| GR00002-A | 39753 | FBgn0003691 | th | DRSC11404 | -2.891251609 | Decreased lipid droplet area | | yes | | Lipid storage | COPI complex is a regulator of lipid homeostasis. | Beller et al. | 2008 | 19067489 | Cell line | Kc167 | Nuclear to lipid droplet cross-sectional area | Fluorescence | np | Genome-wide | dsRNA | B-score | > 2 OR < -1.7 | Additional information about a secondary screen with non-overlaping dsRNAs | GR00002-A | 39753 | FBgn0003691 | th | DRSC11404 | 0.086782514 | Decreased lipid droplet area | | yes | | Lipid storage | COPI complex is a regulator of lipid homeostasis. | Beller et al. | 2008 | 19067489 | Cell line | Kc167 | Nuclear to lipid droplet cross-sectional area | Fluorescence | np | Genome-wide | dsRNA | B-score | > 2 OR < -1.7 | Additional information about a secondary screen with non-overlaping dsRNAs | GR00002-A | 39753 | FBgn0003691 | th | DRSC11404 | -4.440245615 | Decreased lipid droplet area | | yes | | Lipid storage | COPI complex is a regulator of lipid homeostasis. | Beller et al. | 2008 | 19067489 | Cell line | Kc167 | Nuclear to lipid droplet cross-sectional area | Fluorescence | np | Genome-wide | dsRNA | B-score | > 2 OR < -1.7 | Additional information about a secondary screen with non-overlaping dsRNAs | GR00007-A-0 | 39753 | FBgn0260635 | | DRSC11404 | np | Cell loss | | no | | Neural outgrowth | Identification of neural outgrowth genes using genome-wide RNAi. | Sepp et al. | 2008 | 18604272 | Cell line | Primary neural cells | Morphology | High content (microscopy) | DRSC | | dsRNA | Visual inspection | np | | GR00012-A-3 | 39753 | CG12284, CG15179 | diap1, CG15179 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG15520 | diap1, capa | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG13380 | diap1, CG13380 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG30069 | diap1, CG30069 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG15594 | diap1, CG15594 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG7789 | diap1, CG7789 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG16959 | diap1, CG16959 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG12306 | diap1, polo | np | np | Increased viability with diap1 RNAi | | yes | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG6712 | diap1, CG6712 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG11251 | diap1, CG11251 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG3297 | diap1, mnd | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG15438 | diap1, CG15438 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG6642 | diap1, a10 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG10858 | diap1, CG10858 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG16726 | diap1, CG16726 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG12232 | diap1, Gaplha73B | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG11798 | diap1, chn | np | np | Increased viability with diap1 RNAi | | yes | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG8090 | diap1, dronc | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG7438 | diap1, myo31DF | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CC15855 | diap1, eip63F-1 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG2150 | diap1, sec23 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG12170 | diap1, CG12170 | np | np | Increased viability with diap1 RNAi | | yes | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG11241 | diap1, CG11241 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG5591 | diap1, CG5591 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG8029 | diap1, CG8029 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG31629 | diap1, pvf3 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG11988 | diap1, neur | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG15147 | diap1, CG15147 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG10725 | diap1, CG10725 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG3894 | diap1, CG3894 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG30285 | diap1, CG30285 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG14740 | diap1, CG14740 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG5410 | diap1, dMiro | np | np | Increased viability with diap1 RNAi | | yes | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG9258 | diap1, nrv1 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG15013 | diap1, dy1 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG31674 | diap1, CG31674 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG3948 | diap1, zetacop | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG31349 | diap1, pyd | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG31794 | diap1, pax | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG1358 | diap1, CG1358 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG7480 | diap1, pgant35A | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG7375 | diap1, NEDD8 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG18139 | diap1, CG18139 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG11989 | diap1, dARD1 | np | np | Increased viability with diap1 RNAi | | yes | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG2275 | diap1, jra | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG4781 | diap1, CG4781 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00012-A-3 | 39753 | CG12284, CG6311 | diap1, CG6311 | np | np | Increased viability with diap1 RNAi | | no | | Caspase activation in apoptosis (3) - combinatorial effect with diap1 RNAi | A genome-wide RNAi screen reveals multiple regulators of caspase activation. | Yi et al. | 2007 | 17998402 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | HFA | Selected genes | dsRNA | p-value | < 0.05 | | GR00013-A | 39753 | CG12284 | th | np | np | Decreased Chlamydia caviae infection | | yes | | Chlamydia caviae infection | RNAi screen in Drosophila cells reveals the involvement of the Tom complex in Chlamydia infection. | Derre et al. | 2007 | 17967059 | Cell line | SL2 | Chlamydia MOMP and LPS expression and DNA content | Fluorescence | np | Genome-wide | dsRNA | Visual inspection | np | Additional information about secondary screens | GR00021-A-0 | 39753 | FBgn0260635 | | DRSC11404 | strong | ERK activation reduced | | no | | ERK signaling | A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling. | Friedman et al. | 2006 | 17086199 | Cell line | S2R+ | ERK signaling | Fluorescence | DRSC | | dsRNA | Weak, moderate, strong | np | | GR00026-A-0 | 39753 | FBgn0260635 | thread | np | np | Morphology | | no | | Cell morphology | A functional genomic analysis of cell morphology using RNA interference. | Kiger et al. | 2003 | 14527345 | Cell line | Kc167, S2R+ | Morphology | High content (microscopy) | Custom-made | | dsRNA | Visual inspection | np | | GR00031-A-1 | 39753 | | th | HFA11404 | 7 | Decreased cell number and viability | | yes | | Cell growth and viability (1) | Genome-wide RNAi analysis of growth and viability in Drosophila cells. | Boutros et al. | 2004 | 14764878 | Cell line | Kc167 | Cell number and viability | Luminescence | Custom-made (HFA) | Genome-wide | dsRNA | Z-score | > | | GR00031-A-2 | 39753 | | th | HFA11404 | 6.1 | Decreased cell number and viability | | no | | Cell growth and viability (2) | Genome-wide RNAi analysis of growth and viability in Drosophila cells. | Boutros et al. | 2004 | 14764878 | Cell line | S2R+ | Cell number and viability | Luminescence | Custom-made (HFA) | Genome-wide | dsRNA | Z-score | > | | GR00036-A | 39753 | CG12284 | th | DRSC11404 | strong | Decreased GFP protein expression | | yes | decreased intracellular infection | Intracellular Listeria monocytogenes infection | Genome-wide RNAi screen for host factors required for intracellular bacterial infection. | Agaisse et al. | 2005 | 16020693 | Cell line | SL2 | GFP protein expression | Fluorescence | DRSC | Genome-wide | dsRNA | Visual inspection | np | | GR00045-A-0 | 39753 | FBgn0260635 | | DRSC11404 | -2.29 | Decreased Hedgehog reporter activity | | no | | Hedgehog signaling | A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. | Nybakken et al. | 2005 | 16311596 | Cell line | Clone 8 | Hedgehog signaling | Dual luciferase | DRSC | | dsRNA | Z-score | > | | GR00046-A-1 | 39753 | FBgn0003691 | Th | DRSC11404 | 12 | Decreased M. fortuitum intracellular infection | measurement after 3 days | yes | | Mycobacterial infection (1) - M. fortuitum infection | Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection. | Philips et al. | 2005 | 16020694 | Cell line | S2 | map24::GFP and map49::GFP protein expression | Fluorescence | np | Genome-wide | dsRNA | Z-score | > | | GR00046-A-2 | 39753 | FBgn0003691 | Th | DRSC11404 | np | Decreased E. coli phagocytosis | | no | | Mycobacterial infection (2) - E. coli phagocytosis | Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection. | Philips et al. | 2005 | 16020694 | Cell line | S2 | Intracellular FITC-E. coli uptake | Fluorescence | np | Selected genes | dsRNA | p-value | < 0.01 | | GR00047-A-1 | 39753 | FBgn0003691 | th | DRSC11404 | sp | Decreased horseradish peroxidase protein expression | | no | | Constitutive protein secretion and Golgi organization (1) | Functional genomics reveals genes involved in protein secretion and Golgi organization. | Bard et al. | 2006 | 16452979 | Cell line | S2 | Horseradish peroxidase protein expression | Luminescence | | Genome-wide | dsRNA | Z-score | < -1.5 | | | 39753 | FBgn0003691 | th | GH15335 | sp | Decreased G2 DNA content, decreased G1 cell size, decreased viability, increased cytokinesis | | yes | library: DGC1 | | | | | | | | | | | | | | | | GR00048-A-2 | 39753 | FBgn0003691 | th | np | 1.333 | none | | yes | | Cell size and cell-cycle regulation (2) | Identification of pathways regulating cell size and cell-cycle progression by RNAi. | Bjӧrklund et al. | 2006 | 16496002 | Cell line | S2 | Proliferation and viability | Colorimetrics | | Selected genes | dsRNA | MTS metabolic activity | > 2.5 standard deviations | Additional information about the primary screen (pooled library) and a secondary screen (number of binucleate cells) | GR00048-A-3 | 39753 | FBgn0003691 | th | np | 430 | none | | yes | | Cell size and cell-cycle regulation (3) | Identification of pathways regulating cell size and cell-cycle progression by RNAi. | Bjӧrklund et al. | 2006 | 16496002 | Cell line | S2 | Cell number | Fluorescence | | Selected genes | dsRNA | Average cell number per field | > 2 standard deviations | Additional information about the primary screen (pooled library) and a secondary screen (number of binucleate cells) | | 39753 | CG12284 | th | np | np | Disorganization and loss of neurons of ventral nerve cord and peripheral nervous system | | no | novel phenotype | | | | | | | | | | | | | | | | GR00062-A | 39753 | FBgn0003691 | th | np | 6 | Decreased Ca2+ influx | | | | Ca2+ channel regulation | CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. | Vig et al. | 2006 | 16645049 | Cell line | S2R+ | Ca2+ influx | Fluorescence | np | Genome-wide | dsRNA | Complex, sp | > | | | 39753 | FBgn0003691 | th | np | 1.181 | Increased mitochondrial citrate synthase activity, decreased viability | | yes | Renilla activity < 50% of mean | | | | | | | | | | | | | | | | GR00130-A | 39753 | FBgn0003691 | th | np | <= -2 | Decreased mutant human huntingtin aggregation | | no | | Mutant human huntingtin aggregation | RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation. | Doumanis et al. | 2009 | 19789644 | Cell line | BG2-c2 | Nhtt(62Q)EGFP aggregate number and size | Fluorescence | OpenBiosystems RNAi library | Selected genes | dsRNA | Z-score | Suppressor: < | | GR00131-A-1 | 39753 | | th | DRSC11404 | > 75 | Altered mitochondrial Ca2+ and/or H+ levels | | no | | Mitochondrial Ca2+/H+ antiporter regulation (1) | Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter. | Jiang et al. | 2009 | 19797662 | Cell line | S2 | mt-pericam protein expression (reporter of mitochondrial Ca2+ and H+ levels) | Fluorescence | np | Genome-wide | dsRNA | Percentage inhibition | Class I: > 75; class II: 50-75; class III: 25–50 | | GR00134-A-1 | 39753 | CG12284 | th | 37090 | np | Lethal | | yes | late larval | Muscle morphogenesis and function (1) | Systematic genetic analysis of muscle morphogenesis and function in Drosophila. | Schnorrer et al. | 2010 | 20220848 | Tissue | Mef2-GAL4 | Posture, locomotion, flight and viability | Visual inspection | np | Genome-wide | UAS-IR construct | rp | S19 > 0.5 | | GR00134-A-3 | 39753 | CG12284 | th | 37090 | np | none | | no | | Muscle morphogenesis and function (3) | Systematic genetic analysis of muscle morphogenesis and function in Drosophila. | Schnorrer et al. | 2010 | 20220848 | Tissue | Mef2-GAL4 | ZCL0663 protein expression | Fluorescence | np | Selected genes | UAS-IR construct | np | np | | GR00144-A-4 | 39753 | CG12284 | | 37090 | sp | Completely lethal (before pupal) | | no | | Notch pathway regulation (4) | Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. | Mummery-Widmer et al. | 2009 | 19363474 | Tissue | pnr-GAL4 | External sensory organ morphology and viability | Visual inspection | np | Genome-wide | UAS-IR construct | Phenotype strength | np | | GR00159-A | 39753 | | th | DRSC11404 | np | none | | no | | Muscle assembly and maintenance | RNA interference screening in Drosophila primary cells for genes involved in muscle assembly and maintenance. | Bai et al. | 2008 | 18359903 | Primary cells | primary embryonic cells | Muscle cell morphology | Fluorescence | np | Selected and random genes | dsRNA | Percentage of muscles with a given phenotype | Severe: > 80 %; medium: ~ 50 % | | GR00170-A-1 | 39753 | | thread | DRSC11404 | -4.9 | none | | no | decreased cell viability or Sanger collection sequence | HIF-dependent transcription (1) | Drosophila genome-wide RNAi screen identifies multiple regulators of HIF-dependent transcription in hypoxia. | Dekanty et al. | 2010 | 20585616 | Cell line | S2 | Hypoxia inducible HRE reporter | Luminescence | DRSC 1.0 library | Genome-wide | dsRNA | Z-score | < | | GR00175-A | 39753 | CG12284 | th | DRSC30906 | 0.3268897706833 | none | | no | | Hh pathway regulation | A case study of the reproducibility of transcriptional reporter cell-based RNAi screens in Drosophila. | DasGupta et al. | 2007 | 17903264 | Cell line | rp | rp | Luminescence | DRSC-v | Selected genes | dsRNA | Average fractional change | Complex criteria | | GR00175-A | 39753 | CG12284 | th | DRSC30905 | 0.739622606753532 | Upregulation of Hh pathway | | no | | Hh pathway regulation | A case study of the reproducibility of transcriptional reporter cell-based RNAi screens in Drosophila. | DasGupta et al. | 2007 | 17903264 | Cell line | rp | rp | Luminescence | DRSC-v | Selected genes | dsRNA | Average fractional change | Complex criteria | | GR00189-A-3 | 39753 | FBgn0260635 | th | np | np | none | | no | | Notch pathway regulation (3) | A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network. | Saj et al. | 2010 | 20493818 | Tissue | GMR-GAL4 | Notch pathway reporter | Fluorescence | Notch pathway component enriched RNAi library | Selected genes | UAS-IR construct | Average fluorescent intensity | Complex criteria | | GR00201-A-1 | 39753 | FBgn0003691 | th | Thread (Baum_Lab) | np | none | | yes | | Actin organization and cell morphology (1) | Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology. | Liu et al. | 2009 | 19265526 | Cell line | S2 | alpha-Tubulin and F-actin protein expression | Fluorescence | Custom-made | Kinases | dsRNA | Visual inspection | np | | GR00201-A-2 | 39753 | FBgn0003691 | th | Thread (Baum_Lab) | np | none | | yes | | Actin organization and cell morphology (2) | Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology. | Liu et al. | 2009 | 19265526 | Cell line | S2R+ | alpha-Tubulin and F-actin protein expression | Fluorescence | Custom-made | Kinases | dsRNA | Visual inspection | np | | GR00201-A-3 | 39753 | FBgn0003691 | th | Thread (Baum_Lab) | np | none | | yes | | Actin organization and cell morphology (3) | Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology. | Liu et al. | 2009 | 19265526 | Cell line | Kc167 | alpha-Tubulin and F-actin protein expression | Fluorescence | Custom-made | Kinases | dsRNA | Visual inspection | np | | GR00201-A-4 | 39753 | FBgn0003691 | th | Thread (Baum_Lab) | np | none | | yes | | Actin organization and cell morphology (4) | Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology. | Liu et al. | 2009 | 19265526 | Cell line | BG2-c2 | alpha-Tubulin and F-actin protein expression | Fluorescence | Custom-made | Kinases | dsRNA | Visual inspection | np | | GR00201-A-5 | 39753 | FBgn0003691 | th | Thread (Baum_Lab) | np | none | | yes | | Actin organization and cell morphology (5) | Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology. | Liu et al. | 2009 | 19265526 | Cell line | BG3-c1 | alpha-Tubulin and F-actin protein expression | Fluorescence | Custom-made | Kinases | dsRNA | Visual inspection | np | | GR00201-A-6 | 39753 | FBgn0003691 | th | Thread (Baum_Lab) | np | none | | no | | Actin organization and cell morphology (6) | Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology. | Liu et al. | 2009 | 19265526 | Cell line | BG3-c2 | alpha-Tubulin and F-actin protein expression | Fluorescence | Custom-made | Kinases | dsRNA | Visual inspection | np | | GR00214-A-1 | 39753 | FBgn0260635 | th | DRSC11404 | -3.81 | Decreased ERK phosphorylation after EGF stimulation | 10 minutes EGF stimulation | yes | | RTK-Ras-ERK pathway regulation (1) | Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. | Friedman et al. | 2011 | 22028469 | Cell line | S2R+ | ERK phosphorylation | Fluorescence | np | Genome-wide | dsRNA | Z-score | > 1.5 OR < -1.5 | | GR00214-A-1 | 39753 | FBgn0260635 | th | DRSC11404 | -2.7 | Decreased ERK phosphorylation after EGF stimulation | 0 minutes EGF stimulation | yes | | RTK-Ras-ERK pathway regulation (1) | Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. | Friedman et al. | 2011 | 22028469 | Cell line | S2R+ | ERK phosphorylation | Fluorescence | np | Genome-wide | dsRNA | Z-score | > 1.5 OR < -1.5 | | GR00214-A-2 | 39753 | FBgn0260635 | th | DRSC11404 | -0.58 | none | 10 minutes sSpitz stimulation | no | | RTK-Ras-ERK pathway regulation (2) | Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. | Friedman et al. | 2011 | 22028469 | Cell line | Kc167 | ERK phosphorylation | Fluorescence | np | Genome-wide | dsRNA | Z-score | > 1.5 OR < -1.5 | | GR00214-A-2 | 39753 | FBgn0260635 | th | DRSC11404 | 16.11 | Increased ERK phosphorylation after sSpitz and EGF stimulation | 30 minutes sSpitz stimulation | no | | RTK-Ras-ERK pathway regulation (2) | Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. | Friedman et al. | 2011 | 22028469 | Cell line | Kc167 | ERK phosphorylation | Fluorescence | np | Genome-wide | dsRNA | Z-score | > 1.5 OR < -1.5 | | GR00218-S | 39753 | CG12284 | th | AMB28438 | -3.05 | Upregulation of Hippo pathway | | no | | Hippo pathway regulation | Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila | Wehr et al. | 2013 | 23263283 | Cell line | S2R+ | Hippo pathway reporter | Luminescence | np | Genome-wide | dsRNA | Z-score | > 3 OR < -3 | Author-submitted data. Primary screen | GR00239-A-1 | 39753 | CG12284 | | 12284R | sp | none | | no | | Glycosylation regulation (1) | Identification of genes required for neural-specific glycosylation using functional genomics. | Yamamoto-Hino et al. | 2010 | 21203496 | Tissue | GMR-GAL4 | Chaoptin (Chp) protein expression, alpha1,3-fucose, alpha1,6-fucose, (GlcNAc)n, GlcNAcb1-4GlcNAc and mannose Chp glycosylation and viability | Luminescence | np | Selected genes | UAS-IR construct | Z-score | > 3 | | GR00308-A | 39753 | CG12284 | th | np | 4 | Decreased cell aggregation | | | | Cadherin-mediated cell-cell adhesion | A genome-wide screen identifies conserved protein hubs required for cadherin-mediated cell–cell adhesion | Toret et al. | 2014 | 24446484 | Cell line | S2 | Cell aggregation | Fluorescence | V2 RNAi library (Thermo Fisher Scientific) | Genome-wide | dsRNA | Visual inspection; average of 3 replicates; 0 | > 1.5 | Additional secondary screen available. S2 cells stably express DE-cadherin. | GR00311-A | 39753 | FBgn0260635 | th | DRSC11404 | np | No cells | | | | Actin and microtubule morphology | Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype | Rohn et al. | 2011 | 21893601 | Cell line | S2R+ | Alpha-tubulin and F-actin protein expression | Fluorescence | DRSC | Genome-wide | dsRNA | Visual inspection | np | Exact phenotypes are shown in the comment section. Several genes were indicated as hits but no phenotype was provided. The screen data plus images is available at http://jcb-dataviewer.rupress.org/jcb/browse/4609/S2. | GR00335-A | 39753 | FBgn0260635 | th | HMS00752 | np | F1 lethal | | | F1 embryonic lethal | Germline stem cell (GSC) regulation | A Regulatory Network of Drosophila Germline Stem Cell Self-Renewal | Yan et al. | 2014 | 24576427 | Tissue | MTD-GAL4 or UAS-dcr2; nanos-GAL4 | Spectrin and vasa protein expression | Fluorescence | TRiP | Selected genes | UAS-IR construct | Visual inspection | np | More detailed phenotypes for some genes are shown in the comment. Various VALIUM vectors were used. | | 39753 | FBgn0260635 | np | np | -2.56 | Increased transposon expression | | | fold change: 5.31 | | | | | | | | | | | | | | | | | 39753 | np | np | HFA11404 | 1.85 | none | | | fold change: 0.48 | | | | | | | | | | | | | | | | | 39753 | FBgn0260635 | np | np | sp | none | | | | | | | | | | | | | | | | | | | GR00339-A-2 | 39753 | FBgn0260635 | th | 33597 | na | Developmental defect | | | | piRNA pathway regulation (2) | A Genome-wide RNAi Screen Draws a Genetic Framework for Transposon Control and Primary piRNA Biogenesis in Drosophila | Muerdter et al. | 2013 | 23665228 | Tissue | traffic jam GAL4 | Gypsy and ZAM transposon expression | qPCR | VDRC (GD, KK) and TRiP | Selected genes | UAS-IR construct | Fold change | > | Following transposons were used for scoring: Gypsy for KK and ZAM for GD RNAi lines. TRIP reagents als TRIP_11111 dargestellt, Suchbarkeit? Developmental defect: wurden nicht gemessen, passt np als Score? | GR00388-A | 39753 | CG12284 | | BL33597 | | none | | | | Regulation of intestinal stem cells (ISC) | Genome-wide RNAi Screen Identifies Networks Involved in Intestinal Stem Cell Regulation in Drosophila | Zeng et al. | 2015 | 25704823 | Tissue | act5C-GAL4 | Viability | Visual inspection | VDRC and BDSC | Genome-wide | UAS-IR construct | np | np | Lethal transgenic lines identified from the primary screen were crossed with temperature-sensitive esg-GAL4 flies. Phenotypes of ISCs from the dissected midguts are shown in the "Comment" section. | GR00388-A | 39753 | CG12284 | | GD37090 | | none | | | | Regulation of intestinal stem cells (ISC) | Genome-wide RNAi Screen Identifies Networks Involved in Intestinal Stem Cell Regulation in Drosophila | Zeng et al. | 2015 | 25704823 | Tissue | act5C-GAL4 | Viability | Visual inspection | VDRC and BDSC | Genome-wide | UAS-IR construct | np | np | Lethal transgenic lines identified from the primary screen were crossed with temperature-sensitive esg-GAL4 flies. Phenotypes of ISCs from the dissected midguts are shown in the "Comment" section. |