RNAi

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:5288
  • Symbol:PIK3C2G
  • Description:phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
DataSource: http://genomernai.dkfz.de/v16/genedetails/5288

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Stable_ID Entrez_ID Gene_ID Gene_Symbol Reagent_ID Score Phenotype Conditions Follow_Up Comment Screen_Title Publication_Title Authors Publication_Year Pubmed_ID Biosource Biomodel Assay Method Library Scope Reagent_Type Score_Type Cutoff Notes
GR00016-A 5288 5288 PIK3C2G np 1.93 none no Wnt/beta-catenin pathway regulation Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling. James et al. 2009 19471023 Cell line RKO Wnt/beta-catenin pathway reporter Luminescence rp Selected genes siRNA Z-score > 2
GR00053-A 5288 NM_004570 PIK3C2G np sp none no Genome stability A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Paulsen et al. 2009 19647519 Cell line HeLa gamma-H2AX phosphorylation and DNA content Fluorescence siARRAY human genome siRNA library Genome-wide siRNA p-value Complex criteria Confidence groupings from 4 to 1 (highest level of confidence in group 4)
GR00054-A 5288 NM_004570 PIK3C2G np 1.048 none no Combinatorial effect with paclitaxel Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Whitehurst et al. 2007 17429401 Cell line NCI-H1155 Viability (synthetic lethal) ATP level # G-005000-01 Genome-wide siRNA Paclitaxel/control ratio Complex criteria Additional information about 87 high-confidence hits
5288 5288 PIK3C2G np np Decreased cell migration yes deconvoluted validated siRNAs: 0/2
GR00055-A-3 5288 5288 PIK3C2G np np Decreased cell migration no Epithelial cell migration (3) Identification of genes that regulate epithelial cell migration using an siRNA screening approach. Simpson et al. 2008 19160483 Cell line MCF-10A overexpressing ERBB2 Cell migration and viability Microscopy and fluorescence SMARTpool siRNA library and MAR library Selected genes siRNA Area score and Alamar score Complex criteria
GR00056-A 5288 NM_004570 PIK3C2G np 1.073 none no Melanogenesis Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. Ganesan et al. 2008 19057677 Cell line MNT-1 Melanin protein expression and viability Absorbance and luminescence rp Genome-wide siRNA Normalized absorbance ratio > 2 standard deviations below mean Additional information about a secondary screen (retest to determine false-positive rate)
GR00057-A-1 5288 NM_004570 PIK3C2G M-006773-00 -0.52 none no Wnt/beta-catenin pathway regulation (1) A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. Tang et al. 2008 18621708 Cell line HeLa Wnt pathway reporter Luminescence Human siArray siRNA library Genome-wide siRNA Z-score > 4 Screen without Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries).
GR00057-A-2 5288 NM_004570 PIK3C2G M-006773-00 sp none no Wnt/beta-catenin pathway regulation (2) A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. Tang et al. 2008 18621708 Cell line HeLa Wnt pathway reporter Luminescence Human siArray siRNA library Genome-wide siRNA Complex, SP Complex criteria Screen with Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries).
GR00095-A 5288 NM_004570 PIK3C2G np np none p53 pathway components A large-scale RNAi screen in human cells identifies new components of the p53 pathway Berns et al. 2004 15042092 Cell line BJ-TERT-tsLT fibroblasts Proliferation Colony-forming cell assay Nki library Genome-wide shRNA np np
GR00098-A-1 5288 ENSG00000139144 PIK3C2G ENSG00000139144 sp none no Cell division (1) Genome-scale RNAi profiling of cell division in human tissue culture cells. Kittler et al. 2007 17994010 Cell line HeLa Cell number and DNA content Laser scanning cytometry rp Genome-wide esiRNA Complex, sp Complex criteria
GR00114-A 5288 PIK3C2G np -0.07 none 111% Combinatorial effect with Poly (ADP‐ribose)‐polymerase‐1 (PARP) A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor. Turner et al. 2008 18388863 Cell line CAL51 Viability Luminescence siARRAY SMARTpool Kinases siRNA Z-score < Growth rates (%) for vehicle-alone experiments are given in the comment field.
GR00123-A 5288 NM_004570 PIK3C2G 138423, 138422, 138421 np none Combinatorial effect with nutlin-3 An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors Brummelkamp et al. 2006 16474381 Cell line MCF-7 Viability Fluoresence Nki library Genome-wide shRNA log2 ratio np
GR00133-A-1 5288 5288 PIK3C2G np 0.021455 none no Salmonella enterica subspecies 1 serovar Typhimurium invasion (1) RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42. Misselwitz et al. 2011 21407211 Cell line HeLa Gentamycin protection invasion assay Fluorescence Druggable genome library V2.0 Druggable genes siRNA log2 median Complex criteria
GR00141-A 5288 NM_004570 PIK3C2G np np none no T cell chemotaxis Synaptotagmin-mediated vesicle fusion regulates cell migration. Colvin et al. 2010 20473299 Cell line SupT1 Cell migration Fluorescence shRNA Library Kinases, phosphatases and selected genes shRNA Chemotactic index > 1 standard deviation from plate mean by at least 2 shRNAs
GR00143-A 5288 PIK3C2G PIK3C2G s1 sp none no tau phosphorylation High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation. Azorsa et al. 2010 20067632 Cell line H4 overexpressing 4RON tau Total tau and 12E8 tau protein expression Fluorescence Validated human kinase siRNA Set 2.0 Kinases siRNA p-value Complex criteria
GR00143-A 5288 PIK3C2G PIK3C2G s2 sp none no tau phosphorylation High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation. Azorsa et al. 2010 20067632 Cell line H4 overexpressing 4RON tau Total tau and 12E8 tau protein expression Fluorescence Validated human kinase siRNA Set 2.0 Kinases siRNA p-value Complex criteria
GR00149-A-1 5288 5288 PIK3C2G 14879 79 none no Ciliogenesis and cilium length (1) Functional genomic screen for modulators of ciliogenesis and cilium length. Kim et al. 2010 20393563 Cell line htRPE Smoothed protein expression Fluorescence Human druggable genome siRNA library V3.1 Druggable genes siRNA Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1 5288 5288 PIK3C2G 14879 54.38 none no Ciliogenesis and cilium length (1) Functional genomic screen for modulators of ciliogenesis and cilium length. Kim et al. 2010 20393563 Cell line htRPE Smoothed protein expression Fluorescence Human druggable genome siRNA library V3.1 Druggable genes siRNA Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1 5288 5288 PIK3C2G 143925 30.89 none no Ciliogenesis and cilium length (1) Functional genomic screen for modulators of ciliogenesis and cilium length. Kim et al. 2010 20393563 Cell line htRPE Smoothed protein expression Fluorescence Human druggable genome siRNA library V3.1 Druggable genes siRNA Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1 5288 5288 PIK3C2G 143925 -17.47 none no Ciliogenesis and cilium length (1) Functional genomic screen for modulators of ciliogenesis and cilium length. Kim et al. 2010 20393563 Cell line htRPE Smoothed protein expression Fluorescence Human druggable genome siRNA library V3.1 Druggable genes siRNA Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1 5288 5288 PIK3C2G 143926 42.59 none no Ciliogenesis and cilium length (1) Functional genomic screen for modulators of ciliogenesis and cilium length. Kim et al. 2010 20393563 Cell line htRPE Smoothed protein expression Fluorescence Human druggable genome siRNA library V3.1 Druggable genes siRNA Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1 5288 5288 PIK3C2G 143926 np none no Ciliogenesis and cilium length (1) Functional genomic screen for modulators of ciliogenesis and cilium length. Kim et al. 2010 20393563 Cell line htRPE Smoothed protein expression Fluorescence Human druggable genome siRNA library V3.1 Druggable genes siRNA Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1 5288 5288 PIK3C2G 143927 -59.15 none no Ciliogenesis and cilium length (1) Functional genomic screen for modulators of ciliogenesis and cilium length. Kim et al. 2010 20393563 Cell line htRPE Smoothed protein expression Fluorescence Human druggable genome siRNA library V3.1 Druggable genes siRNA Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1 5288 5288 PIK3C2G 143927 24.56 none no Ciliogenesis and cilium length (1) Functional genomic screen for modulators of ciliogenesis and cilium length. Kim et al. 2010 20393563 Cell line htRPE Smoothed protein expression Fluorescence Human druggable genome siRNA library V3.1 Druggable genes siRNA Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean
GR00151-A-1 5288 ENSG00000139144 PIK3C2G np -1.293 none no Homologous recombination DNA double-strand break repair (HR-DSBR) (1) A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. Słabicki et al. 2010 20613862 Cell line HeLa (HR-DSBR) DR-GFP reporter Flow cytometry Custom-made Genome-wide esiRNA Z-score < -2 OR > 2
GR00155-A 5288 5288 PIK3C2G PIK3C2G_1, PIK3C2G_2, PIK3C2G_3 1 Decreased CYP1A1 activity after TCDD stimulation no Aryl hydrocarbon receptor (AhR) transduction pathway regulation RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity. Gilot et al. 2011 21479225 Cell line MCF-7 TCDD-induced CYP1A1-related EROD activity and cell viability Fluorescence and methylene blue MISSION siRNA Human Kinase Panel library Kinases siRNA Z-score Top 150 for >
GR00173-A 5288 NM_004570 PIK3C2G np 44.4 Decreased viability yes Rhabdomyosarcoma cell growth Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for the treatment of pediatric rhabdomyosarcomas. Hu et al. 2009 19887553 Cell line RH30 Viability Fluorescence siRNA libraries (V2.0) Kinases and phosphatases siRNA Percentage growth inhibition np
GR00173-A 5288 NM_004570 PIK3C2G np 44.9 Decreased viability yes Rhabdomyosarcoma cell growth Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for the treatment of pediatric rhabdomyosarcomas. Hu et al. 2009 19887553 Cell line RH30 Viability Fluorescence siRNA libraries (V2.0) Kinases and phosphatases siRNA Percentage growth inhibition np
GR00180-A-1 5288 5288 PIK3C2G PL-50002 0.851 none no Hepatitis C virus replication (1) A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Tai et al. 2009 19286138 Cell line Huh7/Rep-Feo HCV replicon RNA copy number Luminescence siARRAY Human Genome siRNA Library Genome-wide siRNA q-value Complex criteria
GR00184-A-1 5288 NM_004570 PIK3C2G M-006773-00 -0.805888496022452 none no Self-renewal and pluripotency in human embryonic stem cells (1) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line hESC H1 POU5F1 protein expression Fluorescence SMARTpool siRNA library Genome-wide siRNA Z-score < -2
GR00195-A-1 5288 5288 PIK3C2G np sp Decreased influenza A/WSN/33 replication yes Influenza virus infection (1) Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication. Karlas et al. 2010 20081832 Cell line A549 and 293T Number of influenza A H1N1 (A/WSN/33) infected cells and viral polymerase protein expression Fluorescence and luminescence Hu_Genome 1.0 and Human Druggable Genome siRNA Set V2.0 Genome-wide siRNA Complex, sp Complex criteria Additional information about a secondary screen with influenza A H5N1 strain (A/Vietnam/1203/2004)
GR00196-A-1 5288 ENSG00000139144 np sp none no TP53 interactions (1) A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly. Krastev et al. 2011 21642980 Cell line HCT116 ( wildtype and TP53 knockout) TP53 protein expression and viability Fluorescence rp Genome-wide esiRNA Complex, sp Complex criteria
GR00197-A-1 5288 5288 PIK3C2G M-006773-00 1.907253999 none no Human papillomavirus oncogene expression regulation (1) Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. Smith et al. 2010 20133580 Cell line C33A/BE2/18LCR c4 HPV18 LCR reporter activity Luminescence Human siGENOME SMARTpool library Genome-wide siRNA Z-score > Author-submitted data. Phenotype strength according to Z-scores: weak: 2 - 3; moderate: 3 - 5; strong: > 5
GR00210-A 5288 5288 PIK3C2G np sp Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, decreased FA abundance, increased peripheral FA formation no clusters: MC4, DC6, CC-NE Focal adhesion formation Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown. Winograd-Katz et al. 2009 19667130 Cell line HeLa paxillin protein expression Fluorescence SMARTpool siARRAY siRNA Libraries Kinases, phosphatases and selected genes siRNA Z-score > 3.5 OR < -3.5
GR00221-A-1 5288 PIK3C2G TRCN0000002338 -2.41 Decreased viability yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 5288 PIK3C2G TRCN0000002341 -0.97 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 5288 PIK3C2G TRCN0000002337 0.01 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 5288 PIK3C2G TRCN0000002340 0.45 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 5288 PIK3C2G TRCN0000002339 0.84 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 5288 PIK3C2G TRCN0000002339 -1.61 Decreased viability yes essential gene Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 5288 PIK3C2G TRCN0000002338 -1.53 Decreased viability yes essential gene Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 5288 PIK3C2G TRCN0000002337 -1.28 Decreased viability yes essential gene Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 5288 PIK3C2G TRCN0000002341 -0.01 none yes essential gene Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 5288 PIK3C2G TRCN0000002340 0.93 none yes essential gene Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 5288 PIK3C2G TRCN0000002341 -0.95 none yes Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 5288 PIK3C2G TRCN0000002338 -0.75 none yes Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 5288 PIK3C2G TRCN0000002337 0.12 none yes Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 5288 PIK3C2G TRCN0000002340 0.38 none yes Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 5288 PIK3C2G TRCN0000002339 1.47 none yes Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 5288 PIK3C2G TRCN0000002339 -1.41 Decreased viability no essential gene Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 5288 PIK3C2G TRCN0000002341 -1.18 Decreased viability no essential gene Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 5288 PIK3C2G TRCN0000002340 -0.43 none no essential gene Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 5288 PIK3C2G TRCN0000002337 0.11 none no essential gene Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 5288 PIK3C2G TRCN0000002338 0.83 none no essential gene Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00225-A 5288 PIK3C2G PIK3C2G_A -1.327406 none 10nM gemcitabine no Combinatorial effect with gemcitabine Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. Azorsa et al. 2009 19519883 Cell line MIAPaCa-2 Viability (synthetic lethal) Luminescence Validated kinase siRNA library version 1.0 Kinases siRNA log2 ratio 1.65 SD below mean ratio level
GR00225-A 5288 PIK3C2G PIK3C2G_B -1.408846 none 10nM gemcitabine no Combinatorial effect with gemcitabine Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. Azorsa et al. 2009 19519883 Cell line MIAPaCa-2 Viability (synthetic lethal) Luminescence Validated kinase siRNA library version 1.0 Kinases siRNA log2 ratio 1.65 SD below mean ratio level
GR00225-A 5288 PIK3C2G PIK3C2G_A -0.140838 none 5nM gemcitabine no Combinatorial effect with gemcitabine Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. Azorsa et al. 2009 19519883 Cell line MIAPaCa-2 Viability (synthetic lethal) Luminescence Validated kinase siRNA library version 1.0 Kinases siRNA log2 ratio 1.65 SD below mean ratio level
GR00225-A 5288 PIK3C2G PIK3C2G_B -0.08832 none 5nM gemcitabine no Combinatorial effect with gemcitabine Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. Azorsa et al. 2009 19519883 Cell line MIAPaCa-2 Viability (synthetic lethal) Luminescence Validated kinase siRNA library version 1.0 Kinases siRNA log2 ratio 1.65 SD below mean ratio level
5288 NM_004570 PIK3C2G np 0.925985 none no
GR00231-A 5288 NM_004570 PIK3C2G M-006773-00 -0.198 none yes Cell proliferation Time-resolved human kinome RNAi screen identifies a network regulating mitotic-events as early regulators of cell proliferation. Zhang et al. 2011 21765947 Cell line HeLa Viability Electrical impedance Human siARRAY - Protein Kinase and Cell Cycle libraries Kinases and selected genes siRNA Z-score < -1.96 OR > 1.96 Additional information about cell titer blue cell viability screen
GR00234-A-1 5288 NM_004570 PIK3C2G np sp none no decreased vesicular stomatitis virus pseudoparticles (VSVpp) infection Hepatitis C virus (HCV) infection (1) EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Lupberger et al. 2011 21516087 Cell line Huh7 Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) protein expression Luminescence Human Kinase RNAi Set V2.0 Kinases siRNA Complex, sp Complex criteria
GR00236-A-1 5288 5288 PIK3C2G M-006773-00 0.24348090185393 Decreased homologous recombination repair frequency yes Homologous recombination DNA double-strand break repair (HR-DSBR) (1) A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Adamson et al. 2012 22344029 Cell line DR-U2OS (HR-DSBR) DR-GFP reporter and DNA content Fluorescence Human siGENOME siRNA (G-005000-05) Genome-wide siRNA Relative HR ratio < ~0.4 OR > 1.88 Cutoff values correspond 2 standard deviations from the screen-wide mean
5288 5288 PIK3C2G D-006773-01 0.87 none yes
5288 5288 PIK3C2G D-006773-02 0.35 Decreased homologous recombination repair frequency yes strong cutoff, siRNA has 7mer antisense seed(s) matching to human RAD51 3'UTR
5288 5288 PIK3C2G D-006773-03 0.93 none yes
5288 5288 PIK3C2G D-006773-04 1.08 none yes
GR00236-A-3 5288 5288 PIK3C2G s10514 0.52 Decreased homologous recombination repair frequency no weak cutoff Homologous recombination DNA double-strand break repair (HR-DSBR) (3) A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Adamson et al. 2012 22344029 Cell line DR-U2OS (HR-DSBR) DR-GFP reporter and DNA content Fluorescence Silencer Select Selected genes siRNA Relative HR ratio Strong: < ~0.4; weak: < ~0.59 Cutoff values correspond 2 standard deviations from the screen-wide mean (strong) or 1.5 SD (weak)
GR00236-A-3 5288 5288 PIK3C2G s10515 1.03 none no Homologous recombination DNA double-strand break repair (HR-DSBR) (3) A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Adamson et al. 2012 22344029 Cell line DR-U2OS (HR-DSBR) DR-GFP reporter and DNA content Fluorescence Silencer Select Selected genes siRNA Relative HR ratio Strong: < ~0.4; weak: < ~0.59 Cutoff values correspond 2 standard deviations from the screen-wide mean (strong) or 1.5 SD (weak)
GR00236-A-3 5288 5288 PIK3C2G s10516 1.64 none no Homologous recombination DNA double-strand break repair (HR-DSBR) (3) A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Adamson et al. 2012 22344029 Cell line DR-U2OS (HR-DSBR) DR-GFP reporter and DNA content Fluorescence Silencer Select Selected genes siRNA Relative HR ratio Strong: < ~0.4; weak: < ~0.59 Cutoff values correspond 2 standard deviations from the screen-wide mean (strong) or 1.5 SD (weak)
GR00240-S-1 5288 NM_004570 PIK3C2G M-006773-00 1.34 none yes TRAIL-induced apoptosis (1) A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. Kranz and Boutros 2014 24442637 Cell line U251MG Viability Luminescence SMART-pool siRNA Genome-wide siRNA Z-score > 4 Author-submitted data
GR00240-S-2 5288 NM_004570 PIK3C2G M-006773-00 -1.35 none no Z-score -0.0085 TRAIL-induced apoptosis (2) A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. Kranz and Boutros 2014 24442637 Cell line U251MG Viability (synthetic lethal) Luminescence SMART-pool siRNA Genome-wide siRNA Differential score > 3.6 AND viability Z-score < 4 Author-submitted data. Z-scores from viability screen (1) are considered in score interpretation for this screen.
GR00242-A-1 5288 NM_004570 PIK3C2G np sp none no Selective autophagy regulation (1) Image-based genome-wide siRNA screen identifies selective autophagy factors. Orvedahl et al. 2011 22020285 Cell line HeLa/GFP-LC3 Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression Fluorescence siGenome Genome-wide siRNA Z-score Complex criteria
GR00247-A-1 5288 PIK3C2G np sp none rank: 14934 Regulation of FOXO1 nuclear localization (1) Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain. Senapedis et al. 2011 21460183 Cell line U2OS EGFP-FOXO1a protein expression and DNA content Fluorescence Human Genome library Genome-wide siRNA Complex, sp Complex criteria
GR00248-A 5288 NM_004570 PIK3C2G PIK3C2G_siRNA1 1.811 none Human cytomegalovirus (HCMV) strain AD169 replication Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Terry et al. 2012 22315427 Cell line MRC5 Human cytomegalovirus (HCMV) IE1 protein expression Fluorescence Mission siRNA Human Kinase Panel Kinases siRNA Z-score >
GR00248-A 5288 NM_004570 PIK3C2G PIK3C2G_siRNA2 0.876 none Human cytomegalovirus (HCMV) strain AD169 replication Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Terry et al. 2012 22315427 Cell line MRC5 Human cytomegalovirus (HCMV) IE1 protein expression Fluorescence Mission siRNA Human Kinase Panel Kinases siRNA Z-score >
GR00248-A 5288 NM_004570 PIK3C2G PIK3C2G_siRNA3 -1.775 none Human cytomegalovirus (HCMV) strain AD169 replication Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Terry et al. 2012 22315427 Cell line MRC5 Human cytomegalovirus (HCMV) IE1 protein expression Fluorescence Mission siRNA Human Kinase Panel Kinases siRNA Z-score >
GR00249-S 5288 5288 PIK3C2G J-006773-05 -0.51037 none no number of cells compared to control (%): 97.89 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 5288 5288 PIK3C2G M-006773-01 -0.19379 none no number of cells compared to control (%): 66.30 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 5288 5288 PIK3C2G s10514 -0.62504 none no number of cells compared to control (%): 75.42 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 5288 5288 PIK3C2G s10515 0.82559 Decreased viability no number of cells compared to control (%): 48.86 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 5288 5288 PIK3C2G s10516 -0.8085 none no number of cells compared to control (%): 85.48 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00253-A 5288 NM_004570 PIK3C2G np -0.642 none hepcidin regulation Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Mleczko-Sanecka et al. 2014 24385536 Cell line Huh7 hepcidin::fluc mRNA expression Luminescence siGenome siARRAY SMARTpool Genome-wide siRNA Z-score > Cutoff <
GR00255-A-1 5288 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002340, TRCN0000002341 0.361008763 none Negative genetic interactions (1) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.0 HCT116 BLM-/- and HCT116 BLM+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-2 5288 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002340, TRCN0000002341 -1.340999894 Negative genetic interaction between MUS81-/- and MUS81+/+ Negative genetic interactions (2) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.0 HCT116 MUS81-/- and HCT116 MUS81+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-3 5288 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002340, TRCN0000002341 -0.211090978 none Negative genetic interactions (3) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.2 HCT116 PTEN-/- and HCT116 PTEN+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-4 5288 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002340, TRCN0000002341 0.687696167 none Negative genetic interactions (4) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.2 HCT116 PTTG1-/- and HCT116 PTTG1+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-5 5288 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002340, TRCN0000002341 -0.418878873 none Negative genetic interactions (5) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -0.8 HCT116 KRASG13D/- and HCT116 KRAS+/- cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00256-A 5288 NM_004570 PIK3C2G np sp none Kinase-mediated spindle orientation ABL1 regulates spindle orientation in adherent cells and mammalian skin. Matsumara et al. 2012 22252550 Cell line HeLa beta-tubulin protein expression and DNA content Fluorescence Silencer Kinase siRNA library (AM80010V3) Kinases siRNA Complex, sp Complex criteria HeLa cells stably expressing GFP-H2B (HeLa-GH2B) used. Additional information about secondary screens.
GR00293-A 5288 PIK3C2G np 0.376 none Combinatorial effect with paclitaxel Mechanisms Promoting Escape from Mitotic Stress−Induced Tumor Cell Death Sinnott et al. 2014 24860162 Cell line HCC366 Viability Luminescence Thermo-Fisher Genome-wide siRNA Z-score < -2.5 Final hits according to the author are indicated in the comment.
GR00297-A 5288 PIK3C2G TRCN0000195256 -0.07 none Glucose limitation response Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides Birsoy et al. 2014 24670634 Cell line Jurkat shRNA abundance in high and low glucose Deep sequencing TRC Selected genes shRNA Log2 ratio < -0.75
GR00297-A 5288 PIK3C2G TRCN0000002340 -0.2 none Glucose limitation response Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides Birsoy et al. 2014 24670634 Cell line Jurkat shRNA abundance in high and low glucose Deep sequencing TRC Selected genes shRNA Log2 ratio < -0.75
GR00297-A 5288 PIK3C2G TRCN0000002337 0.66 none Glucose limitation response Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides Birsoy et al. 2014 24670634 Cell line Jurkat shRNA abundance in high and low glucose Deep sequencing TRC Selected genes shRNA Log2 ratio < -0.75
GR00297-A 5288 PIK3C2G TRCN0000002338 1.15 none Glucose limitation response Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides Birsoy et al. 2014 24670634 Cell line Jurkat shRNA abundance in high and low glucose Deep sequencing TRC Selected genes shRNA Log2 ratio < -0.75
GR00297-A 5288 PIK3C2G TRCN0000196876 0.03 none Glucose limitation response Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides Birsoy et al. 2014 24670634 Cell line Jurkat shRNA abundance in high and low glucose Deep sequencing TRC Selected genes shRNA Log2 ratio < -0.75
GR00297-A 5288 PIK3C2G TRCN0000002341 -0.98 Decreased shRNA abundance Glucose limitation response Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides Birsoy et al. 2014 24670634 Cell line Jurkat shRNA abundance in high and low glucose Deep sequencing TRC Selected genes shRNA Log2 ratio < -0.75
GR00297-A 5288 PIK3C2G TRCN0000002339 -0.07 none Glucose limitation response Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides Birsoy et al. 2014 24670634 Cell line Jurkat shRNA abundance in high and low glucose Deep sequencing TRC Selected genes shRNA Log2 ratio < -0.75
GR00297-A 5288 PIK3C2G TRCN0000196621 -0.01 none Glucose limitation response Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides Birsoy et al. 2014 24670634 Cell line Jurkat shRNA abundance in high and low glucose Deep sequencing TRC Selected genes shRNA Log2 ratio < -0.75
GR00297-A 5288 PIK3C2G TRCN0000196544 0.76 none Glucose limitation response Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides Birsoy et al. 2014 24670634 Cell line Jurkat shRNA abundance in high and low glucose Deep sequencing TRC Selected genes shRNA Log2 ratio < -0.75
GR00300-A 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000196544, TRCN0000196876, TRCN0000196621, TRCN0000195256, TRCN0000002340, TRCN0000002341, TRCN0000002339 0 none Combinatorial effect with RAF inhibitor PLX4720 A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition. Whittaker et al. 2013 23288408 Cell line A375 shRNA abundance Sequencing TRC Genome-wide shRNA Number of shRNAs ranked Top1000 > 2 The A375 cell line used here harbours the BRAF V600E mutation and is therefore sensitive to RAF inhibitors.
GR00303-A 5288 NM_004570 PIK3C2G np -0.84 none Clear cell renal cell carcinoma (ccRCC) survival regulation Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target Gerlinger et al. 2012 22362593 Cell line VHL-deficient RCC4 Proliferation and Viability Fluorescence np Genome-wide siRNA Z-score < In the phenotype data duplicates were in the original document, which have been removed.
GR00310-A-1 5288 5288 PIK3C2G np 0.01 none Sindbis virus (SINV) infection (1) Genome-Wide RNAi Screen Identifies Novel Host Proteins Required for Alphavirus Entry Ooi et al. 2013 24367265 Cell line U2OS Sindbis virus (SINV) reporter Luminescence Ambion Silencer V3 Genome-wide siRNA Z-score < -3 OR > 2
5288 5288 PIK3C2G np 11.5 none 92,5% viability
GR00313-A 5288 NM_004570 PIK3C2G np -0.04 none TNF-alpha pathway regulation A Genome-Wide RNA Interference Screen Identifies Caspase 4 as a Factor Required for Tumor Necrosis Factor Alpha Signaling. Nickles et al. 2012 22733992 Cell line HEK293T NFkappaB pathway reporter Luminescence Qiagen Genome-wide siRNA Z-score < Additional filters were a reduction in firefly luciferase levels by at least 50% compared to the mean of the experiment and a concomitant reduction of renilla luciferase expression of not more than 30%.
GR00318-A 5288 5288 PIK3C2G np 1.174 none siRNA set: kinase Huntingtin toxicity A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington’s Disease Miller et al. 2012 23209424 Cell line HEK293T Caspase 3/7 activity Fluorescence Dharmacon Selected genes siRNA Sum of normalized caspase 3/7 activity mean and standard error < 0.683 HEK293T cells were cotransfected with mutant Huntingtin fused to GFP (Htt1-558141Q-GFP).
GR00342-S-1 5288 PIK3C2G M-006773-00 0.5467902929343187 none Viability of Mesenchymal Stem Cells (MSC) (1) Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening Erdmann et al. 2015 26120366 Primary cells Bone marrow derived MSC Viability Luminescence Kinase siGENOME SMARTpool library Kinases and phosphatases siRNA Z-score > Donor 1, MSC preparation 1 (MSC1a)
GR00342-S-2 5288 PIK3C2G M-006773-00 1.090477165365169 none Viability of Mesenchymal Stem Cells (MSC) (2) Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening Erdmann et al. 2015 26120366 Primary cells Bone marrow derived MSC Viability Luminescence Kinase siGENOME SMARTpool library Kinases and phosphatases siRNA Z-score > Donor 1, MSC preparation 2 (MSC1b)
GR00342-S-3 5288 PIK3C2G M-006773-00 1.2881226959603227 none Viability of Mesenchymal Stem Cells (MSC) (3) Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening Erdmann et al. 2015 26120366 Primary cells Bone marrow derived MSC Viability Luminescence Kinase siGENOME SMARTpool library Kinases and phosphatases siRNA Z-score > Donor 2, MSC preparation 1 (MSC2)
GR00343-S 5288 5288 PIK3C2G TRCN0000002338 -1.1099999999999994 shRNA abundance <= 50% Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 5288 5288 PIK3C2G TRCN0000002340 1.0324999999999989 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 5288 5288 PIK3C2G TRCN0000002337 -1.0149999999999988 shRNA abundance <= 50% Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 5288 5288 PIK3C2G TRCN0000002341 -0.13250000000000028 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 5288 5288 PIK3C2G TRCN0000002339 -0.7274999999999991 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00355-A 5288 5288 PIK3C2G np 1.057449442 Increased epidermal growth factor receptor (EGFR) surface abundance PIP3-mediated epidermal growth factor (EGFR) endocytosis PIP3 induces the recycling of receptor tyrosine kinases Laketa et al. 2014 24425787 Cell line HeLa Kyoto Epidermal growth factor (EGFR) surface abundance Fluorescence Qiagen Selected genes siRNA Deviation score < -1 OR > 1 HeLa Kyoto cells were stably transfected with EGFR-EYFP. Reagent Sequences (but no reagent ID) available in Table S4.
GR00363-A 5288 5288 PIK3C2G SI02223606, SI03067932, SI02223599, 143927, 143925, SI03100307, 143926 sp Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis strong Endocytosis regulation Systems survey of endocytosis by multiparametric image analysis. Collinet et al. 2010 20190736 Cell line HeLa Transferrin (TF) and epidermal growth factor (EGF) subcellular localisation, DNA content Fluorescence Ambion, Qiagen and esiRNA library (Kittler et al.) Genome-wide siRNA Complex, sp Complex criteria Two hit categories: "strong" (maximum of Prob Chi2, Prob Chi2 EGF, Prob Chi2 Tfn > 0.95) and "weak but specific" (maximum of Prob Chi2, Prob Chi2 EGF, Prob Chi2 Tfn < 0.95 but Phenoscore > 0.95). Additional information about secondary screens with kinase and phospatase libraries.
GR00366-A-1 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.436477241068044 none PIK3C2G_1_11101 Context-specific genetic dependencies (1) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line 22RV1_PROSTATE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-10 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.163983306039683 none PIK3C2G_1_11101 Context-specific genetic dependencies (10) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line ACHN_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-100 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.0181194458531587 none PIK3C2G_1_11101 Context-specific genetic dependencies (100) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LAMA84_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-101 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.585938389403196 none PIK3C2G_1_11101 Context-specific genetic dependencies (101) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LK2_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-102 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.872303668570389 none PIK3C2G_1_11101 Context-specific genetic dependencies (102) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN215_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-103 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.295192227441205 none PIK3C2G_1_11101 Context-specific genetic dependencies (103) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN229_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-104 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.347732196814661 none PIK3C2G_1_11101 Context-specific genetic dependencies (104) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN235_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-105 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 1.00096010460579 none PIK3C2G_1_11101 Context-specific genetic dependencies (105) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN319_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-106 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.0995836207168516 none PIK3C2G_1_11101 Context-specific genetic dependencies (106) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN340_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-107 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.400086347211276 none PIK3C2G_1_11101 Context-specific genetic dependencies (107) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN382_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-108 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.569371795052374 none PIK3C2G_1_11101 Context-specific genetic dependencies (108) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN428_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-109 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.101257429961404 none PIK3C2G_1_11101 Context-specific genetic dependencies (109) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN443_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-11 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.233805614389217 none PIK3C2G_1_11101 Context-specific genetic dependencies (11) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line AGS_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-110 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.662352629987203 none PIK3C2G_1_11101 Context-specific genetic dependencies (110) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN464_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-111 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.14497025012739 none PIK3C2G_1_11101 Context-specific genetic dependencies (111) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LNZ308_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-112 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.0816506615457411 none PIK3C2G_1_11101 Context-specific genetic dependencies (112) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LOVO_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-113 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.808653708349513 none PIK3C2G_1_11101 Context-specific genetic dependencies (113) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LS411N_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-114 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.238422545005225 none PIK3C2G_1_11101 Context-specific genetic dependencies (114) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LS513_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-115 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.0756324968064692 none PIK3C2G_1_11101 Context-specific genetic dependencies (115) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MCF7_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-116 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.821823083807907 none PIK3C2G_1_11101 Context-specific genetic dependencies (116) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MDAMB453_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-117 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.369120547076506 none PIK3C2G_1_11101 Context-specific genetic dependencies (117) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MIAPACA2_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-118 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.189992034481724 none PIK3C2G_1_11101 Context-specific genetic dependencies (118) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MKN7_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-119 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.547297147190857 none PIK3C2G_1_11101 Context-specific genetic dependencies (119) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-12 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.320442587790671 none PIK3C2G_1_11101 Context-specific genetic dependencies (12) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line AM38_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-120 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 1.12377286011467 none PIK3C2G_1_11101 Context-specific genetic dependencies (120) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-121 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.119362963930363 none PIK3C2G_1_11101 Context-specific genetic dependencies (121) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-122 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.763600455490814 none PIK3C2G_1_11101 Context-specific genetic dependencies (122) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MONOMAC6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-123 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.474132428837229 none PIK3C2G_1_11101 Context-specific genetic dependencies (123) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MV411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-124 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.451060270518207 none PIK3C2G_1_11101 Context-specific genetic dependencies (124) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-125 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.482087982476336 none PIK3C2G_1_11101 Context-specific genetic dependencies (125) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-126 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.0035338610299495 none PIK3C2G_1_11101 Context-specific genetic dependencies (126) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1299_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-127 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.110768385411613 none PIK3C2G_1_11101 Context-specific genetic dependencies (127) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1437_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-128 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.556200668647035 none PIK3C2G_1_11101 Context-specific genetic dependencies (128) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1650_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-129 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.584278415032678 none PIK3C2G_1_11101 Context-specific genetic dependencies (129) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1792_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-13 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.0766422171912427 none PIK3C2G_1_11101 Context-specific genetic dependencies (13) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line AML193_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-130 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.177643951945424 none PIK3C2G_1_11101 Context-specific genetic dependencies (130) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH196_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-131 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.436603156219367 none PIK3C2G_1_11101 Context-specific genetic dependencies (131) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1975_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-132 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 1.20482316380254 none PIK3C2G_1_11101 Context-specific genetic dependencies (132) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2052_PLEURA shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-133 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.223117884844601 none PIK3C2G_1_11101 Context-specific genetic dependencies (133) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2122_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-134 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.318496843267763 none PIK3C2G_1_11101 Context-specific genetic dependencies (134) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2171_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-135 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.204401835764954 none PIK3C2G_1_11101 Context-specific genetic dependencies (135) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH23_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-136 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.131413881514917 none PIK3C2G_1_11101 Context-specific genetic dependencies (136) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2452_PLEURA shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-137 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -1.27631412987164 none PIK3C2G_1_11101 Context-specific genetic dependencies (137) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH441_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-138 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.395698472121786 none PIK3C2G_1_11101 Context-specific genetic dependencies (138) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH508_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-139 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -1.38350192876173 Decreased shRNA abundance (Z-score < -2) PIK3C2G_1_11101 Context-specific genetic dependencies (139) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH660_PROSTATE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-14 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.0180299865075431 none PIK3C2G_1_11101 Context-specific genetic dependencies (14) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line ASPC1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-140 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.560392328970551 none PIK3C2G_1_11101 Context-specific genetic dependencies (140) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH661_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-141 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.0758157459502442 none PIK3C2G_1_11101 Context-specific genetic dependencies (141) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH716_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-142 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.107381734772757 none PIK3C2G_1_11101 Context-specific genetic dependencies (142) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH838_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-143 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.575800950884941 none PIK3C2G_1_11101 Context-specific genetic dependencies (143) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIN87_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-144 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.0311457917451388 none PIK3C2G_1_11101 Context-specific genetic dependencies (144) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NIHOVCAR3_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-145 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.817015536109427 none PIK3C2G_1_11101 Context-specific genetic dependencies (145) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NOMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-146 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 1.47080708341725 none PIK3C2G_1_11101 Context-specific genetic dependencies (146) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OAW42_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-147 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.65652897732173 none PIK3C2G_1_11101 Context-specific genetic dependencies (147) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-148 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 2.24637633252433 Increased shRNA abundance (Z-score > 2) PIK3C2G_1_11101 Context-specific genetic dependencies (148) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-149 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.673004476456646 none PIK3C2G_1_11101 Context-specific genetic dependencies (149) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-15 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.37215931744174 none PIK3C2G_1_11101 Context-specific genetic dependencies (15) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line BT20_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-150 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.577269794818932 none PIK3C2G_1_11101 Context-specific genetic dependencies (150) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OE33_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-151 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.76230098915325 none PIK3C2G_1_11101 Context-specific genetic dependencies (151) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OELE_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-152 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.655818468279917 none PIK3C2G_1_11101 Context-specific genetic dependencies (152) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-153 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.0551746063674777 none PIK3C2G_1_11101 Context-specific genetic dependencies (153) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OV7_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-154 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.44674322755936 none PIK3C2G_1_11101 Context-specific genetic dependencies (154) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OV90_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-155 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.327079265009915 none PIK3C2G_1_11101 Context-specific genetic dependencies (155) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OVCAR4_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-156 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.114362483951097 none PIK3C2G_1_11101 Context-specific genetic dependencies (156) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OVCAR8_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-157 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.0845409086997621 none PIK3C2G_1_11101 Context-specific genetic dependencies (157) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OVISE_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-158 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.48086002141333 none PIK3C2G_1_11101 Context-specific genetic dependencies (158) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PANC0327_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-159 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.382128495381501 none PIK3C2G_1_11101 Context-specific genetic dependencies (159) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PANC0813_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-16 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.603904107396869 none PIK3C2G_1_11101 Context-specific genetic dependencies (16) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line BT474_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-160 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.483497596213809 none PIK3C2G_1_11101 Context-specific genetic dependencies (160) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PANC1005_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-161 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.228335070937892 none PIK3C2G_1_11101 Context-specific genetic dependencies (161) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PLB985_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-162 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.35007533328924 none PIK3C2G_1_11101 Context-specific genetic dependencies (162) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PSN1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-163 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.259745313187819 none PIK3C2G_1_11101 Context-specific genetic dependencies (163) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line QGP1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-164 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.723431506157216 none PIK3C2G_1_11101 Context-specific genetic dependencies (164) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-165 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.439418786856143 none PIK3C2G_1_11101 Context-specific genetic dependencies (165) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RKN_SOFT_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-166 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.769997045631361 none PIK3C2G_1_11101 Context-specific genetic dependencies (166) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RKO_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-167 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 2.05664177326829 Increased shRNA abundance (Z-score > 2) PIK3C2G_1_11101 Context-specific genetic dependencies (167) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RMGI_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-168 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.141202570166622 none PIK3C2G_1_11101 Context-specific genetic dependencies (168) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RMUGS_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-169 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.140931658965938 none PIK3C2G_1_11101 Context-specific genetic dependencies (169) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-17 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.743678881700838 none PIK3C2G_1_11101 Context-specific genetic dependencies (17) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line BXPC3_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-170 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.196491124842322 none PIK3C2G_1_11101 Context-specific genetic dependencies (170) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RT112_URINARY_TRACT shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-171 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.038094404815079 none PIK3C2G_1_11101 Context-specific genetic dependencies (171) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-172 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.738469286702648 none PIK3C2G_1_11101 Context-specific genetic dependencies (172) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF126_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-173 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.257654329600478 none PIK3C2G_1_11101 Context-specific genetic dependencies (173) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF172_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-174 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.421534144903644 none PIK3C2G_1_11101 Context-specific genetic dependencies (174) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF295_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-175 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.559680742632833 none PIK3C2G_1_11101 Context-specific genetic dependencies (175) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF767_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-176 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.0510340876797795 none PIK3C2G_1_11101 Context-specific genetic dependencies (176) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SJSA1_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-177 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 3.49103872069099 Increased shRNA abundance (Z-score > 2) PIK3C2G_1_11101 Context-specific genetic dependencies (177) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKCO1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-178 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.101879284624486 none PIK3C2G_1_11101 Context-specific genetic dependencies (178) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKMEL5_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-179 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.530286441532749 none PIK3C2G_1_11101 Context-specific genetic dependencies (179) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKMM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-18 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.901400551444004 none PIK3C2G_1_11101 Context-specific genetic dependencies (18) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line C2BBE1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-180 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.289558681609132 none PIK3C2G_1_11101 Context-specific genetic dependencies (180) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKNO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-181 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.674858047205347 none PIK3C2G_1_11101 Context-specific genetic dependencies (181) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKOV3_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-182 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.179454887444998 none PIK3C2G_1_11101 Context-specific genetic dependencies (182) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKRC20_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-183 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.772382177658899 none PIK3C2G_1_11101 Context-specific genetic dependencies (183) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR20_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-184 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.502123137631458 none PIK3C2G_1_11101 Context-specific genetic dependencies (184) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR21_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-185 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.876556699855866 none PIK3C2G_1_11101 Context-specific genetic dependencies (185) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR23_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-186 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.631576374609271 none PIK3C2G_1_11101 Context-specific genetic dependencies (186) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR24_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-187 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.218488156859683 none PIK3C2G_1_11101 Context-specific genetic dependencies (187) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR25_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-188 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.17701848813209 none PIK3C2G_1_11101 Context-specific genetic dependencies (188) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR26_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-189 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.475585466913153 none PIK3C2G_1_11101 Context-specific genetic dependencies (189) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNU1105_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-19 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.169370351092416 none PIK3C2G_1_11101 Context-specific genetic dependencies (19) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line C32_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-190 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 1.12386059521953 none PIK3C2G_1_11101 Context-specific genetic dependencies (190) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNU840_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-191 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.292117756168063 none PIK3C2G_1_11101 Context-specific genetic dependencies (191) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNUC1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-192 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.506808961698545 none PIK3C2G_1_11101 Context-specific genetic dependencies (192) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNUC2A_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-193 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.343644248879277 none PIK3C2G_1_11101 Context-specific genetic dependencies (193) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SU8686_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-194 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.281675598446178 none PIK3C2G_1_11101 Context-specific genetic dependencies (194) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW1417_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-195 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.451936212687636 none PIK3C2G_1_11101 Context-specific genetic dependencies (195) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW1783_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-196 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.83032032946277 none PIK3C2G_1_11101 Context-specific genetic dependencies (196) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW480_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-197 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.290797368670832 none PIK3C2G_1_11101 Context-specific genetic dependencies (197) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW48_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-198 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -1.11048754563134 none PIK3C2G_1_11101 Context-specific genetic dependencies (198) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line T98G_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-199 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.314521292367989 none PIK3C2G_1_11101 Context-specific genetic dependencies (199) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TC71_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-2 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.728200172527076 none PIK3C2G_1_11101 Context-specific genetic dependencies (2) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line 697_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-20 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.209440716797133 none PIK3C2G_1_11101 Context-specific genetic dependencies (20) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CADOES1_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-200 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 1.76429148562313 Increased shRNA abundance (Z-score > 2) PIK3C2G_1_11101 Context-specific genetic dependencies (200) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TCCSUP_URINARY_TRACT shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-201 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.202596645209381 none PIK3C2G_1_11101 Context-specific genetic dependencies (201) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TE10_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-202 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.299503182126193 none PIK3C2G_1_11101 Context-specific genetic dependencies (202) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TE15_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-203 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.295455086725356 none PIK3C2G_1_11101 Context-specific genetic dependencies (203) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TE9_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-204 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 1.72830263563892 Increased shRNA abundance (Z-score > 2) PIK3C2G_1_11101 Context-specific genetic dependencies (204) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-205 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.497603565853037 none PIK3C2G_1_11101 Context-specific genetic dependencies (205) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TOV112D_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-206 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.824348627007515 none PIK3C2G_1_11101 Context-specific genetic dependencies (206) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TOV21G_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-207 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 1.8673813031827 Increased shRNA abundance (Z-score > 2) PIK3C2G_1_11101 Context-specific genetic dependencies (207) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TT_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-208 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.731052220297403 none PIK3C2G_1_11101 Context-specific genetic dependencies (208) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TYKNU_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-209 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.586653967181679 none PIK3C2G_1_11101 Context-specific genetic dependencies (209) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U178_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-21 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.976694595985407 none PIK3C2G_1_11101 Context-specific genetic dependencies (21) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAL120_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-210 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.749222843833615 none PIK3C2G_1_11101 Context-specific genetic dependencies (210) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U251MG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-211 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.0530622296839805 none PIK3C2G_1_11101 Context-specific genetic dependencies (211) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U343_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-212 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.332167827363896 none PIK3C2G_1_11101 Context-specific genetic dependencies (212) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U87MG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-213 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.803933078940359 none PIK3C2G_1_11101 Context-specific genetic dependencies (213) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line UOK101_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-214 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.0992095327434351 none PIK3C2G_1_11101 Context-specific genetic dependencies (214) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line VCAP_PROSTATE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-215 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -1.16790884508349 none PIK3C2G_1_11101 Context-specific genetic dependencies (215) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line YKG1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-216 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 1.1223705955786 none PIK3C2G_1_11101 Context-specific genetic dependencies (216) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line ZR7530_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-22 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.0212187977787234 none PIK3C2G_1_11101 Context-specific genetic dependencies (22) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAL51_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-23 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.0657673898807523 none PIK3C2G_1_11101 Context-specific genetic dependencies (23) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CALU1_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-24 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.187643739382399 none PIK3C2G_1_11101 Context-specific genetic dependencies (24) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAOV3_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-25 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.216572908872418 none PIK3C2G_1_11101 Context-specific genetic dependencies (25) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAOV4_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-26 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.433892077417619 none PIK3C2G_1_11101 Context-specific genetic dependencies (26) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAS1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-27 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.14426308819753 none PIK3C2G_1_11101 Context-specific genetic dependencies (27) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CFPAC1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-28 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.616200876560216 none PIK3C2G_1_11101 Context-specific genetic dependencies (28) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CH157MN_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-29 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -1.07667428860242 none PIK3C2G_1_11101 Context-specific genetic dependencies (29) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO205_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-3 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.604923579572061 none PIK3C2G_1_11101 Context-specific genetic dependencies (3) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line 786O_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-30 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.565867767542981 none PIK3C2G_1_11101 Context-specific genetic dependencies (30) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO704_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-31 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.699917698891694 none PIK3C2G_1_11101 Context-specific genetic dependencies (31) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO741_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-32 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.268476061891701 none PIK3C2G_1_11101 Context-specific genetic dependencies (32) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO783_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-33 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.529611787150751 none PIK3C2G_1_11101 Context-specific genetic dependencies (33) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CORL23_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-34 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.182141693825067 none PIK3C2G_1_11101 Context-specific genetic dependencies (34) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV362_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-35 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.675722845474055 none PIK3C2G_1_11101 Context-specific genetic dependencies (35) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV434_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-36 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.39274681569158 none PIK3C2G_1_11101 Context-specific genetic dependencies (36) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV504_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-37 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.122064261265222 none PIK3C2G_1_11101 Context-specific genetic dependencies (37) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV644_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-38 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.125591174913052 none PIK3C2G_1_11101 Context-specific genetic dependencies (38) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line DBTRG05MG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-39 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.361079610524474 none PIK3C2G_1_11101 Context-specific genetic dependencies (39) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line DKMG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-4 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.166475026229717 none PIK3C2G_1_11101 Context-specific genetic dependencies (4) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A1207_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-40 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.81407079069789 none PIK3C2G_1_11101 Context-specific genetic dependencies (40) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line DLD1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-41 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.23400225228704 none PIK3C2G_1_11101 Context-specific genetic dependencies (41) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFE184_ENDOMETRIUM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-42 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.465404605313157 none PIK3C2G_1_11101 Context-specific genetic dependencies (42) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFM19_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-43 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.847864486106922 none PIK3C2G_1_11101 Context-specific genetic dependencies (43) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFO21_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-44 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.333543461204287 none PIK3C2G_1_11101 Context-specific genetic dependencies (44) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFO27_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-45 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.293340942193894 none PIK3C2G_1_11101 Context-specific genetic dependencies (45) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EW8_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-46 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.0742846736959786 none PIK3C2G_1_11101 Context-specific genetic dependencies (46) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EWS502_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-47 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.0481678418639751 none PIK3C2G_1_11101 Context-specific genetic dependencies (47) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line F36P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-48 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.100495204493653 none PIK3C2G_1_11101 Context-specific genetic dependencies (48) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line GB1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-49 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 2.42833700107387 Increased shRNA abundance (Z-score > 2) PIK3C2G_1_11101 Context-specific genetic dependencies (49) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line GP2D_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-5 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.00647881401481055 none PIK3C2G_1_11101 Context-specific genetic dependencies (5) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A172_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-50 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.252559325478282 none PIK3C2G_1_11101 Context-specific genetic dependencies (50) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC1187_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-51 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.242823607217294 none PIK3C2G_1_11101 Context-specific genetic dependencies (51) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC1395_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-52 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.220184809735464 none PIK3C2G_1_11101 Context-specific genetic dependencies (52) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC1954_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-53 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.57235189764663 none PIK3C2G_1_11101 Context-specific genetic dependencies (53) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC2218_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-54 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.543622197195695 none PIK3C2G_1_11101 Context-specific genetic dependencies (54) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC2814_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-55 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.10387925905356 none PIK3C2G_1_11101 Context-specific genetic dependencies (55) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC364_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-56 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.871555599964687 none PIK3C2G_1_11101 Context-specific genetic dependencies (56) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC44_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-57 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.642609731681612 none PIK3C2G_1_11101 Context-specific genetic dependencies (57) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC70_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-58 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.897248955447013 none PIK3C2G_1_11101 Context-specific genetic dependencies (58) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC827GR5_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-59 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.163452335379246 none PIK3C2G_1_11101 Context-specific genetic dependencies (59) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC827_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-6 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.11146559067388 none PIK3C2G_1_11101 Context-specific genetic dependencies (6) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A204_SOFT_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-60 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 1.84257430152593 Increased shRNA abundance (Z-score > 2) PIK3C2G_1_11101 Context-specific genetic dependencies (60) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCT116_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-61 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.388702335541169 none PIK3C2G_1_11101 Context-specific genetic dependencies (61) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HEC1A_ENDOMETRIUM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-62 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.208310100950013 none PIK3C2G_1_11101 Context-specific genetic dependencies (62) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HEYA8_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-63 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.0390852070012836 none PIK3C2G_1_11101 Context-specific genetic dependencies (63) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-64 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.16435082477009 none PIK3C2G_1_11101 Context-specific genetic dependencies (64) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HLF_LIVER shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-65 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.180947690774854 none PIK3C2G_1_11101 Context-specific genetic dependencies (65) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HNT34_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-66 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.841577873998203 none PIK3C2G_1_11101 Context-specific genetic dependencies (66) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HPAC_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-67 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.230527197073892 none PIK3C2G_1_11101 Context-specific genetic dependencies (67) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HPAFII_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-68 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.543009491969635 none PIK3C2G_1_11101 Context-specific genetic dependencies (68) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HS683_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-69 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.0869218985083416 none PIK3C2G_1_11101 Context-specific genetic dependencies (69) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HS766T_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-7 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.530432332303674 none PIK3C2G_1_11101 Context-specific genetic dependencies (7) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A2058_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-70 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.17428881948368 none PIK3C2G_1_11101 Context-specific genetic dependencies (70) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HS944T_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-71 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.600505783026567 none PIK3C2G_1_11101 Context-specific genetic dependencies (71) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HT1197_URINARY_TRACT shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-72 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.959009627018477 none PIK3C2G_1_11101 Context-specific genetic dependencies (72) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HT29_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-73 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -1.40172556172798 Decreased shRNA abundance (Z-score < -2) PIK3C2G_1_11101 Context-specific genetic dependencies (73) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HT55_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-74 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.244715300228506 none PIK3C2G_1_11101 Context-specific genetic dependencies (74) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HUG1N_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-75 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.143627906207248 none PIK3C2G_1_11101 Context-specific genetic dependencies (75) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HUTU80_SMALL_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-76 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.794144295992943 none PIK3C2G_1_11101 Context-specific genetic dependencies (76) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line IGR39_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-77 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 1.17980641891002 none PIK3C2G_1_11101 Context-specific genetic dependencies (77) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line IGROV1_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-78 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.556563601734544 none PIK3C2G_1_11101 Context-specific genetic dependencies (78) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line IOMMLEE_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-79 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.106847870950482 none PIK3C2G_1_11101 Context-specific genetic dependencies (79) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JHESOAD1_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-8 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.331877055292636 none PIK3C2G_1_11101 Context-specific genetic dependencies (8) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A549_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-80 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.681417086893267 none PIK3C2G_1_11101 Context-specific genetic dependencies (80) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JHOC5_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-81 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.307000788115012 none PIK3C2G_1_11101 Context-specific genetic dependencies (81) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JHOM1_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-82 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.499374920242237 none PIK3C2G_1_11101 Context-specific genetic dependencies (82) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-83 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.876081910479632 none PIK3C2G_1_11101 Context-specific genetic dependencies (83) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-84 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.353896758885367 none PIK3C2G_1_11101 Context-specific genetic dependencies (84) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KALS1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-85 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 2.16007117142857 Increased shRNA abundance (Z-score > 2) PIK3C2G_1_11101 Context-specific genetic dependencies (85) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-86 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.653004867423257 none PIK3C2G_1_11101 Context-specific genetic dependencies (86) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KM12_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-87 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.0129031892071041 none PIK3C2G_1_11101 Context-specific genetic dependencies (87) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-88 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.396801798970541 none PIK3C2G_1_11101 Context-specific genetic dependencies (88) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KNS60_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-89 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.36637911620073 none PIK3C2G_1_11101 Context-specific genetic dependencies (89) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KNS81_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-9 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.76718720209563 none PIK3C2G_1_11101 Context-specific genetic dependencies (9) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A673_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-90 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.918175547277238 none PIK3C2G_1_11101 Context-specific genetic dependencies (90) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KP1NL_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-91 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 2.26799731070457 Increased shRNA abundance (Z-score > 2) PIK3C2G_1_11101 Context-specific genetic dependencies (91) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KP2_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-92 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -1.02726064986418 none PIK3C2G_1_11101 Context-specific genetic dependencies (92) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KP4_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-93 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.236847624188759 none PIK3C2G_1_11101 Context-specific genetic dependencies (93) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KURAMOCHI_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-94 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.755032794809866 none PIK3C2G_1_11101 Context-specific genetic dependencies (94) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE150_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-95 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 1.26627761523062 none PIK3C2G_1_11101 Context-specific genetic dependencies (95) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE30_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-96 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.852247072269185 none PIK3C2G_1_11101 Context-specific genetic dependencies (96) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE450_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-97 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.649930998575035 none PIK3C2G_1_11101 Context-specific genetic dependencies (97) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE510_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-98 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 -0.499951096326222 none PIK3C2G_1_11101 Context-specific genetic dependencies (98) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line L33_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-99 5288 PIK3C2G TRCN0000002337, TRCN0000002338, TRCN0000002339, TRCN0000002341 0.889223212395393 none PIK3C2G_1_11101 Context-specific genetic dependencies (99) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
5288 5288 PIK3C2G -0.060000000000000026 none
GR00371-A-1 5288 5288 PIK3C2G 0.489671008581 none Dharmacon Nanog expression in absence of bFGF and TGFbeta Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-2 5288 PIK3C2G 5288 -0.0546264400833 none Dharmacon Nanog expression in presence of TGFbeta inhibitor Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-3 5288 5288 PIK3C2G 0.0308192140289 none Dharmacon Nanog expression in presence of MEK inhibitor Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-4 5288 5288 PIK3C2G 0.137705465902 none Dharmacon Nanog expression in presence of PI3K inhibitor Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-5 5288 5288 PIK3C2G 0.26217007197 none Dharmacon Nanog expression in presence of retinoic acid Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00376-A-1 5288 5288 PIK3C2G 0.374404894 none Mitigators of SS1P-induced immunotoxicity Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity Pasetto et al. 2015 25713356 Cell line KB cells Viability Luminescence Ambion Silencer Select Version 4 Genome-wide siRNA RSA P-value <0.001 SS1P was applied in a "high dose", ≈EC90, 13 ng/ml. Cutoff was derived from data submitted to Pubchem (ID 1117281). Reagent sequences but no ID
GR00376-A-2 5288 5288 PIK3C2G 0.060803546 none Sensitizers of SS1P-induced immunotoxicity Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity Pasetto et al. 2015 25713356 Cell line KB cells Viability Luminescence Ambion Silencer Select Version 4 Genome-wide siRNA RSA P-value <0.001 SS1P was applied in a "low dose", ≈EC30, 3 ng/ml. Cutoff was derived from data submitted to PubChem (ID 1117281). Reagent sequences but no ID
GR00378-A 5288 PIK3C2G -0.793406285 none Poliovirus vaccine production Engineering Enhanced Vaccine Cell Lines To Eradicate Vaccine-Preventable Diseases: the Polio End Game van der Sanden et al. 2015 26581994 Cell line HEp-2C Infection with Attenuated Poliovirus ELISA Dharmacon Genome-wide siRNA Z-score > For infection, a single lot of the attenuated Sabin type 2 poliovirus was used for the screen. Gene IDs were not provided, only the gene name/symbol
5288 NM_004570 PIK3C2G 45.484 none
GR00386-A-1 5288 5288 PIK3C2G 103.261384501401 none NOD2 stimulation by MDP A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. Warner et al. 2014 25170077 Cell line HEK293 stably expressing NOD2 Viability Luminescence Dharmacon Genome-wide siRNA Percentage growth Decreased: <70, increased: >120 Reagent IDs not provided
GR00386-A-2 5288 5288 PIK3C2G -27.4 none MDP-induced IL-8 secretion A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. Warner et al. 2014 25170077 Cell line HEK293 stably expressing NOD2 IL-8 secretion ELISA Dharmacon Genome-wide siRNA Percent inhibition of IL-8 secretion Increased: <-300, Decreased: >60 Concentration of IL-8 was measured from cell supernatants by sandwich ELISA. IL-8 values (pg/ml) were normalized to IL-8 secreted in cells treated with RIPK2-specific siRNA (100% inhibition) and non-targeting siRNA (0% inhibition). Secondary validating screen assessed 554 genes whose silencing affected MDP-induced IL-8 secretion in the primary screen. Final validated IL-8 regulators (positive or negative) are listed in the comments column. Reagent IDs not provided