Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:4092
• Symbol:SMAD7
• Description:SMAD family member 7

DataSource: http://genomecrispr.dkfz.de/#!/results/SMAD7

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
48942514	48942537	18	-	26472758	Jiyoye	viability	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.050240836790597876	[72]	[56]	0	hSpCas9	negative selection	151599
48921449	48921472	18	-	26472758	Jiyoye	viability	CGTGCAGATCAGCTTTGTGAAGG	SMAD7	ENSG00000101665	1.5144086048309011	[161]	[348]	8	hSpCas9	negative selection	151600
48942492	48942515	18	-	26472758	Jiyoye	viability	GGAACGAATTATCTGGCCCCTGG	SMAD7	ENSG00000101665	0.8894115806726173	[193]	[270]	6	hSpCas9	negative selection	151601
48921694	48921717	18	-	26472758	Jiyoye	viability	GTGCGGAGCAAAATCGGCTGCGG	SMAD7	ENSG00000101665	2.0401179111288514	[68]	[213]	8	hSpCas9	negative selection	151602
48921548	48921571	18	+	26472758	Jiyoye	viability	AAGCCTTGATGGAGAAACCGGGG	SMAD7	ENSG00000101665	0.3120181484655334	[93]	[87]	2	hSpCas9	negative selection	151603
48921828	48921851	18	-	26472758	Jiyoye	viability	AGGAGAAGACGAGAGTGGGGAGG	SMAD7	ENSG00000101665	1.4071753815058727	[0]	[1]	8	hSpCas9	negative selection	151604
48921678	48921701	18	-	26472758	Jiyoye	viability	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	1.276591271695729	[103]	[189]	7	hSpCas9	negative selection	151605
48921597	48921620	18	+	26472758	Jiyoye	viability	GGAGTCCGGGTTGTCCAGTGTGG	SMAD7	ENSG00000101665	0.6751085867525064	[48]	[58]	5	hSpCas9	negative selection	151606
48921516	48921539	18	-	26472758	Jiyoye	viability	AGAAGGCGTACAGCCTGCAGCGG	SMAD7	ENSG00000101665	0.8303868122304172	[43]	[58]	6	hSpCas9	negative selection	151607
48921483	48921506	18	-	26472758	Jiyoye	viability	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.06322098028851186	[65]	[51]	0	hSpCas9	negative selection	151608
48942514	48942537	18	-	26472758	KBM7	viability	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.31260572693766464	[247,215]	[178,95]	3	hSpCas9	negative selection	342717
48921449	48921472	18	-	26472758	KBM7	viability	CGTGCAGATCAGCTTTGTGAAGG	SMAD7	ENSG00000101665	0.48018069265693186	[1238,1362]	[1057,685]	5	hSpCas9	negative selection	342718
48942492	48942515	18	-	26472758	KBM7	viability	GGAACGAATTATCTGGCCCCTGG	SMAD7	ENSG00000101665	0.30435169530699513	[964,558]	[516,356]	3	hSpCas9	negative selection	342719
48921694	48921717	18	-	26472758	KBM7	viability	GTGCGGAGCAAAATCGGCTGCGG	SMAD7	ENSG00000101665	1.2468405820748103	[404,320]	[614,211]	9	hSpCas9	negative selection	342720
48921548	48921571	18	+	26472758	KBM7	viability	AAGCCTTGATGGAGAAACCGGGG	SMAD7	ENSG00000101665	-0.06489037927285923	[255,141]	[119,57]	0	hSpCas9	negative selection	342721
48921828	48921851	18	-	26472758	KBM7	viability	AGGAGAAGACGAGAGTGGGGAGG	SMAD7	ENSG00000101665	-0.0028803115977691363	[14,35]	[11,12]	0	hSpCas9	negative selection	342722
48921678	48921701	18	-	26472758	KBM7	viability	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	0.19471050279686752	[658,549]	[429,228]	2	hSpCas9	negative selection	342723
48921597	48921620	18	+	26472758	KBM7	viability	GGAGTCCGGGTTGTCCAGTGTGG	SMAD7	ENSG00000101665	-0.5123187932970255	[190,176]	[84,38]	-4	hSpCas9	negative selection	342724
48921516	48921539	18	-	26472758	KBM7	viability	AGAAGGCGTACAGCCTGCAGCGG	SMAD7	ENSG00000101665	0.4936192617614076	[246,226]	[128,181]	5	hSpCas9	negative selection	342725
48921483	48921506	18	-	26472758	KBM7	viability	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.2474464231778707	[354,255]	[186,151]	2	hSpCas9	negative selection	342726
48942514	48942537	18	-	26472758	Raji	viability	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	-0.5877618830979795	[135]	[20]	-5	hSpCas9	negative selection	533835
48921449	48921472	18	-	26472758	Raji	viability	CGTGCAGATCAGCTTTGTGAAGG	SMAD7	ENSG00000101665	0.047477783815609076	[712]	[170]	0	hSpCas9	negative selection	533836
48942492	48942515	18	-	26472758	Raji	viability	GGAACGAATTATCTGGCCCCTGG	SMAD7	ENSG00000101665	0.5493880822527126	[370]	[125]	5	hSpCas9	negative selection	533837
48921694	48921717	18	-	26472758	Raji	viability	GTGCGGAGCAAAATCGGCTGCGG	SMAD7	ENSG00000101665	0.8536269431278165	[154]	[64]	7	hSpCas9	negative selection	533838
48921548	48921571	18	+	26472758	Raji	viability	AAGCCTTGATGGAGAAACCGGGG	SMAD7	ENSG00000101665	1.8256125669582197	[61]	[50]	9	hSpCas9	negative selection	533839
48921828	48921851	18	-	26472758	Raji	viability	AGGAGAAGACGAGAGTGGGGAGG	SMAD7	ENSG00000101665	-1.352048083263698	[21]	[1]	-7	hSpCas9	negative selection	533840
48921678	48921701	18	-	26472758	Raji	viability	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	-0.6826933952521691	[331]	[47]	-5	hSpCas9	negative selection	533841
48921597	48921620	18	+	26472758	Raji	viability	GGAGTCCGGGTTGTCCAGTGTGG	SMAD7	ENSG00000101665	-0.322604305371216	[96]	[17]	-3	hSpCas9	negative selection	533842
48921516	48921539	18	-	26472758	Raji	viability	AGAAGGCGTACAGCCTGCAGCGG	SMAD7	ENSG00000101665	0.5224210346524434	[113]	[37]	5	hSpCas9	negative selection	533843
48921483	48921506	18	-	26472758	Raji	viability	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.5351320864019973	[112]	[37]	5	hSpCas9	negative selection	533844
48942514	48942537	18	-	26472758	K562	viability	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	-0.7392178261246658	[262]	[132]	-4	hSpCas9	negative selection	724953
48921449	48921472	18	-	26472758	K562	viability	CGTGCAGATCAGCTTTGTGAAGG	SMAD7	ENSG00000101665	0.3434985013744496	[843]	[903]	2	hSpCas9	negative selection	724954
48942492	48942515	18	-	26472758	K562	viability	GGAACGAATTATCTGGCCCCTGG	SMAD7	ENSG00000101665	-0.9550070068479741	[456]	[198]	-5	hSpCas9	negative selection	724955
48921694	48921717	18	-	26472758	K562	viability	GTGCGGAGCAAAATCGGCTGCGG	SMAD7	ENSG00000101665	0.6194581590133715	[255]	[331]	5	hSpCas9	negative selection	724956
48921548	48921571	18	+	26472758	K562	viability	AAGCCTTGATGGAGAAACCGGGG	SMAD7	ENSG00000101665	0.6229303509201769	[99]	[129]	5	hSpCas9	negative selection	724957
48921828	48921851	18	-	26472758	K562	viability	AGGAGAAGACGAGAGTGGGGAGG	SMAD7	ENSG00000101665	-1.308122295362332	[43]	[14]	-6	hSpCas9	negative selection	724958
48921678	48921701	18	-	26472758	K562	viability	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	1.0467603306846769	[452]	[789]	8	hSpCas9	negative selection	724959
48921597	48921620	18	+	26472758	K562	viability	GGAGTCCGGGTTGTCCAGTGTGG	SMAD7	ENSG00000101665	0.8585275740471194	[146]	[224]	7	hSpCas9	negative selection	724960
48921516	48921539	18	-	26472758	K562	viability	AGAAGGCGTACAGCCTGCAGCGG	SMAD7	ENSG00000101665	0.3824709089780006	[238]	[262]	3	hSpCas9	negative selection	724961
48921483	48921506	18	-	26472758	K562	viability	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	1.7669846912497358	[188]	[542]	9	hSpCas9	negative selection	724962
48921483	48921506	18	-	26627737	DLD1	viability	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.3252383795611937	[1742]	[634,731,682]	3	hSpCas9	negative selection	801626
48921677	48921700	18	-	26627737	DLD1	viability	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	-0.4556543564067427	[597]	[177,150,87]	-4	hSpCas9	negative selection	801627
48942514	48942537	18	-	26627737	DLD1	viability	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	-0.28106398755839934	[1482]	[442,353,350]	-3	hSpCas9	negative selection	801628
48948404	48948427	18	+	26627737	DLD1	viability	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	2.215693815581496	[172]	[197,195,342]	9	hSpCas9	negative selection	801629
48948406	48948429	18	+	26627737	DLD1	viability	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	1.0091968672032592	[637]	[499,497,235]	8	hSpCas9	negative selection	801630
48950213	48950236	18	-	26627737	DLD1	viability	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	1.6827011865444743	[199]	[218,214,172]	9	hSpCas9	negative selection	801631
48921483	48921506	18	-	26627737	GBM cells	viability after 5 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.4483693732171261	[616]	[426,475]	6	hSpCas9	negative selection	883941
48921677	48921700	18	-	26627737	GBM cells	viability after 5 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	-0.05290259160434928	[264]	[147,125]	-1	hSpCas9	negative selection	883942
48942514	48942537	18	-	26627737	GBM cells	viability after 5 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.3041203648048356	[588]	[411,367]	5	hSpCas9	negative selection	883943
48948404	48948427	18	+	26627737	GBM cells	viability after 5 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	0.09899171033459833	[241]	[105,171]	1	hSpCas9	negative selection	883944
48948406	48948429	18	+	26627737	GBM cells	viability after 5 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	-0.2006217986652289	[404]	[171,205]	-3	hSpCas9	negative selection	883945
48950213	48950236	18	-	26627737	GBM cells	viability after 5 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	0.6374727271275593	[180]	[168,132]	8	hSpCas9	negative selection	883946
48921483	48921506	18	-	26627737	GBM cells	viability after 13 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.6438261168638644	[616]	[591,466]	7	hSpCas9	negative selection	966256
48921677	48921700	18	-	26627737	GBM cells	viability after 13 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	0.0379041001695857	[264]	[124,165]	0	hSpCas9	negative selection	966257
48942514	48942537	18	-	26627737	GBM cells	viability after 13 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.28333291839810726	[588]	[378,396]	3	hSpCas9	negative selection	966258
48948404	48948427	18	+	26627737	GBM cells	viability after 13 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	0.5334862646678058	[241]	[226,159]	6	hSpCas9	negative selection	966259
48948406	48948429	18	+	26627737	GBM cells	viability after 13 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	-0.05400798775854698	[404]	[241,186]	0	hSpCas9	negative selection	966260
48950213	48950236	18	-	26627737	GBM cells	viability after 13 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	0.45954422549305035	[180]	[155,117]	6	hSpCas9	negative selection	966261
48921483	48921506	18	-	26627737	GBM cells	viability after 21 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.7989810158320836	[616]	[589,576]	7	hSpCas9	negative selection	1048571
48921677	48921700	18	-	26627737	GBM cells	viability after 21 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	0.17300270381964414	[264]	[154,168]	1	hSpCas9	negative selection	1048572
48942514	48942537	18	-	26627737	GBM cells	viability after 21 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.5823593943846375	[588]	[487,470]	6	hSpCas9	negative selection	1048573
48948404	48948427	18	+	26627737	GBM cells	viability after 21 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	0.7007381467225746	[241]	[220,206]	7	hSpCas9	negative selection	1048574
48948406	48948429	18	+	26627737	GBM cells	viability after 21 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	-0.1984202321848525	[404]	[220,164]	-2	hSpCas9	negative selection	1048575
48950213	48950236	18	-	26627737	GBM cells	viability after 21 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	0.6673301494704835	[180]	[163,148]	6	hSpCas9	negative selection	1048576
48921483	48921506	18	-	26627737	RPE1	viability after 9 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.5805793747602053	[2425]	[913,1421]	4	hSpCas9	negative selection	1130886
48921677	48921700	18	-	26627737	RPE1	viability after 9 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	0.30035500358490086	[901]	[252,469]	2	hSpCas9	negative selection	1130887
48942514	48942537	18	-	26627737	RPE1	viability after 9 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	-0.636057340530914	[2151]	[412,459]	-4	hSpCas9	negative selection	1130888
48948404	48948427	18	+	26627737	RPE1	viability after 9 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	1.8093166389991413	[196]	[168,276]	8	hSpCas9	negative selection	1130889
48948406	48948429	18	+	26627737	RPE1	viability after 9 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	-0.04529806131007019	[1358]	[317,533]	0	hSpCas9	negative selection	1130890
48950213	48950236	18	-	26627737	RPE1	viability after 9 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	0.6737842180962041	[317]	[191,115]	4	hSpCas9	negative selection	1130891
48921483	48921506	18	-	26627737	RPE1	viability after 12 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.8248892906784828	[2425]	[1241,1061]	5	hSpCas9	negative selection	1213201
48921677	48921700	18	-	26627737	RPE1	viability after 12 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	0.38316939818871565	[901]	[215,421]	2	hSpCas9	negative selection	1213202
48942514	48942537	18	-	26627737	RPE1	viability after 12 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	-0.17873623606812505	[2151]	[520,499]	-1	hSpCas9	negative selection	1213203
48948404	48948427	18	+	26627737	RPE1	viability after 12 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	1.4815620514755499	[196]	[174,118]	7	hSpCas9	negative selection	1213204
48948406	48948429	18	+	26627737	RPE1	viability after 12 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	0.0566606889720328	[1358]	[387,370]	0	hSpCas9	negative selection	1213205
48950213	48950236	18	-	26627737	RPE1	viability after 12 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	0.1509129656781032	[317]	[140,45]	1	hSpCas9	negative selection	1213206
48921483	48921506	18	-	26627737	RPE1	viability after 15 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.7188275858149797	[2425]	[989,1263]	4	hSpCas9	negative selection	1295516
48921677	48921700	18	-	26627737	RPE1	viability after 15 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	0.29789875459410786	[901]	[359,268]	2	hSpCas9	negative selection	1295517
48942514	48942537	18	-	26627737	RPE1	viability after 15 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	-0.4329470003448814	[2151]	[510,392]	-3	hSpCas9	negative selection	1295518
48948404	48948427	18	+	26627737	RPE1	viability after 15 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	1.1879961759779856	[196]	[156,97]	6	hSpCas9	negative selection	1295519
48948406	48948429	18	+	26627737	RPE1	viability after 15 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	0.07076587728325878	[1358]	[557,254]	0	hSpCas9	negative selection	1295520
48950213	48950236	18	-	26627737	RPE1	viability after 15 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	0.15432059029502776	[317]	[121,78]	1	hSpCas9	negative selection	1295521
48921483	48921506	18	-	26627737	RPE1	viability after 18 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.6268176016767777	[2425]	[936,1089]	4	hSpCas9	negative selection	1377831
48921677	48921700	18	-	26627737	RPE1	viability after 18 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	0.05802750442415691	[901]	[279,224]	0	hSpCas9	negative selection	1377832
48942514	48942537	18	-	26627737	RPE1	viability after 18 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	-0.5026642546398382	[2151]	[406,412]	-3	hSpCas9	negative selection	1377833
48948404	48948427	18	+	26627737	RPE1	viability after 18 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	0.81191253731417	[196]	[102,82]	5	hSpCas9	negative selection	1377834
48948406	48948429	18	+	26627737	RPE1	viability after 18 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	-0.17104535955031042	[1358]	[332,317]	-1	hSpCas9	negative selection	1377835
48950213	48950236	18	-	26627737	RPE1	viability after 18 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	0.34195551045723516	[317]	[174,37]	2	hSpCas9	negative selection	1377836
48921483	48921506	18	-	26627737	HeLa	viability after 8 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.4524533975842251	[900]	[774,321,562]	4	hSpCas9	negative selection	1460146
48921677	48921700	18	-	26627737	HeLa	viability after 8 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	0.2155336035252286	[554]	[95,221,468]	2	hSpCas9	negative selection	1460147
48942514	48942537	18	-	26627737	HeLa	viability after 8 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.04655127131491554	[702]	[468,307,211]	0	hSpCas9	negative selection	1460148
48948404	48948427	18	+	26627737	HeLa	viability after 8 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	0.01280988239554462	[335]	[233,130,99]	0	hSpCas9	negative selection	1460149
48948406	48948429	18	+	26627737	HeLa	viability after 8 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	-0.8406039168466274	[946]	[354,105,254]	-7	hSpCas9	negative selection	1460150
48950213	48950236	18	-	26627737	HeLa	viability after 8 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	-0.18111718703390278	[264]	[89,87,122]	-2	hSpCas9	negative selection	1460151
48921483	48921506	18	-	26627737	HeLa	viability after 12 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.5590853537583858	[900]	[386,860,359]	4	hSpCas9	negative selection	1542461
48921677	48921700	18	-	26627737	HeLa	viability after 12 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	-0.3033088364073697	[554]	[205,83,278]	-3	hSpCas9	negative selection	1542462
48942514	48942537	18	-	26627737	HeLa	viability after 12 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.31381553298130116	[702]	[493,249,354]	2	hSpCas9	negative selection	1542463
48948404	48948427	18	+	26627737	HeLa	viability after 12 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	-0.01344881322360389	[335]	[166,123,123]	0	hSpCas9	negative selection	1542464
48948406	48948429	18	+	26627737	HeLa	viability after 12 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	-0.15758144572059107	[946]	[701,131,251]	-1	hSpCas9	negative selection	1542465
48950213	48950236	18	-	26627737	HeLa	viability after 12 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	0.36669681029687023	[264]	[50,178,186]	3	hSpCas9	negative selection	1542466
48921483	48921506	18	-	26627737	HeLa	viability after 15 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.49030778172888945	[900]	[483,524,538]	4	hSpCas9	negative selection	1624776
48921677	48921700	18	-	26627737	HeLa	viability after 15 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	-1.1418418254508251	[554]	[65,134,106]	-7	hSpCas9	negative selection	1624777
48942514	48942537	18	-	26627737	HeLa	viability after 15 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	-0.0690467802720307	[702]	[317,297,195]	0	hSpCas9	negative selection	1624778
48948404	48948427	18	+	26627737	HeLa	viability after 15 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	0.6875115395523274	[335]	[237,161,263]	5	hSpCas9	negative selection	1624779
48948406	48948429	18	+	26627737	HeLa	viability after 15 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	-0.7721145142408974	[946]	[336,146,188]	-6	hSpCas9	negative selection	1624780
48950213	48950236	18	-	26627737	HeLa	viability after 15 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	-0.22976969464904884	[264]	[78,82,115]	-2	hSpCas9	negative selection	1624781
48921483	48921506	18	-	26627737	HeLa	viability after 18 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.5056009858144563	[900]	[335,433,538]	4	hSpCas9	negative selection	1707091
48921677	48921700	18	-	26627737	HeLa	viability after 18 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	-1.116785180852704	[554]	[45,113,106]	-7	hSpCas9	negative selection	1707092
48942514	48942537	18	-	26627737	HeLa	viability after 18 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	-0.022420470718679475	[702]	[220,258,195]	0	hSpCas9	negative selection	1707093
48948404	48948427	18	+	26627737	HeLa	viability after 18 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	0.684132638777005	[335]	[153,139,263]	5	hSpCas9	negative selection	1707094
48948406	48948429	18	+	26627737	HeLa	viability after 18 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	-0.7645512927612573	[946]	[228,120,188]	-6	hSpCas9	negative selection	1707095
48950213	48950236	18	-	26627737	HeLa	viability after 18 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	-0.213634407704673	[264]	[53,69,115]	-2	hSpCas9	negative selection	1707096
48921483	48921506	18	-	26627737	HCT116	viability after 6 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	1.0750677135474362	[1518]	[680,404]	6	hSpCas9	negative selection	1789406
48921677	48921700	18	-	26627737	HCT116	viability after 6 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	-0.9990590032215986	[1153]	[151,56]	-5	hSpCas9	negative selection	1789407
48942514	48942537	18	-	26627737	HCT116	viability after 6 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	-0.6463995607300583	[1156]	[228,53]	-4	hSpCas9	negative selection	1789408
48948404	48948427	18	+	26627737	HCT116	viability after 6 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	0.6679124033228881	[674]	[350,67]	3	hSpCas9	negative selection	1789409
48948406	48948429	18	+	26627737	HCT116	viability after 6 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	0.617046052746629	[751]	[413,52]	3	hSpCas9	negative selection	1789410
48950213	48950236	18	-	26627737	HCT116	viability after 6 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	0.19872725671695268	[344]	[49,68]	1	hSpCas9	negative selection	1789411
48921483	48921506	18	-	26627737	HCT116	viability after 8 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	-0.020278893972712986	[905]	[532,409,533]	0	hSpCas9	negative selection	1871721
48921677	48921700	18	-	26627737	HCT116	viability after 8 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	0.5316929106722141	[350]	[302,238,296]	5	hSpCas9	negative selection	1871722
48942514	48942537	18	-	26627737	HCT116	viability after 8 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.37531317687066634	[638]	[391,353,620]	4	hSpCas9	negative selection	1871723
48948404	48948427	18	+	26627737	HCT116	viability after 8 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	0.8781991861142939	[179]	[114,270,159]	7	hSpCas9	negative selection	1871724
48948406	48948429	18	+	26627737	HCT116	viability after 8 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	0.34952957864216494	[518]	[353,294,442]	4	hSpCas9	negative selection	1871725
48950213	48950236	18	-	26627737	HCT116	viability after 8 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	0.3854112508697086	[193]	[115,122,178]	4	hSpCas9	negative selection	1871726
48921483	48921506	18	-	26627737	HCT116	viability after 9 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.8470170731002271	[1518]	[785,684]	6	hSpCas9	negative selection	1954036
48921677	48921700	18	-	26627737	HCT116	viability after 9 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	-0.076456312719694	[1153]	[165,391]	0	hSpCas9	negative selection	1954037
48942514	48942537	18	-	26627737	HCT116	viability after 9 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.31628167017030484	[1156]	[301,449]	2	hSpCas9	negative selection	1954038
48948404	48948427	18	+	26627737	HCT116	viability after 9 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	0.27972692775840835	[674]	[358,107]	2	hSpCas9	negative selection	1954039
48948406	48948429	18	+	26627737	HCT116	viability after 9 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	0.13518315884873616	[751]	[205,231]	1	hSpCas9	negative selection	1954040
48950213	48950236	18	-	26627737	HCT116	viability after 9 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	-0.41920044791881095	[344]	[150,3]	-3	hSpCas9	negative selection	1954041
48921483	48921506	18	-	26627737	HCT116	viability after 12 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.3192995784106596	[905]	[518,683,587]	3	hSpCas9	negative selection	2036351
48921677	48921700	18	-	26627737	HCT116	viability after 12 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	0.6309590366053779	[350]	[400,168,273]	6	hSpCas9	negative selection	2036352
48942514	48942537	18	-	26627737	HCT116	viability after 12 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.20740458916849303	[638]	[249,581,347]	2	hSpCas9	negative selection	2036353
48948404	48948427	18	+	26627737	HCT116	viability after 12 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	1.0208791233351728	[179]	[131,269,180]	8	hSpCas9	negative selection	2036354
48948406	48948429	18	+	26627737	HCT116	viability after 12 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	0.2824846609284083	[518]	[375,317,296]	3	hSpCas9	negative selection	2036355
48950213	48950236	18	-	26627737	HCT116	viability after 12 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	0.9454613436070489	[193]	[227,103,251]	7	hSpCas9	negative selection	2036356
48921483	48921506	18	-	26627737	HCT116	viability after 15 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.35150202012135834	[905]	[451,783,728]	3	hSpCas9	negative selection	2118666
48921677	48921700	18	-	26627737	HCT116	viability after 15 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	0.743535218056473	[350]	[549,287,201]	6	hSpCas9	negative selection	2118667
48942514	48942537	18	-	26627737	HCT116	viability after 15 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.2506960062537724	[638]	[186,449,639]	2	hSpCas9	negative selection	2118668
48948404	48948427	18	+	26627737	HCT116	viability after 15 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	1.234867360934418	[179]	[183,238,298]	8	hSpCas9	negative selection	2118669
48948406	48948429	18	+	26627737	HCT116	viability after 15 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	0.47932358583363277	[518]	[484,269,498]	4	hSpCas9	negative selection	2118670
48950213	48950236	18	-	26627737	HCT116	viability after 15 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	0.5716425868969484	[193]	[230,131,141]	5	hSpCas9	negative selection	2118671
48921483	48921506	18	-	26627737	HCT116	viability after 18 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.4042790981567612	[905]	[447,513,790]	3	hSpCas9	negative selection	2200981
48921677	48921700	18	-	26627737	HCT116	viability after 18 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	0.8144195073532732	[350]	[254,326,311]	6	hSpCas9	negative selection	2200982
48942514	48942537	18	-	26627737	HCT116	viability after 18 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.1362649902675912	[638]	[93,470,449]	1	hSpCas9	negative selection	2200983
48948404	48948427	18	+	26627737	HCT116	viability after 18 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	1.4045561685612233	[179]	[174,219,299]	8	hSpCas9	negative selection	2200984
48948406	48948429	18	+	26627737	HCT116	viability after 18 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	0.11363223302525172	[518]	[183,310,318]	1	hSpCas9	negative selection	2200985
48950213	48950236	18	-	26627737	HCT116	viability after 18 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	0.9907083710368618	[193]	[146,254,150]	7	hSpCas9	negative selection	2200986
48921740	48921763	18	+	24336569	HL60	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	-0.03644017594290072	[1040]	[2147]	0	hSpCas9	negative selection	2295693
48921775	48921798	18	-	24336569	HL60	viability	ATCTTCTATGATCTACCTCAGGG	SMAD7	ENSG00000101665	0.06292580870627862	[246]	[545]	0	hSpCas9	negative selection	2295694
48921786	48921809	18	+	24336569	HL60	viability	ATCATAGAAGATATCCAGAGAGG	SMAD7	ENSG00000101665	-0.2886701181506681	[440]	[763]	-3	hSpCas9	negative selection	2295695
48921800	48921823	18	-	24336569	HL60	viability	CTGTGTCCAGGAGCCCTCTCTGG	SMAD7	ENSG00000101665	-0.467742606926316	[148]	[227]	-4	hSpCas9	negative selection	2295696
48921832	48921855	18	-	24336569	HL60	viability	TGGGAGGAGAAGACGAGAGTGGG	SMAD7	ENSG00000101665	-0.1463215839460088	[1307]	[2500]	-1	hSpCas9	negative selection	2295697
48921848	48921871	18	-	24336569	HL60	viability	GTGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	-0.0668629362687001	[638]	[1290]	0	hSpCas9	negative selection	2295698
48921860	48921883	18	-	24336569	HL60	viability	TCGGTCACACTGGTGCGTGGTGG	SMAD7	ENSG00000101665	-0.0021375049053102835	[1432]	[3027]	0	hSpCas9	negative selection	2295699
48921885	48921908	18	-	24336569	HL60	viability	CCCAACTTCTTCTGGAGCCTGGG	SMAD7	ENSG00000101665	0.5494987053040462	[534]	[1656]	5	hSpCas9	negative selection	2295700
48942515	48942538	18	-	24336569	HL60	viability	TGCCTTCCTCCGCTGAAACAGGG	SMAD7	ENSG00000101665	0.24458010273069783	[559]	[1403]	2	hSpCas9	negative selection	2295701
48942525	48942548	18	+	24336569	HL60	viability	GCGGAGGAAGGCACAGCATCTGG	SMAD7	ENSG00000101665	0.7999811059777109	[918]	[3385]	6	hSpCas9	negative selection	2295702
48921740	48921763	18	+	24336569	KBM7	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.9692252289041492	[458]	[2450]	8	hSpCas9	negative selection	2362870
48921775	48921798	18	-	24336569	KBM7	viability	ATCTTCTATGATCTACCTCAGGG	SMAD7	ENSG00000101665	-0.7823493559815909	[267]	[424]	-5	hSpCas9	negative selection	2362871
48921786	48921809	18	+	24336569	KBM7	viability	ATCATAGAAGATATCCAGAGAGG	SMAD7	ENSG00000101665	0.14350940696911518	[234]	[707]	1	hSpCas9	negative selection	2362872
48921800	48921823	18	-	24336569	KBM7	viability	CTGTGTCCAGGAGCCCTCTCTGG	SMAD7	ENSG00000101665	-0.27004101099669464	[41]	[94]	-2	hSpCas9	negative selection	2362873
48921832	48921855	18	-	24336569	KBM7	viability	TGGGAGGAGAAGACGAGAGTGGG	SMAD7	ENSG00000101665	0.0627847144128304	[1269]	[3617]	0	hSpCas9	negative selection	2362874
48921848	48921871	18	-	24336569	KBM7	viability	GTGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	0.9447382262298778	[351]	[1847]	7	hSpCas9	negative selection	2362875
48921860	48921883	18	-	24336569	KBM7	viability	TCGGTCACACTGGTGCGTGGTGG	SMAD7	ENSG00000101665	0.12692894653510733	[830]	[2474]	1	hSpCas9	negative selection	2362876
48921885	48921908	18	-	24336569	KBM7	viability	CCCAACTTCTTCTGGAGCCTGGG	SMAD7	ENSG00000101665	0.32395954616474976	[535]	[1829]	3	hSpCas9	negative selection	2362877
48942515	48942538	18	-	24336569	KBM7	viability	TGCCTTCCTCCGCTGAAACAGGG	SMAD7	ENSG00000101665	0.6637819123988213	[323]	[1399]	6	hSpCas9	negative selection	2362878
48942525	48942548	18	+	24336569	KBM7	viability	GCGGAGGAAGGCACAGCATCTGG	SMAD7	ENSG00000101665	-0.15581307217177265	[840]	[2058]	-1	hSpCas9	negative selection	2362879
48949510	48949533	18	+	25494202	A375	resistance to PLX-4720 (puromycin)	AATTTTTAACCGCAGACTGCAGG	SMAD7	ENSG00000101665	-0.8207059771409193	[336,280]	[27,48]	-4	dCas9-VP64	positive selection	2408747
48949419	48949442	18	-	25494202	A375	resistance to PLX-4720 (puromycin)	CGGAAAGACGTTGAGGTGTGTGG	SMAD7	ENSG00000101665	0.9988067308963715	[43,39]	[27,7]	4	dCas9-VP64	positive selection	2408748
48949480	48949503	18	-	25494202	A375	resistance to PLX-4720 (puromycin)	TTCATTTCCGGATCAACAAGGGG	SMAD7	ENSG00000101665	-0.8100264900322318	[145,87]	[22,4]	-4	dCas9-VP64	positive selection	2408749
48942971	48942994	18	-	25494202	A375	resistance to PLX-4720 (puromycin)	CTGGGAAACCTGTCTTTAAAAGG	SMAD7	ENSG00000101665	-1.0632512435168477	[40,99]	[4,8]	-6	dCas9-VP64	positive selection	2408750
48942949	48942972	18	-	25494202	A375	resistance to PLX-4720 (puromycin)	GATGAAGGCAGAGAGGACATGGG	SMAD7	ENSG00000101665	0.2887082477941927	[357,82]	[26,92]	1	dCas9-VP64	positive selection	2408751
48942898	48942921	18	-	25494202	A375	resistance to PLX-4720 (puromycin)	TGAGGGATGACAGAGCAACCAGG	SMAD7	ENSG00000101665	1.5076049387888348	[115,41]	[14,84]	5	dCas9-VP64	positive selection	2408752
48949510	48949533	18	+	25494202	A375	resistance to PLX-4720 (zeocin)	AATTTTTAACCGCAGACTGCAGG	SMAD7	ENSG00000101665	0.2267928987430341	[110,454]	[48,160]	1	dCas9-VP64	positive selection	2504002
48949419	48949442	18	-	25494202	A375	resistance to PLX-4720 (zeocin)	CGGAAAGACGTTGAGGTGTGTGG	SMAD7	ENSG00000101665	-1.2219742141420953	[76,169]	[13,18]	-9	dCas9-VP64	positive selection	2504003
48949480	48949503	18	-	25494202	A375	resistance to PLX-4720 (zeocin)	TTCATTTCCGGATCAACAAGGGG	SMAD7	ENSG00000101665	0.06939804863854371	[121,230]	[33,83]	0	dCas9-VP64	positive selection	2504004
48942971	48942994	18	-	25494202	A375	resistance to PLX-4720 (zeocin)	CTGGGAAACCTGTCTTTAAAAGG	SMAD7	ENSG00000101665	-0.367957859504312	[61,173]	[28,29]	-4	dCas9-VP64	positive selection	2504005
48942949	48942972	18	-	25494202	A375	resistance to PLX-4720 (zeocin)	GATGAAGGCAGAGAGGACATGGG	SMAD7	ENSG00000101665	1.0759386568852929	[371,314]	[171,297]	7	dCas9-VP64	positive selection	2504006
48942898	48942921	18	-	25494202	A375	resistance to PLX-4720 (zeocin)	TGAGGGATGACAGAGCAACCAGG	SMAD7	ENSG00000101665	-0.058231531266869974	[54,28]	[10,14]	0	dCas9-VP64	positive selection	2504007
48921775	48921798	18	-	27260157	DLD1	viability	ATCTTCTATGATCTACCTCAGGG	SMAD7	ENSG00000101665	-1.07452562643937	[]	[]	-7	hSpCas9	negative selection	2573747
48950380	48950403	18	-	27260157	DLD1	viability	CGCTCGTCCGGCGTCTCTGGAGG	SMAD7	ENSG00000101665	-1.20369726321011	[]	[]	-7	hSpCas9	negative selection	2577771
48949907	48949930	18	+	27260157	DLD1	viability	TCCGAGGAATGCCTGAGATCCGG	SMAD7	ENSG00000101665	0.0826273316041512	[]	[]	3	hSpCas9	negative selection	2580581
48921885	48921908	18	-	27260157	DLD1	viability	CCCAACTTCTTCTGGAGCCTGGG	SMAD7	ENSG00000101665	0.967746772468898	[]	[]	9	hSpCas9	negative selection	2585076
48921740	48921763	18	+	27260157	DLD1	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	-1.67592519856926	[]	[]	-8	hSpCas9	negative selection	2604110
48949897	48949920	18	-	27260157	DLD1	viability	GGCATTCCTCGGAAGTCAAGAGG	SMAD7	ENSG00000101665	-0.526261245954806	[]	[]	-4	hSpCas9	negative selection	2607714
48942515	48942538	18	-	27260157	DLD1	viability	TGCCTTCCTCCGCTGAAACAGGG	SMAD7	ENSG00000101665	-0.92762052450981	[]	[]	-6	hSpCas9	negative selection	2607833
48950392	48950415	18	+	27260157	DLD1	viability	CCGGACGAGCGCAGATCGTTTGG	SMAD7	ENSG00000101665	0.180527236342228	[]	[]	3	hSpCas9	negative selection	2608146
48950036	48950059	18	-	27260157	DLD1	viability	ACCGCGTGCCTCCTGCTGCCCGG	SMAD7	ENSG00000101665	0.262536191828417	[]	[]	4	hSpCas9	negative selection	2609875
48950392	48950415	18	-	27260157	DLD1	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	-0.492247659091192	[]	[]	-4	hSpCas9	negative selection	2610587
48921848	48921871	18	-	27260157	DLD1	viability	GTGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	-0.971996118518331	[]	[]	-7	hSpCas9	negative selection	2613829
48950140	48950163	18	+	27260157	DLD1	viability	GAGCGCCTTCAGATCCGCCTCGG	SMAD7	ENSG00000101665	-0.545568094347508	[]	[]	-4	hSpCas9	negative selection	2616013
48921786	48921809	18	+	27260157	DLD1	viability	ATCATAGAAGATATCCAGAGAGG	SMAD7	ENSG00000101665	-1.5507293424059	[]	[]	-8	hSpCas9	negative selection	2617021
48921860	48921883	18	-	27260157	DLD1	viability	TCGGTCACACTGGTGCGTGGTGG	SMAD7	ENSG00000101665	-2.67549774220472	[]	[]	-9	hSpCas9	negative selection	2619797
48942525	48942548	18	+	27260157	DLD1	viability	GCGGAGGAAGGCACAGCATCTGG	SMAD7	ENSG00000101665	0.840865365417292	[]	[]	9	hSpCas9	negative selection	2620414
48921800	48921823	18	-	27260157	DLD1	viability	CTGTGTCCAGGAGCCCTCTCTGG	SMAD7	ENSG00000101665	-1.15442221846151	[]	[]	-7	hSpCas9	negative selection	2620433
48950277	48950300	18	-	27260157	DLD1	viability	GACGGACAGCCGAGCGCATGGGG	SMAD7	ENSG00000101665	0.645225913736389	[]	[]	8	hSpCas9	negative selection	2621395
48949908	48949931	18	-	27260157	DLD1	viability	GCCGGATCTCAGGCATTCCTCGG	SMAD7	ENSG00000101665	-0.955893283646887	[]	[]	-7	hSpCas9	negative selection	2645830
48950213	48950236	18	-	27260157	DLD1	viability	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	0.170594130344587	[]	[]	3	hSpCas9	negative selection	2647522
48921775	48921798	18	-	27260157	HT1080	viability	ATCTTCTATGATCTACCTCAGGG	SMAD7	ENSG00000101665	-0.833712694876316	[]	[]	-8	hSpCas9	negative selection	2649877
48950380	48950403	18	-	27260157	HT1080	viability	CGCTCGTCCGGCGTCTCTGGAGG	SMAD7	ENSG00000101665	-2.14007675796556	[]	[]	-9	hSpCas9	negative selection	2653901
48949907	48949930	18	+	27260157	HT1080	viability	TCCGAGGAATGCCTGAGATCCGG	SMAD7	ENSG00000101665	-0.40873265715876	[]	[]	-7	hSpCas9	negative selection	2656711
48921885	48921908	18	-	27260157	HT1080	viability	CCCAACTTCTTCTGGAGCCTGGG	SMAD7	ENSG00000101665	1.73318873628357	[]	[]	9	hSpCas9	negative selection	2661206
48921740	48921763	18	+	27260157	HT1080	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.00284978948615386	[]	[]	0	hSpCas9	negative selection	2680240
48949897	48949920	18	-	27260157	HT1080	viability	GGCATTCCTCGGAAGTCAAGAGG	SMAD7	ENSG00000101665	-0.0485787352424153	[]	[]	0	hSpCas9	negative selection	2683844
48942515	48942538	18	-	27260157	HT1080	viability	TGCCTTCCTCCGCTGAAACAGGG	SMAD7	ENSG00000101665	0.670427027304653	[]	[]	6	hSpCas9	negative selection	2683963
48950392	48950415	18	+	27260157	HT1080	viability	CCGGACGAGCGCAGATCGTTTGG	SMAD7	ENSG00000101665	0.665842954096922	[]	[]	6	hSpCas9	negative selection	2684276
48950036	48950059	18	-	27260157	HT1080	viability	ACCGCGTGCCTCCTGCTGCCCGG	SMAD7	ENSG00000101665	1.20361828606086	[]	[]	8	hSpCas9	negative selection	2686005
48950392	48950415	18	-	27260157	HT1080	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	-1.05200994443862	[]	[]	-8	hSpCas9	negative selection	2686717
48921848	48921871	18	-	27260157	HT1080	viability	GTGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	-0.204807548174917	[]	[]	0	hSpCas9	negative selection	2689959
48950140	48950163	18	+	27260157	HT1080	viability	GAGCGCCTTCAGATCCGCCTCGG	SMAD7	ENSG00000101665	0.378010255313527	[]	[]	3	hSpCas9	negative selection	2692143
48921786	48921809	18	+	27260157	HT1080	viability	ATCATAGAAGATATCCAGAGAGG	SMAD7	ENSG00000101665	0.280931935399519	[]	[]	2	hSpCas9	negative selection	2693151
48921860	48921883	18	-	27260157	HT1080	viability	TCGGTCACACTGGTGCGTGGTGG	SMAD7	ENSG00000101665	-2.01168460932173	[]	[]	-9	hSpCas9	negative selection	2695927
48942525	48942548	18	+	27260157	HT1080	viability	GCGGAGGAAGGCACAGCATCTGG	SMAD7	ENSG00000101665	1.08494521741118	[]	[]	8	hSpCas9	negative selection	2696544
48921800	48921823	18	-	27260157	HT1080	viability	CTGTGTCCAGGAGCCCTCTCTGG	SMAD7	ENSG00000101665	-0.364457718934781	[]	[]	-7	hSpCas9	negative selection	2696563
48950277	48950300	18	-	27260157	HT1080	viability	GACGGACAGCCGAGCGCATGGGG	SMAD7	ENSG00000101665	0.944983805638052	[]	[]	7	hSpCas9	negative selection	2697525
48949908	48949931	18	-	27260157	HT1080	viability	GCCGGATCTCAGGCATTCCTCGG	SMAD7	ENSG00000101665	-0.510137590322993	[]	[]	-7	hSpCas9	negative selection	2721960
48950213	48950236	18	-	27260157	HT1080	viability	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	0.163638702145656	[]	[]	1	hSpCas9	negative selection	2723652
48921775	48921798	18	-	27260157	MKN45	viability	ATCTTCTATGATCTACCTCAGGG	SMAD7	ENSG00000101665	-0.925196994893293	[]	[]	-7	hSpCas9	negative selection	2726007
48950380	48950403	18	-	27260157	MKN45	viability	CGCTCGTCCGGCGTCTCTGGAGG	SMAD7	ENSG00000101665	-1.28556889245274	[]	[]	-8	hSpCas9	negative selection	2730031
48949907	48949930	18	+	27260157	MKN45	viability	TCCGAGGAATGCCTGAGATCCGG	SMAD7	ENSG00000101665	1.30776939276073	[]	[]	9	hSpCas9	negative selection	2732841
48921885	48921908	18	-	27260157	MKN45	viability	CCCAACTTCTTCTGGAGCCTGGG	SMAD7	ENSG00000101665	1.51341681227938	[]	[]	9	hSpCas9	negative selection	2737336
48921740	48921763	18	+	27260157	MKN45	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.853241719645078	[]	[]	8	hSpCas9	negative selection	2756370
48949897	48949920	18	-	27260157	MKN45	viability	GGCATTCCTCGGAAGTCAAGAGG	SMAD7	ENSG00000101665	0.500097687513352	[]	[]	6	hSpCas9	negative selection	2759974
48942515	48942538	18	-	27260157	MKN45	viability	TGCCTTCCTCCGCTGAAACAGGG	SMAD7	ENSG00000101665	1.12671016246493	[]	[]	8	hSpCas9	negative selection	2760093
48950392	48950415	18	+	27260157	MKN45	viability	CCGGACGAGCGCAGATCGTTTGG	SMAD7	ENSG00000101665	-0.489463413152365	[]	[]	-6	hSpCas9	negative selection	2760406
48950036	48950059	18	-	27260157	MKN45	viability	ACCGCGTGCCTCCTGCTGCCCGG	SMAD7	ENSG00000101665	1.52065628895227	[]	[]	9	hSpCas9	negative selection	2762135
48950392	48950415	18	-	27260157	MKN45	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.196011335961551	[]	[]	5	hSpCas9	negative selection	2762847
48921848	48921871	18	-	27260157	MKN45	viability	GTGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	0.186507298900936	[]	[]	5	hSpCas9	negative selection	2766089
48950140	48950163	18	+	27260157	MKN45	viability	GAGCGCCTTCAGATCCGCCTCGG	SMAD7	ENSG00000101665	0.9522983877294	[]	[]	8	hSpCas9	negative selection	2768273
48921786	48921809	18	+	27260157	MKN45	viability	ATCATAGAAGATATCCAGAGAGG	SMAD7	ENSG00000101665	1.22887523577813	[]	[]	9	hSpCas9	negative selection	2769281
48921860	48921883	18	-	27260157	MKN45	viability	TCGGTCACACTGGTGCGTGGTGG	SMAD7	ENSG00000101665	-0.963387749316861	[]	[]	-7	hSpCas9	negative selection	2772057
48942525	48942548	18	+	27260157	MKN45	viability	GCGGAGGAAGGCACAGCATCTGG	SMAD7	ENSG00000101665	1.10077851190152	[]	[]	8	hSpCas9	negative selection	2772674
48921800	48921823	18	-	27260157	MKN45	viability	CTGTGTCCAGGAGCCCTCTCTGG	SMAD7	ENSG00000101665	0.809503904209697	[]	[]	8	hSpCas9	negative selection	2772693
48950277	48950300	18	-	27260157	MKN45	viability	GACGGACAGCCGAGCGCATGGGG	SMAD7	ENSG00000101665	1.13767484768382	[]	[]	8	hSpCas9	negative selection	2773655
48949908	48949931	18	-	27260157	MKN45	viability	GCCGGATCTCAGGCATTCCTCGG	SMAD7	ENSG00000101665	-0.608727978324395	[]	[]	-6	hSpCas9	negative selection	2798090
48950213	48950236	18	-	27260157	MKN45	viability	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	1.23580690588398	[]	[]	9	hSpCas9	negative selection	2799782
48921775	48921798	18	-	27260157	RKO	viability	ATCTTCTATGATCTACCTCAGGG	SMAD7	ENSG00000101665	-0.379114903598019	[]	[]	-6	hSpCas9	negative selection	2802137
48950380	48950403	18	-	27260157	RKO	viability	CGCTCGTCCGGCGTCTCTGGAGG	SMAD7	ENSG00000101665	-1.35843221785713	[]	[]	-8	hSpCas9	negative selection	2806161
48949907	48949930	18	+	27260157	RKO	viability	TCCGAGGAATGCCTGAGATCCGG	SMAD7	ENSG00000101665	0.0733455545926616	[]	[]	0	hSpCas9	negative selection	2808971
48921885	48921908	18	-	27260157	RKO	viability	CCCAACTTCTTCTGGAGCCTGGG	SMAD7	ENSG00000101665	0.922901218987909	[]	[]	8	hSpCas9	negative selection	2813466
48921740	48921763	18	+	27260157	RKO	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.199986135062811	[]	[]	1	hSpCas9	negative selection	2832500
48949897	48949920	18	-	27260157	RKO	viability	GGCATTCCTCGGAAGTCAAGAGG	SMAD7	ENSG00000101665	-0.12465276836725	[]	[]	0	hSpCas9	negative selection	2836104
48942515	48942538	18	-	27260157	RKO	viability	TGCCTTCCTCCGCTGAAACAGGG	SMAD7	ENSG00000101665	1.05897732952612	[]	[]	9	hSpCas9	negative selection	2836223
48950392	48950415	18	+	27260157	RKO	viability	CCGGACGAGCGCAGATCGTTTGG	SMAD7	ENSG00000101665	0.0129380066097918	[]	[]	0	hSpCas9	negative selection	2836536
48950036	48950059	18	-	27260157	RKO	viability	ACCGCGTGCCTCCTGCTGCCCGG	SMAD7	ENSG00000101665	-0.0277045921991301	[]	[]	0	hSpCas9	negative selection	2838265
48950392	48950415	18	-	27260157	RKO	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	-0.0732097455814698	[]	[]	0	hSpCas9	negative selection	2838977
48921848	48921871	18	-	27260157	RKO	viability	GTGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	-1.48081564234301	[]	[]	-8	hSpCas9	negative selection	2842219
48950140	48950163	18	+	27260157	RKO	viability	GAGCGCCTTCAGATCCGCCTCGG	SMAD7	ENSG00000101665	0.710445233502418	[]	[]	8	hSpCas9	negative selection	2844403
48921786	48921809	18	+	27260157	RKO	viability	ATCATAGAAGATATCCAGAGAGG	SMAD7	ENSG00000101665	0.602235168969587	[]	[]	3	hSpCas9	negative selection	2845411
48921860	48921883	18	-	27260157	RKO	viability	TCGGTCACACTGGTGCGTGGTGG	SMAD7	ENSG00000101665	-1.85097080953021	[]	[]	-9	hSpCas9	negative selection	2848187
48942525	48942548	18	+	27260157	RKO	viability	GCGGAGGAAGGCACAGCATCTGG	SMAD7	ENSG00000101665	1.43544256393649	[]	[]	9	hSpCas9	negative selection	2848804
48921800	48921823	18	-	27260157	RKO	viability	CTGTGTCCAGGAGCCCTCTCTGG	SMAD7	ENSG00000101665	0.384014195350823	[]	[]	2	hSpCas9	negative selection	2848823
48950277	48950300	18	-	27260157	RKO	viability	GACGGACAGCCGAGCGCATGGGG	SMAD7	ENSG00000101665	0.0846904957459639	[]	[]	0	hSpCas9	negative selection	2849785
48949908	48949931	18	-	27260157	RKO	viability	GCCGGATCTCAGGCATTCCTCGG	SMAD7	ENSG00000101665	-0.0376988464602828	[]	[]	0	hSpCas9	negative selection	2874220
48950213	48950236	18	-	27260157	RKO	viability	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	-0.262086649769874	[]	[]	-1	hSpCas9	negative selection	2875912
48921775	48921798	18	-	27260157	SF268	viability	ATCTTCTATGATCTACCTCAGGG	SMAD7	ENSG00000101665	-0.478092654959581	[]	[]	-4	hSpCas9	negative selection	2878267
48950380	48950403	18	-	27260157	SF268	viability	CGCTCGTCCGGCGTCTCTGGAGG	SMAD7	ENSG00000101665	-0.877501520433117	[]	[]	-6	hSpCas9	negative selection	2882291
48949907	48949930	18	+	27260157	SF268	viability	TCCGAGGAATGCCTGAGATCCGG	SMAD7	ENSG00000101665	0.584403668604217	[]	[]	8	hSpCas9	negative selection	2885101
48921885	48921908	18	-	27260157	SF268	viability	CCCAACTTCTTCTGGAGCCTGGG	SMAD7	ENSG00000101665	0.880114096631694	[]	[]	9	hSpCas9	negative selection	2889596
48921740	48921763	18	+	27260157	SF268	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.13491850459582	[]	[]	0	hSpCas9	negative selection	2908630
48949897	48949920	18	-	27260157	SF268	viability	GGCATTCCTCGGAAGTCAAGAGG	SMAD7	ENSG00000101665	0.661371053144383	[]	[]	8	hSpCas9	negative selection	2912234
48942515	48942538	18	-	27260157	SF268	viability	TGCCTTCCTCCGCTGAAACAGGG	SMAD7	ENSG00000101665	1.05391564464023	[]	[]	9	hSpCas9	negative selection	2912353
48950392	48950415	18	+	27260157	SF268	viability	CCGGACGAGCGCAGATCGTTTGG	SMAD7	ENSG00000101665	-0.0445675681374904	[]	[]	0	hSpCas9	negative selection	2912666
48950036	48950059	18	-	27260157	SF268	viability	ACCGCGTGCCTCCTGCTGCCCGG	SMAD7	ENSG00000101665	0.764004891958686	[]	[]	8	hSpCas9	negative selection	2914395
48950392	48950415	18	-	27260157	SF268	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.369844561477737	[]	[]	4	hSpCas9	negative selection	2915107
48921848	48921871	18	-	27260157	SF268	viability	GTGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	-0.451943284773689	[]	[]	-4	hSpCas9	negative selection	2918349
48950140	48950163	18	+	27260157	SF268	viability	GAGCGCCTTCAGATCCGCCTCGG	SMAD7	ENSG00000101665	0.889130684925223	[]	[]	9	hSpCas9	negative selection	2920533
48921786	48921809	18	+	27260157	SF268	viability	ATCATAGAAGATATCCAGAGAGG	SMAD7	ENSG00000101665	0.342284866552711	[]	[]	4	hSpCas9	negative selection	2921541
48921860	48921883	18	-	27260157	SF268	viability	TCGGTCACACTGGTGCGTGGTGG	SMAD7	ENSG00000101665	-1.62445777761018	[]	[]	-8	hSpCas9	negative selection	2924317
48942525	48942548	18	+	27260157	SF268	viability	GCGGAGGAAGGCACAGCATCTGG	SMAD7	ENSG00000101665	0.924002360092788	[]	[]	9	hSpCas9	negative selection	2924934
48921800	48921823	18	-	27260157	SF268	viability	CTGTGTCCAGGAGCCCTCTCTGG	SMAD7	ENSG00000101665	0.295834516801773	[]	[]	4	hSpCas9	negative selection	2924953
48950277	48950300	18	-	27260157	SF268	viability	GACGGACAGCCGAGCGCATGGGG	SMAD7	ENSG00000101665	1.64822699309649	[]	[]	9	hSpCas9	negative selection	2925915
48949908	48949931	18	-	27260157	SF268	viability	GCCGGATCTCAGGCATTCCTCGG	SMAD7	ENSG00000101665	0.264172558452457	[]	[]	4	hSpCas9	negative selection	2950350
48950213	48950236	18	-	27260157	SF268	viability	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	-0.314928072741464	[]	[]	-2	hSpCas9	negative selection	2952042
48942474	48942497	18	+	27013184	SW480	treatment with recombinant TRAIL	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.41465695739601993	[218,284]	[205,53]	2	hSpCas9	positive selection	2956301
48948368	48948391	18	+	27013184	SW480	treatment with recombinant TRAIL	AAAATCATCTACTCACCAGTTGG	SMAD7	ENSG00000101665	-1.3337184524093386	[246,504]	[61,62]	-6	hSpCas9	positive selection	2956302
48948386	48948409	18	+	27013184	SW480	treatment with recombinant TRAIL	GTTGGTTTGAGAAAATCCATCGG	SMAD7	ENSG00000101665	-4.570404260541373	[212,178]	[3,2]	-9	hSpCas9	positive selection	2956303
48949841	48949864	18	+	27013184	SW480	treatment with recombinant TRAIL	GGGTTGCAGCACACCAGCTCGGG	SMAD7	ENSG00000101665	-0.4960388823315425	[58,110]	[21,29]	-2	hSpCas9	positive selection	2956304
48949842	48949865	18	+	27013184	SW480	treatment with recombinant TRAIL	GGTTGCAGCACACCAGCTCGGGG	SMAD7	ENSG00000101665	0.5671226080876604	[258,198]	[150,143]	3	hSpCas9	positive selection	2956305
48949891	48949914	18	+	27013184	SW480	treatment with recombinant TRAIL	ACACAGCCTCTTGACTTCCGAGG	SMAD7	ENSG00000101665	1.1477836983690715	[383,504]	[345,524]	5	hSpCas9	positive selection	2956306
48949907	48949930	18	+	27013184	SW480	treatment with recombinant TRAIL	TCCGAGGAATGCCTGAGATCCGG	SMAD7	ENSG00000101665	1.6361056175678304	[252,182]	[251,359]	7	hSpCas9	positive selection	2956307
48949932	48949955	18	+	27013184	SW480	treatment with recombinant TRAIL	ACCTGAACACTTTGCACAGCAGG	SMAD7	ENSG00000101665	-1.20964801609489	[141,194]	[4,67]	-5	hSpCas9	positive selection	2956308
48949935	48949958	18	+	27013184	SW480	treatment with recombinant TRAIL	TGAACACTTTGCACAGCAGGAGG	SMAD7	ENSG00000101665	-0.08376160921965875	[179,139]	[43,96]	0	hSpCas9	positive selection	2956310
48949936	48949959	18	+	27013184	SW480	treatment with recombinant TRAIL	GAACACTTTGCACAGCAGGAGGG	SMAD7	ENSG00000101665	-1.2647599564919287	[109,99]	[20,15]	-5	hSpCas9	positive selection	2956311
48949937	48949960	18	+	27013184	SW480	treatment with recombinant TRAIL	AACACTTTGCACAGCAGGAGGGG	SMAD7	ENSG00000101665	-3.3144549961439487	[77,7]	[1,1]	-9	hSpCas9	positive selection	2956312
48949938	48949961	18	+	27013184	SW480	treatment with recombinant TRAIL	ACACTTTGCACAGCAGGAGGGGG	SMAD7	ENSG00000101665	-0.6815624040917225	[227,197]	[22,106]	-3	hSpCas9	positive selection	2956313
48948387	48948410	18	+	27013184	SW480	treatment with recombinant TRAIL	TTGGTTTGAGAAAATCCATCGGG	SMAD7	ENSG00000101665	-1.5938714008233614	[81,76]	[17,1]	-6	hSpCas9	positive selection	2956314
48950140	48950163	18	+	27013184	SW480	treatment with recombinant TRAIL	GAGCGCCTTCAGATCCGCCTCGG	SMAD7	ENSG00000101665	-1.280583782378602	[141,191]	[13,50]	-5	hSpCas9	positive selection	2956315
48950220	48950243	18	+	27013184	SW480	treatment with recombinant TRAIL	CACCTCGCACCGCCTTGCCCAGG	SMAD7	ENSG00000101665	2.14321681540569	[61,71]	[130,120]	8	hSpCas9	positive selection	2956316
48950392	48950415	18	+	27013184	SW480	treatment with recombinant TRAIL	CCGGACGAGCGCAGATCGTTTGG	SMAD7	ENSG00000101665	-1.7963105991834787	[237,186]	[36,11]	-7	hSpCas9	positive selection	2956317
48950406	48950429	18	+	27013184	SW480	treatment with recombinant TRAIL	ATCGTTTGGTCCTGAACATGCGG	SMAD7	ENSG00000101665	0.5703838689785685	[265,435]	[288,121]	3	hSpCas9	positive selection	2956318
48950407	48950430	18	+	27013184	SW480	treatment with recombinant TRAIL	TCGTTTGGTCCTGAACATGCGGG	SMAD7	ENSG00000101665	0.7882942449842575	[225,207]	[125,213]	4	hSpCas9	positive selection	2956319
48950408	48950431	18	+	27013184	SW480	treatment with recombinant TRAIL	CGTTTGGTCCTGAACATGCGGGG	SMAD7	ENSG00000101665	-0.16048132544709423	[212,199]	[48,123]	0	hSpCas9	positive selection	2956320
48950413	48950436	18	+	27013184	SW480	treatment with recombinant TRAIL	GGTCCTGAACATGCGGGGCGAGG	SMAD7	ENSG00000101665	1.6769429910834739	[96,172]	[167,200]	7	hSpCas9	positive selection	2956321
48948383	48948406	18	-	27013184	SW480	treatment with recombinant TRAIL	ATGGATTTTCTCAAACCAACTGG	SMAD7	ENSG00000101665	-0.3610202808827008	[62,72]	[25,17]	-2	hSpCas9	positive selection	2956322
48948402	48948425	18	-	27013184	SW480	treatment with recombinant TRAIL	TCCTTACTCCAGATACCCGATGG	SMAD7	ENSG00000101665	3.400515473045677	[333,188]	[1969,154]	9	hSpCas9	positive selection	2956323
48948394	48948417	18	+	27013184	SW480	treatment with recombinant TRAIL	GAGAAAATCCATCGGGTATCTGG	SMAD7	ENSG00000101665	0.20563928455528835	[377,533]	[194,263]	1	hSpCas9	positive selection	2956324
48942539	48942562	18	+	27013184	SW480	treatment with recombinant TRAIL	AGCATCTGGACAGTCTGCTGTGG	SMAD7	ENSG00000101665	-0.9144102113405779	[152,112]	[15,51]	-4	hSpCas9	positive selection	2956325
48948401	48948424	18	+	27013184	SW480	treatment with recombinant TRAIL	TCCATCGGGTATCTGGAGTAAGG	SMAD7	ENSG00000101665	-0.73217668190907	[72,77]	[7,35]	-3	hSpCas9	positive selection	2956326
48949806	48949829	18	+	27013184	SW480	treatment with recombinant TRAIL	TCTCACCTAGTTCGCAGAGTCGG	SMAD7	ENSG00000101665	-1.1976973615394275	[613,1017]	[242,17]	-5	hSpCas9	positive selection	2956327
48949812	48949835	18	+	27013184	SW480	treatment with recombinant TRAIL	CTAGTTCGCAGAGTCGGCTAAGG	SMAD7	ENSG00000101665	-0.45261237139608346	[219,34]	[29,60]	-2	hSpCas9	positive selection	2956328
48949818	48949841	18	+	27013184	SW480	treatment with recombinant TRAIL	CGCAGAGTCGGCTAAGGTGATGG	SMAD7	ENSG00000101665	0.9774723862717669	[116,242]	[141,156]	4	hSpCas9	positive selection	2956329
48949819	48949842	18	+	27013184	SW480	treatment with recombinant TRAIL	GCAGAGTCGGCTAAGGTGATGGG	SMAD7	ENSG00000101665	-0.07125355528942856	[302,385]	[94,203]	0	hSpCas9	positive selection	2956330
48949820	48949843	18	+	27013184	SW480	treatment with recombinant TRAIL	CAGAGTCGGCTAAGGTGATGGGG	SMAD7	ENSG00000101665	0.3014291021050557	[74,230]	[87,62]	1	hSpCas9	positive selection	2956331
48921863	48921886	18	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGATCGGTCACACTGGTGCGTGG	SMAD7	ENSG00000101665	0.6951372827200774	[3,3]	[3,6]	9	hSpCas9	positive selection	3022011
48921848	48921871	18	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	0.13697215183471867	[3,3]	[4,2]	3	hSpCas9	positive selection	3022012
48948387	48948410	18	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTTGGTTTGAGAAAATCCATCGG	SMAD7	ENSG00000101665	0.22298772669985398	[3,3]	[4,3]	5	hSpCas9	positive selection	3022013
48942476	48942499	18	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TCTTACCTGAAAGCCCCCCAGGG	SMAD7	ENSG00000101665	-0.0022449207505107482	[4,4]	[4,3]	0	hSpCas9	positive selection	3022014
48921863	48921886	18	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGATCGGTCACACTGGTGCGTGG	SMAD7	ENSG00000101665	0.45273940287037906	[3,3]	[3,3]	7	hSpCas9	positive selection	3089869
48921848	48921871	18	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	-0.14995659815138232	[3,3]	[3,1]	-2	hSpCas9	positive selection	3089870
48948387	48948410	18	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTTGGTTTGAGAAAATCCATCGG	SMAD7	ENSG00000101665	-0.17471115852817587	[3,3]	[2,1]	-3	hSpCas9	positive selection	3089871
48942476	48942499	18	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TCTTACCTGAAAGCCCCCCAGGG	SMAD7	ENSG00000101665	0.19962284148269732	[4,4]	[3,3]	3	hSpCas9	positive selection	3089872
48942474	48942497		+	24336571	A375	resistance to PLX after 7 days	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	-0.24563715422257743	[15,13]	[11,12]	-7	hSpCas9	positive selection	3146062
48921678	48921701		-	24336571	A375	resistance to PLX after 7 days	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	-0.16781241132297076	[12,11]	[10,10]	-5	hSpCas9	positive selection	3146063
48948402	48948425		-	24336571	A375	resistance to PLX after 7 days	TCCTTACTCCAGATACCCGATGG	SMAD7	ENSG00000101665	-0.23233698403001757	[5,5]	[3,4]	-7	hSpCas9	positive selection	3146064
48921740	48921763		+	24336571	A375	resistance to PLX after 7 days	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.05175918413402214	[53,51]	[54,53]	1	hSpCas9	positive selection	3146065
48942474	48942497		+	24336571	A375	resistance to PLX after 14 days	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	-0.7329949959996109	[20,15]	[3,4]	-8	hSpCas9	positive selection	3203855
48921678	48921701		-	24336571	A375	resistance to PLX after 14 days	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	0.9485417310696078	[13,8]	[9,10]	7	hSpCas9	positive selection	3203856
48948402	48948425		-	24336571	A375	resistance to PLX after 14 days	TCCTTACTCCAGATACCCGATGG	SMAD7	ENSG00000101665	-0.5617389948936495	[5,7]	[1,1]	-6	hSpCas9	positive selection	3203857
48921740	48921763		+	24336571	A375	resistance to PLX after 14 days	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.22825114009142755	[45,62]	[26,31]	2	hSpCas9	positive selection	3203858
48942474	48942497		+	24336571	A375	viability after 7 days	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.36293869468693746	[11]	[15,13]	5	hSpCas9	negative selection	3261648
48921678	48921701		-	24336571	A375	viability after 7 days	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	0.3712414392524235	[9]	[12,11]	5	hSpCas9	negative selection	3261649
48948402	48948425		-	24336571	A375	viability after 7 days	TCCTTACTCCAGATACCCGATGG	SMAD7	ENSG00000101665	-0.27427317119357586	[6]	[5,5]	-4	hSpCas9	negative selection	3261650
48921740	48921763		+	24336571	A375	viability after 7 days	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.3586451352852682	[42]	[53,51]	5	hSpCas9	negative selection	3261651
48942474	48942497		+	24336571	A375	viability after 14 days	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.6485535882316678	[11]	[20,15]	8	hSpCas9	negative selection	3319441
48921678	48921701		-	24336571	A375	viability after 14 days	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	0.26811871336125825	[9]	[13,8]	3	hSpCas9	negative selection	3319442
48948402	48948425		-	24336571	A375	viability after 14 days	TCCTTACTCCAGATACCCGATGG	SMAD7	ENSG00000101665	0.039672007990492975	[6]	[5,7]	0	hSpCas9	negative selection	3319443
48921740	48921763		+	24336571	A375	viability after 14 days	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.4270572405620041	[42]	[45,62]	5	hSpCas9	negative selection	3319444
48921868	48921891	18	+	27383988	293T	resistance to West Nile virus (flavivirus)	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-1.745488804161219	[512,512]	[0,0]	-9	hSpCas9	positive selection	3393753
48942474	48942497	18	+	27383988	293T	resistance to West Nile virus (flavivirus)	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	-0.42215388805961096	[204,204]	[0,0]	-3	hSpCas9	positive selection	3393754
48942516	48942539	18	-	27383988	293T	resistance to West Nile virus (flavivirus)	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	-0.748298337748043	[256,256]	[0,0]	-5	hSpCas9	positive selection	3393755
48921863	48921886	18	-	26780180	HT29	viability (Avana library 4 designs)	GGATCGGTCACACTGGTGCGTGG	SMAD7	ENSG00000101665	0.245294372816843	[]	[]	0	hSpCas9	negative selection	3460585
48921848	48921871	18	-	26780180	HT29	viability (Avana library 4 designs)	GTGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	0.310277198437849	[]	[]	1	hSpCas9	negative selection	3460586
48948386	48948409	18	+	26780180	HT29	viability (Avana library 4 designs)	GTTGGTTTGAGAAAATCCATCGG	SMAD7	ENSG00000101665	0.679297270668403	[]	[]	2	hSpCas9	negative selection	3460587
48942475	48942498	18	+	26780180	HT29	viability (Avana library 4 designs)	TCTTACCTGAAAGCCCCCCAGGG	SMAD7	ENSG00000101665	-0.129978955287497	[]	[]	-2	hSpCas9	negative selection	3460588
48921863	48921886	18	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGATCGGTCACACTGGTGCGTGG	SMAD7	ENSG00000101665	4.63980528898316	[]	[]	7	hSpCas9	negative selection	3561033
48948386	48948409	18	+	26780180	A375	viability (Avana lentiCRISPRv2)	GTTGGTTTGAGAAAATCCATCGG	SMAD7	ENSG00000101665	-4.23589422830296	[]	[]	-5	hSpCas9	negative selection	3561034
48942475	48942498	18	+	26780180	A375	viability (Avana lentiCRISPRv2)	TCTTACCTGAAAGCCCCCCAGGG	SMAD7	ENSG00000101665	3.25478898962369	[]	[]	5	hSpCas9	negative selection	3561035
48921848	48921871	18	-	26780180	A375	viability (Avana lentiCRISPRv2)	GTGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	4.58100777048358	[]	[]	7	hSpCas9	negative selection	3561036
48942509	48942532	18	+	26780180	A375	viability (Avana lentiCRISPRv2)	CGTTCCCCCTGTTTCAGCGGAGG	SMAD7	ENSG00000101665	3.24273106952569	[]	[]	5	hSpCas9	negative selection	3561037
48921740	48921763	18	+	26780180	A375	viability (Avana lentiCRISPRv2)	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	5.24247830429229	[]	[]	8	hSpCas9	negative selection	3561038
48921863	48921886	18	-	26780180	A375	viability (Avana lentiGuide)	GGATCGGTCACACTGGTGCGTGG	SMAD7	ENSG00000101665	-2.61306855855356	[]	[]	-4	hSpCas9	negative selection	3669692
48948386	48948409	18	+	26780180	A375	viability (Avana lentiGuide)	GTTGGTTTGAGAAAATCCATCGG	SMAD7	ENSG00000101665	1.83196708789979	[]	[]	2	hSpCas9	negative selection	3669693
48942475	48942498	18	+	26780180	A375	viability (Avana lentiGuide)	TCTTACCTGAAAGCCCCCCAGGG	SMAD7	ENSG00000101665	-2.3773768012475	[]	[]	-4	hSpCas9	negative selection	3669694
48921848	48921871	18	-	26780180	A375	viability (Avana lentiGuide)	GTGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	1.80286299192505	[]	[]	2	hSpCas9	negative selection	3669695
48942509	48942532	18	+	26780180	A375	viability (Avana lentiGuide)	CGTTCCCCCTGTTTCAGCGGAGG	SMAD7	ENSG00000101665	14.4077809863297	[]	[]	8	hSpCas9	negative selection	3669696
48921740	48921763	18	+	26780180	A375	viability (Avana lentiGuide)	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.575263458628793	[]	[]	0	hSpCas9	negative selection	3669697
48921863	48921886	18	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGATCGGTCACACTGGTGCGTGG	SMAD7	ENSG00000101665	0.32011650574705863	[5]	[6,6]	8	hSpCas9	positive selection	3778299
48948386	48948409	18	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTTGGTTTGAGAAAATCCATCGG	SMAD7	ENSG00000101665	-0.7328382101762957	[5]	[4,0]	-8	hSpCas9	positive selection	3778300
48942475	48942498	18	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TCTTACCTGAAAGCCCCCCAGGG	SMAD7	ENSG00000101665	0.10794230319282559	[5]	[6,5]	3	hSpCas9	positive selection	3778301
48921848	48921871	18	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	0.26049073949011714	[4]	[5,5]	7	hSpCas9	positive selection	3778302
48942509	48942532	18	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CGTTCCCCCTGTTTCAGCGGAGG	SMAD7	ENSG00000101665	0.35848598381348784	[4]	[5,5]	9	hSpCas9	positive selection	3778303
48921740	48921763	18	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.2526042452641807	[5]	[6,6]	7	hSpCas9	positive selection	3778304
48921863	48921886	18	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGATCGGTCACACTGGTGCGTGG	SMAD7	ENSG00000101665	-0.24671133282909827	[5]	[3,3]	-3	hSpCas9	positive selection	3886906
48948386	48948409	18	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTTGGTTTGAGAAAATCCATCGG	SMAD7	ENSG00000101665	-0.0840035940979103	[5]	[4,3]	-1	hSpCas9	positive selection	3886907
48942475	48942498	18	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TCTTACCTGAAAGCCCCCCAGGG	SMAD7	ENSG00000101665	0.10663301885682752	[6]	[5,5]	2	hSpCas9	positive selection	3886908
48921848	48921871	18	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	0.2382984440987032	[5]	[5,5]	6	hSpCas9	positive selection	3886909
48942509	48942532	18	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CGTTCCCCCTGTTTCAGCGGAGG	SMAD7	ENSG00000101665	0.16791865530410452	[5]	[4,5]	4	hSpCas9	positive selection	3886910
48921740	48921763	18	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.07414533341715485	[6]	[6,4]	1	hSpCas9	positive selection	3886911
48942474	48942497	18	+	26780180	A375	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	1.99502478891613	[]	[]	9	hSpCas9	negative selection	3997024
48921868	48921891	18	+	26780180	A375	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	0.362190265750354	[]	[]	0	hSpCas9	negative selection	3997025
48950392	48950415	18	-	26780180	A375	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	1.26797135775795	[]	[]	7	hSpCas9	negative selection	3997026
48949811	48949834	18	-	26780180	A375	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	0.795979604471295	[]	[]	3	hSpCas9	negative selection	3997027
48942516	48942539	18	-	26780180	A375	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	1.02391459747221	[]	[]	5	hSpCas9	negative selection	3997028
48921740	48921763	18	+	26780180	A375	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.657426181892295	[]	[]	2	hSpCas9	negative selection	3997029
48942474	48942497	18	+	26780180	HT29	viability (GeCKOv2 library)	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	1.54026814749545	[]	[]	7	hSpCas9	negative selection	4104990
48921868	48921891	18	+	26780180	HT29	viability (GeCKOv2 library)	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	0.887599721038268	[]	[]	4	hSpCas9	negative selection	4104991
48950392	48950415	18	-	26780180	HT29	viability (GeCKOv2 library)	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	2.08880231190715	[]	[]	9	hSpCas9	negative selection	4104992
48949811	48949834	18	-	26780180	HT29	viability (GeCKOv2 library)	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	0.327594993679172	[]	[]	0	hSpCas9	negative selection	4104993
48942516	48942539	18	-	26780180	HT29	viability (GeCKOv2 library)	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	1.31632791179226	[]	[]	6	hSpCas9	negative selection	4104994
48921740	48921763	18	+	26780180	HT29	viability (GeCKOv2 library)	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.0630534979160741	[]	[]	0	hSpCas9	negative selection	4104995
48942474	48942497	18	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.12147029212632246	[3]	[3,2]	3	hSpCas9	positive selection	4172138
48921678	48921701	18	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	0.3607934444114763	[3]	[2,3]	8	hSpCas9	positive selection	4172139
48948402	48948425	18	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TCCTTACTCCAGATACCCGATGG	SMAD7	ENSG00000101665	-0.19591900488676184	[2]	[1,0]	-4	hSpCas9	positive selection	4172140
48921740	48921763	18	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.28029498572191636	[5]	[4,4]	7	hSpCas9	positive selection	4172141
48942474	48942497	18	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.0780819341163464	[3]	[1,0,2,0]	0	hSpCas9	positive selection	4236160
48921678	48921701	18	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	-0.32985911200418616	[4]	[3,0,1,0]	-5	hSpCas9	positive selection	4236161
48948402	48948425	18	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TCCTTACTCCAGATACCCGATGG	SMAD7	ENSG00000101665	1.1234112824786058	[2]	[2,0,1,2]	8	hSpCas9	positive selection	4236162
48921740	48921763	18	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.4600479417663256	[5]	[1,2,2,3]	3	hSpCas9	positive selection	4236163
48921740	48921763	18	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.3496350656408709	[3]	[3,3]	7	hSpCas9	positive selection	4299216
48950392	48950415	18	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.23245124635037306	[3]	[3,2]	5	hSpCas9	positive selection	4299217
48949811	48949834	18	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	0.06933305459627603	[3]	[3,2]	1	hSpCas9	positive selection	4299218
48921868	48921891	18	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.1029183258191857	[4]	[3,2]	-2	hSpCas9	positive selection	4363469
48942474	48942497	18	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	-0.2369493267713422	[3]	[3,0]	-5	hSpCas9	positive selection	4363470
48942516	48942539	18	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.1454963395087852	[3]	[2,2]	3	hSpCas9	positive selection	4363471
48921769	48921791	18	-	27760321	OCIAML3	viability	ATGATCTACCTCAGGGGAATGG	SMAD7	ENSG00000101665	0.41349284256663305	[340,256]	[238,399]	5	hSpCas9	negative selection	4441223
48921788	48921810	18	+	27760321	OCIAML3	viability	CATAGAAGATATCCAGAGAGGG	SMAD7	ENSG00000101665	0.5389478965930934	[69,57]	[51,98]	6	hSpCas9	negative selection	4441224
48921848	48921870	18	-	27760321	OCIAML3	viability	TGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	0.2949949448763085	[729,548]	[624,586]	3	hSpCas9	negative selection	4441225
48921863	48921885	18	-	27760321	OCIAML3	viability	GATCGGTCACACTGGTGCGTGG	SMAD7	ENSG00000101665	-0.14600776139664662	[930,808]	[648,566]	-1	hSpCas9	negative selection	4441226
48942489	48942511	18	-	27760321	OCIAML3	viability	CGAATTATCTGGCCCCTGGGGG	SMAD7	ENSG00000101665	0.24178382015243494	[959,779]	[703,925]	3	hSpCas9	negative selection	4441227
48921769	48921791	18	-	27760321	OCIAML2	viability	ATGATCTACCTCAGGGGAATGG	SMAD7	ENSG00000101665	0.04487870437510488	[340,256]	[262,226]	0	hSpCas9	negative selection	4524686
48921788	48921810	18	+	27760321	OCIAML2	viability	CATAGAAGATATCCAGAGAGGG	SMAD7	ENSG00000101665	0.7705761452117206	[69,57]	[55,129]	9	hSpCas9	negative selection	4524687
48921848	48921870	18	-	27760321	OCIAML2	viability	TGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	0.3369389868277365	[729,548]	[587,726]	4	hSpCas9	negative selection	4524688
48921863	48921885	18	-	27760321	OCIAML2	viability	GATCGGTCACACTGGTGCGTGG	SMAD7	ENSG00000101665	0.6699343967770317	[930,808]	[1078,1166]	8	hSpCas9	negative selection	4524689
48942489	48942511	18	-	27760321	OCIAML2	viability	CGAATTATCTGGCCCCTGGGGG	SMAD7	ENSG00000101665	0.15545469394618006	[959,779]	[664,930]	2	hSpCas9	negative selection	4524690
48921769	48921791	18	-	27760321	MV411	viability	ATGATCTACCTCAGGGGAATGG	SMAD7	ENSG00000101665	1.5038467798919997	[340,256]	[739,276]	9	hSpCas9	negative selection	4608149
48921788	48921810	18	+	27760321	MV411	viability	CATAGAAGATATCCAGAGAGGG	SMAD7	ENSG00000101665	-1.0305089231195743	[69,57]	[0,49]	-6	hSpCas9	negative selection	4608150
48921848	48921870	18	-	27760321	MV411	viability	TGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	0.10503408405804526	[729,548]	[563,278]	0	hSpCas9	negative selection	4608151
48921863	48921885	18	-	27760321	MV411	viability	GATCGGTCACACTGGTGCGTGG	SMAD7	ENSG00000101665	-0.07553738339697158	[930,808]	[640,396]	0	hSpCas9	negative selection	4608152
48942489	48942511	18	-	27760321	MV411	viability	CGAATTATCTGGCCCCTGGGGG	SMAD7	ENSG00000101665	0.24098422139402031	[959,779]	[377,1120]	1	hSpCas9	negative selection	4608153
48921769	48921791	18	-	27760321	HL60	viability	ATGATCTACCTCAGGGGAATGG	SMAD7	ENSG00000101665	-0.37564588437136126	[340,256]	[209,161]	-4	hSpCas9	negative selection	4691612
48921788	48921810	18	+	27760321	HL60	viability	CATAGAAGATATCCAGAGAGGG	SMAD7	ENSG00000101665	0.37415290754454134	[69,57]	[32,103]	4	hSpCas9	negative selection	4691613
48921848	48921870	18	-	27760321	HL60	viability	TGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	-0.46474158187453735	[729,548]	[337,414]	-5	hSpCas9	negative selection	4691614
48921863	48921885	18	-	27760321	HL60	viability	GATCGGTCACACTGGTGCGTGG	SMAD7	ENSG00000101665	-0.18243767366818897	[930,808]	[664,581]	-2	hSpCas9	negative selection	4691615
48942489	48942511	18	-	27760321	HL60	viability	CGAATTATCTGGCCCCTGGGGG	SMAD7	ENSG00000101665	-0.30383451206314227	[959,779]	[546,599]	-3	hSpCas9	negative selection	4691616
48921769	48921791	18	-	27760321	HT1080	viability	ATGATCTACCTCAGGGGAATGG	SMAD7	ENSG00000101665	-0.872450685801174	[256,200]	[77,18]	-4	hSpCas9	negative selection	4775075
48921788	48921810	18	+	27760321	HT1080	viability	CATAGAAGATATCCAGAGAGGG	SMAD7	ENSG00000101665	-4.358155539743308	[57,44]	[0,0]	-8	hSpCas9	negative selection	4775076
48921848	48921870	18	-	27760321	HT1080	viability	TGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	0.533158248057658	[548,428]	[79,502]	3	hSpCas9	negative selection	4775077
48921863	48921885	18	-	27760321	HT1080	viability	GATCGGTCACACTGGTGCGTGG	SMAD7	ENSG00000101665	0.15347972517838815	[808,630]	[255,387]	0	hSpCas9	negative selection	4775078
48942489	48942511	18	-	27760321	HT1080	viability	CGAATTATCTGGCCCCTGGGGG	SMAD7	ENSG00000101665	0.7455638052862802	[779,608]	[355,581]	4	hSpCas9	negative selection	4775079
48921769	48921791	18	-	27760321	HT29	viability after 7 days	ATGATCTACCTCAGGGGAATGG	SMAD7	ENSG00000101665	-0.03692498123101773	[256,200]	[242,343,267]	0	hSpCas9	negative selection	4858538
48921788	48921810	18	+	27760321	HT29	viability after 7 days	CATAGAAGATATCCAGAGAGGG	SMAD7	ENSG00000101665	-0.3634237367896054	[57,44]	[52,65,35]	-5	hSpCas9	negative selection	4858539
48921848	48921870	18	-	27760321	HT29	viability after 7 days	TGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	0.27769378956175544	[548,428]	[931,654,723]	4	hSpCas9	negative selection	4858540
48921863	48921885	18	-	27760321	HT29	viability after 7 days	GATCGGTCACACTGGTGCGTGG	SMAD7	ENSG00000101665	0.33267690738088995	[808,630]	[1477,1020,1044]	5	hSpCas9	negative selection	4858541
48942489	48942511	18	-	27760321	HT29	viability after 7 days	CGAATTATCTGGCCCCTGGGGG	SMAD7	ENSG00000101665	0.24712233094832003	[779,608]	[1016,944,1204]	4	hSpCas9	negative selection	4858542
48921769	48921791	18	-	27760321	HT29	viability after 25 days	ATGATCTACCTCAGGGGAATGG	SMAD7	ENSG00000101665	0.13039145631431137	[256,200]	[330,240,283]	1	hSpCas9	negative selection	4942001
48921788	48921810	18	+	27760321	HT29	viability after 25 days	CATAGAAGATATCCAGAGAGGG	SMAD7	ENSG00000101665	1.6396900378124564	[57,44]	[134,326,79]	9	hSpCas9	negative selection	4942002
48921848	48921870	18	-	27760321	HT29	viability after 25 days	TGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	0.25687467634786604	[548,428]	[875,490,616]	2	hSpCas9	negative selection	4942003
48921863	48921885	18	-	27760321	HT29	viability after 25 days	GATCGGTCACACTGGTGCGTGG	SMAD7	ENSG00000101665	0.5730772465197136	[808,630]	[1108,1280,1294]	6	hSpCas9	negative selection	4942004
48942489	48942511	18	-	27760321	HT29	viability after 25 days	CGAATTATCTGGCCCCTGGGGG	SMAD7	ENSG00000101665	0.17362887080471656	[779,608]	[677,891,1154]	1	hSpCas9	negative selection	4942005
48921769	48921791	18	-	27760321	HT29	viability after 22 days	ATGATCTACCTCAGGGGAATGG	SMAD7	ENSG00000101665	0.38030078594199995	[256,200]	[317,328,387]	4	hSpCas9	negative selection	5025464
48921788	48921810	18	+	27760321	HT29	viability after 22 days	CATAGAAGATATCCAGAGAGGG	SMAD7	ENSG00000101665	0.7799010294566169	[57,44]	[62,206,36]	8	hSpCas9	negative selection	5025465
48921848	48921870	18	-	27760321	HT29	viability after 22 days	TGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	0.00526977185463956	[548,428]	[729,383,583]	0	hSpCas9	negative selection	5025466
48921863	48921885	18	-	27760321	HT29	viability after 22 days	GATCGGTCACACTGGTGCGTGG	SMAD7	ENSG00000101665	0.5387412625832853	[808,630]	[1080,1525,1021]	6	hSpCas9	negative selection	5025467
48942489	48942511	18	-	27760321	HT29	viability after 22 days	CGAATTATCTGGCCCCTGGGGG	SMAD7	ENSG00000101665	0.11880402106151411	[779,608]	[939,650,1023]	1	hSpCas9	negative selection	5025468
48921769	48921791	18	-	27760321	HT29	viability after 19 days	ATGATCTACCTCAGGGGAATGG	SMAD7	ENSG00000101665	0.4441516889085314	[256,200]	[435,91,541]	4	hSpCas9	negative selection	5108927
48921788	48921810	18	+	27760321	HT29	viability after 19 days	CATAGAAGATATCCAGAGAGGG	SMAD7	ENSG00000101665	1.2122350061605494	[57,44]	[109,202,94]	9	hSpCas9	negative selection	5108928
48921848	48921870	18	-	27760321	HT29	viability after 19 days	TGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	0.5838686784761156	[548,428]	[1039,536,953]	6	hSpCas9	negative selection	5108929
48921863	48921885	18	-	27760321	HT29	viability after 19 days	GATCGGTCACACTGGTGCGTGG	SMAD7	ENSG00000101665	0.7611770172404482	[808,630]	[1149,1477,1526]	7	hSpCas9	negative selection	5108930
48942489	48942511	18	-	27760321	HT29	viability after 19 days	CGAATTATCTGGCCCCTGGGGG	SMAD7	ENSG00000101665	0.11990353032195322	[779,608]	[847,949,791]	1	hSpCas9	negative selection	5108931
48921769	48921791	18	-	27760321	HT29	viability after 16 days	ATGATCTACCTCAGGGGAATGG	SMAD7	ENSG00000101665	-0.3129904842669282	[256,200]	[263,137,223]	-3	hSpCas9	negative selection	5192390
48921788	48921810	18	+	27760321	HT29	viability after 16 days	CATAGAAGATATCCAGAGAGGG	SMAD7	ENSG00000101665	-0.3709260166283648	[57,44]	[50,52,29]	-4	hSpCas9	negative selection	5192391
48921848	48921870	18	-	27760321	HT29	viability after 16 days	TGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	0.39532116158447655	[548,428]	[777,613,774]	4	hSpCas9	negative selection	5192392
48921863	48921885	18	-	27760321	HT29	viability after 16 days	GATCGGTCACACTGGTGCGTGG	SMAD7	ENSG00000101665	0.6104085385134692	[808,630]	[1285,1474,926]	7	hSpCas9	negative selection	5192393
48942489	48942511	18	-	27760321	HT29	viability after 16 days	CGAATTATCTGGCCCCTGGGGG	SMAD7	ENSG00000101665	0.3303862234990208	[779,608]	[989,1055,883]	3	hSpCas9	negative selection	5192394
48921769	48921791	18	-	27760321	HT29	viability after 13 days	ATGATCTACCTCAGGGGAATGG	SMAD7	ENSG00000101665	0.1567132111941238	[256,200]	[380,222,284]	2	hSpCas9	negative selection	5275853
48921788	48921810	18	+	27760321	HT29	viability after 13 days	CATAGAAGATATCCAGAGAGGG	SMAD7	ENSG00000101665	0.7932730186804569	[57,44]	[157,127,28]	9	hSpCas9	negative selection	5275854
48921848	48921870	18	-	27760321	HT29	viability after 13 days	TGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	0.3243721109197795	[548,428]	[859,719,559]	4	hSpCas9	negative selection	5275855
48921863	48921885	18	-	27760321	HT29	viability after 13 days	GATCGGTCACACTGGTGCGTGG	SMAD7	ENSG00000101665	0.6470870033399696	[808,630]	[1286,1553,1095]	8	hSpCas9	negative selection	5275856
48942489	48942511	18	-	27760321	HT29	viability after 13 days	CGAATTATCTGGCCCCTGGGGG	SMAD7	ENSG00000101665	0.33694656789070987	[779,608]	[973,1010,1064]	4	hSpCas9	negative selection	5275857
48921769	48921791	18	-	27760321	HT29	viability after 10 days	ATGATCTACCTCAGGGGAATGG	SMAD7	ENSG00000101665	-0.12139782094786977	[256,200]	[186,304,296]	-2	hSpCas9	negative selection	5359316
48921788	48921810	18	+	27760321	HT29	viability after 10 days	CATAGAAGATATCCAGAGAGGG	SMAD7	ENSG00000101665	1.1278929498477448	[57,44]	[175,216,32]	9	hSpCas9	negative selection	5359317
48921848	48921870	18	-	27760321	HT29	viability after 10 days	TGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	0.5681232634313913	[548,428]	[941,695,1067]	7	hSpCas9	negative selection	5359318
48921863	48921885	18	-	27760321	HT29	viability after 10 days	GATCGGTCACACTGGTGCGTGG	SMAD7	ENSG00000101665	0.32238210422594826	[808,630]	[949,1204,1216]	4	hSpCas9	negative selection	5359319
48942489	48942511	18	-	27760321	HT29	viability after 10 days	CGAATTATCTGGCCCCTGGGGG	SMAD7	ENSG00000101665	0.23887511312619447	[779,608]	[748,1171,1149]	3	hSpCas9	negative selection	5359320
48921769	48921791	18	-	27760321	MOLM13	viability	ATGATCTACCTCAGGGGAATGG	SMAD7	ENSG00000101665	-0.1343192602983292	[340,256]	[186,122]	-1	hSpCas9	negative selection	5442779
48921788	48921810	18	+	27760321	MOLM13	viability	CATAGAAGATATCCAGAGAGGG	SMAD7	ENSG00000101665	1.4129667001249415	[69,57]	[206,0]	8	hSpCas9	negative selection	5442780
48921848	48921870	18	-	27760321	MOLM13	viability	TGCGTGGTGGCATACTGGGAGG	SMAD7	ENSG00000101665	0.3955070045224014	[729,548]	[313,603]	2	hSpCas9	negative selection	5442781
48921863	48921885	18	-	27760321	MOLM13	viability	GATCGGTCACACTGGTGCGTGG	SMAD7	ENSG00000101665	0.4882374230572497	[930,808]	[594,764]	3	hSpCas9	negative selection	5442782
48942489	48942511	18	-	27760321	MOLM13	viability	CGAATTATCTGGCCCCTGGGGG	SMAD7	ENSG00000101665	-0.3604980670541037	[959,779]	[348,406]	-2	hSpCas9	negative selection	5442783
48948856	48948879	18	+	27661255	K562	viability	GCACTCGCGCGGGGGACACGGGG	SMAD7	ENSG00000101665	0.23363484100699428	[352,469]	[478,303]	7	dCas9-KRAB	negative selection	5512788
48949277	48949300	18	+	27661255	K562	viability	GCGCGGCCACGACAGTATCTGGG	SMAD7	ENSG00000101665	0.3072532264471639	[270,322]	[344,247]	8	dCas9-KRAB	negative selection	5512789
48950636	48950659	18	+	27661255	K562	viability	GGGCGCCCGCCGGGGATCGGGGG	SMAD7	ENSG00000101665	0.11279122057202097	[624,813]	[678,566]	4	dCas9-KRAB	negative selection	5512790
48948948	48948971	18	-	27661255	K562	viability	GTGATGTGAGGGTTCACCCCGGG	SMAD7	ENSG00000101665	-0.00025979348070387376	[624,699]	[574,487]	0	dCas9-KRAB	negative selection	5512791
48921740	48921763	18	+	27260156	BXPC3	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.20418789216247835	[688]	[737,757,768,1094]	4	hSpCas9	negative selection	5571676
48950392	48950415	18	-	27260156	BXPC3	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.1793698954714088	[597]	[583,756,692,816]	4	hSpCas9	negative selection	5571677
48949811	48949834	18	-	27260156	BXPC3	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.13587102783921456	[958]	[836,844,922,1070]	-3	hSpCas9	negative selection	5571678
48921868	48921891	18	+	27260156	BXPC3	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	0.0014376125242672178	[1739]	[1857,1696,1719,2022]	0	hSpCas9	negative selection	5635929
48942474	48942497	18	+	27260156	BXPC3	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.12296038756633604	[560]	[566,592,626,792]	2	hSpCas9	negative selection	5635930
48942516	48942539	18	-	27260156	BXPC3	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.11695879457191978	[511]	[518,463,665,698]	2	hSpCas9	negative selection	5635931
48921740	48921763	18	+	27260156	A673	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.33701214796874435	[688]	[1176,1023,1087,895]	7	hSpCas9	negative selection	5692927
48950392	48950415	18	-	27260156	A673	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.25101765381285024	[597]	[911,872,696,946]	6	hSpCas9	negative selection	5692928
48949811	48949834	18	-	27260156	A673	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.15218806265025764	[958]	[1200,954,1008,996]	-4	hSpCas9	negative selection	5692929
48921868	48921891	18	+	27260156	A673	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.09917117051511415	[1739]	[2248,1855,1743,1989]	-2	hSpCas9	negative selection	5757180
48942474	48942497	18	+	27260156	A673	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	-0.11841830644695522	[560]	[638,591,655,594]	-3	hSpCas9	negative selection	5757181
48942516	48942539	18	-	27260156	A673	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.1886381710773376	[511]	[846,755,533,679]	4	hSpCas9	negative selection	5757182
48921740	48921763	18	+	27260156	A375	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.4053017196155284	[688]	[1126,1297,960,922]	6	hSpCas9	negative selection	5814178
48950392	48950415	18	-	27260156	A375	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.2878943573519348	[597]	[805,868,895,839]	4	hSpCas9	negative selection	5814179
48949811	48949834	18	-	27260156	A375	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.15568568746978928	[958]	[966,1020,859,1153]	-2	hSpCas9	negative selection	5814180
48921868	48921891	18	+	27260156	A375	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.02566879887330109	[1739]	[1882,2774,2054,1439]	0	hSpCas9	negative selection	5878431
48942474	48942497	18	+	27260156	A375	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.2820198640381212	[560]	[760,1233,671,600]	4	hSpCas9	negative selection	5878432
48942516	48942539	18	-	27260156	A375	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.4914516231198074	[511]	[847,986,879,683]	7	hSpCas9	negative selection	5878433
48921740	48921763	18	+	27260156	COLO741	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.4665507013095125	[688]	[1229,953,1445]	8	hSpCas9	negative selection	5935429
48950392	48950415	18	-	27260156	COLO741	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.12135113839040246	[597]	[976,840,695]	2	hSpCas9	negative selection	5935430
48949811	48949834	18	-	27260156	COLO741	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	0.01760555945800002	[958]	[1261,1090,1357]	0	hSpCas9	negative selection	5935431
48921868	48921891	18	+	27260156	COLO741	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.08492091790670209	[1739]	[2251,1898,2141]	-2	hSpCas9	negative selection	5999682
48942474	48942497	18	+	27260156	COLO741	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.16481906946508207	[560]	[822,944,653]	3	hSpCas9	negative selection	5999683
48942516	48942539	18	-	27260156	COLO741	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.3826177240420984	[511]	[737,911,893]	7	hSpCas9	negative selection	5999684
48921740	48921763	18	+	27260156	CAL120	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.385462359372997	[688]	[1411,1071,922]	6	hSpCas9	negative selection	6056680
48950392	48950415	18	-	27260156	CAL120	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.28936057758212597	[597]	[749,938,1012]	4	hSpCas9	negative selection	6056681
48949811	48949834	18	-	27260156	CAL120	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	0.20845443707683597	[958]	[2023,1214,1000]	3	hSpCas9	negative selection	6056682
48921868	48921891	18	+	27260156	CAL120	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.18342695670833176	[1739]	[2273,1725,1776]	-3	hSpCas9	negative selection	6120933
48942474	48942497	18	+	27260156	CAL120	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.1169174572190898	[560]	[591,731,918]	1	hSpCas9	negative selection	6120934
48942516	48942539	18	-	27260156	CAL120	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.5676534710180533	[511]	[1543,729,653]	8	hSpCas9	negative selection	6120935
48921740	48921763	18	+	27260156	CADOES1	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.4208809253432665	[688]	[866,819,998,740]	7	hSpCas9	negative selection	6177931
48950392	48950415	18	-	27260156	CADOES1	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.09311728434802591	[597]	[620,573,607,568]	1	hSpCas9	negative selection	6177932
48949811	48949834	18	-	27260156	CADOES1	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.1784180154992575	[958]	[824,837,744,742]	-3	hSpCas9	negative selection	6177933
48921868	48921891	18	+	27260156	CADOES1	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.10864969397322377	[1739]	[1724,1318,1372,1588]	-2	hSpCas9	negative selection	6242184
48942474	48942497	18	+	27260156	CADOES1	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	-0.13394970908132092	[560]	[481,441,499,477]	-2	hSpCas9	negative selection	6242185
48942516	48942539	18	-	27260156	CADOES1	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.39545970993398993	[511]	[585,607,544,771]	6	hSpCas9	negative selection	6242186
48921740	48921763	18	+	27260156	EWS502	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.4008237616389235	[688]	[909,867,1085,1000]	7	hSpCas9	negative selection	6299182
48950392	48950415	18	-	27260156	EWS502	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.020538785666089132	[597]	[755,480,708,612]	0	hSpCas9	negative selection	6299183
48949811	48949834	18	-	27260156	EWS502	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.13847761466691777	[958]	[690,956,1104,966]	-2	hSpCas9	negative selection	6299184
48921868	48921891	18	+	27260156	EWS502	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.18450878458096143	[1739]	[1361,1779,1507,1871]	-3	hSpCas9	negative selection	6363435
48942474	48942497	18	+	27260156	EWS502	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	-0.18232151487868936	[560]	[415,534,546,613]	-3	hSpCas9	negative selection	6363436
48942516	48942539	18	-	27260156	EWS502	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.21616773110303605	[511]	[582,711,549,676]	4	hSpCas9	negative selection	6363437
48921740	48921763	18	+	27260156	EW8	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.4719102409084095	[688]	[580,724,895,850]	8	hSpCas9	negative selection	6420433
48950392	48950415	18	-	27260156	EW8	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.24593080204412365	[597]	[677,716,351,599]	4	hSpCas9	negative selection	6420434
48949811	48949834	18	-	27260156	EW8	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.23166163503463122	[958]	[755,693,568,652]	-4	hSpCas9	negative selection	6420435
48921868	48921891	18	+	27260156	EW8	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.11916735692485636	[1739]	[1621,1305,914,1446]	-2	hSpCas9	negative selection	6484686
48942474	48942497	18	+	27260156	EW8	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.05633690161018995	[560]	[631,401,304,595]	1	hSpCas9	negative selection	6484687
48942516	48942539	18	-	27260156	EW8	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.4397415418238807	[511]	[711,429,486,648]	7	hSpCas9	negative selection	6484688
48921740	48921763	18	+	27260156	CORL105	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	-0.06683878466063925	[688]	[603,664,1111,748]	-1	hSpCas9	negative selection	6541684
48950392	48950415	18	-	27260156	CORL105	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	-0.015323645233451755	[597]	[575,609,909,705]	0	hSpCas9	negative selection	6541685
48949811	48949834	18	-	27260156	CORL105	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.43886484441318585	[958]	[792,589,884,1055]	-7	hSpCas9	negative selection	6541686
48921868	48921891	18	+	27260156	CORL105	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.28570946294858235	[1739]	[1812,1430,1866,1612]	-5	hSpCas9	negative selection	6605937
48942474	48942497	18	+	27260156	CORL105	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	-0.2006441329471806	[560]	[494,564,665,571]	-4	hSpCas9	negative selection	6605938
48942516	48942539	18	-	27260156	CORL105	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	-0.03539259653343607	[511]	[495,543,731,587]	0	hSpCas9	negative selection	6605939
48921740	48921763	18	+	27260156	HS294T	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.12875361684509856	[688]	[281,323,235,327]	1	hSpCas9	negative selection	6662935
48950392	48950415	18	-	27260156	HS294T	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.18751655213526552	[597]	[219,210,275,368]	2	hSpCas9	negative selection	6662936
48949811	48949834	18	-	27260156	HS294T	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.515484424919592	[958]	[238,267,258,274]	-6	hSpCas9	negative selection	6662937
48921868	48921891	18	+	27260156	HS294T	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.12240071547331	[1739]	[582,666,447,804]	-2	hSpCas9	negative selection	6727188
48942474	48942497	18	+	27260156	HS294T	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	-0.20938883011755002	[560]	[142,159,159,312]	-3	hSpCas9	negative selection	6727189
48942516	48942539	18	-	27260156	HS294T	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	-0.2150632260059418	[511]	[140,167,167,214]	-3	hSpCas9	negative selection	6727190
48921740	48921763	18	+	27260156	HCC44	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.05396759722465805	[688]	[828,742,1040,671]	0	hSpCas9	negative selection	6784186
48950392	48950415	18	-	27260156	HCC44	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.20825428115049038	[597]	[727,876,707,774]	3	hSpCas9	negative selection	6784187
48949811	48949834	18	-	27260156	HCC44	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.1640049232729367	[958]	[1142,918,1043,799]	-3	hSpCas9	negative selection	6784188
48921868	48921891	18	+	27260156	HCC44	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.025493129628068045	[1739]	[1550,2043,1855,2193]	0	hSpCas9	negative selection	6848439
48942474	48942497	18	+	27260156	HCC44	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	-0.24489715955709712	[560]	[335,474,892,486]	-4	hSpCas9	negative selection	6848440
48942516	48942539	18	-	27260156	HCC44	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.13732032980813696	[511]	[769,509,631,658]	2	hSpCas9	negative selection	6848441
48921740	48921763	18	+	27260156	G402	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.283671078751352	[688]	[1358,1105,1080,616]	3	hSpCas9	negative selection	6905437
48950392	48950415	18	-	27260156	G402	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.3924183370354851	[597]	[1026,674,1416,713]	5	hSpCas9	negative selection	6905438
48949811	48949834	18	-	27260156	G402	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.5545706155170871	[958]	[926,833,672,771]	-6	hSpCas9	negative selection	6905439
48921868	48921891	18	+	27260156	G402	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	0.019524105946691517	[1739]	[3232,2367,1659,1537]	0	hSpCas9	negative selection	6969690
48942474	48942497	18	+	27260156	G402	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.5600806431458979	[560]	[1035,771,1054,1152]	7	hSpCas9	negative selection	6969691
48942516	48942539	18	-	27260156	G402	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.780321689245305	[511]	[958,805,1229,1251]	8	hSpCas9	negative selection	6969692
48921740	48921763	18	+	27260156	L33	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.33677958807056574	[688]	[811,296,720,799]	7	hSpCas9	negative selection	7026688
48950392	48950415	18	-	27260156	L33	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.4127110797271437	[597]	[814,354,500,705]	8	hSpCas9	negative selection	7026689
48949811	48949834	18	-	27260156	L33	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.17765846749972436	[958]	[832,326,534,908]	-4	hSpCas9	negative selection	7026690
48921868	48921891	18	+	27260156	L33	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.18429248838306078	[1739]	[1468,593,875,1810]	-4	hSpCas9	negative selection	7090941
48942474	48942497	18	+	27260156	L33	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.14338018550008108	[560]	[624,256,348,669]	3	hSpCas9	negative selection	7090942
48942516	48942539	18	-	27260156	L33	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	-0.11202597966608852	[511]	[445,207,274,503]	-3	hSpCas9	negative selection	7090943
48921740	48921763	18	+	27260156	K562	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.2702650971662065	[688]	[808,950,573,640]	3	hSpCas9	negative selection	7147939
48950392	48950415	18	-	27260156	K562	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.5026152401682519	[597]	[739,604,1119,553]	6	hSpCas9	negative selection	7147940
48949811	48949834	18	-	27260156	K562	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	0.06515918668745657	[958]	[830,965,701,1039]	0	hSpCas9	negative selection	7147941
48921868	48921891	18	+	27260156	K562	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.4615939116297947	[1739]	[1087,1222,1049,1121]	-5	hSpCas9	negative selection	7212192
48942474	48942497	18	+	27260156	K562	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	-0.21291041649615228	[560]	[307,584,518,315]	-3	hSpCas9	negative selection	7212193
48942516	48942539	18	-	27260156	K562	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.03002685690519559	[511]	[449,422,537,441]	0	hSpCas9	negative selection	7212194
48921740	48921763	18	+	27260156	HT29	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.3766133836196648	[688]	[1180,1085,1023,1060]	7	hSpCas9	negative selection	7269190
48950392	48950415	18	-	27260156	HT29	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.3428564044278788	[597]	[739,985,1162,798]	6	hSpCas9	negative selection	7269191
48949811	48949834	18	-	27260156	HT29	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.16460823694634974	[958]	[1125,1406,915,774]	-3	hSpCas9	negative selection	7269192
48921868	48921891	18	+	27260156	HT29	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	0.020182815875939175	[1739]	[2301,2400,2178,1763]	0	hSpCas9	negative selection	7333443
48942474	48942497	18	+	27260156	HT29	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.2798925918060571	[560]	[801,871,862,776]	5	hSpCas9	negative selection	7333444
48942516	48942539	18	-	27260156	HT29	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.43701888758697705	[511]	[891,1050,654,793]	8	hSpCas9	negative selection	7333445
48921740	48921763	18	+	27260156	MHHES1	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.38062544012200983	[688]	[947,1227,920,948]	6	hSpCas9	negative selection	7390441
48950392	48950415	18	-	27260156	MHHES1	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.020523367829008765	[597]	[873,499,764,601]	0	hSpCas9	negative selection	7390442
48949811	48949834	18	-	27260156	MHHES1	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.2576164137823298	[958]	[1285,938,880,606]	-5	hSpCas9	negative selection	7390443
48921868	48921891	18	+	27260156	MHHES1	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	0.15323523438755826	[1739]	[2927,1999,2310,1630]	3	hSpCas9	negative selection	7454694
48942474	48942497	18	+	27260156	MHHES1	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.19845167185414148	[560]	[913,841,556,626]	3	hSpCas9	negative selection	7454695
48942516	48942539	18	-	27260156	MHHES1	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.1822569779795103	[511]	[712,797,652,496]	3	hSpCas9	negative selection	7454696
48921740	48921763	18	+	27260156	MEWO	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.2703740591092745	[688]	[868,769,710]	6	hSpCas9	negative selection	7511692
48950392	48950415	18	-	27260156	MEWO	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.11720745994664661	[597]	[701,555,580]	2	hSpCas9	negative selection	7511693
48949811	48949834	18	-	27260156	MEWO	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	0.14093229636997395	[958]	[1185,929,889]	3	hSpCas9	negative selection	7511694
48921868	48921891	18	+	27260156	MEWO	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.1977348388785778	[1739]	[1602,1293,1396]	-4	hSpCas9	negative selection	7575945
48942474	48942497	18	+	27260156	MEWO	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	-0.2636835941864612	[560]	[587,366,385]	-5	hSpCas9	negative selection	7575946
48942516	48942539	18	-	27260156	MEWO	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.04275064340741329	[511]	[609,435,456]	1	hSpCas9	negative selection	7575947
48921740	48921763	18	+	27260156	LNCAPCLONEFGC	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.5222756211987669	[688]	[867,925,831,947]	7	hSpCas9	negative selection	7632943
48950392	48950415	18	-	27260156	LNCAPCLONEFGC	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.4934441216480635	[597]	[708,852,782,702]	7	hSpCas9	negative selection	7632944
48949811	48949834	18	-	27260156	LNCAPCLONEFGC	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.1177341490095275	[958]	[602,888,712,981]	-2	hSpCas9	negative selection	7632945
48921868	48921891	18	+	27260156	LNCAPCLONEFGC	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	0.048718547160143455	[1739]	[1532,1465,2088,1512]	0	hSpCas9	negative selection	7697196
48942474	48942497	18	+	27260156	LNCAPCLONEFGC	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.051409902254770545	[560]	[612,538,481,462]	0	hSpCas9	negative selection	7697197
48942516	48942539	18	-	27260156	LNCAPCLONEFGC	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.17646154554323412	[511]	[420,565,601,517]	2	hSpCas9	negative selection	7697198
48921740	48921763	18	+	27260156	PANC0327	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	-0.05736369793128093	[688]	[866,518,385,611]	-1	hSpCas9	negative selection	7754194
48950392	48950415	18	-	27260156	PANC0327	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.42071432512159646	[597]	[594,577,898,779]	6	hSpCas9	negative selection	7754195
48949811	48949834	18	-	27260156	PANC0327	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	0.166680807321836	[958]	[758,849,983,1228]	2	hSpCas9	negative selection	7754196
48921868	48921891	18	+	27260156	PANC0327	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	0.35340935983701005	[1739]	[2096,2273,1607,1889]	5	hSpCas9	negative selection	7818447
48942474	48942497	18	+	27260156	PANC0327	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	-0.16434796707508748	[560]	[514,309,570,405]	-2	hSpCas9	negative selection	7818448
48942516	48942539	18	-	27260156	PANC0327	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.24430853424426813	[511]	[454,483,581,633]	3	hSpCas9	negative selection	7818449
48921740	48921763	18	+	27260156	NCIH2009	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.3359889803110947	[688]	[1485,1200,1009]	4	hSpCas9	negative selection	7875445
48950392	48950415	18	-	27260156	NCIH2009	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.7322635951233643	[597]	[1305,1351,1487]	8	hSpCas9	negative selection	7875446
48949811	48949834	18	-	27260156	NCIH2009	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.04422330231632088	[958]	[1519,1225,1194]	0	hSpCas9	negative selection	7875447
48921868	48921891	18	+	27260156	NCIH2009	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.0011119008789759466	[1739]	[3146,2059,2224]	0	hSpCas9	negative selection	7939698
48942474	48942497	18	+	27260156	NCIH2009	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.3257671679372883	[560]	[1293,983,728]	4	hSpCas9	negative selection	7939699
48942516	48942539	18	-	27260156	NCIH2009	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.3719088892272215	[511]	[1368,823,671]	5	hSpCas9	negative selection	7939700
48921740	48921763	18	+	27260156	NCIH1373	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.7252392509828864	[688]	[1586,1107,1467,257]	7	hSpCas9	negative selection	7996696
48950392	48950415	18	-	27260156	NCIH1373	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.5926363136157302	[597]	[984,924,1198,242]	6	hSpCas9	negative selection	7996697
48949811	48949834	18	-	27260156	NCIH1373	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	0.4453204491514542	[958]	[2612,1096,1140,316]	4	hSpCas9	negative selection	7996698
48921868	48921891	18	+	27260156	NCIH1373	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	0.13924582508371097	[1739]	[2947,1722,1885,578]	1	hSpCas9	negative selection	8060949
48942474	48942497	18	+	27260156	NCIH1373	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.349232904456791	[560]	[795,738,897,201]	3	hSpCas9	negative selection	8060950
48942516	48942539	18	-	27260156	NCIH1373	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.6259048162418407	[511]	[771,1173,831,183]	6	hSpCas9	negative selection	8060951
48921740	48921763	18	+	27260156	PATU8902	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.44975704797415883	[688]	[1895,1261,965,1172]	4	hSpCas9	negative selection	8117947
48950392	48950415	18	-	27260156	PATU8902	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.8540320646459898	[597]	[992,2411,1340,1289]	8	hSpCas9	negative selection	8117948
48949811	48949834	18	-	27260156	PATU8902	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.40592754643834617	[958]	[713,1102,872,1422]	-4	hSpCas9	negative selection	8117949
48921868	48921891	18	+	27260156	PATU8902	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	0.42225331776002495	[1739]	[3627,3192,2321,4164]	4	hSpCas9	negative selection	8182200
48942474	48942497	18	+	27260156	PATU8902	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	-0.14593491311903062	[560]	[820,617,342,1186]	-1	hSpCas9	negative selection	8182201
48942516	48942539	18	-	27260156	PATU8902	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.6943293806331395	[511]	[1172,974,943,1623]	7	hSpCas9	negative selection	8182202
48921740	48921763	18	+	27260156	PANC1	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.5234321946318445	[688]	[757,1126,975,624]	8	hSpCas9	negative selection	8239198
48950392	48950415	18	-	27260156	PANC1	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.5204917005107877	[597]	[686,842,761,675]	8	hSpCas9	negative selection	8239199
48949811	48949834	18	-	27260156	PANC1	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	0.2568533796940011	[958]	[778,1033,1077,1035]	4	hSpCas9	negative selection	8239200
48921868	48921891	18	+	27260156	PANC1	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	0.12636199279182136	[1739]	[1514,2312,1642,1235]	2	hSpCas9	negative selection	8303451
48942474	48942497	18	+	27260156	PANC1	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.2428865360342049	[560]	[568,811,564,402]	4	hSpCas9	negative selection	8303452
48942516	48942539	18	-	27260156	PANC1	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.762023880443375	[511]	[808,771,734,670]	9	hSpCas9	negative selection	8303453
48921740	48921763	18	+	27260156	PANC0813	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.6202578482839674	[688]	[1259,1098,1332,1281]	8	hSpCas9	negative selection	8360449
48950392	48950415	18	-	27260156	PANC0813	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.48273308764597367	[597]	[1238,872,769,1060]	7	hSpCas9	negative selection	8360450
48949811	48949834	18	-	27260156	PANC0813	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	0.30815231791180464	[958]	[1344,1650,1269,1309]	5	hSpCas9	negative selection	8360451
48921868	48921891	18	+	27260156	PANC0813	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.07257977363206014	[1739]	[1953,1765,2091,1959]	-1	hSpCas9	negative selection	8424702
48942474	48942497	18	+	27260156	PANC0813	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.42086187433779254	[560]	[1070,718,1064,700]	6	hSpCas9	negative selection	8424703
48942516	48942539	18	-	27260156	PANC0813	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.42036611620181685	[511]	[781,792,713,919]	6	hSpCas9	negative selection	8424704
48921740	48921763	18	+	27260156	RDES	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.1398478084150051	[688]	[873,751,910,949]	2	hSpCas9	negative selection	8481700
48950392	48950415	18	-	27260156	RDES	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.0891928315283011	[597]	[694,704,650,880]	1	hSpCas9	negative selection	8481701
48949811	48949834	18	-	27260156	RDES	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.26411323652556373	[958]	[639,847,1040,1239]	-4	hSpCas9	negative selection	8481702
48921868	48921891	18	+	27260156	RDES	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.07682699604293974	[1739]	[1762,1759,2045,2024]	-1	hSpCas9	negative selection	8545953
48942474	48942497	18	+	27260156	RDES	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.008385079881541413	[560]	[601,532,785,685]	0	hSpCas9	negative selection	8545954
48942516	48942539	18	-	27260156	RDES	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.4124476087055666	[511]	[619,732,859,969]	6	hSpCas9	negative selection	8545955
48921740	48921763	18	+	27260156	PC3	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.5303512043054188	[688]	[719,1038,1524,891]	9	hSpCas9	negative selection	8602951
48950392	48950415	18	-	27260156	PC3	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.0008182669831503508	[597]	[499,468,990,551]	0	hSpCas9	negative selection	8602952
48949811	48949834	18	-	27260156	PC3	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.011829275281572738	[958]	[716,1011,1452,786]	0	hSpCas9	negative selection	8602953
48921868	48921891	18	+	27260156	PC3	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.12809616942633895	[1739]	[1017,1376,2908,1667]	-3	hSpCas9	negative selection	8667204
48942474	48942497	18	+	27260156	PC3	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.16867971093935524	[560]	[355,761,1354,367]	4	hSpCas9	negative selection	8667205
48942516	48942539	18	-	27260156	PC3	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.05879202778578514	[511]	[266,641,853,555]	1	hSpCas9	negative selection	8667206
48921740	48921763	18	+	27260156	PATU8988T	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	-0.059747513501257066	[688]	[396,682,918,548]	-1	hSpCas9	negative selection	8724202
48950392	48950415	18	-	27260156	PATU8988T	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	-0.01753696187895082	[597]	[541,712,364,688]	0	hSpCas9	negative selection	8724203
48949811	48949834	18	-	27260156	PATU8988T	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.27919170360248313	[958]	[571,862,719,921]	-5	hSpCas9	negative selection	8724204
48921868	48921891	18	+	27260156	PATU8988T	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.19381811064529741	[1739]	[1610,1726,1187,1373]	-3	hSpCas9	negative selection	8788455
48942474	48942497	18	+	27260156	PATU8988T	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.10386446698020274	[560]	[599,587,471,679]	1	hSpCas9	negative selection	8788456
48942516	48942539	18	-	27260156	PATU8988T	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.1572156156661128	[511]	[528,647,366,684]	2	hSpCas9	negative selection	8788457
48921740	48921763	18	+	27260156	T47D	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.3169099029696979	[688]	[1025,912,979,1090]	6	hSpCas9	negative selection	8845453
48950392	48950415	18	-	27260156	T47D	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.32103102024881636	[597]	[870,710,837,1081]	6	hSpCas9	negative selection	8845454
48949811	48949834	18	-	27260156	T47D	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.0780480507071103	[958]	[1029,947,1150,1113]	-2	hSpCas9	negative selection	8845455
48921868	48921891	18	+	27260156	T47D	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.13711905942294744	[1739]	[1701,1860,1890,1917]	-3	hSpCas9	negative selection	8909706
48942474	48942497	18	+	27260156	T47D	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.13422770361281594	[560]	[732,734,640,760]	3	hSpCas9	negative selection	8909707
48942516	48942539	18	-	27260156	T47D	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.22507090965117255	[511]	[701,648,681,761]	5	hSpCas9	negative selection	8909708
48921740	48921763	18	+	27260156	SU8686	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.5064513155179735	[688]	[760,949,1014,1215]	8	hSpCas9	negative selection	8966704
48950392	48950415	18	-	27260156	SU8686	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.3637089481145551	[597]	[757,762,707,825]	6	hSpCas9	negative selection	8966705
48949811	48949834	18	-	27260156	SU8686	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.12355128979606345	[958]	[794,885,842,984]	-2	hSpCas9	negative selection	8966706
48921868	48921891	18	+	27260156	SU8686	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.17784974983059487	[1739]	[1156,1318,1625,2161]	-3	hSpCas9	negative selection	9030957
48942474	48942497	18	+	27260156	SU8686	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.03602607318792972	[560]	[586,557,567,561]	0	hSpCas9	negative selection	9030958
48942516	48942539	18	-	27260156	SU8686	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.31501452055238915	[511]	[595,655,577,701]	5	hSpCas9	negative selection	9030959
48921740	48921763	18	+	27260156	SKES1	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.23757882034413125	[688]	[811,800,799,817]	5	hSpCas9	negative selection	9087955
48950392	48950415	18	-	27260156	SKES1	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.29958094152859127	[597]	[1050,770,648,531]	6	hSpCas9	negative selection	9087956
48949811	48949834	18	-	27260156	SKES1	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.16675003400666533	[958]	[912,1106,833,613]	-4	hSpCas9	negative selection	9087957
48921868	48921891	18	+	27260156	SKES1	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.13373535728952501	[1739]	[1681,2041,1400,1292]	-3	hSpCas9	negative selection	9152208
48942474	48942497	18	+	27260156	SKES1	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.10966298994977769	[560]	[723,564,478,648]	2	hSpCas9	negative selection	9152209
48942516	48942539	18	-	27260156	SKES1	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.4014892807472441	[511]	[745,754,716,511]	8	hSpCas9	negative selection	9152210
48921740	48921763	18	+	27260156	TOV112D	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.5315131742613217	[688]	[909,1062,1028,994]	8	hSpCas9	negative selection	9209206
48950392	48950415	18	-	27260156	TOV112D	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.1396785287692942	[597]	[603,794,653,614]	2	hSpCas9	negative selection	9209207
48949811	48949834	18	-	27260156	TOV112D	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.11752549761258946	[958]	[709,1237,780,882]	-2	hSpCas9	negative selection	9209208
48921868	48921891	18	+	27260156	TOV112D	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.017265856564654625	[1739]	[1518,2203,1376,1881]	0	hSpCas9	negative selection	9273459
48942474	48942497	18	+	27260156	TOV112D	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.007072589541429419	[560]	[515,816,649,338]	0	hSpCas9	negative selection	9273460
48942516	48942539	18	-	27260156	TOV112D	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.43324449960894207	[511]	[616,752,422,975]	7	hSpCas9	negative selection	9273461
48921740	48921763	18	+	27260156	TC71	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.4042671805464133	[688]	[882,1113,749,1184]	8	hSpCas9	negative selection	9330457
48950392	48950415	18	-	27260156	TC71	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.08030464433401885	[597]	[839,540,699,621]	2	hSpCas9	negative selection	9330458
48949811	48949834	18	-	27260156	TC71	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.10332962787488487	[958]	[1051,853,965,952]	-3	hSpCas9	negative selection	9330459
48921868	48921891	18	+	27260156	TC71	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.14603486420941203	[1739]	[1619,1674,1574,1889]	-4	hSpCas9	negative selection	9394710
48942474	48942497	18	+	27260156	TC71	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.12623261317289214	[560]	[773,552,681,609]	3	hSpCas9	negative selection	9394711
48942516	48942539	18	-	27260156	TC71	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.3586111074766308	[511]	[639,753,764,651]	8	hSpCas9	negative selection	9394712
48921740	48921763	18	+	27260156	TC32	viability	TGTCCGAATTGAGCTGTCCGAGG	SMAD7	ENSG00000101665	0.10186733798162206	[688]	[733,483,929,705]	1	hSpCas9	negative selection	9451708
48950392	48950415	18	-	27260156	TC32	viability	CCAAACGATCTGCGCTCGTCCGG	SMAD7	ENSG00000101665	0.30532059500547326	[597]	[657,561,1018,601]	5	hSpCas9	negative selection	9451709
48949811	48949834	18	-	27260156	TC32	viability	CTTAGCCGACTCTGCGAACTAGG	SMAD7	ENSG00000101665	-0.20695383776635312	[958]	[741,560,941,957]	-4	hSpCas9	negative selection	9451710
48921868	48921891	18	+	27260156	TC32	viability	CACCAGTGTGACCGATCCCCAGG	SMAD7	ENSG00000101665	-0.1831403178312192	[1739]	[1378,1012,1963,1588]	-3	hSpCas9	negative selection	9515961
48942474	48942497	18	+	27260156	TC32	viability	ATCTTACCTGAAAGCCCCCCAGG	SMAD7	ENSG00000101665	0.1287595412460134	[560]	[415,468,819,675]	2	hSpCas9	negative selection	9515962
48942516	48942539	18	-	27260156	TC32	viability	GTGCCTTCCTCCGCTGAAACAGG	SMAD7	ENSG00000101665	0.3630598424674116	[511]	[770,310,869,628]	6	hSpCas9	negative selection	9515963
48921483	48921506	18	-	27869803	HPAFII	viability after 27 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.18954817251514444	[614]	[371,365,NaN]	1	hSpCas9	negative selection	9564662
48921677	48921700	18	-	27869803	HPAFII	viability after 27 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	-0.7264729884016556	[312]	[93,103,NaN]	-5	hSpCas9	negative selection	9564663
48942514	48942537	18	-	27869803	HPAFII	viability after 27 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.008521185435492074	[574]	[344,269,NaN]	0	hSpCas9	negative selection	9564664
48948404	48948427	18	+	27869803	HPAFII	viability after 27 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	-2.1515790831434267	[314]	[51,24,NaN]	-8	hSpCas9	negative selection	9564665
48948406	48948429	18	+	27869803	HPAFII	viability after 27 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	-0.953787397742185	[558]	[184,123,NaN]	-6	hSpCas9	negative selection	9564666
48950213	48950236	18	-	27869803	HPAFII	viability after 27 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	-0.1108936934389323	[151]	[49,93,NaN]	-1	hSpCas9	negative selection	9564667
48921483	48921506	18	-	27869803	HPAFII	viability after 15 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.07298764320794637	[614]	[952,534,NaN]	0	hSpCas9	negative selection	9647111
48921677	48921700	18	-	27869803	HPAFII	viability after 15 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	-0.6341225872348515	[312]	[188,233,NaN]	-6	hSpCas9	negative selection	9647112
48942514	48942537	18	-	27869803	HPAFII	viability after 15 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	-0.7848309777915543	[574]	[518,258,NaN]	-7	hSpCas9	negative selection	9647113
48948404	48948427	18	+	27869803	HPAFII	viability after 15 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	-1.320337410523303	[314]	[121,143,NaN]	-8	hSpCas9	negative selection	9647114
48948406	48948429	18	+	27869803	HPAFII	viability after 15 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	-0.3785656281028035	[558]	[635,353,NaN]	-4	hSpCas9	negative selection	9647115
48950213	48950236	18	-	27869803	HPAFII	viability after 15 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	0.2103406270233189	[151]	[188,188,NaN]	2	hSpCas9	negative selection	9647116
48921483	48921506	18	-	27869803	ASPC1	viability after 36 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.26936403820666865	[1480]	[639,919,368]	2	hSpCas9	negative selection	9729560
48921677	48921700	18	-	27869803	ASPC1	viability after 36 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	0.4222359803520407	[927]	[162,342,691]	4	hSpCas9	negative selection	9729561
48942514	48942537	18	-	27869803	ASPC1	viability after 36 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	-0.014572813578653365	[1280]	[275,429,564]	0	hSpCas9	negative selection	9729562
48948404	48948427	18	+	27869803	ASPC1	viability after 36 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	-0.06426224822094825	[569]	[348,57,181]	0	hSpCas9	negative selection	9729563
48948406	48948429	18	+	27869803	ASPC1	viability after 36 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	-0.16076232897974618	[1222]	[456,492,236]	-2	hSpCas9	negative selection	9729564
48950213	48950236	18	-	27869803	ASPC1	viability after 36 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	-0.14495772858574396	[391]	[3,306,60]	-1	hSpCas9	negative selection	9729565
48921483	48921506	18	-	27869803	PATU8988S	viability after 35 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	-0.14905056512878256	[1539]	[495,622,NaN]	-1	hSpCas9	negative selection	9812009
48921677	48921700	18	-	27869803	PATU8988S	viability after 35 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	0.4446583396075531	[509]	[301,256,NaN]	5	hSpCas9	negative selection	9812010
48942514	48942537	18	-	27869803	PATU8988S	viability after 35 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.2597853088245098	[1072]	[479,554,NaN]	3	hSpCas9	negative selection	9812011
48948404	48948427	18	+	27869803	PATU8988S	viability after 35 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	0.9206818518422117	[403]	[313,301,NaN]	8	hSpCas9	negative selection	9812012
48948406	48948429	18	+	27869803	PATU8988S	viability after 35 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	0.8467038519298941	[1002]	[714,737,NaN]	8	hSpCas9	negative selection	9812013
48950213	48950236	18	-	27869803	PATU8988S	viability after 35 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	0.48586294626778737	[351]	[213,182,NaN]	5	hSpCas9	negative selection	9812014
48921483	48921506	18	-	27869803	PATU8988S	viability after 31 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	-0.2824706831410526	[1539]	[470,547,NaN]	-3	hSpCas9	negative selection	9894458
48921677	48921700	18	-	27869803	PATU8988S	viability after 31 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	0.6349417502839647	[509]	[273,368,NaN]	7	hSpCas9	negative selection	9894459
48942514	48942537	18	-	27869803	PATU8988S	viability after 31 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.051059469269997604	[1072]	[371,533,NaN]	0	hSpCas9	negative selection	9894460
48948404	48948427	18	+	27869803	PATU8988S	viability after 31 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	1.0415401203356773	[403]	[313,353,NaN]	9	hSpCas9	negative selection	9894461
48948406	48948429	18	+	27869803	PATU8988S	viability after 31 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	0.6954639346113481	[1002]	[571,743,NaN]	7	hSpCas9	negative selection	9894462
48950213	48950236	18	-	27869803	PATU8988S	viability after 31 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	0.22211194391708172	[351]	[157,170,NaN]	2	hSpCas9	negative selection	9894463
48921483	48921506	18	-	27869803	HPAFII	viability after 35 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.1253755419942244	[614]	[261,426,NaN]	0	hSpCas9	negative selection	9976907
48921677	48921700	18	-	27869803	HPAFII	viability after 35 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	-1.2986936036643655	[312]	[62,65,NaN]	-6	hSpCas9	negative selection	9976908
48942514	48942537	18	-	27869803	HPAFII	viability after 35 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.12480716596512975	[574]	[283,354,NaN]	0	hSpCas9	negative selection	9976909
48948404	48948427	18	+	27869803	HPAFII	viability after 35 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	-3.23941710839736	[314]	[22,9,NaN]	-8	hSpCas9	negative selection	9976910
48948406	48948429	18	+	27869803	HPAFII	viability after 35 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	-0.7517894483200543	[558]	[168,166,NaN]	-4	hSpCas9	negative selection	9976911
48950213	48950236	18	-	27869803	HPAFII	viability after 35 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	-0.2618350553921712	[151]	[66,60,NaN]	-2	hSpCas9	negative selection	9976912
48921483	48921506	18	-	27869803	HPAFII	viability after 31 days	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.28628678186062584	[614]	[429,410,NaN]	2	hSpCas9	negative selection	10059356
48921677	48921700	18	-	27869803	HPAFII	viability after 31 days	CTGCGGCATCCAGCTGACGCGGG	SMAD7	ENSG00000101665	-1.5362522539159333	[312]	[61,58,NaN]	-7	hSpCas9	negative selection	10059357
48942514	48942537	18	-	27869803	HPAFII	viability after 31 days	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	-0.22858736250572365	[574]	[239,313,NaN]	-1	hSpCas9	negative selection	10059358
48948404	48948427	18	+	27869803	HPAFII	viability after 31 days	ATCGGGTATCTGGAGTAAGGAGG	SMAD7	ENSG00000101665	-3.3207416824106244	[314]	[21,12,NaN]	-9	hSpCas9	negative selection	10059359
48948406	48948429	18	+	27869803	HPAFII	viability after 31 days	CGGGTATCTGGAGTAAGGAGGGG	SMAD7	ENSG00000101665	-1.0586868889464025	[558]	[152,147,NaN]	-6	hSpCas9	negative selection	10059360
48950213	48950236	18	-	27869803	HPAFII	viability after 31 days	AAGGCGGTGCGAGGTGCCAAAGG	SMAD7	ENSG00000101665	-0.6169874197834164	[151]	[35,76,NaN]	-4	hSpCas9	negative selection	10059361
48942514	48942537	18	-	28162770	P31FUJ	viability	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	-1.8717035122463386	[108]	[34]	-8	hSpCas9	negative selection	10238760
48921449	48921472	18	-	28162770	P31FUJ	viability	CGTGCAGATCAGCTTTGTGAAGG	SMAD7	ENSG00000101665	0.4690595887959117	[623]	[1014]	5	hSpCas9	negative selection	10238761
48942492	48942515	18	-	28162770	P31FUJ	viability	GGAACGAATTATCTGGCCCCTGG	SMAD7	ENSG00000101665	0.2739778634920407	[296]	[421]	3	hSpCas9	negative selection	10238762
48921694	48921717	18	-	28162770	P31FUJ	viability	GTGCGGAGCAAAATCGGCTGCGG	SMAD7	ENSG00000101665	0.6561664831968775	[134]	[249]	7	hSpCas9	negative selection	10238763
48921548	48921571	18	+	28162770	P31FUJ	viability	AAGCCTTGATGGAGAAACCGGGG	SMAD7	ENSG00000101665	1.0644638362387147	[58]	[144]	9	hSpCas9	negative selection	10238764
48921828	48921851	18	-	28162770	P31FUJ	viability	AGGAGAAGACGAGAGTGGGGAGG	SMAD7	ENSG00000101665	0.82609148463919	[11]	[24]	8	hSpCas9	negative selection	10238765
48921678	48921701	18	-	28162770	P31FUJ	viability	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	0.09256497443975453	[418]	[524]	0	hSpCas9	negative selection	10238766
48921597	48921620	18	+	28162770	P31FUJ	viability	GGAGTCCGGGTTGTCCAGTGTGG	SMAD7	ENSG00000101665	0.24934949072300205	[125]	[175]	2	hSpCas9	negative selection	10238767
48921516	48921539	18	-	28162770	P31FUJ	viability	AGAAGGCGTACAGCCTGCAGCGG	SMAD7	ENSG00000101665	0.1500548891153155	[101]	[132]	1	hSpCas9	negative selection	10238768
48921483	48921506	18	-	28162770	P31FUJ	viability	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.5983208835761751	[171]	[305]	6	hSpCas9	negative selection	10238769
48942514	48942537	18	-	28162770	TF1	viability	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	NaN	[NaN]	[64]	1	hSpCas9	negative selection	10408126
48921449	48921472	18	-	28162770	TF1	viability	CGTGCAGATCAGCTTTGTGAAGG	SMAD7	ENSG00000101665	NaN	[NaN]	[702]	1	hSpCas9	negative selection	10408127
48942492	48942515	18	-	28162770	TF1	viability	GGAACGAATTATCTGGCCCCTGG	SMAD7	ENSG00000101665	NaN	[NaN]	[982]	1	hSpCas9	negative selection	10408128
48921694	48921717	18	-	28162770	TF1	viability	GTGCGGAGCAAAATCGGCTGCGG	SMAD7	ENSG00000101665	NaN	[NaN]	[87]	1	hSpCas9	negative selection	10408129
48921548	48921571	18	+	28162770	TF1	viability	AAGCCTTGATGGAGAAACCGGGG	SMAD7	ENSG00000101665	NaN	[NaN]	[100]	1	hSpCas9	negative selection	10408130
48921828	48921851	18	-	28162770	TF1	viability	AGGAGAAGACGAGAGTGGGGAGG	SMAD7	ENSG00000101665	NaN	[NaN]	[10]	1	hSpCas9	negative selection	10408131
48921678	48921701	18	-	28162770	TF1	viability	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	NaN	[NaN]	[285]	1	hSpCas9	negative selection	10408132
48921597	48921620	18	+	28162770	TF1	viability	GGAGTCCGGGTTGTCCAGTGTGG	SMAD7	ENSG00000101665	NaN	[NaN]	[88]	1	hSpCas9	negative selection	10408133
48921516	48921539	18	-	28162770	TF1	viability	AGAAGGCGTACAGCCTGCAGCGG	SMAD7	ENSG00000101665	NaN	[NaN]	[324]	1	hSpCas9	negative selection	10408134
48921483	48921506	18	-	28162770	TF1	viability	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	NaN	[NaN]	[106]	1	hSpCas9	negative selection	10408135
48942514	48942537	18	-	28162770	SKM1	viability	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.5994620704162712	[27]	[74]	6	hSpCas9	negative selection	10577492
48921449	48921472	18	-	28162770	SKM1	viability	CGTGCAGATCAGCTTTGTGAAGG	SMAD7	ENSG00000101665	0.6804986425071777	[149]	[424]	6	hSpCas9	negative selection	10577493
48942492	48942515	18	-	28162770	SKM1	viability	GGAACGAATTATCTGGCCCCTGG	SMAD7	ENSG00000101665	0.5613269415295004	[91]	[239]	5	hSpCas9	negative selection	10577494
48921694	48921717	18	-	28162770	SKM1	viability	GTGCGGAGCAAAATCGGCTGCGG	SMAD7	ENSG00000101665	-0.023635559191655997	[45]	[79]	0	hSpCas9	negative selection	10577495
48921548	48921571	18	+	28162770	SKM1	viability	AAGCCTTGATGGAGAAACCGGGG	SMAD7	ENSG00000101665	2.770015560233101	[16]	[204]	9	hSpCas9	negative selection	10577496
48921828	48921851	18	-	28162770	SKM1	viability	AGGAGAAGACGAGAGTGGGGAGG	SMAD7	ENSG00000101665	-0.01464677596440156	[3]	[6]	0	hSpCas9	negative selection	10577497
48921678	48921701	18	-	28162770	SKM1	viability	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	0.9807659545399466	[89]	[313]	8	hSpCas9	negative selection	10577498
48921597	48921620	18	+	28162770	SKM1	viability	GGAGTCCGGGTTGTCCAGTGTGG	SMAD7	ENSG00000101665	0.9038233385390004	[25]	[85]	8	hSpCas9	negative selection	10577499
48921516	48921539	18	-	28162770	SKM1	viability	AGAAGGCGTACAGCCTGCAGCGG	SMAD7	ENSG00000101665	1.4167851615651108	[24]	[117]	9	hSpCas9	negative selection	10577500
48921483	48921506	18	-	28162770	SKM1	viability	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.2795363284400568	[47]	[102]	2	hSpCas9	negative selection	10577501
48942514	48942537	18	-	28162770	SKM1	viability	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.5994620704162712	[27]	[74]	6	hSpCas9	negative selection	10746858
48921449	48921472	18	-	28162770	SKM1	viability	CGTGCAGATCAGCTTTGTGAAGG	SMAD7	ENSG00000101665	0.6804986425071777	[149]	[424]	6	hSpCas9	negative selection	10746859
48942492	48942515	18	-	28162770	SKM1	viability	GGAACGAATTATCTGGCCCCTGG	SMAD7	ENSG00000101665	0.5613269415295004	[91]	[239]	5	hSpCas9	negative selection	10746860
48921694	48921717	18	-	28162770	SKM1	viability	GTGCGGAGCAAAATCGGCTGCGG	SMAD7	ENSG00000101665	-0.023635559191655997	[45]	[79]	0	hSpCas9	negative selection	10746861
48921548	48921571	18	+	28162770	SKM1	viability	AAGCCTTGATGGAGAAACCGGGG	SMAD7	ENSG00000101665	2.770015560233101	[16]	[204]	9	hSpCas9	negative selection	10746862
48921828	48921851	18	-	28162770	SKM1	viability	AGGAGAAGACGAGAGTGGGGAGG	SMAD7	ENSG00000101665	-0.01464677596440156	[3]	[6]	0	hSpCas9	negative selection	10746863
48921678	48921701	18	-	28162770	SKM1	viability	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	0.9807659545399466	[89]	[313]	8	hSpCas9	negative selection	10746864
48921597	48921620	18	+	28162770	SKM1	viability	GGAGTCCGGGTTGTCCAGTGTGG	SMAD7	ENSG00000101665	0.9038233385390004	[25]	[85]	8	hSpCas9	negative selection	10746865
48921516	48921539	18	-	28162770	SKM1	viability	AGAAGGCGTACAGCCTGCAGCGG	SMAD7	ENSG00000101665	1.4167851615651108	[24]	[117]	9	hSpCas9	negative selection	10746866
48921483	48921506	18	-	28162770	SKM1	viability	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.2795363284400568	[47]	[102]	2	hSpCas9	negative selection	10746867
48942514	48942537	18	-	28162770	PL21	viability	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	-0.5989476915846834	[86]	[24]	-4	hSpCas9	negative selection	10916224
48921449	48921472	18	-	28162770	PL21	viability	CGTGCAGATCAGCTTTGTGAAGG	SMAD7	ENSG00000101665	0.3065765505277942	[430]	[231]	2	hSpCas9	negative selection	10916225
48942492	48942515	18	-	28162770	PL21	viability	GGAACGAATTATCTGGCCCCTGG	SMAD7	ENSG00000101665	-0.4155196834547523	[379]	[123]	-3	hSpCas9	negative selection	10916226
48921694	48921717	18	-	28162770	PL21	viability	GTGCGGAGCAAAATCGGCTGCGG	SMAD7	ENSG00000101665	-1.1430049663077377	[136]	[26]	-6	hSpCas9	negative selection	10916227
48921548	48921571	18	+	28162770	PL21	viability	AAGCCTTGATGGAGAAACCGGGG	SMAD7	ENSG00000101665	-0.7384598408465366	[114]	[29]	-5	hSpCas9	negative selection	10916228
48921828	48921851	18	-	28162770	PL21	viability	AGGAGAAGACGAGAGTGGGGAGG	SMAD7	ENSG00000101665	0.20013961448931994	[9]	[4]	1	hSpCas9	negative selection	10916229
48921678	48921701	18	-	28162770	PL21	viability	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	0.5953945015776261	[256]	[168]	5	hSpCas9	negative selection	10916230
48921597	48921620	18	+	28162770	PL21	viability	GGAGTCCGGGTTGTCCAGTGTGG	SMAD7	ENSG00000101665	0.5882100661678945	[80]	[52]	5	hSpCas9	negative selection	10916231
48921516	48921539	18	-	28162770	PL21	viability	AGAAGGCGTACAGCCTGCAGCGG	SMAD7	ENSG00000101665	-0.5470943151307133	[93]	[27]	-4	hSpCas9	negative selection	10916232
48921483	48921506	18	-	28162770	PL21	viability	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.9537017191862212	[120]	[101]	7	hSpCas9	negative selection	10916233
48942514	48942537	18	-	28162770	P31FUJ	viability	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	-1.8717035122463386	[108]	[34]	-8	hSpCas9	negative selection	11085590
48921449	48921472	18	-	28162770	P31FUJ	viability	CGTGCAGATCAGCTTTGTGAAGG	SMAD7	ENSG00000101665	0.4690595887959117	[623]	[1014]	5	hSpCas9	negative selection	11085591
48942492	48942515	18	-	28162770	P31FUJ	viability	GGAACGAATTATCTGGCCCCTGG	SMAD7	ENSG00000101665	0.2739778634920407	[296]	[421]	3	hSpCas9	negative selection	11085592
48921694	48921717	18	-	28162770	P31FUJ	viability	GTGCGGAGCAAAATCGGCTGCGG	SMAD7	ENSG00000101665	0.6561664831968775	[134]	[249]	7	hSpCas9	negative selection	11085593
48921548	48921571	18	+	28162770	P31FUJ	viability	AAGCCTTGATGGAGAAACCGGGG	SMAD7	ENSG00000101665	1.0644638362387147	[58]	[144]	9	hSpCas9	negative selection	11085594
48921828	48921851	18	-	28162770	P31FUJ	viability	AGGAGAAGACGAGAGTGGGGAGG	SMAD7	ENSG00000101665	0.82609148463919	[11]	[24]	8	hSpCas9	negative selection	11085595
48921678	48921701	18	-	28162770	P31FUJ	viability	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	0.09256497443975453	[418]	[524]	0	hSpCas9	negative selection	11085596
48921597	48921620	18	+	28162770	P31FUJ	viability	GGAGTCCGGGTTGTCCAGTGTGG	SMAD7	ENSG00000101665	0.24934949072300205	[125]	[175]	2	hSpCas9	negative selection	11085597
48921516	48921539	18	-	28162770	P31FUJ	viability	AGAAGGCGTACAGCCTGCAGCGG	SMAD7	ENSG00000101665	0.1500548891153155	[101]	[132]	1	hSpCas9	negative selection	11085598
48921483	48921506	18	-	28162770	P31FUJ	viability	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.5983208835761751	[171]	[305]	6	hSpCas9	negative selection	11085599
48942514	48942537	18	-	28162770	OCIAML5	viability	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.14793342913600305	[45]	[91]	1	hSpCas9	negative selection	11254956
48921449	48921472	18	-	28162770	OCIAML5	viability	CGTGCAGATCAGCTTTGTGAAGG	SMAD7	ENSG00000101665	0.5206601235568824	[345]	[895]	4	hSpCas9	negative selection	11254957
48942492	48942515	18	-	28162770	OCIAML5	viability	GGAACGAATTATCTGGCCCCTGG	SMAD7	ENSG00000101665	0.49956175823878535	[124]	[318]	4	hSpCas9	negative selection	11254958
48921694	48921717	18	-	28162770	OCIAML5	viability	GTGCGGAGCAAAATCGGCTGCGG	SMAD7	ENSG00000101665	-0.3545669113931803	[101]	[143]	-3	hSpCas9	negative selection	11254959
48921548	48921571	18	+	28162770	OCIAML5	viability	AAGCCTTGATGGAGAAACCGGGG	SMAD7	ENSG00000101665	0.20526660420195464	[36]	[76]	1	hSpCas9	negative selection	11254960
48921828	48921851	18	-	28162770	OCIAML5	viability	AGGAGAAGACGAGAGTGGGGAGG	SMAD7	ENSG00000101665	-0.17399466575135936	[4]	[7]	-1	hSpCas9	negative selection	11254961
48921678	48921701	18	-	28162770	OCIAML5	viability	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	0.8519486015009223	[154]	[504]	7	hSpCas9	negative selection	11254962
48921597	48921620	18	+	28162770	OCIAML5	viability	GGAGTCCGGGTTGTCCAGTGTGG	SMAD7	ENSG00000101665	-0.5389086856043666	[65]	[81]	-4	hSpCas9	negative selection	11254963
48921516	48921539	18	-	28162770	OCIAML5	viability	AGAAGGCGTACAGCCTGCAGCGG	SMAD7	ENSG00000101665	0.1265597783434359	[67]	[133]	1	hSpCas9	negative selection	11254964
48921483	48921506	18	-	28162770	OCIAML5	viability	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	2.4232114307245443	[43]	[425]	9	hSpCas9	negative selection	11254965
48942514	48942537	18	-	28162770	EOL1	viability	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.500577147521683	[215]	[160]	4	hSpCas9	negative selection	11424322
48921449	48921472	18	-	28162770	EOL1	viability	CGTGCAGATCAGCTTTGTGAAGG	SMAD7	ENSG00000101665	-0.3973803233168277	[614]	[245]	-3	hSpCas9	negative selection	11424323
48942492	48942515	18	-	28162770	EOL1	viability	GGAACGAATTATCTGGCCCCTGG	SMAD7	ENSG00000101665	0.1255118060435334	[561]	[322]	1	hSpCas9	negative selection	11424324
48921694	48921717	18	-	28162770	EOL1	viability	GTGCGGAGCAAAATCGGCTGCGG	SMAD7	ENSG00000101665	1.1895199816458208	[247]	[297]	8	hSpCas9	negative selection	11424325
48921548	48921571	18	+	28162770	EOL1	viability	AAGCCTTGATGGAGAAACCGGGG	SMAD7	ENSG00000101665	0.0630676356519626	[128]	[70]	0	hSpCas9	negative selection	11424326
48921828	48921851	18	-	28162770	EOL1	viability	AGGAGAAGACGAGAGTGGGGAGG	SMAD7	ENSG00000101665	-3.3973803233168276	[19]	[0]	-9	hSpCas9	negative selection	11424327
48921678	48921701	18	-	28162770	EOL1	viability	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	1.3692482485791926	[348]	[474]	9	hSpCas9	negative selection	11424328
48921597	48921620	18	+	28162770	EOL1	viability	GGAGTCCGGGTTGTCCAGTGTGG	SMAD7	ENSG00000101665	-1.2598767995668931	[149]	[32]	-7	hSpCas9	negative selection	11424329
48921516	48921539	18	-	28162770	EOL1	viability	AGAAGGCGTACAGCCTGCAGCGG	SMAD7	ENSG00000101665	1.443657724997065	[126]	[181]	9	hSpCas9	negative selection	11424330
48921483	48921506	18	-	28162770	EOL1	viability	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	-0.4255509960079885	[180]	[70]	-3	hSpCas9	negative selection	11424331
48942514	48942537	18	-	28162770	MOLM13	viability	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.6156430019882708	[101]	[112]	4	hSpCas9	negative selection	11593688
48921449	48921472	18	-	28162770	MOLM13	viability	CGTGCAGATCAGCTTTGTGAAGG	SMAD7	ENSG00000101665	-0.04668379128517941	[769]	[538]	0	hSpCas9	negative selection	11593689
48942492	48942515	18	-	28162770	MOLM13	viability	GGAACGAATTATCTGGCCCCTGG	SMAD7	ENSG00000101665	0.9068300673499093	[418]	[567]	7	hSpCas9	negative selection	11593690
48921694	48921717	18	-	28162770	MOLM13	viability	GTGCGGAGCAAAATCGGCTGCGG	SMAD7	ENSG00000101665	0.374174946722385	[158]	[148]	2	hSpCas9	negative selection	11593691
48921548	48921571	18	+	28162770	MOLM13	viability	AAGCCTTGATGGAGAAACCGGGG	SMAD7	ENSG00000101665	2.136997888465653	[110]	[352]	9	hSpCas9	negative selection	11593692
48921828	48921851	18	-	28162770	MOLM13	viability	AGGAGAAGACGAGAGTGGGGAGG	SMAD7	ENSG00000101665	0.7088974810483739	[10]	[12]	5	hSpCas9	negative selection	11593693
48921678	48921701	18	-	28162770	MOLM13	viability	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	0.383355871332911	[368]	[347]	3	hSpCas9	negative selection	11593694
48921597	48921620	18	+	28162770	MOLM13	viability	GGAGTCCGGGTTGTCCAGTGTGG	SMAD7	ENSG00000101665	0.21009162407693216	[109]	[91]	1	hSpCas9	negative selection	11593695
48921516	48921539	18	-	28162770	MOLM13	viability	AGAAGGCGTACAGCCTGCAGCGG	SMAD7	ENSG00000101665	-0.4020500778910483	[158]	[86]	-2	hSpCas9	negative selection	11593696
48921483	48921506	18	-	28162770	MOLM13	viability	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.7958162170533842	[191]	[240]	6	hSpCas9	negative selection	11593697
48942514	48942537	18	-	28162770	HEL	viability	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	-0.630279662406059	[144]	[59]	-4	hSpCas9	negative selection	11763054
48921449	48921472	18	-	28162770	HEL	viability	CGTGCAGATCAGCTTTGTGAAGG	SMAD7	ENSG00000101665	0.5512945708029906	[634]	[595]	4	hSpCas9	negative selection	11763055
48942492	48942515	18	-	28162770	HEL	viability	GGAACGAATTATCTGGCCCCTGG	SMAD7	ENSG00000101665	0.8813963076995892	[377]	[445]	7	hSpCas9	negative selection	11763056
48921694	48921717	18	-	28162770	HEL	viability	GTGCGGAGCAAAATCGGCTGCGG	SMAD7	ENSG00000101665	0.8724360539600382	[196]	[230]	7	hSpCas9	negative selection	11763057
48921548	48921571	18	+	28162770	HEL	viability	AAGCCTTGATGGAGAAACCGGGG	SMAD7	ENSG00000101665	-0.06537189949366395	[164]	[100]	0	hSpCas9	negative selection	11763058
48921828	48921851	18	-	28162770	HEL	viability	AGGAGAAGACGAGAGTGGGGAGG	SMAD7	ENSG00000101665	1.505235308250422	[10]	[19]	9	hSpCas9	negative selection	11763059
48921678	48921701	18	-	28162770	HEL	viability	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	-0.48363845376919845	[309]	[141]	-3	hSpCas9	negative selection	11763060
48921597	48921620	18	+	28162770	HEL	viability	GGAGTCCGGGTTGTCCAGTGTGG	SMAD7	ENSG00000101665	-0.49191069469442494	[100]	[45]	-3	hSpCas9	negative selection	11763061
48921516	48921539	18	-	28162770	HEL	viability	AGAAGGCGTACAGCCTGCAGCGG	SMAD7	ENSG00000101665	0.48746060652244594	[97]	[87]	4	hSpCas9	negative selection	11763062
48921483	48921506	18	-	28162770	HEL	viability	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.1352550839569181	[144]	[101]	1	hSpCas9	negative selection	11763063
48942514	48942537	18	-	28162770	MV411	viability	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	-0.8006567374182697	[121]	[58]	-5	hSpCas9	negative selection	11932420
48921449	48921472	18	-	28162770	MV411	viability	CGTGCAGATCAGCTTTGTGAAGG	SMAD7	ENSG00000101665	0.16017823567242084	[442]	[416]	1	hSpCas9	negative selection	11932421
48942492	48942515	18	-	28162770	MV411	viability	GGAACGAATTATCTGGCCCCTGG	SMAD7	ENSG00000101665	0.394695642058444	[334]	[370]	3	hSpCas9	negative selection	11932422
48921694	48921717	18	-	28162770	MV411	viability	GTGCGGAGCAAAATCGGCTGCGG	SMAD7	ENSG00000101665	0.23815973719476455	[155]	[154]	2	hSpCas9	negative selection	11932423
48921548	48921571	18	+	28162770	MV411	viability	AAGCCTTGATGGAGAAACCGGGG	SMAD7	ENSG00000101665	-1.2317302859157842	[91]	[32]	-7	hSpCas9	negative selection	11932424
48921828	48921851	18	-	28162770	MV411	viability	AGGAGAAGACGAGAGTGGGGAGG	SMAD7	ENSG00000101665	0.09543445733772504	[9]	[8]	0	hSpCas9	negative selection	11932425
48921678	48921701	18	-	28162770	MV411	viability	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	-0.012358480984473785	[266]	[222]	0	hSpCas9	negative selection	11932426
48921597	48921620	18	+	28162770	MV411	viability	GGAGTCCGGGTTGTCCAGTGTGG	SMAD7	ENSG00000101665	0.3497992684124531	[67]	[72]	3	hSpCas9	negative selection	11932427
48921516	48921539	18	-	28162770	MV411	viability	AGAAGGCGTACAGCCTGCAGCGG	SMAD7	ENSG00000101665	-1.5735923081719057	[105]	[29]	-7	hSpCas9	negative selection	11932428
48921483	48921506	18	-	28162770	MV411	viability	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.8784697001999167	[112]	[174]	7	hSpCas9	negative selection	11932429
48942514	48942537	18	-	28162770	MONOMAC1	viability	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.3950854452344688	[66]	[100]	4	hSpCas9	negative selection	12101786
48921449	48921472	18	-	28162770	MONOMAC1	viability	CGTGCAGATCAGCTTTGTGAAGG	SMAD7	ENSG00000101665	0.5489175303339073	[287]	[482]	5	hSpCas9	negative selection	12101787
48942492	48942515	18	-	28162770	MONOMAC1	viability	GGAACGAATTATCTGGCCCCTGG	SMAD7	ENSG00000101665	0.6609441480680185	[239]	[434]	6	hSpCas9	negative selection	12101788
48921694	48921717	18	-	28162770	MONOMAC1	viability	GTGCGGAGCAAAATCGGCTGCGG	SMAD7	ENSG00000101665	-1.0645865510359043	[103]	[56]	-7	hSpCas9	negative selection	12101789
48921548	48921571	18	+	28162770	MONOMAC1	viability	AAGCCTTGATGGAGAAACCGGGG	SMAD7	ENSG00000101665	-0.7221278918033114	[58]	[40]	-5	hSpCas9	negative selection	12101790
48921828	48921851	18	-	28162770	MONOMAC1	viability	AGGAGAAGACGAGAGTGGGGAGG	SMAD7	ENSG00000101665	-2.78199934778071	[5]	[0]	-9	hSpCas9	negative selection	12101791
48921678	48921701	18	-	28162770	MONOMAC1	viability	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	0.6266403802999834	[112]	[199]	6	hSpCas9	negative selection	12101792
48921597	48921620	18	+	28162770	MONOMAC1	viability	GGAGTCCGGGTTGTCCAGTGTGG	SMAD7	ENSG00000101665	-0.16227142889887702	[81]	[83]	-1	hSpCas9	negative selection	12101793
48921516	48921539	18	-	28162770	MONOMAC1	viability	AGAAGGCGTACAGCCTGCAGCGG	SMAD7	ENSG00000101665	0.13901235607246143	[60]	[76]	1	hSpCas9	negative selection	12101794
48921483	48921506	18	-	28162770	MONOMAC1	viability	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.3571633998909154	[78]	[115]	3	hSpCas9	negative selection	12101795
48942514	48942537	18	-	28162770	OCIAML2	viability	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	0.8023886691642549	[14]	[144]	7	hSpCas9	negative selection	12271152
48921449	48921472	18	-	28162770	OCIAML2	viability	CGTGCAGATCAGCTTTGTGAAGG	SMAD7	ENSG00000101665	0.6527525902631208	[90]	[792]	6	hSpCas9	negative selection	12271153
48942492	48942515	18	-	28162770	OCIAML2	viability	GGAACGAATTATCTGGCCCCTGG	SMAD7	ENSG00000101665	0.840327151824198	[65]	[654]	7	hSpCas9	negative selection	12271154
48921694	48921717	18	-	28162770	OCIAML2	viability	GTGCGGAGCAAAATCGGCTGCGG	SMAD7	ENSG00000101665	0.4012138232671565	[24]	[182]	4	hSpCas9	negative selection	12271155
48921548	48921571	18	+	28162770	OCIAML2	viability	AAGCCTTGATGGAGAAACCGGGG	SMAD7	ENSG00000101665	0.3773670813127889	[19]	[143]	3	hSpCas9	negative selection	12271156
48921828	48921851	18	-	28162770	OCIAML2	viability	AGGAGAAGACGAGAGTGGGGAGG	SMAD7	ENSG00000101665	-4.0555923259633175	[2]	[0]	-9	hSpCas9	negative selection	12271157
48921678	48921701	18	-	28162770	OCIAML2	viability	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	0.604658302062076	[48]	[412]	6	hSpCas9	negative selection	12271158
48921597	48921620	18	+	28162770	OCIAML2	viability	GGAGTCCGGGTTGTCCAGTGTGG	SMAD7	ENSG00000101665	-1.5637392296336428	[23]	[44]	-7	hSpCas9	negative selection	12271159
48921516	48921539	18	-	28162770	OCIAML2	viability	AGAAGGCGTACAGCCTGCAGCGG	SMAD7	ENSG00000101665	2.1482800074023323	[6]	[171]	9	hSpCas9	negative selection	12271160
48921483	48921506	18	-	28162770	OCIAML2	viability	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.36587144247495906	[13]	[99]	3	hSpCas9	negative selection	12271161
48942514	48942537	18	-	28162770	OCIAML3	viability	GCCTTCCTCCGCTGAAACAGGGG	SMAD7	ENSG00000101665	-0.5521874646295362	[50]	[104]	-4	hSpCas9	negative selection	12440518
48921449	48921472	18	-	28162770	OCIAML3	viability	CGTGCAGATCAGCTTTGTGAAGG	SMAD7	ENSG00000101665	0.79266763587782	[121]	[637]	7	hSpCas9	negative selection	12440519
48942492	48942515	18	-	28162770	OCIAML3	viability	GGAACGAATTATCTGGCCCCTGG	SMAD7	ENSG00000101665	-0.22882634748291708	[91]	[236]	-2	hSpCas9	negative selection	12440520
48921694	48921717	18	-	28162770	OCIAML3	viability	GTGCGGAGCAAAATCGGCTGCGG	SMAD7	ENSG00000101665	-0.8503473935839488	[42]	[71]	-6	hSpCas9	negative selection	12440521
48921548	48921571	18	+	28162770	OCIAML3	viability	AAGCCTTGATGGAGAAACCGGGG	SMAD7	ENSG00000101665	0.7810317910227618	[15]	[82]	7	hSpCas9	negative selection	12440522
48921828	48921851	18	-	28162770	OCIAML3	viability	AGGAGAAGACGAGAGTGGGGAGG	SMAD7	ENSG00000101665	-1.2720795454368008	[3]	[4]	-7	hSpCas9	negative selection	12440523
48921678	48921701	18	-	28162770	OCIAML3	viability	GCTGCGGCATCCAGCTGACGCGG	SMAD7	ENSG00000101665	1.6566617713933773	[82]	[789]	9	hSpCas9	negative selection	12440524
48921597	48921620	18	+	28162770	OCIAML3	viability	GGAGTCCGGGTTGTCCAGTGTGG	SMAD7	ENSG00000101665	0.913786999874533	[31]	[181]	7	hSpCas9	negative selection	12440525
48921516	48921539	18	-	28162770	OCIAML3	viability	AGAAGGCGTACAGCCTGCAGCGG	SMAD7	ENSG00000101665	0.3349092616143543	[25]	[98]	3	hSpCas9	negative selection	12440526
48921483	48921506	18	-	28162770	OCIAML3	viability	ACGAGTTTATGCAGCAGCCGTGG	SMAD7	ENSG00000101665	0.19653899404688724	[36]	[127]	1	hSpCas9	negative selection	12440527