| GR00053-A | 2036 | NM_012156 | EPB41L1 | np | sp | none | | no | | Genome stability | A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. | Paulsen et al. | 2009 | 19647519 | Cell line | HeLa | gamma-H2AX phosphorylation and DNA content | Fluorescence | siARRAY human genome siRNA library | Genome-wide | siRNA | p-value | Complex criteria | Confidence groupings from 4 to 1 (highest level of confidence in group 4) | GR00054-A | 2036 | NM_012156 | EPB41L1 | np | 0.896 | none | | no | | Combinatorial effect with paclitaxel | Synthetic lethal screen identification of chemosensitizer loci in cancer cells. | Whitehurst et al. | 2007 | 17429401 | Cell line | NCI-H1155 | Viability (synthetic lethal) | ATP level | # G-005000-01 | Genome-wide | siRNA | Paclitaxel/control ratio | Complex criteria | Additional information about 87 high-confidence hits | GR00056-A | 2036 | NM_012156 | EPB41L1 | np | 1.044 | none | | no | | Melanogenesis | Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. | Ganesan et al. | 2008 | 19057677 | Cell line | MNT-1 | Melanin protein expression and viability | Absorbance and luminescence | rp | Genome-wide | siRNA | Normalized absorbance ratio | > 2 standard deviations below mean | Additional information about a secondary screen (retest to determine false-positive rate) | GR00057-A-1 | 2036 | NM_012156 | EPB41L1 | M-019042-00 | -0.88 | none | | no | | Wnt/beta-catenin pathway regulation (1) | A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. | Tang et al. | 2008 | 18621708 | Cell line | HeLa | Wnt pathway reporter | Luminescence | Human siArray siRNA library | Genome-wide | siRNA | Z-score | > 4 | Screen without Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries). | GR00057-A-2 | 2036 | NM_012156 | EPB41L1 | M-019042-00 | sp | none | | no | | Wnt/beta-catenin pathway regulation (2) | A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. | Tang et al. | 2008 | 18621708 | Cell line | HeLa | Wnt pathway reporter | Luminescence | Human siArray siRNA library | Genome-wide | siRNA | Complex, SP | Complex criteria | Screen with Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries). | GR00095-A | 2036 | AB002336 | EPB41L1 | np | np | none | | | | p53 pathway components | A large-scale RNAi screen in human cells identifies new components of the p53 pathway | Berns et al. | 2004 | 15042092 | Cell line | BJ-TERT-tsLT fibroblasts | Proliferation | Colony-forming cell assay | Nki library | Genome-wide | shRNA | np | np | | GR00123-A | 2036 | AB002336 | EPB41L1 | 142263, 142262, 142261 | np | none | | | | Combinatorial effect with nutlin-3 | An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors | Brummelkamp et al. | 2006 | 16474381 | Cell line | MCF-7 | Viability | Fluoresence | Nki library | Genome-wide | shRNA | log2 ratio | np | | GR00133-A-1 | 2036 | 2036 | EPB41L1 | np | -0.677753 | Decreased Salmonella enterica Typhimurium invasion | | yes | with and without Z-score correction | Salmonella enterica subspecies 1 serovar Typhimurium invasion (1) | RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42. | Misselwitz et al. | 2011 | 21407211 | Cell line | HeLa | Gentamycin protection invasion assay | Fluorescence | Druggable genome library V2.0 | Druggable genes | siRNA | log2 median | Complex criteria | | GR00133-A-2 | 2036 | 2036 | EPB41L1 | Hs_EPB41L1_1, Hs_EPB41L1_2, Hs_EPB41L1_5, Hs_EPB41L1_7 | -0.175369337782012 | none | | yes | | Salmonella enterica subspecies 1 serovar Typhimurium invasion (2) | RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42. | Misselwitz et al. | 2011 | 21407211 | Cell line | HeLa | Gentamycin protection invasion assay | Fluorescence | Druggable genome library V2.0 | Selected genes | siRNA | log2 median | > | | GR00133-A-3 | 2036 | 2036 | EPB41L1 | Hs_EPB41L1_1, Hs_EPB41L1_2, Hs_EPB41L1_5, Hs_EPB41L1_7 | -0.268874345145653 | none | | yes | | Salmonella enterica subspecies 1 serovar Typhimurium invasion (3) | RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42. | Misselwitz et al. | 2011 | 21407211 | Cell line | HeLa | LPS protein expression binding assay | Fluorescence | Druggable genome library V2.0 | Selected genes | siRNA | log2 median | > | | GR00133-A-5 | 2036 | 2036 | EPB41L1 | Hs_EPB41L1_1, Hs_EPB41L1_2, Hs_EPB41L1_5, Hs_EPB41L1_7 | -0.0178833395231775 | none | | no | | Salmonella enterica subspecies 1 serovar Typhimurium invasion (5) | RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42. | Misselwitz et al. | 2011 | 21407211 | Cell line | HeLa | Cell morphology ruffling assay | Fluorescence, automated | Druggable genome library V2.0 | Selected genes | siRNA | log2 median | > | | GR00151-A-1 | 2036 | ENSG00000088367 | EPB41L1 | np | -0.507 | none | | no | | Homologous recombination DNA double-strand break repair (HR-DSBR) (1) | A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. | Słabicki et al. | 2010 | 20613862 | Cell line | HeLa | (HR-DSBR) DR-GFP reporter | Flow cytometry | Custom-made | Genome-wide | esiRNA | Z-score | < -2 OR > 2 | | GR00180-A-1 | 2036 | 2036 | EPB41L1 | PL-50019 | 0.884 | none | | no | | Hepatitis C virus replication (1) | A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. | Tai et al. | 2009 | 19286138 | Cell line | Huh7/Rep-Feo | HCV replicon RNA copy number | Luminescence | siARRAY Human Genome siRNA Library | Genome-wide | siRNA | q-value | Complex criteria | | GR00184-A-1 | 2036 | NM_012156 | EPB41L1 | M-019042-00 | -0.863799907882607 | none | | no | | Self-renewal and pluripotency in human embryonic stem cells (1) | A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. | Chia et al. | 2010 | 20953172 | Cell line | hESC H1 | POU5F1 protein expression | Fluorescence | SMARTpool siRNA library | Genome-wide | siRNA | Z-score | < -2 | | GR00197-A-1 | 2036 | 2036 | EPB41L1 | M-019042-00 | -0.539768721 | none | | no | | Human papillomavirus oncogene expression regulation (1) | Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. | Smith et al. | 2010 | 20133580 | Cell line | C33A/BE2/18LCR c4 | HPV18 LCR reporter activity | Luminescence | Human siGENOME SMARTpool library | Genome-wide | siRNA | Z-score | > | Author-submitted data. Phenotype strength according to Z-scores: weak: 2 - 3; moderate: 3 - 5; strong: > 5 | | 2036 | | EPB41L1 | np | np | Decreased viability in non-small-cell lung cancer (NSCLC) lineage | | no | NSCLC: no filter, 2nd best | | | | | | | | | | | | | | | | GR00236-A-1 | 2036 | 2036 | EPB41L1 | M-019042-00 | 1.51625179730084 | none | | no | | Homologous recombination DNA double-strand break repair (HR-DSBR) (1) | A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. | Adamson et al. | 2012 | 22344029 | Cell line | DR-U2OS | (HR-DSBR) DR-GFP reporter and DNA content | Fluorescence | Human siGENOME siRNA (G-005000-05) | Genome-wide | siRNA | Relative HR ratio | < ~0.4 OR > 1.88 | Cutoff values correspond 2 standard deviations from the screen-wide mean | GR00240-S-1 | 2036 | NM_012156 | EPB41L1 | M-019042-00 | 0.31 | none | | yes | | TRAIL-induced apoptosis (1) | A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. | Kranz and Boutros | 2014 | 24442637 | Cell line | U251MG | Viability | Luminescence | SMART-pool siRNA | Genome-wide | siRNA | Z-score | > 4 | Author-submitted data | GR00240-S-2 | 2036 | NM_012156 | EPB41L1 | M-019042-00 | -0.53 | none | | no | Z-score -0.248 | TRAIL-induced apoptosis (2) | A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. | Kranz and Boutros | 2014 | 24442637 | Cell line | U251MG | Viability (synthetic lethal) | Luminescence | SMART-pool siRNA | Genome-wide | siRNA | Differential score | > 3.6 AND viability Z-score < 4 | Author-submitted data. Z-scores from viability screen (1) are considered in score interpretation for this screen. | GR00242-A-1 | 2036 | NM_012156 | EPB41L1 | np | sp | none | | no | | Selective autophagy regulation (1) | Image-based genome-wide siRNA screen identifies selective autophagy factors. | Orvedahl et al. | 2011 | 22020285 | Cell line | HeLa/GFP-LC3 | Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression | Fluorescence | siGenome | Genome-wide | siRNA | Z-score | Complex criteria | | GR00247-A-1 | 2036 | | EPB41L1 | np | sp | none | | | rank: 11196 | Regulation of FOXO1 nuclear localization (1) | Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain. | Senapedis et al. | 2011 | 21460183 | Cell line | U2OS | EGFP-FOXO1a protein expression and DNA content | Fluorescence | Human Genome library | Genome-wide | siRNA | Complex, sp | Complex criteria | | GR00249-S | 2036 | 2036 | EPB41L1 | J-019042-05 | -0.14053 | none | | no | number of cells compared to control (%): 82.57 | Vaccinia virus (VACV) infection | Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan et al. | 2013 | 23401514 | Cell line | HeLa | Vaccinia virus VACV IHD-J/GFP protein expression and DNA content | Fluorescence | Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus | Genome-wide | siRNA | Z-score | > | Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. | GR00249-S | 2036 | 2036 | EPB41L1 | M-019042-00 | 1.18951 | Increased vaccinia virus (VACV) infection | | no | number of cells compared to control (%): 56.97 | Vaccinia virus (VACV) infection | Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan et al. | 2013 | 23401514 | Cell line | HeLa | Vaccinia virus VACV IHD-J/GFP protein expression and DNA content | Fluorescence | Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus | Genome-wide | siRNA | Z-score | > | Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. | GR00249-S | 2036 | 2036 | EPB41L1 | s4704 | -0.66225 | none | | no | number of cells compared to control (%): 93.26 | Vaccinia virus (VACV) infection | Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan et al. | 2013 | 23401514 | Cell line | HeLa | Vaccinia virus VACV IHD-J/GFP protein expression and DNA content | Fluorescence | Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus | Genome-wide | siRNA | Z-score | > | Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. | GR00249-S | 2036 | 2036 | EPB41L1 | s4705 | -0.48457 | none | | no | number of cells compared to control (%): 95.64 | Vaccinia virus (VACV) infection | Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan et al. | 2013 | 23401514 | Cell line | HeLa | Vaccinia virus VACV IHD-J/GFP protein expression and DNA content | Fluorescence | Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus | Genome-wide | siRNA | Z-score | > | Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. | GR00249-S | 2036 | 2036 | EPB41L1 | s4706 | 0.21112 | none | | no | number of cells compared to control (%): 71.44 | Vaccinia virus (VACV) infection | Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan et al. | 2013 | 23401514 | Cell line | HeLa | Vaccinia virus VACV IHD-J/GFP protein expression and DNA content | Fluorescence | Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus | Genome-wide | siRNA | Z-score | > | Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. | GR00253-A | 2036 | NM_012156 | EPB41L1 | np | -0.987 | none | | | | hepcidin regulation | Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. | Mleczko-Sanecka et al. | 2014 | 24385536 | Cell line | Huh7 | hepcidin::fluc mRNA expression | Luminescence | siGenome siARRAY SMARTpool | Genome-wide | siRNA | Z-score | > | Cutoff < | GR00255-A-1 | 2036 | 2036 | EPB41L1 | TRCN0000116472, TRCN0000116473, TRCN0000116474, TRCN0000116475, TRCN0000116476 | 1.203528392 | none | | | | Negative genetic interactions (1) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.0 | HCT116 BLM-/- and HCT116 BLM+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-2 | 2036 | 2036 | EPB41L1 | TRCN0000116472, TRCN0000116473, TRCN0000116474, TRCN0000116475, TRCN0000116476 | 0.327578512 | none | | | | Negative genetic interactions (2) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.0 | HCT116 MUS81-/- and HCT116 MUS81+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-3 | 2036 | 2036 | EPB41L1 | TRCN0000116472, TRCN0000116473, TRCN0000116474, TRCN0000116475, TRCN0000116476 | 0.580724354 | none | | | | Negative genetic interactions (3) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.2 | HCT116 PTEN-/- and HCT116 PTEN+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-4 | 2036 | 2036 | EPB41L1 | TRCN0000116472, TRCN0000116473, TRCN0000116474, TRCN0000116475, TRCN0000116476 | 1.934503422 | none | | | | Negative genetic interactions (4) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.2 | HCT116 PTTG1-/- and HCT116 PTTG1+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-5 | 2036 | 2036 | EPB41L1 | TRCN0000116472, TRCN0000116473, TRCN0000116474, TRCN0000116475, TRCN0000116476 | -1.0744947 | Negative genetic interaction between KRASG13D/+ and KRAS+/- | | | | Negative genetic interactions (5) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -0.8 | HCT116 KRASG13D/- and HCT116 KRAS+/- cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00293-A | 2036 | | EPB41L1 | np | -0.373 | none | | | | Combinatorial effect with paclitaxel | Mechanisms Promoting Escape from Mitotic Stress−Induced Tumor Cell Death | Sinnott et al. | 2014 | 24860162 | Cell line | HCC366 | Viability | Luminescence | Thermo-Fisher | Genome-wide | siRNA | Z-score | < -2.5 | Final hits according to the author are indicated in the comment. | GR00300-A | 2036 | | EPB41L1 | TRCN0000116472, TRCN0000116473, TRCN0000116474, TRCN0000116475, TRCN0000116476 | 0 | none | | | | Combinatorial effect with RAF inhibitor PLX4720 | A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition. | Whittaker et al. | 2013 | 23288408 | Cell line | A375 | shRNA abundance | Sequencing | TRC | Genome-wide | shRNA | Number of shRNAs ranked Top1000 | > 2 | The A375 cell line used here harbours the BRAF V600E mutation and is therefore sensitive to RAF inhibitors. | GR00303-A | 2036 | NM_012156 | EPB41L1 | np | -0.02 | none | | | | Clear cell renal cell carcinoma (ccRCC) survival regulation | Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target | Gerlinger et al. | 2012 | 22362593 | Cell line | VHL-deficient RCC4 | Proliferation and Viability | Fluorescence | np | Genome-wide | siRNA | Z-score | < | In the phenotype data duplicates were in the original document, which have been removed. | GR00310-A-1 | 2036 | 2036 | EPB41L1 | np | -0.42 | none | | | | Sindbis virus (SINV) infection (1) | Genome-Wide RNAi Screen Identifies Novel Host Proteins Required for Alphavirus Entry | Ooi et al. | 2013 | 24367265 | Cell line | U2OS | Sindbis virus (SINV) reporter | Luminescence | Ambion Silencer V3 | Genome-wide | siRNA | Z-score | < -3 OR > 2 | | | 2036 | 2036 | EPB41L1 | np | 72.5 | Decreased NF-kappaB reporter expression | | | 79.7% viability; included in validation screen | | | | | | | | | | | | | | | | GR00313-A | 2036 | NM_012156, NM_177996 | EPB41L1 | np | 0.5 | none | | | | TNF-alpha pathway regulation | A Genome-Wide RNA Interference Screen Identifies Caspase 4 as a Factor Required for Tumor Necrosis Factor Alpha Signaling. | Nickles et al. | 2012 | 22733992 | Cell line | HEK293T | NFkappaB pathway reporter | Luminescence | Qiagen | Genome-wide | siRNA | Z-score | < | Additional filters were a reduction in firefly luciferase levels by at least 50% compared to the mean of the experiment and a concomitant reduction of renilla luciferase expression of not more than 30%. | GR00318-A | 2036 | 2036 | EPB41L1 | np | 1.044 | none | | | siRNA set: druggable genome | Huntingtin toxicity | A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington’s Disease | Miller et al. | 2012 | 23209424 | Cell line | HEK293T | Caspase 3/7 activity | Fluorescence | Dharmacon | Selected genes | siRNA | Sum of normalized caspase 3/7 activity mean and standard error | < 0.683 | HEK293T cells were cotransfected with mutant Huntingtin fused to GFP (Htt1-558141Q-GFP). | GR00327-A | 2036 | 2036 | SULT2B1 | CLL-H-024936 | 0.0971070941986919 | none | | | | Tumor formation | An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation | Wolf et al. | 2013 | 24292671 | Cell line | SUM-149 | shRNA abundance | Next-generation sequencing | Decipher library module 1 | Selected genes | shRNA | Z-score | > 2.24 | Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. | GR00327-A | 2036 | 2036 | SULT2B1 | CLL-H-024938 | -0.8227392596420474 | none | | | | Tumor formation | An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation | Wolf et al. | 2013 | 24292671 | Cell line | SUM-149 | shRNA abundance | Next-generation sequencing | Decipher library module 1 | Selected genes | shRNA | Z-score | > 2.24 | Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. | GR00327-A | 2036 | 2036 | SULT2B1 | CLL-H-024937 | np | none | | | | Tumor formation | An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation | Wolf et al. | 2013 | 24292671 | Cell line | SUM-149 | shRNA abundance | Next-generation sequencing | Decipher library module 1 | Selected genes | shRNA | Z-score | > 2.24 | Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. | GR00327-A | 2036 | 2036 | SULT2B1 | CLL-H-024935 | -0.1890035968631027 | none | | | | Tumor formation | An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation | Wolf et al. | 2013 | 24292671 | Cell line | SUM-149 | shRNA abundance | Next-generation sequencing | Decipher library module 1 | Selected genes | shRNA | Z-score | > 2.24 | Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. | GR00327-A | 2036 | 2036 | SULT2B1 | CLL-H-024934 | -0.5004551488528615 | none | | | | Tumor formation | An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation | Wolf et al. | 2013 | 24292671 | Cell line | SUM-149 | shRNA abundance | Next-generation sequencing | Decipher library module 1 | Selected genes | shRNA | Z-score | > 2.24 | Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. | GR00327-A | 2036 | 2036 | SULT2B1 | CLL-H-024933 | 1.0381004887113912 | none | | | | Tumor formation | An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation | Wolf et al. | 2013 | 24292671 | Cell line | SUM-149 | shRNA abundance | Next-generation sequencing | Decipher library module 1 | Selected genes | shRNA | Z-score | > 2.24 | Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. | GR00360-A-1 | 2036 | ENSG00000088367 | EPB41L1 | 243774 | 0.7605333333333331 | Mildly decreased CFP-tsO45G cell surface transport | | | | Secretory transport (1) | Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway | Simpson et al. | 2012 | 22660414 | Cell line | HeLa Kyoto | CFP-tsO45G cell surface transport | Fluorescence | Ambion | Genome-wide | siRNA | Deviation score | < - 1 OR > 0.75 (mild: 0.75 - 1.0; strong: > 1.0) | For validation screen see Secretory transport (2). | GR00363-A | 2036 | 2036 | EPB41L1 | SI00097566, 243773, 243774, SI00160489, SI00097573, SI02639014 | sp | Decreased transferrin (TF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region) | | | strong | Endocytosis regulation | Systems survey of endocytosis by multiparametric image analysis. | Collinet et al. | 2010 | 20190736 | Cell line | HeLa | Transferrin (TF) and epidermal growth factor (EGF) subcellular localisation, DNA content | Fluorescence | Ambion, Qiagen and esiRNA library (Kittler et al.) | Genome-wide | siRNA | Complex, sp | Complex criteria | Two hit categories: "strong" (maximum of Prob Chi2, Prob Chi2 EGF, Prob Chi2 Tfn > 0.95) and "weak but specific" (maximum of Prob Chi2, Prob Chi2 EGF, Prob Chi2 Tfn < 0.95 but Phenoscore > 0.95). Additional information about secondary screens with kinase and phospatase libraries. | GR00366-A-1 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.872053697854587 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (1) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | 22RV1_PROSTATE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-10 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.530491489434467 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (10) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | ACHN_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-100 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.10309318521538 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (100) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LAMA84_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-101 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.294395070645119 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (101) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LK2_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-102 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.728487384583439 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (102) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN215_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-103 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.05593761781194 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (103) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN229_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-104 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.29607763327541 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (104) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN235_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-105 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.321149313431699 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (105) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN319_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-106 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.758360568292979 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (106) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN340_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-107 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.143189297081232 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (107) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN382_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-108 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 1.67138654236531 | Increased shRNA abundance (Z-score > 2) | | | EPB41L1_1_10101 | Context-specific genetic dependencies (108) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN428_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-109 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -1.03989692068562 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (109) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN443_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-11 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.710226947433108 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (11) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | AGS_STOMACH | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-110 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.8346190798256 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (110) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN464_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-111 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.287210986949501 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (111) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LNZ308_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-112 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 1.55187397963158 | Increased shRNA abundance (Z-score > 2) | | | EPB41L1_1_10101 | Context-specific genetic dependencies (112) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LOVO_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-113 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.258577089428464 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (113) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LS411N_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-114 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -1.07830192148286 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (114) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LS513_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-115 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 1.23624478495162 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (115) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MCF7_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-116 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.405685080090304 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (116) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MDAMB453_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-117 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.991682979347624 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (117) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MIAPACA2_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-118 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.476211732631925 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (118) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MKN7_STOMACH | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-119 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.253622364214234 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (119) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-12 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.404225312534636 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (12) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | AM38_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-120 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.0770942649485907 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (120) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-121 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 1.4992851368131 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (121) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-122 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.0459716567718654 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (122) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MONOMAC6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-123 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.735835771371979 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (123) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MV411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-124 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.537015541075063 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (124) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-125 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.0825976345840158 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (125) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-126 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.312443051141932 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (126) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1299_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-127 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.962017395346729 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (127) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1437_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-128 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -1.26622759151371 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (128) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1650_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-129 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.682770097007987 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (129) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1792_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-13 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.308481043908492 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (13) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | AML193_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-130 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -1.47100146181288 | Decreased shRNA abundance (Z-score < -2) | | | EPB41L1_1_10101 | Context-specific genetic dependencies (130) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH196_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-131 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.0243106108247706 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (131) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1975_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-132 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.998052444422387 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (132) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH2052_PLEURA | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-133 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 1.44146083655624 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (133) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH2122_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-134 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.102430707484934 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (134) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH2171_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-135 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.382999781486925 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (135) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH23_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-136 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.579958553588249 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (136) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH2452_PLEURA | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-137 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.737871486615013 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (137) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH441_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-138 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.634439705909577 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (138) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH508_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-139 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.248456609590277 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (139) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH660_PROSTATE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-14 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.26888331468235 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (14) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | ASPC1_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-140 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -1.03762508934007 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (140) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH661_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-141 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.38117368052427 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (141) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH716_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-142 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.0688406741765417 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (142) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH838_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-143 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 1.97248634053006 | Increased shRNA abundance (Z-score > 2) | | | EPB41L1_1_10101 | Context-specific genetic dependencies (143) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIN87_STOMACH | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-144 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.669862629776788 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (144) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NIHOVCAR3_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-145 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.335738252830379 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (145) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NOMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-146 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 1.97950263894985 | Increased shRNA abundance (Z-score > 2) | | | EPB41L1_1_10101 | Context-specific genetic dependencies (146) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OAW42_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-147 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.0497343182438013 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (147) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-148 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.0449583559217188 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (148) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-149 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 1.29984203753254 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (149) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-15 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.603606009052743 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (15) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | BT20_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-150 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.269464409777197 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (150) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OE33_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-151 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.977131005865476 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (151) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OELE_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-152 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.0766529796285165 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (152) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-153 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.57626030312365 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (153) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OV7_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-154 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.376918500925733 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (154) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OV90_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-155 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.0966721196414292 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (155) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OVCAR4_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-156 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.0567602849058455 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (156) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OVCAR8_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-157 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 1.51783919319459 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (157) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OVISE_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-158 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 1.03265631631247 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (158) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PANC0327_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-159 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.474963060173755 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (159) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PANC0813_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-16 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.0479799398990157 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (16) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | BT474_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-160 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.95014123945108 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (160) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PANC1005_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-161 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.577291890724938 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (161) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PLB985_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-162 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.457987287910308 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (162) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PSN1_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-163 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.149261630198681 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (163) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | QGP1_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-164 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.537528398660226 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (164) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-165 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.147749345201687 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (165) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RKN_SOFT_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-166 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 1.88269330763626 | Increased shRNA abundance (Z-score > 2) | | | EPB41L1_1_10101 | Context-specific genetic dependencies (166) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RKO_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-167 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.286461489333857 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (167) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RMGI_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-168 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.256950211568125 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (168) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RMUGS_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-169 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.444139012977682 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (169) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-17 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.366100375389122 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (17) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | BXPC3_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-170 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.546044893211764 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (170) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RT112_URINARY_TRACT | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-171 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.0730104030718279 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (171) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-172 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.350931317716729 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (172) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SF126_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-173 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.21702417961562 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (173) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SF172_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-174 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -1.32744550133666 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (174) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SF295_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-175 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.165848906390205 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (175) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SF767_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-176 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.928921426371935 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (176) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SJSA1_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-177 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -1.29275484643685 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (177) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKCO1_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-178 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.0686888888534554 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (178) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKMEL5_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-179 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.528655295983974 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (179) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKMM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-18 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.182903357633075 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (18) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | C2BBE1_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-180 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.0583150400366182 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (180) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKNO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-181 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.329676955972382 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (181) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKOV3_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-182 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.793119675742721 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (182) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKRC20_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-183 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.733616577489134 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (183) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR20_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-184 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.13909925116386 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (184) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR21_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-185 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.951121792308982 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (185) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR23_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-186 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.119391775760641 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (186) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR24_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-187 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.36396264186697 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (187) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR25_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-188 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.528111043655376 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (188) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR26_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-189 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.588951351041436 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (189) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SNU1105_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-19 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.147186995363308 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (19) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | C32_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-190 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.521764297220087 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (190) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SNU840_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-191 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.372665774497888 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (191) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SNUC1_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-192 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.112472867740857 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (192) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SNUC2A_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-193 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.306693337814389 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (193) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SU8686_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-194 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.60554076710996 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (194) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SW1417_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-195 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -1.18091558391015 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (195) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SW1783_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-196 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 1.5767980664017 | Increased shRNA abundance (Z-score > 2) | | | EPB41L1_1_10101 | Context-specific genetic dependencies (196) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SW480_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-197 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.536871942306235 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (197) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SW48_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-198 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.890519431365154 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (198) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | T98G_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-199 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.0860809147307932 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (199) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TC71_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-2 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.312531439191115 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (2) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | 697_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-20 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.115877892979993 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (20) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CADOES1_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-200 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.516516104463717 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (200) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TCCSUP_URINARY_TRACT | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-201 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.320005444066752 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (201) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TE10_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-202 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.907218499349918 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (202) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TE15_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-203 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.206338680665937 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (203) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TE9_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-204 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.464553736227838 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (204) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-205 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.0184036826894063 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (205) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TOV112D_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-206 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.334236708856618 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (206) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TOV21G_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-207 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.201422275681839 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (207) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TT_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-208 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -1.28069114467024 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (208) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TYKNU_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-209 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.726845061562393 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (209) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | U178_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-21 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.388674583591399 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (21) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAL120_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-210 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.401936815916444 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (210) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | U251MG_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-211 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.796330545291277 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (211) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | U343_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-212 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -1.0506759966861 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (212) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | U87MG_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-213 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.42579320299262 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (213) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | UOK101_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-214 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.82628785828494 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (214) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | VCAP_PROSTATE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-215 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.376017585009057 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (215) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | YKG1_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-216 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.618179333887955 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (216) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | ZR7530_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-22 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.582743534467831 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (22) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAL51_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-23 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.542406812205845 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (23) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CALU1_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-24 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.514363914995136 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (24) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAOV3_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-25 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.334541149492519 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (25) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAOV4_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-26 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.0237497078963602 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (26) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAS1_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-27 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.106748268154158 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (27) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CFPAC1_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-28 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.498950851476801 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (28) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CH157MN_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-29 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.923256570285631 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (29) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COLO205_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-3 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.534813543735658 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (3) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | 786O_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-30 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 1.08186534763233 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (30) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COLO704_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-31 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.343662400810578 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (31) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COLO741_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-32 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.74486407200014 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (32) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COLO783_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-33 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -1.27833304727416 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (33) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CORL23_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-34 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.592056327496355 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (34) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COV362_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-35 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.36285779078187 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (35) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COV434_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-36 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.877866749834342 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (36) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COV504_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-37 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.700899049341059 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (37) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COV644_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-38 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.69014743908355 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (38) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | DBTRG05MG_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-39 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.0394685752940904 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (39) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | DKMG_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-4 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.380599791219009 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (4) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A1207_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-40 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.227342835998877 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (40) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | DLD1_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-41 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.599140955634319 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (41) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EFE184_ENDOMETRIUM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-42 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.987774759493209 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (42) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EFM19_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-43 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.397888019595582 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (43) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EFO21_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-44 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.213611986518429 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (44) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EFO27_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-45 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.234225699368807 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (45) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EW8_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-46 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.417875407323711 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (46) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EWS502_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-47 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.279764939875246 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (47) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | F36P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-48 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 1.02722956668407 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (48) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | GB1_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-49 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.200386381489813 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (49) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | GP2D_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-5 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.2545584941605 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (5) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A172_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-50 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.0898986948353056 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (50) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC1187_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-51 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.713485400169609 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (51) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC1395_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-52 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.548506241269146 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (52) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC1954_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-53 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 1.12146331780639 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (53) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC2218_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-54 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.604724761700068 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (54) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC2814_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-55 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -1.69580284370711 | Decreased shRNA abundance (Z-score < -2) | | | EPB41L1_1_10101 | Context-specific genetic dependencies (55) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC364_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-56 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.0701952742123517 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (56) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC44_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-57 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 1.0447535147978 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (57) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC70_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-58 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.647941492959847 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (58) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC827GR5_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-59 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.361834431514792 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (59) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC827_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-6 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.719729902198806 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (6) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A204_SOFT_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-60 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 1.68695738922569 | Increased shRNA abundance (Z-score > 2) | | | EPB41L1_1_10101 | Context-specific genetic dependencies (60) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCT116_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-61 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.507223490708538 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (61) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HEC1A_ENDOMETRIUM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-62 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.424338317340122 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (62) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HEYA8_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-63 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -1.32733904950639 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (63) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-64 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.721905151315474 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (64) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HLF_LIVER | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-65 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.525252962479447 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (65) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HNT34_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-66 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.660864198338687 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (66) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HPAC_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-67 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.0113686385694211 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (67) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HPAFII_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-68 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.846186116754269 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (68) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HS683_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-69 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.591037491161989 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (69) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HS766T_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-7 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.376278757179188 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (7) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A2058_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-70 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.256649417267157 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (70) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HS944T_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-71 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -1.15935279519654 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (71) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HT1197_URINARY_TRACT | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-72 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.647224821013323 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (72) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HT29_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-73 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.429410204385367 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (73) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HT55_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-74 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 1.02110095707046 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (74) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HUG1N_STOMACH | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-75 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.35541792302895 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (75) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HUTU80_SMALL_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-76 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.696455907908328 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (76) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | IGR39_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-77 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 1.21525386087009 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (77) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | IGROV1_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-78 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.25981533086508 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (78) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | IOMMLEE_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-79 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.424271536663916 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (79) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | JHESOAD1_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-8 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.176456989645214 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (8) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A549_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-80 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.489206076203146 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (80) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | JHOC5_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-81 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.323220540317641 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (81) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | JHOM1_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-82 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.8151272812736 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (82) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-83 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.568457776933535 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (83) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-84 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.971718823554697 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (84) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KALS1_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-85 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 1.55198125927813 | Increased shRNA abundance (Z-score > 2) | | | EPB41L1_1_10101 | Context-specific genetic dependencies (85) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-86 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.134742857400711 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (86) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KM12_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-87 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 1.85209317567315 | Increased shRNA abundance (Z-score > 2) | | | EPB41L1_1_10101 | Context-specific genetic dependencies (87) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-88 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.358513067647622 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (88) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KNS60_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-89 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.872930733105265 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (89) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KNS81_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-9 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.734137317798604 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (9) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A673_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-90 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -1.1193075030979 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (90) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KP1NL_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-91 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.448934802783744 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (91) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KP2_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-92 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.311006685742884 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (92) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KP4_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-93 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.571058125125457 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (93) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KURAMOCHI_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-94 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -1.19361923925406 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (94) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KYSE150_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-95 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.488105782306455 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (95) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KYSE30_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-96 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | -0.502250270928764 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (96) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KYSE450_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-97 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.487270513003866 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (97) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KYSE510_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-98 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 0.410343008254489 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (98) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | L33_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-99 | 2036 | | EPB41L1 | TRCN0000116476, TRCN0000287064, TRCN0000287065 | 1.26448098208242 | none | | | EPB41L1_1_10101 | Context-specific genetic dependencies (99) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | | 2036 | 2036 | EPB41L1 | | -0.07 | none | | | | | | | | | | | | | | | | | | | GR00376-A-1 | 2036 | 2036 | EPB41L1 | | 0.18477516 | none | | | | Mitigators of SS1P-induced immunotoxicity | Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity | Pasetto et al. | 2015 | 25713356 | Cell line | KB cells | Viability | Luminescence | Ambion Silencer Select Version 4 | Genome-wide | siRNA | RSA P-value | <0.001 | SS1P was applied in a "high dose", ≈EC90, 13 ng/ml. Cutoff was derived from data submitted to Pubchem (ID 1117281). Reagent sequences but no ID | GR00376-A-2 | 2036 | 2036 | EPB41L1 | | 0.367825485 | none | | | | Sensitizers of SS1P-induced immunotoxicity | Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity | Pasetto et al. | 2015 | 25713356 | Cell line | KB cells | Viability | Luminescence | Ambion Silencer Select Version 4 | Genome-wide | siRNA | RSA P-value | <0.001 | SS1P was applied in a "low dose", ≈EC30, 3 ng/ml. Cutoff was derived from data submitted to PubChem (ID 1117281). Reagent sequences but no ID | GR00378-A | 2036 | | EPB41L1 | | 1.183080696 | none | | | | Poliovirus vaccine production | Engineering Enhanced Vaccine Cell Lines To Eradicate Vaccine-Preventable Diseases: the Polio End Game | van der Sanden et al. | 2015 | 26581994 | Cell line | HEp-2C | Infection with Attenuated Poliovirus | ELISA | Dharmacon | Genome-wide | siRNA | Z-score | > | For infection, a single lot of the attenuated Sabin type 2 poliovirus was used for the screen. Gene IDs were not provided, only the gene name/symbol | | 2036 | NM_012156 | EPB41L1 | | 45.943 | none | | | | | | | | | | | | | | | | | | | GR00386-A-1 | 2036 | 2036 | EPB41L1 | | 76.7887661759617 | none | | | | NOD2 stimulation by MDP | A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. | Warner et al. | 2014 | 25170077 | Cell line | HEK293 stably expressing NOD2 | Viability | Luminescence | Dharmacon | Genome-wide | siRNA | Percentage growth | Decreased: <70, increased: >120 | Reagent IDs not provided | GR00386-A-2 | 2036 | 2036 | EPB41L1 | | 48.4 | none | | | | MDP-induced IL-8 secretion | A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. | Warner et al. | 2014 | 25170077 | Cell line | HEK293 stably expressing NOD2 | IL-8 secretion | ELISA | Dharmacon | Genome-wide | siRNA | Percent inhibition of IL-8 secretion | Increased: <-300, Decreased: >60 | Concentration of IL-8 was measured from cell supernatants by sandwich ELISA. IL-8 values (pg/ml) were normalized to IL-8 secreted in cells treated with RIPK2-specific siRNA (100% inhibition) and non-targeting siRNA (0% inhibition). Secondary validating screen assessed 554 genes whose silencing affected MDP-induced IL-8 secretion in the primary screen. Final validated IL-8 regulators (positive or negative) are listed in the comments column. Reagent IDs not provided |