GR00098-A-1 | 375133 | ENSG00000183506 | LOC220686 | ENSG00000183506 | sp | none | | no | | Cell division (1) | Genome-scale RNAi profiling of cell division in human tissue culture cells. | Kittler et al. | 2007 | 17994010 | Cell line | HeLa | Cell number and DNA content | Laser scanning cytometry | rp | Genome-wide | esiRNA | Complex, sp | Complex criteria | | GR00151-A-1 | 375133 | ENSG00000183506 | PI1KAP2 | np | -0.601 | none | | no | | Homologous recombination DNA double-strand break repair (HR-DSBR) (1) | A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. | Słabicki et al. | 2010 | 20613862 | Cell line | HeLa | (HR-DSBR) DR-GFP reporter | Flow cytometry | Custom-made | Genome-wide | esiRNA | Z-score | < -2 OR > 2 | | GR00180-A-1 | 375133 | 375133 | PI4KAP2 | PL-50080 | 1.27e-05 | Decreased Hepatitis C virus replication | | yes | | Hepatitis C virus replication (1) | A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. | Tai et al. | 2009 | 19286138 | Cell line | Huh7/Rep-Feo | HCV replicon RNA copy number | Luminescence | siARRAY Human Genome siRNA Library | Genome-wide | siRNA | q-value | Complex criteria | | GR00180-A-2 | 375133 | 375133 | PI4KAP2 | np | np | none | | no | | Hepatitis C virus replication (2) | A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. | Tai et al. | 2009 | 19286138 | Cell line | Huh7/Rep-Feo | HCV replicon RNA copy number | Luminescence | siARRAY Human Genome siRNA Library | Selected genes | siRNA | Number of positive siRNA | > | | GR00196-A-1 | 375133 | ENSG00000183506 | | np | sp | none | | no | | TP53 interactions (1) | A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly. | Krastev et al. | 2011 | 21642980 | Cell line | HCT116 ( wildtype and TP53 knockout) | TP53 protein expression and viability | Fluorescence | rp | Genome-wide | esiRNA | Complex, sp | Complex criteria | | | 375133 | | PI4KAP2 | np | np | Decreased viability in pancreas lineage | | no | pancreas: no filter, KS | | | | | | | | | | | | | | | | GR00249-S | 375133 | 375133 | LOC375133 | J-032119-05 | 0.91605 | none | | no | number of cells compared to control (%): 89.02 | Vaccinia virus (VACV) infection | Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan et al. | 2013 | 23401514 | Cell line | HeLa | Vaccinia virus VACV IHD-J/GFP protein expression and DNA content | Fluorescence | Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus | Genome-wide | siRNA | Z-score | > | Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. | GR00249-S | 375133 | 375133 | LOC375133 | s200610 | 1.21237 | Increased vaccinia virus (VACV) infection | | no | number of cells compared to control (%): 82.06 | Vaccinia virus (VACV) infection | Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan et al. | 2013 | 23401514 | Cell line | HeLa | Vaccinia virus VACV IHD-J/GFP protein expression and DNA content | Fluorescence | Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus | Genome-wide | siRNA | Z-score | > | Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. | | 375133 | 375133 | PI4KAP2 | np | 63.9 | Inconclusive | | | 57,8% viability | | | | | | | | | | | | | | | | GR00366-A-1 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.29495802365117 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (1) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | 22RV1_PROSTATE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-10 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.0152700432405503 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (10) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | ACHN_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-100 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.75596638067575 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (100) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LAMA84_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-101 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.309388593866956 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (101) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LK2_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-102 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.156785144614833 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (102) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN215_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-103 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.55295309814378 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (103) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN229_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-104 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.742833726460519 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (104) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN235_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-105 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.05962327292848 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (105) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN319_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-106 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.0307890519787673 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (106) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN340_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-107 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.703923355645252 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (107) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN382_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-108 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.04450068738503 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (108) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN428_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-109 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.0159584996532632 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (109) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN443_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-11 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -2.01089972099916 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (11) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | AGS_STOMACH | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-110 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.163274341711512 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (110) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN464_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-111 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.85154558764109 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (111) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LNZ308_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-112 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.334761207712388 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (112) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LOVO_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-113 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.54275347828 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (113) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LS411N_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-114 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.266244146717298 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (114) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LS513_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-115 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.659596385750834 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (115) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MCF7_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-116 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.612833360329428 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (116) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MDAMB453_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-117 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.235194472862772 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (117) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MIAPACA2_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-118 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.08804419404357 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (118) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MKN7_STOMACH | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-119 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.662868049524612 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (119) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-12 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.537555535660023 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (12) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | AM38_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-120 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.213783509764987 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (120) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-121 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.444779562857084 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (121) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-122 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 2.1470129199004 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (122) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MONOMAC6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-123 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.896980813669841 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (123) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MV411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-124 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.73813403710182 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (124) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-125 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.231742209549576 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (125) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-126 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -2.10184023863776 | Decreased shRNA abundance (Z-score < -2) | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (126) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1299_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-127 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.09483711808961 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (127) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1437_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-128 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.04530579494798 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (128) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1650_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-129 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.43235820636413 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (129) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1792_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-13 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 2.58060492910177 | Increased shRNA abundance (Z-score > 2) | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (13) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | AML193_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-130 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.371774039670533 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (130) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH196_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-131 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.19455601425046 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (131) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1975_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-132 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.00375430292388068 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (132) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH2052_PLEURA | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-133 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.881749486230294 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (133) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH2122_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-134 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.374938268401736 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (134) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH2171_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-135 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.977506735984215 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (135) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH23_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-136 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.362138357009811 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (136) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH2452_PLEURA | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-137 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.948962328046954 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (137) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH441_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-138 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.137145578943697 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (138) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH508_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-139 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.588071505838647 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (139) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH660_PROSTATE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-14 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.696503350531357 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (14) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | ASPC1_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-140 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.623213728343651 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (140) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH661_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-141 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.277317201580391 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (141) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH716_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-142 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.45089040566031 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (142) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH838_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-143 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.0761202833516484 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (143) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIN87_STOMACH | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-144 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.764553409135664 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (144) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NIHOVCAR3_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-145 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.776551058166161 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (145) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NOMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-146 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.16749367252982 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (146) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OAW42_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-147 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.0637318169732 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (147) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-148 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.4377456640349 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (148) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-149 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.357238649345147 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (149) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-15 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.46865175537749 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (15) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | BT20_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-150 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.833471155355138 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (150) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OE33_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-151 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.0262321253782839 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (151) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OELE_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-152 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.824952618838329 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (152) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-153 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.106186534345559 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (153) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OV7_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-154 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.00511086233424 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (154) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OV90_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-155 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.854916221126664 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (155) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OVCAR4_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-156 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.580426064444736 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (156) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OVCAR8_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-157 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.11107820320981 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (157) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OVISE_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-158 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.722227192759031 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (158) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PANC0327_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-159 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.22854942312252 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (159) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PANC0813_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-16 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.507815185223443 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (16) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | BT474_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-160 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.24098984865865 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (160) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PANC1005_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-161 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.712910193271073 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (161) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PLB985_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-162 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.661423359455178 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (162) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PSN1_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-163 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.85952615079986 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (163) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | QGP1_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-164 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.98287122079191 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (164) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-165 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.229053166507037 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (165) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RKN_SOFT_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-166 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.71030110626078 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (166) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RKO_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-167 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.518173845780197 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (167) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RMGI_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-168 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.124054887827919 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (168) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RMUGS_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-169 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.934037077184561 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (169) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-17 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.448206003447505 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (17) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | BXPC3_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-170 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.162139549252993 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (170) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RT112_URINARY_TRACT | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-171 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.544175247030059 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (171) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-172 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.35460495193407 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (172) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SF126_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-173 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.37051961296138 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (173) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SF172_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-174 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.32252618341897 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (174) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SF295_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-175 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.0203782945939473 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (175) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SF767_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-176 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.0639456315427274 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (176) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SJSA1_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-177 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.07281522485754 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (177) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKCO1_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-178 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.167847523838625 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (178) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKMEL5_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-179 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.57293859526609 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (179) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKMM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-18 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.899660040060604 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (18) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | C2BBE1_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-180 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 2.09659552466048 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (180) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKNO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-181 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.776054902765838 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (181) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKOV3_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-182 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.62005708717281 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (182) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKRC20_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-183 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.29694981723798 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (183) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR20_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-184 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.53194107018746 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (184) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR21_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-185 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.955714609247333 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (185) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR23_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-186 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.26034342390258 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (186) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR24_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-187 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.926519176997103 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (187) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR25_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-188 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.33284252755093 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (188) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR26_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-189 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.785278382636125 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (189) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SNU1105_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-19 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.57227107157829 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (19) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | C32_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-190 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.69310877389072 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (190) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SNU840_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-191 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.848208714984779 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (191) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SNUC1_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-192 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.22570670300039 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (192) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SNUC2A_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-193 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -2.75842666571557 | Decreased shRNA abundance (Z-score < -2) | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (193) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SU8686_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-194 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.00613787963216055 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (194) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SW1417_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-195 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.973564220630548 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (195) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SW1783_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-196 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.539520053105705 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (196) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SW480_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-197 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.0101545431672 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (197) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SW48_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-198 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.185327253569168 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (198) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | T98G_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-199 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 2.17358378729851 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (199) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TC71_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-2 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 2.63486604997435 | Increased shRNA abundance (Z-score > 2) | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (2) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | 697_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-20 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.38718923211546 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (20) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CADOES1_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-200 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.941427444840891 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (200) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TCCSUP_URINARY_TRACT | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-201 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.665990265330646 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (201) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TE10_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-202 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.357206764048405 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (202) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TE15_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-203 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.85321428571992 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (203) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TE9_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-204 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.41331410632796 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (204) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-205 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.81133465022394 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (205) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TOV112D_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-206 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.835279029252398 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (206) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TOV21G_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-207 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.345826259113615 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (207) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TT_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-208 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.22207875500987 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (208) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TYKNU_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-209 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.06134198063567 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (209) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | U178_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-21 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.174711455798838 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (21) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAL120_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-210 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.627738120080817 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (210) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | U251MG_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-211 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.301240998455109 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (211) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | U343_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-212 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.175082560815531 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (212) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | U87MG_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-213 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.00377555780706682 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (213) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | UOK101_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-214 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.899997429591076 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (214) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | VCAP_PROSTATE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-215 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.303400441551094 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (215) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | YKG1_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-216 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.37152549874803 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (216) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | ZR7530_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-22 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.546769950997349 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (22) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAL51_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-23 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.191807189044528 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (23) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CALU1_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-24 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.0601521305442374 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (24) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAOV3_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-25 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.56371229624816 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (25) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAOV4_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-26 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.318401698423445 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (26) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAS1_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-27 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.0363161715615483 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (27) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CFPAC1_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-28 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.3455881750902 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (28) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CH157MN_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-29 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.40893363859897 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (29) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COLO205_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-3 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.827227839428469 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (3) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | 786O_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-30 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.14531989476447 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (30) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COLO704_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-31 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.390462854449693 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (31) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COLO741_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-32 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.706121241371407 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (32) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COLO783_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-33 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.01263750257657 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (33) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CORL23_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-34 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -2.53792991669766 | Decreased shRNA abundance (Z-score < -2) | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (34) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COV362_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-35 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.92875323715531 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (35) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COV434_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-36 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.203839259056213 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (36) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COV504_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-37 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.15167645132293 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (37) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COV644_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-38 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.00691579367219166 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (38) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | DBTRG05MG_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-39 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.573039066666652 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (39) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | DKMG_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-4 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.21654900613718 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (4) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A1207_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-40 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.808099813474869 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (40) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | DLD1_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-41 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.9539279997882 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (41) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EFE184_ENDOMETRIUM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-42 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.439773133352991 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (42) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EFM19_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-43 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.424674806209891 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (43) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EFO21_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-44 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.189655416577699 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (44) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EFO27_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-45 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.67453420437149 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (45) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EW8_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-46 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.20479468974933 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (46) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EWS502_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-47 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.81158211531465 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (47) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | F36P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-48 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.173121579936827 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (48) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | GB1_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-49 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -2.01126716414371 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (49) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | GP2D_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-5 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.717544722173159 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (5) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A172_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-50 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.0905388085507824 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (50) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC1187_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-51 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 2.11151056764984 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (51) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC1395_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-52 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.244379009915597 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (52) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC1954_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-53 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.363406594872571 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (53) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC2218_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-54 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.492214712827888 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (54) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC2814_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-55 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.048773347204419 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (55) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC364_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-56 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.70336386145254 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (56) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC44_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-57 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.421641933258226 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (57) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC70_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-58 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.58748054973422 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (58) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC827GR5_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-59 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.808359479232217 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (59) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC827_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-6 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.33825927804911 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (6) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A204_SOFT_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-60 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.83808624048303 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (60) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCT116_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-61 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.184988616328651 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (61) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HEC1A_ENDOMETRIUM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-62 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.806111701177023 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (62) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HEYA8_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-63 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 2.12296564022386 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (63) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-64 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.38229387888434 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (64) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HLF_LIVER | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-65 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.42203112880262 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (65) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HNT34_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-66 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.576632831844803 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (66) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HPAC_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-67 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.995090608881199 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (67) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HPAFII_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-68 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.444227202944087 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (68) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HS683_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-69 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.844392169992589 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (69) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HS766T_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-7 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.58185534073668 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (7) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A2058_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-70 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.120861224351953 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (70) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HS944T_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-71 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.13818831398653 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (71) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HT1197_URINARY_TRACT | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-72 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.538854799768821 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (72) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HT29_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-73 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.738874605467737 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (73) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HT55_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-74 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.353286865313148 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (74) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HUG1N_STOMACH | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-75 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.52813264013569 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (75) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HUTU80_SMALL_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-76 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.811908754662337 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (76) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | IGR39_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-77 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.706491209846254 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (77) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | IGROV1_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-78 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.35514512146317 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (78) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | IOMMLEE_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-79 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.318054212169923 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (79) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | JHESOAD1_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-8 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.55121542930511 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (8) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A549_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-80 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.669452423769219 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (80) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | JHOC5_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-81 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.92151271201105 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (81) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | JHOM1_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-82 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.33222821958173 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (82) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-83 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.52206326628442 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (83) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-84 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 2.01154668873027 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (84) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KALS1_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-85 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 2.75818954830084 | Increased shRNA abundance (Z-score > 2) | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (85) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-86 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.562423382864532 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (86) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KM12_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-87 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.126418067069338 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (87) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-88 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.247731542788924 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (88) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KNS60_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-89 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.376746833458941 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (89) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KNS81_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-9 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.586342503494 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (9) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A673_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-90 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -1.20706935608271 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (90) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KP1NL_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-91 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.668139823109788 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (91) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KP2_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-92 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 1.1909417186266 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (92) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KP4_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-93 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.646914611970412 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (93) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KURAMOCHI_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-94 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.873021398229725 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (94) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KYSE150_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-95 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.402631123151241 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (95) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KYSE30_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-96 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.75445574312963 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (96) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KYSE450_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-97 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.424725449066362 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (97) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KYSE510_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-98 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | -0.378165208594239 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (98) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | L33_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-99 | 375133 | | PI4KAP2 | TRCN0000052623, TRCN0000052624, TRCN0000052626, TRCN0000078688, TRCN0000078689, TRCN0000078691 | 0.0585944246455661 | none | | | PI4KAP2_1_10111110 | Context-specific genetic dependencies (99) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | | 375133 | 220686 | | | 0.22 | none | | | | | | | | | | | | | | | | | | | | 375133 | 375133 | PI4KAP2 | | -0.1 | none | | | | | | | | | | | | | | | | | | | GR00376-A-1 | 375133 | 375133 | LOC375133 | | 0.22626895 | none | | | | Mitigators of SS1P-induced immunotoxicity | Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity | Pasetto et al. | 2015 | 25713356 | Cell line | KB cells | Viability | Luminescence | Ambion Silencer Select Version 4 | Genome-wide | siRNA | RSA P-value | <0.001 | SS1P was applied in a "high dose", ≈EC90, 13 ng/ml. Cutoff was derived from data submitted to Pubchem (ID 1117281). Reagent sequences but no ID | GR00376-A-2 | 375133 | 375133 | LOC375133 | | 0.04692066 | none | | | | Sensitizers of SS1P-induced immunotoxicity | Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity | Pasetto et al. | 2015 | 25713356 | Cell line | KB cells | Viability | Luminescence | Ambion Silencer Select Version 4 | Genome-wide | siRNA | RSA P-value | <0.001 | SS1P was applied in a "low dose", ≈EC30, 3 ng/ml. Cutoff was derived from data submitted to PubChem (ID 1117281). Reagent sequences but no ID | GR00386-A-1 | 375133 | 375133 | PI4KAP2 | | 82.296561666561 | none | | | | NOD2 stimulation by MDP | A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. | Warner et al. | 2014 | 25170077 | Cell line | HEK293 stably expressing NOD2 | Viability | Luminescence | Dharmacon | Genome-wide | siRNA | Percentage growth | Decreased: <70, increased: >120 | Reagent IDs not provided | GR00386-A-2 | 375133 | 375133 | PI4KAP2 | | -61.6 | none | | | | MDP-induced IL-8 secretion | A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. | Warner et al. | 2014 | 25170077 | Cell line | HEK293 stably expressing NOD2 | IL-8 secretion | ELISA | Dharmacon | Genome-wide | siRNA | Percent inhibition of IL-8 secretion | Increased: <-300, Decreased: >60 | Concentration of IL-8 was measured from cell supernatants by sandwich ELISA. IL-8 values (pg/ml) were normalized to IL-8 secreted in cells treated with RIPK2-specific siRNA (100% inhibition) and non-targeting siRNA (0% inhibition). Secondary validating screen assessed 554 genes whose silencing affected MDP-induced IL-8 secretion in the primary screen. Final validated IL-8 regulators (positive or negative) are listed in the comments column. Reagent IDs not provided |