| 93185321 | 93185344 | 9 | - | 26627737 | DLD1 | viability | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | 0.6820463916642084 | [220] | [18,149,157] | 6 | hSpCas9 | negative selection | 843612 | 93229719 | 93229742 | 9 | + | 26627737 | DLD1 | viability | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | 0.5857605176713054 | [525] | [224,319,204] | 6 | hSpCas9 | negative selection | 843613 | 93234935 | 93234958 | 9 | + | 26627737 | DLD1 | viability | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | 0.23159601737606306 | [682] | [248,245,255] | 2 | hSpCas9 | negative selection | 843614 | 93238246 | 93238269 | 9 | - | 26627737 | DLD1 | viability | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | 0.4642480892545292 | [738] | [240,424,297] | 5 | hSpCas9 | negative selection | 843615 | 93239818 | 93239841 | 9 | + | 26627737 | DLD1 | viability | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | -1.1396541927565578 | [291] | [37,24,57] | -7 | hSpCas9 | negative selection | 843616 | 93247719 | 93247742 | 9 | - | 26627737 | DLD1 | viability | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | -0.3298689811386577 | [397] | [90,151,61] | -3 | hSpCas9 | negative selection | 843617 | 93185321 | 93185344 | 9 | - | 26627737 | GBM cells | viability after 5 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | 0.7782323924632226 | [80] | [62,85] | 9 | hSpCas9 | negative selection | 925927 | 93229719 | 93229742 | 9 | + | 26627737 | GBM cells | viability after 5 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | -0.019913121509675502 | [310] | [143,184] | 0 | hSpCas9 | negative selection | 925928 | 93234935 | 93234958 | 9 | + | 26627737 | GBM cells | viability after 5 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | -0.08191381583946838 | [298] | [172,129] | -1 | hSpCas9 | negative selection | 925929 | 93238246 | 93238269 | 9 | - | 26627737 | GBM cells | viability after 5 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | -0.07228886080687946 | [495] | [198,306] | -1 | hSpCas9 | negative selection | 925930 | 93239818 | 93239841 | 9 | + | 26627737 | GBM cells | viability after 5 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | 0.14371754364239286 | [145] | [107,64] | 2 | hSpCas9 | negative selection | 925931 | 93247719 | 93247742 | 9 | - | 26627737 | GBM cells | viability after 5 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | 0.5391837472859388 | [144] | [112,112] | 7 | hSpCas9 | negative selection | 925932 | 93185321 | 93185344 | 9 | - | 26627737 | GBM cells | viability after 13 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | 0.2248346797403089 | [80] | [84,23] | 3 | hSpCas9 | negative selection | 1008242 | 93229719 | 93229742 | 9 | + | 26627737 | GBM cells | viability after 13 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | 0.006911840715688677 | [310] | [168,169] | 0 | hSpCas9 | negative selection | 1008243 | 93234935 | 93234958 | 9 | + | 26627737 | GBM cells | viability after 13 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | 0.07874285947242665 | [298] | [215,134] | 1 | hSpCas9 | negative selection | 1008244 | 93238246 | 93238269 | 9 | - | 26627737 | GBM cells | viability after 13 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | -0.12282433787847102 | [495] | [282,217] | -1 | hSpCas9 | negative selection | 1008245 | 93239818 | 93239841 | 9 | + | 26627737 | GBM cells | viability after 13 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | 0.8429218608801676 | [145] | [183,107] | 8 | hSpCas9 | negative selection | 1008246 | 93247719 | 93247742 | 9 | - | 26627737 | GBM cells | viability after 13 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | 0.4575725656629318 | [144] | [112,103] | 6 | hSpCas9 | negative selection | 1008247 | 93185321 | 93185344 | 9 | - | 26627737 | GBM cells | viability after 21 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | 0.9557964489324242 | [80] | [76,92] | 8 | hSpCas9 | negative selection | 1090557 | 93229719 | 93229742 | 9 | + | 26627737 | GBM cells | viability after 21 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | -0.12244944118478876 | [310] | [161,148] | -1 | hSpCas9 | negative selection | 1090558 | 93234935 | 93234958 | 9 | + | 26627737 | GBM cells | viability after 21 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | 0.11165018154822753 | [298] | [186,164] | 1 | hSpCas9 | negative selection | 1090559 | 93238246 | 93238269 | 9 | - | 26627737 | GBM cells | viability after 21 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | 0.22412502129002454 | [495] | [343,287] | 2 | hSpCas9 | negative selection | 1090560 | 93239818 | 93239841 | 9 | + | 26627737 | GBM cells | viability after 21 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | 0.6510543020987555 | [145] | [134,114] | 6 | hSpCas9 | negative selection | 1090561 | 93247719 | 93247742 | 9 | - | 26627737 | GBM cells | viability after 21 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | 0.7851916383512944 | [144] | [117,151] | 7 | hSpCas9 | negative selection | 1090562 | 93185321 | 93185344 | 9 | - | 26627737 | RPE1 | viability after 9 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | 1.8824076283559814 | [145] | [178,154] | 8 | hSpCas9 | negative selection | 1172872 | 93229719 | 93229742 | 9 | + | 26627737 | RPE1 | viability after 9 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | 0.1501542051857357 | [1080] | [399,343] | 1 | hSpCas9 | negative selection | 1172873 | 93234935 | 93234958 | 9 | + | 26627737 | RPE1 | viability after 9 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | 0.15373063342317994 | [813] | [186,407] | 1 | hSpCas9 | negative selection | 1172874 | 93238246 | 93238269 | 9 | - | 26627737 | RPE1 | viability after 9 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | 0.2529144944890518 | [1736] | [492,847] | 1 | hSpCas9 | negative selection | 1172875 | 93239818 | 93239841 | 9 | + | 26627737 | RPE1 | viability after 9 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | 1.7120002412062947 | [72] | [104,35] | 8 | hSpCas9 | negative selection | 1172876 | 93247719 | 93247742 | 9 | - | 26627737 | RPE1 | viability after 9 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | 1.9873250204023694 | [223] | [212,361] | 8 | hSpCas9 | negative selection | 1172877 | 93185321 | 93185344 | 9 | - | 26627737 | RPE1 | viability after 12 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | 1.5344686826533653 | [145] | [100,126] | 8 | hSpCas9 | negative selection | 1255187 | 93229719 | 93229742 | 9 | + | 26627737 | RPE1 | viability after 12 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | 0.3880331425819847 | [1080] | [449,305] | 2 | hSpCas9 | negative selection | 1255188 | 93234935 | 93234958 | 9 | + | 26627737 | RPE1 | viability after 12 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | -0.01636021619868045 | [813] | [206,225] | 0 | hSpCas9 | negative selection | 1255189 | 93238246 | 93238269 | 9 | - | 26627737 | RPE1 | viability after 12 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | -0.11692791417686332 | [1736] | [424,435] | -1 | hSpCas9 | negative selection | 1255190 | 93239818 | 93239841 | 9 | + | 26627737 | RPE1 | viability after 12 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | 2.441576917621795 | [72] | [107,104] | 9 | hSpCas9 | negative selection | 1255191 | 93247719 | 93247742 | 9 | - | 26627737 | RPE1 | viability after 12 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | 1.9959905431570846 | [223] | [224,255] | 8 | hSpCas9 | negative selection | 1255192 | 93185321 | 93185344 | 9 | - | 26627737 | RPE1 | viability after 15 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | 0.5694945286898225 | [145] | [44,76] | 3 | hSpCas9 | negative selection | 1337502 | 93229719 | 93229742 | 9 | + | 26627737 | RPE1 | viability after 15 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | 0.15166358716123357 | [1080] | [300,376] | 1 | hSpCas9 | negative selection | 1337503 | 93234935 | 93234958 | 9 | + | 26627737 | RPE1 | viability after 15 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | 0.3233327911640681 | [813] | [281,293] | 2 | hSpCas9 | negative selection | 1337504 | 93238246 | 93238269 | 9 | - | 26627737 | RPE1 | viability after 15 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | 0.5108530306806489 | [1736] | [551,842] | 3 | hSpCas9 | negative selection | 1337505 | 93239818 | 93239841 | 9 | + | 26627737 | RPE1 | viability after 15 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | 2.7421979803310594 | [72] | [184,92] | 9 | hSpCas9 | negative selection | 1337506 | 93247719 | 93247742 | 9 | - | 26627737 | RPE1 | viability after 15 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | 1.7949225855903186 | [223] | [226,212] | 8 | hSpCas9 | negative selection | 1337507 | 93185321 | 93185344 | 9 | - | 26627737 | RPE1 | viability after 18 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | 1.5209300000157218 | [145] | [85,141] | 7 | hSpCas9 | negative selection | 1419817 | 93229719 | 93229742 | 9 | + | 26627737 | RPE1 | viability after 18 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | 0.4163736565599471 | [1080] | [296,487] | 2 | hSpCas9 | negative selection | 1419818 | 93234935 | 93234958 | 9 | + | 26627737 | RPE1 | viability after 18 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | 0.4987371839381656 | [813] | [248,375] | 3 | hSpCas9 | negative selection | 1419819 | 93238246 | 93238269 | 9 | - | 26627737 | RPE1 | viability after 18 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | 0.26567328841100246 | [1736] | [593,530] | 1 | hSpCas9 | negative selection | 1419820 | 93239818 | 93239841 | 9 | + | 26627737 | RPE1 | viability after 18 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | 2.9318951445771466 | [72] | [130,170] | 9 | hSpCas9 | negative selection | 1419821 | 93247719 | 93247742 | 9 | - | 26627737 | RPE1 | viability after 18 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | 2.331364988619827 | [223] | [179,436] | 9 | hSpCas9 | negative selection | 1419822 | 93185321 | 93185344 | 9 | - | 26627737 | HeLa | viability after 8 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | 0.6075885874092362 | [194] | [280,21,118] | 5 | hSpCas9 | negative selection | 1502132 | 93229719 | 93229742 | 9 | + | 26627737 | HeLa | viability after 8 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | 0.8604262304545477 | [584] | [692,514,244] | 7 | hSpCas9 | negative selection | 1502133 | 93234935 | 93234958 | 9 | + | 26627737 | HeLa | viability after 8 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | 0.7477518367046938 | [432] | [239,222,458] | 6 | hSpCas9 | negative selection | 1502134 | 93238246 | 93238269 | 9 | - | 26627737 | HeLa | viability after 8 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | 0.764289448406745 | [568] | [460,558,261] | 6 | hSpCas9 | negative selection | 1502135 | 93239818 | 93239841 | 9 | + | 26627737 | HeLa | viability after 8 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | 0.018749409199990796 | [225] | [154,10,141] | 0 | hSpCas9 | negative selection | 1502136 | 93247719 | 93247742 | 9 | - | 26627737 | HeLa | viability after 8 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | 2.3768765016028444 | [58] | [190,121,101] | 9 | hSpCas9 | negative selection | 1502137 | 93185321 | 93185344 | 9 | - | 26627737 | HeLa | viability after 12 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | 0.32868291486689105 | [194] | [85,83,134] | 3 | hSpCas9 | negative selection | 1584447 | 93229719 | 93229742 | 9 | + | 26627737 | HeLa | viability after 12 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | 0.6720584225255591 | [584] | [398,224,548] | 5 | hSpCas9 | negative selection | 1584448 | 93234935 | 93234958 | 9 | + | 26627737 | HeLa | viability after 12 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | 0.8634150392540985 | [432] | [480,166,349] | 6 | hSpCas9 | negative selection | 1584449 | 93238246 | 93238269 | 9 | - | 26627737 | HeLa | viability after 12 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | 0.9488023441513062 | [568] | [329,501,520] | 7 | hSpCas9 | negative selection | 1584450 | 93239818 | 93239841 | 9 | + | 26627737 | HeLa | viability after 12 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | 0.5401152925514896 | [225] | [106,46,261] | 4 | hSpCas9 | negative selection | 1584451 | 93247719 | 93247742 | 9 | - | 26627737 | HeLa | viability after 12 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | 2.361040954902517 | [58] | [274,69,40] | 9 | hSpCas9 | negative selection | 1584452 | 93185321 | 93185344 | 9 | - | 26627737 | HeLa | viability after 15 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | 0.874699844303001 | [194] | [190,136,104] | 6 | hSpCas9 | negative selection | 1666762 | 93229719 | 93229742 | 9 | + | 26627737 | HeLa | viability after 15 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | 0.9070507223188534 | [584] | [533,389,411] | 7 | hSpCas9 | negative selection | 1666763 | 93234935 | 93234958 | 9 | + | 26627737 | HeLa | viability after 15 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | 0.5867850630718876 | [432] | [151,326,320] | 5 | hSpCas9 | negative selection | 1666764 | 93238246 | 93238269 | 9 | - | 26627737 | HeLa | viability after 15 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | 0.8015772833993488 | [568] | [298,323,604] | 6 | hSpCas9 | negative selection | 1666765 | 93239818 | 93239841 | 9 | + | 26627737 | HeLa | viability after 15 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | -1.3016413737766726 | [225] | [38,34,37] | -8 | hSpCas9 | negative selection | 1666766 | 93247719 | 93247742 | 9 | - | 26627737 | HeLa | viability after 15 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | 3.2137712081532013 | [58] | [405,147,102] | 9 | hSpCas9 | negative selection | 1666767 | 93185321 | 93185344 | 9 | - | 26627737 | HeLa | viability after 18 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | 0.8984189815764445 | [194] | [133,111,104] | 6 | hSpCas9 | negative selection | 1749077 | 93229719 | 93229742 | 9 | + | 26627737 | HeLa | viability after 18 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | 0.8983206993219842 | [584] | [360,312,411] | 6 | hSpCas9 | negative selection | 1749078 | 93234935 | 93234958 | 9 | + | 26627737 | HeLa | viability after 18 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | 0.6007289171002903 | [432] | [101,276,320] | 5 | hSpCas9 | negative selection | 1749079 | 93238246 | 93238269 | 9 | - | 26627737 | HeLa | viability after 18 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | 0.7989230508462423 | [568] | [204,260,604] | 6 | hSpCas9 | negative selection | 1749080 | 93239818 | 93239841 | 9 | + | 26627737 | HeLa | viability after 18 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | -1.3656876715111952 | [225] | [22,28,37] | -8 | hSpCas9 | negative selection | 1749081 | 93247719 | 93247742 | 9 | - | 26627737 | HeLa | viability after 18 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | 3.2096010835696163 | [58] | [273,118,102] | 9 | hSpCas9 | negative selection | 1749082 | 93185321 | 93185344 | 9 | - | 26627737 | HCT116 | viability after 6 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | 1.2589006063267805 | [465] | [135,196] | 6 | hSpCas9 | negative selection | 1831392 | 93229719 | 93229742 | 9 | + | 26627737 | HCT116 | viability after 6 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | 0.21721778280011073 | [1269] | [467,101] | 1 | hSpCas9 | negative selection | 1831393 | 93234935 | 93234958 | 9 | + | 26627737 | HCT116 | viability after 6 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | 1.040095352068838 | [1226] | [444,369] | 5 | hSpCas9 | negative selection | 1831394 | 93238246 | 93238269 | 9 | - | 26627737 | HCT116 | viability after 6 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | -0.6256972600115144 | [1362] | [241,81] | -4 | hSpCas9 | negative selection | 1831395 | 93239818 | 93239841 | 9 | + | 26627737 | HCT116 | viability after 6 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | 1.4258722779892925 | [343] | [85,177] | 7 | hSpCas9 | negative selection | 1831396 | 93247719 | 93247742 | 9 | - | 26627737 | HCT116 | viability after 6 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | 1.1540653670282608 | [285] | [159,66] | 6 | hSpCas9 | negative selection | 1831397 | 93185321 | 93185344 | 9 | - | 26627737 | HCT116 | viability after 8 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | -0.25249079160931254 | [192] | [26,91,146] | -3 | hSpCas9 | negative selection | 1913707 | 93229719 | 93229742 | 9 | + | 26627737 | HCT116 | viability after 8 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | -0.26088143572009925 | [769] | [290,400,368] | -3 | hSpCas9 | negative selection | 1913708 | 93234935 | 93234958 | 9 | + | 26627737 | HCT116 | viability after 8 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | 0.9642095466518713 | [272] | [397,245,238] | 8 | hSpCas9 | negative selection | 1913709 | 93238246 | 93238269 | 9 | - | 26627737 | HCT116 | viability after 8 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | -0.03420069057266262 | [594] | [327,338,293] | 0 | hSpCas9 | negative selection | 1913710 | 93239818 | 93239841 | 9 | + | 26627737 | HCT116 | viability after 8 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | 0.02762951653188983 | [184] | [109,110,90] | 0 | hSpCas9 | negative selection | 1913711 | 93247719 | 93247742 | 9 | - | 26627737 | HCT116 | viability after 8 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | 0.8799771474585028 | [83] | [108,63,82] | 7 | hSpCas9 | negative selection | 1913712 | 93185321 | 93185344 | 9 | - | 26627737 | HCT116 | viability after 9 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | -0.3122241703042309 | [465] | [121,82] | -2 | hSpCas9 | negative selection | 1996022 | 93229719 | 93229742 | 9 | + | 26627737 | HCT116 | viability after 9 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | -0.32818171529564355 | [1269] | [268,270] | -2 | hSpCas9 | negative selection | 1996023 | 93234935 | 93234958 | 9 | + | 26627737 | HCT116 | viability after 9 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | -1.2061826028047542 | [1226] | [79,190] | -7 | hSpCas9 | negative selection | 1996024 | 93238246 | 93238269 | 9 | - | 26627737 | HCT116 | viability after 9 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | -0.22309458074903687 | [1362] | [451,200] | -1 | hSpCas9 | negative selection | 1996025 | 93239818 | 93239841 | 9 | + | 26627737 | HCT116 | viability after 9 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | 0.042823037450925194 | [343] | [102,87] | 0 | hSpCas9 | negative selection | 1996026 | 93247719 | 93247742 | 9 | - | 26627737 | HCT116 | viability after 9 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | 1.1409131105119332 | [285] | [216,129] | 7 | hSpCas9 | negative selection | 1996027 | 93185321 | 93185344 | 9 | - | 26627737 | HCT116 | viability after 12 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | -0.41823924037873095 | [192] | [59,112,56] | -4 | hSpCas9 | negative selection | 2078337 | 93229719 | 93229742 | 9 | + | 26627737 | HCT116 | viability after 12 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | -0.635909783232226 | [769] | [239,341,202] | -6 | hSpCas9 | negative selection | 2078338 | 93234935 | 93234958 | 9 | + | 26627737 | HCT116 | viability after 12 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | 0.8195505665096291 | [272] | [341,219,188] | 7 | hSpCas9 | negative selection | 2078339 | 93238246 | 93238269 | 9 | - | 26627737 | HCT116 | viability after 12 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | 0.26308853202845817 | [594] | [263,354,515] | 2 | hSpCas9 | negative selection | 2078340 | 93239818 | 93239841 | 9 | + | 26627737 | HCT116 | viability after 12 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | -0.15333447896646213 | [184] | [84,67,108] | -1 | hSpCas9 | negative selection | 2078341 | 93247719 | 93247742 | 9 | - | 26627737 | HCT116 | viability after 12 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | 1.8520836026530414 | [83] | [156,104,214] | 9 | hSpCas9 | negative selection | 2078342 | 93185321 | 93185344 | 9 | - | 26627737 | HCT116 | viability after 15 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | 0.12003731069741785 | [192] | [71,206,76] | 1 | hSpCas9 | negative selection | 2160652 | 93229719 | 93229742 | 9 | + | 26627737 | HCT116 | viability after 15 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | -0.055823063633067216 | [769] | [438,419,418] | 0 | hSpCas9 | negative selection | 2160653 | 93234935 | 93234958 | 9 | + | 26627737 | HCT116 | viability after 15 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | 1.080606731786798 | [272] | [388,219,391] | 8 | hSpCas9 | negative selection | 2160654 | 93238246 | 93238269 | 9 | - | 26627737 | HCT116 | viability after 15 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | 0.28424155617187075 | [594] | [230,426,565] | 3 | hSpCas9 | negative selection | 2160655 | 93239818 | 93239841 | 9 | + | 26627737 | HCT116 | viability after 15 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | 0.26156705927362056 | [184] | [137,85,158] | 2 | hSpCas9 | negative selection | 2160656 | 93247719 | 93247742 | 9 | - | 26627737 | HCT116 | viability after 15 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | 1.002082973324991 | [83] | [103,109,76] | 8 | hSpCas9 | negative selection | 2160657 | 93185321 | 93185344 | 9 | - | 26627737 | HCT116 | viability after 18 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | 0.25546149655343947 | [192] | [65,96,174] | 2 | hSpCas9 | negative selection | 2242967 | 93229719 | 93229742 | 9 | + | 26627737 | HCT116 | viability after 18 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | -0.5926140770179431 | [769] | [220,270,246] | -5 | hSpCas9 | negative selection | 2242968 | 93234935 | 93234958 | 9 | + | 26627737 | HCT116 | viability after 18 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | 1.3388370705137849 | [272] | [399,336,260] | 8 | hSpCas9 | negative selection | 2242969 | 93238246 | 93238269 | 9 | - | 26627737 | HCT116 | viability after 18 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | -0.28291535873572027 | [594] | [68,281,360] | -3 | hSpCas9 | negative selection | 2242970 | 93239818 | 93239841 | 9 | + | 26627737 | HCT116 | viability after 18 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | -0.27087211138968725 | [184] | [69,61,91] | -2 | hSpCas9 | negative selection | 2242971 | 93247719 | 93247742 | 9 | - | 26627737 | HCT116 | viability after 18 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | 1.7853849617464854 | [83] | [196,81,144] | 9 | hSpCas9 | negative selection | 2242972 | 93184915 | 93184938 | 9 | + | 24336569 | HL60 | viability | CCTTGGCCCACAGAGATGGACGG | WNK2 | ENSG00000165238 | 0.0715227603557318 | [732] | [1629] | 0 | hSpCas9 | negative selection | 2306725 | 93184921 | 93184944 | 9 | + | 24336569 | HL60 | viability | CCCACAGAGATGGACGGCGATGG | WNK2 | ENSG00000165238 | 1.9643681230185228 | [394] | [3261] | 9 | hSpCas9 | negative selection | 2306726 | 93184960 | 93184983 | 9 | - | 24336569 | HL60 | viability | CCGGGCTCCATCAGCGTGCCGGG | WNK2 | ENSG00000165238 | 0.03984219559323725 | [455] | [991] | 0 | hSpCas9 | negative selection | 2306727 | 93184966 | 93184989 | 9 | + | 24336569 | HL60 | viability | ACGCTGATGGAGCCCGGGCGCGG | WNK2 | ENSG00000165238 | 0.3471251242887245 | [648] | [1746] | 3 | hSpCas9 | negative selection | 2306728 | 93184996 | 93185019 | 9 | - | 24336569 | HL60 | viability | CGAGGCTCCGCCATGCCCGCGGG | WNK2 | ENSG00000165238 | -0.28455596600640787 | [197] | [343] | -2 | hSpCas9 | negative selection | 2306729 | 93185004 | 93185027 | 9 | + | 24336569 | HL60 | viability | CATGGCGGAGCCTCGGGCGAAGG | WNK2 | ENSG00000165238 | 0.46317200020535726 | [652] | [1904] | 4 | hSpCas9 | negative selection | 2306730 | 93185012 | 93185035 | 9 | + | 24336569 | HL60 | viability | AGCCTCGGGCGAAGGCGGCGCGG | WNK2 | ENSG00000165238 | 0.7495749440995713 | [560] | [1995] | 6 | hSpCas9 | negative selection | 2306731 | 93185042 | 93185065 | 9 | - | 24336569 | HL60 | viability | GCTGCGCCGCAGAAAGCGCTGGG | WNK2 | ENSG00000165238 | 0.8940738419291923 | [341] | [1344] | 7 | hSpCas9 | negative selection | 2306732 | 93185055 | 93185078 | 9 | + | 24336569 | HL60 | viability | GCGGCGCAGCGTGGTAGAGTCGG | WNK2 | ENSG00000165238 | -0.010904733838027703 | [807] | [1696] | 0 | hSpCas9 | negative selection | 2306733 | 93185061 | 93185084 | 9 | + | 24336569 | HL60 | viability | CAGCGTGGTAGAGTCGGACCAGG | WNK2 | ENSG00000165238 | -0.16392626082086925 | [836] | [1580] | -1 | hSpCas9 | negative selection | 2306734 | 93184915 | 93184938 | 9 | + | 24336569 | KBM7 | viability | CCTTGGCCCACAGAGATGGACGG | WNK2 | ENSG00000165238 | 0.7112278404092749 | [824] | [3683] | 6 | hSpCas9 | negative selection | 2373902 | 93184921 | 93184944 | 9 | + | 24336569 | KBM7 | viability | CCCACAGAGATGGACGGCGATGG | WNK2 | ENSG00000165238 | -0.3853727734544783 | [521] | [1089] | -3 | hSpCas9 | negative selection | 2373903 | 93184960 | 93184983 | 9 | - | 24336569 | KBM7 | viability | CCGGGCTCCATCAGCGTGCCGGG | WNK2 | ENSG00000165238 | 1.071988886201268 | [172] | [991] | 8 | hSpCas9 | negative selection | 2373904 | 93184966 | 93184989 | 9 | + | 24336569 | KBM7 | viability | ACGCTGATGGAGCCCGGGCGCGG | WNK2 | ENSG00000165238 | 0.8858732335341235 | [398] | [2010] | 7 | hSpCas9 | negative selection | 2373905 | 93184996 | 93185019 | 9 | - | 24336569 | KBM7 | viability | CGAGGCTCCGCCATGCCCGCGGG | WNK2 | ENSG00000165238 | 0.9900415880970865 | [102] | [557] | 8 | hSpCas9 | negative selection | 2373906 | 93185004 | 93185027 | 9 | + | 24336569 | KBM7 | viability | CATGGCGGAGCCTCGGGCGAAGG | WNK2 | ENSG00000165238 | 0.6317527099296839 | [313] | [1326] | 6 | hSpCas9 | negative selection | 2373907 | 93185012 | 93185035 | 9 | + | 24336569 | KBM7 | viability | AGCCTCGGGCGAAGGCGGCGCGG | WNK2 | ENSG00000165238 | 0.18744101072701036 | [641] | [1993] | 1 | hSpCas9 | negative selection | 2373908 | 93185042 | 93185065 | 9 | - | 24336569 | KBM7 | viability | GCTGCGCCGCAGAAAGCGCTGGG | WNK2 | ENSG00000165238 | -0.5472240369903101 | [471] | [880] | -4 | hSpCas9 | negative selection | 2373909 | 93185055 | 93185078 | 9 | + | 24336569 | KBM7 | viability | GCGGCGCAGCGTGGTAGAGTCGG | WNK2 | ENSG00000165238 | 0.053358376135608454 | [488] | [1383] | 0 | hSpCas9 | negative selection | 2373910 | 93185061 | 93185084 | 9 | + | 24336569 | KBM7 | viability | CAGCGTGGTAGAGTCGGACCAGG | WNK2 | ENSG00000165238 | 1.0451767127269558 | [567] | [3196] | 8 | hSpCas9 | negative selection | 2373911 | 93191932 | 93191955 | 9 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CAGAAGAATCGCTTGAACCCAGG | WNK2 | ENSG00000165238 | 0.6947743245442068 | [118,16] | [8,38] | 3 | dCas9-VP64 | positive selection | 2469086 | 93191932 | 93191955 | 9 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CAGAAGAATCGCTTGAACCCAGG | WNK2 | ENSG00000165238 | -1.217410828372933 | [137,230] | [25,24] | -9 | dCas9-VP64 | positive selection | 2564341 | 93185266 | 93185289 | 9 | + | 27661255 | K562 | viability | GACGCCGGCCCCGAGCCCGTGGG | WNK2 | ENSG00000165238 | 0.15542485081145718 | [968,1497] | [1204,989] | 5 | dCas9-KRAB | negative selection | 5522922 | 93185565 | 93185588 | 9 | + | 27661255 | K562 | viability | GCTGGACACGGAGACCTGGGTGG | WNK2 | ENSG00000165238 | 0.08100052332393304 | [557,601] | [544,441] | 3 | dCas9-KRAB | negative selection | 5522923 | 93185321 | 93185344 | 9 | - | 27661255 | K562 | viability | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | -0.01581499963378763 | [557,624] | [440,487] | 0 | dCas9-KRAB | negative selection | 5522924 | 93185641 | 93185664 | 9 | - | 27661255 | K562 | viability | GCACTCGCGGACAGACCCTGCGG | WNK2 | ENSG00000165238 | 0.2130737129786074 | [709,907] | [856,650] | 7 | dCas9-KRAB | negative selection | 5522925 | 93185321 | 93185344 | 9 | - | 27869803 | HPAFII | viability after 27 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | -0.5765894790268782 | [130] | [43,47,NaN] | -4 | hSpCas9 | negative selection | 9606717 | 93229719 | 93229742 | 9 | + | 27869803 | HPAFII | viability after 27 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | 0.21320546927979733 | [648] | [364,420,NaN] | 1 | hSpCas9 | negative selection | 9606718 | 93234935 | 93234958 | 9 | + | 27869803 | HPAFII | viability after 27 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | -0.07323439740585125 | [321] | [143,174,NaN] | 0 | hSpCas9 | negative selection | 9606719 | 93238246 | 93238269 | 9 | - | 27869803 | HPAFII | viability after 27 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | 0.6814125876243992 | [418] | [331,370,NaN] | 5 | hSpCas9 | negative selection | 9606720 | 93239818 | 93239841 | 9 | + | 27869803 | HPAFII | viability after 27 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | 0.9063063352582021 | [117] | [40,178,NaN] | 7 | hSpCas9 | negative selection | 9606721 | 93247719 | 93247742 | 9 | - | 27869803 | HPAFII | viability after 27 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | -0.40069573298385686 | [175] | [80,60,NaN] | -3 | hSpCas9 | negative selection | 9606722 | 93185321 | 93185344 | 9 | - | 27869803 | HPAFII | viability after 15 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | -0.14813067649608547 | [130] | [139,118,NaN] | -2 | hSpCas9 | negative selection | 9689166 | 93229719 | 93229742 | 9 | + | 27869803 | HPAFII | viability after 15 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | -0.06995424970995834 | [648] | [1039,430,NaN] | 0 | hSpCas9 | negative selection | 9689167 | 93234935 | 93234958 | 9 | + | 27869803 | HPAFII | viability after 15 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | 0.32046828738282934 | [321] | [515,379,NaN] | 3 | hSpCas9 | negative selection | 9689168 | 93238246 | 93238269 | 9 | - | 27869803 | HPAFII | viability after 15 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | 0.6554469833162487 | [418] | [757,678,NaN] | 7 | hSpCas9 | negative selection | 9689169 | 93239818 | 93239841 | 9 | + | 27869803 | HPAFII | viability after 15 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | 0.08622780132015473 | [117] | [88,162,NaN] | 1 | hSpCas9 | negative selection | 9689170 | 93247719 | 93247742 | 9 | - | 27869803 | HPAFII | viability after 15 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | -0.20301246359042857 | [175] | [233,120,NaN] | -2 | hSpCas9 | negative selection | 9689171 | 93185321 | 93185344 | 9 | - | 27869803 | ASPC1 | viability after 36 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | 0.3138587703412745 | [515] | [39,211,359] | 3 | hSpCas9 | negative selection | 9771615 | 93229719 | 93229742 | 9 | + | 27869803 | ASPC1 | viability after 36 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | -0.4443123784268723 | [1377] | [418,404,262] | -4 | hSpCas9 | negative selection | 9771616 | 93234935 | 93234958 | 9 | + | 27869803 | ASPC1 | viability after 36 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | 0.5126102469447891 | [887] | [661,414,304] | 5 | hSpCas9 | negative selection | 9771617 | 93238246 | 93238269 | 9 | - | 27869803 | ASPC1 | viability after 36 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | 1.0448809280048454 | [1048] | [1029,791,525] | 8 | hSpCas9 | negative selection | 9771618 | 93239818 | 93239841 | 9 | + | 27869803 | ASPC1 | viability after 36 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | 0.7487149632236574 | [324] | [184,373,46] | 7 | hSpCas9 | negative selection | 9771619 | 93247719 | 93247742 | 9 | - | 27869803 | ASPC1 | viability after 36 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | 0.7899995337625981 | [451] | [33,86,584] | 7 | hSpCas9 | negative selection | 9771620 | 93185321 | 93185344 | 9 | - | 27869803 | PATU8988S | viability after 35 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | -0.44440019259169616 | [347] | [102,102,NaN] | -4 | hSpCas9 | negative selection | 9854064 | 93229719 | 93229742 | 9 | + | 27869803 | PATU8988S | viability after 35 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | 0.4000221623982647 | [1190] | [608,656,NaN] | 4 | hSpCas9 | negative selection | 9854065 | 93234935 | 93234958 | 9 | + | 27869803 | PATU8988S | viability after 35 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | 0.1320922114562203 | [753] | [459,204,NaN] | 1 | hSpCas9 | negative selection | 9854066 | 93238246 | 93238269 | 9 | - | 27869803 | PATU8988S | viability after 35 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | 1.1365663871784022 | [954] | [901,788,NaN] | 9 | hSpCas9 | negative selection | 9854067 | 93239818 | 93239841 | 9 | + | 27869803 | PATU8988S | viability after 35 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | -0.4371128371737274 | [369] | [138,80,NaN] | -4 | hSpCas9 | negative selection | 9854068 | 93247719 | 93247742 | 9 | - | 27869803 | PATU8988S | viability after 35 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | -0.13611022242901094 | [306] | [117,106,NaN] | -1 | hSpCas9 | negative selection | 9854069 | 93185321 | 93185344 | 9 | - | 27869803 | PATU8988S | viability after 31 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | -0.37241286638205684 | [347] | [71,151,NaN] | -4 | hSpCas9 | negative selection | 9936513 | 93229719 | 93229742 | 9 | + | 27869803 | PATU8988S | viability after 31 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | 0.6139160008856948 | [1190] | [706,751,NaN] | 7 | hSpCas9 | negative selection | 9936514 | 93234935 | 93234958 | 9 | + | 27869803 | PATU8988S | viability after 31 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | 0.19601250759049005 | [753] | [372,307,NaN] | 2 | hSpCas9 | negative selection | 9936515 | 93238246 | 93238269 | 9 | - | 27869803 | PATU8988S | viability after 31 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | 0.9375537615502727 | [954] | [621,865,NaN] | 9 | hSpCas9 | negative selection | 9936516 | 93239818 | 93239841 | 9 | + | 27869803 | PATU8988S | viability after 31 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | -0.24138247702831706 | [369] | [148,93,NaN] | -3 | hSpCas9 | negative selection | 9936517 | 93247719 | 93247742 | 9 | - | 27869803 | PATU8988S | viability after 31 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | -0.07269164792699401 | [306] | [111,121,NaN] | -1 | hSpCas9 | negative selection | 9936518 | 93185321 | 93185344 | 9 | - | 27869803 | HPAFII | viability after 35 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | -0.053028328282830994 | [130] | [30,100,NaN] | 0 | hSpCas9 | negative selection | 10018962 | 93229719 | 93229742 | 9 | + | 27869803 | HPAFII | viability after 35 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | 0.10255252933153858 | [648] | [221,499,NaN] | 0 | hSpCas9 | negative selection | 10018963 | 93234935 | 93234958 | 9 | + | 27869803 | HPAFII | viability after 35 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | 0.43076776573031733 | [321] | [151,295,NaN] | 2 | hSpCas9 | negative selection | 10018964 | 93238246 | 93238269 | 9 | - | 27869803 | HPAFII | viability after 35 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | 1.0164748014480205 | [418] | [287,587,NaN] | 7 | hSpCas9 | negative selection | 10018965 | 93239818 | 93239841 | 9 | + | 27869803 | HPAFII | viability after 35 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | 0.5682425786131347 | [117] | [57,122,NaN] | 3 | hSpCas9 | negative selection | 10018966 | 93247719 | 93247742 | 9 | - | 27869803 | HPAFII | viability after 35 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | -0.42966950408799076 | [175] | [12,125,NaN] | -3 | hSpCas9 | negative selection | 10018967 | 93185321 | 93185344 | 9 | - | 27869803 | HPAFII | viability after 31 days | GGCAGGCGCGGTTTCGACAGCGG | WNK2 | ENSG00000165238 | -1.2276873687763927 | [130] | [28,33,NaN] | -6 | hSpCas9 | negative selection | 10101411 | 93229719 | 93229742 | 9 | + | 27869803 | HPAFII | viability after 31 days | GCGGCAGCGGTTCAAGGAAGAGG | WNK2 | ENSG00000165238 | 0.3230109394492007 | [648] | [424,488,NaN] | 2 | hSpCas9 | negative selection | 10101412 | 93234935 | 93234958 | 9 | + | 27869803 | HPAFII | viability after 31 days | TGCGGCCCAGATCTACCGCAAGG | WNK2 | ENSG00000165238 | 0.4251449023822376 | [321] | [189,299,NaN] | 3 | hSpCas9 | negative selection | 10101413 | 93238246 | 93238269 | 9 | - | 27869803 | HPAFII | viability after 31 days | ATCGTGCACTTTCTCAAAGCTGG | WNK2 | ENSG00000165238 | 0.8066120275889258 | [418] | [283,549,NaN] | 6 | hSpCas9 | negative selection | 10101414 | 93239818 | 93239841 | 9 | + | 27869803 | HPAFII | viability after 31 days | GAGCTCGCGGAGGAGGACCACGG | WNK2 | ENSG00000165238 | 0.031355361314266306 | [117] | [26,111,NaN] | 0 | hSpCas9 | negative selection | 10101415 | 93247719 | 93247742 | 9 | - | 27869803 | HPAFII | viability after 31 days | CCTGTGCATGGTAGGTCACCTGG | WNK2 | ENSG00000165238 | -0.5636672895545783 | [175] | [62,70,NaN] | -4 | hSpCas9 | negative selection | 10101416 | 93185535 | 93185558 | 9 | - | 28162770 | P31FUJ | viability | AGACCGTCTTGAAGGAACCGCGG | WNK2 | ENSG00000165238 | 0.2786981343657564 | [375] | [535] | 3 | hSpCas9 | negative selection | 10265517 | 93234901 | 93234924 | 9 | - | 28162770 | P31FUJ | viability | CGAGTAGGGGTACTCCGAGGTGG | WNK2 | ENSG00000165238 | 0.262234616929685 | [170] | [240] | 3 | hSpCas9 | negative selection | 10265518 | 93239808 | 93239831 | 9 | + | 28162770 | P31FUJ | viability | CGTGAGGGTGGAGCTCGCGGAGG | WNK2 | ENSG00000165238 | 0.17840851532395186 | [754] | [1003] | 1 | hSpCas9 | negative selection | 10265519 | 93263955 | 93263978 | 9 | + | 28162770 | P31FUJ | viability | GGAGACGCACAACCACAAGATGG | WNK2 | ENSG00000165238 | 0.5180110362418329 | [393] | [662] | 6 | hSpCas9 | negative selection | 10265520 | 93289488 | 93289511 | 9 | + | 28162770 | P31FUJ | viability | GGGCGACAGAGACTTCACCCTGG | WNK2 | ENSG00000165238 | 0.022039155950893896 | [1500] | [1790] | 0 | hSpCas9 | negative selection | 10265521 | 93297913 | 93297936 | 9 | - | 28162770 | P31FUJ | viability | GCAGTGGCTTGCCCAGGCGGCGG | WNK2 | ENSG00000165238 | 0.5243826564957859 | [580] | [981] | 6 | hSpCas9 | negative selection | 10265522 | 93308458 | 93308481 | 9 | + | 28162770 | P31FUJ | viability | CGAGTGGACGAGCAAGACGGTGG | WNK2 | ENSG00000165238 | 0.13884074531511903 | [1408] | [1822] | 1 | hSpCas9 | negative selection | 10265523 | 93185089 | 93185112 | 9 | - | 28162770 | P31FUJ | viability | TCGGCTGCCTCCAAGCCCGGCGG | WNK2 | ENSG00000165238 | 0.24303857392666517 | [1811] | [2519] | 2 | hSpCas9 | negative selection | 10265524 | 93185439 | 93185462 | 9 | + | 28162770 | P31FUJ | viability | GGACGAGCCCGAAGAGGAGGAGG | WNK2 | ENSG00000165238 | -0.5760069589321558 | [443] | [349] | -5 | hSpCas9 | negative selection | 10265525 | 93185489 | 93185512 | 9 | - | 28162770 | P31FUJ | viability | GAAGCGGCCGTCCAGAGAGGTGG | WNK2 | ENSG00000165238 | -0.2517075696665301 | [1228] | [1212] | -2 | hSpCas9 | negative selection | 10265526 | 93185535 | 93185558 | 9 | - | 28162770 | TF1 | viability | AGACCGTCTTGAAGGAACCGCGG | WNK2 | ENSG00000165238 | NaN | [NaN] | [37] | 1 | hSpCas9 | negative selection | 10434883 | 93234901 | 93234924 | 9 | - | 28162770 | TF1 | viability | CGAGTAGGGGTACTCCGAGGTGG | WNK2 | ENSG00000165238 | NaN | [NaN] | [31] | 1 | hSpCas9 | negative selection | 10434884 | 93239808 | 93239831 | 9 | + | 28162770 | TF1 | viability | CGTGAGGGTGGAGCTCGCGGAGG | WNK2 | ENSG00000165238 | NaN | [NaN] | [105] | 1 | hSpCas9 | negative selection | 10434885 | 93263955 | 93263978 | 9 | + | 28162770 | TF1 | viability | GGAGACGCACAACCACAAGATGG | WNK2 | ENSG00000165238 | NaN | [NaN] | [32] | 1 | hSpCas9 | negative selection | 10434886 | 93289488 | 93289511 | 9 | + | 28162770 | TF1 | viability | GGGCGACAGAGACTTCACCCTGG | WNK2 | ENSG00000165238 | NaN | [NaN] | [280] | 1 | hSpCas9 | negative selection | 10434887 | 93297913 | 93297936 | 9 | - | 28162770 | TF1 | viability | GCAGTGGCTTGCCCAGGCGGCGG | WNK2 | ENSG00000165238 | NaN | [NaN] | [126] | 1 | hSpCas9 | negative selection | 10434888 | 93308458 | 93308481 | 9 | + | 28162770 | TF1 | viability | CGAGTGGACGAGCAAGACGGTGG | WNK2 | ENSG00000165238 | NaN | [NaN] | [234] | 1 | hSpCas9 | negative selection | 10434889 | 93185089 | 93185112 | 9 | - | 28162770 | TF1 | viability | TCGGCTGCCTCCAAGCCCGGCGG | WNK2 | ENSG00000165238 | NaN | [NaN] | [304] | 1 | hSpCas9 | negative selection | 10434890 | 93185439 | 93185462 | 9 | + | 28162770 | TF1 | viability | GGACGAGCCCGAAGAGGAGGAGG | WNK2 | ENSG00000165238 | NaN | [NaN] | [154] | 1 | hSpCas9 | negative selection | 10434891 | 93185489 | 93185512 | 9 | - | 28162770 | TF1 | viability | GAAGCGGCCGTCCAGAGAGGTGG | WNK2 | ENSG00000165238 | NaN | [NaN] | [135] | 1 | hSpCas9 | negative selection | 10434892 | 93185535 | 93185558 | 9 | - | 28162770 | SKM1 | viability | AGACCGTCTTGAAGGAACCGCGG | WNK2 | ENSG00000165238 | 0.008073300535682226 | [35] | [63] | 0 | hSpCas9 | negative selection | 10604249 | 93234901 | 93234924 | 9 | - | 28162770 | SKM1 | viability | CGAGTAGGGGTACTCCGAGGTGG | WNK2 | ENSG00000165238 | -0.27451390271951226 | [12] | [18] | -2 | hSpCas9 | negative selection | 10604250 | 93239808 | 93239831 | 9 | + | 28162770 | SKM1 | viability | CGTGAGGGTGGAGCTCGCGGAGG | WNK2 | ENSG00000165238 | 1.3750351490375483 | [40] | [187] | 9 | hSpCas9 | negative selection | 10604251 | 93263955 | 93263978 | 9 | + | 28162770 | SKM1 | viability | GGAGACGCACAACCACAAGATGG | WNK2 | ENSG00000165238 | -0.5682451057762223 | [25] | [30] | -4 | hSpCas9 | negative selection | 10604252 | 93289488 | 93289511 | 9 | + | 28162770 | SKM1 | viability | GGGCGACAGAGACTTCACCCTGG | WNK2 | ENSG00000165238 | 0.3895024071717061 | [75] | [175] | 4 | hSpCas9 | negative selection | 10604253 | 93297913 | 93297936 | 9 | - | 28162770 | SKM1 | viability | GCAGTGGCTTGCCCAGGCGGCGG | WNK2 | ENSG00000165238 | 1.0993884672816279 | [32] | [124] | 8 | hSpCas9 | negative selection | 10604254 | 93308458 | 93308481 | 9 | + | 28162770 | SKM1 | viability | CGAGTGGACGAGCAAGACGGTGG | WNK2 | ENSG00000165238 | -0.00360850451195327 | [92] | [163] | 0 | hSpCas9 | negative selection | 10604255 | 93185089 | 93185112 | 9 | - | 28162770 | SKM1 | viability | TCGGCTGCCTCCAAGCCCGGCGG | WNK2 | ENSG00000165238 | 0.156193931659646 | [99] | [196] | 1 | hSpCas9 | negative selection | 10604256 | 93185439 | 93185462 | 9 | + | 28162770 | SKM1 | viability | GGACGAGCCCGAAGAGGAGGAGG | WNK2 | ENSG00000165238 | 0.7085130186767742 | [26] | [77] | 6 | hSpCas9 | negative selection | 10604257 | 93185489 | 93185512 | 9 | - | 28162770 | SKM1 | viability | GAAGCGGCCGTCCAGAGAGGTGG | WNK2 | ENSG00000165238 | 0.16765635775653542 | [69] | [138] | 1 | hSpCas9 | negative selection | 10604258 | 93185535 | 93185558 | 9 | - | 28162770 | SKM1 | viability | AGACCGTCTTGAAGGAACCGCGG | WNK2 | ENSG00000165238 | 0.008073300535682226 | [35] | [63] | 0 | hSpCas9 | negative selection | 10773615 | 93234901 | 93234924 | 9 | - | 28162770 | SKM1 | viability | CGAGTAGGGGTACTCCGAGGTGG | WNK2 | ENSG00000165238 | -0.27451390271951226 | [12] | [18] | -2 | hSpCas9 | negative selection | 10773616 | 93239808 | 93239831 | 9 | + | 28162770 | SKM1 | viability | CGTGAGGGTGGAGCTCGCGGAGG | WNK2 | ENSG00000165238 | 1.3750351490375483 | [40] | [187] | 9 | hSpCas9 | negative selection | 10773617 | 93263955 | 93263978 | 9 | + | 28162770 | SKM1 | viability | GGAGACGCACAACCACAAGATGG | WNK2 | ENSG00000165238 | -0.5682451057762223 | [25] | [30] | -4 | hSpCas9 | negative selection | 10773618 | 93289488 | 93289511 | 9 | + | 28162770 | SKM1 | viability | GGGCGACAGAGACTTCACCCTGG | WNK2 | ENSG00000165238 | 0.3895024071717061 | [75] | [175] | 4 | hSpCas9 | negative selection | 10773619 | 93297913 | 93297936 | 9 | - | 28162770 | SKM1 | viability | GCAGTGGCTTGCCCAGGCGGCGG | WNK2 | ENSG00000165238 | 1.0993884672816279 | [32] | [124] | 8 | hSpCas9 | negative selection | 10773620 | 93308458 | 93308481 | 9 | + | 28162770 | SKM1 | viability | CGAGTGGACGAGCAAGACGGTGG | WNK2 | ENSG00000165238 | -0.00360850451195327 | [92] | [163] | 0 | hSpCas9 | negative selection | 10773621 | 93185089 | 93185112 | 9 | - | 28162770 | SKM1 | viability | TCGGCTGCCTCCAAGCCCGGCGG | WNK2 | ENSG00000165238 | 0.156193931659646 | [99] | [196] | 1 | hSpCas9 | negative selection | 10773622 | 93185439 | 93185462 | 9 | + | 28162770 | SKM1 | viability | GGACGAGCCCGAAGAGGAGGAGG | WNK2 | ENSG00000165238 | 0.7085130186767742 | [26] | [77] | 6 | hSpCas9 | negative selection | 10773623 | 93185489 | 93185512 | 9 | - | 28162770 | SKM1 | viability | GAAGCGGCCGTCCAGAGAGGTGG | WNK2 | ENSG00000165238 | 0.16765635775653542 | [69] | [138] | 1 | hSpCas9 | negative selection | 10773624 | 93185535 | 93185558 | 9 | - | 28162770 | PL21 | viability | AGACCGTCTTGAAGGAACCGCGG | WNK2 | ENSG00000165238 | 0.7595670231033388 | [132] | [97] | 6 | hSpCas9 | negative selection | 10942981 | 93234901 | 93234924 | 9 | - | 28162770 | PL21 | viability | CGAGTAGGGGTACTCCGAGGTGG | WNK2 | ENSG00000165238 | -1.244645228183576 | [48] | [8] | -7 | hSpCas9 | negative selection | 10942982 | 93239808 | 93239831 | 9 | + | 28162770 | PL21 | viability | CGTGAGGGTGGAGCTCGCGGAGG | WNK2 | ENSG00000165238 | -0.5021798368699949 | [191] | [58] | -4 | hSpCas9 | negative selection | 10942983 | 93263955 | 93263978 | 9 | + | 28162770 | PL21 | viability | GGAGACGCACAACCACAAGATGG | WNK2 | ENSG00000165238 | -2.372750053931261 | [118] | [9] | -8 | hSpCas9 | negative selection | 10942984 | 93289488 | 93289511 | 9 | + | 28162770 | PL21 | viability | GGGCGACAGAGACTTCACCCTGG | WNK2 | ENSG00000165238 | -1.3527107010780832 | [310] | [52] | -7 | hSpCas9 | negative selection | 10942985 | 93297913 | 93297936 | 9 | - | 28162770 | PL21 | viability | GCAGTGGCTTGCCCAGGCGGCGG | WNK2 | ENSG00000165238 | 0.28379754353622966 | [133] | [70] | 2 | hSpCas9 | negative selection | 10942986 | 93308458 | 93308481 | 9 | + | 28162770 | PL21 | viability | CGAGTGGACGAGCAAGACGGTGG | WNK2 | ENSG00000165238 | 0.4312899593033279 | [304] | [178] | 4 | hSpCas9 | negative selection | 10942987 | 93185089 | 93185112 | 9 | - | 28162770 | PL21 | viability | TCGGCTGCCTCCAAGCCCGGCGG | WNK2 | ENSG00000165238 | 0.5110025454137288 | [444] | [275] | 4 | hSpCas9 | negative selection | 10942988 | 93185439 | 93185462 | 9 | + | 28162770 | PL21 | viability | GGACGAGCCCGAAGAGGAGGAGG | WNK2 | ENSG00000165238 | -0.5853558736045447 | [130] | [37] | -4 | hSpCas9 | negative selection | 10942989 | 93185489 | 93185512 | 9 | - | 28162770 | PL21 | viability | GAAGCGGCCGTCCAGAGAGGTGG | WNK2 | ENSG00000165238 | 0.003742401685816743 | [274] | [119] | 0 | hSpCas9 | negative selection | 10942990 | 93185535 | 93185558 | 9 | - | 28162770 | P31FUJ | viability | AGACCGTCTTGAAGGAACCGCGG | WNK2 | ENSG00000165238 | 0.2786981343657564 | [375] | [535] | 3 | hSpCas9 | negative selection | 11112347 | 93234901 | 93234924 | 9 | - | 28162770 | P31FUJ | viability | CGAGTAGGGGTACTCCGAGGTGG | WNK2 | ENSG00000165238 | 0.262234616929685 | [170] | [240] | 3 | hSpCas9 | negative selection | 11112348 | 93239808 | 93239831 | 9 | + | 28162770 | P31FUJ | viability | CGTGAGGGTGGAGCTCGCGGAGG | WNK2 | ENSG00000165238 | 0.17840851532395186 | [754] | [1003] | 1 | hSpCas9 | negative selection | 11112349 | 93263955 | 93263978 | 9 | + | 28162770 | P31FUJ | viability | GGAGACGCACAACCACAAGATGG | WNK2 | ENSG00000165238 | 0.5180110362418329 | [393] | [662] | 6 | hSpCas9 | negative selection | 11112350 | 93289488 | 93289511 | 9 | + | 28162770 | P31FUJ | viability | GGGCGACAGAGACTTCACCCTGG | WNK2 | ENSG00000165238 | 0.022039155950893896 | [1500] | [1790] | 0 | hSpCas9 | negative selection | 11112351 | 93297913 | 93297936 | 9 | - | 28162770 | P31FUJ | viability | GCAGTGGCTTGCCCAGGCGGCGG | WNK2 | ENSG00000165238 | 0.5243826564957859 | [580] | [981] | 6 | hSpCas9 | negative selection | 11112352 | 93308458 | 93308481 | 9 | + | 28162770 | P31FUJ | viability | CGAGTGGACGAGCAAGACGGTGG | WNK2 | ENSG00000165238 | 0.13884074531511903 | [1408] | [1822] | 1 | hSpCas9 | negative selection | 11112353 | 93185089 | 93185112 | 9 | - | 28162770 | P31FUJ | viability | TCGGCTGCCTCCAAGCCCGGCGG | WNK2 | ENSG00000165238 | 0.24303857392666517 | [1811] | [2519] | 2 | hSpCas9 | negative selection | 11112354 | 93185439 | 93185462 | 9 | + | 28162770 | P31FUJ | viability | GGACGAGCCCGAAGAGGAGGAGG | WNK2 | ENSG00000165238 | -0.5760069589321558 | [443] | [349] | -5 | hSpCas9 | negative selection | 11112355 | 93185489 | 93185512 | 9 | - | 28162770 | P31FUJ | viability | GAAGCGGCCGTCCAGAGAGGTGG | WNK2 | ENSG00000165238 | -0.2517075696665301 | [1228] | [1212] | -2 | hSpCas9 | negative selection | 11112356 | 93185535 | 93185558 | 9 | - | 28162770 | OCIAML5 | viability | AGACCGTCTTGAAGGAACCGCGG | WNK2 | ENSG00000165238 | 1.6804285099630234 | [27] | [161] | 9 | hSpCas9 | negative selection | 11281713 | 93234901 | 93234924 | 9 | - | 28162770 | OCIAML5 | viability | CGAGTAGGGGTACTCCGAGGTGG | WNK2 | ENSG00000165238 | -0.5996794092297117 | [67] | [80] | -4 | hSpCas9 | negative selection | 11281714 | 93239808 | 93239831 | 9 | + | 28162770 | OCIAML5 | viability | CGTGAGGGTGGAGCTCGCGGAGG | WNK2 | ENSG00000165238 | 1.8946469998537714 | [58] | [395] | 9 | hSpCas9 | negative selection | 11281715 | 93263955 | 93263978 | 9 | + | 28162770 | OCIAML5 | viability | GGAGACGCACAACCACAAGATGG | WNK2 | ENSG00000165238 | -0.14511354576423052 | [67] | [110] | -1 | hSpCas9 | negative selection | 11281716 | 93289488 | 93289511 | 9 | + | 28162770 | OCIAML5 | viability | GGGCGACAGAGACTTCACCCTGG | WNK2 | ENSG00000165238 | -0.15091105263831817 | [154] | [251] | -1 | hSpCas9 | negative selection | 11281717 | 93297913 | 93297936 | 9 | - | 28162770 | OCIAML5 | viability | GCAGTGGCTTGCCCAGGCGGCGG | WNK2 | ENSG00000165238 | -0.48528424019237426 | [75] | [97] | -3 | hSpCas9 | negative selection | 11281718 | 93308458 | 93308481 | 9 | + | 28162770 | OCIAML5 | viability | CGAGTGGACGAGCAAGACGGTGG | WNK2 | ENSG00000165238 | 0.03929216913217892 | [192] | [357] | 0 | hSpCas9 | negative selection | 11281719 | 93185089 | 93185112 | 9 | - | 28162770 | OCIAML5 | viability | TCGGCTGCCTCCAAGCCCGGCGG | WNK2 | ENSG00000165238 | 0.8279784757108346 | [136] | [438] | 7 | hSpCas9 | negative selection | 11281720 | 93185439 | 93185462 | 9 | + | 28162770 | OCIAML5 | viability | GGACGAGCCCGAAGAGGAGGAGG | WNK2 | ENSG00000165238 | -0.947223803904337 | [93] | [87] | -5 | hSpCas9 | negative selection | 11281721 | 93185489 | 93185512 | 9 | - | 28162770 | OCIAML5 | viability | GAAGCGGCCGTCCAGAGAGGTGG | WNK2 | ENSG00000165238 | -0.8809214335361821 | [201] | [197] | -5 | hSpCas9 | negative selection | 11281722 | 93185535 | 93185558 | 9 | - | 28162770 | EOL1 | viability | AGACCGTCTTGAAGGAACCGCGG | WNK2 | ENSG00000165238 | -1.3973803233168278 | [124] | [24] | -7 | hSpCas9 | negative selection | 11451079 | 93234901 | 93234924 | 9 | - | 28162770 | EOL1 | viability | CGAGTAGGGGTACTCCGAGGTGG | WNK2 | ENSG00000165238 | -0.02100444440708893 | [51] | [26] | 0 | hSpCas9 | negative selection | 11451080 | 93239808 | 93239831 | 9 | + | 28162770 | EOL1 | viability | CGTGAGGGTGGAGCTCGCGGAGG | WNK2 | ENSG00000165238 | 0.6830211832773712 | [252] | [213] | 6 | hSpCas9 | negative selection | 11451081 | 93263955 | 93263978 | 9 | + | 28162770 | EOL1 | viability | GGAGACGCACAACCACAAGATGG | WNK2 | ENSG00000165238 | 0.9924518360723381 | [82] | [86] | 8 | hSpCas9 | negative selection | 11451082 | 93289488 | 93289511 | 9 | + | 28162770 | EOL1 | viability | GGGCGACAGAGACTTCACCCTGG | WNK2 | ENSG00000165238 | -0.27836564182568835 | [563] | [244] | -2 | hSpCas9 | negative selection | 11451083 | 93297913 | 93297936 | 9 | - | 28162770 | EOL1 | viability | GCAGTGGCTTGCCCAGGCGGCGG | WNK2 | ENSG00000165238 | 0.6585660816864038 | [195] | [162] | 6 | hSpCas9 | negative selection | 11451084 | 93308458 | 93308481 | 9 | + | 28162770 | EOL1 | viability | CGAGTGGACGAGCAAGACGGTGG | WNK2 | ENSG00000165238 | 0.798481467309111 | [489] | [448] | 7 | hSpCas9 | negative selection | 11451085 | 93185089 | 93185112 | 9 | - | 28162770 | EOL1 | viability | TCGGCTGCCTCCAAGCCCGGCGG | WNK2 | ENSG00000165238 | 0.8352804334734474 | [549] | [516] | 7 | hSpCas9 | negative selection | 11451086 | 93185439 | 93185462 | 9 | + | 28162770 | EOL1 | viability | GGACGAGCCCGAAGAGGAGGAGG | WNK2 | ENSG00000165238 | -1.4553859267523932 | [202] | [38] | -7 | hSpCas9 | negative selection | 11451087 | 93185489 | 93185512 | 9 | - | 28162770 | EOL1 | viability | GAAGCGGCCGTCCAGAGAGGTGG | WNK2 | ENSG00000165238 | -0.6530540241993674 | [390] | [130] | -5 | hSpCas9 | negative selection | 11451088 | 93185535 | 93185558 | 9 | - | 28162770 | MOLM13 | viability | AGACCGTCTTGAAGGAACCGCGG | WNK2 | ENSG00000165238 | 0.2584360159156289 | [147] | [127] | 1 | hSpCas9 | negative selection | 11620445 | 93234901 | 93234924 | 9 | - | 28162770 | MOLM13 | viability | CGAGTAGGGGTACTCCGAGGTGG | WNK2 | ENSG00000165238 | -3.373412872436363 | [42] | [2] | -8 | hSpCas9 | negative selection | 11620446 | 93239808 | 93239831 | 9 | + | 28162770 | MOLM13 | viability | CGTGAGGGTGGAGCTCGCGGAGG | WNK2 | ENSG00000165238 | 0.5026547997052553 | [163] | [167] | 4 | hSpCas9 | negative selection | 11620447 | 93263955 | 93263978 | 9 | + | 28162770 | MOLM13 | viability | GGAGACGCACAACCACAAGATGG | WNK2 | ENSG00000165238 | 0.6108473353866217 | [143] | [158] | 4 | hSpCas9 | negative selection | 11620448 | 93289488 | 93289511 | 9 | + | 28162770 | MOLM13 | viability | GGGCGACAGAGACTTCACCCTGG | WNK2 | ENSG00000165238 | 0.4001845224061887 | [348] | [332] | 3 | hSpCas9 | negative selection | 11620449 | 93297913 | 93297936 | 9 | - | 28162770 | MOLM13 | viability | GCAGTGGCTTGCCCAGGCGGCGG | WNK2 | ENSG00000165238 | 0.16164290888948613 | [182] | [147] | 1 | hSpCas9 | negative selection | 11620450 | 93308458 | 93308481 | 9 | + | 28162770 | MOLM13 | viability | CGAGTGGACGAGCAAGACGGTGG | WNK2 | ENSG00000165238 | 0.9801707428663475 | [440] | [628] | 7 | hSpCas9 | negative selection | 11620451 | 93185089 | 93185112 | 9 | - | 28162770 | MOLM13 | viability | TCGGCTGCCTCCAAGCCCGGCGG | WNK2 | ENSG00000165238 | -0.04583239259367189 | [483] | [338] | 0 | hSpCas9 | negative selection | 11620452 | 93185439 | 93185462 | 9 | + | 28162770 | MOLM13 | viability | GGACGAGCCCGAAGAGGAGGAGG | WNK2 | ENSG00000165238 | -0.8677136502398599 | [158] | [62] | -5 | hSpCas9 | negative selection | 11620453 | 93185489 | 93185512 | 9 | - | 28162770 | MOLM13 | viability | GAAGCGGCCGTCCAGAGAGGTGG | WNK2 | ENSG00000165238 | -1.0952467567233988 | [327] | [110] | -5 | hSpCas9 | negative selection | 11620454 | 93185535 | 93185558 | 9 | - | 28162770 | HEL | viability | AGACCGTCTTGAAGGAACCGCGG | WNK2 | ENSG00000165238 | 0.007735648779605309 | [131] | [84] | 0 | hSpCas9 | negative selection | 11789811 | 93234901 | 93234924 | 9 | - | 28162770 | HEL | viability | CGAGTAGGGGTACTCCGAGGTGG | WNK2 | ENSG00000165238 | 0.3101634929134862 | [33] | [26] | 2 | hSpCas9 | negative selection | 11789812 | 93239808 | 93239831 | 9 | + | 28162770 | HEL | viability | CGTGAGGGTGGAGCTCGCGGAGG | WNK2 | ENSG00000165238 | -0.9249456772889639 | [165] | [55] | -5 | hSpCas9 | negative selection | 11789813 | 93263955 | 93263978 | 9 | + | 28162770 | HEL | viability | GGAGACGCACAACCACAAGATGG | WNK2 | ENSG00000165238 | 0.3048691932439729 | [90] | [71] | 2 | hSpCas9 | negative selection | 11789814 | 93289488 | 93289511 | 9 | + | 28162770 | HEL | viability | GGGCGACAGAGACTTCACCCTGG | WNK2 | ENSG00000165238 | 0.26566918292053343 | [299] | [230] | 2 | hSpCas9 | negative selection | 11789815 | 93297913 | 93297936 | 9 | - | 28162770 | HEL | viability | GCAGTGGCTTGCCCAGGCGGCGG | WNK2 | ENSG00000165238 | 0.580811082857155 | [118] | [113] | 5 | hSpCas9 | negative selection | 11789816 | 93308458 | 93308481 | 9 | + | 28162770 | HEL | viability | CGAGTGGACGAGCAAGACGGTGG | WNK2 | ENSG00000165238 | 0.3854801646707219 | [348] | [291] | 3 | hSpCas9 | negative selection | 11789817 | 93185089 | 93185112 | 9 | - | 28162770 | HEL | viability | TCGGCTGCCTCCAAGCCCGGCGG | WNK2 | ENSG00000165238 | -0.5196916328950312 | [431] | [192] | -4 | hSpCas9 | negative selection | 11789818 | 93185439 | 93185462 | 9 | + | 28162770 | HEL | viability | GGACGAGCCCGAAGAGGAGGAGG | WNK2 | ENSG00000165238 | -1.2529245081849076 | [159] | [42] | -6 | hSpCas9 | negative selection | 11789819 | 93185489 | 93185512 | 9 | - | 28162770 | HEL | viability | GAAGCGGCCGTCCAGAGAGGTGG | WNK2 | ENSG00000165238 | -1.0219508611915336 | [278] | [87] | -6 | hSpCas9 | negative selection | 11789820 | 93185535 | 93185558 | 9 | - | 28162770 | MV411 | viability | AGACCGTCTTGAAGGAACCGCGG | WNK2 | ENSG00000165238 | 0.0028151820628617985 | [108] | [91] | 0 | hSpCas9 | negative selection | 11959177 | 93234901 | 93234924 | 9 | - | 28162770 | MV411 | viability | CGAGTAGGGGTACTCCGAGGTGG | WNK2 | ENSG00000165238 | -2.307151300894862 | [46] | [7] | -8 | hSpCas9 | negative selection | 11959178 | 93239808 | 93239831 | 9 | + | 28162770 | MV411 | viability | CGTGAGGGTGGAGCTCGCGGAGG | WNK2 | ENSG00000165238 | 1.976032739963101 | [120] | [400] | 9 | hSpCas9 | negative selection | 11959179 | 93263955 | 93263978 | 9 | + | 28162770 | MV411 | viability | GGAGACGCACAACCACAAGATGG | WNK2 | ENSG00000165238 | 0.9370974301706247 | [61] | [99] | 8 | hSpCas9 | negative selection | 11959180 | 93289488 | 93289511 | 9 | + | 28162770 | MV411 | viability | GGGCGACAGAGACTTCACCCTGG | WNK2 | ENSG00000165238 | -0.34714936882678116 | [375] | [248] | -3 | hSpCas9 | negative selection | 11959181 | 93297913 | 93297936 | 9 | - | 28162770 | MV411 | viability | GCAGTGGCTTGCCCAGGCGGCGG | WNK2 | ENSG00000165238 | 0.33624681774063114 | [125] | [133] | 3 | hSpCas9 | negative selection | 11959182 | 93308458 | 93308481 | 9 | + | 28162770 | MV411 | viability | CGAGTGGACGAGCAAGACGGTGG | WNK2 | ENSG00000165238 | 0.9834280215317371 | [295] | [492] | 8 | hSpCas9 | negative selection | 11959183 | 93185089 | 93185112 | 9 | - | 28162770 | MV411 | viability | TCGGCTGCCTCCAAGCCCGGCGG | WNK2 | ENSG00000165238 | 0.7023677771851319 | [320] | [439] | 6 | hSpCas9 | negative selection | 11959184 | 93185439 | 93185462 | 9 | + | 28162770 | MV411 | viability | GGACGAGCCCGAAGAGGAGGAGG | WNK2 | ENSG00000165238 | -0.34428231611368965 | [106] | [70] | -3 | hSpCas9 | negative selection | 11959185 | 93185489 | 93185512 | 9 | - | 28162770 | MV411 | viability | GAAGCGGCCGTCCAGAGAGGTGG | WNK2 | ENSG00000165238 | -0.7284768306929115 | [296] | [150] | -5 | hSpCas9 | negative selection | 11959186 | 93185535 | 93185558 | 9 | - | 28162770 | MONOMAC1 | viability | AGACCGTCTTGAAGGAACCGCGG | WNK2 | ENSG00000165238 | 0.3623905615544649 | [75] | [111] | 3 | hSpCas9 | negative selection | 12128543 | 93234901 | 93234924 | 9 | - | 28162770 | MONOMAC1 | viability | CGAGTAGGGGTACTCCGAGGTGG | WNK2 | ENSG00000165238 | -0.1095740058092145 | [31] | [33] | -1 | hSpCas9 | negative selection | 12128544 | 93239808 | 93239831 | 9 | + | 28162770 | MONOMAC1 | viability | CGTGAGGGTGGAGCTCGCGGAGG | WNK2 | ENSG00000165238 | -0.37760909270137466 | [118] | [104] | -3 | hSpCas9 | negative selection | 12128545 | 93263955 | 93263978 | 9 | + | 28162770 | MONOMAC1 | viability | GGAGACGCACAACCACAAGATGG | WNK2 | ENSG00000165238 | -0.09750117350863907 | [55] | [59] | -1 | hSpCas9 | negative selection | 12128546 | 93289488 | 93289511 | 9 | + | 28162770 | MONOMAC1 | viability | GGGCGACAGAGACTTCACCCTGG | WNK2 | ENSG00000165238 | 0.7499818612542744 | [207] | [400] | 7 | hSpCas9 | negative selection | 12128547 | 93297913 | 93297936 | 9 | - | 28162770 | MONOMAC1 | viability | GCAGTGGCTTGCCCAGGCGGCGG | WNK2 | ENSG00000165238 | -0.6432930769491176 | [108] | [79] | -5 | hSpCas9 | negative selection | 12128548 | 93308458 | 93308481 | 9 | + | 28162770 | MONOMAC1 | viability | CGAGTGGACGAGCAAGACGGTGG | WNK2 | ENSG00000165238 | 0.21409619776337407 | [184] | [245] | 2 | hSpCas9 | negative selection | 12128549 | 93185089 | 93185112 | 9 | - | 28162770 | MONOMAC1 | viability | TCGGCTGCCTCCAAGCCCGGCGG | WNK2 | ENSG00000165238 | 0.15457527207765653 | [278] | [355] | 1 | hSpCas9 | negative selection | 12128550 | 93185439 | 93185462 | 9 | + | 28162770 | MONOMAC1 | viability | GGACGAGCCCGAAGAGGAGGAGG | WNK2 | ENSG00000165238 | 0.1474086843892362 | [88] | [112] | 1 | hSpCas9 | negative selection | 12128551 | 93185489 | 93185512 | 9 | - | 28162770 | MONOMAC1 | viability | GAAGCGGCCGTCCAGAGAGGTGG | WNK2 | ENSG00000165238 | -0.3268047220298834 | [185] | [169] | -3 | hSpCas9 | negative selection | 12128552 | 93185535 | 93185558 | 9 | - | 28162770 | OCIAML2 | viability | AGACCGTCTTGAAGGAACCGCGG | WNK2 | ENSG00000165238 | -0.2182426636078758 | [16] | [80] | -2 | hSpCas9 | negative selection | 12297909 | 93234901 | 93234924 | 9 | - | 28162770 | OCIAML2 | viability | CGAGTAGGGGTACTCCGAGGTGG | WNK2 | ENSG00000165238 | 0.9118398115802517 | [6] | [72] | 8 | hSpCas9 | negative selection | 12297910 | 93239808 | 93239831 | 9 | + | 28162770 | OCIAML2 | viability | CGTGAGGGTGGAGCTCGCGGAGG | WNK2 | ENSG00000165238 | -0.2963788983970587 | [36] | [166] | -2 | hSpCas9 | negative selection | 12297911 | 93263955 | 93263978 | 9 | + | 28162770 | OCIAML2 | viability | GGAGACGCACAACCACAAGATGG | WNK2 | ENSG00000165238 | 0.22980989289893095 | [11] | [77] | 2 | hSpCas9 | negative selection | 12297912 | 93289488 | 93289511 | 9 | + | 28162770 | OCIAML2 | viability | GGGCGACAGAGACTTCACCCTGG | WNK2 | ENSG00000165238 | 0.0819111977866176 | [59] | [351] | 0 | hSpCas9 | negative selection | 12297913 | 93297913 | 93297936 | 9 | - | 28162770 | OCIAML2 | viability | GCAGTGGCTTGCCCAGGCGGCGG | WNK2 | ENSG00000165238 | 0.585638394404584 | [21] | [182] | 6 | hSpCas9 | negative selection | 12297914 | 93308458 | 93308481 | 9 | + | 28162770 | OCIAML2 | viability | CGAGTGGACGAGCAAGACGGTGG | WNK2 | ENSG00000165238 | -0.11448601501688571 | [74] | [383] | -1 | hSpCas9 | negative selection | 12297915 | 93185089 | 93185112 | 9 | - | 28162770 | OCIAML2 | viability | TCGGCTGCCTCCAAGCCCGGCGG | WNK2 | ENSG00000165238 | 0.7158542680735605 | [76] | [700] | 7 | hSpCas9 | negative selection | 12297916 | 93185439 | 93185462 | 9 | + | 28162770 | OCIAML2 | viability | GGACGAGCCCGAAGAGGAGGAGG | WNK2 | ENSG00000165238 | -1.011198206604864 | [35] | [98] | -6 | hSpCas9 | negative selection | 12297917 | 93185489 | 93185512 | 9 | - | 28162770 | OCIAML2 | viability | GAAGCGGCCGTCCAGAGAGGTGG | WNK2 | ENSG00000165238 | -0.612648830114589 | [47] | [173] | -4 | hSpCas9 | negative selection | 12297918 | 93185535 | 93185558 | 9 | - | 28162770 | OCIAML3 | viability | AGACCGTCTTGAAGGAACCGCGG | WNK2 | ENSG00000165238 | -1.3309732344903695 | [24] | [29] | -7 | hSpCas9 | negative selection | 12467275 | 93234901 | 93234924 | 9 | - | 28162770 | OCIAML3 | viability | CGAGTAGGGGTACTCCGAGGTGG | WNK2 | ENSG00000165238 | -1.6554081849883067 | [23] | [22] | -8 | hSpCas9 | negative selection | 12467276 | 93239808 | 93239831 | 9 | + | 28162770 | OCIAML3 | viability | CGTGAGGGTGGAGCTCGCGGAGG | WNK2 | ENSG00000165238 | -0.6517231381804505 | [50] | [97] | -5 | hSpCas9 | negative selection | 12467277 | 93263955 | 93263978 | 9 | + | 28162770 | OCIAML3 | viability | GGAGACGCACAACCACAAGATGG | WNK2 | ENSG00000165238 | -0.6529013293777319 | [24] | [47] | -5 | hSpCas9 | negative selection | 12467278 | 93289488 | 93289511 | 9 | + | 28162770 | OCIAML3 | viability | GGGCGACAGAGACTTCACCCTGG | WNK2 | ENSG00000165238 | 0.018331299328298134 | [86] | [265] | 0 | hSpCas9 | negative selection | 12467279 | 93297913 | 93297936 | 9 | - | 28162770 | OCIAML3 | viability | GCAGTGGCTTGCCCAGGCGGCGG | WNK2 | ENSG00000165238 | 0.34089733145395207 | [33] | [129] | 3 | hSpCas9 | negative selection | 12467280 | 93308458 | 93308481 | 9 | + | 28162770 | OCIAML3 | viability | CGAGTGGACGAGCAAGACGGTGG | WNK2 | ENSG00000165238 | 0.24249362739295732 | [83] | [299] | 2 | hSpCas9 | negative selection | 12467281 | 93185089 | 93185112 | 9 | - | 28162770 | OCIAML3 | viability | TCGGCTGCCTCCAAGCCCGGCGG | WNK2 | ENSG00000165238 | -0.2211983764346167 | [116] | [302] | -2 | hSpCas9 | negative selection | 12467282 | 93185439 | 93185462 | 9 | + | 28162770 | OCIAML3 | viability | GGACGAGCCCGAAGAGGAGGAGG | WNK2 | ENSG00000165238 | -1.0980501456617517 | [38] | [54] | -7 | hSpCas9 | negative selection | 12467283 | 93185489 | 93185512 | 9 | - | 28162770 | OCIAML3 | viability | GAAGCGGCCGTCCAGAGAGGTGG | WNK2 | ENSG00000165238 | -0.8021158356543634 | [66] | [115] | -5 | hSpCas9 | negative selection | 12467284 |