| GR00053-A | 128674 | NM_144733 | GPR73L1 | np | sp | Increased gamma-H2AX phosphorylation | | no | group 2 | Genome stability | A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. | Paulsen et al. | 2009 | 19647519 | Cell line | HeLa | gamma-H2AX phosphorylation and DNA content | Fluorescence | siARRAY human genome siRNA library | Genome-wide | siRNA | p-value | Complex criteria | Confidence groupings from 4 to 1 (highest level of confidence in group 4) | GR00054-A | 128674 | NM_144733 | GPR73L1 | np | 1.003 | none | | no | | Combinatorial effect with paclitaxel | Synthetic lethal screen identification of chemosensitizer loci in cancer cells. | Whitehurst et al. | 2007 | 17429401 | Cell line | NCI-H1155 | Viability (synthetic lethal) | ATP level | # G-005000-01 | Genome-wide | siRNA | Paclitaxel/control ratio | Complex criteria | Additional information about 87 high-confidence hits | GR00056-A | 128674 | NM_144733 | GPR73L1 | np | 0.986 | none | | no | | Melanogenesis | Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. | Ganesan et al. | 2008 | 19057677 | Cell line | MNT-1 | Melanin protein expression and viability | Absorbance and luminescence | rp | Genome-wide | siRNA | Normalized absorbance ratio | > 2 standard deviations below mean | Additional information about a secondary screen (retest to determine false-positive rate) | GR00057-A-1 | 128674 | NM_144733 | GPR73L1 | M-005594-01 | -0.78 | none | | no | | Wnt/beta-catenin pathway regulation (1) | A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. | Tang et al. | 2008 | 18621708 | Cell line | HeLa | Wnt pathway reporter | Luminescence | Human siArray siRNA library | Genome-wide | siRNA | Z-score | > 4 | Screen without Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries). | GR00057-A-2 | 128674 | NM_144733 | GPR73L1 | M-005594-01 | sp | none | | no | | Wnt/beta-catenin pathway regulation (2) | A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. | Tang et al. | 2008 | 18621708 | Cell line | HeLa | Wnt pathway reporter | Luminescence | Human siArray siRNA library | Genome-wide | siRNA | Complex, SP | Complex criteria | Screen with Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries). | GR00095-A | 128674 | NM_144773 | GPR73L1 | np | np | none | | | | p53 pathway components | A large-scale RNAi screen in human cells identifies new components of the p53 pathway | Berns et al. | 2004 | 15042092 | Cell line | BJ-TERT-tsLT fibroblasts | Proliferation | Colony-forming cell assay | Nki library | Genome-wide | shRNA | np | np | | GR00123-A | 128674 | NM_144773 | GPR73L1 | 130681, 130683, 130682 | np | none | | | | Combinatorial effect with nutlin-3 | An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors | Brummelkamp et al. | 2006 | 16474381 | Cell line | MCF-7 | Viability | Fluoresence | Nki library | Genome-wide | shRNA | log2 ratio | np | | GR00133-A-1 | 128674 | 128674 | GPR73L1 | np | -0.230774 | none | | no | | Salmonella enterica subspecies 1 serovar Typhimurium invasion (1) | RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42. | Misselwitz et al. | 2011 | 21407211 | Cell line | HeLa | Gentamycin protection invasion assay | Fluorescence | Druggable genome library V2.0 | Druggable genes | siRNA | log2 median | Complex criteria | | GR00149-A-1 | 128674 | 128674 | GPR73L1 | 6705 | 29.13 | none | | no | | Ciliogenesis and cilium length (1) | Functional genomic screen for modulators of ciliogenesis and cilium length. | Kim et al. | 2010 | 20393563 | Cell line | htRPE | Smoothed protein expression | Fluorescence | Human druggable genome siRNA library V3.1 | Druggable genes | siRNA | Normalized percent inhibition | > 1.5 OR < -1.5 standard deviations from mean | | GR00149-A-1 | 128674 | 128674 | GPR73L1 | 6705 | 33.46 | none | | no | | Ciliogenesis and cilium length (1) | Functional genomic screen for modulators of ciliogenesis and cilium length. | Kim et al. | 2010 | 20393563 | Cell line | htRPE | Smoothed protein expression | Fluorescence | Human druggable genome siRNA library V3.1 | Druggable genes | siRNA | Normalized percent inhibition | > 1.5 OR < -1.5 standard deviations from mean | | GR00149-A-1 | 128674 | 128674 | GPR73L1 | 46492 | -43.95 | none | | no | | Ciliogenesis and cilium length (1) | Functional genomic screen for modulators of ciliogenesis and cilium length. | Kim et al. | 2010 | 20393563 | Cell line | htRPE | Smoothed protein expression | Fluorescence | Human druggable genome siRNA library V3.1 | Druggable genes | siRNA | Normalized percent inhibition | > 1.5 OR < -1.5 standard deviations from mean | | GR00149-A-1 | 128674 | 128674 | GPR73L1 | 46492 | -9.56 | none | | no | | Ciliogenesis and cilium length (1) | Functional genomic screen for modulators of ciliogenesis and cilium length. | Kim et al. | 2010 | 20393563 | Cell line | htRPE | Smoothed protein expression | Fluorescence | Human druggable genome siRNA library V3.1 | Druggable genes | siRNA | Normalized percent inhibition | > 1.5 OR < -1.5 standard deviations from mean | | GR00149-A-1 | 128674 | 128674 | GPR73L1 | 129259 | -30.36 | none | | no | | Ciliogenesis and cilium length (1) | Functional genomic screen for modulators of ciliogenesis and cilium length. | Kim et al. | 2010 | 20393563 | Cell line | htRPE | Smoothed protein expression | Fluorescence | Human druggable genome siRNA library V3.1 | Druggable genes | siRNA | Normalized percent inhibition | > 1.5 OR < -1.5 standard deviations from mean | | GR00149-A-1 | 128674 | 128674 | GPR73L1 | 129259 | -16.84 | none | | no | | Ciliogenesis and cilium length (1) | Functional genomic screen for modulators of ciliogenesis and cilium length. | Kim et al. | 2010 | 20393563 | Cell line | htRPE | Smoothed protein expression | Fluorescence | Human druggable genome siRNA library V3.1 | Druggable genes | siRNA | Normalized percent inhibition | > 1.5 OR < -1.5 standard deviations from mean | | GR00165-A | 128674 | NM_144773 | PROKR2 | M-005594-01 | np | High actin ratio cells | | no | | HeLa cell morphology | Clustering phenotype populations by genome-wide RNAi and multiparametric imaging. | Fuchs et al. | 2010 | 20531400 | Cell line | HeLa | Cell morphology | Fluorescence | siGENOME | Genome-wide | siRNA | Complex, sp | np | | GR00180-A-1 | 128674 | 128674 | PROKR2 | PL-50004 | 0.497 | none | | no | | Hepatitis C virus replication (1) | A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. | Tai et al. | 2009 | 19286138 | Cell line | Huh7/Rep-Feo | HCV replicon RNA copy number | Luminescence | siARRAY Human Genome siRNA Library | Genome-wide | siRNA | q-value | Complex criteria | | GR00184-A-1 | 128674 | NM_144733 | PROKR2 | M-005594-01 | 0.36548793675068 | none | | no | | Self-renewal and pluripotency in human embryonic stem cells (1) | A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. | Chia et al. | 2010 | 20953172 | Cell line | hESC H1 | POU5F1 protein expression | Fluorescence | SMARTpool siRNA library | Genome-wide | siRNA | Z-score | < -2 | | GR00197-A-1 | 128674 | 128674 | PROKR2 | M-005594-01 | -0.801235757 | none | | no | | Human papillomavirus oncogene expression regulation (1) | Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. | Smith et al. | 2010 | 20133580 | Cell line | C33A/BE2/18LCR c4 | HPV18 LCR reporter activity | Luminescence | Human siGENOME SMARTpool library | Genome-wide | siRNA | Z-score | > | Author-submitted data. Phenotype strength according to Z-scores: weak: 2 - 3; moderate: 3 - 5; strong: > 5 | GR00236-A-1 | 128674 | 128674 | PROKR2 | M-005594-01 | 1.44638574057346 | none | | no | | Homologous recombination DNA double-strand break repair (HR-DSBR) (1) | A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. | Adamson et al. | 2012 | 22344029 | Cell line | DR-U2OS | (HR-DSBR) DR-GFP reporter and DNA content | Fluorescence | Human siGENOME siRNA (G-005000-05) | Genome-wide | siRNA | Relative HR ratio | < ~0.4 OR > 1.88 | Cutoff values correspond 2 standard deviations from the screen-wide mean | GR00240-S-1 | 128674 | NM_144733 | GPR73L1 | M-005594-01 | -0.23 | none | | yes | | TRAIL-induced apoptosis (1) | A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. | Kranz and Boutros | 2014 | 24442637 | Cell line | U251MG | Viability | Luminescence | SMART-pool siRNA | Genome-wide | siRNA | Z-score | > 4 | Author-submitted data | GR00240-S-2 | 128674 | NM_144733 | GPR73L1 | M-005594-01 | -0.34 | none | | no | Z-score -0.5695 | TRAIL-induced apoptosis (2) | A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. | Kranz and Boutros | 2014 | 24442637 | Cell line | U251MG | Viability (synthetic lethal) | Luminescence | SMART-pool siRNA | Genome-wide | siRNA | Differential score | > 3.6 AND viability Z-score < 4 | Author-submitted data. Z-scores from viability screen (1) are considered in score interpretation for this screen. | GR00242-A-1 | 128674 | NM_144733 | GPR73L1 | np | sp | none | | no | | Selective autophagy regulation (1) | Image-based genome-wide siRNA screen identifies selective autophagy factors. | Orvedahl et al. | 2011 | 22020285 | Cell line | HeLa/GFP-LC3 | Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression | Fluorescence | siGenome | Genome-wide | siRNA | Z-score | Complex criteria | | GR00247-A-1 | 128674 | | GPR73L1 | np | sp | none | | | rank: 9363 | Regulation of FOXO1 nuclear localization (1) | Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain. | Senapedis et al. | 2011 | 21460183 | Cell line | U2OS | EGFP-FOXO1a protein expression and DNA content | Fluorescence | Human Genome library | Genome-wide | siRNA | Complex, sp | Complex criteria | | GR00249-S | 128674 | 128674 | GPR73L1 | J-005594-09 | 0.05818 | none | | no | number of cells compared to control (%): 53.75 | Vaccinia virus (VACV) infection | Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan et al. | 2013 | 23401514 | Cell line | HeLa | Vaccinia virus VACV IHD-J/GFP protein expression and DNA content | Fluorescence | Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus | Genome-wide | siRNA | Z-score | > | Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. | GR00249-S | 128674 | 128674 | GPR73L1 | M-005594-01 | -1.10055 | none | | no | number of cells compared to control (%): 66.12 | Vaccinia virus (VACV) infection | Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan et al. | 2013 | 23401514 | Cell line | HeLa | Vaccinia virus VACV IHD-J/GFP protein expression and DNA content | Fluorescence | Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus | Genome-wide | siRNA | Z-score | > | Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. | GR00249-S | 128674 | 128674 | PROKR2 | s43338 | -0.68674 | none | | no | number of cells compared to control (%): 80.79 | Vaccinia virus (VACV) infection | Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan et al. | 2013 | 23401514 | Cell line | HeLa | Vaccinia virus VACV IHD-J/GFP protein expression and DNA content | Fluorescence | Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus | Genome-wide | siRNA | Z-score | > | Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. | GR00249-S | 128674 | 128674 | PROKR2 | s43339 | -0.18164 | none | | no | number of cells compared to control (%): 77.79 | Vaccinia virus (VACV) infection | Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan et al. | 2013 | 23401514 | Cell line | HeLa | Vaccinia virus VACV IHD-J/GFP protein expression and DNA content | Fluorescence | Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus | Genome-wide | siRNA | Z-score | > | Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. | GR00249-S | 128674 | 128674 | PROKR2 | s43340 | 0.83769 | none | | no | number of cells compared to control (%): 88.79 | Vaccinia virus (VACV) infection | Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan et al. | 2013 | 23401514 | Cell line | HeLa | Vaccinia virus VACV IHD-J/GFP protein expression and DNA content | Fluorescence | Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus | Genome-wide | siRNA | Z-score | > | Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. | GR00253-A | 128674 | NM_144733 | GPR73L1 | np | -1.532 | Decreased hepcidin::fluc mRNA expression | | | | hepcidin regulation | Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. | Mleczko-Sanecka et al. | 2014 | 24385536 | Cell line | Huh7 | hepcidin::fluc mRNA expression | Luminescence | siGenome siARRAY SMARTpool | Genome-wide | siRNA | Z-score | > | Cutoff < | GR00255-A-1 | 128674 | 128674 | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008913, TRCN0000008914, TRCN0000008915 | -0.096813543 | none | | | | Negative genetic interactions (1) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.0 | HCT116 BLM-/- and HCT116 BLM+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-2 | 128674 | 128674 | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008913, TRCN0000008914, TRCN0000008915 | 0.136939118 | none | | | | Negative genetic interactions (2) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.0 | HCT116 MUS81-/- and HCT116 MUS81+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-3 | 128674 | 128674 | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008913, TRCN0000008914, TRCN0000008915 | -0.176091404 | none | | | | Negative genetic interactions (3) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.2 | HCT116 PTEN-/- and HCT116 PTEN+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-4 | 128674 | 128674 | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008913, TRCN0000008914, TRCN0000008915 | -0.407097744 | none | | | | Negative genetic interactions (4) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.2 | HCT116 PTTG1-/- and HCT116 PTTG1+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-5 | 128674 | 128674 | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008913, TRCN0000008914, TRCN0000008915 | 0.190246076 | none | | | | Negative genetic interactions (5) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -0.8 | HCT116 KRASG13D/- and HCT116 KRAS+/- cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00293-A | 128674 | | GPR73L1 | np | 0.246 | none | | | | Combinatorial effect with paclitaxel | Mechanisms Promoting Escape from Mitotic Stress−Induced Tumor Cell Death | Sinnott et al. | 2014 | 24860162 | Cell line | HCC366 | Viability | Luminescence | Thermo-Fisher | Genome-wide | siRNA | Z-score | < -2.5 | Final hits according to the author are indicated in the comment. | GR00300-A | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915, TRCN0000008913, TRCN0000008914 | 0 | none | | | | Combinatorial effect with RAF inhibitor PLX4720 | A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition. | Whittaker et al. | 2013 | 23288408 | Cell line | A375 | shRNA abundance | Sequencing | TRC | Genome-wide | shRNA | Number of shRNAs ranked Top1000 | > 2 | The A375 cell line used here harbours the BRAF V600E mutation and is therefore sensitive to RAF inhibitors. | GR00303-A | 128674 | NM_144733 | GPR73L1 | np | -0.05 | none | | | | Clear cell renal cell carcinoma (ccRCC) survival regulation | Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target | Gerlinger et al. | 2012 | 22362593 | Cell line | VHL-deficient RCC4 | Proliferation and Viability | Fluorescence | np | Genome-wide | siRNA | Z-score | < | In the phenotype data duplicates were in the original document, which have been removed. | GR00310-A-1 | 128674 | 128674 | GPR73L1 | np | -1.21 | none | | | | Sindbis virus (SINV) infection (1) | Genome-Wide RNAi Screen Identifies Novel Host Proteins Required for Alphavirus Entry | Ooi et al. | 2013 | 24367265 | Cell line | U2OS | Sindbis virus (SINV) reporter | Luminescence | Ambion Silencer V3 | Genome-wide | siRNA | Z-score | < -3 OR > 2 | | | 128674 | 128674 | PROKR2 | np | 45.4 | none | | | 112,8% viability | | | | | | | | | | | | | | | | GR00313-A | 128674 | NM_144773 | PROKR2 | np | -0.57 | none | | | | TNF-alpha pathway regulation | A Genome-Wide RNA Interference Screen Identifies Caspase 4 as a Factor Required for Tumor Necrosis Factor Alpha Signaling. | Nickles et al. | 2012 | 22733992 | Cell line | HEK293T | NFkappaB pathway reporter | Luminescence | Qiagen | Genome-wide | siRNA | Z-score | < | Additional filters were a reduction in firefly luciferase levels by at least 50% compared to the mean of the experiment and a concomitant reduction of renilla luciferase expression of not more than 30%. | GR00318-A | 128674 | 128674 | GPR73L1 | np | 0.704 | none | | | siRNA set: gPCR | Huntingtin toxicity | A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington’s Disease | Miller et al. | 2012 | 23209424 | Cell line | HEK293T | Caspase 3/7 activity | Fluorescence | Dharmacon | Selected genes | siRNA | Sum of normalized caspase 3/7 activity mean and standard error | < 0.683 | HEK293T cells were cotransfected with mutant Huntingtin fused to GFP (Htt1-558141Q-GFP). | GR00327-A | 128674 | 3733 | GCH1 | CLL-H-011155 | 0.2437929467083754 | none | | | | Tumor formation | An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation | Wolf et al. | 2013 | 24292671 | Cell line | SUM-149 | shRNA abundance | Next-generation sequencing | Decipher library module 1 | Selected genes | shRNA | Z-score | > 2.24 | Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. | GR00327-A | 128674 | 3733 | GCH1 | CLL-H-011154 | -0.1500051881199001 | none | | | | Tumor formation | An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation | Wolf et al. | 2013 | 24292671 | Cell line | SUM-149 | shRNA abundance | Next-generation sequencing | Decipher library module 1 | Selected genes | shRNA | Z-score | > 2.24 | Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. | GR00327-A | 128674 | 3733 | GCH1 | CLL-H-011156 | np | none | | | | Tumor formation | An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation | Wolf et al. | 2013 | 24292671 | Cell line | SUM-149 | shRNA abundance | Next-generation sequencing | Decipher library module 1 | Selected genes | shRNA | Z-score | > 2.24 | Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. | GR00327-A | 128674 | 3733 | GCH1 | CLL-H-011158 | 0.06158840061353567 | none | | | | Tumor formation | An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation | Wolf et al. | 2013 | 24292671 | Cell line | SUM-149 | shRNA abundance | Next-generation sequencing | Decipher library module 1 | Selected genes | shRNA | Z-score | > 2.24 | Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. | GR00327-A | 128674 | 3733 | GCH1 | CLL-H-011157 | -0.026088079460492113 | none | | | | Tumor formation | An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation | Wolf et al. | 2013 | 24292671 | Cell line | SUM-149 | shRNA abundance | Next-generation sequencing | Decipher library module 1 | Selected genes | shRNA | Z-score | > 2.24 | Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. | GR00343-S | 128674 | 128674 | PROKR2 | TRCN0000008913 | -0.20500000000000007 | none | | | | Lentiviral shRNA "Achilles Heel" screen | Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia | Cole et al. | 2015 | 26058080 | Cell line | K562 | shRNA abundance | Fluorescence | Lentiviral shRNA library | Genome-wide | shRNA | Log2 ratio | < | Comparison of day 21 vs. day 0 abundance data | GR00343-S | 128674 | 128674 | PROKR2 | TRCN0000008915 | 0.682500000000001 | none | | | | Lentiviral shRNA "Achilles Heel" screen | Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia | Cole et al. | 2015 | 26058080 | Cell line | K562 | shRNA abundance | Fluorescence | Lentiviral shRNA library | Genome-wide | shRNA | Log2 ratio | < | Comparison of day 21 vs. day 0 abundance data | GR00343-S | 128674 | 128674 | PROKR2 | TRCN0000008914 | 1.7075000000000005 | none | | | | Lentiviral shRNA "Achilles Heel" screen | Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia | Cole et al. | 2015 | 26058080 | Cell line | K562 | shRNA abundance | Fluorescence | Lentiviral shRNA library | Genome-wide | shRNA | Log2 ratio | < | Comparison of day 21 vs. day 0 abundance data | GR00343-S | 128674 | 128674 | PROKR2 | TRCN0000008912 | -0.057500000000000995 | none | | | | Lentiviral shRNA "Achilles Heel" screen | Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia | Cole et al. | 2015 | 26058080 | Cell line | K562 | shRNA abundance | Fluorescence | Lentiviral shRNA library | Genome-wide | shRNA | Log2 ratio | < | Comparison of day 21 vs. day 0 abundance data | GR00343-S | 128674 | 128674 | PROKR2 | TRCN0000008911 | 0.22749999999999915 | none | | | | Lentiviral shRNA "Achilles Heel" screen | Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia | Cole et al. | 2015 | 26058080 | Cell line | K562 | shRNA abundance | Fluorescence | Lentiviral shRNA library | Genome-wide | shRNA | Log2 ratio | < | Comparison of day 21 vs. day 0 abundance data | GR00359-A | 128674 | 128674 | GPR73L1 | M-005594-01 | -2.295545423022114 | Weakly decreased NFAT1-GFP nuclear translocation | | | | NFAT activation | An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry | Sharma et al. | 2013 | 23792561 | Cell line | HeLa | NFAT1-GFP nuclear translocation | Fluorescence | Dharmacon siGENOME | Genome-wide | siRNA | Z-score | Strong: < | HeLa cells stably expressed NFAT1-GFP. Libraries were Dharmacon siGENOME v2007 and v2010 | GR00363-A | 128674 | 128674 | PROKR2 | 6705, SI03081351, SI00152726, 6797, SI00152733, 46492, SI03028256 | sp | Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis | | | strong | Endocytosis regulation | Systems survey of endocytosis by multiparametric image analysis. | Collinet et al. | 2010 | 20190736 | Cell line | HeLa | Transferrin (TF) and epidermal growth factor (EGF) subcellular localisation, DNA content | Fluorescence | Ambion, Qiagen and esiRNA library (Kittler et al.) | Genome-wide | siRNA | Complex, sp | Complex criteria | Two hit categories: "strong" (maximum of Prob Chi2, Prob Chi2 EGF, Prob Chi2 Tfn > 0.95) and "weak but specific" (maximum of Prob Chi2, Prob Chi2 EGF, Prob Chi2 Tfn < 0.95 but Phenoscore > 0.95). Additional information about secondary screens with kinase and phospatase libraries. | GR00366-A-1 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.147864548222023 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (1) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | 22RV1_PROSTATE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-10 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.650610977316343 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (10) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | ACHN_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-100 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.271664616475444 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (100) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LAMA84_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-101 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.433732281763457 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (101) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LK2_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-102 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.368166467679993 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (102) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN215_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-103 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.361168849235704 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (103) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN229_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-104 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.806688134376445 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (104) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN235_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-105 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.663076050838501 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (105) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN319_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-106 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.318428087889198 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (106) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN340_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-107 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.533993586466805 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (107) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN382_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-108 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.742923180507134 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (108) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN428_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-109 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.234950204056957 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (109) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN443_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-11 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.176282947006561 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (11) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | AGS_STOMACH | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-110 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.293000112602779 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (110) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN464_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-111 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.565386525904903 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (111) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LNZ308_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-112 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.32655753418391 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (112) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LOVO_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-113 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.0508039873076966 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (113) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LS411N_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-114 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.247641910407585 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (114) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LS513_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-115 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -1.03980705155136 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (115) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MCF7_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-116 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.307854309304485 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (116) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MDAMB453_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-117 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.908254508418018 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (117) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MIAPACA2_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-118 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.0505197882063795 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (118) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MKN7_STOMACH | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-119 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.0434082495490037 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (119) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-12 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.598924990363563 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (12) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | AM38_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-120 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.491357123436324 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (120) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-121 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -1.24425162604745 | Decreased shRNA abundance (Z-score < -2) | | | PROKR2_1_10011 | Context-specific genetic dependencies (121) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-122 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.90980304719721 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (122) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MONOMAC6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-123 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.698776102017926 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (123) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MV411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-124 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.081312260921243 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (124) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-125 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.083133646884322 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (125) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-126 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.206542021021572 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (126) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1299_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-127 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.0366297830175261 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (127) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1437_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-128 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.0104476950597927 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (128) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1650_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-129 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.264319765167167 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (129) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1792_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-13 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.455568156743635 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (13) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | AML193_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-130 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.036554484095197 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (130) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH196_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-131 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.0183038862686947 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (131) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1975_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-132 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.261304436416341 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (132) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH2052_PLEURA | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-133 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.480851002534752 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (133) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH2122_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-134 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.891097783545127 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (134) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH2171_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-135 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.126948320927506 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (135) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH23_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-136 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.443226826132535 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (136) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH2452_PLEURA | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-137 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.522390079405055 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (137) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH441_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-138 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.318091590730517 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (138) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH508_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-139 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.153187167219189 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (139) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH660_PROSTATE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-14 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.461772150148297 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (14) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | ASPC1_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-140 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.0840140706965414 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (140) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH661_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-141 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.0392284392066277 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (141) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH716_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-142 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.506830900908524 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (142) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH838_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-143 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.509169776052091 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (143) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIN87_STOMACH | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-144 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.395777519861351 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (144) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NIHOVCAR3_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-145 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.424488880978771 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (145) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NOMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-146 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.315288812268405 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (146) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OAW42_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-147 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.671712306493408 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (147) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-148 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.0432108315985042 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (148) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-149 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.367286092520264 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (149) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-15 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.769505239822554 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (15) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | BT20_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-150 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.685802133647293 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (150) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OE33_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-151 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.0366821581191597 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (151) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OELE_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-152 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.160545504747217 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (152) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-153 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.866361354418644 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (153) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OV7_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-154 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.772922963019614 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (154) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OV90_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-155 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 1.72860664978727 | Increased shRNA abundance (Z-score > 2) | | | PROKR2_1_10011 | Context-specific genetic dependencies (155) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OVCAR4_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-156 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.865373292914418 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (156) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OVCAR8_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-157 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.703291040731995 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (157) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OVISE_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-158 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.288184231024285 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (158) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PANC0327_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-159 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.386181763064969 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (159) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PANC0813_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-16 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.223401398245064 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (16) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | BT474_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-160 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.642735481389243 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (160) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PANC1005_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-161 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.353529783284173 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (161) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PLB985_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-162 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 1.0396342874288 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (162) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PSN1_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-163 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.261260923519552 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (163) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | QGP1_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-164 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.227140941629168 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (164) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-165 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.551287305891577 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (165) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RKN_SOFT_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-166 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.739876566912505 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (166) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RKO_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-167 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.686951233078617 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (167) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RMGI_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-168 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.0931486168008826 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (168) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RMUGS_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-169 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.303166493692082 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (169) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-17 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.0236803906223324 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (17) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | BXPC3_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-170 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.712982942492765 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (170) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RT112_URINARY_TRACT | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-171 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.326545919898307 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (171) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-172 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.339551501548621 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (172) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SF126_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-173 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.446414919355652 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (173) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SF172_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-174 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.0262854151095625 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (174) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SF295_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-175 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.129366120680245 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (175) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SF767_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-176 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.674491551828336 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (176) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SJSA1_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-177 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.620443434334772 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (177) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKCO1_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-178 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -1.07464726078959 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (178) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKMEL5_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-179 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.368744203374256 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (179) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKMM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-18 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.214900024142057 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (18) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | C2BBE1_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-180 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.776044914744446 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (180) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKNO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-181 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.0458533833744471 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (181) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKOV3_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-182 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.470744848079915 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (182) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKRC20_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-183 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.560984950962245 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (183) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR20_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-184 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.634887825492367 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (184) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR21_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-185 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.0161438555222473 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (185) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR23_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-186 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.510336514194586 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (186) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR24_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-187 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 1.40555028704118 | Increased shRNA abundance (Z-score > 2) | | | PROKR2_1_10011 | Context-specific genetic dependencies (187) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR25_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-188 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.438723297297891 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (188) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR26_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-189 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.510597634703464 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (189) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SNU1105_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-19 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.0277285509566556 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (19) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | C32_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-190 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.077880013436049 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (190) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SNU840_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-191 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.167505826322322 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (191) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SNUC1_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-192 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.00101254417518567 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (192) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SNUC2A_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-193 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.297353158854727 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (193) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SU8686_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-194 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.735015808475356 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (194) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SW1417_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-195 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.275609174420555 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (195) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SW1783_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-196 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.12098497646131 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (196) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SW480_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-197 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.568089731949133 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (197) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SW48_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-198 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.873631088698199 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (198) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | T98G_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-199 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -1.13221514057029 | Decreased shRNA abundance (Z-score < -2) | | | PROKR2_1_10011 | Context-specific genetic dependencies (199) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TC71_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-2 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.42040245005948 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (2) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | 697_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-20 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -1.07486936236982 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (20) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CADOES1_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-200 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.426477472243252 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (200) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TCCSUP_URINARY_TRACT | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-201 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.170885527231648 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (201) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TE10_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-202 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.480660842332393 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (202) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TE15_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-203 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.809231368391582 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (203) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TE9_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-204 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.500296964258735 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (204) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-205 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.0594768353666654 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (205) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TOV112D_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-206 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.540433264502363 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (206) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TOV21G_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-207 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.0122519680705709 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (207) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TT_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-208 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.153700735620421 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (208) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TYKNU_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-209 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.283242522329905 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (209) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | U178_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-21 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.379709684655542 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (21) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAL120_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-210 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.605946925905963 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (210) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | U251MG_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-211 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.675393634675969 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (211) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | U343_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-212 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.188995695205004 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (212) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | U87MG_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-213 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.00745818532208237 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (213) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | UOK101_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-214 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.501403837821195 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (214) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | VCAP_PROSTATE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-215 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.163486816872033 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (215) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | YKG1_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-216 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.246774328945478 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (216) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | ZR7530_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-22 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 1.56434352772985 | Increased shRNA abundance (Z-score > 2) | | | PROKR2_1_10011 | Context-specific genetic dependencies (22) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAL51_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-23 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.697854143941516 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (23) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CALU1_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-24 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 1.15415668609267 | Increased shRNA abundance (Z-score > 2) | | | PROKR2_1_10011 | Context-specific genetic dependencies (24) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAOV3_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-25 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.367112767030475 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (25) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAOV4_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-26 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.538770039466314 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (26) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAS1_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-27 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.550050315069317 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (27) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CFPAC1_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-28 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.368802692382949 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (28) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CH157MN_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-29 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.171667353998177 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (29) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COLO205_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-3 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.617260584997711 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (3) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | 786O_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-30 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.53121165927432 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (30) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COLO704_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-31 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.708629159627976 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (31) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COLO741_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-32 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.908737460463447 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (32) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COLO783_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-33 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 1.18386042227846 | Increased shRNA abundance (Z-score > 2) | | | PROKR2_1_10011 | Context-specific genetic dependencies (33) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CORL23_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-34 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.231691047832121 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (34) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COV362_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-35 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.437193734132447 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (35) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COV434_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-36 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.512918489043994 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (36) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COV504_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-37 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.059995252266261 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (37) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COV644_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-38 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.81042551882726 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (38) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | DBTRG05MG_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-39 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.382209842534068 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (39) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | DKMG_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-4 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.0144828469415134 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (4) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A1207_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-40 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.13201407681592 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (40) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | DLD1_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-41 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.695286772862343 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (41) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EFE184_ENDOMETRIUM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-42 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.15481029698011 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (42) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EFM19_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-43 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.948230276197291 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (43) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EFO21_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-44 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.652689238307362 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (44) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EFO27_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-45 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -1.04517395577623 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (45) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EW8_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-46 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.0131666546248427 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (46) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EWS502_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-47 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.00168236631391043 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (47) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | F36P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-48 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 1.42575860871095 | Increased shRNA abundance (Z-score > 2) | | | PROKR2_1_10011 | Context-specific genetic dependencies (48) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | GB1_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-49 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.590482283109254 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (49) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | GP2D_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-5 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.0334814532448558 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (5) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A172_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-50 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.658729235104054 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (50) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC1187_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-51 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.172528118769961 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (51) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC1395_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-52 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.139682411366687 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (52) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC1954_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-53 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.548143276922176 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (53) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC2218_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-54 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.296030201913808 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (54) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC2814_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-55 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.177423940417997 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (55) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC364_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-56 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.2928619069866 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (56) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC44_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-57 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.419528095596896 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (57) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC70_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-58 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.383623469844792 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (58) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC827GR5_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-59 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.583471248393656 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (59) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC827_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-6 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.540057796746551 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (6) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A204_SOFT_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-60 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.110513551156013 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (60) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCT116_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-61 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 1.10106560816421 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (61) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HEC1A_ENDOMETRIUM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-62 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.627111282755293 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (62) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HEYA8_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-63 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.51359882129393 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (63) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-64 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.573186946142303 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (64) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HLF_LIVER | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-65 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.667686227921731 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (65) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HNT34_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-66 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.154679173319546 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (66) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HPAC_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-67 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 1.36846399355061 | Increased shRNA abundance (Z-score > 2) | | | PROKR2_1_10011 | Context-specific genetic dependencies (67) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HPAFII_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-68 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.259425393985088 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (68) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HS683_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-69 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.0270206378384992 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (69) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HS766T_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-7 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.303055861657948 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (7) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A2058_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-70 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.0186719964515207 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (70) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HS944T_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-71 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.535035840599114 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (71) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HT1197_URINARY_TRACT | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-72 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.563131436889404 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (72) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HT29_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-73 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.79033273083076 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (73) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HT55_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-74 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.390920232653256 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (74) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HUG1N_STOMACH | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-75 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.444194514392795 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (75) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HUTU80_SMALL_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-76 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.000318673022113667 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (76) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | IGR39_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-77 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.567972692531434 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (77) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | IGROV1_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-78 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.0891501012446311 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (78) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | IOMMLEE_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-79 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.190255570120813 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (79) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | JHESOAD1_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-8 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.413101662898467 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (8) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A549_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-80 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.0354333148972171 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (80) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | JHOC5_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-81 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.858040800952893 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (81) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | JHOM1_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-82 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.123825752728671 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (82) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-83 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.629280309503843 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (83) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-84 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.279641472655541 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (84) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KALS1_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-85 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -1.13984044910502 | Decreased shRNA abundance (Z-score < -2) | | | PROKR2_1_10011 | Context-specific genetic dependencies (85) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-86 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.28464415163857 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (86) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KM12_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-87 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.167685541448685 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (87) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-88 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.501363126833792 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (88) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KNS60_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-89 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.656176209611757 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (89) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KNS81_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-9 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.12419387114597 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (9) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A673_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-90 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.253037786398474 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (90) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KP1NL_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-91 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.325509945109443 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (91) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KP2_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-92 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.504656263141051 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (92) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KP4_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-93 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 1.28162849507743 | Increased shRNA abundance (Z-score > 2) | | | PROKR2_1_10011 | Context-specific genetic dependencies (93) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KURAMOCHI_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-94 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.741925148979156 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (94) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KYSE150_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-95 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.148502525342797 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (95) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KYSE30_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-96 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.502269361000036 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (96) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KYSE450_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-97 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.531091074502129 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (97) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KYSE510_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-98 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | -0.495466600812252 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (98) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | L33_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-99 | 128674 | | PROKR2 | TRCN0000008911, TRCN0000008912, TRCN0000008915 | 0.724372824276392 | none | | | PROKR2_1_10011 | Context-specific genetic dependencies (99) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00368-A | 128674 | 128674 | PROKR2 | | 0.84 | Decreased viability ratio | | | wt viability: 1 | Combinatorial effect with E-Cadherin | Synthetic Lethal Screens Identify Vulnerabilities in GPCR Signaling and Cytoskeletal Organization in E-Cadherin–Deficient Cells | Telford et al. | 2015 | 25777964 | Cell line | MCF10A | Viability (synthetic lethal) | Luminescence | Dharmacon | Genome-wide | siRNA | CDH1(-/-)/wt viability ratio | < | MCF10A wild type viability higher-or-equal to 50% was considered as additional cutoff (values noted in "comment" section). | | 128674 | 128674 | PROKR2 | | 0.02 | none | | | | | | | | | | | | | | | | | | | GR00371-A-1 | 128674 | 128674 | GPR73L1 | | 0.951235302653 | none | | | Dharmacon | Nanog expression in absence of bFGF and TGFbeta | Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways | Gonzales et al. | 2015 | 26232226 | Cell line | NANOG-GFP H1 hESC | NANOG expression | Fluorescence | Dharmacon and Ambion | Selected genes | siRNA | Z-score | >1,25 OR >1,5 [in at least two replicates] | Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted. | GR00371-A-2 | 128674 | GPR73L1 | 128674 | | -0.130627292591 | none | | | Dharmacon | Nanog expression in presence of TGFbeta inhibitor | Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways | Gonzales et al. | 2015 | 26232226 | Cell line | NANOG-GFP H1 hESC | NANOG expression | Fluorescence | Dharmacon and Ambion | Selected genes | siRNA | Z-score | >1,25 OR >1,5 [in at least two replicates] | Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted. | GR00371-A-3 | 128674 | 128674 | GPR73L1 | | 0.96602847236 | none | | | Dharmacon | Nanog expression in presence of MEK inhibitor | Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways | Gonzales et al. | 2015 | 26232226 | Cell line | NANOG-GFP H1 hESC | NANOG expression | Fluorescence | Dharmacon and Ambion | Selected genes | siRNA | Z-score | >1,25 OR >1,5 [in at least two replicates] | Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted. | GR00371-A-4 | 128674 | 128674 | GPR73L1 | | 0.195458352314 | none | | | Dharmacon | Nanog expression in presence of PI3K inhibitor | Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways | Gonzales et al. | 2015 | 26232226 | Cell line | NANOG-GFP H1 hESC | NANOG expression | Fluorescence | Dharmacon and Ambion | Selected genes | siRNA | Z-score | >1,25 OR >1,5 [in at least two replicates] | Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted. | GR00371-A-5 | 128674 | 128674 | GPR73L1 | | 1.76089797765 | none | | | Dharmacon | Nanog expression in presence of retinoic acid | Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways | Gonzales et al. | 2015 | 26232226 | Cell line | NANOG-GFP H1 hESC | NANOG expression | Fluorescence | Dharmacon and Ambion | Selected genes | siRNA | Z-score | >1,25 OR >1,5 [in at least two replicates] | Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted. | GR00376-A-1 | 128674 | 128674 | PROKR2 | | 0.80227176 | none | | | | Mitigators of SS1P-induced immunotoxicity | Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity | Pasetto et al. | 2015 | 25713356 | Cell line | KB cells | Viability | Luminescence | Ambion Silencer Select Version 4 | Genome-wide | siRNA | RSA P-value | <0.001 | SS1P was applied in a "high dose", ≈EC90, 13 ng/ml. Cutoff was derived from data submitted to Pubchem (ID 1117281). Reagent sequences but no ID | GR00376-A-2 | 128674 | 128674 | PROKR2 | | 0.01419565 | none | | | | Sensitizers of SS1P-induced immunotoxicity | Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity | Pasetto et al. | 2015 | 25713356 | Cell line | KB cells | Viability | Luminescence | Ambion Silencer Select Version 4 | Genome-wide | siRNA | RSA P-value | <0.001 | SS1P was applied in a "low dose", ≈EC30, 3 ng/ml. Cutoff was derived from data submitted to PubChem (ID 1117281). Reagent sequences but no ID | GR00378-A | 128674 | | GPR73L1 | | -0.620851265 | none | | | | Poliovirus vaccine production | Engineering Enhanced Vaccine Cell Lines To Eradicate Vaccine-Preventable Diseases: the Polio End Game | van der Sanden et al. | 2015 | 26581994 | Cell line | HEp-2C | Infection with Attenuated Poliovirus | ELISA | Dharmacon | Genome-wide | siRNA | Z-score | > | For infection, a single lot of the attenuated Sabin type 2 poliovirus was used for the screen. Gene IDs were not provided, only the gene name/symbol | GR00386-A-1 | 128674 | 128674 | PROKR2 | | 99.1622269517831 | none | | | | NOD2 stimulation by MDP | A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. | Warner et al. | 2014 | 25170077 | Cell line | HEK293 stably expressing NOD2 | Viability | Luminescence | Dharmacon | Genome-wide | siRNA | Percentage growth | Decreased: <70, increased: >120 | Reagent IDs not provided | GR00386-A-2 | 128674 | 128674 | PROKR2 | | 40.3 | none | | | | MDP-induced IL-8 secretion | A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. | Warner et al. | 2014 | 25170077 | Cell line | HEK293 stably expressing NOD2 | IL-8 secretion | ELISA | Dharmacon | Genome-wide | siRNA | Percent inhibition of IL-8 secretion | Increased: <-300, Decreased: >60 | Concentration of IL-8 was measured from cell supernatants by sandwich ELISA. IL-8 values (pg/ml) were normalized to IL-8 secreted in cells treated with RIPK2-specific siRNA (100% inhibition) and non-targeting siRNA (0% inhibition). Secondary validating screen assessed 554 genes whose silencing affected MDP-induced IL-8 secretion in the primary screen. Final validated IL-8 regulators (positive or negative) are listed in the comments column. Reagent IDs not provided |