Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:23032
• Symbol:USP33
• Description:ubiquitin specific peptidase 33

DataSource: http://genomecrispr.dkfz.de/#!/results/USP33

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
77725669	77725692	1	+	26472758	Jiyoye	viability	GGAGGGCTTGCCGATAAACGTGG	USP33	ENSG00000077254	1.53645839845084	[31]	[69]	8	hSpCas9	negative selection	178474
77736055	77736078	1	-	26472758	Jiyoye	viability	GAAGATGAACTTAGGGCCAGAGG	USP33	ENSG00000077254	0.8596875862033801	[94]	[129]	6	hSpCas9	negative selection	178475
77722053	77722076	1	-	26472758	Jiyoye	viability	AAGCATATGCTCCACAAGGGTGG	USP33	ENSG00000077254	0.7911859851640927	[140]	[183]	5	hSpCas9	negative selection	178476
77741375	77741398	1	-	26472758	Jiyoye	viability	AAATCTTTGGGCATGTCTGGAGG	USP33	ENSG00000077254	0.8926022086761154	[29]	[41]	6	hSpCas9	negative selection	178477
77739364	77739387	1	+	26472758	Jiyoye	viability	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	-1.1489322565430977	[296]	[100]	-7	hSpCas9	negative selection	178478
77729915	77729938	1	+	26472758	Jiyoye	viability	GTAGTAGGCACAACAGATCCTGG	USP33	ENSG00000077254	0.19849689462129994	[348]	[301]	1	hSpCas9	negative selection	178479
77723330	77723353	1	-	26472758	Jiyoye	viability	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	-0.3737073291905397	[566]	[329]	-3	hSpCas9	negative selection	178480
77717926	77717949	1	+	26472758	Jiyoye	viability	GGACTATCCTTAGCAAGAAATGG	USP33	ENSG00000077254	-0.4274010092867549	[213]	[119]	-3	hSpCas9	negative selection	178481
77714767	77714790	1	-	26472758	Jiyoye	viability	TAATAGGAAGAGCAGCGAAGAGG	USP33	ENSG00000077254	0.3740085175706741	[87]	[85]	3	hSpCas9	negative selection	178482
77711794	77711817	1	-	26472758	Jiyoye	viability	TCATACTTGCCAAATTGAGGCGG	USP33	ENSG00000077254	1.5342872994092127	[37]	[82]	8	hSpCas9	negative selection	178483
77725669	77725692	1	+	26472758	KBM7	viability	GGAGGGCTTGCCGATAAACGTGG	USP33	ENSG00000077254	-0.28163883152099844	[298,307]	[105,128]	-3	hSpCas9	negative selection	369592
77736055	77736078	1	-	26472758	KBM7	viability	GAAGATGAACTTAGGGCCAGAGG	USP33	ENSG00000077254	0.4138851268722637	[537,413]	[339,255]	4	hSpCas9	negative selection	369593
77722053	77722076	1	-	26472758	KBM7	viability	AAGCATATGCTCCACAAGGGTGG	USP33	ENSG00000077254	-0.046477366161863154	[990,644]	[343,385]	0	hSpCas9	negative selection	369594
77741375	77741398	1	-	26472758	KBM7	viability	AAATCTTTGGGCATGTCTGGAGG	USP33	ENSG00000077254	0.38019064141386605	[328,179]	[220,89]	4	hSpCas9	negative selection	369595
77739364	77739387	1	+	26472758	KBM7	viability	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	-0.650408905214998	[696,542]	[131,230]	-5	hSpCas9	negative selection	369596
77729915	77729938	1	+	26472758	KBM7	viability	GTAGTAGGCACAACAGATCCTGG	USP33	ENSG00000077254	0.4005548159252721	[1363,1179]	[872,710]	4	hSpCas9	negative selection	369597
77723330	77723353	1	-	26472758	KBM7	viability	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	0.20014356133844102	[1817,1841]	[805,1161]	2	hSpCas9	negative selection	369598
77717926	77717949	1	+	26472758	KBM7	viability	GGACTATCCTTAGCAAGAAATGG	USP33	ENSG00000077254	-0.041057767987211724	[601,843]	[409,272]	0	hSpCas9	negative selection	369599
77714767	77714790	1	-	26472758	KBM7	viability	TAATAGGAAGAGCAGCGAAGAGG	USP33	ENSG00000077254	0.4640718554616729	[302,325]	[323,99]	5	hSpCas9	negative selection	369600
77711794	77711817	1	-	26472758	KBM7	viability	TCATACTTGCCAAATTGAGGCGG	USP33	ENSG00000077254	-0.6838673444413649	[472,443]	[135,132]	-5	hSpCas9	negative selection	369601
77725669	77725692	1	+	26472758	Raji	viability	GGAGGGCTTGCCGATAAACGTGG	USP33	ENSG00000077254	0.7761776268982264	[77]	[30]	7	hSpCas9	negative selection	560710
77736055	77736078	1	-	26472758	Raji	viability	GAAGATGAACTTAGGGCCAGAGG	USP33	ENSG00000077254	0.5602643857971159	[300]	[102]	5	hSpCas9	negative selection	560711
77722053	77722076	1	-	26472758	Raji	viability	AAGCATATGCTCCACAAGGGTGG	USP33	ENSG00000077254	0.22971907829765148	[451]	[122]	2	hSpCas9	negative selection	560712
77741375	77741398	1	-	26472758	Raji	viability	AAATCTTTGGGCATGTCTGGAGG	USP33	ENSG00000077254	0.68654041441355	[82]	[30]	6	hSpCas9	negative selection	560713
77739364	77739387	1	+	26472758	Raji	viability	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	0.5476215887775858	[226]	[76]	5	hSpCas9	negative selection	560714
77729915	77729938	1	+	26472758	Raji	viability	GTAGTAGGCACAACAGATCCTGG	USP33	ENSG00000077254	0.32977595671004756	[527]	[153]	3	hSpCas9	negative selection	560715
77723330	77723353	1	-	26472758	Raji	viability	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	-0.25904401968062274	[855]	[165]	-2	hSpCas9	negative selection	560716
77717926	77717949	1	+	26472758	Raji	viability	GGACTATCCTTAGCAAGAAATGG	USP33	ENSG00000077254	-0.9002162804845613	[570]	[70]	-6	hSpCas9	negative selection	560717
77714767	77714790	1	-	26472758	Raji	viability	TAATAGGAAGAGCAGCGAAGAGG	USP33	ENSG00000077254	0.785455440486237	[164]	[65]	7	hSpCas9	negative selection	560718
77711794	77711817	1	-	26472758	Raji	viability	TCATACTTGCCAAATTGAGGCGG	USP33	ENSG00000077254	1.1359526875703703	[199]	[101]	8	hSpCas9	negative selection	560719
77725669	77725692	1	+	26472758	K562	viability	GGAGGGCTTGCCGATAAACGTGG	USP33	ENSG00000077254	-1.406132114682286	[269]	[85]	-6	hSpCas9	negative selection	751828
77736055	77736078	1	-	26472758	K562	viability	GAAGATGAACTTAGGGCCAGAGG	USP33	ENSG00000077254	1.1690113250084244	[323]	[614]	8	hSpCas9	negative selection	751829
77722053	77722076	1	-	26472758	K562	viability	AAGCATATGCTCCACAAGGGTGG	USP33	ENSG00000077254	0.551717519929252	[673]	[833]	4	hSpCas9	negative selection	751830
77741375	77741398	1	-	26472758	K562	viability	AAATCTTTGGGCATGTCTGGAGG	USP33	ENSG00000077254	0.12561129762641693	[252]	[232]	0	hSpCas9	negative selection	751831
77739364	77739387	1	+	26472758	K562	viability	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	0.544312310910894	[540]	[665]	4	hSpCas9	negative selection	751832
77729915	77729938	1	+	26472758	K562	viability	GTAGTAGGCACAACAGATCCTGG	USP33	ENSG00000077254	0.2552356108855982	[1062]	[1070]	2	hSpCas9	negative selection	751833
77723330	77723353	1	-	26472758	K562	viability	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	0.3338336485001867	[1563]	[1663]	2	hSpCas9	negative selection	751834
77717926	77717949	1	+	26472758	K562	viability	GGACTATCCTTAGCAAGAAATGG	USP33	ENSG00000077254	0.30271736823111395	[775]	[807]	2	hSpCas9	negative selection	751835
77714767	77714790	1	-	26472758	K562	viability	TAATAGGAAGAGCAGCGAAGAGG	USP33	ENSG00000077254	0.7187151090247019	[315]	[438]	6	hSpCas9	negative selection	751836
77711794	77711817	1	-	26472758	K562	viability	TCATACTTGCCAAATTGAGGCGG	USP33	ENSG00000077254	0.0774763508979921	[301]	[268]	0	hSpCas9	negative selection	751837
77711820	77711843	1	+	26627737	DLD1	viability	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	0.3021581733874053	[335]	[111,81,183]	3	hSpCas9	negative selection	772653
77714652	77714675	1	-	26627737	DLD1	viability	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	0.8383825669087344	[453]	[281,241,238]	7	hSpCas9	negative selection	772654
77722057	77722080	1	-	26627737	DLD1	viability	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	0.2167703314945355	[207]	[103,66,57]	2	hSpCas9	negative selection	772655
77723330	77723353	1	-	26627737	DLD1	viability	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	-0.2807522643415665	[1243]	[432,195,324]	-3	hSpCas9	negative selection	772656
77725645	77725668	1	-	26627737	DLD1	viability	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	1.1182397372503878	[174]	[141,75,133]	8	hSpCas9	negative selection	772657
77736100	77736123	1	+	26627737	DLD1	viability	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	-0.31395732435040014	[757]	[260,171,144]	-3	hSpCas9	negative selection	772658
77711820	77711843	1	+	26627737	GBM cells	viability after 5 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	-0.18970051228788265	[234]	[85,134]	-3	hSpCas9	negative selection	854968
77714652	77714675	1	-	26627737	GBM cells	viability after 5 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	0.5313326927174914	[308]	[245,232]	7	hSpCas9	negative selection	854969
77722057	77722080	1	-	26627737	GBM cells	viability after 5 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	-0.03397192925577763	[62]	[39,25]	0	hSpCas9	negative selection	854970
77723330	77723353	1	-	26627737	GBM cells	viability after 5 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	0.2638685747155992	[402]	[242,275]	4	hSpCas9	negative selection	854971
77725645	77725668	1	-	26627737	GBM cells	viability after 5 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	0.6304250389597835	[105]	[85,89]	8	hSpCas9	negative selection	854972
77736100	77736123	1	+	26627737	GBM cells	viability after 5 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	0.08369683505511105	[482]	[301,246]	1	hSpCas9	negative selection	854973
77711820	77711843	1	+	26627737	GBM cells	viability after 13 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	-0.284823143607087	[234]	[118,92]	-3	hSpCas9	negative selection	937283
77714652	77714675	1	-	26627737	GBM cells	viability after 13 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	0.6010778042652086	[308]	[325,195]	7	hSpCas9	negative selection	937284
77722057	77722080	1	-	26627737	GBM cells	viability after 13 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	0.22276778104739559	[62]	[24,51]	3	hSpCas9	negative selection	937285
77723330	77723353	1	-	26627737	GBM cells	viability after 13 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	0.30192341922738875	[402]	[284,256]	4	hSpCas9	negative selection	937286
77725645	77725668	1	-	26627737	GBM cells	viability after 13 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	0.8488990215961172	[105]	[107,99]	8	hSpCas9	negative selection	937287
77736100	77736123	1	+	26627737	GBM cells	viability after 13 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	0.06127164863894086	[482]	[316,237]	0	hSpCas9	negative selection	937288
77711820	77711843	1	+	26627737	GBM cells	viability after 21 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	-0.26383353390562814	[234]	[121,91]	-2	hSpCas9	negative selection	1019598
77714652	77714675	1	-	26627737	GBM cells	viability after 21 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	0.7961773350984003	[308]	[302,280]	7	hSpCas9	negative selection	1019599
77722057	77722080	1	-	26627737	GBM cells	viability after 21 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	0.52776913575318	[62]	[52,45]	5	hSpCas9	negative selection	1019600
77723330	77723353	1	-	26627737	GBM cells	viability after 21 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	-0.2084332839595059	[402]	[177,199]	-2	hSpCas9	negative selection	1019601
77725645	77725668	1	-	26627737	GBM cells	viability after 21 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	1.9818946506628865	[105]	[227,226]	9	hSpCas9	negative selection	1019602
77736100	77736123	1	+	26627737	GBM cells	viability after 21 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	-0.2585917232019922	[482]	[222,215]	-2	hSpCas9	negative selection	1019603
77711820	77711843	1	+	26627737	RPE1	viability after 9 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	1.9724031565026487	[206]	[221,295]	8	hSpCas9	negative selection	1101913
77714652	77714675	1	-	26627737	RPE1	viability after 9 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	1.030054967042063	[959]	[673,535]	6	hSpCas9	negative selection	1101914
77722057	77722080	1	-	26627737	RPE1	viability after 9 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	-0.8034544193148736	[465]	[97,64]	-5	hSpCas9	negative selection	1101915
77723330	77723353	1	-	26627737	RPE1	viability after 9 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	0.25915957516353305	[1024]	[404,356]	1	hSpCas9	negative selection	1101916
77725645	77725668	1	-	26627737	RPE1	viability after 9 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	0.9354492454441453	[330]	[257,120]	6	hSpCas9	negative selection	1101917
77736100	77736123	1	+	26627737	RPE1	viability after 9 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	0.00508929913597056	[1376]	[367,515]	0	hSpCas9	negative selection	1101918
77711820	77711843	1	+	26627737	RPE1	viability after 12 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	1.53354133228843	[206]	[177,142]	8	hSpCas9	negative selection	1184228
77714652	77714675	1	-	26627737	RPE1	viability after 12 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	0.7689870644826662	[959]	[456,420]	5	hSpCas9	negative selection	1184229
77722057	77722080	1	-	26627737	RPE1	viability after 12 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	-0.7497363813579743	[465]	[89,57]	-5	hSpCas9	negative selection	1184230
77723330	77723353	1	-	26627737	RPE1	viability after 12 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	0.03629949566414725	[1024]	[278,285]	0	hSpCas9	negative selection	1184231
77725645	77725668	1	-	26627737	RPE1	viability after 12 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	0.7978205139034051	[330]	[242,60]	5	hSpCas9	negative selection	1184232
77736100	77736123	1	+	26627737	RPE1	viability after 12 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	0.025797205737639994	[1376]	[363,389]	0	hSpCas9	negative selection	1184233
77711820	77711843	1	+	26627737	RPE1	viability after 15 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	2.5670349560562413	[206]	[290,400]	9	hSpCas9	negative selection	1266543
77714652	77714675	1	-	26627737	RPE1	viability after 15 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	1.25707878860091	[959]	[785,516]	7	hSpCas9	negative selection	1266544
77722057	77722080	1	-	26627737	RPE1	viability after 15 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	0.22879334891965453	[465]	[183,125]	1	hSpCas9	negative selection	1266545
77723330	77723353	1	-	26627737	RPE1	viability after 15 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	0.2360537738450218	[1024]	[369,313]	1	hSpCas9	negative selection	1266546
77725645	77725668	1	-	26627737	RPE1	viability after 15 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	0.4637555186311024	[330]	[177,81]	3	hSpCas9	negative selection	1266547
77736100	77736123	1	+	26627737	RPE1	viability after 15 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	0.34694011399314717	[1376]	[499,490]	2	hSpCas9	negative selection	1266548
77711820	77711843	1	+	26627737	RPE1	viability after 18 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	2.639871219853017	[206]	[163,544]	9	hSpCas9	negative selection	1348858
77714652	77714675	1	-	26627737	RPE1	viability after 18 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	1.116303403191428	[959]	[667,447]	6	hSpCas9	negative selection	1348859
77722057	77722080	1	-	26627737	RPE1	viability after 18 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	-0.34184995608376667	[465]	[32,169]	-2	hSpCas9	negative selection	1348860
77723330	77723353	1	-	26627737	RPE1	viability after 18 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	-0.08881997400363634	[1024]	[262,256]	0	hSpCas9	negative selection	1348861
77725645	77725668	1	-	26627737	RPE1	viability after 18 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	0.8121637217457047	[330]	[195,114]	5	hSpCas9	negative selection	1348862
77736100	77736123	1	+	26627737	RPE1	viability after 18 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	-0.13085017963346468	[1376]	[306,373]	-1	hSpCas9	negative selection	1348863
77711820	77711843	1	+	26627737	HeLa	viability after 8 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	1.0047311678546742	[315]	[115,377,296]	7	hSpCas9	negative selection	1431173
77714652	77714675	1	-	26627737	HeLa	viability after 8 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	0.07666694832826546	[410]	[160,228,170]	0	hSpCas9	negative selection	1431174
77722057	77722080	1	-	26627737	HeLa	viability after 8 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	-1.0121760640051332	[197]	[7,2,104]	-8	hSpCas9	negative selection	1431175
77723330	77723353	1	-	26627737	HeLa	viability after 8 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	-0.6462338147112312	[743]	[231,259,138]	-6	hSpCas9	negative selection	1431176
77725645	77725668	1	-	26627737	HeLa	viability after 8 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	3.8802487977237394	[14]	[132,104,60]	9	hSpCas9	negative selection	1431177
77736100	77736123	1	+	26627737	HeLa	viability after 8 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	0.29796642971754417	[742]	[559,341,330]	3	hSpCas9	negative selection	1431178
77711820	77711843	1	+	26627737	HeLa	viability after 12 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	0.39730697130633164	[315]	[176,210,123]	3	hSpCas9	negative selection	1513488
77714652	77714675	1	-	26627737	HeLa	viability after 12 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	-0.0868124844830282	[410]	[90,157,228]	0	hSpCas9	negative selection	1513489
77722057	77722080	1	-	26627737	HeLa	viability after 12 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	-0.42610851588511967	[197]	[91,9,86]	-4	hSpCas9	negative selection	1513490
77723330	77723353	1	-	26627737	HeLa	viability after 12 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	-0.4517633007446152	[743]	[273,128,282]	-4	hSpCas9	negative selection	1513491
77725645	77725668	1	-	26627737	HeLa	viability after 12 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	4.360395625058648	[14]	[174,111,97]	9	hSpCas9	negative selection	1513492
77736100	77736123	1	+	26627737	HeLa	viability after 12 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	-0.2714287745809798	[742]	[189,313,250]	-2	hSpCas9	negative selection	1513493
77711820	77711843	1	+	26627737	HeLa	viability after 15 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	0.28031572120189185	[315]	[133,238,90]	2	hSpCas9	negative selection	1595803
77714652	77714675	1	-	26627737	HeLa	viability after 15 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	0.12268945175141388	[410]	[142,209,194]	1	hSpCas9	negative selection	1595804
77722057	77722080	1	-	26627737	HeLa	viability after 15 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	0.2768270202801426	[197]	[106,25,164]	2	hSpCas9	negative selection	1595805
77723330	77723353	1	-	26627737	HeLa	viability after 15 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	-0.7631068609591286	[743]	[262,156,108]	-6	hSpCas9	negative selection	1595806
77725645	77725668	1	-	26627737	HeLa	viability after 15 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	4.062748624130942	[14]	[96,157,46]	9	hSpCas9	negative selection	1595807
77736100	77736123	1	+	26627737	HeLa	viability after 15 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	0.16214563960923423	[742]	[277,316,427]	1	hSpCas9	negative selection	1595808
77711820	77711843	1	+	26627737	HeLa	viability after 18 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	0.2943554206763026	[315]	[87,203,90]	2	hSpCas9	negative selection	1678118
77714652	77714675	1	-	26627737	HeLa	viability after 18 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	0.13219863075824487	[410]	[98,172,194]	1	hSpCas9	negative selection	1678119
77722057	77722080	1	-	26627737	HeLa	viability after 18 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	0.252189247505312	[197]	[68,20,164]	2	hSpCas9	negative selection	1678120
77723330	77723353	1	-	26627737	HeLa	viability after 18 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	-0.7826233683745105	[743]	[174,125,108]	-6	hSpCas9	negative selection	1678121
77725645	77725668	1	-	26627737	HeLa	viability after 18 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	4.08047288780594	[14]	[64,133,46]	9	hSpCas9	negative selection	1678122
77736100	77736123	1	+	26627737	HeLa	viability after 18 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	0.1632052328189466	[742]	[184,264,427]	1	hSpCas9	negative selection	1678123
77711820	77711843	1	+	26627737	HCT116	viability after 6 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	2.0324854729198094	[290]	[317,114]	8	hSpCas9	negative selection	1760433
77714652	77714675	1	-	26627737	HCT116	viability after 6 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	-0.9124102687467045	[833]	[117,42]	-5	hSpCas9	negative selection	1760434
77722057	77722080	1	-	26627737	HCT116	viability after 6 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	-0.03157070951524599	[200]	[8,42]	0	hSpCas9	negative selection	1760435
77723330	77723353	1	-	26627737	HCT116	viability after 6 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	0.27128113239112883	[1965]	[450,329]	1	hSpCas9	negative selection	1760436
77725645	77725668	1	-	26627737	HCT116	viability after 6 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	1.083371870188965	[228]	[103,60]	6	hSpCas9	negative selection	1760437
77736100	77736123	1	+	26627737	HCT116	viability after 6 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	-0.03897678058256823	[669]	[175,61]	0	hSpCas9	negative selection	1760438
77711820	77711843	1	+	26627737	HCT116	viability after 8 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	0.377370452361223	[215]	[172,206,84]	4	hSpCas9	negative selection	1842748
77714652	77714675	1	-	26627737	HCT116	viability after 8 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	0.15198297764612634	[209]	[90,161,131]	1	hSpCas9	negative selection	1842749
77722057	77722080	1	-	26627737	HCT116	viability after 8 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	1.6401885661431805	[67]	[142,102,104]	9	hSpCas9	negative selection	1842750
77723330	77723353	1	-	26627737	HCT116	viability after 8 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	0.03076637845015262	[607]	[349,344,331]	0	hSpCas9	negative selection	1842751
77725645	77725668	1	-	26627737	HCT116	viability after 8 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	0.9320305499065935	[118]	[126,175,72]	8	hSpCas9	negative selection	1842752
77736100	77736123	1	+	26627737	HCT116	viability after 8 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	0.2194564772941065	[387]	[214,185,343]	2	hSpCas9	negative selection	1842753
77711820	77711843	1	+	26627737	HCT116	viability after 9 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	1.8372310323860463	[290]	[404,176]	9	hSpCas9	negative selection	1925063
77714652	77714675	1	-	26627737	HCT116	viability after 9 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	-0.9623800016084312	[833]	[163,74]	-6	hSpCas9	negative selection	1925064
77722057	77722080	1	-	26627737	HCT116	viability after 9 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	1.5610876369567517	[200]	[6,277]	8	hSpCas9	negative selection	1925065
77723330	77723353	1	-	26627737	HCT116	viability after 9 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	-0.8735530566161304	[1965]	[333,248]	-6	hSpCas9	negative selection	1925066
77725645	77725668	1	-	26627737	HCT116	viability after 9 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	1.3802212739465718	[228]	[209,118]	8	hSpCas9	negative selection	1925067
77736100	77736123	1	+	26627737	HCT116	viability after 9 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	0.6095868329059037	[669]	[339,219]	4	hSpCas9	negative selection	1925068
77711820	77711843	1	+	26627737	HCT116	viability after 12 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	0.46921261839280637	[215]	[181,146,139]	4	hSpCas9	negative selection	2007378
77714652	77714675	1	-	26627737	HCT116	viability after 12 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	0.5743053116058137	[209]	[90,229,179]	5	hSpCas9	negative selection	2007379
77722057	77722080	1	-	26627737	HCT116	viability after 12 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	1.5954290472652204	[67]	[119,152,50]	9	hSpCas9	negative selection	2007380
77723330	77723353	1	-	26627737	HCT116	viability after 12 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	0.026418471979665625	[607]	[281,362,335]	0	hSpCas9	negative selection	2007381
77725645	77725668	1	-	26627737	HCT116	viability after 12 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	0.5280920593353637	[118]	[122,62,80]	5	hSpCas9	negative selection	2007382
77736100	77736123	1	+	26627737	HCT116	viability after 12 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	0.13815274265277616	[387]	[154,253,270]	1	hSpCas9	negative selection	2007383
77711820	77711843	1	+	26627737	HCT116	viability after 15 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	0.07500611828842596	[215]	[92,128,164]	0	hSpCas9	negative selection	2089693
77714652	77714675	1	-	26627737	HCT116	viability after 15 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	0.5478829812846819	[209]	[132,241,148]	5	hSpCas9	negative selection	2089694
77722057	77722080	1	-	26627737	HCT116	viability after 15 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	1.6306421228814545	[67]	[130,111,120]	9	hSpCas9	negative selection	2089695
77723330	77723353	1	-	26627737	HCT116	viability after 15 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	-0.4215464935036123	[607]	[297,257,230]	-4	hSpCas9	negative selection	2089696
77725645	77725668	1	-	26627737	HCT116	viability after 15 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	0.6236534411870542	[118]	[134,119,64]	5	hSpCas9	negative selection	2089697
77736100	77736123	1	+	26627737	HCT116	viability after 15 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	0.6463408267233561	[387]	[424,233,395]	6	hSpCas9	negative selection	2089698
77711820	77711843	1	+	26627737	HCT116	viability after 18 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	1.023190772099604	[215]	[143,271,216]	7	hSpCas9	negative selection	2172008
77714652	77714675	1	-	26627737	HCT116	viability after 18 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	-0.01986186663267464	[209]	[61,144,89]	0	hSpCas9	negative selection	2172009
77722057	77722080	1	-	26627737	HCT116	viability after 18 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	1.843878400365937	[67]	[156,127,65]	9	hSpCas9	negative selection	2172010
77723330	77723353	1	-	26627737	HCT116	viability after 18 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	0.17579684614535984	[607]	[400,235,366]	1	hSpCas9	negative selection	2172011
77725645	77725668	1	-	26627737	HCT116	viability after 18 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	-0.23785681836095618	[118]	[54,74,12]	-2	hSpCas9	negative selection	2172012
77736100	77736123	1	+	26627737	HCT116	viability after 18 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	-0.17625499762501412	[387]	[162,175,157]	-2	hSpCas9	negative selection	2172013
77739287	77739310	1	+	24336569	HL60	viability	TGGTGAGGTTGTCTTACATGAGG	USP33	ENSG00000077254	0.08260317168961984	[1041]	[2334]	0	hSpCas9	negative selection	2305431
77739296	77739319	1	+	24336569	HL60	viability	TGTCTTACATGAGGCAATGAAGG	USP33	ENSG00000077254	0.12226072899610818	[1288]	[2968]	1	hSpCas9	negative selection	2305432
77739364	77739387	1	+	24336569	HL60	viability	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	-0.18378180211771106	[722]	[1346]	-1	hSpCas9	negative selection	2305433
77739369	77739392	1	+	24336569	HL60	viability	ACCATACTCGAAGAGTGGTAAGG	USP33	ENSG00000077254	-0.41609778653502183	[1168]	[1853]	-4	hSpCas9	negative selection	2305434
77740868	77740891	1	+	24336569	HL60	viability	TATACATACCTGAGAATGTATGG	USP33	ENSG00000077254	-0.022085553549964665	[118]	[247]	0	hSpCas9	negative selection	2305435
77741375	77741398	1	-	24336569	HL60	viability	AAATCTTTGGGCATGTCTGGAGG	USP33	ENSG00000077254	-0.7798729826667669	[842]	[1038]	-6	hSpCas9	negative selection	2305436
77741384	77741407	1	+	24336569	HL60	viability	ATGCCCAAAGATTTGGTCCTTGG	USP33	ENSG00000077254	0.9635456342886696	[496]	[2050]	7	hSpCas9	negative selection	2305437
77741401	77741424	1	-	24336569	HL60	viability	TGTCAGGATTGTAAAGTCCAAGG	USP33	ENSG00000077254	-0.08260412047556509	[632]	[1264]	0	hSpCas9	negative selection	2305438
77741651	77741674	1	+	24336569	HL60	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.2941934246146247	[433]	[748]	-3	hSpCas9	negative selection	2305439
77741664	77741687	1	-	24336569	HL60	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.13832609889033032	[871]	[2030]	1	hSpCas9	negative selection	2305440
77739287	77739310	1	+	24336569	KBM7	viability	TGGTGAGGTTGTCTTACATGAGG	USP33	ENSG00000077254	0.23305539770265793	[913]	[2929]	2	hSpCas9	negative selection	2372608
77739296	77739319	1	+	24336569	KBM7	viability	TGTCTTACATGAGGCAATGAAGG	USP33	ENSG00000077254	-0.2572152041161573	[988]	[2256]	-2	hSpCas9	negative selection	2372609
77739364	77739387	1	+	24336569	KBM7	viability	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	0.34848991796220646	[549]	[1909]	3	hSpCas9	negative selection	2372610
77739369	77739392	1	+	24336569	KBM7	viability	ACCATACTCGAAGAGTGGTAAGG	USP33	ENSG00000077254	0.6430648919461366	[905]	[3858]	6	hSpCas9	negative selection	2372611
77740868	77740891	1	+	24336569	KBM7	viability	TATACATACCTGAGAATGTATGG	USP33	ENSG00000077254	-0.04817234898380285	[115]	[305]	0	hSpCas9	negative selection	2372612
77741375	77741398	1	-	24336569	KBM7	viability	AAATCTTTGGGCATGTCTGGAGG	USP33	ENSG00000077254	-0.20507507953658397	[518]	[1227]	-2	hSpCas9	negative selection	2372613
77741384	77741407	1	+	24336569	KBM7	viability	ATGCCCAAAGATTTGGTCCTTGG	USP33	ENSG00000077254	0.5028152574473223	[428]	[1657]	4	hSpCas9	negative selection	2372614
77741401	77741424	1	-	24336569	KBM7	viability	TGTCAGGATTGTAAAGTCCAAGG	USP33	ENSG00000077254	0.02365022765494096	[619]	[1718]	0	hSpCas9	negative selection	2372615
77741651	77741674	1	+	24336569	KBM7	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.042841450640893244	[368]	[976]	0	hSpCas9	negative selection	2372616
77741664	77741687	1	-	24336569	KBM7	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.4585814749151057	[658]	[2469]	4	hSpCas9	negative selection	2372617
77711544	77711567	1	+	25494202	A375	resistance to PLX-4720 (puromycin)	CACACACACACACACACAAAGGG	USP33	ENSG00000077254	0.9199176005020689	[142,31]	[20,50]	4	dCas9-VP64	positive selection	2387546
77750387	77750410	1	+	25494202	A375	resistance to PLX-4720 (puromycin)	CTTTGGGAGGCCAAGGCGGGAAG	USP33	ENSG00000077254	0.09588317305989913	[114,12]	[10,18]	0	dCas9-VP64	positive selection	2411085
77701711	77701734	1	-	25494202	A375	resistance to PLX-4720 (puromycin)	CGTGCCATTGCACTCCAGCCTGG	USP33	ENSG00000077254	-0.5971814264096912	[233,130]	[36,14]	-3	dCas9-VP64	positive selection	2447063
77711544	77711567	1	+	25494202	A375	resistance to PLX-4720 (zeocin)	CACACACACACACACACAAAGGG	USP33	ENSG00000077254	-0.3445413987388147	[115,152]	[39,27]	-3	dCas9-VP64	positive selection	2482801
77750387	77750410	1	+	25494202	A375	resistance to PLX-4720 (zeocin)	CTTTGGGAGGCCAAGGCGGGAAG	USP33	ENSG00000077254	3.077269363618506	[19,18]	[13,93]	9	dCas9-VP64	positive selection	2506340
77701711	77701734	1	-	25494202	A375	resistance to PLX-4720 (zeocin)	CGTGCCATTGCACTCCAGCCTGG	USP33	ENSG00000077254	0.14726127288975888	[140,101]	[59,28]	1	dCas9-VP64	positive selection	2542318
77739365	77739388	1	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	-0.216914112981337	[3,3]	[3,1]	-3	hSpCas9	positive selection	3031349
77729872	77729895	1	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CTGTAAATCCAACATTTCGGGGG	USP33	ENSG00000077254	0.16714617717204208	[3,3]	[4,2]	3	hSpCas9	positive selection	3031350
77728580	77728603	1	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGAAGAAGACAAGAGCCAGTCGG	USP33	ENSG00000077254	0.31128855991664606	[4,4]	[5,4]	6	hSpCas9	positive selection	3031351
77736083	77736106	1	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	0.0992471513070215	[4,4]	[2,4]	2	hSpCas9	positive selection	3031352
77739365	77739388	1	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	0.7267141718381123	[3,3]	[3,4]	9	hSpCas9	positive selection	3099207
77729872	77729895	1	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CTGTAAATCCAACATTTCGGGGG	USP33	ENSG00000077254	-0.32209748068127386	[3,3]	[2,0]	-5	hSpCas9	positive selection	3099208
77728580	77728603	1	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGAAGAAGACAAGAGCCAGTCGG	USP33	ENSG00000077254	-0.14267846304765605	[4,4]	[4,1]	-2	hSpCas9	positive selection	3099209
77736083	77736106	1	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.7419721342681843	[4,4]	[1,0]	-8	hSpCas9	positive selection	3099210
77741684	77741707		+	24336571	A375	resistance to PLX after 7 days	CGAAAAGCTGACATTTTGTTAGG	USP33	ENSG00000077254	0.12909781380947605	[39,40]	[41,45]	4	hSpCas9	positive selection	3154610
77741417	77741440		-	24336571	A375	resistance to PLX after 7 days	CTTTTTATAGGGTACTTGTCAGG	USP33	ENSG00000077254	-0.04498195711924757	[38,40]	[37,37]	-1	hSpCas9	positive selection	3154611
77741651	77741674		+	24336571	A375	resistance to PLX after 7 days	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	0.35920516768133104	[26,23]	[32,31]	8	hSpCas9	positive selection	3154612
77741377	77741400		+	24336571	A375	resistance to PLX after 7 days	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	-0.06496378277664006	[76,74]	[70,72]	-2	hSpCas9	positive selection	3154613
77741664	77741687		-	24336571	A375	resistance to PLX after 7 days	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	-0.013163651012237487	[83,80]	[79,81]	0	hSpCas9	positive selection	3154615
77741684	77741707		+	24336571	A375	resistance to PLX after 14 days	CGAAAAGCTGACATTTTGTTAGG	USP33	ENSG00000077254	0.9284433583453824	[39,50]	[36,42]	7	hSpCas9	positive selection	3212403
77741417	77741440		-	24336571	A375	resistance to PLX after 14 days	CTTTTTATAGGGTACTTGTCAGG	USP33	ENSG00000077254	-0.2823895094694948	[33,34]	[11,13]	-3	hSpCas9	positive selection	3212404
77741651	77741674		+	24336571	A375	resistance to PLX after 14 days	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	0.33095518491821085	[32,22]	[15,16]	3	hSpCas9	positive selection	3212405
77741377	77741400		+	24336571	A375	resistance to PLX after 14 days	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	-0.3694897149097476	[58,69]	[23,21]	-4	hSpCas9	positive selection	3212406
77741664	77741687		-	24336571	A375	resistance to PLX after 14 days	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	-0.27542419564126686	[98,96]	[39,34]	-3	hSpCas9	positive selection	3212408
77741684	77741707		+	24336571	A375	viability after 7 days	CGAAAAGCTGACATTTTGTTAGG	USP33	ENSG00000077254	0.42816780799999465	[30]	[39,40]	6	hSpCas9	negative selection	3270196
77741417	77741440		-	24336571	A375	viability after 7 days	CTTTTTATAGGGTACTTGTCAGG	USP33	ENSG00000077254	0.34587818838725126	[32]	[38,40]	5	hSpCas9	negative selection	3270197
77741651	77741674		+	24336571	A375	viability after 7 days	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.34407445593463937	[33]	[26,23]	-5	hSpCas9	negative selection	3270198
77741377	77741400		+	24336571	A375	viability after 7 days	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.46536509616127963	[57]	[76,74]	7	hSpCas9	negative selection	3270199
77741664	77741687		-	24336571	A375	viability after 7 days	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.5273839918801819	[59]	[83,80]	7	hSpCas9	negative selection	3270201
77741684	77741707		+	24336571	A375	viability after 14 days	CGAAAAGCTGACATTTTGTTAGG	USP33	ENSG00000077254	0.6165028743758676	[30]	[39,50]	7	hSpCas9	negative selection	3327989
77741417	77741440		-	24336571	A375	viability after 14 days	CTTTTTATAGGGTACTTGTCAGG	USP33	ENSG00000077254	0.1706059366635062	[32]	[33,34]	2	hSpCas9	negative selection	3327990
77741651	77741674		+	24336571	A375	viability after 14 days	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.17200458839009491	[33]	[32,22]	-2	hSpCas9	negative selection	3327991
77741377	77741400		+	24336571	A375	viability after 14 days	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.2491602614108559	[57]	[58,69]	3	hSpCas9	negative selection	3327992
77741664	77741687		-	24336571	A375	viability after 14 days	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.7968325163724903	[59]	[98,96]	8	hSpCas9	negative selection	3327994
77741651	77741674	1	+	27383988	293T	resistance to West Nile virus (flavivirus)	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.1177132199010895	[165,165]	[0,0]	0	hSpCas9	positive selection	3400597
77741664	77741687	1	-	27383988	293T	resistance to West Nile virus (flavivirus)	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.6723637107246789	[95,95]	[0,0]	3	hSpCas9	positive selection	3400598
77741388	77741411	1	-	27383988	293T	resistance to West Nile virus (flavivirus)	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	-0.7705797851240493	[260,260]	[0,0]	-5	hSpCas9	positive selection	3400599
77739364	77739387	1	+	26780180	HT29	viability (Avana library 4 designs)	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	0.962418982401146	[]	[]	4	hSpCas9	negative selection	3470545
77729872	77729895	1	-	26780180	HT29	viability (Avana library 4 designs)	CTGTAAATCCAACATTTCGGGGG	USP33	ENSG00000077254	2.63636482280355	[]	[]	8	hSpCas9	negative selection	3470546
77728580	77728603	1	-	26780180	HT29	viability (Avana library 4 designs)	GGAAGAAGACAAGAGCCAGTCGG	USP33	ENSG00000077254	1.43958816661746	[]	[]	5	hSpCas9	negative selection	3470547
77736083	77736106	1	-	26780180	HT29	viability (Avana library 4 designs)	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	2.07127772453061	[]	[]	7	hSpCas9	negative selection	3470548
77728580	77728603	1	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGAAGAAGACAAGAGCCAGTCGG	USP33	ENSG00000077254	0.249029976964709	[]	[]	0	hSpCas9	negative selection	3576733
77736083	77736106	1	-	26780180	A375	viability (Avana lentiCRISPRv2)	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-15.7185602893586	[]	[]	-9	hSpCas9	negative selection	3576734
77739364	77739387	1	+	26780180	A375	viability (Avana lentiCRISPRv2)	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	1.03408479718661	[]	[]	1	hSpCas9	negative selection	3576735
77729872	77729895	1	-	26780180	A375	viability (Avana lentiCRISPRv2)	CTGTAAATCCAACATTTCGGGGG	USP33	ENSG00000077254	-5.07344083661853	[]	[]	-5	hSpCas9	negative selection	3576736
77728519	77728542	1	-	26780180	A375	viability (Avana lentiCRISPRv2)	GATAGAGCAGAAAATGAAAATGG	USP33	ENSG00000077254	-6.80470862304739	[]	[]	-6	hSpCas9	negative selection	3576737
77736100	77736123	1	+	26780180	A375	viability (Avana lentiCRISPRv2)	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	-4.10350862905174	[]	[]	-5	hSpCas9	negative selection	3576738
77728580	77728603	1	-	26780180	A375	viability (Avana lentiGuide)	GGAAGAAGACAAGAGCCAGTCGG	USP33	ENSG00000077254	-1.37759898629169	[]	[]	-2	hSpCas9	negative selection	3685392
77736083	77736106	1	-	26780180	A375	viability (Avana lentiGuide)	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	3.37073440698941	[]	[]	3	hSpCas9	negative selection	3685393
77739364	77739387	1	+	26780180	A375	viability (Avana lentiGuide)	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	3.2023477374465	[]	[]	3	hSpCas9	negative selection	3685394
77729872	77729895	1	-	26780180	A375	viability (Avana lentiGuide)	CTGTAAATCCAACATTTCGGGGG	USP33	ENSG00000077254	8.80211300720662	[]	[]	6	hSpCas9	negative selection	3685395
77728519	77728542	1	-	26780180	A375	viability (Avana lentiGuide)	GATAGAGCAGAAAATGAAAATGG	USP33	ENSG00000077254	-3.38105678739876	[]	[]	-6	hSpCas9	negative selection	3685396
77736100	77736123	1	+	26780180	A375	viability (Avana lentiGuide)	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	4.09006572101064	[]	[]	4	hSpCas9	negative selection	3685397
77728580	77728603	1	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGAAGAAGACAAGAGCCAGTCGG	USP33	ENSG00000077254	-0.24564818064834576	[5]	[5,3]	-4	hSpCas9	positive selection	3793999
77736083	77736106	1	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-1.2714748359793606	[8]	[4,1]	-9	hSpCas9	positive selection	3794000
77739364	77739387	1	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	-0.056218070041807906	[5]	[5,4]	-1	hSpCas9	positive selection	3794001
77729872	77729895	1	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CTGTAAATCCAACATTTCGGGGG	USP33	ENSG00000077254	-0.6829868864150765	[4]	[2,2]	-7	hSpCas9	positive selection	3794002
77728519	77728542	1	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GATAGAGCAGAAAATGAAAATGG	USP33	ENSG00000077254	-0.5216272691171211	[6]	[4,3]	-6	hSpCas9	positive selection	3794003
77736100	77736123	1	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	-0.40084015961578506	[4]	[4,2]	-5	hSpCas9	positive selection	3794004
77728580	77728603	1	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGAAGAAGACAAGAGCCAGTCGG	USP33	ENSG00000077254	0.04085305760364988	[6]	[5,5]	0	hSpCas9	positive selection	3902606
77736083	77736106	1	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.18303842799492803	[6]	[4,4]	-3	hSpCas9	positive selection	3902607
77739364	77739387	1	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	-0.25112784159438745	[5]	[4,2]	-3	hSpCas9	positive selection	3902608
77729872	77729895	1	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CTGTAAATCCAACATTTCGGGGG	USP33	ENSG00000077254	-0.4874716317523181	[5]	[2,3]	-6	hSpCas9	positive selection	3902609
77728519	77728542	1	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GATAGAGCAGAAAATGAAAATGG	USP33	ENSG00000077254	0.23111025659502238	[5]	[5,5]	6	hSpCas9	positive selection	3902610
77736100	77736123	1	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	0.07908461601149518	[5]	[6,3]	1	hSpCas9	positive selection	3902611
77741388	77741411	1	-	26780180	A375	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.700099546614963	[]	[]	2	hSpCas9	negative selection	4010937
77736090	77736113	1	+	26780180	A375	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	1.45835959447689	[]	[]	8	hSpCas9	negative selection	4010938
77741651	77741674	1	+	26780180	A375	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	1.73562232238434	[]	[]	9	hSpCas9	negative selection	4010939
77741377	77741400	1	+	26780180	A375	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.901225037724825	[]	[]	4	hSpCas9	negative selection	4010940
77741664	77741687	1	-	26780180	A375	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.82877985146999	[]	[]	3	hSpCas9	negative selection	4010941
77736083	77736106	1	-	26780180	A375	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	1.35157293298838	[]	[]	7	hSpCas9	negative selection	4010942
77741388	77741411	1	-	26780180	HT29	viability (GeCKOv2 library)	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	1.08215127550827	[]	[]	5	hSpCas9	negative selection	4118903
77736090	77736113	1	+	26780180	HT29	viability (GeCKOv2 library)	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	1.5307967135444	[]	[]	7	hSpCas9	negative selection	4118904
77741651	77741674	1	+	26780180	HT29	viability (GeCKOv2 library)	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	1.22060408519341	[]	[]	6	hSpCas9	negative selection	4118905
77741377	77741400	1	+	26780180	HT29	viability (GeCKOv2 library)	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.260655030695597	[]	[]	0	hSpCas9	negative selection	4118906
77741664	77741687	1	-	26780180	HT29	viability (GeCKOv2 library)	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	1.2725147415825	[]	[]	6	hSpCas9	negative selection	4118907
77736083	77736106	1	-	26780180	HT29	viability (GeCKOv2 library)	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	0.956680564788373	[]	[]	4	hSpCas9	negative selection	4118908
77741684	77741707	1	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CGAAAAGCTGACATTTTGTTAGG	USP33	ENSG00000077254	0.42664559870029023	[5]	[4,5]	8	hSpCas9	positive selection	4181333
77741417	77741440	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTTTTTATAGGGTACTTGTCAGG	USP33	ENSG00000077254	0.1810749892827339	[4]	[3,3]	4	hSpCas9	positive selection	4181334
77741651	77741674	1	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	0.2265233304176988	[4]	[3,3]	6	hSpCas9	positive selection	4181335
77741377	77741400	1	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.13165369006911265	[5]	[4,4]	3	hSpCas9	positive selection	4181336
77741664	77741687	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.21919598604717716	[5]	[4,5]	5	hSpCas9	positive selection	4181339
77741684	77741707	1	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CGAAAAGCTGACATTTTGTTAGG	USP33	ENSG00000077254	1.0388448858560566	[5]	[5,3,4,4]	7	hSpCas9	positive selection	4245355
77741417	77741440	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTTTTTATAGGGTACTTGTCAGG	USP33	ENSG00000077254	0.9082237221127701	[4]	[4,4,2,3]	6	hSpCas9	positive selection	4245356
77741651	77741674	1	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	1.0525450246104806	[5]	[4,6,5,3]	7	hSpCas9	positive selection	4245357
77741377	77741400	1	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.7759207218775255	[5]	[5,2,3,3]	5	hSpCas9	positive selection	4245358
77741664	77741687	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.8558002625978272	[6]	[5,5,4,4]	5	hSpCas9	positive selection	4245361
77741377	77741400	1	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.2840971953772732	[3]	[2,3]	6	hSpCas9	positive selection	4306956
77736090	77736113	1	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	0.6378468905620865	[2]	[3,3]	9	hSpCas9	positive selection	4306957
77736083	77736106	1	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.4109421199937835	[2]	[1,0]	-7	hSpCas9	positive selection	4306958
77741651	77741674	1	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.3671586609016652	[3]	[2,1]	-7	hSpCas9	positive selection	4371203
77741664	77741687	1	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.5741909084696241	[2]	[2,3]	9	hSpCas9	positive selection	4371204
77741388	77741411	1	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.21561393913268254	[3]	[3,2]	4	hSpCas9	positive selection	4371205
77728331	77728353	1	-	27760321	OCIAML3	viability	ACAGTCGACTTAAACAACCAGG	USP33	ENSG00000077254	0.8026316621573424	[181,118]	[132,292]	8	hSpCas9	negative selection	4452724
77728610	77728632	1	-	27760321	OCIAML3	viability	CCGCAAACCATAACCACTGAGG	USP33	ENSG00000077254	0.6098064912027539	[274,200]	[207,376]	7	hSpCas9	negative selection	4452725
77728677	77728699	1	+	27760321	OCIAML3	viability	CAAATCCATTAAACATCGAAGG	USP33	ENSG00000077254	0.1518214461968801	[206,193]	[182,162]	1	hSpCas9	negative selection	4452726
77729859	77729881	1	-	27760321	OCIAML3	viability	TTTCGGGGGTATTCTCAGCAGG	USP33	ENSG00000077254	-0.8011318328322465	[365,284]	[115,182]	-6	hSpCas9	negative selection	4452727
77739370	77739392	1	-	27760321	OCIAML3	viability	CCTTACCACTCTTCGAGTATGG	USP33	ENSG00000077254	0.12801921215939563	[377,346]	[284,341]	1	hSpCas9	negative selection	4452728
77728331	77728353	1	-	27760321	OCIAML2	viability	ACAGTCGACTTAAACAACCAGG	USP33	ENSG00000077254	0.2877738800234617	[181,118]	[168,116]	4	hSpCas9	negative selection	4536187
77728610	77728632	1	-	27760321	OCIAML2	viability	CCGCAAACCATAACCACTGAGG	USP33	ENSG00000077254	-0.2583566359118331	[274,200]	[136,188]	-3	hSpCas9	negative selection	4536188
77728677	77728699	1	+	27760321	OCIAML2	viability	CAAATCCATTAAACATCGAAGG	USP33	ENSG00000077254	0.8205263866882382	[206,193]	[236,351]	9	hSpCas9	negative selection	4536189
77729859	77729881	1	-	27760321	OCIAML2	viability	TTTCGGGGGTATTCTCAGCAGG	USP33	ENSG00000077254	-0.14641219559177476	[365,284]	[177,312]	-2	hSpCas9	negative selection	4536190
77739370	77739392	1	-	27760321	OCIAML2	viability	CCTTACCACTCTTCGAGTATGG	USP33	ENSG00000077254	-0.024298093864045966	[377,346]	[308,260]	0	hSpCas9	negative selection	4536191
77728331	77728353	1	-	27760321	MV411	viability	ACAGTCGACTTAAACAACCAGG	USP33	ENSG00000077254	-3.475541183706266	[181,118]	[13,0]	-9	hSpCas9	negative selection	4619650
77728610	77728632	1	-	27760321	MV411	viability	CCGCAAACCATAACCACTGAGG	USP33	ENSG00000077254	-1.8422299829123365	[274,200]	[26,67]	-8	hSpCas9	negative selection	4619651
77728677	77728699	1	+	27760321	MV411	viability	CAAATCCATTAAACATCGAAGG	USP33	ENSG00000077254	-0.7053764050480202	[206,193]	[73,91]	-5	hSpCas9	negative selection	4619652
77729859	77729881	1	-	27760321	MV411	viability	TTTCGGGGGTATTCTCAGCAGG	USP33	ENSG00000077254	1.4780838099171236	[365,284]	[393,894]	9	hSpCas9	negative selection	4619653
77739370	77739392	1	-	27760321	MV411	viability	CCTTACCACTCTTCGAGTATGG	USP33	ENSG00000077254	-0.23876140718495587	[377,346]	[300,54]	-2	hSpCas9	negative selection	4619654
77728331	77728353	1	-	27760321	HL60	viability	ACAGTCGACTTAAACAACCAGG	USP33	ENSG00000077254	-0.3083907908849628	[181,118]	[77,118]	-3	hSpCas9	negative selection	4703113
77728610	77728632	1	-	27760321	HL60	viability	CCGCAAACCATAACCACTGAGG	USP33	ENSG00000077254	-0.5435971708494186	[274,200]	[135,127]	-5	hSpCas9	negative selection	4703114
77728677	77728699	1	+	27760321	HL60	viability	CAAATCCATTAAACATCGAAGG	USP33	ENSG00000077254	-0.39434199849295815	[206,193]	[130,117]	-4	hSpCas9	negative selection	4703115
77729859	77729881	1	-	27760321	HL60	viability	TTTCGGGGGTATTCTCAGCAGG	USP33	ENSG00000077254	-0.3229448473470041	[365,284]	[180,242]	-4	hSpCas9	negative selection	4703116
77739370	77739392	1	-	27760321	HL60	viability	CCTTACCACTCTTCGAGTATGG	USP33	ENSG00000077254	0.1414304690910474	[377,346]	[327,324]	1	hSpCas9	negative selection	4703117
77728331	77728353	1	-	27760321	HT1080	viability	ACAGTCGACTTAAACAACCAGG	USP33	ENSG00000077254	0.7507976074128533	[118,92]	[103,34]	4	hSpCas9	negative selection	4786576
77728610	77728632	1	-	27760321	HT1080	viability	CCGCAAACCATAACCACTGAGG	USP33	ENSG00000077254	0.7560464888777421	[200,156]	[97,144]	4	hSpCas9	negative selection	4786577
77728677	77728699	1	+	27760321	HT1080	viability	CAAATCCATTAAACATCGAAGG	USP33	ENSG00000077254	-1.7445884621912469	[193,151]	[0,41]	-6	hSpCas9	negative selection	4786578
77729859	77729881	1	-	27760321	HT1080	viability	TTTCGGGGGTATTCTCAGCAGG	USP33	ENSG00000077254	-1.4516419756500107	[284,222]	[36,36]	-5	hSpCas9	negative selection	4786579
77739370	77739392	1	-	27760321	HT1080	viability	CCTTACCACTCTTCGAGTATGG	USP33	ENSG00000077254	-1.7536739006076727	[346,270]	[4,70]	-6	hSpCas9	negative selection	4786580
77728331	77728353	1	-	27760321	HT29	viability after 7 days	ACAGTCGACTTAAACAACCAGG	USP33	ENSG00000077254	-0.17838452804282223	[118,92]	[187,68,113]	-3	hSpCas9	negative selection	4870039
77728610	77728632	1	-	27760321	HT29	viability after 7 days	CCGCAAACCATAACCACTGAGG	USP33	ENSG00000077254	0.3294619084184751	[200,156]	[282,252,328]	5	hSpCas9	negative selection	4870040
77728677	77728699	1	+	27760321	HT29	viability after 7 days	CAAATCCATTAAACATCGAAGG	USP33	ENSG00000077254	0.47833762425882154	[193,151]	[267,236,414]	7	hSpCas9	negative selection	4870041
77729859	77729881	1	-	27760321	HT29	viability after 7 days	TTTCGGGGGTATTCTCAGCAGG	USP33	ENSG00000077254	-0.7097679095329434	[284,222]	[203,181,212]	-7	hSpCas9	negative selection	4870042
77739370	77739392	1	-	27760321	HT29	viability after 7 days	CCTTACCACTCTTCGAGTATGG	USP33	ENSG00000077254	0.27173663507546664	[346,270]	[759,485,239]	4	hSpCas9	negative selection	4870043
77728331	77728353	1	-	27760321	HT29	viability after 25 days	ACAGTCGACTTAAACAACCAGG	USP33	ENSG00000077254	0.6040578769105325	[118,92]	[201,78,279]	6	hSpCas9	negative selection	4953502
77728610	77728632	1	-	27760321	HT29	viability after 25 days	CCGCAAACCATAACCACTGAGG	USP33	ENSG00000077254	0.6751804471008364	[200,156]	[287,495,182]	7	hSpCas9	negative selection	4953503
77728677	77728699	1	+	27760321	HT29	viability after 25 days	CAAATCCATTAAACATCGAAGG	USP33	ENSG00000077254	-0.48737686126867397	[193,151]	[101,211,107]	-4	hSpCas9	negative selection	4953504
77729859	77729881	1	-	27760321	HT29	viability after 25 days	TTTCGGGGGTATTCTCAGCAGG	USP33	ENSG00000077254	-0.5794585516877804	[284,222]	[210,128,246]	-5	hSpCas9	negative selection	4953505
77739370	77739392	1	-	27760321	HT29	viability after 25 days	CCTTACCACTCTTCGAGTATGG	USP33	ENSG00000077254	0.26044702376164475	[346,270]	[419,447,397]	2	hSpCas9	negative selection	4953506
77728331	77728353	1	-	27760321	HT29	viability after 22 days	ACAGTCGACTTAAACAACCAGG	USP33	ENSG00000077254	-0.20293963493339562	[118,92]	[97,76,144]	-2	hSpCas9	negative selection	5036965
77728610	77728632	1	-	27760321	HT29	viability after 22 days	CCGCAAACCATAACCACTGAGG	USP33	ENSG00000077254	0.1961773155424219	[200,156]	[243,340,124]	2	hSpCas9	negative selection	5036966
77728677	77728699	1	+	27760321	HT29	viability after 22 days	CAAATCCATTAAACATCGAAGG	USP33	ENSG00000077254	0.3910809228103477	[193,151]	[213,342,230]	4	hSpCas9	negative selection	5036967
77729859	77729881	1	-	27760321	HT29	viability after 22 days	TTTCGGGGGTATTCTCAGCAGG	USP33	ENSG00000077254	-1.2917666089696898	[284,222]	[81,146,131]	-7	hSpCas9	negative selection	5036968
77739370	77739392	1	-	27760321	HT29	viability after 22 days	CCTTACCACTCTTCGAGTATGG	USP33	ENSG00000077254	0.5390960037381711	[346,270]	[621,668,260]	6	hSpCas9	negative selection	5036969
77728331	77728353	1	-	27760321	HT29	viability after 19 days	ACAGTCGACTTAAACAACCAGG	USP33	ENSG00000077254	-0.42123390368222835	[118,92]	[96,131,44]	-4	hSpCas9	negative selection	5120428
77728610	77728632	1	-	27760321	HT29	viability after 19 days	CCGCAAACCATAACCACTGAGG	USP33	ENSG00000077254	-0.03052137554846568	[200,156]	[376,184,62]	0	hSpCas9	negative selection	5120429
77728677	77728699	1	+	27760321	HT29	viability after 19 days	CAAATCCATTAAACATCGAAGG	USP33	ENSG00000077254	0.4953988005776371	[193,151]	[279,173,378]	5	hSpCas9	negative selection	5120430
77729859	77729881	1	-	27760321	HT29	viability after 19 days	TTTCGGGGGTATTCTCAGCAGG	USP33	ENSG00000077254	-0.36034451647141075	[284,222]	[136,239,289]	-3	hSpCas9	negative selection	5120431
77739370	77739392	1	-	27760321	HT29	viability after 19 days	CCTTACCACTCTTCGAGTATGG	USP33	ENSG00000077254	0.11887993081071511	[346,270]	[390,462,300]	1	hSpCas9	negative selection	5120432
77728331	77728353	1	-	27760321	HT29	viability after 16 days	ACAGTCGACTTAAACAACCAGG	USP33	ENSG00000077254	0.19711351061910487	[118,92]	[176,49,186]	2	hSpCas9	negative selection	5203891
77728610	77728632	1	-	27760321	HT29	viability after 16 days	CCGCAAACCATAACCACTGAGG	USP33	ENSG00000077254	0.12173913059829522	[200,156]	[173,391,78]	1	hSpCas9	negative selection	5203892
77728677	77728699	1	+	27760321	HT29	viability after 16 days	CAAATCCATTAAACATCGAAGG	USP33	ENSG00000077254	-0.5062476726906755	[193,151]	[112,200,90]	-5	hSpCas9	negative selection	5203893
77729859	77729881	1	-	27760321	HT29	viability after 16 days	TTTCGGGGGTATTCTCAGCAGG	USP33	ENSG00000077254	-0.48659719548980973	[284,222]	[121,159,319]	-5	hSpCas9	negative selection	5203894
77739370	77739392	1	-	27760321	HT29	viability after 16 days	CCTTACCACTCTTCGAGTATGG	USP33	ENSG00000077254	-0.22237551622848073	[346,270]	[254,451,173]	-3	hSpCas9	negative selection	5203895
77728331	77728353	1	-	27760321	HT29	viability after 13 days	ACAGTCGACTTAAACAACCAGG	USP33	ENSG00000077254	0.17370016087421658	[118,92]	[82,104,222]	2	hSpCas9	negative selection	5287354
77728610	77728632	1	-	27760321	HT29	viability after 13 days	CCGCAAACCATAACCACTGAGG	USP33	ENSG00000077254	0.4574328569061371	[200,156]	[221,287,341]	6	hSpCas9	negative selection	5287355
77728677	77728699	1	+	27760321	HT29	viability after 13 days	CAAATCCATTAAACATCGAAGG	USP33	ENSG00000077254	0.24553465627771598	[193,151]	[158,246,303]	3	hSpCas9	negative selection	5287356
77729859	77729881	1	-	27760321	HT29	viability after 13 days	TTTCGGGGGTATTCTCAGCAGG	USP33	ENSG00000077254	-0.7166637459472787	[284,222]	[94,260,181]	-6	hSpCas9	negative selection	5287357
77739370	77739392	1	-	27760321	HT29	viability after 13 days	CCTTACCACTCTTCGAGTATGG	USP33	ENSG00000077254	0.16227146908558754	[346,270]	[445,418,341]	2	hSpCas9	negative selection	5287358
77728331	77728353	1	-	27760321	HT29	viability after 10 days	ACAGTCGACTTAAACAACCAGG	USP33	ENSG00000077254	0.5162746022042639	[118,92]	[225,94,242]	7	hSpCas9	negative selection	5370817
77728610	77728632	1	-	27760321	HT29	viability after 10 days	CCGCAAACCATAACCACTGAGG	USP33	ENSG00000077254	0.5974795170384997	[200,156]	[283,352,376]	7	hSpCas9	negative selection	5370818
77728677	77728699	1	+	27760321	HT29	viability after 10 days	CAAATCCATTAAACATCGAAGG	USP33	ENSG00000077254	-0.08100848950115891	[193,151]	[236,194,180]	-1	hSpCas9	negative selection	5370819
77729859	77729881	1	-	27760321	HT29	viability after 10 days	TTTCGGGGGTATTCTCAGCAGG	USP33	ENSG00000077254	0.18072012197135084	[284,222]	[264,251,553]	2	hSpCas9	negative selection	5370820
77739370	77739392	1	-	27760321	HT29	viability after 10 days	CCTTACCACTCTTCGAGTATGG	USP33	ENSG00000077254	0.3404682807723576	[346,270]	[464,529,471]	4	hSpCas9	negative selection	5370821
77728331	77728353	1	-	27760321	MOLM13	viability	ACAGTCGACTTAAACAACCAGG	USP33	ENSG00000077254	-3.59698955094545	[181,118]	[7,5]	-9	hSpCas9	negative selection	5454280
77728610	77728632	1	-	27760321	MOLM13	viability	CCGCAAACCATAACCACTGAGG	USP33	ENSG00000077254	1.1642714435532582	[274,200]	[121,447]	7	hSpCas9	negative selection	5454281
77728677	77728699	1	+	27760321	MOLM13	viability	CAAATCCATTAAACATCGAAGG	USP33	ENSG00000077254	0.6104654771337326	[206,193]	[255,101]	4	hSpCas9	negative selection	5454282
77729859	77729881	1	-	27760321	MOLM13	viability	TTTCGGGGGTATTCTCAGCAGG	USP33	ENSG00000077254	-0.3295790816238391	[365,284]	[55,220]	-2	hSpCas9	negative selection	5454283
77739370	77739392	1	-	27760321	MOLM13	viability	CCTTACCACTCTTCGAGTATGG	USP33	ENSG00000077254	0.8351352438591417	[377,346]	[138,556]	6	hSpCas9	negative selection	5454284
77759284	77759307	1	+	27661255	K562	viability	GGGACTGGCAAGCCTGAGTGGGG	USP33	ENSG00000077254	-0.21337626883684507	[651,591]	[465,397]	-6	dCas9-KRAB	negative selection	5521830
77759735	77759758	1	+	27661255	K562	viability	GAGAGGGGCAGTGTCGCGTCAGG	USP33	ENSG00000077254	0.12362912747732578	[598,780]	[676,529]	4	dCas9-KRAB	negative selection	5521831
77759750	77759773	1	+	27661255	K562	viability	GCGTCAGGAGGGCCGGAAAACGG	USP33	ENSG00000077254	0.15604099800293803	[408,361]	[338,347]	5	dCas9-KRAB	negative selection	5521832
77759414	77759437	1	-	27661255	K562	viability	GCCCTGTCAACGGTCGGTGGAGG	USP33	ENSG00000077254	0.3867281749827689	[206,248]	[286,194]	9	dCas9-KRAB	negative selection	5521833
77759420	77759443	1	-	27661255	K562	viability	GTGGTCGCCCTGTCAACGGTCGG	USP33	ENSG00000077254	-0.0539871797895517	[649,594]	[543,424]	-2	dCas9-KRAB	negative selection	5521834
77741377	77741400	1	+	27260156	BXPC3	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.30365822453467683	[737]	[773,966,988,1111]	6	hSpCas9	negative selection	5579416
77736090	77736113	1	+	27260156	BXPC3	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	-0.1773527182680541	[323]	[241,319,290,354]	-4	hSpCas9	negative selection	5579417
77736083	77736106	1	-	27260156	BXPC3	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.5364539335740877	[219]	[159,130,170,174]	-8	hSpCas9	negative selection	5579418
77741651	77741674	1	+	27260156	BXPC3	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.5818269977519075	[494]	[345,337,344,352]	-8	hSpCas9	negative selection	5643663
77741664	77741687	1	-	27260156	BXPC3	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	-0.15326178179203542	[348]	[251,341,387,337]	-4	hSpCas9	negative selection	5643664
77741388	77741411	1	-	27260156	BXPC3	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.11195791460626234	[539]	[644,480,597,730]	2	hSpCas9	negative selection	5643665
77741377	77741400	1	+	27260156	A673	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	-0.00818776850156433	[737]	[918,936,766,904]	0	hSpCas9	negative selection	5700667
77736090	77736113	1	+	27260156	A673	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	-0.20492513629613085	[323]	[326,315,374,329]	-5	hSpCas9	negative selection	5700668
77736083	77736106	1	-	27260156	A673	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.09502685384500675	[219]	[294,192,268,237]	-2	hSpCas9	negative selection	5700669
77741651	77741674	1	+	27260156	A673	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.4873200442408465	[494]	[433,406,469,382]	-8	hSpCas9	negative selection	5764914
77741664	77741687	1	-	27260156	A673	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.20266266260921276	[348]	[689,467,341,451]	5	hSpCas9	negative selection	5764915
77741388	77741411	1	-	27260156	A673	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	-0.09658340474170682	[539]	[688,649,617,467]	-2	hSpCas9	negative selection	5764916
77741377	77741400	1	+	27260156	A375	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.16665533202016702	[737]	[736,1249,1060,867]	2	hSpCas9	negative selection	5821918
77736090	77736113	1	+	27260156	A375	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	-0.2710107629208801	[323]	[233,518,267,265]	-4	hSpCas9	negative selection	5821919
77736083	77736106	1	-	27260156	A375	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.7020152821724923	[219]	[207,325,55,74]	-7	hSpCas9	negative selection	5821920
77741651	77741674	1	+	27260156	A375	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.8053994924128051	[494]	[346,441,387,178]	-7	hSpCas9	negative selection	5886165
77741664	77741687	1	-	27260156	A375	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.29079727218409646	[348]	[394,495,411,667]	4	hSpCas9	negative selection	5886166
77741388	77741411	1	-	27260156	A375	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.20355971857351732	[539]	[753,953,488,735]	3	hSpCas9	negative selection	5886167
77741377	77741400	1	+	27260156	COLO741	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	-0.015081951905654645	[737]	[954,1131,727]	0	hSpCas9	negative selection	5943169
77736090	77736113	1	+	27260156	COLO741	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	-0.3137622714319851	[323]	[386,339,279]	-6	hSpCas9	negative selection	5943170
77736083	77736106	1	-	27260156	COLO741	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.1375419427969935	[219]	[243,361,165]	-3	hSpCas9	negative selection	5943171
77741651	77741674	1	+	27260156	COLO741	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.35687140185815963	[494]	[566,473,448]	-6	hSpCas9	negative selection	6007416
77741664	77741687	1	-	27260156	COLO741	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.07368390696582106	[348]	[469,566,376]	1	hSpCas9	negative selection	6007417
77741388	77741411	1	-	27260156	COLO741	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.18691608489580577	[539]	[828,937,604]	4	hSpCas9	negative selection	6007418
77741377	77741400	1	+	27260156	CAL120	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	-0.034754778567997024	[737]	[1289,822,639]	0	hSpCas9	negative selection	6064420
77736090	77736113	1	+	27260156	CAL120	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	0.0564394525804201	[323]	[459,509,295]	0	hSpCas9	negative selection	6064421
77736083	77736106	1	-	27260156	CAL120	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.5985405605569787	[219]	[244,126,179]	-7	hSpCas9	negative selection	6064422
77741651	77741674	1	+	27260156	CAL120	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.5846262860169137	[494]	[511,363,371]	-7	hSpCas9	negative selection	6128667
77741664	77741687	1	-	27260156	CAL120	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	-0.0020695741397998013	[348]	[426,504,368]	0	hSpCas9	negative selection	6128668
77741388	77741411	1	-	27260156	CAL120	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.11447790763632734	[539]	[761,737,687]	1	hSpCas9	negative selection	6128669
77741377	77741400	1	+	27260156	CADOES1	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.20831238486406223	[737]	[815,877,739,735]	3	hSpCas9	negative selection	6185671
77736090	77736113	1	+	27260156	CADOES1	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	0.20344100045871866	[323]	[333,370,360,320]	3	hSpCas9	negative selection	6185672
77736083	77736106	1	-	27260156	CADOES1	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	0.1344467146695465	[219]	[165,168,297,266]	2	hSpCas9	negative selection	6185673
77741651	77741674	1	+	27260156	CADOES1	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.5902383970102987	[494]	[302,322,373,219]	-8	hSpCas9	negative selection	6249918
77741664	77741687	1	-	27260156	CADOES1	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.1767993933756497	[348]	[382,377,380,323]	3	hSpCas9	negative selection	6249919
77741388	77741411	1	-	27260156	CADOES1	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.13456304427368596	[539]	[507,619,489,588]	2	hSpCas9	negative selection	6249920
77741377	77741400	1	+	27260156	EWS502	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.06704320761852711	[737]	[643,818,743,1105]	1	hSpCas9	negative selection	6306922
77736090	77736113	1	+	27260156	EWS502	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	-0.028087398781345807	[323]	[141,492,389,337]	0	hSpCas9	negative selection	6306923
77736083	77736106	1	-	27260156	EWS502	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.2730940464291851	[219]	[140,204,157,277]	-5	hSpCas9	negative selection	6306924
77741651	77741674	1	+	27260156	EWS502	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.7249885504134752	[494]	[265,325,333,349]	-8	hSpCas9	negative selection	6371169
77741664	77741687	1	-	27260156	EWS502	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.09670692022995664	[348]	[454,291,323,512]	1	hSpCas9	negative selection	6371170
77741388	77741411	1	-	27260156	EWS502	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.06528903831236785	[539]	[419,759,674,548]	1	hSpCas9	negative selection	6371171
77741377	77741400	1	+	27260156	EW8	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.07031082196817307	[737]	[598,664,555,698]	1	hSpCas9	negative selection	6428173
77736090	77736113	1	+	27260156	EW8	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	-0.24628286866527327	[323]	[416,224,124,155]	-4	hSpCas9	negative selection	6428174
77736083	77736106	1	-	27260156	EW8	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.27137275754930545	[219]	[171,193,108,124]	-5	hSpCas9	negative selection	6428175
77741651	77741674	1	+	27260156	EW8	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.8579145508306711	[494]	[252,285,141,220]	-9	hSpCas9	negative selection	6492420
77741664	77741687	1	-	27260156	EW8	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.389100221156421	[348]	[518,369,329,284]	7	hSpCas9	negative selection	6492421
77741388	77741411	1	-	27260156	EW8	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.0726814911819463	[539]	[401,602,370,472]	1	hSpCas9	negative selection	6492422
77741377	77741400	1	+	27260156	CORL105	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.08650527737313196	[737]	[807,726,980,1161]	1	hSpCas9	negative selection	6549424
77736090	77736113	1	+	27260156	CORL105	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	-0.06904653275723105	[323]	[339,356,258,472]	-1	hSpCas9	negative selection	6549425
77736083	77736106	1	-	27260156	CORL105	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	0.03320623722055749	[219]	[381,154,273,250]	0	hSpCas9	negative selection	6549426
77741651	77741674	1	+	27260156	CORL105	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.4721921776661471	[494]	[368,344,529,443]	-7	hSpCas9	negative selection	6613671
77741664	77741687	1	-	27260156	CORL105	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.05046719840579972	[348]	[399,326,529,452]	0	hSpCas9	negative selection	6613672
77741388	77741411	1	-	27260156	CORL105	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.046548010412940544	[539]	[726,767,593,513]	0	hSpCas9	negative selection	6613673
77741377	77741400	1	+	27260156	HS294T	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.3011164458862676	[737]	[425,281,341,349]	4	hSpCas9	negative selection	6670675
77736090	77736113	1	+	27260156	HS294T	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	0.34319570412011297	[323]	[153,128,122,244]	4	hSpCas9	negative selection	6670676
77736083	77736106	1	-	27260156	HS294T	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	0.4167909437063233	[219]	[162,149,64,60]	5	hSpCas9	negative selection	6670677
77741651	77741674	1	+	27260156	HS294T	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.5009210913156709	[494]	[129,120,117,179]	-6	hSpCas9	negative selection	6734922
77741664	77741687	1	-	27260156	HS294T	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	-0.22383211781202983	[348]	[83,94,138,153]	-3	hSpCas9	negative selection	6734923
77741388	77741411	1	-	27260156	HS294T	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	-0.18251129007000855	[539]	[115,186,233,208]	-3	hSpCas9	negative selection	6734924
77741377	77741400	1	+	27260156	HCC44	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	-0.2048984862717244	[737]	[706,660,751,780]	-3	hSpCas9	negative selection	6791926
77736090	77736113	1	+	27260156	HCC44	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	-0.32824922783837196	[323]	[389,276,298,213]	-5	hSpCas9	negative selection	6791927
77736083	77736106	1	-	27260156	HCC44	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-1.4402764535889852	[219]	[69,63,74,153]	-9	hSpCas9	negative selection	6791928
77741651	77741674	1	+	27260156	HCC44	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-1.2190770664888217	[494]	[476,142,240,137]	-9	hSpCas9	negative selection	6856173
77741664	77741687	1	-	27260156	HCC44	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.061259933898366425	[348]	[308,190,421,734]	0	hSpCas9	negative selection	6856174
77741388	77741411	1	-	27260156	HCC44	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.3473655488749575	[539]	[664,764,949,743]	5	hSpCas9	negative selection	6856175
77741377	77741400	1	+	27260156	G402	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.02874215703814531	[737]	[1020,1197,882,614]	0	hSpCas9	negative selection	6913177
77736090	77736113	1	+	27260156	G402	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	0.24782891986239436	[323]	[391,304,175,957]	3	hSpCas9	negative selection	6913178
77736083	77736106	1	-	27260156	G402	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.2645669925942682	[219]	[173,335,192,190]	-3	hSpCas9	negative selection	6913179
77741651	77741674	1	+	27260156	G402	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.5814844708511132	[494]	[494,630,270,249]	-6	hSpCas9	negative selection	6977424
77741664	77741687	1	-	27260156	G402	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.3596949004550796	[348]	[590,639,301,656]	4	hSpCas9	negative selection	6977425
77741388	77741411	1	-	27260156	G402	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	-0.17208698424729552	[539]	[361,803,469,676]	-2	hSpCas9	negative selection	6977426
77741377	77741400	1	+	27260156	L33	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.0543137081558297	[737]	[859,276,481,759]	1	hSpCas9	negative selection	7034428
77736090	77736113	1	+	27260156	L33	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	0.1677857706266691	[323]	[371,139,220,389]	3	hSpCas9	negative selection	7034429
77736083	77736106	1	-	27260156	L33	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.07799040229516052	[219]	[275,87,101,178]	-2	hSpCas9	negative selection	7034430
77741651	77741674	1	+	27260156	L33	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.35929201443535685	[494]	[317,150,274,420]	-7	hSpCas9	negative selection	7098675
77741664	77741687	1	-	27260156	L33	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	-0.3137099743899703	[348]	[261,116,159,320]	-6	hSpCas9	negative selection	7098676
77741388	77741411	1	-	27260156	L33	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	-0.3473309624190236	[539]	[413,209,302,290]	-7	hSpCas9	negative selection	7098677
77741377	77741400	1	+	27260156	K562	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.5929015881961711	[737]	[751,765,1258,1122]	7	hSpCas9	negative selection	7155679
77736090	77736113	1	+	27260156	K562	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	-0.41905719770803485	[323]	[196,386,144,145]	-5	hSpCas9	negative selection	7155680
77736083	77736106	1	-	27260156	K562	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	0.2588134675463436	[219]	[347,236,124,232]	3	hSpCas9	negative selection	7155681
77741651	77741674	1	+	27260156	K562	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.23118722526430352	[494]	[301,324,505,355]	-3	hSpCas9	negative selection	7219926
77741664	77741687	1	-	27260156	K562	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	-0.18635438455212627	[348]	[200,331,327,228]	-2	hSpCas9	negative selection	7219927
77741388	77741411	1	-	27260156	K562	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.2986588112291576	[539]	[552,641,749,428]	4	hSpCas9	negative selection	7219928
77741377	77741400	1	+	27260156	HT29	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.2917482565790106	[737]	[1365,1216,1016,846]	6	hSpCas9	negative selection	7276930
77736090	77736113	1	+	27260156	HT29	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	-0.08245291378144393	[323]	[384,476,366,277]	-2	hSpCas9	negative selection	7276931
77736083	77736106	1	-	27260156	HT29	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.07699295396481909	[219]	[355,219,238,207]	-2	hSpCas9	negative selection	7276932
77741651	77741674	1	+	27260156	HT29	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.5415592685203293	[494]	[390,388,553,323]	-7	hSpCas9	negative selection	7341177
77741664	77741687	1	-	27260156	HT29	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.10091547200562234	[348]	[447,483,551,347]	2	hSpCas9	negative selection	7341178
77741388	77741411	1	-	27260156	HT29	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.13600034218909793	[539]	[826,738,748,590]	2	hSpCas9	negative selection	7341179
77741377	77741400	1	+	27260156	MHHES1	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	-0.07522862282110054	[737]	[1069,1011,603,560]	-1	hSpCas9	negative selection	7398181
77736090	77736113	1	+	27260156	MHHES1	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	0.043560219408737944	[323]	[307,412,387,380]	0	hSpCas9	negative selection	7398182
77736083	77736106	1	-	27260156	MHHES1	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.20881063347663753	[219]	[204,359,144,166]	-4	hSpCas9	negative selection	7398183
77741651	77741674	1	+	27260156	MHHES1	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.4255304423113068	[494]	[516,439,369,352]	-7	hSpCas9	negative selection	7462428
77741664	77741687	1	-	27260156	MHHES1	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	-0.32195449681008814	[348]	[345,471,277,200]	-6	hSpCas9	negative selection	7462429
77741388	77741411	1	-	27260156	MHHES1	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.12788368970784278	[539]	[806,741,617,531]	2	hSpCas9	negative selection	7462430
77741377	77741400	1	+	27260156	MEWO	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.02932762617608098	[737]	[736,701,680]	0	hSpCas9	negative selection	7519432
77736090	77736113	1	+	27260156	MEWO	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	-0.012207423612021984	[323]	[287,341,268]	0	hSpCas9	negative selection	7519433
77736083	77736106	1	-	27260156	MEWO	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	0.5633241194603045	[219]	[375,359,189]	9	hSpCas9	negative selection	7519434
77741651	77741674	1	+	27260156	MEWO	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.3918846389497252	[494]	[447,388,239]	-7	hSpCas9	negative selection	7583679
77741664	77741687	1	-	27260156	MEWO	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	-0.27684857134994567	[348]	[235,258,306]	-6	hSpCas9	negative selection	7583680
77741388	77741411	1	-	27260156	MEWO	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	-0.18637263576813043	[539]	[463,385,485]	-4	hSpCas9	negative selection	7583681
77741377	77741400	1	+	27260156	LNCAPCLONEFGC	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	-0.09874783847235169	[737]	[643,546,829,510]	-1	hSpCas9	negative selection	7640683
77736090	77736113	1	+	27260156	LNCAPCLONEFGC	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	0.18168614584335474	[323]	[272,233,298,527]	3	hSpCas9	negative selection	7640684
77736083	77736106	1	-	27260156	LNCAPCLONEFGC	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.53173599076262	[219]	[103,96,166,190]	-7	hSpCas9	negative selection	7640685
77741651	77741674	1	+	27260156	LNCAPCLONEFGC	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.7297703745800456	[494]	[255,253,305,271]	-8	hSpCas9	negative selection	7704930
77741664	77741687	1	-	27260156	LNCAPCLONEFGC	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.1207764086572995	[348]	[399,352,430,201]	1	hSpCas9	negative selection	7704931
77741388	77741411	1	-	27260156	LNCAPCLONEFGC	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	-0.28226755513757784	[539]	[379,342,455,441]	-4	hSpCas9	negative selection	7704932
77741377	77741400	1	+	27260156	PANC0327	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.18013188885392384	[737]	[904,681,745,658]	2	hSpCas9	negative selection	7761934
77736090	77736113	1	+	27260156	PANC0327	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	0.07273308510789711	[323]	[463,255,301,207]	1	hSpCas9	negative selection	7761935
77736083	77736106	1	-	27260156	PANC0327	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	0.4823530064168269	[219]	[518,125,199,285]	7	hSpCas9	negative selection	7761936
77741651	77741674	1	+	27260156	PANC0327	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.39310809556640836	[494]	[544,275,269,272]	-5	hSpCas9	negative selection	7826181
77741664	77741687	1	-	27260156	PANC0327	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.2530059916536983	[348]	[299,469,355,332]	4	hSpCas9	negative selection	7826182
77741388	77741411	1	-	27260156	PANC0327	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	-0.009766568135819442	[539]	[479,328,529,585]	0	hSpCas9	negative selection	7826183
77741377	77741400	1	+	27260156	NCIH2009	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.35207544097743215	[737]	[1213,867,1851]	5	hSpCas9	negative selection	7883185
77736090	77736113	1	+	27260156	NCIH2009	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	0.17262616783980522	[323]	[480,565,475]	2	hSpCas9	negative selection	7883186
77736083	77736106	1	-	27260156	NCIH2009	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.9724644878180457	[219]	[318,143,38]	-8	hSpCas9	negative selection	7883187
77741651	77741674	1	+	27260156	NCIH2009	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.45693008753777475	[494]	[1034,375,206]	-5	hSpCas9	negative selection	7947432
77741664	77741687	1	-	27260156	NCIH2009	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.1550088411022964	[348]	[644,432,571]	2	hSpCas9	negative selection	7947433
77741388	77741411	1	-	27260156	NCIH2009	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	-0.26370722418178905	[539]	[686,616,591]	-4	hSpCas9	negative selection	7947434
77741377	77741400	1	+	27260156	NCIH1373	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	-0.8086353978533799	[737]	[593,434,528,89]	-7	hSpCas9	negative selection	8004436
77736090	77736113	1	+	27260156	NCIH1373	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	-0.353265278604051	[323]	[368,156,237,106]	-4	hSpCas9	negative selection	8004437
77736083	77736106	1	-	27260156	NCIH1373	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.9897402456186477	[219]	[57,37,210,49]	-7	hSpCas9	negative selection	8004438
77741651	77741674	1	+	27260156	NCIH1373	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.49324202677965034	[494]	[503,428,282,97]	-5	hSpCas9	negative selection	8068683
77741664	77741687	1	-	27260156	NCIH1373	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	-0.16977568487182382	[348]	[393,263,420,84]	-2	hSpCas9	negative selection	8068684
77741388	77741411	1	-	27260156	NCIH1373	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.23560076671296773	[539]	[891,749,723,128]	2	hSpCas9	negative selection	8068685
77741377	77741400	1	+	27260156	PATU8902	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.066975818523478	[737]	[1098,953,924,1396]	0	hSpCas9	negative selection	8125687
77736090	77736113	1	+	27260156	PATU8902	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	-1.4504193450385925	[323]	[203,83,217,134]	-8	hSpCas9	negative selection	8125688
77736083	77736106	1	-	27260156	PATU8902	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.9061175712808744	[219]	[168,181,54,289]	-7	hSpCas9	negative selection	8125689
77741651	77741674	1	+	27260156	PATU8902	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.9941905858517022	[494]	[252,692,311,105]	-7	hSpCas9	negative selection	8189934
77741664	77741687	1	-	27260156	PATU8902	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.38646497020419884	[348]	[728,342,760,672]	4	hSpCas9	negative selection	8189935
77741388	77741411	1	-	27260156	PATU8902	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.7990625931696794	[539]	[1079,1507,1153,1554]	8	hSpCas9	negative selection	8189936
77741377	77741400	1	+	27260156	PANC1	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.08974083807730948	[737]	[612,743,753,603]	1	hSpCas9	negative selection	8246938
77736090	77736113	1	+	27260156	PANC1	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	-0.34218525601825767	[323]	[236,184,304,151]	-5	hSpCas9	negative selection	8246939
77736083	77736106	1	-	27260156	PANC1	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.20164993662655095	[219]	[225,241,114,96]	-3	hSpCas9	negative selection	8246940
77741651	77741674	1	+	27260156	PANC1	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.6428560113045245	[494]	[266,199,361,245]	-7	hSpCas9	negative selection	8311185
77741664	77741687	1	-	27260156	PANC1	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.12384108342244748	[348]	[248,491,405,209]	2	hSpCas9	negative selection	8311186
77741388	77741411	1	-	27260156	PANC1	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.2542871431418735	[539]	[469,616,745,410]	4	hSpCas9	negative selection	8311187
77741377	77741400	1	+	27260156	PANC0813	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.031900763542828225	[737]	[1008,725,997,825]	0	hSpCas9	negative selection	8368189
77736090	77736113	1	+	27260156	PANC0813	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	-0.07642716703416197	[323]	[394,368,335,346]	-1	hSpCas9	negative selection	8368190
77736083	77736106	1	-	27260156	PANC0813	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	0.18817053388835359	[219]	[300,190,282,396]	3	hSpCas9	negative selection	8368191
77741651	77741674	1	+	27260156	PANC0813	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.5430448025890336	[494]	[548,334,546,190]	-7	hSpCas9	negative selection	8432436
77741664	77741687	1	-	27260156	PANC0813	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.0533104575353916	[348]	[408,466,360,459]	0	hSpCas9	negative selection	8432437
77741388	77741411	1	-	27260156	PANC0813	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.17904427766968886	[539]	[650,811,651,747]	3	hSpCas9	negative selection	8432438
77741377	77741400	1	+	27260156	RDES	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.00016219059201327823	[737]	[732,726,853,1135]	0	hSpCas9	negative selection	8489440
77736090	77736113	1	+	27260156	RDES	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	-0.5070315049350256	[323]	[239,264,249,293]	-7	hSpCas9	negative selection	8489441
77736083	77736106	1	-	27260156	RDES	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.39462324664999393	[219]	[174,132,228,245]	-6	hSpCas9	negative selection	8489442
77741651	77741674	1	+	27260156	RDES	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.8665364532188627	[494]	[253,288,406,306]	-9	hSpCas9	negative selection	8553687
77741664	77741687	1	-	27260156	RDES	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.27570760291189195	[348]	[338,338,624,713]	4	hSpCas9	negative selection	8553688
77741388	77741411	1	-	27260156	RDES	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.02040140367404944	[539]	[564,579,596,800]	0	hSpCas9	negative selection	8553689
77741377	77741400	1	+	27260156	PC3	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.08292062050748172	[737]	[763,629,1196,580]	2	hSpCas9	negative selection	8610691
77736090	77736113	1	+	27260156	PC3	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	-0.030499902119270228	[323]	[150,321,682,298]	0	hSpCas9	negative selection	8610692
77736083	77736106	1	-	27260156	PC3	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.5385195418042132	[219]	[105,197,142,153]	-8	hSpCas9	negative selection	8610693
77741651	77741674	1	+	27260156	PC3	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.8621626329375767	[494]	[159,259,541,252]	-9	hSpCas9	negative selection	8674938
77741664	77741687	1	-	27260156	PC3	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	-0.26797563524196943	[348]	[158,304,575,256]	-6	hSpCas9	negative selection	8674939
77741388	77741411	1	-	27260156	PC3	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.1213276011566223	[539]	[334,572,1083,602]	2	hSpCas9	negative selection	8674940
77741377	77741400	1	+	27260156	PATU8988T	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	-0.13427437245964058	[737]	[476,822,663,650]	-2	hSpCas9	negative selection	8731942
77736090	77736113	1	+	27260156	PATU8988T	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	0.434667213180949	[323]	[421,588,374,313]	7	hSpCas9	negative selection	8731943
77736083	77736106	1	-	27260156	PATU8988T	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.16168653661977417	[219]	[155,176,247,175]	-3	hSpCas9	negative selection	8731944
77741651	77741674	1	+	27260156	PATU8988T	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	0.01918200444513414	[494]	[303,489,392,776]	0	hSpCas9	negative selection	8796189
77741664	77741687	1	-	27260156	PATU8988T	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	-0.042962121986236335	[348]	[298,321,343,344]	0	hSpCas9	negative selection	8796190
77741388	77741411	1	-	27260156	PATU8988T	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.04428383589522869	[539]	[399,860,409,510]	0	hSpCas9	negative selection	8796191
77741377	77741400	1	+	27260156	T47D	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.3089987629321618	[737]	[1123,959,1111,1072]	6	hSpCas9	negative selection	8853193
77736090	77736113	1	+	27260156	T47D	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	-0.18289463574593123	[323]	[340,233,348,416]	-4	hSpCas9	negative selection	8853194
77736083	77736106	1	-	27260156	T47D	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.12017276417321687	[219]	[228,279,213,215]	-3	hSpCas9	negative selection	8853195
77741651	77741674	1	+	27260156	T47D	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.4502060848964132	[494]	[487,345,394,467]	-7	hSpCas9	negative selection	8917440
77741664	77741687	1	-	27260156	T47D	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.2101432238008635	[348]	[490,571,430,375]	4	hSpCas9	negative selection	8917441
77741388	77741411	1	-	27260156	T47D	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.23995923383393566	[539]	[649,626,831,874]	5	hSpCas9	negative selection	8917442
77741377	77741400	1	+	27260156	SU8686	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.3167113412744812	[737]	[991,841,814,1000]	5	hSpCas9	negative selection	8974444
77736090	77736113	1	+	27260156	SU8686	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	0.2792884188876916	[323]	[352,390,374,450]	5	hSpCas9	negative selection	8974445
77736083	77736106	1	-	27260156	SU8686	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	0.11278573535057324	[219]	[269,184,277,207]	2	hSpCas9	negative selection	8974446
77741651	77741674	1	+	27260156	SU8686	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.087318329780552	[494]	[372,486,307,720]	-1	hSpCas9	negative selection	9038691
77741664	77741687	1	-	27260156	SU8686	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.021432616555841777	[348]	[242,251,438,523]	0	hSpCas9	negative selection	9038692
77741388	77741411	1	-	27260156	SU8686	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.3348349627913133	[539]	[675,611,716,704]	5	hSpCas9	negative selection	9038693
77741377	77741400	1	+	27260156	SKES1	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.012136152357987595	[737]	[817,806,804,569]	0	hSpCas9	negative selection	9095695
77736090	77736113	1	+	27260156	SKES1	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	-0.449997026195625	[323]	[220,253,264,206]	-7	hSpCas9	negative selection	9095696
77736083	77736106	1	-	27260156	SKES1	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.4223253526148578	[219]	[160,177,122,189]	-7	hSpCas9	negative selection	9095697
77741651	77741674	1	+	27260156	SKES1	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.6328116229479088	[494]	[410,331,264,281]	-8	hSpCas9	negative selection	9159942
77741664	77741687	1	-	27260156	SKES1	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	-0.1492453653102802	[348]	[324,296,296,330]	-3	hSpCas9	negative selection	9159943
77741388	77741411	1	-	27260156	SKES1	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.0007421607971335731	[539]	[594,473,552,528]	0	hSpCas9	negative selection	9159944
77741377	77741400	1	+	27260156	TOV112D	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.22870861877366855	[737]	[930,1181,775,662]	4	hSpCas9	negative selection	9216946
77736090	77736113	1	+	27260156	TOV112D	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	-0.1241617604255344	[323]	[336,408,243,232]	-2	hSpCas9	negative selection	9216947
77736083	77736106	1	-	27260156	TOV112D	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.12647280635671931	[219]	[217,255,263,86]	-2	hSpCas9	negative selection	9216948
77741651	77741674	1	+	27260156	TOV112D	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.9847563304404412	[494]	[260,247,317,176]	-9	hSpCas9	negative selection	9281193
77741664	77741687	1	-	27260156	TOV112D	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	-0.021234712828248625	[348]	[423,338,400,221]	0	hSpCas9	negative selection	9281194
77741388	77741411	1	-	27260156	TOV112D	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	-0.03813914166716262	[539]	[529,589,551,451]	0	hSpCas9	negative selection	9281195
77741377	77741400	1	+	27260156	TC71	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	0.1043489406308874	[737]	[814,778,914,893]	2	hSpCas9	negative selection	9338197
77736090	77736113	1	+	27260156	TC71	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	-0.24726988461372423	[323]	[317,308,292,246]	-6	hSpCas9	negative selection	9338198
77736083	77736106	1	-	27260156	TC71	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.3275860868590261	[219]	[195,183,189,180]	-7	hSpCas9	negative selection	9338199
77741651	77741674	1	+	27260156	TC71	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.38020678864051854	[494]	[425,409,356,440]	-8	hSpCas9	negative selection	9402444
77741664	77741687	1	-	27260156	TC71	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	-0.08746043643826262	[348]	[346,384,318,358]	-2	hSpCas9	negative selection	9402445
77741388	77741411	1	-	27260156	TC71	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.09680310685396118	[539]	[693,585,593,599]	2	hSpCas9	negative selection	9402446
77741377	77741400	1	+	27260156	TC32	viability	TCCAGACATGCCCAAAGATTTGG	USP33	ENSG00000077254	-0.1612223835170874	[737]	[543,546,825,596]	-3	hSpCas9	negative selection	9459448
77736090	77736113	1	+	27260156	TC32	viability	TATATCCAGATCATCAAATACGG	USP33	ENSG00000077254	-0.024288477088597826	[323]	[222,257,455,294]	0	hSpCas9	negative selection	9459449
77736083	77736106	1	-	27260156	TC32	viability	TGATGATCTGGATATAGAAGCGG	USP33	ENSG00000077254	-0.17305393490594922	[219]	[190,143,310,107]	-3	hSpCas9	negative selection	9459450
77741651	77741674	1	+	27260156	TC32	viability	TCACCAACTGAATCCAAATGTGG	USP33	ENSG00000077254	-0.8159496509739981	[494]	[235,213,275,343]	-9	hSpCas9	negative selection	9523695
77741664	77741687	1	-	27260156	TC32	viability	TCGAAATCATTGTCCACATTTGG	USP33	ENSG00000077254	0.006620634009588844	[348]	[312,198,524,348]	0	hSpCas9	negative selection	9523696
77741388	77741411	1	-	27260156	TC32	viability	AAGTCCAAGGACCAAATCTTTGG	USP33	ENSG00000077254	0.0041137298680892775	[539]	[512,384,564,602]	0	hSpCas9	negative selection	9523697
77711820	77711843	1	+	27869803	HPAFII	viability after 27 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	0.1098119239392148	[157]	[33,135,NaN]	0	hSpCas9	negative selection	9535641
77714652	77714675	1	-	27869803	HPAFII	viability after 27 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	0.6231397862171824	[204]	[195,140,NaN]	5	hSpCas9	negative selection	9535642
77722057	77722080	1	-	27869803	HPAFII	viability after 27 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	-1.786034652513122	[129]	[3,32,NaN]	-8	hSpCas9	negative selection	9535643
77723330	77723353	1	-	27869803	HPAFII	viability after 27 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	-0.5166429300422073	[518]	[271,122,NaN]	-4	hSpCas9	negative selection	9535644
77725645	77725668	1	-	27869803	HPAFII	viability after 27 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	1.8139236725801364	[68]	[90,157,NaN]	9	hSpCas9	negative selection	9535645
77736100	77736123	1	+	27869803	HPAFII	viability after 27 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	0.1513243465752806	[484]	[400,184,NaN]	1	hSpCas9	negative selection	9535646
77711820	77711843	1	+	27869803	HPAFII	viability after 15 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	0.21043588230679633	[157]	[267,151,NaN]	2	hSpCas9	negative selection	9618090
77714652	77714675	1	-	27869803	HPAFII	viability after 15 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	0.5825356592937091	[204]	[406,281,NaN]	6	hSpCas9	negative selection	9618091
77722057	77722080	1	-	27869803	HPAFII	viability after 15 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	-1.1379785709413857	[129]	[89,46,NaN]	-8	hSpCas9	negative selection	9618092
77723330	77723353	1	-	27869803	HPAFII	viability after 15 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	-0.8993076149770881	[518]	[504,170,NaN]	-7	hSpCas9	negative selection	9618093
77725645	77725668	1	-	27869803	HPAFII	viability after 15 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	0.8295182811485995	[68]	[124,135,NaN]	8	hSpCas9	negative selection	9618094
77736100	77736123	1	+	27869803	HPAFII	viability after 15 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	-0.010685874039715215	[484]	[665,424,NaN]	0	hSpCas9	negative selection	9618095
77711820	77711843	1	+	27869803	ASPC1	viability after 36 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	1.183185237584866	[431]	[635,272,187]	9	hSpCas9	negative selection	9700539
77714652	77714675	1	-	27869803	ASPC1	viability after 36 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	0.3059610311598301	[628]	[275,281,256]	3	hSpCas9	negative selection	9700540
77722057	77722080	1	-	27869803	ASPC1	viability after 36 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	0.6041595958256102	[332]	[77,332,119]	6	hSpCas9	negative selection	9700541
77723330	77723353	1	-	27869803	ASPC1	viability after 36 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	0.08305816095559426	[1268]	[712,199,506]	0	hSpCas9	negative selection	9700542
77725645	77725668	1	-	27869803	ASPC1	viability after 36 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	-0.6072651247769804	[329]	[0,129,83]	-6	hSpCas9	negative selection	9700543
77736100	77736123	1	+	27869803	ASPC1	viability after 36 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	0.3759193613819438	[1018]	[890,436,174]	4	hSpCas9	negative selection	9700544
77711820	77711843	1	+	27869803	PATU8988S	viability after 35 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	1.5348841900705494	[367]	[414,443,NaN]	9	hSpCas9	negative selection	9782988
77714652	77714675	1	-	27869803	PATU8988S	viability after 35 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	0.8209669258583253	[525]	[262,485,NaN]	8	hSpCas9	negative selection	9782989
77722057	77722080	1	-	27869803	PATU8988S	viability after 35 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	0.5813835403785093	[268]	[208,114,NaN]	6	hSpCas9	negative selection	9782990
77723330	77723353	1	-	27869803	PATU8988S	viability after 35 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	0.13543146195922362	[1095]	[641,326,NaN]	1	hSpCas9	negative selection	9782991
77725645	77725668	1	-	27869803	PATU8988S	viability after 35 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	1.1594871752634097	[272]	[291,198,NaN]	9	hSpCas9	negative selection	9782992
77736100	77736123	1	+	27869803	PATU8988S	viability after 35 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	0.010634689569505529	[865]	[290,411,NaN]	0	hSpCas9	negative selection	9782993
77711820	77711843	1	+	27869803	PATU8988S	viability after 31 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	1.0740929721455856	[367]	[216,425,NaN]	9	hSpCas9	negative selection	9865437
77714652	77714675	1	-	27869803	PATU8988S	viability after 31 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	0.4763080372663684	[525]	[216,386,NaN]	6	hSpCas9	negative selection	9865438
77722057	77722080	1	-	27869803	PATU8988S	viability after 31 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	0.4027462357527667	[268]	[154,124,NaN]	5	hSpCas9	negative selection	9865439
77723330	77723353	1	-	27869803	PATU8988S	viability after 31 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	-0.17237733957055046	[1095]	[411,356,NaN]	-2	hSpCas9	negative selection	9865440
77725645	77725668	1	-	27869803	PATU8988S	viability after 31 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	0.5422657828916544	[272]	[176,134,NaN]	6	hSpCas9	negative selection	9865441
77736100	77736123	1	+	27869803	PATU8988S	viability after 31 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	-0.121107179199751	[865]	[258,391,NaN]	-1	hSpCas9	negative selection	9865442
77711820	77711843	1	+	27869803	HPAFII	viability after 35 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	-0.27393243310550597	[157]	[20,116,NaN]	-2	hSpCas9	negative selection	9947886
77714652	77714675	1	-	27869803	HPAFII	viability after 35 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	0.8965420281634319	[204]	[235,144,NaN]	6	hSpCas9	negative selection	9947887
77722057	77722080	1	-	27869803	HPAFII	viability after 35 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	-1.581106862496768	[129]	[13,30,NaN]	-7	hSpCas9	negative selection	9947888
77723330	77723353	1	-	27869803	HPAFII	viability after 35 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	-0.8396541844888545	[518]	[127,167,NaN]	-5	hSpCas9	negative selection	9947889
77725645	77725668	1	-	27869803	HPAFII	viability after 35 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	2.1190886192403897	[68]	[115,191,NaN]	9	hSpCas9	negative selection	9947890
77736100	77736123	1	+	27869803	HPAFII	viability after 35 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	0.49469454352211584	[484]	[376,310,NaN]	3	hSpCas9	negative selection	9947891
77711820	77711843	1	+	27869803	HPAFII	viability after 31 days	ATGTACAGATGGTTGACAGCTGG	USP33	ENSG00000077254	0.3577722813583998	[157]	[82,146,NaN]	2	hSpCas9	negative selection	10030335
77714652	77714675	1	-	27869803	HPAFII	viability after 31 days	TTTAAGACCTTTGCCGAACCTGG	USP33	ENSG00000077254	0.7952203619154974	[204]	[202,195,NaN]	6	hSpCas9	negative selection	10030336
77722057	77722080	1	-	27869803	HPAFII	viability after 31 days	GGCGAAGCATATGCTCCACAAGG	USP33	ENSG00000077254	-2.741795283501312	[129]	[19,0,NaN]	-8	hSpCas9	negative selection	10030337
77723330	77723353	1	-	27869803	HPAFII	viability after 31 days	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	-0.6048575203127757	[518]	[191,190,NaN]	-4	hSpCas9	negative selection	10030338
77725645	77725668	1	-	27869803	HPAFII	viability after 31 days	AAATCAGGCAATTTGTGGCCAGG	USP33	ENSG00000077254	2.025166614624759	[68]	[137,178,NaN]	9	hSpCas9	negative selection	10030339
77736100	77736123	1	+	27869803	HPAFII	viability after 31 days	TCATCAAATACGGCAACCAGAGG	USP33	ENSG00000077254	0.06261930601815358	[484]	[345,216,NaN]	0	hSpCas9	negative selection	10030340
77725669	77725692	1	+	28162770	P31FUJ	viability	GGAGGGCTTGCCGATAAACGTGG	USP33	ENSG00000077254	0.4472075049397518	[92]	[148]	5	hSpCas9	negative selection	10262358
77736055	77736078	1	-	28162770	P31FUJ	viability	GAAGATGAACTTAGGGCCAGAGG	USP33	ENSG00000077254	0.46812631435510244	[226]	[368]	5	hSpCas9	negative selection	10262359
77722053	77722076	1	-	28162770	P31FUJ	viability	AAGCATATGCTCCACAAGGGTGG	USP33	ENSG00000077254	0.3595854029740386	[322]	[486]	4	hSpCas9	negative selection	10262360
77741375	77741398	1	-	28162770	P31FUJ	viability	AAATCTTTGGGCATGTCTGGAGG	USP33	ENSG00000077254	-0.02025756903427811	[62]	[72]	0	hSpCas9	negative selection	10262361
77739364	77739387	1	+	28162770	P31FUJ	viability	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	-0.2134368795474476	[147]	[149]	-2	hSpCas9	negative selection	10262362
77729915	77729938	1	+	28162770	P31FUJ	viability	GTAGTAGGCACAACAGATCCTGG	USP33	ENSG00000077254	0.13990988539094373	[440]	[570]	1	hSpCas9	negative selection	10262363
77723330	77723353	1	-	28162770	P31FUJ	viability	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	0.5470351970128353	[861]	[1479]	6	hSpCas9	negative selection	10262364
77717926	77717949	1	+	28162770	P31FUJ	viability	GGACTATCCTTAGCAAGAAATGG	USP33	ENSG00000077254	1.053398185998458	[416]	[1016]	9	hSpCas9	negative selection	10262365
77714767	77714790	1	-	28162770	P31FUJ	viability	TAATAGGAAGAGCAGCGAAGAGG	USP33	ENSG00000077254	0.010575242051405073	[233]	[276]	0	hSpCas9	negative selection	10262366
77711794	77711817	1	-	28162770	P31FUJ	viability	TCATACTTGCCAAATTGAGGCGG	USP33	ENSG00000077254	0.323831573248283	[239]	[352]	3	hSpCas9	negative selection	10262367
77725669	77725692	1	+	28162770	TF1	viability	GGAGGGCTTGCCGATAAACGTGG	USP33	ENSG00000077254	NaN	[NaN]	[94]	1	hSpCas9	negative selection	10431724
77736055	77736078	1	-	28162770	TF1	viability	GAAGATGAACTTAGGGCCAGAGG	USP33	ENSG00000077254	NaN	[NaN]	[235]	1	hSpCas9	negative selection	10431725
77722053	77722076	1	-	28162770	TF1	viability	AAGCATATGCTCCACAAGGGTGG	USP33	ENSG00000077254	NaN	[NaN]	[134]	1	hSpCas9	negative selection	10431726
77741375	77741398	1	-	28162770	TF1	viability	AAATCTTTGGGCATGTCTGGAGG	USP33	ENSG00000077254	NaN	[NaN]	[97]	1	hSpCas9	negative selection	10431727
77739364	77739387	1	+	28162770	TF1	viability	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	NaN	[NaN]	[250]	1	hSpCas9	negative selection	10431728
77729915	77729938	1	+	28162770	TF1	viability	GTAGTAGGCACAACAGATCCTGG	USP33	ENSG00000077254	NaN	[NaN]	[257]	1	hSpCas9	negative selection	10431729
77723330	77723353	1	-	28162770	TF1	viability	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	NaN	[NaN]	[601]	1	hSpCas9	negative selection	10431730
77717926	77717949	1	+	28162770	TF1	viability	GGACTATCCTTAGCAAGAAATGG	USP33	ENSG00000077254	NaN	[NaN]	[388]	1	hSpCas9	negative selection	10431731
77714767	77714790	1	-	28162770	TF1	viability	TAATAGGAAGAGCAGCGAAGAGG	USP33	ENSG00000077254	NaN	[NaN]	[217]	1	hSpCas9	negative selection	10431732
77711794	77711817	1	-	28162770	TF1	viability	TCATACTTGCCAAATTGAGGCGG	USP33	ENSG00000077254	NaN	[NaN]	[77]	1	hSpCas9	negative selection	10431733
77725669	77725692	1	+	28162770	SKM1	viability	GGAGGGCTTGCCGATAAACGTGG	USP33	ENSG00000077254	-1.391367343692143	[45]	[30]	-7	hSpCas9	negative selection	10601090
77736055	77736078	1	-	28162770	SKM1	viability	GAAGATGAACTTAGGGCCAGAGG	USP33	ENSG00000077254	1.0447317711145303	[50]	[185]	8	hSpCas9	negative selection	10601091
77722053	77722076	1	-	28162770	SKM1	viability	AAGCATATGCTCCACAAGGGTGG	USP33	ENSG00000077254	-0.635123563298496	[93]	[106]	-5	hSpCas9	negative selection	10601092
77741375	77741398	1	-	28162770	SKM1	viability	AAATCTTTGGGCATGTCTGGAGG	USP33	ENSG00000077254	-0.3455636540790181	[22]	[31]	-3	hSpCas9	negative selection	10601093
77739364	77739387	1	+	28162770	SKM1	viability	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	0.4246382695611196	[58]	[139]	4	hSpCas9	negative selection	10601094
77729915	77729938	1	+	28162770	SKM1	viability	GTAGTAGGCACAACAGATCCTGG	USP33	ENSG00000077254	-0.01007404617457719	[134]	[236]	0	hSpCas9	negative selection	10601095
77723330	77723353	1	-	28162770	SKM1	viability	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	0.1446782287779682	[218]	[427]	1	hSpCas9	negative selection	10601096
77717926	77717949	1	+	28162770	SKM1	viability	GGACTATCCTTAGCAAGAAATGG	USP33	ENSG00000077254	0.4641552658435347	[97]	[238]	4	hSpCas9	negative selection	10601097
77714767	77714790	1	-	28162770	SKM1	viability	TAATAGGAAGAGCAGCGAAGAGG	USP33	ENSG00000077254	0.04234320262042818	[38]	[70]	0	hSpCas9	negative selection	10601098
77711794	77711817	1	-	28162770	SKM1	viability	TCATACTTGCCAAATTGAGGCGG	USP33	ENSG00000077254	0.138105574854482	[54]	[106]	1	hSpCas9	negative selection	10601099
77725669	77725692	1	+	28162770	SKM1	viability	GGAGGGCTTGCCGATAAACGTGG	USP33	ENSG00000077254	-1.391367343692143	[45]	[30]	-7	hSpCas9	negative selection	10770456
77736055	77736078	1	-	28162770	SKM1	viability	GAAGATGAACTTAGGGCCAGAGG	USP33	ENSG00000077254	1.0447317711145303	[50]	[185]	8	hSpCas9	negative selection	10770457
77722053	77722076	1	-	28162770	SKM1	viability	AAGCATATGCTCCACAAGGGTGG	USP33	ENSG00000077254	-0.635123563298496	[93]	[106]	-5	hSpCas9	negative selection	10770458
77741375	77741398	1	-	28162770	SKM1	viability	AAATCTTTGGGCATGTCTGGAGG	USP33	ENSG00000077254	-0.3455636540790181	[22]	[31]	-3	hSpCas9	negative selection	10770459
77739364	77739387	1	+	28162770	SKM1	viability	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	0.4246382695611196	[58]	[139]	4	hSpCas9	negative selection	10770460
77729915	77729938	1	+	28162770	SKM1	viability	GTAGTAGGCACAACAGATCCTGG	USP33	ENSG00000077254	-0.01007404617457719	[134]	[236]	0	hSpCas9	negative selection	10770461
77723330	77723353	1	-	28162770	SKM1	viability	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	0.1446782287779682	[218]	[427]	1	hSpCas9	negative selection	10770462
77717926	77717949	1	+	28162770	SKM1	viability	GGACTATCCTTAGCAAGAAATGG	USP33	ENSG00000077254	0.4641552658435347	[97]	[238]	4	hSpCas9	negative selection	10770463
77714767	77714790	1	-	28162770	SKM1	viability	TAATAGGAAGAGCAGCGAAGAGG	USP33	ENSG00000077254	0.04234320262042818	[38]	[70]	0	hSpCas9	negative selection	10770464
77711794	77711817	1	-	28162770	SKM1	viability	TCATACTTGCCAAATTGAGGCGG	USP33	ENSG00000077254	0.138105574854482	[54]	[106]	1	hSpCas9	negative selection	10770465
77725669	77725692	1	+	28162770	PL21	viability	GGAGGGCTTGCCGATAAACGTGG	USP33	ENSG00000077254	-0.4917380901483479	[83]	[25]	-4	hSpCas9	negative selection	10939822
77736055	77736078	1	-	28162770	PL21	viability	GAAGATGAACTTAGGGCCAGAGG	USP33	ENSG00000077254	0.7330136040620222	[187]	[135]	6	hSpCas9	negative selection	10939823
77722053	77722076	1	-	28162770	PL21	viability	AAGCATATGCTCCACAAGGGTGG	USP33	ENSG00000077254	-0.9352122384055661	[267]	[60]	-6	hSpCas9	negative selection	10939824
77741375	77741398	1	-	28162770	PL21	viability	AAATCTTTGGGCATGTCTGGAGG	USP33	ENSG00000077254	0.517879912413249	[68]	[42]	4	hSpCas9	negative selection	10939825
77739364	77739387	1	+	28162770	PL21	viability	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	-0.6145572829094522	[196]	[55]	-4	hSpCas9	negative selection	10939826
77729915	77729938	1	+	28162770	PL21	viability	GTAGTAGGCACAACAGATCCTGG	USP33	ENSG00000077254	0.44981563746809505	[433]	[257]	4	hSpCas9	negative selection	10939827
77723330	77723353	1	-	28162770	PL21	viability	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	-0.49972498104463847	[626]	[192]	-4	hSpCas9	negative selection	10939828
77717926	77717949	1	+	28162770	PL21	viability	GGACTATCCTTAGCAAGAAATGG	USP33	ENSG00000077254	-0.3068203742305628	[323]	[113]	-2	hSpCas9	negative selection	10939829
77714767	77714790	1	-	28162770	PL21	viability	TAATAGGAAGAGCAGCGAAGAGG	USP33	ENSG00000077254	1.2468328499373618	[151]	[156]	8	hSpCas9	negative selection	10939830
77711794	77711817	1	-	28162770	PL21	viability	TCATACTTGCCAAATTGAGGCGG	USP33	ENSG00000077254	-0.5822689504380529	[171]	[49]	-4	hSpCas9	negative selection	10939831
77725669	77725692	1	+	28162770	P31FUJ	viability	GGAGGGCTTGCCGATAAACGTGG	USP33	ENSG00000077254	0.4472075049397518	[92]	[148]	5	hSpCas9	negative selection	11109188
77736055	77736078	1	-	28162770	P31FUJ	viability	GAAGATGAACTTAGGGCCAGAGG	USP33	ENSG00000077254	0.46812631435510244	[226]	[368]	5	hSpCas9	negative selection	11109189
77722053	77722076	1	-	28162770	P31FUJ	viability	AAGCATATGCTCCACAAGGGTGG	USP33	ENSG00000077254	0.3595854029740386	[322]	[486]	4	hSpCas9	negative selection	11109190
77741375	77741398	1	-	28162770	P31FUJ	viability	AAATCTTTGGGCATGTCTGGAGG	USP33	ENSG00000077254	-0.02025756903427811	[62]	[72]	0	hSpCas9	negative selection	11109191
77739364	77739387	1	+	28162770	P31FUJ	viability	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	-0.2134368795474476	[147]	[149]	-2	hSpCas9	negative selection	11109192
77729915	77729938	1	+	28162770	P31FUJ	viability	GTAGTAGGCACAACAGATCCTGG	USP33	ENSG00000077254	0.13990988539094373	[440]	[570]	1	hSpCas9	negative selection	11109193
77723330	77723353	1	-	28162770	P31FUJ	viability	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	0.5470351970128353	[861]	[1479]	6	hSpCas9	negative selection	11109194
77717926	77717949	1	+	28162770	P31FUJ	viability	GGACTATCCTTAGCAAGAAATGG	USP33	ENSG00000077254	1.053398185998458	[416]	[1016]	9	hSpCas9	negative selection	11109195
77714767	77714790	1	-	28162770	P31FUJ	viability	TAATAGGAAGAGCAGCGAAGAGG	USP33	ENSG00000077254	0.010575242051405073	[233]	[276]	0	hSpCas9	negative selection	11109196
77711794	77711817	1	-	28162770	P31FUJ	viability	TCATACTTGCCAAATTGAGGCGG	USP33	ENSG00000077254	0.323831573248283	[239]	[352]	3	hSpCas9	negative selection	11109197
77725669	77725692	1	+	28162770	OCIAML5	viability	GGAGGGCTTGCCGATAAACGTGG	USP33	ENSG00000077254	0.7473954995522745	[32]	[99]	6	hSpCas9	negative selection	11278554
77736055	77736078	1	-	28162770	OCIAML5	viability	GAAGATGAACTTAGGGCCAGAGG	USP33	ENSG00000077254	0.7367075438071781	[125]	[378]	6	hSpCas9	negative selection	11278555
77722053	77722076	1	-	28162770	OCIAML5	viability	AAGCATATGCTCCACAAGGGTGG	USP33	ENSG00000077254	0.6044036474021929	[132]	[364]	5	hSpCas9	negative selection	11278556
77741375	77741398	1	-	28162770	OCIAML5	viability	AAATCTTTGGGCATGTCTGGAGG	USP33	ENSG00000077254	1.4522674640086275	[32]	[162]	9	hSpCas9	negative selection	11278557
77739364	77739387	1	+	28162770	OCIAML5	viability	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	0.15255005720637282	[155]	[312]	1	hSpCas9	negative selection	11278558
77729915	77729938	1	+	28162770	OCIAML5	viability	GTAGTAGGCACAACAGATCCTGG	USP33	ENSG00000077254	-0.13264155800692623	[330]	[544]	-1	hSpCas9	negative selection	11278559
77723330	77723353	1	-	28162770	OCIAML5	viability	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	0.44351328216093044	[430]	[1057]	4	hSpCas9	negative selection	11278560
77717926	77717949	1	+	28162770	OCIAML5	viability	GGACTATCCTTAGCAAGAAATGG	USP33	ENSG00000077254	0.023523086946059202	[350]	[643]	0	hSpCas9	negative selection	11278561
77714767	77714790	1	-	28162770	OCIAML5	viability	TAATAGGAAGAGCAGCGAAGAGG	USP33	ENSG00000077254	-0.3724570702890694	[141]	[197]	-3	hSpCas9	negative selection	11278562
77711794	77711817	1	-	28162770	OCIAML5	viability	TCATACTTGCCAAATTGAGGCGG	USP33	ENSG00000077254	0.68453290829576	[90]	[263]	6	hSpCas9	negative selection	11278563
77725669	77725692	1	+	28162770	EOL1	viability	GGAGGGCTTGCCGATAAACGTGG	USP33	ENSG00000077254	0.12704063546927774	[218]	[125]	1	hSpCas9	negative selection	11447920
77736055	77736078	1	-	28162770	EOL1	viability	GAAGATGAACTTAGGGCCAGAGG	USP33	ENSG00000077254	0.02825912109264203	[321]	[172]	0	hSpCas9	negative selection	11447921
77722053	77722076	1	-	28162770	EOL1	viability	AAGCATATGCTCCACAAGGGTGG	USP33	ENSG00000077254	1.0597303983380293	[508]	[558]	8	hSpCas9	negative selection	11447922
77741375	77741398	1	-	28162770	EOL1	viability	AAATCTTTGGGCATGTCTGGAGG	USP33	ENSG00000077254	-0.04327182268031571	[132]	[67]	0	hSpCas9	negative selection	11447923
77739364	77739387	1	+	28162770	EOL1	viability	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	0.7666681117888153	[327]	[293]	6	hSpCas9	negative selection	11447924
77729915	77729938	1	+	28162770	EOL1	viability	GTAGTAGGCACAACAGATCCTGG	USP33	ENSG00000077254	0.02432090624302674	[809]	[433]	0	hSpCas9	negative selection	11447925
77723330	77723353	1	-	28162770	EOL1	viability	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	-0.17748686260043067	[907]	[422]	-1	hSpCas9	negative selection	11447926
77717926	77717949	1	+	28162770	EOL1	viability	GGACTATCCTTAGCAAGAAATGG	USP33	ENSG00000077254	0.989480007204931	[390]	[408]	8	hSpCas9	negative selection	11447927
77714767	77714790	1	-	28162770	EOL1	viability	TAATAGGAAGAGCAGCGAAGAGG	USP33	ENSG00000077254	0.7983706654933898	[202]	[185]	7	hSpCas9	negative selection	11447928
77711794	77711817	1	-	28162770	EOL1	viability	TCATACTTGCCAAATTGAGGCGG	USP33	ENSG00000077254	0.12385657979394138	[215]	[123]	1	hSpCas9	negative selection	11447929
77725669	77725692	1	+	28162770	MOLM13	viability	GGAGGGCTTGCCGATAAACGTGG	USP33	ENSG00000077254	1.7036608326822265	[137]	[324]	9	hSpCas9	negative selection	11617286
77736055	77736078	1	-	28162770	MOLM13	viability	GAAGATGAACTTAGGGCCAGAGG	USP33	ENSG00000077254	-0.6684830601867068	[254]	[115]	-4	hSpCas9	negative selection	11617287
77722053	77722076	1	-	28162770	MOLM13	viability	AAGCATATGCTCCACAAGGGTGG	USP33	ENSG00000077254	0.5301176817199198	[362]	[378]	4	hSpCas9	negative selection	11617288
77741375	77741398	1	-	28162770	MOLM13	viability	AAATCTTTGGGCATGTCTGGAGG	USP33	ENSG00000077254	-0.7071973250135126	[69]	[30]	-4	hSpCas9	negative selection	11617289
77739364	77739387	1	+	28162770	MOLM13	viability	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	0.38542722135260576	[251]	[237]	3	hSpCas9	negative selection	11617290
77729915	77729938	1	+	28162770	MOLM13	viability	GTAGTAGGCACAACAGATCCTGG	USP33	ENSG00000077254	0.2867034189772468	[626]	[552]	2	hSpCas9	negative selection	11617291
77723330	77723353	1	-	28162770	MOLM13	viability	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	0.06728183894045547	[828]	[627]	0	hSpCas9	negative selection	11617292
77717926	77717949	1	+	28162770	MOLM13	viability	GGACTATCCTTAGCAAGAAATGG	USP33	ENSG00000077254	-0.907150049802346	[497]	[191]	-5	hSpCas9	negative selection	11617293
77714767	77714790	1	-	28162770	MOLM13	viability	TAATAGGAAGAGCAGCGAAGAGG	USP33	ENSG00000077254	0.0022258091957669812	[202]	[146]	0	hSpCas9	negative selection	11617294
77711794	77711817	1	-	28162770	MOLM13	viability	TCATACTTGCCAAATTGAGGCGG	USP33	ENSG00000077254	-1.1477699163994939	[284]	[92]	-6	hSpCas9	negative selection	11617295
77725669	77725692	1	+	28162770	HEL	viability	GGAGGGCTTGCCGATAAACGTGG	USP33	ENSG00000077254	0.7682697140842158	[120]	[131]	6	hSpCas9	negative selection	11786652
77736055	77736078	1	-	28162770	HEL	viability	GAAGATGAACTTAGGGCCAGAGG	USP33	ENSG00000077254	0.988170863793334	[206]	[262]	8	hSpCas9	negative selection	11786653
77722053	77722076	1	-	28162770	HEL	viability	AAGCATATGCTCCACAAGGGTGG	USP33	ENSG00000077254	0.3295809467407267	[368]	[296]	2	hSpCas9	negative selection	11786654
77741375	77741398	1	-	28162770	HEL	viability	AAATCTTTGGGCATGTCTGGAGG	USP33	ENSG00000077254	1.3346165366380252	[64]	[104]	9	hSpCas9	negative selection	11786655
77739364	77739387	1	+	28162770	HEL	viability	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	0.576396337171661	[266]	[254]	5	hSpCas9	negative selection	11786656
77729915	77729938	1	+	28162770	HEL	viability	GTAGTAGGCACAACAGATCCTGG	USP33	ENSG00000077254	0.5780089454547417	[546]	[522]	5	hSpCas9	negative selection	11786657
77723330	77723353	1	-	28162770	HEL	viability	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	0.505779618779757	[794]	[722]	4	hSpCas9	negative selection	11786658
77717926	77717949	1	+	28162770	HEL	viability	GGACTATCCTTAGCAAGAAATGG	USP33	ENSG00000077254	0.5563240801828838	[343]	[323]	5	hSpCas9	negative selection	11786659
77714767	77714790	1	-	28162770	HEL	viability	TAATAGGAAGAGCAGCGAAGAGG	USP33	ENSG00000077254	-1.1937624357167638	[199]	[55]	-6	hSpCas9	negative selection	11786660
77711794	77711817	1	-	28162770	HEL	viability	TCATACTTGCCAAATTGAGGCGG	USP33	ENSG00000077254	-0.2948952870392695	[248]	[129]	-2	hSpCas9	negative selection	11786661
77725669	77725692	1	+	28162770	MV411	viability	GGAGGGCTTGCCGATAAACGTGG	USP33	ENSG00000077254	0.5389003649430866	[133]	[163]	5	hSpCas9	negative selection	11956018
77736055	77736078	1	-	28162770	MV411	viability	GAAGATGAACTTAGGGCCAGAGG	USP33	ENSG00000077254	0.33624681774063137	[188]	[200]	3	hSpCas9	negative selection	11956019
77722053	77722076	1	-	28162770	MV411	viability	AAGCATATGCTCCACAAGGGTGG	USP33	ENSG00000077254	-0.17577387994176863	[294]	[219]	-1	hSpCas9	negative selection	11956020
77741375	77741398	1	-	28162770	MV411	viability	AAATCTTTGGGCATGTCTGGAGG	USP33	ENSG00000077254	0.7478665412922638	[40]	[57]	6	hSpCas9	negative selection	11956021
77739364	77739387	1	+	28162770	MV411	viability	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	0.7227755603294332	[204]	[284]	6	hSpCas9	negative selection	11956022
77729915	77729938	1	+	28162770	MV411	viability	GTAGTAGGCACAACAGATCCTGG	USP33	ENSG00000077254	0.991904766884989	[421]	[706]	8	hSpCas9	negative selection	11956023
77723330	77723353	1	-	28162770	MV411	viability	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	0.25206899951442097	[621]	[623]	2	hSpCas9	negative selection	11956024
77717926	77717949	1	+	28162770	MV411	viability	GGACTATCCTTAGCAAGAAATGG	USP33	ENSG00000077254	0.5315335721443988	[339]	[413]	5	hSpCas9	negative selection	11956025
77714767	77714790	1	-	28162770	MV411	viability	TAATAGGAAGAGCAGCGAAGAGG	USP33	ENSG00000077254	-0.19648106848319724	[184]	[135]	-1	hSpCas9	negative selection	11956026
77711794	77711817	1	-	28162770	MV411	viability	TCATACTTGCCAAATTGAGGCGG	USP33	ENSG00000077254	-0.37327497488758277	[142]	[92]	-3	hSpCas9	negative selection	11956027
77725669	77725692	1	+	28162770	MONOMAC1	viability	GGAGGGCTTGCCGATAAACGTGG	USP33	ENSG00000077254	-0.7480520158573721	[62]	[42]	-6	hSpCas9	negative selection	12125384
77736055	77736078	1	-	28162770	MONOMAC1	viability	GAAGATGAACTTAGGGCCAGAGG	USP33	ENSG00000077254	0.2269894354465448	[119]	[160]	2	hSpCas9	negative selection	12125385
77722053	77722076	1	-	28162770	MONOMAC1	viability	AAGCATATGCTCCACAAGGGTGG	USP33	ENSG00000077254	0.6072988306992565	[204]	[357]	6	hSpCas9	negative selection	12125386
77741375	77741398	1	-	28162770	MONOMAC1	viability	AAATCTTTGGGCATGTCTGGAGG	USP33	ENSG00000077254	-0.134301091711591	[44]	[46]	-1	hSpCas9	negative selection	12125387
77739364	77739387	1	+	28162770	MONOMAC1	viability	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	0.4365355978862241	[106]	[165]	4	hSpCas9	negative selection	12125388
77729915	77729938	1	+	28162770	MONOMAC1	viability	GTAGTAGGCACAACAGATCCTGG	USP33	ENSG00000077254	-0.2681199451210363	[311]	[296]	-2	hSpCas9	negative selection	12125389
77723330	77723353	1	-	28162770	MONOMAC1	viability	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	0.42153404630442215	[395]	[607]	4	hSpCas9	negative selection	12125390
77717926	77717949	1	+	28162770	MONOMAC1	viability	GGACTATCCTTAGCAAGAAATGG	USP33	ENSG00000077254	0.44515052235455266	[172]	[269]	4	hSpCas9	negative selection	12125391
77714767	77714790	1	-	28162770	MONOMAC1	viability	TAATAGGAAGAGCAGCGAAGAGG	USP33	ENSG00000077254	0.3963378934778025	[113]	[171]	4	hSpCas9	negative selection	12125392
77711794	77711817	1	-	28162770	MONOMAC1	viability	TCATACTTGCCAAATTGAGGCGG	USP33	ENSG00000077254	0.5643522210458701	[81]	[138]	5	hSpCas9	negative selection	12125393
77725669	77725692	1	+	28162770	OCIAML2	viability	GGAGGGCTTGCCGATAAACGTGG	USP33	ENSG00000077254	1.355918662048754	[15]	[226]	9	hSpCas9	negative selection	12294750
77736055	77736078	1	-	28162770	OCIAML2	viability	GAAGATGAACTTAGGGCCAGAGG	USP33	ENSG00000077254	-0.01517805751740925	[32]	[180]	0	hSpCas9	negative selection	12294751
77722053	77722076	1	-	28162770	OCIAML2	viability	AAGCATATGCTCCACAAGGGTGG	USP33	ENSG00000077254	0.08674684380709535	[43]	[258]	0	hSpCas9	negative selection	12294752
77741375	77741398	1	-	28162770	OCIAML2	viability	AAATCTTTGGGCATGTCTGGAGG	USP33	ENSG00000077254	0.04182017569462704	[16]	[96]	0	hSpCas9	negative selection	12294753
77739364	77739387	1	+	28162770	OCIAML2	viability	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	0.6368986390622839	[41]	[361]	6	hSpCas9	negative selection	12294754
77729915	77729938	1	+	28162770	OCIAML2	viability	GTAGTAGGCACAACAGATCCTGG	USP33	ENSG00000077254	0.5317726649731436	[74]	[600]	5	hSpCas9	negative selection	12294755
77723330	77723353	1	-	28162770	OCIAML2	viability	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	1.0872208298617538	[93]	[1106]	9	hSpCas9	negative selection	12294756
77717926	77717949	1	+	28162770	OCIAML2	viability	GGACTATCCTTAGCAAGAAATGG	USP33	ENSG00000077254	0.9529120062718466	[36]	[396]	8	hSpCas9	negative selection	12294757
77714767	77714790	1	-	28162770	OCIAML2	viability	TAATAGGAAGAGCAGCGAAGAGG	USP33	ENSG00000077254	-0.7950647757400983	[35]	[114]	-5	hSpCas9	negative selection	12294758
77711794	77711817	1	-	28162770	OCIAML2	viability	TCATACTTGCCAAATTGAGGCGG	USP33	ENSG00000077254	0.3565335778956232	[30]	[219]	3	hSpCas9	negative selection	12294759
77725669	77725692	1	+	28162770	OCIAML3	viability	GGAGGGCTTGCCGATAAACGTGG	USP33	ENSG00000077254	-1.263859038631832	[34]	[43]	-7	hSpCas9	negative selection	12464116
77736055	77736078	1	-	28162770	OCIAML3	viability	GAAGATGAACTTAGGGCCAGAGG	USP33	ENSG00000077254	0.5976124322174682	[43]	[200]	5	hSpCas9	negative selection	12464117
77722053	77722076	1	-	28162770	OCIAML3	viability	AAGCATATGCTCCACAAGGGTGG	USP33	ENSG00000077254	0.24249362739295743	[90]	[324]	2	hSpCas9	negative selection	12464118
77741375	77741398	1	-	28162770	OCIAML3	viability	AAATCTTTGGGCATGTCTGGAGG	USP33	ENSG00000077254	0.853451336647058	[10]	[59]	7	hSpCas9	negative selection	12464119
77739364	77739387	1	+	28162770	OCIAML3	viability	ATAACACCATACTCGAAGAGTGG	USP33	ENSG00000077254	0.1804326592607059	[56]	[194]	1	hSpCas9	negative selection	12464120
77729915	77729938	1	+	28162770	OCIAML3	viability	GTAGTAGGCACAACAGATCCTGG	USP33	ENSG00000077254	-0.24284232421170437	[126]	[323]	-2	hSpCas9	negative selection	12464121
77723330	77723353	1	-	28162770	OCIAML3	viability	GCAGTGTCTGACTTGTGACAGGG	USP33	ENSG00000077254	-0.19620467846167333	[199]	[526]	-1	hSpCas9	negative selection	12464122
77717926	77717949	1	+	28162770	OCIAML3	viability	GGACTATCCTTAGCAAGAAATGG	USP33	ENSG00000077254	0.3939195273752618	[89]	[356]	3	hSpCas9	negative selection	12464123
77714767	77714790	1	-	28162770	OCIAML3	viability	TAATAGGAAGAGCAGCGAAGAGG	USP33	ENSG00000077254	-0.4672504980382245	[48]	[106]	-4	hSpCas9	negative selection	12464124
77711794	77711817	1	-	28162770	OCIAML3	viability	TCATACTTGCCAAATTGAGGCGG	USP33	ENSG00000077254	-0.34608012688057765	[63]	[151]	-3	hSpCas9	negative selection	12464125