| GR00053-A | 3852 | NM_000424 | KRT5 | np | sp | none | | no | | Genome stability | A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. | Paulsen et al. | 2009 | 19647519 | Cell line | HeLa | gamma-H2AX phosphorylation and DNA content | Fluorescence | siARRAY human genome siRNA library | Genome-wide | siRNA | p-value | Complex criteria | Confidence groupings from 4 to 1 (highest level of confidence in group 4) | GR00054-A | 3852 | NM_000424 | KRT5 | np | 1.026 | none | | no | | Combinatorial effect with paclitaxel | Synthetic lethal screen identification of chemosensitizer loci in cancer cells. | Whitehurst et al. | 2007 | 17429401 | Cell line | NCI-H1155 | Viability (synthetic lethal) | ATP level | # G-005000-01 | Genome-wide | siRNA | Paclitaxel/control ratio | Complex criteria | Additional information about 87 high-confidence hits | GR00056-A | 3852 | NM_000424 | KRT5 | np | 0.939 | none | | no | | Melanogenesis | Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. | Ganesan et al. | 2008 | 19057677 | Cell line | MNT-1 | Melanin protein expression and viability | Absorbance and luminescence | rp | Genome-wide | siRNA | Normalized absorbance ratio | > 2 standard deviations below mean | Additional information about a secondary screen (retest to determine false-positive rate) | GR00057-A-1 | 3852 | NM_000424 | KRT5 | M-011067-00 | -0.54 | none | | no | | Wnt/beta-catenin pathway regulation (1) | A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. | Tang et al. | 2008 | 18621708 | Cell line | HeLa | Wnt pathway reporter | Luminescence | Human siArray siRNA library | Genome-wide | siRNA | Z-score | > 4 | Screen without Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries). | GR00057-A-2 | 3852 | NM_000424 | KRT5 | M-011067-00 | sp | none | | no | | Wnt/beta-catenin pathway regulation (2) | A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. | Tang et al. | 2008 | 18621708 | Cell line | HeLa | Wnt pathway reporter | Luminescence | Human siArray siRNA library | Genome-wide | siRNA | Complex, SP | Complex criteria | Screen with Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries). | GR00095-A | 3852 | NM_000424 | KRT5 | np | np | none | | | | p53 pathway components | A large-scale RNAi screen in human cells identifies new components of the p53 pathway | Berns et al. | 2004 | 15042092 | Cell line | BJ-TERT-tsLT fibroblasts | Proliferation | Colony-forming cell assay | Nki library | Genome-wide | shRNA | np | np | | GR00096-A | 3852 | NM_000424 | | NM_000424 siRNA1, NM_000424 siRNA2 | sp | Decreased nuclei size in G2M | | no | | Cell-cycle regulation | Genome-wide functional analysis of human cell-cycle regulators. | Mukherji et al. | 2006 | 17001007 | Cell line | U2OS | Cell number and nuclei size | Fluorescence | Custom-made | Genome-wide and druggable genes | siRNA | Complex, sp | np | Additional information about a secondary screen | GR00098-A-1 | 3852 | ENSG00000186081 | KRT5 | ENSG00000186081 | sp | none | | no | | Cell division (1) | Genome-scale RNAi profiling of cell division in human tissue culture cells. | Kittler et al. | 2007 | 17994010 | Cell line | HeLa | Cell number and DNA content | Laser scanning cytometry | rp | Genome-wide | esiRNA | Complex, sp | Complex criteria | | GR00123-A | 3852 | NM_000424 | KRT5 | 144491, 144492, 144493 | np | none | | | | Combinatorial effect with nutlin-3 | An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors | Brummelkamp et al. | 2006 | 16474381 | Cell line | MCF-7 | Viability | Fluoresence | Nki library | Genome-wide | shRNA | log2 ratio | np | | GR00149-A-1 | 3852 | 3852 | KRT5 | 8377 | 16.65 | none | | no | | Ciliogenesis and cilium length (1) | Functional genomic screen for modulators of ciliogenesis and cilium length. | Kim et al. | 2010 | 20393563 | Cell line | htRPE | Smoothed protein expression | Fluorescence | Human druggable genome siRNA library V3.1 | Druggable genes | siRNA | Normalized percent inhibition | > 1.5 OR < -1.5 standard deviations from mean | | GR00149-A-1 | 3852 | 3852 | KRT5 | 8377 | 56.43 | none | | no | | Ciliogenesis and cilium length (1) | Functional genomic screen for modulators of ciliogenesis and cilium length. | Kim et al. | 2010 | 20393563 | Cell line | htRPE | Smoothed protein expression | Fluorescence | Human druggable genome siRNA library V3.1 | Druggable genes | siRNA | Normalized percent inhibition | > 1.5 OR < -1.5 standard deviations from mean | | GR00149-A-1 | 3852 | 3852 | KRT5 | 8473 | -10.91 | none | | no | | Ciliogenesis and cilium length (1) | Functional genomic screen for modulators of ciliogenesis and cilium length. | Kim et al. | 2010 | 20393563 | Cell line | htRPE | Smoothed protein expression | Fluorescence | Human druggable genome siRNA library V3.1 | Druggable genes | siRNA | Normalized percent inhibition | > 1.5 OR < -1.5 standard deviations from mean | | GR00149-A-1 | 3852 | 3852 | KRT5 | 8473 | -46.22 | none | | no | | Ciliogenesis and cilium length (1) | Functional genomic screen for modulators of ciliogenesis and cilium length. | Kim et al. | 2010 | 20393563 | Cell line | htRPE | Smoothed protein expression | Fluorescence | Human druggable genome siRNA library V3.1 | Druggable genes | siRNA | Normalized percent inhibition | > 1.5 OR < -1.5 standard deviations from mean | | GR00149-A-1 | 3852 | 3852 | KRT5 | 8565 | -36.11 | none | | no | | Ciliogenesis and cilium length (1) | Functional genomic screen for modulators of ciliogenesis and cilium length. | Kim et al. | 2010 | 20393563 | Cell line | htRPE | Smoothed protein expression | Fluorescence | Human druggable genome siRNA library V3.1 | Druggable genes | siRNA | Normalized percent inhibition | > 1.5 OR < -1.5 standard deviations from mean | | GR00149-A-1 | 3852 | 3852 | KRT5 | 8565 | -48.71 | none | | no | | Ciliogenesis and cilium length (1) | Functional genomic screen for modulators of ciliogenesis and cilium length. | Kim et al. | 2010 | 20393563 | Cell line | htRPE | Smoothed protein expression | Fluorescence | Human druggable genome siRNA library V3.1 | Druggable genes | siRNA | Normalized percent inhibition | > 1.5 OR < -1.5 standard deviations from mean | | GR00149-A-1 | 3852 | 3852 | KRT5 | 289145 | -141.78 | none | | no | | Ciliogenesis and cilium length (1) | Functional genomic screen for modulators of ciliogenesis and cilium length. | Kim et al. | 2010 | 20393563 | Cell line | htRPE | Smoothed protein expression | Fluorescence | Human druggable genome siRNA library V3.1 | Druggable genes | siRNA | Normalized percent inhibition | > 1.5 OR < -1.5 standard deviations from mean | | GR00149-A-1 | 3852 | 3852 | KRT5 | 289145 | -26.02 | none | | no | | Ciliogenesis and cilium length (1) | Functional genomic screen for modulators of ciliogenesis and cilium length. | Kim et al. | 2010 | 20393563 | Cell line | htRPE | Smoothed protein expression | Fluorescence | Human druggable genome siRNA library V3.1 | Druggable genes | siRNA | Normalized percent inhibition | > 1.5 OR < -1.5 standard deviations from mean | | GR00151-A-1 | 3852 | ENSG00000186081 | KRT5 | np | -0.206 | none | | no | | Homologous recombination DNA double-strand break repair (HR-DSBR) (1) | A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. | Słabicki et al. | 2010 | 20613862 | Cell line | HeLa | (HR-DSBR) DR-GFP reporter | Flow cytometry | Custom-made | Genome-wide | esiRNA | Z-score | < -2 OR > 2 | | GR00180-A-1 | 3852 | 3852 | KRT5 | PL-50019 | 0.646 | none | | no | | Hepatitis C virus replication (1) | A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. | Tai et al. | 2009 | 19286138 | Cell line | Huh7/Rep-Feo | HCV replicon RNA copy number | Luminescence | siARRAY Human Genome siRNA Library | Genome-wide | siRNA | q-value | Complex criteria | | GR00184-A-1 | 3852 | NM_000424 | KRT5 | M-011067-00 | -0.338497836861837 | none | | no | | Self-renewal and pluripotency in human embryonic stem cells (1) | A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. | Chia et al. | 2010 | 20953172 | Cell line | hESC H1 | POU5F1 protein expression | Fluorescence | SMARTpool siRNA library | Genome-wide | siRNA | Z-score | < -2 | | GR00196-A-1 | 3852 | ENSG00000186081 | | np | sp | none | | no | | TP53 interactions (1) | A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly. | Krastev et al. | 2011 | 21642980 | Cell line | HCT116 ( wildtype and TP53 knockout) | TP53 protein expression and viability | Fluorescence | rp | Genome-wide | esiRNA | Complex, sp | Complex criteria | | GR00197-A-1 | 3852 | 3852 | KRT5 | M-011067-00 | -0.448725376 | none | | no | | Human papillomavirus oncogene expression regulation (1) | Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. | Smith et al. | 2010 | 20133580 | Cell line | C33A/BE2/18LCR c4 | HPV18 LCR reporter activity | Luminescence | Human siGENOME SMARTpool library | Genome-wide | siRNA | Z-score | > | Author-submitted data. Phenotype strength according to Z-scores: weak: 2 - 3; moderate: 3 - 5; strong: > 5 | GR00236-A-1 | 3852 | 3852 | KRT5 | M-011067-00 | 1.10092846880233 | none | | no | | Homologous recombination DNA double-strand break repair (HR-DSBR) (1) | A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. | Adamson et al. | 2012 | 22344029 | Cell line | DR-U2OS | (HR-DSBR) DR-GFP reporter and DNA content | Fluorescence | Human siGENOME siRNA (G-005000-05) | Genome-wide | siRNA | Relative HR ratio | < ~0.4 OR > 1.88 | Cutoff values correspond 2 standard deviations from the screen-wide mean | GR00240-S-1 | 3852 | NM_000424 | KRT5 | M-011067-00 | 1.91 | none | | yes | | TRAIL-induced apoptosis (1) | A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. | Kranz and Boutros | 2014 | 24442637 | Cell line | U251MG | Viability | Luminescence | SMART-pool siRNA | Genome-wide | siRNA | Z-score | > 4 | Author-submitted data | GR00240-S-2 | 3852 | NM_000424 | KRT5 | M-011067-00 | -0.48 | none | | no | Z-score 1.717 | TRAIL-induced apoptosis (2) | A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. | Kranz and Boutros | 2014 | 24442637 | Cell line | U251MG | Viability (synthetic lethal) | Luminescence | SMART-pool siRNA | Genome-wide | siRNA | Differential score | > 3.6 AND viability Z-score < 4 | Author-submitted data. Z-scores from viability screen (1) are considered in score interpretation for this screen. | GR00242-A-1 | 3852 | NM_000424 | KRT5 | np | sp | none | | no | | Selective autophagy regulation (1) | Image-based genome-wide siRNA screen identifies selective autophagy factors. | Orvedahl et al. | 2011 | 22020285 | Cell line | HeLa/GFP-LC3 | Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression | Fluorescence | siGenome | Genome-wide | siRNA | Z-score | Complex criteria | | GR00247-A-1 | 3852 | | KRT5 | np | sp | none | | | rank: 9193 | Regulation of FOXO1 nuclear localization (1) | Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain. | Senapedis et al. | 2011 | 21460183 | Cell line | U2OS | EGFP-FOXO1a protein expression and DNA content | Fluorescence | Human Genome library | Genome-wide | siRNA | Complex, sp | Complex criteria | | GR00249-S | 3852 | 3852 | KRT5 | J-011067-05 | -0.64132 | none | | no | number of cells compared to control (%): 86.37 | Vaccinia virus (VACV) infection | Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan et al. | 2013 | 23401514 | Cell line | HeLa | Vaccinia virus VACV IHD-J/GFP protein expression and DNA content | Fluorescence | Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus | Genome-wide | siRNA | Z-score | > | Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. | GR00249-S | 3852 | 3852 | KRT5 | M-011067-01 | 0.57451 | none | | no | number of cells compared to control (%): 81.63 | Vaccinia virus (VACV) infection | Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan et al. | 2013 | 23401514 | Cell line | HeLa | Vaccinia virus VACV IHD-J/GFP protein expression and DNA content | Fluorescence | Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus | Genome-wide | siRNA | Z-score | > | Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. | GR00249-S | 3852 | 3852 | KRT5 | s7956 | -0.01177 | none | | no | number of cells compared to control (%): 92.28 | Vaccinia virus (VACV) infection | Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan et al. | 2013 | 23401514 | Cell line | HeLa | Vaccinia virus VACV IHD-J/GFP protein expression and DNA content | Fluorescence | Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus | Genome-wide | siRNA | Z-score | > | Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. | GR00249-S | 3852 | 3852 | KRT5 | s7957 | 1.13669 | Increased vaccinia virus (VACV) infection | | no | number of cells compared to control (%): 73.17 | Vaccinia virus (VACV) infection | Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan et al. | 2013 | 23401514 | Cell line | HeLa | Vaccinia virus VACV IHD-J/GFP protein expression and DNA content | Fluorescence | Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus | Genome-wide | siRNA | Z-score | > | Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. | GR00249-S | 3852 | 3852 | KRT5 | s7958 | -0.99763 | none | | no | number of cells compared to control (%): 60.94 | Vaccinia virus (VACV) infection | Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan et al. | 2013 | 23401514 | Cell line | HeLa | Vaccinia virus VACV IHD-J/GFP protein expression and DNA content | Fluorescence | Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus | Genome-wide | siRNA | Z-score | > | Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. | GR00253-A | 3852 | NM_000424 | KRT5 | np | 1.146 | none | | | | hepcidin regulation | Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. | Mleczko-Sanecka et al. | 2014 | 24385536 | Cell line | Huh7 | hepcidin::fluc mRNA expression | Luminescence | siGenome siARRAY SMARTpool | Genome-wide | siRNA | Z-score | > | Cutoff < | GR00255-A-1 | 3852 | 3856 | KRT8 | TRCN0000062383, TRCN0000062384, TRCN0000062385, TRCN0000062386, TRCN0000062387 | -0.100667623 | none | | | | Negative genetic interactions (1) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.0 | HCT116 BLM-/- and HCT116 BLM+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-1 | 3852 | 3852 | KRT5 | TRCN0000083878, TRCN0000083879, TRCN0000083882 | -0.454041372 | none | | | | Negative genetic interactions (1) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.0 | HCT116 BLM-/- and HCT116 BLM+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-1 | 3852 | 140446 | KRT6C | TRCN0000117307, TRCN0000117308, TRCN0000117309, TRCN0000117310, TRCN0000117311 | -0.107648755 | none | | | | Negative genetic interactions (1) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.0 | HCT116 BLM-/- and HCT116 BLM+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-2 | 3852 | 3856 | KRT8 | TRCN0000062383, TRCN0000062384, TRCN0000062385, TRCN0000062386, TRCN0000062387 | 0.238310638 | none | | | | Negative genetic interactions (2) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.0 | HCT116 MUS81-/- and HCT116 MUS81+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-2 | 3852 | 140446 | KRT6C | TRCN0000117307, TRCN0000117308, TRCN0000117309, TRCN0000117310, TRCN0000117311 | -0.355076472 | none | | | | Negative genetic interactions (2) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.0 | HCT116 MUS81-/- and HCT116 MUS81+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-2 | 3852 | 3852 | KRT5 | TRCN0000083878, TRCN0000083879, TRCN0000083882 | -0.277840115 | none | | | | Negative genetic interactions (2) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.0 | HCT116 MUS81-/- and HCT116 MUS81+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-3 | 3852 | 3856 | KRT8 | TRCN0000062383, TRCN0000062384, TRCN0000062385, TRCN0000062386, TRCN0000062387 | -0.361544607 | none | | | | Negative genetic interactions (3) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.2 | HCT116 PTEN-/- and HCT116 PTEN+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-3 | 3852 | 140446 | KRT6C | TRCN0000117307, TRCN0000117308, TRCN0000117309, TRCN0000117310, TRCN0000117311 | -0.236845879 | none | | | | Negative genetic interactions (3) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.2 | HCT116 PTEN-/- and HCT116 PTEN+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-3 | 3852 | 3852 | KRT5 | TRCN0000083878, TRCN0000083879, TRCN0000083882 | -0.385393065 | none | | | | Negative genetic interactions (3) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.2 | HCT116 PTEN-/- and HCT116 PTEN+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-4 | 3852 | 3856 | KRT8 | TRCN0000062383, TRCN0000062384, TRCN0000062385, TRCN0000062386, TRCN0000062387 | -0.223643553 | none | | | | Negative genetic interactions (4) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.2 | HCT116 PTTG1-/- and HCT116 PTTG1+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-4 | 3852 | 140446 | KRT6C | TRCN0000117307, TRCN0000117308, TRCN0000117309, TRCN0000117310, TRCN0000117311 | -0.542666972 | none | | | | Negative genetic interactions (4) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.2 | HCT116 PTTG1-/- and HCT116 PTTG1+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-4 | 3852 | 3852 | KRT5 | TRCN0000083878, TRCN0000083879, TRCN0000083882 | -0.377334358 | none | | | | Negative genetic interactions (4) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.2 | HCT116 PTTG1-/- and HCT116 PTTG1+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-5 | 3852 | 3856 | KRT8 | TRCN0000062383, TRCN0000062384, TRCN0000062385, TRCN0000062386, TRCN0000062387 | 0.290172605 | none | | | | Negative genetic interactions (5) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -0.8 | HCT116 KRASG13D/- and HCT116 KRAS+/- cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-5 | 3852 | 140446 | KRT6C | TRCN0000117307, TRCN0000117308, TRCN0000117309, TRCN0000117310, TRCN0000117311 | 0.330550326 | none | | | | Negative genetic interactions (5) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -0.8 | HCT116 KRASG13D/- and HCT116 KRAS+/- cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-5 | 3852 | 3852 | KRT5 | TRCN0000083878, TRCN0000083879, TRCN0000083882 | 0.39588401 | none | | | | Negative genetic interactions (5) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -0.8 | HCT116 KRASG13D/- and HCT116 KRAS+/- cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00257-A-1 | 3852 | | krt5 | 8377 | sp | Two nuclei (binuclear) | | | | Cell division, migration and survival (1) | Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. | Neumann et al. | 2010 | 20360735 | Cell line | HeLa | H2B-GFP protein expression | Fluorescence | Mapped using ENSEMBL genome database version 27 | Selected genes | siRNA | Complex, sp | Complex criteria | HeLa-H2B-GFP cells used. | GR00293-A | 3852 | | KRT5 | np | 0.819 | none | | | | Combinatorial effect with paclitaxel | Mechanisms Promoting Escape from Mitotic Stress−Induced Tumor Cell Death | Sinnott et al. | 2014 | 24860162 | Cell line | HCC366 | Viability | Luminescence | Thermo-Fisher | Genome-wide | siRNA | Z-score | < -2.5 | Final hits according to the author are indicated in the comment. | GR00300-A | 3852 | | KRT5 | TRCN0000083878, TRCN0000083882, TRCN0000083879 | 0 | none | | | | Combinatorial effect with RAF inhibitor PLX4720 | A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition. | Whittaker et al. | 2013 | 23288408 | Cell line | A375 | shRNA abundance | Sequencing | TRC | Genome-wide | shRNA | Number of shRNAs ranked Top1000 | > 2 | The A375 cell line used here harbours the BRAF V600E mutation and is therefore sensitive to RAF inhibitors. | GR00300-A | 3852 | | KRT8 | TRCN0000062387, TRCN0000062386, TRCN0000062385, TRCN0000062384, TRCN0000062383 | 0 | none | | | | Combinatorial effect with RAF inhibitor PLX4720 | A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition. | Whittaker et al. | 2013 | 23288408 | Cell line | A375 | shRNA abundance | Sequencing | TRC | Genome-wide | shRNA | Number of shRNAs ranked Top1000 | > 2 | The A375 cell line used here harbours the BRAF V600E mutation and is therefore sensitive to RAF inhibitors. | GR00300-A | 3852 | | KRT6C | TRCN0000117309, TRCN0000117160, TRCN0000117307, TRCN0000117161, TRCN0000117308, TRCN0000117157, TRCN0000117159, TRCN0000117158, TRCN0000117310, TRCN0000117311 | 1 | none | | | | Combinatorial effect with RAF inhibitor PLX4720 | A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition. | Whittaker et al. | 2013 | 23288408 | Cell line | A375 | shRNA abundance | Sequencing | TRC | Genome-wide | shRNA | Number of shRNAs ranked Top1000 | > 2 | The A375 cell line used here harbours the BRAF V600E mutation and is therefore sensitive to RAF inhibitors. | GR00303-A | 3852 | NM_000424 | KRT5 | np | 0.45 | none | | | | Clear cell renal cell carcinoma (ccRCC) survival regulation | Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target | Gerlinger et al. | 2012 | 22362593 | Cell line | VHL-deficient RCC4 | Proliferation and Viability | Fluorescence | np | Genome-wide | siRNA | Z-score | < | In the phenotype data duplicates were in the original document, which have been removed. | GR00310-A-1 | 3852 | 3852 | KRT5 | np | 0.27 | none | | | | Sindbis virus (SINV) infection (1) | Genome-Wide RNAi Screen Identifies Novel Host Proteins Required for Alphavirus Entry | Ooi et al. | 2013 | 24367265 | Cell line | U2OS | Sindbis virus (SINV) reporter | Luminescence | Ambion Silencer V3 | Genome-wide | siRNA | Z-score | < -3 OR > 2 | | | 3852 | 3852 | KRT5 | np | 15.3 | none | | | 111,5% viability | | | | | | | | | | | | | | | | GR00313-A | 3852 | NM_000424 | KRT5 | np | -0.33 | none | | | | TNF-alpha pathway regulation | A Genome-Wide RNA Interference Screen Identifies Caspase 4 as a Factor Required for Tumor Necrosis Factor Alpha Signaling. | Nickles et al. | 2012 | 22733992 | Cell line | HEK293T | NFkappaB pathway reporter | Luminescence | Qiagen | Genome-wide | siRNA | Z-score | < | Additional filters were a reduction in firefly luciferase levels by at least 50% compared to the mean of the experiment and a concomitant reduction of renilla luciferase expression of not more than 30%. | GR00318-A | 3852 | 3852 | KRT5 | np | 1.904 | none | | | siRNA set: druggable genome | Huntingtin toxicity | A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington’s Disease | Miller et al. | 2012 | 23209424 | Cell line | HEK293T | Caspase 3/7 activity | Fluorescence | Dharmacon | Selected genes | siRNA | Sum of normalized caspase 3/7 activity mean and standard error | < 0.683 | HEK293T cells were cotransfected with mutant Huntingtin fused to GFP (Htt1-558141Q-GFP). | GR00327-A | 3852 | 3852 | NDEL1 | CLL-H-017679 | 0.5631423488017991 | none | | | | Tumor formation | An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation | Wolf et al. | 2013 | 24292671 | Cell line | SUM-149 | shRNA abundance | Next-generation sequencing | Decipher library module 1 | Selected genes | shRNA | Z-score | > 2.24 | Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. | GR00327-A | 3852 | 3852 | NDEL1 | CLL-H-017680 | -1.2213318789148933 | none | | | | Tumor formation | An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation | Wolf et al. | 2013 | 24292671 | Cell line | SUM-149 | shRNA abundance | Next-generation sequencing | Decipher library module 1 | Selected genes | shRNA | Z-score | > 2.24 | Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. | GR00327-A | 3852 | 3852 | NDEL1 | CLL-H-017678 | -0.4237981517034415 | none | | | | Tumor formation | An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation | Wolf et al. | 2013 | 24292671 | Cell line | SUM-149 | shRNA abundance | Next-generation sequencing | Decipher library module 1 | Selected genes | shRNA | Z-score | > 2.24 | Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. | GR00327-A | 3852 | 3852 | NDEL1 | CLL-H-017677 | 0.9086467416086238 | none | | | | Tumor formation | An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation | Wolf et al. | 2013 | 24292671 | Cell line | SUM-149 | shRNA abundance | Next-generation sequencing | Decipher library module 1 | Selected genes | shRNA | Z-score | > 2.24 | Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. | GR00327-A | 3852 | 3852 | NDEL1 | CLL-H-017676 | -1.270597695033918 | none | | | | Tumor formation | An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation | Wolf et al. | 2013 | 24292671 | Cell line | SUM-149 | shRNA abundance | Next-generation sequencing | Decipher library module 1 | Selected genes | shRNA | Z-score | > 2.24 | Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. | GR00366-A-1 | 3852 | | KRT5 | TRCN0000083882 | -0.229683520481489 | none | | | KRT5_1_011 | Context-specific genetic dependencies (1) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | 22RV1_PROSTATE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-10 | 3852 | | KRT5 | TRCN0000083882 | -1.01226258696398 | none | | | KRT5_1_011 | Context-specific genetic dependencies (10) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | ACHN_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-100 | 3852 | | KRT5 | TRCN0000083882 | 0.702729544601687 | none | | | KRT5_1_011 | Context-specific genetic dependencies (100) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LAMA84_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-101 | 3852 | | KRT5 | TRCN0000083882 | -0.205156075396937 | none | | | KRT5_1_011 | Context-specific genetic dependencies (101) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LK2_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-102 | 3852 | | KRT5 | TRCN0000083882 | 1.08255741403466 | none | | | KRT5_1_011 | Context-specific genetic dependencies (102) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN215_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-103 | 3852 | | KRT5 | TRCN0000083882 | 0.122089559453466 | none | | | KRT5_1_011 | Context-specific genetic dependencies (103) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN229_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-104 | 3852 | | KRT5 | TRCN0000083882 | -0.430346920089553 | none | | | KRT5_1_011 | Context-specific genetic dependencies (104) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN235_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-105 | 3852 | | KRT5 | TRCN0000083882 | 1.18323116088522 | none | | | KRT5_1_011 | Context-specific genetic dependencies (105) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN319_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-106 | 3852 | | KRT5 | TRCN0000083882 | -0.0231884329821924 | none | | | KRT5_1_011 | Context-specific genetic dependencies (106) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN340_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-107 | 3852 | | KRT5 | TRCN0000083882 | 1.25048449150277 | none | | | KRT5_1_011 | Context-specific genetic dependencies (107) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN382_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-108 | 3852 | | KRT5 | TRCN0000083882 | -0.734528955266379 | none | | | KRT5_1_011 | Context-specific genetic dependencies (108) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN428_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-109 | 3852 | | KRT5 | TRCN0000083882 | -1.10027378744075 | none | | | KRT5_1_011 | Context-specific genetic dependencies (109) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN443_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-11 | 3852 | | KRT5 | TRCN0000083882 | 0.154134099633814 | none | | | KRT5_1_011 | Context-specific genetic dependencies (11) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | AGS_STOMACH | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-110 | 3852 | | KRT5 | TRCN0000083882 | 0.991575042179181 | none | | | KRT5_1_011 | Context-specific genetic dependencies (110) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN464_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-111 | 3852 | | KRT5 | TRCN0000083882 | 0.666934711877697 | none | | | KRT5_1_011 | Context-specific genetic dependencies (111) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LNZ308_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-112 | 3852 | | KRT5 | TRCN0000083882 | 1.08424256917802 | none | | | KRT5_1_011 | Context-specific genetic dependencies (112) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LOVO_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-113 | 3852 | | KRT5 | TRCN0000083882 | 0.34434174866199 | none | | | KRT5_1_011 | Context-specific genetic dependencies (113) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LS411N_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-114 | 3852 | | KRT5 | TRCN0000083882 | -0.919622534635788 | none | | | KRT5_1_011 | Context-specific genetic dependencies (114) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LS513_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-115 | 3852 | | KRT5 | TRCN0000083882 | -0.330144023558015 | none | | | KRT5_1_011 | Context-specific genetic dependencies (115) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MCF7_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-116 | 3852 | | KRT5 | TRCN0000083882 | -0.230198607540866 | none | | | KRT5_1_011 | Context-specific genetic dependencies (116) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MDAMB453_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-117 | 3852 | | KRT5 | TRCN0000083882 | -0.18012211333376 | none | | | KRT5_1_011 | Context-specific genetic dependencies (117) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MIAPACA2_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-118 | 3852 | | KRT5 | TRCN0000083882 | 0.63994513300504 | none | | | KRT5_1_011 | Context-specific genetic dependencies (118) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MKN7_STOMACH | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-119 | 3852 | | KRT5 | TRCN0000083882 | -0.806107025899224 | none | | | KRT5_1_011 | Context-specific genetic dependencies (119) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-12 | 3852 | | KRT5 | TRCN0000083882 | 1.0033015592919 | none | | | KRT5_1_011 | Context-specific genetic dependencies (12) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | AM38_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-120 | 3852 | | KRT5 | TRCN0000083882 | 0.25885431093639 | none | | | KRT5_1_011 | Context-specific genetic dependencies (120) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-121 | 3852 | | KRT5 | TRCN0000083882 | 0.208265124251295 | none | | | KRT5_1_011 | Context-specific genetic dependencies (121) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-122 | 3852 | | KRT5 | TRCN0000083882 | 0.153854563764546 | none | | | KRT5_1_011 | Context-specific genetic dependencies (122) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MONOMAC6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-123 | 3852 | | KRT5 | TRCN0000083882 | -0.886729556460891 | none | | | KRT5_1_011 | Context-specific genetic dependencies (123) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MV411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-124 | 3852 | | KRT5 | TRCN0000083882 | -0.187194068352795 | none | | | KRT5_1_011 | Context-specific genetic dependencies (124) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-125 | 3852 | | KRT5 | TRCN0000083882 | -0.601786722421605 | none | | | KRT5_1_011 | Context-specific genetic dependencies (125) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-126 | 3852 | | KRT5 | TRCN0000083882 | -0.398527848651369 | none | | | KRT5_1_011 | Context-specific genetic dependencies (126) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1299_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-127 | 3852 | | KRT5 | TRCN0000083882 | 0.103559028375841 | none | | | KRT5_1_011 | Context-specific genetic dependencies (127) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1437_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-128 | 3852 | | KRT5 | TRCN0000083882 | -1.17345156447062 | none | | | KRT5_1_011 | Context-specific genetic dependencies (128) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1650_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-129 | 3852 | | KRT5 | TRCN0000083882 | -0.470985486836793 | none | | | KRT5_1_011 | Context-specific genetic dependencies (129) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1792_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-13 | 3852 | | KRT5 | TRCN0000083882 | 1.75838944511649 | Increased shRNA abundance (Z-score > 2) | | | KRT5_1_011 | Context-specific genetic dependencies (13) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | AML193_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-130 | 3852 | | KRT5 | TRCN0000083882 | -0.00911623435512925 | none | | | KRT5_1_011 | Context-specific genetic dependencies (130) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH196_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-131 | 3852 | | KRT5 | TRCN0000083882 | -0.134344396838491 | none | | | KRT5_1_011 | Context-specific genetic dependencies (131) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1975_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-132 | 3852 | | KRT5 | TRCN0000083882 | 0.367081575725942 | none | | | KRT5_1_011 | Context-specific genetic dependencies (132) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH2052_PLEURA | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-133 | 3852 | | KRT5 | TRCN0000083882 | -0.841127904712857 | none | | | KRT5_1_011 | Context-specific genetic dependencies (133) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH2122_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-134 | 3852 | | KRT5 | TRCN0000083882 | 0.656689684459855 | none | | | KRT5_1_011 | Context-specific genetic dependencies (134) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH2171_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-135 | 3852 | | KRT5 | TRCN0000083882 | 1.23810589206922 | none | | | KRT5_1_011 | Context-specific genetic dependencies (135) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH23_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-136 | 3852 | | KRT5 | TRCN0000083882 | -0.455782541672728 | none | | | KRT5_1_011 | Context-specific genetic dependencies (136) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH2452_PLEURA | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-137 | 3852 | | KRT5 | TRCN0000083882 | 0.693346062360723 | none | | | KRT5_1_011 | Context-specific genetic dependencies (137) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH441_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-138 | 3852 | | KRT5 | TRCN0000083882 | -0.00744406036349515 | none | | | KRT5_1_011 | Context-specific genetic dependencies (138) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH508_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-139 | 3852 | | KRT5 | TRCN0000083882 | -1.09828830137923 | none | | | KRT5_1_011 | Context-specific genetic dependencies (139) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH660_PROSTATE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-14 | 3852 | | KRT5 | TRCN0000083882 | 0.0981921413348598 | none | | | KRT5_1_011 | Context-specific genetic dependencies (14) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | ASPC1_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-140 | 3852 | | KRT5 | TRCN0000083882 | 0.943183829146037 | none | | | KRT5_1_011 | Context-specific genetic dependencies (140) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH661_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-141 | 3852 | | KRT5 | TRCN0000083882 | -0.705559687739774 | none | | | KRT5_1_011 | Context-specific genetic dependencies (141) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH716_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-142 | 3852 | | KRT5 | TRCN0000083882 | -0.0314544018990826 | none | | | KRT5_1_011 | Context-specific genetic dependencies (142) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH838_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-143 | 3852 | | KRT5 | TRCN0000083882 | 1.81487031025809 | Increased shRNA abundance (Z-score > 2) | | | KRT5_1_011 | Context-specific genetic dependencies (143) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIN87_STOMACH | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-144 | 3852 | | KRT5 | TRCN0000083882 | 1.3372980231943 | none | | | KRT5_1_011 | Context-specific genetic dependencies (144) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NIHOVCAR3_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-145 | 3852 | | KRT5 | TRCN0000083882 | -0.158200350889924 | none | | | KRT5_1_011 | Context-specific genetic dependencies (145) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NOMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-146 | 3852 | | KRT5 | TRCN0000083882 | -0.765280421497815 | none | | | KRT5_1_011 | Context-specific genetic dependencies (146) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OAW42_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-147 | 3852 | | KRT5 | TRCN0000083882 | 0.247557936259111 | none | | | KRT5_1_011 | Context-specific genetic dependencies (147) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-148 | 3852 | | KRT5 | TRCN0000083882 | -1.12369859081195 | none | | | KRT5_1_011 | Context-specific genetic dependencies (148) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-149 | 3852 | | KRT5 | TRCN0000083882 | 0.611378155151431 | none | | | KRT5_1_011 | Context-specific genetic dependencies (149) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-15 | 3852 | | KRT5 | TRCN0000083882 | -0.614547824724055 | none | | | KRT5_1_011 | Context-specific genetic dependencies (15) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | BT20_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-150 | 3852 | | KRT5 | TRCN0000083882 | 0.530846618682464 | none | | | KRT5_1_011 | Context-specific genetic dependencies (150) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OE33_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-151 | 3852 | | KRT5 | TRCN0000083882 | -0.222394288709247 | none | | | KRT5_1_011 | Context-specific genetic dependencies (151) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OELE_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-152 | 3852 | | KRT5 | TRCN0000083882 | -0.479595645320396 | none | | | KRT5_1_011 | Context-specific genetic dependencies (152) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-153 | 3852 | | KRT5 | TRCN0000083882 | -1.69768075749046 | Decreased shRNA abundance (Z-score < -2) | | | KRT5_1_011 | Context-specific genetic dependencies (153) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OV7_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-154 | 3852 | | KRT5 | TRCN0000083882 | 0.811198410050115 | none | | | KRT5_1_011 | Context-specific genetic dependencies (154) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OV90_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-155 | 3852 | | KRT5 | TRCN0000083882 | -1.07456883846685 | none | | | KRT5_1_011 | Context-specific genetic dependencies (155) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OVCAR4_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-156 | 3852 | | KRT5 | TRCN0000083882 | 0.624715595384521 | none | | | KRT5_1_011 | Context-specific genetic dependencies (156) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OVCAR8_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-157 | 3852 | | KRT5 | TRCN0000083882 | 0.132473976714144 | none | | | KRT5_1_011 | Context-specific genetic dependencies (157) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OVISE_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-158 | 3852 | | KRT5 | TRCN0000083882 | 1.41616444338519 | none | | | KRT5_1_011 | Context-specific genetic dependencies (158) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PANC0327_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-159 | 3852 | | KRT5 | TRCN0000083882 | 0.636678167809748 | none | | | KRT5_1_011 | Context-specific genetic dependencies (159) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PANC0813_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-16 | 3852 | | KRT5 | TRCN0000083882 | -0.0609906810919793 | none | | | KRT5_1_011 | Context-specific genetic dependencies (16) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | BT474_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-160 | 3852 | | KRT5 | TRCN0000083882 | 0.633045797896859 | none | | | KRT5_1_011 | Context-specific genetic dependencies (160) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PANC1005_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-161 | 3852 | | KRT5 | TRCN0000083882 | 0.163922770251557 | none | | | KRT5_1_011 | Context-specific genetic dependencies (161) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PLB985_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-162 | 3852 | | KRT5 | TRCN0000083882 | -0.385445746412479 | none | | | KRT5_1_011 | Context-specific genetic dependencies (162) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PSN1_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-163 | 3852 | | KRT5 | TRCN0000083882 | 0.0679531155202151 | none | | | KRT5_1_011 | Context-specific genetic dependencies (163) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | QGP1_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-164 | 3852 | | KRT5 | TRCN0000083882 | 0.516266138648387 | none | | | KRT5_1_011 | Context-specific genetic dependencies (164) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-165 | 3852 | | KRT5 | TRCN0000083882 | 0.184758527021146 | none | | | KRT5_1_011 | Context-specific genetic dependencies (165) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RKN_SOFT_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-166 | 3852 | | KRT5 | TRCN0000083882 | -0.38152329607018 | none | | | KRT5_1_011 | Context-specific genetic dependencies (166) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RKO_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-167 | 3852 | | KRT5 | TRCN0000083882 | -1.07515639312083 | none | | | KRT5_1_011 | Context-specific genetic dependencies (167) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RMGI_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-168 | 3852 | | KRT5 | TRCN0000083882 | 0.839248410385359 | none | | | KRT5_1_011 | Context-specific genetic dependencies (168) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RMUGS_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-169 | 3852 | | KRT5 | TRCN0000083882 | -0.124158099679927 | none | | | KRT5_1_011 | Context-specific genetic dependencies (169) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-17 | 3852 | | KRT5 | TRCN0000083882 | 2.50239634255801 | Increased shRNA abundance (Z-score > 2) | | | KRT5_1_011 | Context-specific genetic dependencies (17) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | BXPC3_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-170 | 3852 | | KRT5 | TRCN0000083882 | 0.605398507336608 | none | | | KRT5_1_011 | Context-specific genetic dependencies (170) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RT112_URINARY_TRACT | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-171 | 3852 | | KRT5 | TRCN0000083882 | -0.215748569177074 | none | | | KRT5_1_011 | Context-specific genetic dependencies (171) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-172 | 3852 | | KRT5 | TRCN0000083882 | -0.315971252512703 | none | | | KRT5_1_011 | Context-specific genetic dependencies (172) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SF126_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-173 | 3852 | | KRT5 | TRCN0000083882 | -0.0126764727550137 | none | | | KRT5_1_011 | Context-specific genetic dependencies (173) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SF172_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-174 | 3852 | | KRT5 | TRCN0000083882 | -0.315396805041052 | none | | | KRT5_1_011 | Context-specific genetic dependencies (174) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SF295_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-175 | 3852 | | KRT5 | TRCN0000083882 | 0.484540455884291 | none | | | KRT5_1_011 | Context-specific genetic dependencies (175) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SF767_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-176 | 3852 | | KRT5 | TRCN0000083882 | -1.08308888507195 | none | | | KRT5_1_011 | Context-specific genetic dependencies (176) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SJSA1_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-177 | 3852 | | KRT5 | TRCN0000083882 | 0.908499830124357 | none | | | KRT5_1_011 | Context-specific genetic dependencies (177) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKCO1_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-178 | 3852 | | KRT5 | TRCN0000083882 | -0.461259705488104 | none | | | KRT5_1_011 | Context-specific genetic dependencies (178) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKMEL5_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-179 | 3852 | | KRT5 | TRCN0000083882 | -0.817234771634627 | none | | | KRT5_1_011 | Context-specific genetic dependencies (179) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKMM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-18 | 3852 | | KRT5 | TRCN0000083882 | -0.285322375189105 | none | | | KRT5_1_011 | Context-specific genetic dependencies (18) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | C2BBE1_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-180 | 3852 | | KRT5 | TRCN0000083882 | 2.19414843421687 | Increased shRNA abundance (Z-score > 2) | | | KRT5_1_011 | Context-specific genetic dependencies (180) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKNO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-181 | 3852 | | KRT5 | TRCN0000083882 | -0.718568566200466 | none | | | KRT5_1_011 | Context-specific genetic dependencies (181) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKOV3_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-182 | 3852 | | KRT5 | TRCN0000083882 | -2.01222679297088 | Decreased shRNA abundance (Z-score < -2) | | | KRT5_1_011 | Context-specific genetic dependencies (182) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKRC20_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-183 | 3852 | | KRT5 | TRCN0000083882 | 0.0552174713988256 | none | | | KRT5_1_011 | Context-specific genetic dependencies (183) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR20_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-184 | 3852 | | KRT5 | TRCN0000083882 | -0.0823321986565958 | none | | | KRT5_1_011 | Context-specific genetic dependencies (184) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR21_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-185 | 3852 | | KRT5 | TRCN0000083882 | -0.0171384600929555 | none | | | KRT5_1_011 | Context-specific genetic dependencies (185) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR23_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-186 | 3852 | | KRT5 | TRCN0000083882 | -0.97158243011897 | none | | | KRT5_1_011 | Context-specific genetic dependencies (186) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR24_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-187 | 3852 | | KRT5 | TRCN0000083882 | 0.40149221437772 | none | | | KRT5_1_011 | Context-specific genetic dependencies (187) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR25_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-188 | 3852 | | KRT5 | TRCN0000083882 | -0.107197279716698 | none | | | KRT5_1_011 | Context-specific genetic dependencies (188) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR26_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-189 | 3852 | | KRT5 | TRCN0000083882 | 0.232247360963236 | none | | | KRT5_1_011 | Context-specific genetic dependencies (189) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SNU1105_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-19 | 3852 | | KRT5 | TRCN0000083882 | 0.235341916298673 | none | | | KRT5_1_011 | Context-specific genetic dependencies (19) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | C32_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-190 | 3852 | | KRT5 | TRCN0000083882 | 0.30665696107076 | none | | | KRT5_1_011 | Context-specific genetic dependencies (190) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SNU840_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-191 | 3852 | | KRT5 | TRCN0000083882 | -0.494761285427065 | none | | | KRT5_1_011 | Context-specific genetic dependencies (191) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SNUC1_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-192 | 3852 | | KRT5 | TRCN0000083882 | 0.668851133170792 | none | | | KRT5_1_011 | Context-specific genetic dependencies (192) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SNUC2A_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-193 | 3852 | | KRT5 | TRCN0000083882 | -0.291316516522848 | none | | | KRT5_1_011 | Context-specific genetic dependencies (193) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SU8686_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-194 | 3852 | | KRT5 | TRCN0000083882 | 0.940038609509678 | none | | | KRT5_1_011 | Context-specific genetic dependencies (194) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SW1417_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-195 | 3852 | | KRT5 | TRCN0000083882 | 1.61992668336907 | none | | | KRT5_1_011 | Context-specific genetic dependencies (195) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SW1783_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-196 | 3852 | | KRT5 | TRCN0000083882 | -0.0789954125092865 | none | | | KRT5_1_011 | Context-specific genetic dependencies (196) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SW480_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-197 | 3852 | | KRT5 | TRCN0000083882 | -0.496442155530052 | none | | | KRT5_1_011 | Context-specific genetic dependencies (197) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SW48_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-198 | 3852 | | KRT5 | TRCN0000083882 | -0.868906561167788 | none | | | KRT5_1_011 | Context-specific genetic dependencies (198) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | T98G_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-199 | 3852 | | KRT5 | TRCN0000083882 | -0.839911457368324 | none | | | KRT5_1_011 | Context-specific genetic dependencies (199) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TC71_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-2 | 3852 | | KRT5 | TRCN0000083882 | 0.220331293829154 | none | | | KRT5_1_011 | Context-specific genetic dependencies (2) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | 697_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-20 | 3852 | | KRT5 | TRCN0000083882 | 1.04095849412069 | none | | | KRT5_1_011 | Context-specific genetic dependencies (20) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CADOES1_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-200 | 3852 | | KRT5 | TRCN0000083882 | 2.12966752472293 | Increased shRNA abundance (Z-score > 2) | | | KRT5_1_011 | Context-specific genetic dependencies (200) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TCCSUP_URINARY_TRACT | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-201 | 3852 | | KRT5 | TRCN0000083882 | -0.0716119098487591 | none | | | KRT5_1_011 | Context-specific genetic dependencies (201) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TE10_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-202 | 3852 | | KRT5 | TRCN0000083882 | 1.56781580322792 | none | | | KRT5_1_011 | Context-specific genetic dependencies (202) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TE15_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-203 | 3852 | | KRT5 | TRCN0000083882 | 0.587285263573295 | none | | | KRT5_1_011 | Context-specific genetic dependencies (203) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TE9_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-204 | 3852 | | KRT5 | TRCN0000083882 | 0.215996093274117 | none | | | KRT5_1_011 | Context-specific genetic dependencies (204) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-205 | 3852 | | KRT5 | TRCN0000083882 | 0.106701727400214 | none | | | KRT5_1_011 | Context-specific genetic dependencies (205) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TOV112D_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-206 | 3852 | | KRT5 | TRCN0000083882 | -0.383390943521342 | none | | | KRT5_1_011 | Context-specific genetic dependencies (206) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TOV21G_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-207 | 3852 | | KRT5 | TRCN0000083882 | -0.271572688865674 | none | | | KRT5_1_011 | Context-specific genetic dependencies (207) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TT_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-208 | 3852 | | KRT5 | TRCN0000083882 | 0.273680676669719 | none | | | KRT5_1_011 | Context-specific genetic dependencies (208) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TYKNU_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-209 | 3852 | | KRT5 | TRCN0000083882 | 0.55383006289488 | none | | | KRT5_1_011 | Context-specific genetic dependencies (209) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | U178_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-21 | 3852 | | KRT5 | TRCN0000083882 | -0.117899294087635 | none | | | KRT5_1_011 | Context-specific genetic dependencies (21) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAL120_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-210 | 3852 | | KRT5 | TRCN0000083882 | 0.118541419991115 | none | | | KRT5_1_011 | Context-specific genetic dependencies (210) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | U251MG_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-211 | 3852 | | KRT5 | TRCN0000083882 | -0.108923394804836 | none | | | KRT5_1_011 | Context-specific genetic dependencies (211) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | U343_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-212 | 3852 | | KRT5 | TRCN0000083882 | 0.0855837881187725 | none | | | KRT5_1_011 | Context-specific genetic dependencies (212) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | U87MG_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-213 | 3852 | | KRT5 | TRCN0000083882 | -1.00874305644767 | none | | | KRT5_1_011 | Context-specific genetic dependencies (213) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | UOK101_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-214 | 3852 | | KRT5 | TRCN0000083882 | -0.674055818830462 | none | | | KRT5_1_011 | Context-specific genetic dependencies (214) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | VCAP_PROSTATE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-215 | 3852 | | KRT5 | TRCN0000083882 | 0.25652287087977 | none | | | KRT5_1_011 | Context-specific genetic dependencies (215) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | YKG1_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-216 | 3852 | | KRT5 | TRCN0000083882 | -0.127358016596387 | none | | | KRT5_1_011 | Context-specific genetic dependencies (216) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | ZR7530_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-22 | 3852 | | KRT5 | TRCN0000083882 | 0.79072469718214 | none | | | KRT5_1_011 | Context-specific genetic dependencies (22) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAL51_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-23 | 3852 | | KRT5 | TRCN0000083882 | 0.821527499877696 | none | | | KRT5_1_011 | Context-specific genetic dependencies (23) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CALU1_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-24 | 3852 | | KRT5 | TRCN0000083882 | -0.194266527494228 | none | | | KRT5_1_011 | Context-specific genetic dependencies (24) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAOV3_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-25 | 3852 | | KRT5 | TRCN0000083882 | 0.611421761738792 | none | | | KRT5_1_011 | Context-specific genetic dependencies (25) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAOV4_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-26 | 3852 | | KRT5 | TRCN0000083882 | -0.973931640490093 | none | | | KRT5_1_011 | Context-specific genetic dependencies (26) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAS1_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-27 | 3852 | | KRT5 | TRCN0000083882 | -1.13065270722063 | none | | | KRT5_1_011 | Context-specific genetic dependencies (27) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CFPAC1_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-28 | 3852 | | KRT5 | TRCN0000083882 | 0.635626694519712 | none | | | KRT5_1_011 | Context-specific genetic dependencies (28) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CH157MN_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-29 | 3852 | | KRT5 | TRCN0000083882 | -0.290176695782696 | none | | | KRT5_1_011 | Context-specific genetic dependencies (29) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COLO205_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-3 | 3852 | | KRT5 | TRCN0000083882 | 0.651823769051127 | none | | | KRT5_1_011 | Context-specific genetic dependencies (3) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | 786O_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-30 | 3852 | | KRT5 | TRCN0000083882 | 1.05435378239886 | none | | | KRT5_1_011 | Context-specific genetic dependencies (30) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COLO704_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-31 | 3852 | | KRT5 | TRCN0000083882 | 0.603850851577091 | none | | | KRT5_1_011 | Context-specific genetic dependencies (31) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COLO741_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-32 | 3852 | | KRT5 | TRCN0000083882 | -0.201595584935854 | none | | | KRT5_1_011 | Context-specific genetic dependencies (32) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COLO783_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-33 | 3852 | | KRT5 | TRCN0000083882 | -0.176593508614303 | none | | | KRT5_1_011 | Context-specific genetic dependencies (33) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CORL23_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-34 | 3852 | | KRT5 | TRCN0000083882 | 0.585404761001003 | none | | | KRT5_1_011 | Context-specific genetic dependencies (34) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COV362_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-35 | 3852 | | KRT5 | TRCN0000083882 | -0.885758112601416 | none | | | KRT5_1_011 | Context-specific genetic dependencies (35) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COV434_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-36 | 3852 | | KRT5 | TRCN0000083882 | 0.537092821214825 | none | | | KRT5_1_011 | Context-specific genetic dependencies (36) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COV504_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-37 | 3852 | | KRT5 | TRCN0000083882 | 0.335923912872933 | none | | | KRT5_1_011 | Context-specific genetic dependencies (37) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COV644_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-38 | 3852 | | KRT5 | TRCN0000083882 | -0.708206582386465 | none | | | KRT5_1_011 | Context-specific genetic dependencies (38) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | DBTRG05MG_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-39 | 3852 | | KRT5 | TRCN0000083882 | 0.0571056618376753 | none | | | KRT5_1_011 | Context-specific genetic dependencies (39) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | DKMG_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-4 | 3852 | | KRT5 | TRCN0000083882 | 0.53058863404568 | none | | | KRT5_1_011 | Context-specific genetic dependencies (4) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A1207_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-40 | 3852 | | KRT5 | TRCN0000083882 | 1.30697417878632 | none | | | KRT5_1_011 | Context-specific genetic dependencies (40) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | DLD1_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-41 | 3852 | | KRT5 | TRCN0000083882 | 0.562236051807603 | none | | | KRT5_1_011 | Context-specific genetic dependencies (41) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EFE184_ENDOMETRIUM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-42 | 3852 | | KRT5 | TRCN0000083882 | 1.03913533547108 | none | | | KRT5_1_011 | Context-specific genetic dependencies (42) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EFM19_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-43 | 3852 | | KRT5 | TRCN0000083882 | -0.49401795695234 | none | | | KRT5_1_011 | Context-specific genetic dependencies (43) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EFO21_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-44 | 3852 | | KRT5 | TRCN0000083882 | 0.160864133636923 | none | | | KRT5_1_011 | Context-specific genetic dependencies (44) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EFO27_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-45 | 3852 | | KRT5 | TRCN0000083882 | -0.430352087344125 | none | | | KRT5_1_011 | Context-specific genetic dependencies (45) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EW8_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-46 | 3852 | | KRT5 | TRCN0000083882 | 0.278602801725739 | none | | | KRT5_1_011 | Context-specific genetic dependencies (46) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EWS502_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-47 | 3852 | | KRT5 | TRCN0000083882 | -0.1744048612267 | none | | | KRT5_1_011 | Context-specific genetic dependencies (47) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | F36P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-48 | 3852 | | KRT5 | TRCN0000083882 | -0.238981049853725 | none | | | KRT5_1_011 | Context-specific genetic dependencies (48) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | GB1_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-49 | 3852 | | KRT5 | TRCN0000083882 | -0.260983976003516 | none | | | KRT5_1_011 | Context-specific genetic dependencies (49) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | GP2D_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-5 | 3852 | | KRT5 | TRCN0000083882 | -0.453457025054275 | none | | | KRT5_1_011 | Context-specific genetic dependencies (5) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A172_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-50 | 3852 | | KRT5 | TRCN0000083882 | -0.826437021873785 | none | | | KRT5_1_011 | Context-specific genetic dependencies (50) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC1187_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-51 | 3852 | | KRT5 | TRCN0000083882 | -0.148243051330305 | none | | | KRT5_1_011 | Context-specific genetic dependencies (51) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC1395_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-52 | 3852 | | KRT5 | TRCN0000083882 | 0.722495301583141 | none | | | KRT5_1_011 | Context-specific genetic dependencies (52) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC1954_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-53 | 3852 | | KRT5 | TRCN0000083882 | -1.11980701796648 | none | | | KRT5_1_011 | Context-specific genetic dependencies (53) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC2218_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-54 | 3852 | | KRT5 | TRCN0000083882 | 0.963094899408495 | none | | | KRT5_1_011 | Context-specific genetic dependencies (54) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC2814_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-55 | 3852 | | KRT5 | TRCN0000083882 | -0.521702846641385 | none | | | KRT5_1_011 | Context-specific genetic dependencies (55) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC364_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-56 | 3852 | | KRT5 | TRCN0000083882 | 0.470949694146589 | none | | | KRT5_1_011 | Context-specific genetic dependencies (56) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC44_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-57 | 3852 | | KRT5 | TRCN0000083882 | 0.358449487918059 | none | | | KRT5_1_011 | Context-specific genetic dependencies (57) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC70_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-58 | 3852 | | KRT5 | TRCN0000083882 | 1.11594216360806 | none | | | KRT5_1_011 | Context-specific genetic dependencies (58) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC827GR5_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-59 | 3852 | | KRT5 | TRCN0000083882 | 0.0311875951203454 | none | | | KRT5_1_011 | Context-specific genetic dependencies (59) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC827_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-6 | 3852 | | KRT5 | TRCN0000083882 | -0.670149500404875 | none | | | KRT5_1_011 | Context-specific genetic dependencies (6) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A204_SOFT_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-60 | 3852 | | KRT5 | TRCN0000083882 | -0.952730899104905 | none | | | KRT5_1_011 | Context-specific genetic dependencies (60) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCT116_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-61 | 3852 | | KRT5 | TRCN0000083882 | 0.429431181754973 | none | | | KRT5_1_011 | Context-specific genetic dependencies (61) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HEC1A_ENDOMETRIUM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-62 | 3852 | | KRT5 | TRCN0000083882 | -0.236456656949562 | none | | | KRT5_1_011 | Context-specific genetic dependencies (62) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HEYA8_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-63 | 3852 | | KRT5 | TRCN0000083882 | -1.39968695077031 | none | | | KRT5_1_011 | Context-specific genetic dependencies (63) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-64 | 3852 | | KRT5 | TRCN0000083882 | -0.111291887857653 | none | | | KRT5_1_011 | Context-specific genetic dependencies (64) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HLF_LIVER | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-65 | 3852 | | KRT5 | TRCN0000083882 | -0.0875891870149797 | none | | | KRT5_1_011 | Context-specific genetic dependencies (65) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HNT34_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-66 | 3852 | | KRT5 | TRCN0000083882 | 0.937583407404536 | none | | | KRT5_1_011 | Context-specific genetic dependencies (66) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HPAC_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-67 | 3852 | | KRT5 | TRCN0000083882 | 1.20385783289055 | none | | | KRT5_1_011 | Context-specific genetic dependencies (67) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HPAFII_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-68 | 3852 | | KRT5 | TRCN0000083882 | 0.818204072973914 | none | | | KRT5_1_011 | Context-specific genetic dependencies (68) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HS683_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-69 | 3852 | | KRT5 | TRCN0000083882 | 0.547741398611655 | none | | | KRT5_1_011 | Context-specific genetic dependencies (69) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HS766T_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-7 | 3852 | | KRT5 | TRCN0000083882 | 0.592837037503463 | none | | | KRT5_1_011 | Context-specific genetic dependencies (7) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A2058_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-70 | 3852 | | KRT5 | TRCN0000083882 | -0.882698215680789 | none | | | KRT5_1_011 | Context-specific genetic dependencies (70) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HS944T_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-71 | 3852 | | KRT5 | TRCN0000083882 | -1.64304069528237 | Decreased shRNA abundance (Z-score < -2) | | | KRT5_1_011 | Context-specific genetic dependencies (71) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HT1197_URINARY_TRACT | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-72 | 3852 | | KRT5 | TRCN0000083882 | 1.24150002213922 | none | | | KRT5_1_011 | Context-specific genetic dependencies (72) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HT29_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-73 | 3852 | | KRT5 | TRCN0000083882 | 0.978885903348936 | none | | | KRT5_1_011 | Context-specific genetic dependencies (73) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HT55_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-74 | 3852 | | KRT5 | TRCN0000083882 | 0.214368156022841 | none | | | KRT5_1_011 | Context-specific genetic dependencies (74) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HUG1N_STOMACH | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-75 | 3852 | | KRT5 | TRCN0000083882 | 0.599644664345549 | none | | | KRT5_1_011 | Context-specific genetic dependencies (75) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HUTU80_SMALL_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-76 | 3852 | | KRT5 | TRCN0000083882 | 0.203537716471208 | none | | | KRT5_1_011 | Context-specific genetic dependencies (76) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | IGR39_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-77 | 3852 | | KRT5 | TRCN0000083882 | 0.278268316515172 | none | | | KRT5_1_011 | Context-specific genetic dependencies (77) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | IGROV1_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-78 | 3852 | | KRT5 | TRCN0000083882 | -1.3300007254637 | none | | | KRT5_1_011 | Context-specific genetic dependencies (78) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | IOMMLEE_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-79 | 3852 | | KRT5 | TRCN0000083882 | 0.54876212043546 | none | | | KRT5_1_011 | Context-specific genetic dependencies (79) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | JHESOAD1_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-8 | 3852 | | KRT5 | TRCN0000083882 | -1.08949791913862 | none | | | KRT5_1_011 | Context-specific genetic dependencies (8) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A549_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-80 | 3852 | | KRT5 | TRCN0000083882 | 0.541822119453902 | none | | | KRT5_1_011 | Context-specific genetic dependencies (80) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | JHOC5_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-81 | 3852 | | KRT5 | TRCN0000083882 | -0.701534018336641 | none | | | KRT5_1_011 | Context-specific genetic dependencies (81) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | JHOM1_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-82 | 3852 | | KRT5 | TRCN0000083882 | 0.354733475697428 | none | | | KRT5_1_011 | Context-specific genetic dependencies (82) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-83 | 3852 | | KRT5 | TRCN0000083882 | 0.0216071270526606 | none | | | KRT5_1_011 | Context-specific genetic dependencies (83) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-84 | 3852 | | KRT5 | TRCN0000083882 | -1.43281636234952 | none | | | KRT5_1_011 | Context-specific genetic dependencies (84) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KALS1_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-85 | 3852 | | KRT5 | TRCN0000083882 | 0.805092857666583 | none | | | KRT5_1_011 | Context-specific genetic dependencies (85) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-86 | 3852 | | KRT5 | TRCN0000083882 | -0.357395494016036 | none | | | KRT5_1_011 | Context-specific genetic dependencies (86) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KM12_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-87 | 3852 | | KRT5 | TRCN0000083882 | 0.151732586563978 | none | | | KRT5_1_011 | Context-specific genetic dependencies (87) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-88 | 3852 | | KRT5 | TRCN0000083882 | -0.0521453495100651 | none | | | KRT5_1_011 | Context-specific genetic dependencies (88) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KNS60_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-89 | 3852 | | KRT5 | TRCN0000083882 | -0.00449633067625304 | none | | | KRT5_1_011 | Context-specific genetic dependencies (89) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KNS81_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-9 | 3852 | | KRT5 | TRCN0000083882 | -0.650076984944702 | none | | | KRT5_1_011 | Context-specific genetic dependencies (9) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A673_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-90 | 3852 | | KRT5 | TRCN0000083882 | 0.754809043123614 | none | | | KRT5_1_011 | Context-specific genetic dependencies (90) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KP1NL_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-91 | 3852 | | KRT5 | TRCN0000083882 | 1.76254064099653 | Increased shRNA abundance (Z-score > 2) | | | KRT5_1_011 | Context-specific genetic dependencies (91) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KP2_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-92 | 3852 | | KRT5 | TRCN0000083882 | -1.10446178425579 | none | | | KRT5_1_011 | Context-specific genetic dependencies (92) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KP4_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-93 | 3852 | | KRT5 | TRCN0000083882 | 0.98966139355927 | none | | | KRT5_1_011 | Context-specific genetic dependencies (93) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KURAMOCHI_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-94 | 3852 | | KRT5 | TRCN0000083882 | 1.0566077136369 | none | | | KRT5_1_011 | Context-specific genetic dependencies (94) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KYSE150_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-95 | 3852 | | KRT5 | TRCN0000083882 | 1.60911716489692 | none | | | KRT5_1_011 | Context-specific genetic dependencies (95) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KYSE30_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-96 | 3852 | | KRT5 | TRCN0000083882 | -0.251059696460916 | none | | | KRT5_1_011 | Context-specific genetic dependencies (96) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KYSE450_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-97 | 3852 | | KRT5 | TRCN0000083882 | 1.2468117077777 | none | | | KRT5_1_011 | Context-specific genetic dependencies (97) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KYSE510_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-98 | 3852 | | KRT5 | TRCN0000083882 | 0.468176894931188 | none | | | KRT5_1_011 | Context-specific genetic dependencies (98) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | L33_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-99 | 3852 | | KRT5 | TRCN0000083882 | -0.081465612255746 | none | | | KRT5_1_011 | Context-specific genetic dependencies (99) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | | 3852 | 3852 | KRT5 | | -0.15000000000000002 | none | | | | | | | | | | | | | | | | | | | GR00376-A-1 | 3852 | 3852 | KRT5 | | 0.397578026 | none | | | | Mitigators of SS1P-induced immunotoxicity | Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity | Pasetto et al. | 2015 | 25713356 | Cell line | KB cells | Viability | Luminescence | Ambion Silencer Select Version 4 | Genome-wide | siRNA | RSA P-value | <0.001 | SS1P was applied in a "high dose", ≈EC90, 13 ng/ml. Cutoff was derived from data submitted to Pubchem (ID 1117281). Reagent sequences but no ID | GR00376-A-2 | 3852 | 3852 | KRT5 | | 0.172296506 | none | | | | Sensitizers of SS1P-induced immunotoxicity | Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity | Pasetto et al. | 2015 | 25713356 | Cell line | KB cells | Viability | Luminescence | Ambion Silencer Select Version 4 | Genome-wide | siRNA | RSA P-value | <0.001 | SS1P was applied in a "low dose", ≈EC30, 3 ng/ml. Cutoff was derived from data submitted to PubChem (ID 1117281). Reagent sequences but no ID | GR00378-A | 3852 | | KRT5 | | -1.57684612 | none | | | | Poliovirus vaccine production | Engineering Enhanced Vaccine Cell Lines To Eradicate Vaccine-Preventable Diseases: the Polio End Game | van der Sanden et al. | 2015 | 26581994 | Cell line | HEp-2C | Infection with Attenuated Poliovirus | ELISA | Dharmacon | Genome-wide | siRNA | Z-score | > | For infection, a single lot of the attenuated Sabin type 2 poliovirus was used for the screen. Gene IDs were not provided, only the gene name/symbol | | 3852 | NM_000424 | KRT5 | | 78.867 | none | | | | | | | | | | | | | | | | | | | GR00386-A-1 | 3852 | 3852 | KRT5 | | 107.704148146963 | none | | | | NOD2 stimulation by MDP | A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. | Warner et al. | 2014 | 25170077 | Cell line | HEK293 stably expressing NOD2 | Viability | Luminescence | Dharmacon | Genome-wide | siRNA | Percentage growth | Decreased: <70, increased: >120 | Reagent IDs not provided | GR00386-A-2 | 3852 | 3852 | KRT5 | | -661.3 | Increased IL-8 secretion | | | | MDP-induced IL-8 secretion | A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. | Warner et al. | 2014 | 25170077 | Cell line | HEK293 stably expressing NOD2 | IL-8 secretion | ELISA | Dharmacon | Genome-wide | siRNA | Percent inhibition of IL-8 secretion | Increased: <-300, Decreased: >60 | Concentration of IL-8 was measured from cell supernatants by sandwich ELISA. IL-8 values (pg/ml) were normalized to IL-8 secreted in cells treated with RIPK2-specific siRNA (100% inhibition) and non-targeting siRNA (0% inhibition). Secondary validating screen assessed 554 genes whose silencing affected MDP-induced IL-8 secretion in the primary screen. Final validated IL-8 regulators (positive or negative) are listed in the comments column. Reagent IDs not provided |