]	5	hSpCas9	negative selection	724944
66716437	66716460	15	+	26472758	K562	viability	ATTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	0.03796785019902049	[224]	[194]	0	hSpCas9	negative selection	724945
66716463	66716486	15	-	26472758	K562	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	0.30572928106081787	[667]	[696]	2	hSpCas9	negative selection	724946
66711700	66711723	15	-	26472758	K562	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.34553635485057566	[1032]	[1107]	2	hSpCas9	negative selection	724947
66716477	66716500	15	+	26472758	K562	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	0.6147871776115624	[409]	[529]	5	hSpCas9	negative selection	724948
66781496	66781519	15	-	26472758	K562	viability	GGAGGATCTCCAGCCAGCAGGGG	SMAD6	ENSG00000137834	0.8330475455853728	[261]	[393]	7	hSpCas9	negative selection	724949
66781076	66781099	15	-	26472758	K562	viability	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	0.07312429561263678	[526]	[467]	0	hSpCas9	negative selection	724950
66781239	66781262	15	+	26472758	K562	viability	GGCGTGTGGGCCTACAACCGCGG	SMAD6	ENSG00000137834	0.5609736504549574	[268]	[334]	4	hSpCas9	negative selection	724951
66781031	66781054	15	-	26472758	K562	viability	AGTACGCCACGCTGCACCAGTGG	SMAD6	ENSG00000137834	0.4471034775854088	[357]	[411]	3	hSpCas9	negative selection	724952
66703782	66703805	15	+	26627737	DLD1	viability	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	-0.24189191790795606	[958]	[314,231,217]	-3	hSpCas9	negative selection	791435
66703939	66703962	15	-	26627737	DLD1	viability	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	0.8242301092001691	[230]	[157,77,142]	7	hSpCas9	negative selection	791436
66711702	66711725	15	+	26627737	DLD1	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.36107247168815404	[399]	[44,125,118]	-4	hSpCas9	negative selection	791437
66711700	66711723	15	-	26627737	DLD1	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.48387785631797864	[104]	[19,26,83]	5	hSpCas9	negative selection	791438
66717040	66717063	15	-	26627737	DLD1	viability	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	-0.1938185172468403	[929]	[297,164,289]	-2	hSpCas9	negative selection	791439
66781079	66781102	15	+	26627737	DLD1	viability	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	4.732766605471652	[3]	[63,39,0]	9	hSpCas9	negative selection	791440
66703782	66703805	15	+	26627737	GBM cells	viability after 5 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	0.009497040950754876	[476]	[256,257]	0	hSpCas9	negative selection	873750
66703939	66703962	15	-	26627737	GBM cells	viability after 5 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	-0.21914188663602674	[139]	[47,80]	-3	hSpCas9	negative selection	873751
66711702	66711725	15	+	26627737	GBM cells	viability after 5 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.5275033080070997	[151]	[114,119]	7	hSpCas9	negative selection	873752
66711700	66711723	15	-	26627737	GBM cells	viability after 5 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	1.2681476845514044	[11]	[16,13]	9	hSpCas9	negative selection	873753
66717040	66717063	15	-	26627737	GBM cells	viability after 5 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	-0.07128757783599982	[574]	[322,263]	-1	hSpCas9	negative selection	873754
66781079	66781102	15	+	26627737	GBM cells	viability after 5 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	-1.200621798665229	[44]	[13,6]	-9	hSpCas9	negative selection	873755
66703782	66703805	15	+	26627737	GBM cells	viability after 13 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	0.4315840378028636	[476]	[401,305]	5	hSpCas9	negative selection	956065
66703939	66703962	15	-	26627737	GBM cells	viability after 13 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	0.05364368514578832	[139]	[101,59]	0	hSpCas9	negative selection	956066
66711702	66711725	15	+	26627737	GBM cells	viability after 13 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.8369476582026829	[151]	[159,136]	8	hSpCas9	negative selection	956067
66711700	66711723	15	-	26627737	GBM cells	viability after 13 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.8142310106859889	[11]	[11,10]	8	hSpCas9	negative selection	956068
66717040	66717063	15	-	26627737	GBM cells	viability after 13 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	0.10640241571218922	[574]	[406,277]	1	hSpCas9	negative selection	956069
66781079	66781102	15	+	26627737	GBM cells	viability after 13 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	-1.1503183541139297	[44]	[10,10]	-8	hSpCas9	negative selection	956070
66703782	66703805	15	+	26627737	GBM cells	viability after 21 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	0.7175489409296053	[476]	[469,385]	7	hSpCas9	negative selection	1038380
66703939	66703962	15	-	26627737	GBM cells	viability after 21 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	0.48415395804069894	[139]	[108,103]	5	hSpCas9	negative selection	1038381
66711702	66711725	15	+	26627737	GBM cells	viability after 21 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.7080523242329781	[151]	[148,121]	7	hSpCas9	negative selection	1038382
66711700	66711723	15	-	26627737	GBM cells	viability after 21 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	1.2720417454828459	[11]	[9,20]	9	hSpCas9	negative selection	1038383
66717040	66717063	15	-	26627737	GBM cells	viability after 21 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	-0.20527242861882922	[574]	[271,269]	-2	hSpCas9	negative selection	1038384
66781079	66781102	15	+	26627737	GBM cells	viability after 21 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	0.4342308548639533	[44]	[43,22]	4	hSpCas9	negative selection	1038385
66703782	66703805	15	+	26627737	RPE1	viability after 9 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	0.6578394391334941	[1080]	[505,569]	4	hSpCas9	negative selection	1120695
66703939	66703962	15	-	26627737	RPE1	viability after 9 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	-0.12359225204157476	[535]	[167,135]	-1	hSpCas9	negative selection	1120696
66711702	66711725	15	+	26627737	RPE1	viability after 9 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	1.3822215344637174	[289]	[161,332]	7	hSpCas9	negative selection	1120697
66711700	66711723	15	-	26627737	RPE1	viability after 9 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.9198794829970822	[365]	[91,19]	-6	hSpCas9	negative selection	1120698
66717040	66717063	15	-	26627737	RPE1	viability after 9 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	-0.908153517403123	[1922]	[315,326]	-6	hSpCas9	negative selection	1120699
66781079	66781102	15	+	26627737	RPE1	viability after 9 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	-1.9470535863249938	[135]	[0,23]	-8	hSpCas9	negative selection	1120700
66703782	66703805	15	+	26627737	RPE1	viability after 12 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	0.44773352615369094	[1080]	[450,337]	3	hSpCas9	negative selection	1203010
66703939	66703962	15	-	26627737	RPE1	viability after 12 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	0.2758056688490551	[535]	[202,143]	1	hSpCas9	negative selection	1203011
66711702	66711725	15	+	26627737	RPE1	viability after 12 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.8694286109540734	[289]	[102,183]	5	hSpCas9	negative selection	1203012
66711700	66711723	15	-	26627737	RPE1	viability after 12 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.2690911795267714	[365]	[118,41]	-2	hSpCas9	negative selection	1203013
66717040	66717063	15	-	26627737	RPE1	viability after 12 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	-0.49260938714031377	[1922]	[390,341]	-3	hSpCas9	negative selection	1203014
66781079	66781102	15	+	26627737	RPE1	viability after 12 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	-2.90278193163627	[135]	[0,8]	-9	hSpCas9	negative selection	1203015
66703782	66703805	15	+	26627737	RPE1	viability after 15 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	0.3439987457426426	[1080]	[436,340]	2	hSpCas9	negative selection	1285325
66703939	66703962	15	-	26627737	RPE1	viability after 15 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	0.16058930695575607	[535]	[198,140]	1	hSpCas9	negative selection	1285326
66711702	66711725	15	+	26627737	RPE1	viability after 15 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.9077570714791415	[289]	[130,175]	5	hSpCas9	negative selection	1285327
66711700	66711723	15	-	26627737	RPE1	viability after 15 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.3861680567764183	[365]	[94,63]	-2	hSpCas9	negative selection	1285328
66717040	66717063	15	-	26627737	RPE1	viability after 15 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	-0.38323231972530647	[1922]	[440,393]	-2	hSpCas9	negative selection	1285329
66781079	66781102	15	+	26627737	RPE1	viability after 15 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	-2.7850745264697534	[135]	[0,9]	-9	hSpCas9	negative selection	1285330
66703782	66703805	15	+	26627737	RPE1	viability after 18 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	0.6649822272706409	[1080]	[565,351]	4	hSpCas9	negative selection	1367640
66703939	66703962	15	-	26627737	RPE1	viability after 18 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	-0.8162863613843675	[535]	[100,61]	-5	hSpCas9	negative selection	1367641
66711702	66711725	15	+	26627737	RPE1	viability after 18 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.5111189126723943	[289]	[97,125]	3	hSpCas9	negative selection	1367642
66711700	66711723	15	-	26627737	RPE1	viability after 18 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.6115747429789502	[365]	[97,28]	-4	hSpCas9	negative selection	1367643
66717040	66717063	15	-	26627737	RPE1	viability after 18 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	-0.8325567148835371	[1922]	[215,371]	-5	hSpCas9	negative selection	1367644
66781079	66781102	15	+	26627737	RPE1	viability after 18 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	-5.197794581149596	[135]	[0,0]	-9	hSpCas9	negative selection	1367645
66703782	66703805	15	+	26627737	HeLa	viability after 8 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	-0.2773542850694417	[1072]	[555,380,264]	-3	hSpCas9	negative selection	1449955
66703939	66703962	15	-	26627737	HeLa	viability after 8 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	-0.8363808805377748	[339]	[85,120,44]	-7	hSpCas9	negative selection	1449956
66711702	66711725	15	+	26627737	HeLa	viability after 8 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-1.3265634785692137	[418]	[159,14,62]	-8	hSpCas9	negative selection	1449957
66711700	66711723	15	-	26627737	HeLa	viability after 8 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.8949205771815452	[273]	[307,226,153]	7	hSpCas9	negative selection	1449958
66717040	66717063	15	-	26627737	HeLa	viability after 8 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	-0.0890636710398881	[718]	[292,366,226]	-1	hSpCas9	negative selection	1449959
66781079	66781102	15	+	26627737	HeLa	viability after 8 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	5.024114781201972	[0]	[0,0,35]	9	hSpCas9	negative selection	1449960
66703782	66703805	15	+	26627737	HeLa	viability after 12 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	-0.030564091095836687	[1072]	[455,528,307]	0	hSpCas9	negative selection	1532270
66703939	66703962	15	-	26627737	HeLa	viability after 12 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	-0.8624410899004127	[339]	[133,81,16]	-7	hSpCas9	negative selection	1532271
66711702	66711725	15	+	26627737	HeLa	viability after 12 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-1.3584360195025853	[418]	[52,21,131]	-8	hSpCas9	negative selection	1532272
66711700	66711723	15	-	26627737	HeLa	viability after 12 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.023534695880883305	[273]	[20,97,213]	0	hSpCas9	negative selection	1532273
66717040	66717063	15	-	26627737	HeLa	viability after 12 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	-0.3685159763370182	[718]	[219,127,352]	-3	hSpCas9	negative selection	1532274
66781079	66781102	15	+	26627737	HeLa	viability after 12 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	6.128911229238631	[0]	[63,7,17]	9	hSpCas9	negative selection	1532275
66703782	66703805	15	+	26627737	HeLa	viability after 15 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	0.21470346307281618	[1072]	[539,585,384]	1	hSpCas9	negative selection	1614585
66703939	66703962	15	-	26627737	HeLa	viability after 15 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	-0.8099246324240554	[339]	[165,47,16]	-6	hSpCas9	negative selection	1614586
66711702	66711725	15	+	26627737	HeLa	viability after 15 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-1.0709206099784272	[418]	[4,116,125]	-7	hSpCas9	negative selection	1614587
66711700	66711723	15	-	26627737	HeLa	viability after 15 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.35697784395191934	[273]	[75,215,136]	3	hSpCas9	negative selection	1614588
66717040	66717063	15	-	26627737	HeLa	viability after 15 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	-0.21123135732151666	[718]	[104,129,547]	-2	hSpCas9	negative selection	1614589
66781079	66781102	15	+	26627737	HeLa	viability after 15 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	6.448624769127638	[0]	[0,71,33]	9	hSpCas9	negative selection	1614590
66703782	66703805	15	+	26627737	HeLa	viability after 18 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	0.232876352606723	[1072]	[366,494,384]	2	hSpCas9	negative selection	1696900
66703939	66703962	15	-	26627737	HeLa	viability after 18 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	-0.8003448265060888	[339]	[112,38,16]	-6	hSpCas9	negative selection	1696901
66711702	66711725	15	+	26627737	HeLa	viability after 18 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-1.035354919653465	[418]	[3,100,125]	-7	hSpCas9	negative selection	1696902
66711700	66711723	15	-	26627737	HeLa	viability after 18 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.32720312735843954	[273]	[45,177,136]	2	hSpCas9	negative selection	1696903
66717040	66717063	15	-	26627737	HeLa	viability after 18 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	-0.1746393020876844	[718]	[77,113,547]	-1	hSpCas9	negative selection	1696904
66781079	66781102	15	+	26627737	HeLa	viability after 18 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	6.557753325962002	[0]	[0,65,33]	9	hSpCas9	negative selection	1696905
66703782	66703805	15	+	26627737	HCT116	viability after 6 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	2.1202728531172164	[1290]	[2117,200]	8	hSpCas9	negative selection	1779215
66703939	66703962	15	-	26627737	HCT116	viability after 6 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	-0.0979893186509963	[536]	[16,112]	0	hSpCas9	negative selection	1779216
66711702	66711725	15	+	26627737	HCT116	viability after 6 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.4148414062724919	[563]	[94,130]	2	hSpCas9	negative selection	1779217
66711700	66711723	15	-	26627737	HCT116	viability after 6 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.11909479645694465	[277]	[60,39]	0	hSpCas9	negative selection	1779218
66717040	66717063	15	-	26627737	HCT116	viability after 6 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	-0.1212022389071295	[939]	[267,62]	0	hSpCas9	negative selection	1779219
66781079	66781102	15	+	26627737	HCT116	viability after 6 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	1.425570428046735	[115]	[135,0]	7	hSpCas9	negative selection	1779220
66703782	66703805	15	+	26627737	HCT116	viability after 8 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	-0.30833136547622253	[797]	[307,361,393]	-4	hSpCas9	negative selection	1861530
66703939	66703962	15	-	26627737	HCT116	viability after 8 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	-0.6529386098446148	[332]	[110,122,115]	-7	hSpCas9	negative selection	1861531
66711702	66711725	15	+	26627737	HCT116	viability after 8 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.02734978475671268	[241]	[152,114,124]	0	hSpCas9	negative selection	1861532
66711700	66711723	15	-	26627737	HCT116	viability after 8 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.09267292451492581	[182]	[130,112,40]	-1	hSpCas9	negative selection	1861533
66717040	66717063	15	-	26627737	HCT116	viability after 8 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	-0.010166585287289642	[577]	[318,245,382]	0	hSpCas9	negative selection	1861534
66781079	66781102	15	+	26627737	HCT116	viability after 8 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	1.1807665507414598	[21]	[4,45,30]	8	hSpCas9	negative selection	1861535
66703782	66703805	15	+	26627737	HCT116	viability after 9 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	0.8024782565853976	[1290]	[765,470]	5	hSpCas9	negative selection	1943845
66703939	66703962	15	-	26627737	HCT116	viability after 9 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	-1.6091996149543066	[536]	[46,46]	-8	hSpCas9	negative selection	1943846
66711702	66711725	15	+	26627737	HCT116	viability after 9 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.5797971902278191	[563]	[290,172]	4	hSpCas9	negative selection	1943847
66711700	66711723	15	-	26627737	HCT116	viability after 9 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.8813400847155464	[277]	[46,34]	-6	hSpCas9	negative selection	1943848
66717040	66717063	15	-	26627737	HCT116	viability after 9 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	-0.6897119479903526	[939]	[206,114]	-5	hSpCas9	negative selection	1943849
66781079	66781102	15	+	26627737	HCT116	viability after 9 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	1.1196785964926272	[115]	[30,95]	7	hSpCas9	negative selection	1943850
66703782	66703805	15	+	26627737	HCT116	viability after 12 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	-0.5612344937329926	[797]	[235,288,331]	-6	hSpCas9	negative selection	2026160
66703939	66703962	15	-	26627737	HCT116	viability after 12 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	-0.9620912325658708	[332]	[95,91,80]	-8	hSpCas9	negative selection	2026161
66711702	66711725	15	+	26627737	HCT116	viability after 12 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.05906286279794537	[241]	[104,136,157]	0	hSpCas9	negative selection	2026162
66711700	66711723	15	-	26627737	HCT116	viability after 12 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.6968294743189484	[182]	[113,182,174]	6	hSpCas9	negative selection	2026163
66717040	66717063	15	-	26627737	HCT116	viability after 12 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	0.09970092131171993	[577]	[429,189,343]	1	hSpCas9	negative selection	2026164
66781079	66781102	15	+	26627737	HCT116	viability after 12 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	0.9977533717116489	[21]	[12,16,39]	8	hSpCas9	negative selection	2026165
66703782	66703805	15	+	26627737	HCT116	viability after 15 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	-0.24434948197590467	[797]	[414,355,392]	-3	hSpCas9	negative selection	2108475
66703939	66703962	15	-	26627737	HCT116	viability after 15 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	-1.0682356197130993	[332]	[93,92,86]	-8	hSpCas9	negative selection	2108476
66711702	66711725	15	+	26627737	HCT116	viability after 15 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.29364066338475253	[241]	[171,120,54]	-3	hSpCas9	negative selection	2108477
66711700	66711723	15	-	26627737	HCT116	viability after 15 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.3081357497232735	[182]	[197,184,16]	3	hSpCas9	negative selection	2108478
66717040	66717063	15	-	26627737	HCT116	viability after 15 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	0.17169755925875774	[577]	[417,247,459]	1	hSpCas9	negative selection	2108479
66781079	66781102	15	+	26627737	HCT116	viability after 15 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	0.7051209858440592	[21]	[4,42,11]	6	hSpCas9	negative selection	2108480
66703782	66703805	15	+	26627737	HCT116	viability after 18 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	-0.4103717462947829	[797]	[305,273,291]	-4	hSpCas9	negative selection	2190790
66703939	66703962	15	-	26627737	HCT116	viability after 18 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	-0.453456330451019	[332]	[100,138,110]	-4	hSpCas9	negative selection	2190791
66711702	66711725	15	+	26627737	HCT116	viability after 18 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.8024681680212511	[241]	[100,20,82]	-6	hSpCas9	negative selection	2190792
66711700	66711723	15	-	26627737	HCT116	viability after 18 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.25416568666701994	[182]	[105,109,99]	2	hSpCas9	negative selection	2190793
66717040	66717063	15	-	26627737	HCT116	viability after 18 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	0.30183069418968156	[577]	[425,202,416]	2	hSpCas9	negative selection	2190794
66781079	66781102	15	+	26627737	HCT116	viability after 18 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	1.911623071591468	[21]	[23,46,48]	9	hSpCas9	negative selection	2190795
66711664	66711687	15	-	24336569	HL60	viability	TAGGGAGGTGGCGGAGATTCTGG	SMAD6	ENSG00000137834	0.7020326485199277	[600]	[2068]	6	hSpCas9	negative selection	2295683
66711671	66711694	15	+	24336569	HL60	viability	CTCCGCCACCTCCCTACTCTCGG	SMAD6	ENSG00000137834	-1.3028046115717578	[456]	[391]	-8	hSpCas9	negative selection	2295684
66711676	66711699	15	-	24336569	HL60	viability	GACAGCCGAGAGTAGGGAGGTGG	SMAD6	ENSG00000137834	-0.3965435299137882	[682]	[1097]	-4	hSpCas9	negative selection	2295685
66711682	66711705	15	-	24336569	HL60	viability	CGAGGAGACAGCCGAGAGTAGGG	SMAD6	ENSG00000137834	0.8793653020904255	[55]	[217]	7	hSpCas9	negative selection	2295686
66711700	66711723	15	-	24336569	HL60	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.13528680013504313	[709]	[1367]	-1	hSpCas9	negative selection	2295687
66716427	66716450	15	-	24336569	HL60	viability	AGTGTAAGACAATGTGGAATCGG	SMAD6	ENSG00000137834	-0.6560314299876739	[1935]	[2599]	-5	hSpCas9	negative selection	2295688
66716433	66716456	15	-	24336569	HL60	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	-0.49906184022630384	[1503]	[2251]	-4	hSpCas9	negative selection	2295689
66716463	66716486	15	-	24336569	HL60	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	-0.4791875460584629	[634]	[963]	-4	hSpCas9	negative selection	2295690
66716469	66716492	15	-	24336569	HL60	viability	TTCACCCGGAGCAGTGATGAGGG	SMAD6	ENSG00000137834	2.1889532687235853	[133]	[1292]	9	hSpCas9	negative selection	2295691
66716477	66716500	15	+	24336569	HL60	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	1.0066885302788051	[122]	[522]	7	hSpCas9	negative selection	2295692
66711664	66711687	15	-	24336569	KBM7	viability	TAGGGAGGTGGCGGAGATTCTGG	SMAD6	ENSG00000137834	-0.6230286592287569	[833]	[1476]	-5	hSpCas9	negative selection	2362860
66711671	66711694	15	+	24336569	KBM7	viability	CTCCGCCACCTCCCTACTCTCGG	SMAD6	ENSG00000137834	-0.060097419790600126	[184]	[483]	0	hSpCas9	negative selection	2362861
66711676	66711699	15	-	24336569	KBM7	viability	GACAGCCGAGAGTAGGGAGGTGG	SMAD6	ENSG00000137834	-0.9175556100815314	[677]	[978]	-6	hSpCas9	negative selection	2362862
66711682	66711705	15	-	24336569	KBM7	viability	CGAGGAGACAGCCGAGAGTAGGG	SMAD6	ENSG00000137834	0.5254537558508483	[80]	[317]	5	hSpCas9	negative selection	2362863
66711700	66711723	15	-	24336569	KBM7	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.2693865791229696	[695]	[1574]	-2	hSpCas9	negative selection	2362864
66716427	66716450	15	-	24336569	KBM7	viability	AGTGTAAGACAATGTGGAATCGG	SMAD6	ENSG00000137834	-0.3213444683350044	[1109]	[2422]	-3	hSpCas9	negative selection	2362865
66716433	66716456	15	-	24336569	KBM7	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	-0.40583585395012967	[1072]	[2208]	-3	hSpCas9	negative selection	2362866
66716463	66716486	15	-	24336569	KBM7	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	0.42771977185944543	[473]	[1738]	4	hSpCas9	negative selection	2362867
66716469	66716492	15	-	24336569	KBM7	viability	TTCACCCGGAGCAGTGATGAGGG	SMAD6	ENSG00000137834	-1.9070108151861798	[593]	[431]	-8	hSpCas9	negative selection	2362868
66716477	66716500	15	+	24336569	KBM7	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	-1.1603855177906093	[226]	[276]	-7	hSpCas9	negative selection	2362869
66708438	66708461	15	-	25494202	A375	resistance to PLX-4720 (puromycin)	AATCAGCCGCCACTCCCACATGG	SMAD6	ENSG00000137834	-0.5066589861774695	[234,70]	[38,4]	-2	dCas9-VP64	positive selection	2401073
66708465	66708488	15	-	25494202	A375	resistance to PLX-4720 (puromycin)	AATGTGCTATCAACACTACTGGG	SMAD6	ENSG00000137834	1.9348464585824368	[2263,171]	[1911,40]	6	dCas9-VP64	positive selection	2401074
66708419	66708442	15	-	25494202	A375	resistance to PLX-4720 (puromycin)	ATGGCTGCGCCCTGTGGATCTGG	SMAD6	ENSG00000137834	5.19331574794315	[40,52]	[16,779]	9	dCas9-VP64	positive selection	2401075
66777554	66777577	15	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGAGGATTGCTTGAGCTCAAG	SMAD6	ENSG00000137834	-0.7307069701167457	[14,47]	[6,0]	-4	dCas9-VP64	positive selection	2424942
66732063	66732086	15	-	25494202	A375	resistance to PLX-4720 (puromycin)	TGCAGTCCCAGCTACTCGAGAGG	SMAD6	ENSG00000137834	2.0561573313236643	[12,5]	[6,9]	7	dCas9-VP64	positive selection	2426754
66749065	66749088	15	+	25494202	A375	resistance to PLX-4720 (puromycin)	TGTAATCTCAGCACTTTGGGGAG	SMAD6	ENSG00000137834	0.15607651136927458	[32,6]	[6,1]	0	dCas9-VP64	positive selection	2438150
66702226	66702249	15	+	25494202	A375	resistance to PLX-4720 (puromycin)	CTAGACTGGCATATGATGGGAGG	SMAD6	ENSG00000137834	1.136157441625004	[2,42]	[11,9]	4	dCas9-VP64	positive selection	2438316
66708438	66708461	15	-	25494202	A375	resistance to PLX-4720 (zeocin)	AATCAGCCGCCACTCCCACATGG	SMAD6	ENSG00000137834	-0.4935455895391587	[336,242]	[83,51]	-5	dCas9-VP64	positive selection	2496328
66708465	66708488	15	-	25494202	A375	resistance to PLX-4720 (zeocin)	AATGTGCTATCAACACTACTGGG	SMAD6	ENSG00000137834	0.30593399863300164	[413,164]	[113,121]	2	dCas9-VP64	positive selection	2496329
66708419	66708442	15	-	25494202	A375	resistance to PLX-4720 (zeocin)	ATGGCTGCGCCCTGTGGATCTGG	SMAD6	ENSG00000137834	-0.27994433265711904	[147,31]	[29,17]	-3	dCas9-VP64	positive selection	2496330
66777554	66777577	15	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGAGGATTGCTTGAGCTCAAG	SMAD6	ENSG00000137834	-0.11990712036238094	[57,84]	[32,8]	-1	dCas9-VP64	positive selection	2520197
66732063	66732086	15	-	25494202	A375	resistance to PLX-4720 (zeocin)	TGCAGTCCCAGCTACTCGAGAGG	SMAD6	ENSG00000137834	0.16363814477086425	[202,87]	[78,28]	1	dCas9-VP64	positive selection	2522009
66749065	66749088	15	+	25494202	A375	resistance to PLX-4720 (zeocin)	TGTAATCTCAGCACTTTGGGGAG	SMAD6	ENSG00000137834	-0.09854114350347812	[128,153]	[28,55]	-1	dCas9-VP64	positive selection	2533405
66702226	66702249	15	+	25494202	A375	resistance to PLX-4720 (zeocin)	CTAGACTGGCATATGATGGGAGG	SMAD6	ENSG00000137834	2.073854704473755	[139,119]	[28,320]	8	dCas9-VP64	positive selection	2533571
66711676	66711699	15	-	27260157	DLD1	viability	GACAGCCGAGAGTAGGGAGGTGG	SMAD6	ENSG00000137834	-1.08418047484985	[]	[]	-7	hSpCas9	negative selection	2574613
66703258	66703281	15	+	27260157	DLD1	viability	TATGTTCAGGTCCAAACGCTCGG	SMAD6	ENSG00000137834	-0.602964551945407	[]	[]	-5	hSpCas9	negative selection	2577567
66716469	66716492	15	-	27260157	DLD1	viability	TTCACCCGGAGCAGTGATGAGGG	SMAD6	ENSG00000137834	-0.00560526220511142	[]	[]	0	hSpCas9	negative selection	2579004
66703291	66703314	15	+	27260157	DLD1	viability	GCGACTTTGGCGAAGTCGTGTGG	SMAD6	ENSG00000137834	-0.126162152811841	[]	[]	-1	hSpCas9	negative selection	2581288
66711682	66711705	15	-	27260157	DLD1	viability	CGAGGAGACAGCCGAGAGTAGGG	SMAD6	ENSG00000137834	0.38995261626817	[]	[]	4	hSpCas9	negative selection	2581516
66711664	66711687	15	-	27260157	DLD1	viability	TAGGGAGGTGGCGGAGATTCTGG	SMAD6	ENSG00000137834	-0.652425091980578	[]	[]	-5	hSpCas9	negative selection	2586864
66703728	66703751	15	+	27260157	DLD1	viability	GGAGTCGCGAAGCGCGCTCGCGG	SMAD6	ENSG00000137834	-1.49586559195599	[]	[]	-8	hSpCas9	negative selection	2605346
66716433	66716456	15	-	27260157	DLD1	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	-0.24206002404776	[]	[]	-2	hSpCas9	negative selection	2607380
66711671	66711694	15	+	27260157	DLD1	viability	CTCCGCCACCTCCCTACTCTCGG	SMAD6	ENSG00000137834	-0.625882176351179	[]	[]	-5	hSpCas9	negative selection	2609653
66703566	66703589	15	-	27260157	DLD1	viability	CGGCTCCGCCACGTCCAGCAGGG	SMAD6	ENSG00000137834	-0.388372560888993	[]	[]	-3	hSpCas9	negative selection	2609888
66703463	66703486	15	+	27260157	DLD1	viability	CGGGACGCAGTGGGACAGCGAGG	SMAD6	ENSG00000137834	0.858709599844701	[]	[]	9	hSpCas9	negative selection	2612325
66716463	66716486	15	-	27260157	DLD1	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	-0.124477916314525	[]	[]	-1	hSpCas9	negative selection	2612512
66716477	66716500	15	+	27260157	DLD1	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	-0.0512342231511266	[]	[]	0	hSpCas9	negative selection	2617099
66703426	66703449	15	-	27260157	DLD1	viability	CTACCGGGCGGACTTCGGAGCGG	SMAD6	ENSG00000137834	-0.488641610615022	[]	[]	-4	hSpCas9	negative selection	2618449
66703607	66703630	15	-	27260157	DLD1	viability	ACCGTCTCGCAGTCACTCTCGGG	SMAD6	ENSG00000137834	-0.000494447675516539	[]	[]	0	hSpCas9	negative selection	2620687
66716427	66716450	15	-	27260157	DLD1	viability	AGTGTAAGACAATGTGGAATCGG	SMAD6	ENSG00000137834	-0.563954895318464	[]	[]	-4	hSpCas9	negative selection	2641091
66703526	66703549	15	+	27260157	DLD1	viability	CCGAGGCCCATGTCGGAGCCAGG	SMAD6	ENSG00000137834	-0.426707823216808	[]	[]	-3	hSpCas9	negative selection	2641136
66711700	66711723	15	-	27260157	DLD1	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.59645677340791	[]	[]	-5	hSpCas9	negative selection	2643560
66711676	66711699	15	-	27260157	HT1080	viability	GACAGCCGAGAGTAGGGAGGTGG	SMAD6	ENSG00000137834	-0.282156404469802	[]	[]	-7	hSpCas9	negative selection	2650743
66703258	66703281	15	+	27260157	HT1080	viability	TATGTTCAGGTCCAAACGCTCGG	SMAD6	ENSG00000137834	-0.760097278422654	[]	[]	-8	hSpCas9	negative selection	2653697
66716469	66716492	15	-	27260157	HT1080	viability	TTCACCCGGAGCAGTGATGAGGG	SMAD6	ENSG00000137834	0.4281897812725	[]	[]	4	hSpCas9	negative selection	2655134
66703291	66703314	15	+	27260157	HT1080	viability	GCGACTTTGGCGAAGTCGTGTGG	SMAD6	ENSG00000137834	-0.752226567455668	[]	[]	-8	hSpCas9	negative selection	2657418
66711682	66711705	15	-	27260157	HT1080	viability	CGAGGAGACAGCCGAGAGTAGGG	SMAD6	ENSG00000137834	0.846699620663092	[]	[]	7	hSpCas9	negative selection	2657646
66711664	66711687	15	-	27260157	HT1080	viability	TAGGGAGGTGGCGGAGATTCTGG	SMAD6	ENSG00000137834	-0.645433653396224	[]	[]	-8	hSpCas9	negative selection	2662994
66703728	66703751	15	+	27260157	HT1080	viability	GGAGTCGCGAAGCGCGCTCGCGG	SMAD6	ENSG00000137834	-1.36584813901633	[]	[]	-9	hSpCas9	negative selection	2681476
66716433	66716456	15	-	27260157	HT1080	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	-0.638996581389959	[]	[]	-8	hSpCas9	negative selection	2683510
66711671	66711694	15	+	27260157	HT1080	viability	CTCCGCCACCTCCCTACTCTCGG	SMAD6	ENSG00000137834	-0.246415266308097	[]	[]	0	hSpCas9	negative selection	2685783
66703566	66703589	15	-	27260157	HT1080	viability	CGGCTCCGCCACGTCCAGCAGGG	SMAD6	ENSG00000137834	0.241964142408242	[]	[]	2	hSpCas9	negative selection	2686018
66703463	66703486	15	+	27260157	HT1080	viability	CGGGACGCAGTGGGACAGCGAGG	SMAD6	ENSG00000137834	0.655454868972177	[]	[]	6	hSpCas9	negative selection	2688455
66716463	66716486	15	-	27260157	HT1080	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	-0.301879069439804	[]	[]	-7	hSpCas9	negative selection	2688642
66716477	66716500	15	+	27260157	HT1080	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	-0.447937641420836	[]	[]	-7	hSpCas9	negative selection	2693229
66703426	66703449	15	-	27260157	HT1080	viability	CTACCGGGCGGACTTCGGAGCGG	SMAD6	ENSG00000137834	-0.372922690996133	[]	[]	-7	hSpCas9	negative selection	2694579
66703607	66703630	15	-	27260157	HT1080	viability	ACCGTCTCGCAGTCACTCTCGGG	SMAD6	ENSG00000137834	-0.355826122690968	[]	[]	-7	hSpCas9	negative selection	2696817
66716427	66716450	15	-	27260157	HT1080	viability	AGTGTAAGACAATGTGGAATCGG	SMAD6	ENSG00000137834	0.621749259962053	[]	[]	5	hSpCas9	negative selection	2717221
66703526	66703549	15	+	27260157	HT1080	viability	CCGAGGCCCATGTCGGAGCCAGG	SMAD6	ENSG00000137834	0.0648227801253578	[]	[]	0	hSpCas9	negative selection	2717266
66711700	66711723	15	-	27260157	HT1080	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-1.58133111325292	[]	[]	-9	hSpCas9	negative selection	2719690
66711676	66711699	15	-	27260157	MKN45	viability	GACAGCCGAGAGTAGGGAGGTGG	SMAD6	ENSG00000137834	0.118151915203037	[]	[]	4	hSpCas9	negative selection	2726873
66703258	66703281	15	+	27260157	MKN45	viability	TATGTTCAGGTCCAAACGCTCGG	SMAD6	ENSG00000137834	-0.0790616723982806	[]	[]	0	hSpCas9	negative selection	2729827
66716469	66716492	15	-	27260157	MKN45	viability	TTCACCCGGAGCAGTGATGAGGG	SMAD6	ENSG00000137834	1.15650836503306	[]	[]	8	hSpCas9	negative selection	2731264
66703291	66703314	15	+	27260157	MKN45	viability	GCGACTTTGGCGAAGTCGTGTGG	SMAD6	ENSG00000137834	1.61008648147335	[]	[]	9	hSpCas9	negative selection	2733548
66711682	66711705	15	-	27260157	MKN45	viability	CGAGGAGACAGCCGAGAGTAGGG	SMAD6	ENSG00000137834	1.23500676081549	[]	[]	9	hSpCas9	negative selection	2733776
66711664	66711687	15	-	27260157	MKN45	viability	TAGGGAGGTGGCGGAGATTCTGG	SMAD6	ENSG00000137834	-0.0905347318656414	[]	[]	0	hSpCas9	negative selection	2739124
66703728	66703751	15	+	27260157	MKN45	viability	GGAGTCGCGAAGCGCGCTCGCGG	SMAD6	ENSG00000137834	-1.93198548095163	[]	[]	-9	hSpCas9	negative selection	2757606
66716433	66716456	15	-	27260157	MKN45	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	-0.998098806009238	[]	[]	-8	hSpCas9	negative selection	2759640
66711671	66711694	15	+	27260157	MKN45	viability	CTCCGCCACCTCCCTACTCTCGG	SMAD6	ENSG00000137834	-1.20854966646898	[]	[]	-8	hSpCas9	negative selection	2761913
66703566	66703589	15	-	27260157	MKN45	viability	CGGCTCCGCCACGTCCAGCAGGG	SMAD6	ENSG00000137834	0.465737476938513	[]	[]	6	hSpCas9	negative selection	2762148
66703463	66703486	15	+	27260157	MKN45	viability	CGGGACGCAGTGGGACAGCGAGG	SMAD6	ENSG00000137834	0.971885226189966	[]	[]	8	hSpCas9	negative selection	2764585
66716463	66716486	15	-	27260157	MKN45	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	0.295456744223038	[]	[]	5	hSpCas9	negative selection	2764772
66716477	66716500	15	+	27260157	MKN45	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	-0.613747977499483	[]	[]	-6	hSpCas9	negative selection	2769359
66703426	66703449	15	-	27260157	MKN45	viability	CTACCGGGCGGACTTCGGAGCGG	SMAD6	ENSG00000137834	0.156605938685805	[]	[]	5	hSpCas9	negative selection	2770709
66703607	66703630	15	-	27260157	MKN45	viability	ACCGTCTCGCAGTCACTCTCGGG	SMAD6	ENSG00000137834	-0.604581040467959	[]	[]	-6	hSpCas9	negative selection	2772947
66716427	66716450	15	-	27260157	MKN45	viability	AGTGTAAGACAATGTGGAATCGG	SMAD6	ENSG00000137834	-0.474688087567363	[]	[]	-6	hSpCas9	negative selection	2793351
66703526	66703549	15	+	27260157	MKN45	viability	CCGAGGCCCATGTCGGAGCCAGG	SMAD6	ENSG00000137834	0.151094522237329	[]	[]	5	hSpCas9	negative selection	2793396
66711700	66711723	15	-	27260157	MKN45	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.139038653646197	[]	[]	5	hSpCas9	negative selection	2795820
66711676	66711699	15	-	27260157	RKO	viability	GACAGCCGAGAGTAGGGAGGTGG	SMAD6	ENSG00000137834	-0.0395812634538313	[]	[]	0	hSpCas9	negative selection	2803003
66703258	66703281	15	+	27260157	RKO	viability	TATGTTCAGGTCCAAACGCTCGG	SMAD6	ENSG00000137834	0.345136678520814	[]	[]	1	hSpCas9	negative selection	2805957
66716469	66716492	15	-	27260157	RKO	viability	TTCACCCGGAGCAGTGATGAGGG	SMAD6	ENSG00000137834	0.389710234140439	[]	[]	2	hSpCas9	negative selection	2807394
66703291	66703314	15	+	27260157	RKO	viability	GCGACTTTGGCGAAGTCGTGTGG	SMAD6	ENSG00000137834	0.453350995237785	[]	[]	2	hSpCas9	negative selection	2809678
66711682	66711705	15	-	27260157	RKO	viability	CGAGGAGACAGCCGAGAGTAGGG	SMAD6	ENSG00000137834	0.758394970228013	[]	[]	8	hSpCas9	negative selection	2809906
66711664	66711687	15	-	27260157	RKO	viability	TAGGGAGGTGGCGGAGATTCTGG	SMAD6	ENSG00000137834	-0.932814670567453	[]	[]	-8	hSpCas9	negative selection	2815254
66703728	66703751	15	+	27260157	RKO	viability	GGAGTCGCGAAGCGCGCTCGCGG	SMAD6	ENSG00000137834	-1.03143320992268	[]	[]	-8	hSpCas9	negative selection	2833736
66716433	66716456	15	-	27260157	RKO	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	-0.426001389662877	[]	[]	-6	hSpCas9	negative selection	2835770
66711671	66711694	15	+	27260157	RKO	viability	CTCCGCCACCTCCCTACTCTCGG	SMAD6	ENSG00000137834	-0.42761916849058	[]	[]	-6	hSpCas9	negative selection	2838043
66703566	66703589	15	-	27260157	RKO	viability	CGGCTCCGCCACGTCCAGCAGGG	SMAD6	ENSG00000137834	0.0643081048743422	[]	[]	0	hSpCas9	negative selection	2838278
66703463	66703486	15	+	27260157	RKO	viability	CGGGACGCAGTGGGACAGCGAGG	SMAD6	ENSG00000137834	0.978757167487303	[]	[]	9	hSpCas9	negative selection	2840715
66716463	66716486	15	-	27260157	RKO	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	-0.457684424682503	[]	[]	-6	hSpCas9	negative selection	2840902
66716477	66716500	15	+	27260157	RKO	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	0.664973744357232	[]	[]	3	hSpCas9	negative selection	2845489
66703426	66703449	15	-	27260157	RKO	viability	CTACCGGGCGGACTTCGGAGCGG	SMAD6	ENSG00000137834	-0.147479722724167	[]	[]	0	hSpCas9	negative selection	2846839
66703607	66703630	15	-	27260157	RKO	viability	ACCGTCTCGCAGTCACTCTCGGG	SMAD6	ENSG00000137834	-0.222197808595719	[]	[]	-1	hSpCas9	negative selection	2849077
66716427	66716450	15	-	27260157	RKO	viability	AGTGTAAGACAATGTGGAATCGG	SMAD6	ENSG00000137834	0.274118843193562	[]	[]	1	hSpCas9	negative selection	2869481
66703526	66703549	15	+	27260157	RKO	viability	CCGAGGCCCATGTCGGAGCCAGG	SMAD6	ENSG00000137834	0.532476419869376	[]	[]	3	hSpCas9	negative selection	2869526
66711700	66711723	15	-	27260157	RKO	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-1.27117409898188	[]	[]	-8	hSpCas9	negative selection	2871950
66711676	66711699	15	-	27260157	SF268	viability	GACAGCCGAGAGTAGGGAGGTGG	SMAD6	ENSG00000137834	-0.22660515821468	[]	[]	-2	hSpCas9	negative selection	2879133
66703258	66703281	15	+	27260157	SF268	viability	TATGTTCAGGTCCAAACGCTCGG	SMAD6	ENSG00000137834	-0.51440782838316	[]	[]	-4	hSpCas9	negative selection	2882087
66716469	66716492	15	-	27260157	SF268	viability	TTCACCCGGAGCAGTGATGAGGG	SMAD6	ENSG00000137834	0.335450563014879	[]	[]	4	hSpCas9	negative selection	2883524
66703291	66703314	15	+	27260157	SF268	viability	GCGACTTTGGCGAAGTCGTGTGG	SMAD6	ENSG00000137834	0.331019778097768	[]	[]	4	hSpCas9	negative selection	2885808
66711682	66711705	15	-	27260157	SF268	viability	CGAGGAGACAGCCGAGAGTAGGG	SMAD6	ENSG00000137834	0.12724640175547	[]	[]	0	hSpCas9	negative selection	2886036
66711664	66711687	15	-	27260157	SF268	viability	TAGGGAGGTGGCGGAGATTCTGG	SMAD6	ENSG00000137834	-0.048678607382673	[]	[]	0	hSpCas9	negative selection	2891384
66703728	66703751	15	+	27260157	SF268	viability	GGAGTCGCGAAGCGCGCTCGCGG	SMAD6	ENSG00000137834	0.200155546414156	[]	[]	3	hSpCas9	negative selection	2909866
66716433	66716456	15	-	27260157	SF268	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	-0.0384641902237632	[]	[]	0	hSpCas9	negative selection	2911900
66711671	66711694	15	+	27260157	SF268	viability	CTCCGCCACCTCCCTACTCTCGG	SMAD6	ENSG00000137834	-0.758723069013956	[]	[]	-6	hSpCas9	negative selection	2914173
66703566	66703589	15	-	27260157	SF268	viability	CGGCTCCGCCACGTCCAGCAGGG	SMAD6	ENSG00000137834	0.159735464311056	[]	[]	0	hSpCas9	negative selection	2914408
66703463	66703486	15	+	27260157	SF268	viability	CGGGACGCAGTGGGACAGCGAGG	SMAD6	ENSG00000137834	1.21610136317087	[]	[]	9	hSpCas9	negative selection	2916845
66716463	66716486	15	-	27260157	SF268	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	-0.973613795240809	[]	[]	-7	hSpCas9	negative selection	2917032
66716477	66716500	15	+	27260157	SF268	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	-0.142294789691577	[]	[]	-1	hSpCas9	negative selection	2921619
66703426	66703449	15	-	27260157	SF268	viability	CTACCGGGCGGACTTCGGAGCGG	SMAD6	ENSG00000137834	-0.345379782630815	[]	[]	-3	hSpCas9	negative selection	2922969
66703607	66703630	15	-	27260157	SF268	viability	ACCGTCTCGCAGTCACTCTCGGG	SMAD6	ENSG00000137834	-0.0396218637254648	[]	[]	0	hSpCas9	negative selection	2925207
66716427	66716450	15	-	27260157	SF268	viability	AGTGTAAGACAATGTGGAATCGG	SMAD6	ENSG00000137834	0.0186065341470463	[]	[]	0	hSpCas9	negative selection	2945611
66703526	66703549	15	+	27260157	SF268	viability	CCGAGGCCCATGTCGGAGCCAGG	SMAD6	ENSG00000137834	0.391134355868235	[]	[]	4	hSpCas9	negative selection	2945656
66711700	66711723	15	-	27260157	SF268	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-1.06480616893688	[]	[]	-7	hSpCas9	negative selection	2948080
66711718	66711741	15	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	AGGAGGGCACACTTACCCAGTGG	SMAD6	ENSG00000137834	-0.21078461526241143	[3,3]	[2,2]	-3	hSpCas9	positive selection	3022007
66711700	66711723	15	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.42927824668049525	[3,3]	[1,1]	-6	hSpCas9	positive selection	3022008
66711679	66711702	15	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	-0.08400322890748838	[4,3]	[4,2]	-1	hSpCas9	positive selection	3022009
66781076	66781099	15	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	0.4411388714646839	[3,2]	[5,2]	8	hSpCas9	positive selection	3022010
66711718	66711741	15	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	AGGAGGGCACACTTACCCAGTGG	SMAD6	ENSG00000137834	0.1014096379100004	[3,3]	[3,2]	1	hSpCas9	positive selection	3089865
66711700	66711723	15	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.26348019366646336	[3,3]	[3,0]	-4	hSpCas9	positive selection	3089866
66711679	66711702	15	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	0.14465155483862918	[4,4]	[3,2]	2	hSpCas9	positive selection	3089867
66781076	66781099	15	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	-0.4090951251623799	[3,3]	[3,0]	-6	hSpCas9	positive selection	3089868
66716464	66716487		+	24336571	A375	resistance to PLX after 7 days	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.0953061387713312	[31,30]	[31,33]	3	hSpCas9	positive selection	3146059
66716433	66716456		-	24336571	A375	resistance to PLX after 7 days	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.03647896578804444	[36,32]	[34,36]	1	hSpCas9	positive selection	3146060
66711702	66711725		+	24336571	A375	resistance to PLX after 7 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.055450623570169055	[41,37]	[37,43]	2	hSpCas9	positive selection	3146061
66716464	66716487		+	24336571	A375	resistance to PLX after 14 days	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	-0.49586480887312356	[34,32]	[11,9]	-6	hSpCas9	positive selection	3203852
66716433	66716456		-	24336571	A375	resistance to PLX after 14 days	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	-0.7296151953207	[56,47]	[14,13]	-8	hSpCas9	positive selection	3203853
66711702	66711725		+	24336571	A375	resistance to PLX after 14 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.09898514214906173	[39,45]	[19,17]	-1	hSpCas9	positive selection	3203854
66716464	66716487		+	24336571	A375	viability after 7 days	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	-0.37825454937063885	[42]	[31,30]	-5	hSpCas9	negative selection	3261645
66716433	66716456		-	24336571	A375	viability after 7 days	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.36604087722572864	[28]	[36,32]	5	hSpCas9	negative selection	3261646
66711702	66711725		+	24336571	A375	viability after 7 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.22856032382740588	[35]	[41,37]	3	hSpCas9	negative selection	3261647
66716464	66716487		+	24336571	A375	viability after 14 days	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	-0.23747234964889885	[42]	[34,32]	-3	hSpCas9	negative selection	3319438
66716433	66716456		-	24336571	A375	viability after 14 days	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.9399031169421486	[28]	[56,47]	9	hSpCas9	negative selection	3319439
66711702	66711725		+	24336571	A375	viability after 14 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.3614983817553441	[35]	[39,45]	4	hSpCas9	negative selection	3319440
66781233	66781256	15	-	27383988	293T	resistance to West Nile virus (flavivirus)	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.21027933863716222	[176,176]	[0,0]	-1	hSpCas9	positive selection	3393750
66716433	66716456	15	-	27383988	293T	resistance to West Nile virus (flavivirus)	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	-2.0780641432480897	[645,645]	[0,0]	-9	hSpCas9	positive selection	3393751
66716464	66716487	15	+	27383988	293T	resistance to West Nile virus (flavivirus)	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	2.556886493304743	[25,25]	[0,0]	8	hSpCas9	positive selection	3393752
66711718	66711741	15	-	26780180	HT29	viability (Avana library 4 designs)	AGGAGGGCACACTTACCCAGTGG	SMAD6	ENSG00000137834	0.346731879659923	[]	[]	1	hSpCas9	negative selection	3460581
66711700	66711723	15	-	26780180	HT29	viability (Avana library 4 designs)	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.44764003986307	[]	[]	1	hSpCas9	negative selection	3460582
66711679	66711702	15	-	26780180	HT29	viability (Avana library 4 designs)	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	1.3955590659087	[]	[]	5	hSpCas9	negative selection	3460583
66781076	66781099	15	-	26780180	HT29	viability (Avana library 4 designs)	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	2.02293639896745	[]	[]	7	hSpCas9	negative selection	3460584
66711700	66711723	15	-	26780180	A375	viability (Avana lentiCRISPRv2)	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-4.1502034140348	[]	[]	-5	hSpCas9	negative selection	3561027
66781076	66781099	15	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	1.79728523708758	[]	[]	2	hSpCas9	negative selection	3561028
66711679	66711702	15	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	4.80865284679862	[]	[]	7	hSpCas9	negative selection	3561029
66711718	66711741	15	-	26780180	A375	viability (Avana lentiCRISPRv2)	AGGAGGGCACACTTACCCAGTGG	SMAD6	ENSG00000137834	5.06390551174503	[]	[]	8	hSpCas9	negative selection	3561030
66781102	66781125	15	-	26780180	A375	viability (Avana lentiCRISPRv2)	TAGGTCGTAGAAGATGCTGACGG	SMAD6	ENSG00000137834	0.506224140331951	[]	[]	0	hSpCas9	negative selection	3561031
66716483	66716506	15	-	26780180	A375	viability (Avana lentiCRISPRv2)	TGCTGACCTGAGAATTCACCCGG	SMAD6	ENSG00000137834	0.564663271354181	[]	[]	0	hSpCas9	negative selection	3561032
66711700	66711723	15	-	26780180	A375	viability (Avana lentiGuide)	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.599713363902572	[]	[]	0	hSpCas9	negative selection	3669686
66781076	66781099	15	-	26780180	A375	viability (Avana lentiGuide)	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	6.26509486906011	[]	[]	5	hSpCas9	negative selection	3669687
66711679	66711702	15	-	26780180	A375	viability (Avana lentiGuide)	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	5.98118070829592	[]	[]	5	hSpCas9	negative selection	3669688
66711718	66711741	15	-	26780180	A375	viability (Avana lentiGuide)	AGGAGGGCACACTTACCCAGTGG	SMAD6	ENSG00000137834	-2.86270573024301	[]	[]	-5	hSpCas9	negative selection	3669689
66781102	66781125	15	-	26780180	A375	viability (Avana lentiGuide)	TAGGTCGTAGAAGATGCTGACGG	SMAD6	ENSG00000137834	0.799779151536392	[]	[]	1	hSpCas9	negative selection	3669690
66716483	66716506	15	-	26780180	A375	viability (Avana lentiGuide)	TGCTGACCTGAGAATTCACCCGG	SMAD6	ENSG00000137834	2.55181819745503	[]	[]	2	hSpCas9	negative selection	3669691
66711700	66711723	15	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.5965235531015548	[4]	[1,3]	-7	hSpCas9	positive selection	3778293
66781076	66781099	15	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	-0.14779760648159085	[4]	[4,2]	-2	hSpCas9	positive selection	3778294
66711679	66711702	15	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	0.1752572648882648	[5]	[6,5]	5	hSpCas9	positive selection	3778295
66711718	66711741	15	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AGGAGGGCACACTTACCCAGTGG	SMAD6	ENSG00000137834	0.3947235313003421	[4]	[5,6]	9	hSpCas9	positive selection	3778296
66781102	66781125	15	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TAGGTCGTAGAAGATGCTGACGG	SMAD6	ENSG00000137834	-0.017155939232182393	[5]	[5,5]	0	hSpCas9	positive selection	3778297
66716483	66716506	15	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGCTGACCTGAGAATTCACCCGG	SMAD6	ENSG00000137834	-0.10019506025272262	[6]	[5,5]	-2	hSpCas9	positive selection	3778298
66711700	66711723	15	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.5925498868728282	[5]	[2,3]	-6	hSpCas9	positive selection	3886900
66781076	66781099	15	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	-0.7556923591005869	[4]	[1,2]	-7	hSpCas9	positive selection	3886901
66711679	66711702	15	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	0.1258186990793446	[6]	[5,5]	3	hSpCas9	positive selection	3886902
66711718	66711741	15	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AGGAGGGCACACTTACCCAGTGG	SMAD6	ENSG00000137834	0.16872621277971528	[5]	[5,4]	4	hSpCas9	positive selection	3886903
66781102	66781125	15	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TAGGTCGTAGAAGATGCTGACGG	SMAD6	ENSG00000137834	0.2318009053567082	[5]	[5,5]	6	hSpCas9	positive selection	3886904
66716483	66716506	15	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGCTGACCTGAGAATTCACCCGG	SMAD6	ENSG00000137834	0.1104573207151045	[7]	[7,6]	2	hSpCas9	positive selection	3886905
66711700	66711723	15	-	26780180	A375	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	1.30402708659395	[]	[]	7	hSpCas9	negative selection	3997018
66716464	66716487	15	+	26780180	A375	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.244017203003602	[]	[]	0	hSpCas9	negative selection	3997019
66781079	66781102	15	-	26780180	A375	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	1.07801892587208	[]	[]	5	hSpCas9	negative selection	3997020
66716433	66716456	15	-	26780180	A375	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.243922028433085	[]	[]	0	hSpCas9	negative selection	3997021
66711702	66711725	15	+	26780180	A375	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	1.33083521725093	[]	[]	7	hSpCas9	negative selection	3997022
66781233	66781256	15	-	26780180	A375	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	1.3663248679452	[]	[]	7	hSpCas9	negative selection	3997023
66711700	66711723	15	-	26780180	HT29	viability (GeCKOv2 library)	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	1.18728248765182	[]	[]	6	hSpCas9	negative selection	4104984
66716464	66716487	15	+	26780180	HT29	viability (GeCKOv2 library)	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.452661446631982	[]	[]	1	hSpCas9	negative selection	4104985
66781079	66781102	15	-	26780180	HT29	viability (GeCKOv2 library)	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.423941919661509	[]	[]	1	hSpCas9	negative selection	4104986
66716433	66716456	15	-	26780180	HT29	viability (GeCKOv2 library)	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	-0.161967999276936	[]	[]	-5	hSpCas9	negative selection	4104987
66711702	66711725	15	+	26780180	HT29	viability (GeCKOv2 library)	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	1.08166654079424	[]	[]	5	hSpCas9	negative selection	4104988
66781233	66781256	15	-	26780180	HT29	viability (GeCKOv2 library)	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	1.98599057113099	[]	[]	9	hSpCas9	negative selection	4104989
66716464	66716487	15	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	-0.12367636859270137	[5]	[2,3]	-3	hSpCas9	positive selection	4172134
66716433	66716456	15	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.09095293501275575	[4]	[3,3]	2	hSpCas9	positive selection	4172136
66711702	66711725	15	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.12367814845449748	[4]	[2,4]	3	hSpCas9	positive selection	4172137
66716464	66716487	15	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.4837593795654859	[4]	[5,4,3,0]	3	hSpCas9	positive selection	4236156
66716433	66716456	15	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.433961093191769	[4]	[5,4,3,0]	3	hSpCas9	positive selection	4236158
66711702	66711725	15	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	1.2192417574966035	[4]	[4,4,2,4]	8	hSpCas9	positive selection	4236159
66711702	66711725	15	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.11215012883469146	[2]	[2,0]	-2	hSpCas9	positive selection	4299213
66781079	66781102	15	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.05230320982422276	[3]	[3,1]	1	hSpCas9	positive selection	4299214
66711700	66711723	15	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.058318869354043595	[3]	[3,1]	1	hSpCas9	positive selection	4299215
66781233	66781256	15	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.15914077678585264	[3]	[3,1]	-3	hSpCas9	positive selection	4363466
66716433	66716456	15	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.5141707498020751	[4]	[5,4]	9	hSpCas9	positive selection	4363467
66716464	66716487	15	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.08652054610024162	[1]	[1,0]	1	hSpCas9	positive selection	4363468
66711704	66711726	15	+	27760321	OCIAML3	viability	GCGACGAGTACAAGCCACTGGG	SMAD6	ENSG00000137834	-1.2030413535741	[60,46]	[12,24]	-8	hSpCas9	negative selection	4441218
66716438	66716460	15	+	27760321	OCIAML3	viability	TTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	0.284287559463681	[185,209]	[167,218]	3	hSpCas9	negative selection	4441219
66781034	66781056	15	+	27760321	OCIAML3	viability	CTGGTGCAGCGTGGCGTACTGG	SMAD6	ENSG00000137834	-0.12630441582824703	[595,630]	[481,389]	-1	hSpCas9	negative selection	4441220
66781061	66781083	15	-	27760321	OCIAML3	viability	GAGGCGGCCCACGCGCGTCCGG	SMAD6	ENSG00000137834	0.5454675798393492	[826,700]	[776,988]	6	hSpCas9	negative selection	4441221
66781079	66781101	15	-	27760321	OCIAML3	viability	CTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	-0.023578250342356697	[459,430]	[220,501]	0	hSpCas9	negative selection	4441222
66711704	66711726	15	+	27760321	OCIAML2	viability	GCGACGAGTACAAGCCACTGGG	SMAD6	ENSG00000137834	1.56656899312205	[60,46]	[105,157]	9	hSpCas9	negative selection	4524681
66716438	66716460	15	+	27760321	OCIAML2	viability	TTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	0.5906016462371242	[185,209]	[193,307]	7	hSpCas9	negative selection	4524682
66781034	66781056	15	+	27760321	OCIAML2	viability	CTGGTGCAGCGTGGCGTACTGG	SMAD6	ENSG00000137834	-0.4547550723371079	[595,630]	[320,420]	-5	hSpCas9	negative selection	4524683
66781061	66781083	15	-	27760321	OCIAML2	viability	GAGGCGGCCCACGCGCGTCCGG	SMAD6	ENSG00000137834	-0.16097691528378077	[826,700]	[486,634]	-2	hSpCas9	negative selection	4524684
66781079	66781101	15	-	27760321	OCIAML2	viability	CTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.12166674978330497	[459,430]	[362,430]	1	hSpCas9	negative selection	4524685
66711704	66711726	15	+	27760321	MV411	viability	GCGACGAGTACAAGCCACTGGG	SMAD6	ENSG00000137834	-2.609493419979373	[60,46]	[0,12]	-9	hSpCas9	negative selection	4608144
66716438	66716460	15	+	27760321	MV411	viability	TTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	0.48297954786996233	[185,209]	[90,323]	3	hSpCas9	negative selection	4608145
66781034	66781056	15	+	27760321	MV411	viability	CTGGTGCAGCGTGGCGTACTGG	SMAD6	ENSG00000137834	-0.0019136390092232558	[595,630]	[390,429]	0	hSpCas9	negative selection	4608146
66781061	66781083	15	-	27760321	MV411	viability	GAGGCGGCCCACGCGCGTCCGG	SMAD6	ENSG00000137834	0.6332539824966957	[826,700]	[855,663]	5	hSpCas9	negative selection	4608147
66781079	66781101	15	-	27760321	MV411	viability	CTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.3229848248385089	[459,430]	[98,771]	2	hSpCas9	negative selection	4608148
66711704	66711726	15	+	27760321	HL60	viability	GCGACGAGTACAAGCCACTGGG	SMAD6	ENSG00000137834	-1.2546028414433796	[60,46]	[29,5]	-8	hSpCas9	negative selection	4691607
66716438	66716460	15	+	27760321	HL60	viability	TTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	0.48090515426964253	[185,209]	[180,276]	6	hSpCas9	negative selection	4691608
66781034	66781056	15	+	27760321	HL60	viability	CTGGTGCAGCGTGGCGTACTGG	SMAD6	ENSG00000137834	0.33616261549855314	[595,630]	[576,698]	4	hSpCas9	negative selection	4691609
66781061	66781083	15	-	27760321	HL60	viability	GAGGCGGCCCACGCGCGTCCGG	SMAD6	ENSG00000137834	-0.6747712670346514	[826,700]	[375,403]	-6	hSpCas9	negative selection	4691610
66781079	66781101	15	-	27760321	HL60	viability	CTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.3068729257160388	[459,430]	[481,416]	4	hSpCas9	negative selection	4691611
66711704	66711726	15	+	27760321	HT1080	viability	GCGACGAGTACAAGCCACTGGG	SMAD6	ENSG00000137834	-0.40840481283493313	[46,36]	[14,9]	-2	hSpCas9	negative selection	4775070
66716438	66716460	15	+	27760321	HT1080	viability	TTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	-0.23882453254236102	[209,163]	[86,36]	-1	hSpCas9	negative selection	4775071
66781034	66781056	15	+	27760321	HT1080	viability	CTGGTGCAGCGTGGCGTACTGG	SMAD6	ENSG00000137834	-0.5850756452173619	[630,492]	[122,177]	-3	hSpCas9	negative selection	4775072
66781061	66781083	15	-	27760321	HT1080	viability	GAGGCGGCCCACGCGCGTCCGG	SMAD6	ENSG00000137834	1.612459532747189	[700,546]	[1035,457]	8	hSpCas9	negative selection	4775073
66781079	66781101	15	-	27760321	HT1080	viability	CTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.9192672016725512	[430,336]	[211,373]	5	hSpCas9	negative selection	4775074
66711704	66711726	15	+	27760321	HT29	viability after 7 days	GCGACGAGTACAAGCCACTGGG	SMAD6	ENSG00000137834	0.4522649833348864	[46,36]	[157,12,62]	7	hSpCas9	negative selection	4858533
66716438	66716460	15	+	27760321	HT29	viability after 7 days	TTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	-0.229770686284535	[209,163]	[153,135,313]	-3	hSpCas9	negative selection	4858534
66781034	66781056	15	+	27760321	HT29	viability after 7 days	CTGGTGCAGCGTGGCGTACTGG	SMAD6	ENSG00000137834	-0.40966368124301666	[630,492]	[617,424,596]	-6	hSpCas9	negative selection	4858535
66781061	66781083	15	-	27760321	HT29	viability after 7 days	GAGGCGGCCCACGCGCGTCCGG	SMAD6	ENSG00000137834	0.17279628652886614	[700,546]	[988,676,1052]	2	hSpCas9	negative selection	4858536
66781079	66781101	15	-	27760321	HT29	viability after 7 days	CTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	-0.21980299277683357	[430,336]	[409,391,465]	-3	hSpCas9	negative selection	4858537
66711704	66711726	15	+	27760321	HT29	viability after 25 days	GCGACGAGTACAAGCCACTGGG	SMAD6	ENSG00000137834	-1.1474815276954322	[46,36]	[20,39,1]	-7	hSpCas9	negative selection	4941996
66716438	66716460	15	+	27760321	HT29	viability after 25 days	TTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	0.30276377127053056	[209,163]	[108,368,328]	3	hSpCas9	negative selection	4941997
66781034	66781056	15	+	27760321	HT29	viability after 25 days	CTGGTGCAGCGTGGCGTACTGG	SMAD6	ENSG00000137834	-0.31687852566557523	[630,492]	[448,450,665]	-3	hSpCas9	negative selection	4941998
66781061	66781083	15	-	27760321	HT29	viability after 25 days	GAGGCGGCCCACGCGCGTCCGG	SMAD6	ENSG00000137834	0.49063610200831553	[700,546]	[1118,746,1145]	5	hSpCas9	negative selection	4941999
66781079	66781101	15	-	27760321	HT29	viability after 25 days	CTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.2494297038034701	[430,336]	[714,394,432]	2	hSpCas9	negative selection	4942000
66711704	66711726	15	+	27760321	HT29	viability after 22 days	GCGACGAGTACAAGCCACTGGG	SMAD6	ENSG00000137834	-0.562655853445079	[46,36]	[47,44,4]	-5	hSpCas9	negative selection	5025459
66716438	66716460	15	+	27760321	HT29	viability after 22 days	TTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	0.09946780376222841	[209,163]	[91,335,270]	1	hSpCas9	negative selection	5025460
66781034	66781056	15	+	27760321	HT29	viability after 22 days	CTGGTGCAGCGTGGCGTACTGG	SMAD6	ENSG00000137834	0.08162976497829377	[630,492]	[815,680,560]	0	hSpCas9	negative selection	5025461
66781061	66781083	15	-	27760321	HT29	viability after 22 days	GAGGCGGCCCACGCGCGTCCGG	SMAD6	ENSG00000137834	0.3974388927689766	[700,546]	[1013,854,979]	4	hSpCas9	negative selection	5025462
66781079	66781101	15	-	27760321	HT29	viability after 22 days	CTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.4856231943284248	[430,336]	[761,594,502]	5	hSpCas9	negative selection	5025463
66711704	66711726	15	+	27760321	HT29	viability after 19 days	GCGACGAGTACAAGCCACTGGG	SMAD6	ENSG00000137834	0.6043877611737596	[46,36]	[48,23,140]	6	hSpCas9	negative selection	5108922
66716438	66716460	15	+	27760321	HT29	viability after 19 days	TTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	-0.1834011646923317	[209,163]	[116,159,276]	-2	hSpCas9	negative selection	5108923
66781034	66781056	15	+	27760321	HT29	viability after 19 days	CTGGTGCAGCGTGGCGTACTGG	SMAD6	ENSG00000137834	-0.4597013134781363	[630,492]	[453,546,401]	-4	hSpCas9	negative selection	5108924
66781061	66781083	15	-	27760321	HT29	viability after 19 days	GAGGCGGCCCACGCGCGTCCGG	SMAD6	ENSG00000137834	0.4508707019046688	[700,546]	[1339,785,842]	4	hSpCas9	negative selection	5108925
66781079	66781101	15	-	27760321	HT29	viability after 19 days	CTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.8397841374128434	[430,336]	[912,508,942]	8	hSpCas9	negative selection	5108926
66711704	66711726	15	+	27760321	HT29	viability after 16 days	GCGACGAGTACAAGCCACTGGG	SMAD6	ENSG00000137834	0.6656646816227609	[46,36]	[82,17,124]	7	hSpCas9	negative selection	5192385
66716438	66716460	15	+	27760321	HT29	viability after 16 days	TTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	0.1928991329769263	[209,163]	[93,189,420]	2	hSpCas9	negative selection	5192386
66781034	66781056	15	+	27760321	HT29	viability after 16 days	CTGGTGCAGCGTGGCGTACTGG	SMAD6	ENSG00000137834	-0.1742195003801985	[630,492]	[627,458,593]	-2	hSpCas9	negative selection	5192387
66781061	66781083	15	-	27760321	HT29	viability after 16 days	GAGGCGGCCCACGCGCGTCCGG	SMAD6	ENSG00000137834	0.2910803360389632	[700,546]	[744,935,868]	3	hSpCas9	negative selection	5192388
66781079	66781101	15	-	27760321	HT29	viability after 16 days	CTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.4944868150136361	[430,336]	[634,669,511]	5	hSpCas9	negative selection	5192389
66711704	66711726	15	+	27760321	HT29	viability after 13 days	GCGACGAGTACAAGCCACTGGG	SMAD6	ENSG00000137834	-0.29292151210011497	[46,36]	[58,14,44]	-4	hSpCas9	negative selection	5275848
66716438	66716460	15	+	27760321	HT29	viability after 13 days	TTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	0.14372147909443622	[209,163]	[172,218,321]	1	hSpCas9	negative selection	5275849
66781034	66781056	15	+	27760321	HT29	viability after 13 days	CTGGTGCAGCGTGGCGTACTGG	SMAD6	ENSG00000137834	-0.3134122522390277	[630,492]	[473,538,558]	-4	hSpCas9	negative selection	5275850
66781061	66781083	15	-	27760321	HT29	viability after 13 days	GAGGCGGCCCACGCGCGTCCGG	SMAD6	ENSG00000137834	0.34219252804931377	[700,546]	[1037,1042,685]	4	hSpCas9	negative selection	5275851
66781079	66781101	15	-	27760321	HT29	viability after 13 days	CTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.1251545984452007	[430,336]	[569,325,556]	1	hSpCas9	negative selection	5275852
66711704	66711726	15	+	27760321	HT29	viability after 10 days	GCGACGAGTACAAGCCACTGGG	SMAD6	ENSG00000137834	1.0921408380568685	[46,36]	[21,100,209]	9	hSpCas9	negative selection	5359311
66716438	66716460	15	+	27760321	HT29	viability after 10 days	TTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	-0.08345140776564142	[209,163]	[273,134,248]	-1	hSpCas9	negative selection	5359312
66781034	66781056	15	+	27760321	HT29	viability after 10 days	CTGGTGCAGCGTGGCGTACTGG	SMAD6	ENSG00000137834	-0.3496854015311537	[630,492]	[573,680,403]	-4	hSpCas9	negative selection	5359313
66781061	66781083	15	-	27760321	HT29	viability after 10 days	GAGGCGGCCCACGCGCGTCCGG	SMAD6	ENSG00000137834	0.05080447225801632	[700,546]	[793,954,678]	0	hSpCas9	negative selection	5359314
66781079	66781101	15	-	27760321	HT29	viability after 10 days	CTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	-0.0929302400146582	[430,336]	[531,418,397]	-1	hSpCas9	negative selection	5359315
66711704	66711726	15	+	27760321	MOLM13	viability	GCGACGAGTACAAGCCACTGGG	SMAD6	ENSG00000137834	-1.2928343178501698	[60,46]	[0,21]	-6	hSpCas9	negative selection	5442774
66716438	66716460	15	+	27760321	MOLM13	viability	TTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	-0.14678757994948577	[185,209]	[111,92]	-1	hSpCas9	negative selection	5442775
66781034	66781056	15	+	27760321	MOLM13	viability	CTGGTGCAGCGTGGCGTACTGG	SMAD6	ENSG00000137834	0.09230254516611641	[595,630]	[174,537]	0	hSpCas9	negative selection	5442776
66781061	66781083	15	-	27760321	MOLM13	viability	GAGGCGGCCCACGCGCGTCCGG	SMAD6	ENSG00000137834	-0.03428881545477869	[826,700]	[641,229]	0	hSpCas9	negative selection	5442777
66781079	66781101	15	-	27760321	MOLM13	viability	CTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	-0.3310077177724052	[459,430]	[267,141]	-2	hSpCas9	negative selection	5442778
66702379	66702402	15	-	27661255	K562	viability	GGTCCCAGCGAGGTCTGGCGAGG	SMAD6	ENSG00000137834	-0.041158068540193576	[898,942]	[661,758]	-2	dCas9-KRAB	negative selection	5512787
66711702	66711725	15	+	27260156	BXPC3	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.0652234495085316	[373]	[398,390,389,461]	1	hSpCas9	negative selection	5571673
66781079	66781102	15	-	27260156	BXPC3	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	-0.1549345864248365	[459]	[527,409,335,440]	-4	hSpCas9	negative selection	5571674
66711700	66711723	15	-	27260156	BXPC3	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.04381304265526581	[528]	[359,532,633,650]	-1	hSpCas9	negative selection	5571675
66781233	66781256	15	-	27260156	BXPC3	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.13689446725659285	[563]	[454,436,655,620]	-3	hSpCas9	negative selection	5635926
66716433	66716456	15	-	27260156	BXPC3	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.06849012907640839	[1174]	[1184,1197,1305,1497]	1	hSpCas9	negative selection	5635927
66716464	66716487	15	+	27260156	BXPC3	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.0531590440429861	[66]	[86,44,48,113]	1	hSpCas9	negative selection	5635928
66711702	66711725	15	+	27260156	A673	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.03871071840167817	[373]	[432,394,512,404]	-1	hSpCas9	negative selection	5692924
66781079	66781102	15	-	27260156	A673	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	-0.19330318432168378	[459]	[555,502,426,451]	-5	hSpCas9	negative selection	5692925
66711700	66711723	15	-	27260156	A673	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.24742121408265505	[528]	[541,561,480,555]	-6	hSpCas9	negative selection	5692926
66781233	66781256	15	-	27260156	A673	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.4805551198046709	[563]	[680,462,422,391]	-8	hSpCas9	negative selection	5757177
66716433	66716456	15	-	27260156	A673	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	-0.08881129468133575	[1174]	[1690,1159,1197,1300]	-2	hSpCas9	negative selection	5757178
66716464	66716487	15	+	27260156	A673	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.055136663344915515	[66]	[45,67,99,117]	1	hSpCas9	negative selection	5757179
66711702	66711725	15	+	27260156	A375	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.0036464995526521715	[373]	[373,645,452,311]	0	hSpCas9	negative selection	5814175
66781079	66781102	15	-	27260156	A375	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	-0.4209103319223424	[459]	[367,568,308,382]	-5	hSpCas9	negative selection	5814176
66711700	66711723	15	-	27260156	A375	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.16002002570943402	[528]	[598,633,606,399]	-2	hSpCas9	negative selection	5814177
66781233	66781256	15	-	27260156	A375	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	0.03420486165263964	[563]	[816,910,534,488]	0	hSpCas9	negative selection	5878428
66716433	66716456	15	-	27260156	A375	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.21232240003169434	[1174]	[1511,1737,1600,1529]	3	hSpCas9	negative selection	5878429
66716464	66716487	15	+	27260156	A375	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	-0.5620391755494603	[66]	[59,73,38,42]	-6	hSpCas9	negative selection	5878430
66711702	66711725	15	+	27260156	COLO741	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.1028904136143432	[373]	[506,497,341]	-2	hSpCas9	negative selection	5935426
66781079	66781102	15	-	27260156	COLO741	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.11470923526452245	[459]	[726,506,677]	2	hSpCas9	negative selection	5935427
66711700	66711723	15	-	27260156	COLO741	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.8711164935393294	[528]	[312,460,331]	-9	hSpCas9	negative selection	5935428
66781233	66781256	15	-	27260156	COLO741	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.2468270703817539	[563]	[820,559,467]	-5	hSpCas9	negative selection	5999679
66716433	66716456	15	-	27260156	COLO741	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	-0.1459118070678891	[1174]	[1663,1433,1020]	-3	hSpCas9	negative selection	5999680
66716464	66716487	15	+	27260156	COLO741	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	-0.4242338301164308	[66]	[61,49,77]	-7	hSpCas9	negative selection	5999681
66711702	66711725	15	+	27260156	CAL120	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.30228454363190443	[373]	[310,314,493]	-4	hSpCas9	negative selection	6056677
66781079	66781102	15	-	27260156	CAL120	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.37612183426517104	[459]	[1079,559,640]	5	hSpCas9	negative selection	6056678
66711700	66711723	15	-	27260156	CAL120	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.18892369541511472	[528]	[489,592,634]	-3	hSpCas9	negative selection	6056679
66781233	66781256	15	-	27260156	CAL120	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	0.12309110127385137	[563]	[805,561,927]	1	hSpCas9	negative selection	6120930
66716433	66716456	15	-	27260156	CAL120	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.5022985686493022	[1174]	[3056,1748,1563]	7	hSpCas9	negative selection	6120931
66716464	66716487	15	+	27260156	CAL120	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.12281936982912578	[66]	[55,115,94]	1	hSpCas9	negative selection	6120932
66711702	66711725	15	+	27260156	CADOES1	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.14039442709266253	[373]	[299,430,308,218]	-2	hSpCas9	negative selection	6177928
66781079	66781102	15	-	27260156	CADOES1	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	-0.04311720674934811	[459]	[499,392,394,370]	0	hSpCas9	negative selection	6177929
66711700	66711723	15	-	27260156	CADOES1	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.27377037619045863	[528]	[521,369,391,340]	-5	hSpCas9	negative selection	6177930
66781233	66781256	15	-	27260156	CADOES1	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.20689286546255167	[563]	[349,511,584,367]	-4	hSpCas9	negative selection	6242181
66716433	66716456	15	-	27260156	CADOES1	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.09927351136319706	[1174]	[981,1238,1246,1216]	1	hSpCas9	negative selection	6242182
66716464	66716487	15	+	27260156	CADOES1	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.9438844408477829	[66]	[113,111,196,53]	9	hSpCas9	negative selection	6242183
66711702	66711725	15	+	27260156	EWS502	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.19510367524563826	[373]	[341,329,665,498]	3	hSpCas9	negative selection	6299179
66781079	66781102	15	-	27260156	EWS502	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.4338176901484566	[459]	[565,767,732,563]	7	hSpCas9	negative selection	6299180
66711700	66711723	15	-	27260156	EWS502	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.5455877616277264	[528]	[316,444,389,387]	-7	hSpCas9	negative selection	6299181
66781233	66781256	15	-	27260156	EWS502	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	0.16808823836824377	[563]	[651,754,667,600]	3	hSpCas9	negative selection	6363432
66716433	66716456	15	-	27260156	EWS502	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.002992724652775447	[1174]	[1078,1118,1274,1558]	0	hSpCas9	negative selection	6363433
66716464	66716487	15	+	27260156	EWS502	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	-0.5833580613817615	[66]	[39,34,83,30]	-7	hSpCas9	negative selection	6363434
66711702	66711725	15	+	27260156	EW8	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.004464235669568384	[373]	[359,175,291,386]	0	hSpCas9	negative selection	6420430
66781079	66781102	15	-	27260156	EW8	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	-0.17995282482119415	[459]	[350,394,234,352]	-3	hSpCas9	negative selection	6420431
66711700	66711723	15	-	27260156	EW8	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.06227852133859631	[528]	[547,414,354,347]	-1	hSpCas9	negative selection	6420432
66781233	66781256	15	-	27260156	EW8	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.2706463550292951	[563]	[526,422,297,296]	-5	hSpCas9	negative selection	6484683
66716433	66716456	15	-	27260156	EW8	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.13766105292740405	[1174]	[1348,1042,898,954]	2	hSpCas9	negative selection	6484684
66716464	66716487	15	+	27260156	EW8	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.06997991215126342	[66]	[83,30,30,88]	1	hSpCas9	negative selection	6484685
66711702	66711725	15	+	27260156	CORL105	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.057770237125310486	[373]	[470,329,646,273]	-1	hSpCas9	negative selection	6541681
66781079	66781102	15	-	27260156	CORL105	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	-0.2795206169780264	[459]	[454,537,471,312]	-5	hSpCas9	negative selection	6541682
66711700	66711723	15	-	27260156	CORL105	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.4667104970615601	[528]	[423,465,540,374]	-7	hSpCas9	negative selection	6541683
66781233	66781256	15	-	27260156	CORL105	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.3303345329778266	[563]	[743,458,569,343]	-6	hSpCas9	negative selection	6605934
66716433	66716456	15	-	27260156	CORL105	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	-0.09901711778122246	[1174]	[1212,1171,1491,1291]	-2	hSpCas9	negative selection	6605935
66716464	66716487	15	+	27260156	CORL105	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	-0.8686709355951958	[66]	[41,12,28,85]	-9	hSpCas9	negative selection	6605936
66711702	66711725	15	+	27260156	HS294T	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.4800169705083751	[373]	[127,191,284,209]	6	hSpCas9	negative selection	6662932
66781079	66781102	15	-	27260156	HS294T	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.22451694109265727	[459]	[121,263,222,231]	3	hSpCas9	negative selection	6662933
66711700	66711723	15	-	27260156	HS294T	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.4859670887897005	[528]	[109,141,160,179]	-6	hSpCas9	negative selection	6662934
66781233	66781256	15	-	27260156	HS294T	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.2590344359375739	[563]	[170,187,178,192]	-4	hSpCas9	negative selection	6727185
66716433	66716456	15	-	27260156	HS294T	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	-0.09120977166285149	[1174]	[496,407,367,424]	-1	hSpCas9	negative selection	6727186
66716464	66716487	15	+	27260156	HS294T	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.001410798169885652	[66]	[18,15,36,33]	0	hSpCas9	negative selection	6727187
66711702	66711725	15	+	27260156	HCC44	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.15473086636302757	[373]	[341,315,424,444]	-3	hSpCas9	negative selection	6784183
66781079	66781102	15	-	27260156	HCC44	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	-0.27467574102353615	[459]	[387,419,390,505]	-4	hSpCas9	negative selection	6784184
66711700	66711723	15	-	27260156	HCC44	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.07448128753939312	[528]	[725,532,512,507]	-1	hSpCas9	negative selection	6784185
66781233	66781256	15	-	27260156	HCC44	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	0.04959064944497127	[563]	[876,419,1000,456]	0	hSpCas9	negative selection	6848436
66716433	66716456	15	-	27260156	HCC44	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.07533347769935972	[1174]	[1578,1267,1630,1192]	1	hSpCas9	negative selection	6848437
66716464	66716487	15	+	27260156	HCC44	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.8048252873601993	[66]	[118,155,220,45]	9	hSpCas9	negative selection	6848438
66711702	66711725	15	+	27260156	G402	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.01089374177214908	[373]	[475,613,536,232]	0	hSpCas9	negative selection	6905434
66781079	66781102	15	-	27260156	G402	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.08310390992149423	[459]	[485,851,542,498]	1	hSpCas9	negative selection	6905435
66711700	66711723	15	-	27260156	G402	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.21285064555462618	[528]	[572,724,600,348]	-3	hSpCas9	negative selection	6905436
66781233	66781256	15	-	27260156	G402	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.48276044633667914	[563]	[433,347,503,656]	-6	hSpCas9	negative selection	6969687
66716433	66716456	15	-	27260156	G402	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.2073937165985189	[1174]	[1712,2146,1453,1352]	2	hSpCas9	negative selection	6969688
66716464	66716487	15	+	27260156	G402	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	-0.050271142315224004	[66]	[37,187,75,16]	0	hSpCas9	negative selection	6969689
66711702	66711725	15	+	27260156	L33	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.20304197810887079	[373]	[439,224,266,308]	4	hSpCas9	negative selection	7026685
66781079	66781102	15	-	27260156	L33	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.2955420720041612	[459]	[680,250,260,545]	6	hSpCas9	negative selection	7026686
66711700	66711723	15	-	27260156	L33	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.19582818527596596	[528]	[493,217,254,414]	-4	hSpCas9	negative selection	7026687
66781233	66781256	15	-	27260156	L33	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.1388163425907113	[563]	[480,184,344,567]	-3	hSpCas9	negative selection	7090938
66716433	66716456	15	-	27260156	L33	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.14367994525515382	[1174]	[1246,520,848,1323]	3	hSpCas9	negative selection	7090939
66716464	66716487	15	+	27260156	L33	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.7714472161806967	[66]	[67,57,61,149]	9	hSpCas9	negative selection	7090940
66711702	66711725	15	+	27260156	K562	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.18004582821179899	[373]	[420,174,173,392]	-2	hSpCas9	negative selection	7147936
66781079	66781102	15	-	27260156	K562	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	-0.21011633291812168	[459]	[562,465,190,227]	-3	hSpCas9	negative selection	7147937
66711700	66711723	15	-	27260156	K562	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.1207719664832716	[528]	[353,499,517,358]	-1	hSpCas9	negative selection	7147938
66781233	66781256	15	-	27260156	K562	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.22441236309865853	[563]	[365,406,545,390]	-3	hSpCas9	negative selection	7212189
66716433	66716456	15	-	27260156	K562	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	-0.11926390824982724	[1174]	[1013,826,1019,970]	-1	hSpCas9	negative selection	7212190
66716464	66716487	15	+	27260156	K562	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	-1.0806243584401645	[66]	[48,8,35,19]	-8	hSpCas9	negative selection	7212191
66711702	66711725	15	+	27260156	HT29	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.13131983297118366	[373]	[411,589,370,311]	-3	hSpCas9	negative selection	7269187
66781079	66781102	15	-	27260156	HT29	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.09642248486217217	[459]	[681,609,634,481]	1	hSpCas9	negative selection	7269188
66711700	66711723	15	-	27260156	HT29	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.21540638068737605	[528]	[560,493,715,448]	-4	hSpCas9	negative selection	7269189
66781233	66781256	15	-	27260156	HT29	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.2028551931458314	[563]	[464,733,861,349]	-4	hSpCas9	negative selection	7333440
66716433	66716456	15	-	27260156	HT29	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.06533350550574935	[1174]	[1835,1531,1388,1267]	1	hSpCas9	negative selection	7333441
66716464	66716487	15	+	27260156	HT29	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.46188176098078015	[66]	[51,198,107,93]	8	hSpCas9	negative selection	7333442
66711702	66711725	15	+	27260156	MHHES1	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.04148818950743072	[373]	[383,442,518,384]	0	hSpCas9	negative selection	7390438
66781079	66781102	15	-	27260156	MHHES1	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.20772632304567396	[459]	[769,818,510,374]	4	hSpCas9	negative selection	7390439
66711700	66711723	15	-	27260156	MHHES1	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.24055548773195196	[528]	[650,419,503,451]	-4	hSpCas9	negative selection	7390440
66781233	66781256	15	-	27260156	MHHES1	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.44101035036847164	[563]	[431,402,464,533]	-7	hSpCas9	negative selection	7454691
66716433	66716456	15	-	27260156	MHHES1	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	-0.16830962340942635	[1174]	[1279,1882,871,815]	-3	hSpCas9	negative selection	7454692
66716464	66716487	15	+	27260156	MHHES1	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.11053025962583796	[66]	[107,35,108,71]	2	hSpCas9	negative selection	7454693
66711702	66711725	15	+	27260156	MEWO	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.2593159437525295	[373]	[306,247,324]	-5	hSpCas9	negative selection	7511689
66781079	66781102	15	-	27260156	MEWO	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.30255864501087304	[459]	[581,556,462]	6	hSpCas9	negative selection	7511690
66711700	66711723	15	-	27260156	MEWO	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.22097248723032958	[528]	[538,413,342]	-5	hSpCas9	negative selection	7511691
66781233	66781256	15	-	27260156	MEWO	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.262784123194759	[563]	[457,398,465]	-5	hSpCas9	negative selection	7575942
66716433	66716456	15	-	27260156	MEWO	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.06380008073251431	[1174]	[1298,1102,1073]	1	hSpCas9	negative selection	7575943
66716464	66716487	15	+	27260156	MEWO	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	-0.12163803357278491	[66]	[68,64,40]	-3	hSpCas9	negative selection	7575944
66711702	66711725	15	+	27260156	LNCAPCLONEFGC	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.2665798000599393	[373]	[399,329,412,492]	4	hSpCas9	negative selection	7632940
66781079	66781102	15	-	27260156	LNCAPCLONEFGC	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.5423285715946106	[459]	[454,563,702,724]	8	hSpCas9	negative selection	7632941
66711700	66711723	15	-	27260156	LNCAPCLONEFGC	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.26339649272010046	[528]	[281,368,520,446]	-4	hSpCas9	negative selection	7632942
66781233	66781256	15	-	27260156	LNCAPCLONEFGC	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	0.209623157593545	[563]	[595,571,725,489]	3	hSpCas9	negative selection	7697193
66716433	66716456	15	-	27260156	LNCAPCLONEFGC	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.3499129207359972	[1174]	[1415,1231,1394,1394]	5	hSpCas9	negative selection	7697194
66716464	66716487	15	+	27260156	LNCAPCLONEFGC	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.6470887402077263	[66]	[138,28,137,83]	8	hSpCas9	negative selection	7697195
66711702	66711725	15	+	27260156	PANC0327	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.7765328728320714	[373]	[329,1115,433,305]	9	hSpCas9	negative selection	7754191
66781079	66781102	15	-	27260156	PANC0327	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.310108407754874	[459]	[538,529,523,432]	4	hSpCas9	negative selection	7754192
66711700	66711723	15	-	27260156	PANC0327	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.16339277297055452	[528]	[315,555,334,444]	-2	hSpCas9	negative selection	7754193
66781233	66781256	15	-	27260156	PANC0327	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.12098194189629335	[563]	[419,401,521,502]	-2	hSpCas9	negative selection	7818444
66716433	66716456	15	-	27260156	PANC0327	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.4284659996508715	[1174]	[1643,737,1532,1808]	6	hSpCas9	negative selection	7818445
66716464	66716487	15	+	27260156	PANC0327	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	-0.07903140329519909	[66]	[32,105,31,45]	-1	hSpCas9	negative selection	7818446
66711702	66711725	15	+	27260156	NCIH2009	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.03302726165598491	[373]	[787,428,437]	0	hSpCas9	negative selection	7875442
66781079	66781102	15	-	27260156	NCIH2009	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.011587691625947964	[459]	[673,795,474]	0	hSpCas9	negative selection	7875443
66711700	66711723	15	-	27260156	NCIH2009	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.5080503645645345	[528]	[470,498,578]	-6	hSpCas9	negative selection	7875444
66781233	66781256	15	-	27260156	NCIH2009	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.004332372984835686	[563]	[1002,869,523]	0	hSpCas9	negative selection	7939695
66716433	66716456	15	-	27260156	NCIH2009	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.28445891451414873	[1174]	[1940,2133,1905]	4	hSpCas9	negative selection	7939696
66716464	66716487	15	+	27260156	NCIH2009	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.24952028420054972	[66]	[69,138,115]	3	hSpCas9	negative selection	7939697
66711702	66711725	15	+	27260156	NCIH1373	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.12700694545506486	[373]	[242,234,424,167]	-1	hSpCas9	negative selection	7996693
66781079	66781102	15	-	27260156	NCIH1373	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.23012300580964598	[459]	[636,295,965,142]	2	hSpCas9	negative selection	7996694
66711700	66711723	15	-	27260156	NCIH1373	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.4130080919203152	[528]	[449,311,618,106]	-4	hSpCas9	negative selection	7996695
66781233	66781256	15	-	27260156	NCIH1373	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	0.726854449298619	[563]	[1362,819,1013,277]	7	hSpCas9	negative selection	8060946
66716433	66716456	15	-	27260156	NCIH1373	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.3591312909827509	[1174]	[2576,1146,1538,442]	3	hSpCas9	negative selection	8060947
66716464	66716487	15	+	27260156	NCIH1373	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	-0.39519138810894505	[66]	[18,84,71,10]	-4	hSpCas9	negative selection	8060948
66711702	66711725	15	+	27260156	PATU8902	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.05815528741361986	[373]	[514,455,414,650]	0	hSpCas9	negative selection	8117944
66781079	66781102	15	-	27260156	PATU8902	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.08294743282553946	[459]	[966,442,628,677]	0	hSpCas9	negative selection	8117945
66711700	66711723	15	-	27260156	PATU8902	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.5896692516475488	[528]	[708,484,394,372]	-5	hSpCas9	negative selection	8117946
66781233	66781256	15	-	27260156	PATU8902	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.6128778192575344	[563]	[425,521,357,822]	-5	hSpCas9	negative selection	8182197
66716433	66716456	15	-	27260156	PATU8902	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.39035140873121454	[1174]	[1381,1890,2310,3052]	4	hSpCas9	negative selection	8182198
66716464	66716487	15	+	27260156	PATU8902	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	-1.3535580075355185	[66]	[45,15,68,1]	-8	hSpCas9	negative selection	8182199
66711702	66711725	15	+	27260156	PANC1	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.09755917780602705	[373]	[411,479,250,264]	1	hSpCas9	negative selection	8239195
66781079	66781102	15	-	27260156	PANC1	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.09151348444406887	[459]	[388,679,455,236]	1	hSpCas9	negative selection	8239196
66711700	66711723	15	-	27260156	PANC1	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.4610723808070468	[528]	[357,327,307,320]	-6	hSpCas9	negative selection	8239197
66781233	66781256	15	-	27260156	PANC1	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.03096710395946367	[563]	[456,633,409,427]	0	hSpCas9	negative selection	8303448
66716433	66716456	15	-	27260156	PANC1	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.5137007865664684	[1174]	[1432,1962,1164,1305]	8	hSpCas9	negative selection	8303449
66716464	66716487	15	+	27260156	PANC1	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.32160596293078747	[66]	[154,105,25,13]	5	hSpCas9	negative selection	8303450
66711702	66711725	15	+	27260156	PANC0813	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.5274071505590623	[373]	[694,338,548,936]	8	hSpCas9	negative selection	8360446
66781079	66781102	15	-	27260156	PANC0813	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.5044534440626773	[459]	[921,615,769,770]	7	hSpCas9	negative selection	8360447
66711700	66711723	15	-	27260156	PANC0813	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.13054925396788392	[528]	[634,650,420,567]	-2	hSpCas9	negative selection	8360448
66781233	66781256	15	-	27260156	PANC0813	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	0.05883183818816334	[563]	[430,816,477,990]	1	hSpCas9	negative selection	8424699
66716433	66716456	15	-	27260156	PANC0813	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.14333647307718644	[1174]	[1684,1328,1671,1429]	2	hSpCas9	negative selection	8424700
66716464	66716487	15	+	27260156	PANC0813	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	-0.7520633413076689	[66]	[51,30,50,52]	-8	hSpCas9	negative selection	8424701
66711702	66711725	15	+	27260156	RDES	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.050465461007302925	[373]	[352,470,483,484]	0	hSpCas9	negative selection	8481697
66781079	66781102	15	-	27260156	RDES	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	-0.21960691605188537	[459]	[300,487,594,455]	-4	hSpCas9	negative selection	8481698
66711700	66711723	15	-	27260156	RDES	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.23758400799735618	[528]	[408,349,636,729]	-4	hSpCas9	negative selection	8481699
66781233	66781256	15	-	27260156	RDES	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.3326761896578626	[563]	[403,422,574,707]	-5	hSpCas9	negative selection	8545950
66716433	66716456	15	-	27260156	RDES	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.02784114946278682	[1174]	[1121,1315,1519,1612]	0	hSpCas9	negative selection	8545951
66716464	66716487	15	+	27260156	RDES	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.06639227536158554	[66]	[54,83,67,124]	1	hSpCas9	negative selection	8545952
66711702	66711725	15	+	27260156	PC3	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.1353335416164645	[373]	[238,357,580,276]	-3	hSpCas9	negative selection	8602948
66781079	66781102	15	-	27260156	PC3	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.3785858993892759	[459]	[371,466,1190,636]	7	hSpCas9	negative selection	8602949
66711700	66711723	15	-	27260156	PC3	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.07924427698256742	[528]	[281,475,1003,482]	-2	hSpCas9	negative selection	8602950
66781233	66781256	15	-	27260156	PC3	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.2331246162655821	[563]	[322,447,865,445]	-5	hSpCas9	negative selection	8667201
66716433	66716456	15	-	27260156	PC3	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.17638040227219975	[1174]	[909,1296,2118,1319]	4	hSpCas9	negative selection	8667202
66716464	66716487	15	+	27260156	PC3	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.4471232381341399	[66]	[36,53,117,189]	8	hSpCas9	negative selection	8667203
66711702	66711725	15	+	27260156	PATU8988T	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.1471732292840536	[373]	[255,607,344,412]	2	hSpCas9	negative selection	8724199
66781079	66781102	15	-	27260156	PATU8988T	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	-0.15106810701603451	[459]	[332,325,428,514]	-3	hSpCas9	negative selection	8724200
66711700	66711723	15	-	27260156	PATU8988T	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.12291615588652224	[528]	[540,504,438,389]	-2	hSpCas9	negative selection	8724201
66781233	66781256	15	-	27260156	PATU8988T	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.30083965467965834	[563]	[440,542,355,439]	-5	hSpCas9	negative selection	8788452
66716433	66716456	15	-	27260156	PATU8988T	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.2716717569752085	[1174]	[1201,1490,1544,1242]	5	hSpCas9	negative selection	8788453
66716464	66716487	15	+	27260156	PATU8988T	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.4231341939188611	[66]	[71,58,165,42]	7	hSpCas9	negative selection	8788454
66711702	66711725	15	+	27260156	T47D	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.014357218068139221	[373]	[529,342,489,403]	0	hSpCas9	negative selection	8845450
66781079	66781102	15	-	27260156	T47D	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.05505370189824888	[459]	[501,594,487,641]	1	hSpCas9	negative selection	8845451
66711700	66711723	15	-	27260156	T47D	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.010207146711713383	[528]	[675,520,730,522]	0	hSpCas9	negative selection	8845452
66781233	66781256	15	-	27260156	T47D	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.07665475376965902	[563]	[731,547,685,528]	-2	hSpCas9	negative selection	8909703
66716433	66716456	15	-	27260156	T47D	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.10258029123868706	[1174]	[1492,1460,1404,1522]	2	hSpCas9	negative selection	8909704
66716464	66716487	15	+	27260156	T47D	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.04112884194945998	[66]	[58,98,90,69]	0	hSpCas9	negative selection	8909705
66711702	66711725	15	+	27260156	SU8686	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.2610005000168708	[373]	[289,485,498,525]	4	hSpCas9	negative selection	8966701
66781079	66781102	15	-	27260156	SU8686	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.3027622164742148	[459]	[512,454,600,723]	5	hSpCas9	negative selection	8966702
66711700	66711723	15	-	27260156	SU8686	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.06379068944766761	[528]	[618,383,470,535]	-1	hSpCas9	negative selection	8966703
66781233	66781256	15	-	27260156	SU8686	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	0.01290397268888871	[563]	[451,507,703,621]	0	hSpCas9	negative selection	9030954
66716433	66716456	15	-	27260156	SU8686	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.22725683629034732	[1174]	[1093,1203,1615,1632]	4	hSpCas9	negative selection	9030955
66716464	66716487	15	+	27260156	SU8686	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	-0.11122240846330333	[66]	[41,50,64,96]	-2	hSpCas9	negative selection	9030956
66711702	66711725	15	+	27260156	SKES1	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.0005127089141095942	[373]	[398,438,326,339]	0	hSpCas9	negative selection	9087952
66781079	66781102	15	-	27260156	SKES1	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.012654981418721529	[459]	[441,573,521,333]	0	hSpCas9	negative selection	9087953
66711700	66711723	15	-	27260156	SKES1	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.29587435173147647	[528]	[465,449,335,466]	-6	hSpCas9	negative selection	9087954
66781233	66781256	15	-	27260156	SKES1	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.2049263655180498	[563]	[487,614,382,478]	-4	hSpCas9	negative selection	9152205
66716433	66716456	15	-	27260156	SKES1	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	-0.0684039076149987	[1174]	[1219,1486,941,897]	-1	hSpCas9	negative selection	9152206
66716464	66716487	15	+	27260156	SKES1	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	-0.05587791475980186	[66]	[89,88,44,41]	-1	hSpCas9	negative selection	9152207
66711702	66711725	15	+	27260156	TOV112D	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.19613760425333857	[373]	[307,608,480,353]	4	hSpCas9	negative selection	9209203
66781079	66781102	15	-	27260156	TOV112D	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.5692577403920506	[459]	[504,815,790,639]	8	hSpCas9	negative selection	9209204
66711700	66711723	15	-	27260156	TOV112D	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.1277321937966205	[528]	[937,776,225,455]	2	hSpCas9	negative selection	9209205
66781233	66781256	15	-	27260156	TOV112D	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.023033989777497432	[563]	[535,473,636,553]	0	hSpCas9	negative selection	9273456
66716433	66716456	15	-	27260156	TOV112D	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.161783348667778	[1174]	[1309,1634,1059,1335]	3	hSpCas9	negative selection	9273457
66716464	66716487	15	+	27260156	TOV112D	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.05588716539005878	[66]	[23,137,101,28]	1	hSpCas9	negative selection	9273458
66711702	66711725	15	+	27260156	TC71	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.09238334606218374	[373]	[364,383,351,405]	-2	hSpCas9	negative selection	9330454
66781079	66781102	15	-	27260156	TC71	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.054994231587379316	[459]	[386,564,548,551]	1	hSpCas9	negative selection	9330455
66711700	66711723	15	-	27260156	TC71	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.07226944338274699	[528]	[480,523,554,601]	-2	hSpCas9	negative selection	9330456
66781233	66781256	15	-	27260156	TC71	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	-0.2985683141974903	[563]	[404,540,527,492]	-7	hSpCas9	negative selection	9394707
66716433	66716456	15	-	27260156	TC71	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.08758149659699854	[1174]	[1250,1357,1455,1282]	2	hSpCas9	negative selection	9394708
66716464	66716487	15	+	27260156	TC71	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	0.23466285565016376	[66]	[84,73,100,76]	6	hSpCas9	negative selection	9394709
66711702	66711725	15	+	27260156	TC32	viability	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	0.18035851387050203	[373]	[303,313,521,500]	3	hSpCas9	negative selection	9451705
66781079	66781102	15	-	27260156	TC32	viability	CCTGGTCGTACACCGCATAGAGG	SMAD6	ENSG00000137834	0.3656303923186201	[459]	[351,571,702,614]	6	hSpCas9	negative selection	9451706
66711700	66711723	15	-	27260156	TC32	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.17583841193131253	[528]	[505,287,588,424]	-3	hSpCas9	negative selection	9451707
66781233	66781256	15	-	27260156	TC32	viability	TTGTAGGCCCACACGCCGTCGGG	SMAD6	ENSG00000137834	0.06065605564956189	[563]	[593,396,679,583]	1	hSpCas9	negative selection	9515958
66716433	66716456	15	-	27260156	TC32	viability	CGTTTCAGTGTAAGACAATGTGG	SMAD6	ENSG00000137834	0.19616045894236667	[1174]	[1131,960,1599,1494]	3	hSpCas9	negative selection	9515959
66716464	66716487	15	+	27260156	TC32	viability	CAACTCCCTCATCACTGCTCCGG	SMAD6	ENSG00000137834	-0.14694462512330198	[66]	[93,38,45,43]	-3	hSpCas9	negative selection	9515960
66703782	66703805	15	+	27869803	HPAFII	viability after 27 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	0.3584034297550629	[470]	[485,176,NaN]	3	hSpCas9	negative selection	9554441
66703939	66703962	15	-	27869803	HPAFII	viability after 27 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	-0.48627596007181395	[147]	[60,50,NaN]	-4	hSpCas9	negative selection	9554442
66711702	66711725	15	+	27869803	HPAFII	viability after 27 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.8800200955093244	[266]	[108,48,NaN]	-6	hSpCas9	negative selection	9554443
66711700	66711723	15	-	27869803	HPAFII	viability after 27 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.5052381544736261	[239]	[237,129,NaN]	4	hSpCas9	negative selection	9554444
66717040	66717063	15	-	27869803	HPAFII	viability after 27 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	-0.32651672748794824	[473]	[219,180,NaN]	-2	hSpCas9	negative selection	9554445
66781079	66781102	15	+	27869803	HPAFII	viability after 27 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	-1.6596067114599666	[58]	[17,2,NaN]	-8	hSpCas9	negative selection	9554446
66703782	66703805	15	+	27869803	HPAFII	viability after 15 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	0.5505493963652828	[470]	[1082,528,NaN]	6	hSpCas9	negative selection	9636890
66703939	66703962	15	-	27869803	HPAFII	viability after 15 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	-0.6418522014219975	[147]	[170,58,NaN]	-6	hSpCas9	negative selection	9636891
66711702	66711725	15	+	27869803	HPAFII	viability after 15 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.9890214880134442	[266]	[204,106,NaN]	-7	hSpCas9	negative selection	9636892
66711700	66711723	15	-	27869803	HPAFII	viability after 15 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.2970398826377183	[239]	[364,286,NaN]	3	hSpCas9	negative selection	9636893
66717040	66717063	15	-	27869803	HPAFII	viability after 15 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	-0.28077395741685873	[473]	[562,329,NaN]	-3	hSpCas9	negative selection	9636894
66781079	66781102	15	+	27869803	HPAFII	viability after 15 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	-3.558101791261406	[58]	[5,4,NaN]	-9	hSpCas9	negative selection	9636895
66703782	66703805	15	+	27869803	ASPC1	viability after 36 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	0.13866989745759772	[1463]	[1131,446,248]	1	hSpCas9	negative selection	9719339
66703939	66703962	15	-	27869803	ASPC1	viability after 36 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	-0.07345822574237415	[405]	[73,199,123]	0	hSpCas9	negative selection	9719340
66711702	66711725	15	+	27869803	ASPC1	viability after 36 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.5014965245526265	[611]	[212,137,115]	-5	hSpCas9	negative selection	9719341
66711700	66711723	15	-	27869803	ASPC1	viability after 36 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-1.6185869447048513	[570]	[84,54,57]	-8	hSpCas9	negative selection	9719342
66717040	66717063	15	-	27869803	ASPC1	viability after 36 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	-0.36429513652597423	[1236]	[229,163,541]	-4	hSpCas9	negative selection	9719343
66781079	66781102	15	+	27869803	ASPC1	viability after 36 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	-1.2863698786806825	[96]	[0,0,32]	-8	hSpCas9	negative selection	9719344
66703782	66703805	15	+	27869803	PATU8988S	viability after 35 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	-0.020739707944513852	[968]	[469,298,NaN]	0	hSpCas9	negative selection	9801788
66703939	66703962	15	-	27869803	PATU8988S	viability after 35 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	-0.47563423313882425	[363]	[73,136,NaN]	-5	hSpCas9	negative selection	9801789
66711702	66711725	15	+	27869803	PATU8988S	viability after 35 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.4332364878095865	[510]	[116,187,NaN]	-4	hSpCas9	negative selection	9801790
66711700	66711723	15	-	27869803	PATU8988S	viability after 35 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.14059396159243742	[505]	[290,157,NaN]	1	hSpCas9	negative selection	9801791
66717040	66717063	15	-	27869803	PATU8988S	viability after 35 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	-0.017698145341004	[1018]	[360,449,NaN]	0	hSpCas9	negative selection	9801792
66781079	66781102	15	+	27869803	PATU8988S	viability after 35 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	-2.334554617339379	[74]	[0,10,NaN]	-9	hSpCas9	negative selection	9801793
66703782	66703805	15	+	27869803	PATU8988S	viability after 31 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	-0.11929216567341872	[968]	[349,362,NaN]	-1	hSpCas9	negative selection	9884237
66703939	66703962	15	-	27869803	PATU8988S	viability after 31 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	-0.6304672586887398	[363]	[80,109,NaN]	-6	hSpCas9	negative selection	9884238
66711702	66711725	15	+	27869803	PATU8988S	viability after 31 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-0.3906464663525682	[510]	[77,253,NaN]	-4	hSpCas9	negative selection	9884239
66711700	66711723	15	-	27869803	PATU8988S	viability after 31 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.3984544847473994	[505]	[116,198,NaN]	-4	hSpCas9	negative selection	9884240
66717040	66717063	15	-	27869803	PATU8988S	viability after 31 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	-0.26564010299273366	[1018]	[282,407,NaN]	-3	hSpCas9	negative selection	9884241
66781079	66781102	15	+	27869803	PATU8988S	viability after 31 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	-1.523651152521437	[74]	[16,1,NaN]	-8	hSpCas9	negative selection	9884242
66703782	66703805	15	+	27869803	HPAFII	viability after 35 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	0.7560938697573139	[470]	[643,130,NaN]	5	hSpCas9	negative selection	9966686
66703939	66703962	15	-	27869803	HPAFII	viability after 35 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	-1.2680271628160087	[147]	[16,46,NaN]	-6	hSpCas9	negative selection	9966687
66711702	66711725	15	+	27869803	HPAFII	viability after 35 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-1.2502262598752472	[266]	[53,59,NaN]	-6	hSpCas9	negative selection	9966688
66711700	66711723	15	-	27869803	HPAFII	viability after 35 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.6889473920320447	[239]	[169,224,NaN]	4	hSpCas9	negative selection	9966689
66717040	66717063	15	-	27869803	HPAFII	viability after 35 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	0.12872580022512237	[473]	[267,255,NaN]	0	hSpCas9	negative selection	9966690
66781079	66781102	15	+	27869803	HPAFII	viability after 35 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	-2.433367823894723	[58]	[5,4,NaN]	-8	hSpCas9	negative selection	9966691
66703782	66703805	15	+	27869803	HPAFII	viability after 31 days	TCACGTACTCGCTGCTGAAGCGG	SMAD6	ENSG00000137834	0.69101114534371	[470]	[621,213,NaN]	5	hSpCas9	negative selection	10049135
66703939	66703962	15	-	27869803	HPAFII	viability after 31 days	GGTCGGGCCAGCGAAAGAGGCGG	SMAD6	ENSG00000137834	-0.7926232558229235	[147]	[57,36,NaN]	-5	hSpCas9	negative selection	10049136
66711702	66711725	15	+	27869803	HPAFII	viability after 31 days	TCGCGACGAGTACAAGCCACTGG	SMAD6	ENSG00000137834	-1.534833766986695	[266]	[22,82,NaN]	-7	hSpCas9	negative selection	10049137
66711700	66711723	15	-	27869803	HPAFII	viability after 31 days	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.9405010743816739	[239]	[157,367,NaN]	7	hSpCas9	negative selection	10049138
66717040	66717063	15	-	27869803	HPAFII	viability after 31 days	GGACAGAGGACTCCAAACCACGG	SMAD6	ENSG00000137834	-0.40099174967574225	[473]	[222,177,NaN]	-3	hSpCas9	negative selection	10049139
66781079	66781102	15	+	27869803	HPAFII	viability after 31 days	CCTCTATGCGGTGTACGACCAGG	SMAD6	ENSG00000137834	-1.900105408411069	[58]	[5,11,NaN]	-8	hSpCas9	negative selection	10049140
66711679	66711702	15	-	28162770	P31FUJ	viability	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	-0.11250797069666696	[45]	[49]	-1	hSpCas9	negative selection	10238750
66781053	66781076	15	+	28162770	P31FUJ	viability	TGGGAGCACCGGACGCGCGTGGG	SMAD6	ENSG00000137834	0.9697769631389165	[198]	[457]	9	hSpCas9	negative selection	10238751
66716437	66716460	15	+	28162770	P31FUJ	viability	ATTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	-0.29218075149331013	[123]	[118]	-3	hSpCas9	negative selection	10238752
66716463	66716486	15	-	28162770	P31FUJ	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	0.9608017934974443	[187]	[429]	9	hSpCas9	negative selection	10238753
66711700	66711723	15	-	28162770	P31FUJ	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.22337398965795152	[362]	[497]	2	hSpCas9	negative selection	10238754
66716477	66716500	15	+	28162770	P31FUJ	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	1.2140580196779895	[240]	[656]	9	hSpCas9	negative selection	10238755
66781496	66781519	15	-	28162770	P31FUJ	viability	GGAGGATCTCCAGCCAGCAGGGG	SMAD6	ENSG00000137834	-0.8001060386390281	[202]	[136]	-6	hSpCas9	negative selection	10238756
66781076	66781099	15	-	28162770	P31FUJ	viability	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	-0.12328871966788812	[316]	[341]	-1	hSpCas9	negative selection	10238757
66781239	66781262	15	+	28162770	P31FUJ	viability	GGCGTGTGGGCCTACAACCGCGG	SMAD6	ENSG00000137834	-0.24828745191179746	[280]	[277]	-2	hSpCas9	negative selection	10238758
66781031	66781054	15	-	28162770	P31FUJ	viability	AGTACGCCACGCTGCACCAGTGG	SMAD6	ENSG00000137834	0.5474984775902736	[222]	[382]	6	hSpCas9	negative selection	10238759
66711679	66711702	15	-	28162770	TF1	viability	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	NaN	[NaN]	[46]	1	hSpCas9	negative selection	10408116
66781053	66781076	15	+	28162770	TF1	viability	TGGGAGCACCGGACGCGCGTGGG	SMAD6	ENSG00000137834	NaN	[NaN]	[190]	1	hSpCas9	negative selection	10408117
66716437	66716460	15	+	28162770	TF1	viability	ATTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	NaN	[NaN]	[84]	1	hSpCas9	negative selection	10408118
66716463	66716486	15	-	28162770	TF1	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	NaN	[NaN]	[166]	1	hSpCas9	negative selection	10408119
66711700	66711723	15	-	28162770	TF1	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	NaN	[NaN]	[356]	1	hSpCas9	negative selection	10408120
66716477	66716500	15	+	28162770	TF1	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	NaN	[NaN]	[115]	1	hSpCas9	negative selection	10408121
66781496	66781519	15	-	28162770	TF1	viability	GGAGGATCTCCAGCCAGCAGGGG	SMAD6	ENSG00000137834	NaN	[NaN]	[145]	1	hSpCas9	negative selection	10408122
66781076	66781099	15	-	28162770	TF1	viability	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	NaN	[NaN]	[140]	1	hSpCas9	negative selection	10408123
66781239	66781262	15	+	28162770	TF1	viability	GGCGTGTGGGCCTACAACCGCGG	SMAD6	ENSG00000137834	NaN	[NaN]	[162]	1	hSpCas9	negative selection	10408124
66781031	66781054	15	-	28162770	TF1	viability	AGTACGCCACGCTGCACCAGTGG	SMAD6	ENSG00000137834	NaN	[NaN]	[219]	1	hSpCas9	negative selection	10408125
66711679	66711702	15	-	28162770	SKM1	viability	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	0.06552357271958198	[19]	[36]	0	hSpCas9	negative selection	10577482
66781053	66781076	15	+	28162770	SKM1	viability	TGGGAGCACCGGACGCGCGTGGG	SMAD6	ENSG00000137834	0.2104197796703719	[43]	[89]	2	hSpCas9	negative selection	10577483
66716437	66716460	15	+	28162770	SKM1	viability	ATTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	0.13952415416335878	[37]	[73]	1	hSpCas9	negative selection	10577484
66716463	66716486	15	-	28162770	SKM1	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	0.2849135058945063	[64]	[139]	2	hSpCas9	negative selection	10577485
66711700	66711723	15	-	28162770	SKM1	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.3844491794454208	[90]	[209]	4	hSpCas9	negative selection	10577486
66716477	66716500	15	+	28162770	SKM1	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	0.8800934362971484	[66]	[217]	8	hSpCas9	negative selection	10577487
66781496	66781519	15	-	28162770	SKM1	viability	GGAGGATCTCCAGCCAGCAGGGG	SMAD6	ENSG00000137834	0.5228267989754356	[49]	[126]	5	hSpCas9	negative selection	10577488
66781076	66781099	15	-	28162770	SKM1	viability	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	0.5972235982202716	[85]	[229]	6	hSpCas9	negative selection	10577489
66781239	66781262	15	+	28162770	SKM1	viability	GGCGTGTGGGCCTACAACCGCGG	SMAD6	ENSG00000137834	0.24328976222971366	[53]	[112]	2	hSpCas9	negative selection	10577490
66781031	66781054	15	-	28162770	SKM1	viability	AGTACGCCACGCTGCACCAGTGG	SMAD6	ENSG00000137834	0.4370855232951255	[60]	[145]	4	hSpCas9	negative selection	10577491
66711679	66711702	15	-	28162770	SKM1	viability	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	0.06552357271958198	[19]	[36]	0	hSpCas9	negative selection	10746848
66781053	66781076	15	+	28162770	SKM1	viability	TGGGAGCACCGGACGCGCGTGGG	SMAD6	ENSG00000137834	0.2104197796703719	[43]	[89]	2	hSpCas9	negative selection	10746849
66716437	66716460	15	+	28162770	SKM1	viability	ATTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	0.13952415416335878	[37]	[73]	1	hSpCas9	negative selection	10746850
66716463	66716486	15	-	28162770	SKM1	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	0.2849135058945063	[64]	[139]	2	hSpCas9	negative selection	10746851
66711700	66711723	15	-	28162770	SKM1	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.3844491794454208	[90]	[209]	4	hSpCas9	negative selection	10746852
66716477	66716500	15	+	28162770	SKM1	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	0.8800934362971484	[66]	[217]	8	hSpCas9	negative selection	10746853
66781496	66781519	15	-	28162770	SKM1	viability	GGAGGATCTCCAGCCAGCAGGGG	SMAD6	ENSG00000137834	0.5228267989754356	[49]	[126]	5	hSpCas9	negative selection	10746854
66781076	66781099	15	-	28162770	SKM1	viability	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	0.5972235982202716	[85]	[229]	6	hSpCas9	negative selection	10746855
66781239	66781262	15	+	28162770	SKM1	viability	GGCGTGTGGGCCTACAACCGCGG	SMAD6	ENSG00000137834	0.24328976222971366	[53]	[112]	2	hSpCas9	negative selection	10746856
66781031	66781054	15	-	28162770	SKM1	viability	AGTACGCCACGCTGCACCAGTGG	SMAD6	ENSG00000137834	0.4370855232951255	[60]	[145]	4	hSpCas9	negative selection	10746857
66711679	66711702	15	-	28162770	PL21	viability	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	-2.092642134738526	[48]	[4]	-8	hSpCas9	negative selection	10916214
66781053	66781076	15	+	28162770	PL21	viability	TGGGAGCACCGGACGCGCGTGGG	SMAD6	ENSG00000137834	0.38722516708981547	[129]	[73]	3	hSpCas9	negative selection	10916215
66716437	66716460	15	+	28162770	PL21	viability	ATTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	0.09745395051475608	[130]	[60]	0	hSpCas9	negative selection	10916216
66716463	66716486	15	-	28162770	PL21	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	-0.102423155531111	[184]	[74]	0	hSpCas9	negative selection	10916217
66711700	66711723	15	-	28162770	PL21	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.04551271311623728	[395]	[166]	0	hSpCas9	negative selection	10916218
66716477	66716500	15	+	28162770	PL21	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	1.3342762871408562	[194]	[213]	9	hSpCas9	negative selection	10916219
66781496	66781519	15	-	28162770	PL21	viability	GGAGGATCTCCAGCCAGCAGGGG	SMAD6	ENSG00000137834	-0.9302570227663549	[161]	[36]	-6	hSpCas9	negative selection	10916220
66781076	66781099	15	-	28162770	PL21	viability	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	0.7315866058834744	[237]	[171]	6	hSpCas9	negative selection	10916221
66781239	66781262	15	+	28162770	PL21	viability	GGCGTGTGGGCCTACAACCGCGG	SMAD6	ENSG00000137834	0.17602715837251254	[180]	[88]	1	hSpCas9	negative selection	10916222
66781031	66781054	15	-	28162770	PL21	viability	AGTACGCCACGCTGCACCAGTGG	SMAD6	ENSG00000137834	1.2615401591534634	[183]	[191]	9	hSpCas9	negative selection	10916223
66711679	66711702	15	-	28162770	P31FUJ	viability	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	-0.11250797069666696	[45]	[49]	-1	hSpCas9	negative selection	11085580
66781053	66781076	15	+	28162770	P31FUJ	viability	TGGGAGCACCGGACGCGCGTGGG	SMAD6	ENSG00000137834	0.9697769631389165	[198]	[457]	9	hSpCas9	negative selection	11085581
66716437	66716460	15	+	28162770	P31FUJ	viability	ATTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	-0.29218075149331013	[123]	[118]	-3	hSpCas9	negative selection	11085582
66716463	66716486	15	-	28162770	P31FUJ	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	0.9608017934974443	[187]	[429]	9	hSpCas9	negative selection	11085583
66711700	66711723	15	-	28162770	P31FUJ	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.22337398965795152	[362]	[497]	2	hSpCas9	negative selection	11085584
66716477	66716500	15	+	28162770	P31FUJ	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	1.2140580196779895	[240]	[656]	9	hSpCas9	negative selection	11085585
66781496	66781519	15	-	28162770	P31FUJ	viability	GGAGGATCTCCAGCCAGCAGGGG	SMAD6	ENSG00000137834	-0.8001060386390281	[202]	[136]	-6	hSpCas9	negative selection	11085586
66781076	66781099	15	-	28162770	P31FUJ	viability	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	-0.12328871966788812	[316]	[341]	-1	hSpCas9	negative selection	11085587
66781239	66781262	15	+	28162770	P31FUJ	viability	GGCGTGTGGGCCTACAACCGCGG	SMAD6	ENSG00000137834	-0.24828745191179746	[280]	[277]	-2	hSpCas9	negative selection	11085588
66781031	66781054	15	-	28162770	P31FUJ	viability	AGTACGCCACGCTGCACCAGTGG	SMAD6	ENSG00000137834	0.5474984775902736	[222]	[382]	6	hSpCas9	negative selection	11085589
66711679	66711702	15	-	28162770	OCIAML5	viability	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	-1.4472248386910418	[70]	[46]	-7	hSpCas9	negative selection	11254946
66781053	66781076	15	+	28162770	OCIAML5	viability	TGGGAGCACCGGACGCGCGTGGG	SMAD6	ENSG00000137834	0.38374636623477243	[106]	[251]	3	hSpCas9	negative selection	11254947
66716437	66716460	15	+	28162770	OCIAML5	viability	ATTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	-0.852066570863997	[96]	[96]	-5	hSpCas9	negative selection	11254948
66716463	66716486	15	-	28162770	OCIAML5	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	0.3046589328234563	[121]	[271]	2	hSpCas9	negative selection	11254949
66711700	66711723	15	-	28162770	OCIAML5	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.007147321396766992	[241]	[438]	0	hSpCas9	negative selection	11254950
66716477	66716500	15	+	28162770	OCIAML5	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	0.9790565171265571	[85]	[305]	8	hSpCas9	negative selection	11254951
66781496	66781519	15	-	28162770	OCIAML5	viability	GGAGGATCTCCAGCCAGCAGGGG	SMAD6	ENSG00000137834	0.297680548640685	[95]	[212]	2	hSpCas9	negative selection	11254952
66781076	66781099	15	-	28162770	OCIAML5	viability	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	0.43230197664867276	[178]	[435]	4	hSpCas9	negative selection	11254953
66781239	66781262	15	+	28162770	OCIAML5	viability	GGCGTGTGGGCCTACAACCGCGG	SMAD6	ENSG00000137834	-0.24354934216394383	[161]	[246]	-2	hSpCas9	negative selection	11254954
66781031	66781054	15	-	28162770	OCIAML5	viability	AGTACGCCACGCTGCACCAGTGG	SMAD6	ENSG00000137834	0.35768441107150384	[130]	[302]	3	hSpCas9	negative selection	11254955
66711679	66711702	15	-	28162770	EOL1	viability	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	-1.6256493109899453	[122]	[20]	-7	hSpCas9	negative selection	11424312
66781053	66781076	15	+	28162770	EOL1	viability	TGGGAGCACCGGACGCGCGTGGG	SMAD6	ENSG00000137834	0.7439755259287136	[220]	[194]	6	hSpCas9	negative selection	11424313
66716437	66716460	15	+	28162770	EOL1	viability	ATTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	0.2933296798885059	[205]	[132]	2	hSpCas9	negative selection	11424314
66716463	66716486	15	-	28162770	EOL1	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	-0.6486375613742679	[365]	[122]	-5	hSpCas9	negative selection	11424315
66711700	66711723	15	-	28162770	EOL1	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	-0.016386287564947866	[669]	[348]	0	hSpCas9	negative selection	11424316
66716477	66716500	15	+	28162770	EOL1	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	0.7756843856560518	[458]	[413]	6	hSpCas9	negative selection	11424317
66781496	66781519	15	-	28162770	EOL1	viability	GGAGGATCTCCAGCCAGCAGGGG	SMAD6	ENSG00000137834	-0.11541863574711009	[182]	[88]	-1	hSpCas9	negative selection	11424318
66781076	66781099	15	-	28162770	EOL1	viability	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	0.4004675129964007	[347]	[241]	3	hSpCas9	negative selection	11424319
66781239	66781262	15	+	28162770	EOL1	viability	GGCGTGTGGGCCTACAACCGCGG	SMAD6	ENSG00000137834	-0.27776040372258104	[213]	[92]	-2	hSpCas9	negative selection	11424320
66781031	66781054	15	-	28162770	EOL1	viability	AGTACGCCACGCTGCACCAGTGG	SMAD6	ENSG00000137834	0.8187531075479376	[197]	[183]	7	hSpCas9	negative selection	11424321
66711679	66711702	15	-	28162770	MOLM13	viability	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	1.3313873816397168	[71]	[130]	8	hSpCas9	negative selection	11593678
66781053	66781076	15	+	28162770	MOLM13	viability	TGGGAGCACCGGACGCGCGTGGG	SMAD6	ENSG00000137834	0.18898857025176385	[255]	[210]	1	hSpCas9	negative selection	11593679
66716437	66716460	15	+	28162770	MOLM13	viability	ATTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	-0.35778043789310765	[217]	[122]	-2	hSpCas9	negative selection	11593680
66716463	66716486	15	-	28162770	MOLM13	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	1.2205416129514268	[310]	[523]	8	hSpCas9	negative selection	11593681
66711700	66711723	15	-	28162770	MOLM13	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.46788938154457893	[520]	[520]	3	hSpCas9	negative selection	11593682
66716477	66716500	15	+	28162770	MOLM13	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	0.5966226956667815	[374]	[409]	4	hSpCas9	negative selection	11593683
66781496	66781519	15	-	28162770	MOLM13	viability	GGAGGATCTCCAGCCAGCAGGGG	SMAD6	ENSG00000137834	0.24161352572090283	[185]	[158]	1	hSpCas9	negative selection	11593684
66781076	66781099	15	-	28162770	MOLM13	viability	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	0.6076141452111921	[353]	[389]	4	hSpCas9	negative selection	11593685
66781239	66781262	15	+	28162770	MOLM13	viability	GGCGTGTGGGCCTACAACCGCGG	SMAD6	ENSG00000137834	0.5887888148967918	[285]	[310]	4	hSpCas9	negative selection	11593686
66781031	66781054	15	-	28162770	MOLM13	viability	AGTACGCCACGCTGCACCAGTGG	SMAD6	ENSG00000137834	-0.11460486358582755	[291]	[194]	0	hSpCas9	negative selection	11593687
66711679	66711702	15	-	28162770	HEL	viability	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	1.8573328827763977	[52]	[122]	9	hSpCas9	negative selection	11763044
66781053	66781076	15	+	28162770	HEL	viability	TGGGAGCACCGGACGCGCGTGGG	SMAD6	ENSG00000137834	0.44069505605571135	[175]	[152]	3	hSpCas9	negative selection	11763045
66716437	66716460	15	+	28162770	HEL	viability	ATTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	-0.8808231240566557	[137]	[47]	-5	hSpCas9	negative selection	11763046
66716463	66716486	15	-	28162770	HEL	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	-0.37912060196338215	[265]	[130]	-3	hSpCas9	negative selection	11763047
66711700	66711723	15	-	28162770	HEL	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.5682606160410805	[476]	[452]	5	hSpCas9	negative selection	11763048
66716477	66716500	15	+	28162770	HEL	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	0.669874961937871	[315]	[321]	6	hSpCas9	negative selection	11763049
66781496	66781519	15	-	28162770	HEL	viability	GGAGGATCTCCAGCCAGCAGGGG	SMAD6	ENSG00000137834	0.12427174306610761	[158]	[110]	1	hSpCas9	negative selection	11763050
66781076	66781099	15	-	28162770	HEL	viability	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	0.028028987885148605	[244]	[159]	0	hSpCas9	negative selection	11763051
66781239	66781262	15	+	28162770	HEL	viability	GGCGTGTGGGCCTACAACCGCGG	SMAD6	ENSG00000137834	0.18685628044413052	[202]	[147]	1	hSpCas9	negative selection	11763052
66781031	66781054	15	-	28162770	HEL	viability	AGTACGCCACGCTGCACCAGTGG	SMAD6	ENSG00000137834	-0.419188917142845	[237]	[113]	-3	hSpCas9	negative selection	11763053
66711679	66711702	15	-	28162770	MV411	viability	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	0.24743755078277507	[36]	[36]	2	hSpCas9	negative selection	11932410
66781053	66781076	15	+	28162770	MV411	viability	TGGGAGCACCGGACGCGCGTGGG	SMAD6	ENSG00000137834	0.36701916653544786	[161]	[175]	3	hSpCas9	negative selection	11932411
66716437	66716460	15	+	28162770	MV411	viability	ATTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	0.9333289603547124	[114]	[184]	8	hSpCas9	negative selection	11932412
66716463	66716486	15	-	28162770	MV411	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	0.2973134574223449	[198]	[205]	2	hSpCas9	negative selection	11932413
66711700	66711723	15	-	28162770	MV411	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.19339771106988612	[407]	[392]	1	hSpCas9	negative selection	11932414
66716477	66716500	15	+	28162770	MV411	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	-0.21275198488844344	[237]	[172]	-2	hSpCas9	negative selection	11932415
66781496	66781519	15	-	28162770	MV411	viability	GGAGGATCTCCAGCCAGCAGGGG	SMAD6	ENSG00000137834	0.6130870230994557	[103]	[133]	5	hSpCas9	negative selection	11932416
66781076	66781099	15	-	28162770	MV411	viability	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	1.000056409260467	[164]	[277]	8	hSpCas9	negative selection	11932417
66781239	66781262	15	+	28162770	MV411	viability	GGCGTGTGGGCCTACAACCGCGG	SMAD6	ENSG00000137834	-1.1078277279786997	[196]	[76]	-6	hSpCas9	negative selection	11932418
66781031	66781054	15	-	28162770	MV411	viability	AGTACGCCACGCTGCACCAGTGG	SMAD6	ENSG00000137834	-0.005777794020572796	[204]	[171]	0	hSpCas9	negative selection	11932419
66711679	66711702	15	-	28162770	MONOMAC1	viability	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	-1.944270776679587	[46]	[13]	-8	hSpCas9	negative selection	12101776
66781053	66781076	15	+	28162770	MONOMAC1	viability	TGGGAGCACCGGACGCGCGTGGG	SMAD6	ENSG00000137834	-0.1970368470595536	[109]	[109]	-2	hSpCas9	negative selection	12101777
66716437	66716460	15	+	28162770	MONOMAC1	viability	ATTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	0.2953595349255296	[58]	[82]	3	hSpCas9	negative selection	12101778
66716463	66716486	15	-	28162770	MONOMAC1	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	0.5510447793008266	[180]	[303]	5	hSpCas9	negative selection	12101779
66711700	66711723	15	-	28162770	MONOMAC1	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.006496547025578447	[230]	[265]	0	hSpCas9	negative selection	12101780
66716477	66716500	15	+	28162770	MONOMAC1	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	0.2807364075672526	[134]	[187]	3	hSpCas9	negative selection	12101781
66781496	66781519	15	-	28162770	MONOMAC1	viability	GGAGGATCTCCAGCCAGCAGGGG	SMAD6	ENSG00000137834	-0.16141293732883244	[79]	[81]	-1	hSpCas9	negative selection	12101782
66781076	66781099	15	-	28162770	MONOMAC1	viability	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	0.42354956339232397	[159]	[245]	4	hSpCas9	negative selection	12101783
66781239	66781262	15	+	28162770	MONOMAC1	viability	GGCGTGTGGGCCTACAACCGCGG	SMAD6	ENSG00000137834	0.08675611894103769	[91]	[111]	0	hSpCas9	negative selection	12101784
66781031	66781054	15	-	28162770	MONOMAC1	viability	AGTACGCCACGCTGCACCAGTGG	SMAD6	ENSG00000137834	0.9392846241532267	[110]	[243]	8	hSpCas9	negative selection	12101785
66711679	66711702	15	-	28162770	OCIAML2	viability	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	-0.19761133083574522	[5]	[28]	-2	hSpCas9	negative selection	12271142
66781053	66781076	15	+	28162770	OCIAML2	viability	TGGGAGCACCGGACGCGCGTGGG	SMAD6	ENSG00000137834	0.5549052668649763	[27]	[227]	5	hSpCas9	negative selection	12271143
66716437	66716460	15	+	28162770	OCIAML2	viability	ATTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	-0.3710941516912466	[20]	[89]	-3	hSpCas9	negative selection	12271144
66716463	66716486	15	-	28162770	OCIAML2	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	0.019175442438654988	[46]	[263]	0	hSpCas9	negative selection	12271145
66711700	66711723	15	-	28162770	OCIAML2	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.8971019592583259	[61]	[639]	8	hSpCas9	negative selection	12271146
66716477	66716500	15	+	28162770	OCIAML2	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	0.9306207223066068	[45]	[485]	8	hSpCas9	negative selection	12271147
66781496	66781519	15	-	28162770	OCIAML2	viability	GGAGGATCTCCAGCCAGCAGGGG	SMAD6	ENSG00000137834	0.4507603400614725	[32]	[249]	4	hSpCas9	negative selection	12271148
66781076	66781099	15	-	28162770	OCIAML2	viability	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	0.9345116378941827	[31]	[338]	8	hSpCas9	negative selection	12271149
66781239	66781262	15	+	28162770	OCIAML2	viability	GGCGTGTGGGCCTACAACCGCGG	SMAD6	ENSG00000137834	-0.37109415169124677	[34]	[149]	-3	hSpCas9	negative selection	12271150
66781031	66781054	15	-	28162770	OCIAML2	viability	AGTACGCCACGCTGCACCAGTGG	SMAD6	ENSG00000137834	0.2635586842534713	[25]	[172]	2	hSpCas9	negative selection	12271151
66711679	66711702	15	-	28162770	OCIAML3	viability	GGAGACAGCCGAGAGTAGGGAGG	SMAD6	ENSG00000137834	-3.7639326417664756	[8]	[1]	-9	hSpCas9	negative selection	12440508
66781053	66781076	15	+	28162770	OCIAML3	viability	TGGGAGCACCGGACGCGCGTGGG	SMAD6	ENSG00000137834	0.009333389711847651	[51]	[157]	0	hSpCas9	negative selection	12440509
66716437	66716460	15	+	28162770	OCIAML3	viability	ATTGTCTTACACTGAAACGGAGG	SMAD6	ENSG00000137834	-0.6484554243465396	[26]	[51]	-5	hSpCas9	negative selection	12440510
66716463	66716486	15	-	28162770	OCIAML3	viability	CGGAGCAGTGATGAGGGAGTTGG	SMAD6	ENSG00000137834	-0.3138997211314279	[55]	[135]	-2	hSpCas9	negative selection	12440511
66711700	66711723	15	-	28162770	OCIAML3	viability	AGTGGCTTGTACTCGTCGCGAGG	SMAD6	ENSG00000137834	0.1918675543229893	[86]	[299]	1	hSpCas9	negative selection	12440512
66716477	66716500	15	+	28162770	OCIAML3	viability	ACTGCTCCGGGTGAATTCTCAGG	SMAD6	ENSG00000137834	0.20317547667614974	[60]	[211]	2	hSpCas9	negative selection	12440513
66781496	66781519	15	-	28162770	OCIAML3	viability	GGAGGATCTCCAGCCAGCAGGGG	SMAD6	ENSG00000137834	-0.9810307634334106	[50]	[77]	-6	hSpCas9	negative selection	12440514
66781076	66781099	15	-	28162770	OCIAML3	viability	GGTCGTACACCGCATAGAGGCGG	SMAD6	ENSG00000137834	-0.41567039906565073	[75]	[171]	-3	hSpCas9	negative selection	12440515
66781239	66781262	15	+	28162770	OCIAML3	viability	GGCGTGTGGGCCTACAACCGCGG	SMAD6	ENSG00000137834	0.3235301994838639	[71]	[271]	3	hSpCas9	negative selection	12440516
66781031	66781054	15	-	28162770	OCIAML3	viability	AGTACGCCACGCTGCACCAGTGG	SMAD6	ENSG00000137834	0.2665893030104204	[56]	[206]	2	hSpCas9	negative selection	12440517