| GR00002-A | 43651 | FBgn0011739 | wts | DRSC17096 | -0.210911332 | none | | no | | Lipid storage | COPI complex is a regulator of lipid homeostasis. | Beller et al. | 2008 | 19067489 | Cell line | Kc167 | Nuclear to lipid droplet cross-sectional area | Fluorescence | np | Genome-wide | dsRNA | B-score | > 2 OR < -1.7 | Additional information about a secondary screen with non-overlaping dsRNAs | GR00002-A | 43651 | FBgn0011739 | wts | DRSC17096 | 0.374395735 | none | | no | | Lipid storage | COPI complex is a regulator of lipid homeostasis. | Beller et al. | 2008 | 19067489 | Cell line | Kc167 | Nuclear to lipid droplet cross-sectional area | Fluorescence | np | Genome-wide | dsRNA | B-score | > 2 OR < -1.7 | Additional information about a secondary screen with non-overlaping dsRNAs | GR00002-A | 43651 | FBgn0011739 | wts | DRSC22975 | 2.82791102 | none | | no | | Lipid storage | COPI complex is a regulator of lipid homeostasis. | Beller et al. | 2008 | 19067489 | Cell line | Kc167 | Nuclear to lipid droplet cross-sectional area | Fluorescence | np | Genome-wide | dsRNA | B-score | > 2 OR < -1.7 | Additional information about a secondary screen with non-overlaping dsRNAs | GR00002-A | 43651 | FBgn0011739 | wts | DRSC22975 | -0.799617567 | none | | no | | Lipid storage | COPI complex is a regulator of lipid homeostasis. | Beller et al. | 2008 | 19067489 | Cell line | Kc167 | Nuclear to lipid droplet cross-sectional area | Fluorescence | np | Genome-wide | dsRNA | B-score | > 2 OR < -1.7 | Additional information about a secondary screen with non-overlaping dsRNAs | GR00030-A-1 | 43651 | CG12072 | wts | wts | sp | Increased G1 DNA content | | yes | | Cell cycle regulation (1) | Genome-wide survey of protein kinases required for cell cycle progression. | Bettencourt-Dias et al. | 2004 | 15616552 | Cell line | S2 | alpha-tubulin and gamma-tubulin protein expression, histone H3 phosphorylation and DNA content | Flow cytometry | rp | Kinases | dsRNA | Confidence intervals | Complex criteria | | GR00030-A-2 | 43651 | CG12072 | wts | wts | np | Increased G1 DNA content, increased cell size | | no | weak phenotype | Cell cycle regulation (2) | Genome-wide survey of protein kinases required for cell cycle progression. | Bettencourt-Dias et al. | 2004 | 15616552 | Cell line | S2 | Histone H3 phosphorylation, Cyclin A and Cyclin B protein expression | Flow cytometry | rp | Kinases and kinase regulators | dsRNA | np | np | | GR00031-A-1 | 43651 | | wts | HFA17096 | 4.3 | Decreased cell number and viability | | yes | | Cell growth and viability (1) | Genome-wide RNAi analysis of growth and viability in Drosophila cells. | Boutros et al. | 2004 | 14764878 | Cell line | Kc167 | Cell number and viability | Luminescence | Custom-made (HFA) | Genome-wide | dsRNA | Z-score | > | | GR00031-A-2 | 43651 | | wts | HFA17096 | 5.3 | Decreased cell number and viability | | no | | Cell growth and viability (2) | Genome-wide RNAi analysis of growth and viability in Drosophila cells. | Boutros et al. | 2004 | 14764878 | Cell line | S2R+ | Cell number and viability | Luminescence | Custom-made (HFA) | Genome-wide | dsRNA | Z-score | > | | GR00037-A-1 | 43651 | | wts | np | > 1.5 | Upregulation of JAK/STAT pathway | | no | | JAK/STAT pathway regulation (1) | Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. | Baeg et al. | 2005 | 16055650 | Cell line | S2-NP | JAK/STAT pathway reporter | Luminescence | rp | Genome-wide | dsRNA | Fold change of relative luciferase units | Complex criteria | | GR00040-A-0 | 43651 | FBgn0011739 | | DRSC17096 | 7.8 | Increased Wnt reporter activity | | no | | Wnt signaling | Functional genomic analysis of the Wnt-wingless signaling pathway. | DasGupta et al. | 2005 | 15817814 | Cell line | Clone 8 | Wnt signaling | Dual luciferase | DRSC | | dsRNA | Z-score | > | | GR00047-A-1 | 43651 | FBgn0011739 | wts | DRSC17096 | sp | Decreased horseradish peroxidase protein expression | | no | | Constitutive protein secretion and Golgi organization (1) | Functional genomics reveals genes involved in protein secretion and Golgi organization. | Bard et al. | 2006 | 16452979 | Cell line | S2 | Horseradish peroxidase protein expression | Luminescence | | Genome-wide | dsRNA | Z-score | < -1.5 | | | 43651 | FBgn0011739 | wts | SD19495 | sp | none | | no | library: DGC2 | | | | | | | | | | | | | | | | | 43651 | FBgn0011739 | wts | CT4806 | sp | none | | no | library: PHOSPHO | | | | | | | | | | | | | | | | GR00062-A | 43651 | FBgn0011739 | wts | np | 2 | Decreased Ca2+ influx | | | multiple potential off-targets | Ca2+ channel regulation | CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. | Vig et al. | 2006 | 16645049 | Cell line | S2R+ | Ca2+ influx | Fluorescence | np | Genome-wide | dsRNA | Complex, sp | > | | GR00128-A-1 | 43651 | FBgn0011739 | CG12072 | DRSC17096 | sp | Synthetic lethal with methyl methanesulphonate | | no | | Combinatorial effect with methyl methanesulphonate (1) | A network of conserved damage survival pathways revealed by a genomic RNAi screen. | Ravi et al. | 2009 | 19543366 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | Version 1 | Genome-wide | dsRNA | rp | rp | Additional information about the primary screen | GR00128-A-2 | 43651 | FBgn0011739 | CG12072 | DRSC32015 | sp | none | | no | | Combinatorial effect with methyl methanesulphonate (2) | A network of conserved damage survival pathways revealed by a genomic RNAi screen. | Ravi et al. | 2009 | 19543366 | Cell line | Kc167 | Viability (synthetic lethal) | Luminescence | Version 1 | Selected genes | dsRNA | rp | rp | | GR00130-A | 43651 | FBgn0011739 | wts | np | <= -2 | Decreased mutant human huntingtin aggregation | | no | | Mutant human huntingtin aggregation | RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation. | Doumanis et al. | 2009 | 19789644 | Cell line | BG2-c2 | Nhtt(62Q)EGFP aggregate number and size | Fluorescence | OpenBiosystems RNAi library | Selected genes | dsRNA | Z-score | Suppressor: < | | GR00134-A-1 | 43651 | CG12072 | wts | 9928 | np | none | | no | | Muscle morphogenesis and function (1) | Systematic genetic analysis of muscle morphogenesis and function in Drosophila. | Schnorrer et al. | 2010 | 20220848 | Tissue | Mef2-GAL4 | Posture, locomotion, flight and viability | Visual inspection | np | Genome-wide | UAS-IR construct | rp | S19 > 0.5 | | GR00135-A-1 | 43651 | CG12072 | wts | 9928 | -1.17 | none | | yes | | Heat nociception (1) | A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. | Neely et al. | 2010 | 21074052 | Organism | elav-GAL4 | Noxious heat avoidance and viability | Fly count | np | Genome-wide | UAS-IR construct | Z-score | > 1.65 | Additional information about secondary screens (geotactic, phototaxis, and temperature sensitivity) | GR00138-A-1 | 43651 | CG12072 | | 9928 | 1 | none | | no | | Heart development and function (1) | A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. | Neely et al. | 2010 | 20371351 | Tissue | TinCΔ4 12a-Gal4 | Viability | Fly count | np | Selected genes | UAS-IR construct | Developmental lethality | < | | GR00139-A | 43651 | | wts | 9928 | sp | Lethal | | no | | Fly viability and adult morphology | A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. | Dietzl et al. | 2007 | 17625558 | Organism | Act5C-GAL4 | Adult morphology and viability | Visual inspection | Custom-made | Selected and random genes | UAS-IR construct | Phenotype strength | np | Additional information about secondary screens (MS1096-GAL4, ey-GAL4, GMR-GAL4 and pnr-GAL4) | GR00142-A-1 | 43651 | CG12072 | wts | 9928 | -0.314606741573033 | none | | no | | Serratia marcescens infection (1) | Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. | Cronin et al. | 2009 | 19520911 | Organism | HSP70-GAL4; TubGAL80ts | Heat shock and viability | Fly count | np | Random genes | UAS-IR construct | Days life time (LT50) | < -1.5 SD OR > 2 SD | | GR00144-A-4 | 43651 | CG12072 | | 9927 | 0 | none | | no | not lethal | Notch pathway regulation (4) | Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. | Mummery-Widmer et al. | 2009 | 19363474 | Tissue | pnr-GAL4 | External sensory organ morphology and viability | Visual inspection | np | Genome-wide | UAS-IR construct | Phenotype strength | np | | GR00144-A-4 | 43651 | CG12072 | | 9928 | sp | Colour defects, notum malformation migration, overproliferation | | no | not lethal | Notch pathway regulation (4) | Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. | Mummery-Widmer et al. | 2009 | 19363474 | Tissue | pnr-GAL4 | External sensory organ morphology and viability | Visual inspection | np | Genome-wide | UAS-IR construct | Phenotype strength | np | | GR00157-A | 43651 | | wts | DRSC32015 | 0.02 | none | | no | | Wg pathway regulation | A case study of the reproducibility of transcriptional reporter cell-based RNAi screens in Drosophila. | DasGupta et al. | 2007 | 17903264 | Cell line | rp | rp | Luminescence | DRSC-v | Selected genes | dsRNA | log ratio | > 30 % difference from control | | GR00157-A | 43651 | | wts | DRSC32016 | 0.81 | Upregulation of Wg pathway | | no | | Wg pathway regulation | A case study of the reproducibility of transcriptional reporter cell-based RNAi screens in Drosophila. | DasGupta et al. | 2007 | 17903264 | Cell line | rp | rp | Luminescence | DRSC-v | Selected genes | dsRNA | log ratio | > 30 % difference from control | | GR00170-A-1 | 43651 | | warts | DRSC17096 | -2.7 | none | | no | decreased cell viability or Sanger collection sequence | HIF-dependent transcription (1) | Drosophila genome-wide RNAi screen identifies multiple regulators of HIF-dependent transcription in hypoxia. | Dekanty et al. | 2010 | 20585616 | Cell line | S2 | Hypoxia inducible HRE reporter | Luminescence | DRSC 1.0 library | Genome-wide | dsRNA | Z-score | < | | GR00190-A-1 | 43651 | FBgn0011739 | wts | 9928 | -0.526 | none | | no | | Adiposity regulation (1) | Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. | Pospisilik et al. | 2010 | 20074523 | Organism | Hsp70-GAL4;Tub-GAL80ts | Total fly triglyceride expression | Colorimetrics | np | Genome-wide | UAS-IR construct | Triglyceride change | Z-score > 1.65 after 3 screening rounds | Additional information about the primary screen | GR00191-A-1 | 43651 | CG12072 | wts | np | np | none | | yes | | Blood cell homeostasis regulation (1) | An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis. | Avet-Rochex et al. | 2010 | 20540764 | Tissue | srp-GAL4 | Melanotic mass formation | Microscopy | np | Selected genes | UAS-IR construct | np | np | | GR00191-A-2 | 43651 | CG12072 | wts | np | np | Increased melanotic mass formation | | yes | | Blood cell homeostasis regulation (2) | An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis. | Avet-Rochex et al. | 2010 | 20540764 | Tissue | hml∆-GAL4 | Melanotic mass formation | Microscopy | np | Selected genes | UAS-IR construct | np | np | | GR00191-A-3 | 43651 | CG12072 | wts | np | 0 | none | | yes | | Blood cell homeostasis regulation (3) | An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis. | Avet-Rochex et al. | 2010 | 20540764 | Tissue | srp-GAL4 | Melanotic mass formation | Microscopy | np | Selected genes | UAS-IR construct | Tumor index | > | | GR00191-A-4 | 43651 | CG12072 | wts | np | 0 | none | | yes | | Blood cell homeostasis regulation (4) | An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis. | Avet-Rochex et al. | 2010 | 20540764 | Tissue | hml∆-GAL4 | Melanotic mass formation | Microscopy | np | Selected genes | UAS-IR construct | Tumor index | > | | GR00191-A-5 | 43651 | CG12072 | wts | np | 0 | none | | no | | Blood cell homeostasis regulation (5) | An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis. | Avet-Rochex et al. | 2010 | 20540764 | Tissue | cg-GAL4 | Melanotic mass formation | Microscopy | np | Selected genes | UAS-IR construct | Tumor index | > | | GR00194-A | 43651 | CG12072 | warts | np | np | none | | yes | actin perimeter: bottom 40, actin perimeter-1: top 40 | S2 cell spreading | A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis. | D'Ambrosio and Vale | 2010 | 21041442 | Cell line | S2U | alpha-tubulin and actin protein expression | Fluorescence | V2 RNAi library | Genome-wide | dsRNA | Complex, sp | Complex criteria | | GR00201-A-1 | 43651 | FBgn0011739 | wts | CG12072 (UCSF), wts (Baum_Lab) | np | none | | yes | | Actin organization and cell morphology (1) | Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology. | Liu et al. | 2009 | 19265526 | Cell line | S2 | alpha-Tubulin and F-actin protein expression | Fluorescence | Custom-made | Kinases | dsRNA | Visual inspection | np | | GR00201-A-2 | 43651 | FBgn0011739 | wts | CG12072 (UCSF), wts (Baum_Lab) | np | Altered cell morphology | | yes | | Actin organization and cell morphology (2) | Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology. | Liu et al. | 2009 | 19265526 | Cell line | S2R+ | alpha-Tubulin and F-actin protein expression | Fluorescence | Custom-made | Kinases | dsRNA | Visual inspection | np | | GR00201-A-3 | 43651 | FBgn0011739 | wts | CG12072 (UCSF), wts (Baum_Lab) | np | Altered cell morphology | | yes | | Actin organization and cell morphology (3) | Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology. | Liu et al. | 2009 | 19265526 | Cell line | Kc167 | alpha-Tubulin and F-actin protein expression | Fluorescence | Custom-made | Kinases | dsRNA | Visual inspection | np | | GR00201-A-4 | 43651 | FBgn0011739 | wts | CG12072 (UCSF), wts (Baum_Lab) | np | none | | yes | | Actin organization and cell morphology (4) | Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology. | Liu et al. | 2009 | 19265526 | Cell line | BG2-c2 | alpha-Tubulin and F-actin protein expression | Fluorescence | Custom-made | Kinases | dsRNA | Visual inspection | np | | GR00201-A-5 | 43651 | FBgn0011739 | wts | CG12072 (UCSF), wts (Baum_Lab) | np | none | | yes | | Actin organization and cell morphology (5) | Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology. | Liu et al. | 2009 | 19265526 | Cell line | BG3-c1 | alpha-Tubulin and F-actin protein expression | Fluorescence | Custom-made | Kinases | dsRNA | Visual inspection | np | | GR00201-A-6 | 43651 | FBgn0011739 | wts | CG12072 (UCSF), wts (Baum_Lab) | np | none | | no | | Actin organization and cell morphology (6) | Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology. | Liu et al. | 2009 | 19265526 | Cell line | BG3-c2 | alpha-Tubulin and F-actin protein expression | Fluorescence | Custom-made | Kinases | dsRNA | Visual inspection | np | | GR00202-A | 43651 | FBgn0011739 | wts | np | sp | none | | no | | Vaccinia virus infection | A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics. | Moser et al. | 2010 | 20585561 | Cell line | DL1 | Virally encoded beta-galactosidase protein expression | Fluorescence | Custom-made | Kinases, phosphatases and selected genes | dsRNA | Z-score | < -2 in both duplicates | Author-reviewed data | | 43651 | FBgn0011739 | wts | np | < -2 | Decreased BiP signal peptide and firefly luciferase fusion protein expression | | yes | | | | | | | | | | | | | | | | | GR00218-S | 43651 | CG12072 | wts | AMB34725 | 0.54 | none | | no | | Hippo pathway regulation | Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila | Wehr et al. | 2013 | 23263283 | Cell line | S2R+ | Hippo pathway reporter | Luminescence | np | Genome-wide | dsRNA | Z-score | > 3 OR < -3 | Author-submitted data. Primary screen | GR00239-A-1 | 43651 | CG12072 | | 12072R | np | Decreased Chp protein expression | | no | not detectable Chp level | Glycosylation regulation (1) | Identification of genes required for neural-specific glycosylation using functional genomics. | Yamamoto-Hino et al. | 2010 | 21203496 | Tissue | GMR-GAL4 | Chaoptin (Chp) protein expression, alpha1,3-fucose, alpha1,6-fucose, (GlcNAc)n, GlcNAcb1-4GlcNAc and mannose Chp glycosylation and viability | Luminescence | np | Selected genes | UAS-IR construct | Z-score | > 3 | | GR00282-A | 43651 | CG12072 | wts | 106174 | np | none | | | | piRNA pathway regulation | The Genetic Makeup of the Drosophila piRNA Pathway | Handler | 2013 | 23665231 | Tissue | tj-GAL4 | Gypsy transposon expression | Microscopy | VDRC | Selected genes | UAS-IR construct | Visual inspection | np | See comment for ovarian morphology data. Gene expression data shown in the comment derive from an ovarian stem cell line. VDRC library: KK and GD used, see phenotype data | GR00282-A | 43651 | CG12072 | wts | 9928 | np | none | | | | piRNA pathway regulation | The Genetic Makeup of the Drosophila piRNA Pathway | Handler | 2013 | 23665231 | Tissue | tj-GAL4 | Gypsy transposon expression | Microscopy | VDRC | Selected genes | UAS-IR construct | Visual inspection | np | See comment for ovarian morphology data. Gene expression data shown in the comment derive from an ovarian stem cell line. VDRC library: KK and GD used, see phenotype data | GR00284-A | 43651 | CG12072 | wts | 106174 | -0.5007946182334353 | none | | | | piRNA pathway regulation | A Transcriptome-wide RNAi Screen in the Drosophila Ovary Reveals Factors of the Germline piRNA Pathway | Czech et al. | 2013 | 23665227 | Tissue | nos-GAL4 | Transposon expression | qPCR | VDRC | Selected genes | UAS-IR construct | Z-score | Weak < -1.5; strong: < -2 | KK and GD libraries used (see phenotype data) | GR00311-A | 43651 | FBgn0011739 | wts | DRSC17096 | np | none | | | | Actin and microtubule morphology | Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype | Rohn et al. | 2011 | 21893601 | Cell line | S2R+ | Alpha-tubulin and F-actin protein expression | Fluorescence | DRSC | Genome-wide | dsRNA | Visual inspection | np | Exact phenotypes are shown in the comment section. Several genes were indicated as hits but no phenotype was provided. The screen data plus images is available at http://jcb-dataviewer.rupress.org/jcb/browse/4609/S2. | GR00314-A | 43651 | FBgn0011739 | wts | RNA005755 | 143.25 | Increased MAPK phosphorylation | | | | RAS-related MAPK activation | A Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS/MAPK Signaling in Drosophila | Ashton-Beaucage et al. | 2014 | 24643257 | Cell line | S2 | MAPK phosphorylation | Fluorescence | Custom-made | Genome-wide | dsRNA | pMAPK signal (%GFP dsRNA) | np | S2 cells stably expressed pMet-RasV12. See comment for hits in validation screens. Data deposited at http://www.bioinfo.iric.ca/iricrnai | GR00315-A-1 | 43651 | CG12072 | wts | 106174 | np | Effect on follicular epithelium morphology | | | further phenotype data in classification screen | Follicular epithelium development (1) | A genome-scale in vivo RNAi analysis of epithelial development in Drosophila identifies new proliferation domains outside of the stem cell niche | Berns et al. | 2014 | 24762813 | Tissue | Escargot-GAL4 and GR1-GAL4, GR1-GAL4, traffic jam-GAL4 | Follicular epithelium morphology | Fluorescence | VDRC KK | Random genes | UAS-IR construct | Visual inspection | np | Further classification screen available, see follicular epithelium development (2). | GR00315-A-2 | 43651 | CG12072 | wts | 106174 | np | Defect in formation and maturation phase | | | | Follicular epithelium development (2) | A genome-scale in vivo RNAi analysis of epithelial development in Drosophila identifies new proliferation domains outside of the stem cell niche | Berns et al. | 2014 | 24762813 | Tissue | traffic jam-GAL4 | Follicular epithelium morphology | Fluorescence | VDRC KK | Selected genes | UAS-IR construct | Visual inspection | np | For more detailed phenotypes sp. Cell morphology was analized by aPKC and DLG protein expression. Additional validation screens available. | GR00326-A | 43651 | FBgn0011739 | wts | 12072 | np | none | | | | Synapse formation and maintenance | A large-scale RNAi screen identifies functional classes of genes shaping synaptic development and maintenance | Valakh et al. | 2012 | 22542760 | Tissue | Elav-Gal4 | Neuromuscular junction morphology | Fluorescence | VDRC | Selected genes | UAS-IR construct | Visual inspection | np | For further phenotype explanations sp. | GR00335-A | 43651 | FBgn0011739 | wts | JF02741 | np | none | | | | Germline stem cell (GSC) regulation | A Regulatory Network of Drosophila Germline Stem Cell Self-Renewal | Yan et al. | 2014 | 24576427 | Tissue | MTD-GAL4 or UAS-dcr2; nanos-GAL4 | Spectrin and vasa protein expression | Fluorescence | TRiP | Selected genes | UAS-IR construct | Visual inspection | np | More detailed phenotypes for some genes are shown in the comment. Various VALIUM vectors were used. | GR00335-A | 43651 | FBgn0011739 | wts | HMS00026 | np | none | | | | Germline stem cell (GSC) regulation | A Regulatory Network of Drosophila Germline Stem Cell Self-Renewal | Yan et al. | 2014 | 24576427 | Tissue | MTD-GAL4 or UAS-dcr2; nanos-GAL4 | Spectrin and vasa protein expression | Fluorescence | TRiP | Selected genes | UAS-IR construct | Visual inspection | np | More detailed phenotypes for some genes are shown in the comment. Various VALIUM vectors were used. | | 43651 | FBgn0011739 | np | np | sp | none | | | | | | | | | | | | | | | | | | | GR00367-S | 43651 | CG12072 | | 9928 | np | lethal or adult morphology phenotype | | | VDRC | Drosophila airway maturation | Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes | Hosono et al. | 2015 | 26551273 | Tissue | btl-GAL4 | Liquid clearance defect and viability | Visual inspection | VDRC, Trip, NIG | Genome-wide | UAS-IR construct | Frequency | >30% | | GR00370-A | 43651 | FBgn0011739 | wts | | 0.08 | none | | | | Regulation of Nrf2 homolog CncC | Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes | Li et al. | 2016 | 26911346 | Cell line | S2 | CncC reporter | Luminescence | HD2 | Kinases | dsRNA | Z-Score | <-1.65 OR >1.65 | | GR00370-A | 43651 | FBgn0011739 | wts | | 0.25 | none | | | | Regulation of Nrf2 homolog CncC | Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes | Li et al. | 2016 | 26911346 | Cell line | S2 | CncC reporter | Luminescence | HD2 | Kinases | dsRNA | Z-Score | <-1.65 OR >1.65 | | GR00370-A | 43651 | FBgn0011739 | wts | | -2.45 | Decreased CncC (Nrf2) reporter expression | | | | Regulation of Nrf2 homolog CncC | Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes | Li et al. | 2016 | 26911346 | Cell line | S2 | CncC reporter | Luminescence | HD2 | Kinases | dsRNA | Z-Score | <-1.65 OR >1.65 | | GR00379-A-1 | 43651 | CG12072 | | 106174 | -0.3008877462939108 | none | | | No phenotype in egg laying/hatching or larvae in egg laying or larvae | Stem cell maintenance | Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation | Sanchez et al. | 2016 | 26669894 | Organism | nanos-GAL4 | nos and yTub37c mRNA expression | qPCR | VDRC | Selected genes | UAS-IR construct | Z-score | Low: 1 - 2.5; Medium: 2.5 - 4; High: > | Selected genes are: transcriptome-wide in female Drosophila. Additional phenotypes (egg laying/hatching) noted in the comment section. Subset libraries from VDRC (KK or GD) can be found in a column next to the comment field. | GR00385-A | 43651 | | | 106174 | 0.1461361467189404 | Low performer in olfactory memory formation | | | Final hit | Regulation of olfactory memory formation | Identification of genes that promote or inhibit olfactory memory formation in Drosophila. | Walkinshaw et al. | 2015 | 25644700 | Organism | Nsyb-GAL4 | T-maze performance | Visual inspection | VDRC | Selected genes | UAS-IR construct | Performance index, sp | High performer in olfactory memory formation: > | Genes were preselected for relevance to CNS development and function using bioinformatic criteria. Additionally, defects in wing formation are considered in the comments column. We could not confirm the exact number of primary hits; however, final hits are noted in the comments field. | GR00388-A | 43651 | CG12072 | | BL27662 | | none | | | | Regulation of intestinal stem cells (ISC) | Genome-wide RNAi Screen Identifies Networks Involved in Intestinal Stem Cell Regulation in Drosophila | Zeng et al. | 2015 | 25704823 | Tissue | act5C-GAL4 | Viability | Visual inspection | VDRC and BDSC | Genome-wide | UAS-IR construct | np | np | Lethal transgenic lines identified from the primary screen were crossed with temperature-sensitive esg-GAL4 flies. Phenotypes of ISCs from the dissected midguts are shown in the "Comment" section. | GR00388-A | 43651 | CG12072 | | GD9928 | | none | | | | Regulation of intestinal stem cells (ISC) | Genome-wide RNAi Screen Identifies Networks Involved in Intestinal Stem Cell Regulation in Drosophila | Zeng et al. | 2015 | 25704823 | Tissue | act5C-GAL4 | Viability | Visual inspection | VDRC and BDSC | Genome-wide | UAS-IR construct | np | np | Lethal transgenic lines identified from the primary screen were crossed with temperature-sensitive esg-GAL4 flies. Phenotypes of ISCs from the dissected midguts are shown in the "Comment" section. | GR00388-A | 43651 | CG12072 | | BL34064 | | none | | | | Regulation of intestinal stem cells (ISC) | Genome-wide RNAi Screen Identifies Networks Involved in Intestinal Stem Cell Regulation in Drosophila | Zeng et al. | 2015 | 25704823 | Tissue | act5C-GAL4 | Viability | Visual inspection | VDRC and BDSC | Genome-wide | UAS-IR construct | np | np | Lethal transgenic lines identified from the primary screen were crossed with temperature-sensitive esg-GAL4 flies. Phenotypes of ISCs from the dissected midguts are shown in the "Comment" section. |