| GR00002-A | 39127 | FBgn0053696 | CG33696 | DRSC08992 | 1.550089134 | none | | no | | Lipid storage | COPI complex is a regulator of lipid homeostasis. | Beller et al. | 2008 | 19067489 | Cell line | Kc167 | Nuclear to lipid droplet cross-sectional area | Fluorescence | np | Genome-wide | dsRNA | B-score | > 2 OR < -1.7 | Additional information about a secondary screen with non-overlaping dsRNAs | GR00002-A | 39127 | FBgn0053696 | CG33696 | DRSC08992 | 1.507627071 | none | | no | | Lipid storage | COPI complex is a regulator of lipid homeostasis. | Beller et al. | 2008 | 19067489 | Cell line | Kc167 | Nuclear to lipid droplet cross-sectional area | Fluorescence | np | Genome-wide | dsRNA | B-score | > 2 OR < -1.7 | Additional information about a secondary screen with non-overlaping dsRNAs | GR00002-A | 39127 | FBgn0053696 | CG33696 | DRSC10224 | 0.718051409 | none | | no | | Lipid storage | COPI complex is a regulator of lipid homeostasis. | Beller et al. | 2008 | 19067489 | Cell line | Kc167 | Nuclear to lipid droplet cross-sectional area | Fluorescence | np | Genome-wide | dsRNA | B-score | > 2 OR < -1.7 | Additional information about a secondary screen with non-overlaping dsRNAs | GR00002-A | 39127 | FBgn0053696 | CG33696 | DRSC10224 | 1.197105476 | none | | no | | Lipid storage | COPI complex is a regulator of lipid homeostasis. | Beller et al. | 2008 | 19067489 | Cell line | Kc167 | Nuclear to lipid droplet cross-sectional area | Fluorescence | np | Genome-wide | dsRNA | B-score | > 2 OR < -1.7 | Additional information about a secondary screen with non-overlaping dsRNAs | GR00012-A-1 | 39127 | CG16726 | CG16726 | np | np | Increased viability with doxorubicin | | yes | | Caspase activation in apoptosis (1) - combinatorial effect with doxorubicin | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Genome-wide | dsRNA | Z-score | Complex criteria | | GR00012-A-2 | 39127 | CG16726 | CG16726 | np | np | none | | yes | | Caspase activation in apoptosis (2) - combinatorial effect with doxorubicin | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Caspase 3/7 activity | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39127 | CG12284, CG16726 | diap1, CG16726 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00014-A | 39127 | | CG33696 | DRSC08992 | strong | Decreased Flag-Mad nuclear accumulation | | no | | Dpp pathway regulation | Msk is required for nuclear import of TGF-{beta}/BMP-activated Smads. | Xu et al. | 2007 | 17785517 | Cell line | S2R+ | Flag-Mad protein expression and subcellular location | Fluorescence | rp | Genome-wide | dsRNA | Visual inspection | np | | GR00031-A-1 | 39127 | | | HFA10224 | 0.5 | none | | yes | | Cell growth and viability (1) | Genome-wide RNAi analysis of growth and viability in Drosophila cells. | Boutros et al. | 2004 | 14764878 | Cell line | Kc167 | Cell number and viability | Luminescence | Custom-made (HFA) | Genome-wide | dsRNA | Z-score | > | | GR00031-A-1 | 39127 | | | HFA08992 | 0.9 | none | | yes | | Cell growth and viability (1) | Genome-wide RNAi analysis of growth and viability in Drosophila cells. | Boutros et al. | 2004 | 14764878 | Cell line | Kc167 | Cell number and viability | Luminescence | Custom-made (HFA) | Genome-wide | dsRNA | Z-score | > | | GR00031-A-2 | 39127 | | | HFA08992 | -0.2 | none | | no | | Cell growth and viability (2) | Genome-wide RNAi analysis of growth and viability in Drosophila cells. | Boutros et al. | 2004 | 14764878 | Cell line | S2R+ | Cell number and viability | Luminescence | Custom-made (HFA) | Genome-wide | dsRNA | Z-score | > | | GR00031-A-2 | 39127 | | | HFA10224 | -0.8 | none | | no | | Cell growth and viability (2) | Genome-wide RNAi analysis of growth and viability in Drosophila cells. | Boutros et al. | 2004 | 14764878 | Cell line | S2R+ | Cell number and viability | Luminescence | Custom-made (HFA) | Genome-wide | dsRNA | Z-score | > | | GR00134-A-1 | 39127 | CG33696 | CG33696 | 45652 | np | none | | no | | Muscle morphogenesis and function (1) | Systematic genetic analysis of muscle morphogenesis and function in Drosophila. | Schnorrer et al. | 2010 | 20220848 | Tissue | Mef2-GAL4 | Posture, locomotion, flight and viability | Visual inspection | np | Genome-wide | UAS-IR construct | rp | S19 > 0.5 | | GR00134-A-1 | 39127 | CG33696 | CG33696 | 23222 | np | none | | no | | Muscle morphogenesis and function (1) | Systematic genetic analysis of muscle morphogenesis and function in Drosophila. | Schnorrer et al. | 2010 | 20220848 | Tissue | Mef2-GAL4 | Posture, locomotion, flight and viability | Visual inspection | np | Genome-wide | UAS-IR construct | rp | S19 > 0.5 | | GR00134-A-1 | 39127 | CG33696 | CG33696 | 23223 | np | none | | no | | Muscle morphogenesis and function (1) | Systematic genetic analysis of muscle morphogenesis and function in Drosophila. | Schnorrer et al. | 2010 | 20220848 | Tissue | Mef2-GAL4 | Posture, locomotion, flight and viability | Visual inspection | np | Genome-wide | UAS-IR construct | rp | S19 > 0.5 | | GR00135-A-1 | 39127 | CG32047 | CG33696 | 45652 | 0 | Lethal | | yes | | Heat nociception (1) | A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. | Neely et al. | 2010 | 21074052 | Organism | elav-GAL4 | Noxious heat avoidance and viability | Fly count | np | Genome-wide | UAS-IR construct | Z-score | > 1.65 | Additional information about secondary screens (geotactic, phototaxis, and temperature sensitivity) | GR00135-A-1 | 39127 | CG16726 | CG33696 | 23222 | -0.85 | none | | yes | | Heat nociception (1) | A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. | Neely et al. | 2010 | 21074052 | Organism | elav-GAL4 | Noxious heat avoidance and viability | Fly count | np | Genome-wide | UAS-IR construct | Z-score | > 1.65 | Additional information about secondary screens (geotactic, phototaxis, and temperature sensitivity) | GR00135-A-1 | 39127 | CG16726 | CG33696 | 23223 | 0.85 | none | | yes | | Heat nociception (1) | A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. | Neely et al. | 2010 | 21074052 | Organism | elav-GAL4 | Noxious heat avoidance and viability | Fly count | np | Genome-wide | UAS-IR construct | Z-score | > 1.65 | Additional information about secondary screens (geotactic, phototaxis, and temperature sensitivity) | GR00144-A-4 | 39127 | CG33696 | | 45652 | sp | Gain of bristles, notum malformation death, lateral inhibition | | yes | partially lethal | Notch pathway regulation (4) | Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. | Mummery-Widmer et al. | 2009 | 19363474 | Tissue | pnr-GAL4 | External sensory organ morphology and viability | Visual inspection | np | Genome-wide | UAS-IR construct | Phenotype strength | np | | GR00144-A-4 | 39127 | CG33696 | | 23222 | 0 | none | | yes | not lethal | Notch pathway regulation (4) | Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. | Mummery-Widmer et al. | 2009 | 19363474 | Tissue | pnr-GAL4 | External sensory organ morphology and viability | Visual inspection | np | Genome-wide | UAS-IR construct | Phenotype strength | np | | GR00144-A-4 | 39127 | CG33696 | | 23223 | 0 | none | | yes | not lethal | Notch pathway regulation (4) | Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. | Mummery-Widmer et al. | 2009 | 19363474 | Tissue | pnr-GAL4 | External sensory organ morphology and viability | Visual inspection | np | Genome-wide | UAS-IR construct | Phenotype strength | np | | GR00144-A-5 | 39127 | CG33696 | | 45652 | np | Bent up (spoon-shaped) wing | | no | | Notch pathway regulation (5) | Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. | Mummery-Widmer et al. | 2009 | 19363474 | Tissue | MS1096-GAL4 | Wing morphology and viability | Visual inspection | np | Selected genes | UAS-IR construct | Visual inspection | np | | GR00152-A | 39127 | CG33696 | CG33696 | np | -0.93373 | none | | no | without Notch stimulation | Notch induced transcription | Modifiers of notch transcriptional activity identified by genome-wide RNAi. | Mourikis et al. | 2010 | 20959007 | Cell line | Kc167 | Notch pathway reporter | Luminescence | np | Genome-wide | dsRNA | Z-score | < -2 OR > 2 (con-luc) OR < -1.8 OR > 1.8 (m3-luc) | Additional information about secondary screens | GR00152-A | 39127 | CG33696 | CG33696 | np | -0.3973 | none | | no | N(delta)ecn Notch stimulation; m3-luc normalization | Notch induced transcription | Modifiers of notch transcriptional activity identified by genome-wide RNAi. | Mourikis et al. | 2010 | 20959007 | Cell line | Kc167 | Notch pathway reporter | Luminescence | np | Genome-wide | dsRNA | Z-score | < -2 OR > 2 (con-luc) OR < -1.8 OR > 1.8 (m3-luc) | Additional information about secondary screens | GR00152-A | 39127 | CG33696 | CG33696 | np | -3.2794 | Downregulation of Notch pathway after Notch stimulation | | no | N(delta)ecn Notch stimulation; con-luc normalization | Notch induced transcription | Modifiers of notch transcriptional activity identified by genome-wide RNAi. | Mourikis et al. | 2010 | 20959007 | Cell line | Kc167 | Notch pathway reporter | Luminescence | np | Genome-wide | dsRNA | Z-score | < -2 OR > 2 (con-luc) OR < -1.8 OR > 1.8 (m3-luc) | Additional information about secondary screens | GR00218-S | 39127 | CG16726 | | AMB25336 | -0.59 | none | | no | | Hippo pathway regulation | Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila | Wehr et al. | 2013 | 23263283 | Cell line | S2R+ | Hippo pathway reporter | Luminescence | np | Genome-wide | dsRNA | Z-score | > 3 OR < -3 | Author-submitted data. Primary screen | GR00218-S | 39127 | CG32047 | | AMB29917 | 0.18 | none | | no | | Hippo pathway regulation | Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila | Wehr et al. | 2013 | 23263283 | Cell line | S2R+ | Hippo pathway reporter | Luminescence | np | Genome-wide | dsRNA | Z-score | > 3 OR < -3 | Author-submitted data. Primary screen | GR00311-A | 39127 | FBgn0053696 | CG33696 | DRSC08992 | np | none | | | | Actin and microtubule morphology | Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype | Rohn et al. | 2011 | 21893601 | Cell line | S2R+ | Alpha-tubulin and F-actin protein expression | Fluorescence | DRSC | Genome-wide | dsRNA | Visual inspection | np | Exact phenotypes are shown in the comment section. Several genes were indicated as hits but no phenotype was provided. The screen data plus images is available at http://jcb-dataviewer.rupress.org/jcb/browse/4609/S2. | GR00311-A | 39127 | FBgn0053696 | CG33696 | DRSC10224 | np | none | | | | Actin and microtubule morphology | Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype | Rohn et al. | 2011 | 21893601 | Cell line | S2R+ | Alpha-tubulin and F-actin protein expression | Fluorescence | DRSC | Genome-wide | dsRNA | Visual inspection | np | Exact phenotypes are shown in the comment section. Several genes were indicated as hits but no phenotype was provided. The screen data plus images is available at http://jcb-dataviewer.rupress.org/jcb/browse/4609/S2. | GR00315-A-1 | 39127 | CG33696 | CG33696 | 101076 | np | none | | | | Follicular epithelium development (1) | A genome-scale in vivo RNAi analysis of epithelial development in Drosophila identifies new proliferation domains outside of the stem cell niche | Berns et al. | 2014 | 24762813 | Tissue | Escargot-GAL4 and GR1-GAL4, GR1-GAL4, traffic jam-GAL4 | Follicular epithelium morphology | Fluorescence | VDRC KK | Random genes | UAS-IR construct | Visual inspection | np | Further classification screen available, see follicular epithelium development (2). | GR00335-A | 39127 | FBgn0053696 | CG33696 | JF03017 | np | none | | | | Germline stem cell (GSC) regulation | A Regulatory Network of Drosophila Germline Stem Cell Self-Renewal | Yan et al. | 2014 | 24576427 | Tissue | MTD-GAL4 or UAS-dcr2; nanos-GAL4 | Spectrin and vasa protein expression | Fluorescence | TRiP | Selected genes | UAS-IR construct | Visual inspection | np | More detailed phenotypes for some genes are shown in the comment. Various VALIUM vectors were used. | | 39127 | FBgn0053696 | np | np | sp | none | | | | | | | | | | | | | | | | | | | GR00367-S | 39127 | CG33696 | | 101076 | np | none | | | VDRC | Drosophila airway maturation | Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes | Hosono et al. | 2015 | 26551273 | Tissue | btl-GAL4 | Liquid clearance defect and viability | Visual inspection | VDRC, Trip, NIG | Genome-wide | UAS-IR construct | Frequency | >30% | | GR00388-A | 39127 | CG33696 | | BL28380 | | none | | | | Regulation of intestinal stem cells (ISC) | Genome-wide RNAi Screen Identifies Networks Involved in Intestinal Stem Cell Regulation in Drosophila | Zeng et al. | 2015 | 25704823 | Tissue | act5C-GAL4 | Viability | Visual inspection | VDRC and BDSC | Genome-wide | UAS-IR construct | np | np | Lethal transgenic lines identified from the primary screen were crossed with temperature-sensitive esg-GAL4 flies. Phenotypes of ISCs from the dissected midguts are shown in the "Comment" section. | GR00388-A | 39127 | CG33696 | | GD45652 | | Lethal | | | | Regulation of intestinal stem cells (ISC) | Genome-wide RNAi Screen Identifies Networks Involved in Intestinal Stem Cell Regulation in Drosophila | Zeng et al. | 2015 | 25704823 | Tissue | act5C-GAL4 | Viability | Visual inspection | VDRC and BDSC | Genome-wide | UAS-IR construct | np | np | Lethal transgenic lines identified from the primary screen were crossed with temperature-sensitive esg-GAL4 flies. Phenotypes of ISCs from the dissected midguts are shown in the "Comment" section. | GR00388-A | 39127 | CG33696 | | GD23222 | | Lethal | | | | Regulation of intestinal stem cells (ISC) | Genome-wide RNAi Screen Identifies Networks Involved in Intestinal Stem Cell Regulation in Drosophila | Zeng et al. | 2015 | 25704823 | Tissue | act5C-GAL4 | Viability | Visual inspection | VDRC and BDSC | Genome-wide | UAS-IR construct | np | np | Lethal transgenic lines identified from the primary screen were crossed with temperature-sensitive esg-GAL4 flies. Phenotypes of ISCs from the dissected midguts are shown in the "Comment" section. |