| GR00016-A | 7046 | 7046 | TGFBR1 | np | 1.53 | none | | no | | Wnt/beta-catenin pathway regulation | Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling. | James et al. | 2009 | 19471023 | Cell line | RKO | Wnt/beta-catenin pathway reporter | Luminescence | rp | Selected genes | siRNA | Z-score | > 2 | | GR00053-A | 7046 | NM_004612 | TGFBR1 | np | sp | none | | no | | Genome stability | A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. | Paulsen et al. | 2009 | 19647519 | Cell line | HeLa | gamma-H2AX phosphorylation and DNA content | Fluorescence | siARRAY human genome siRNA library | Genome-wide | siRNA | p-value | Complex criteria | Confidence groupings from 4 to 1 (highest level of confidence in group 4) | GR00054-A | 7046 | NM_004612 | TGFBR1 | np | 1.002 | none | | no | | Combinatorial effect with paclitaxel | Synthetic lethal screen identification of chemosensitizer loci in cancer cells. | Whitehurst et al. | 2007 | 17429401 | Cell line | NCI-H1155 | Viability (synthetic lethal) | ATP level | # G-005000-01 | Genome-wide | siRNA | Paclitaxel/control ratio | Complex criteria | Additional information about 87 high-confidence hits | | 7046 | 7046 | TGFBR1 | np | np | none | | no | | | | | | | | | | | | | | | | | GR00056-A | 7046 | NM_004612 | TGFBR1 | np | 1.087 | none | | no | | Melanogenesis | Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. | Ganesan et al. | 2008 | 19057677 | Cell line | MNT-1 | Melanin protein expression and viability | Absorbance and luminescence | rp | Genome-wide | siRNA | Normalized absorbance ratio | > 2 standard deviations below mean | Additional information about a secondary screen (retest to determine false-positive rate) | GR00057-A-1 | 7046 | NM_004612 | TGFBR1 | M-003929-01 | -0.4 | none | | no | | Wnt/beta-catenin pathway regulation (1) | A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. | Tang et al. | 2008 | 18621708 | Cell line | HeLa | Wnt pathway reporter | Luminescence | Human siArray siRNA library | Genome-wide | siRNA | Z-score | > 4 | Screen without Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries). | GR00057-A-2 | 7046 | NM_004612 | TGFBR1 | M-003929-01 | sp | Downregulation of Wnt pathway after Wnt3A stimulation | | yes | | Wnt/beta-catenin pathway regulation (2) | A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. | Tang et al. | 2008 | 18621708 | Cell line | HeLa | Wnt pathway reporter | Luminescence | Human siArray siRNA library | Genome-wide | siRNA | Complex, SP | Complex criteria | Screen with Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries). | GR00095-A | 7046 | NM_004612 | TGFBR1 | np | np | none | | | | p53 pathway components | A large-scale RNAi screen in human cells identifies new components of the p53 pathway | Berns et al. | 2004 | 15042092 | Cell line | BJ-TERT-tsLT fibroblasts | Proliferation | Colony-forming cell assay | Nki library | Genome-wide | shRNA | np | np | | GR00098-A-1 | 7046 | ENSG00000106799 | TGFBR1 | ENSG00000106799 | sp | Increased G1 DNA content | | yes | G0/1 arrest, validated with resynthesized esiRNA | Cell division (1) | Genome-scale RNAi profiling of cell division in human tissue culture cells. | Kittler et al. | 2007 | 17994010 | Cell line | HeLa | Cell number and DNA content | Laser scanning cytometry | rp | Genome-wide | esiRNA | Complex, sp | Complex criteria | | GR00098-A-2 | 7046 | ENSG00000106799 | TGFBR1 | ENSG00000106799_2 | sp | G0/1 arrest | | yes | | Cell division (2) | Genome-scale RNAi profiling of cell division in human tissue culture cells. | Kittler et al. | 2007 | 17994010 | Cell line | HeLa | Cell number and DNA content | Laser scanning cytometry | rp | Selected genes | esiRNA | Complex, sp | Complex criteria | | GR00098-A-3 | 7046 | ENSG00000106799 | TGFBR1 | ENSG00000106799 | -2.4 | none | | yes | | Cell division (3) | Genome-scale RNAi profiling of cell division in human tissue culture cells. | Kittler et al. | 2007 | 17994010 | Cell line | HeLa | Histone H3 phosphorylation; alpha-tubulin and pericentrin protein expression | Fluorescence | rp | Selected genes | esiRNA | Mitotic index | > | | GR00098-A-4 | 7046 | ENSG00000106799 | TGFBR1 | ENSG00000106799 | -1.8 | none | | no | | Cell division (4) | Genome-scale RNAi profiling of cell division in human tissue culture cells. | Kittler et al. | 2007 | 17994010 | Cell line | HeLa | Cell size (forward scatter) | Flow cytometry | rp | Selected genes | esiRNA | Cell size | > | | GR00114-A | 7046 | | TGFBR1 | np | -1.11 | none | | | 121% | Combinatorial effect with Poly (ADP‐ribose)‐polymerase‐1 (PARP) | A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor. | Turner et al. | 2008 | 18388863 | Cell line | CAL51 | Viability | Luminescence | siARRAY SMARTpool | Kinases | siRNA | Z-score | < | Growth rates (%) for vehicle-alone experiments are given in the comment field. | GR00123-A | 7046 | NM_004612 | TGFBR1 | 103301, 103302, 103303 | np | none | | | | Combinatorial effect with nutlin-3 | An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors | Brummelkamp et al. | 2006 | 16474381 | Cell line | MCF-7 | Viability | Fluoresence | Nki library | Genome-wide | shRNA | log2 ratio | np | | GR00133-A-1 | 7046 | 7046 | TGFBR1 | np | -0.32382 | none | | no | | Salmonella enterica subspecies 1 serovar Typhimurium invasion (1) | RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42. | Misselwitz et al. | 2011 | 21407211 | Cell line | HeLa | Gentamycin protection invasion assay | Fluorescence | Druggable genome library V2.0 | Druggable genes | siRNA | log2 median | Complex criteria | | GR00143-A | 7046 | | TGFBR1 | TGFBR1 s1 | sp | none | | no | | tau phosphorylation | High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation. | Azorsa et al. | 2010 | 20067632 | Cell line | H4 overexpressing 4RON tau | Total tau and 12E8 tau protein expression | Fluorescence | Validated human kinase siRNA Set 2.0 | Kinases | siRNA | p-value | Complex criteria | | GR00143-A | 7046 | | TGFBR1 | TGFBR1 s2 | sp | none | | no | | tau phosphorylation | High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation. | Azorsa et al. | 2010 | 20067632 | Cell line | H4 overexpressing 4RON tau | Total tau and 12E8 tau protein expression | Fluorescence | Validated human kinase siRNA Set 2.0 | Kinases | siRNA | p-value | Complex criteria | | GR00149-A-1 | 7046 | 7046 | TGFBR1 | 556 | 19.15 | none | | no | | Ciliogenesis and cilium length (1) | Functional genomic screen for modulators of ciliogenesis and cilium length. | Kim et al. | 2010 | 20393563 | Cell line | htRPE | Smoothed protein expression | Fluorescence | Human druggable genome siRNA library V3.1 | Druggable genes | siRNA | Normalized percent inhibition | > 1.5 OR < -1.5 standard deviations from mean | | GR00149-A-1 | 7046 | 7046 | TGFBR1 | 556 | -4.54 | none | | no | | Ciliogenesis and cilium length (1) | Functional genomic screen for modulators of ciliogenesis and cilium length. | Kim et al. | 2010 | 20393563 | Cell line | htRPE | Smoothed protein expression | Fluorescence | Human druggable genome siRNA library V3.1 | Druggable genes | siRNA | Normalized percent inhibition | > 1.5 OR < -1.5 standard deviations from mean | | GR00149-A-1 | 7046 | 7046 | TGFBR1 | 103324 | 119.22 | none | | no | | Ciliogenesis and cilium length (1) | Functional genomic screen for modulators of ciliogenesis and cilium length. | Kim et al. | 2010 | 20393563 | Cell line | htRPE | Smoothed protein expression | Fluorescence | Human druggable genome siRNA library V3.1 | Druggable genes | siRNA | Normalized percent inhibition | > 1.5 OR < -1.5 standard deviations from mean | | GR00149-A-1 | 7046 | 7046 | TGFBR1 | 103324 | 54.85 | none | | no | | Ciliogenesis and cilium length (1) | Functional genomic screen for modulators of ciliogenesis and cilium length. | Kim et al. | 2010 | 20393563 | Cell line | htRPE | Smoothed protein expression | Fluorescence | Human druggable genome siRNA library V3.1 | Druggable genes | siRNA | Normalized percent inhibition | > 1.5 OR < -1.5 standard deviations from mean | | GR00149-A-1 | 7046 | 7046 | TGFBR1 | 103408 | -50.3 | none | | no | | Ciliogenesis and cilium length (1) | Functional genomic screen for modulators of ciliogenesis and cilium length. | Kim et al. | 2010 | 20393563 | Cell line | htRPE | Smoothed protein expression | Fluorescence | Human druggable genome siRNA library V3.1 | Druggable genes | siRNA | Normalized percent inhibition | > 1.5 OR < -1.5 standard deviations from mean | | GR00149-A-1 | 7046 | 7046 | TGFBR1 | 103408 | -14.25 | none | | no | | Ciliogenesis and cilium length (1) | Functional genomic screen for modulators of ciliogenesis and cilium length. | Kim et al. | 2010 | 20393563 | Cell line | htRPE | Smoothed protein expression | Fluorescence | Human druggable genome siRNA library V3.1 | Druggable genes | siRNA | Normalized percent inhibition | > 1.5 OR < -1.5 standard deviations from mean | | GR00151-A-1 | 7046 | ENSG00000106799 | TGFBR1 | np | -0.485 | none | | no | | Homologous recombination DNA double-strand break repair (HR-DSBR) (1) | A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. | Słabicki et al. | 2010 | 20613862 | Cell line | HeLa | (HR-DSBR) DR-GFP reporter | Flow cytometry | Custom-made | Genome-wide | esiRNA | Z-score | < -2 OR > 2 | | GR00155-A | 7046 | 7046 | TGFBR1 | TGFBR1_1, TGFBR1_2, TGFBR1_3 | np | none | | no | | Aryl hydrocarbon receptor (AhR) transduction pathway regulation | RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity. | Gilot et al. | 2011 | 21479225 | Cell line | MCF-7 | TCDD-induced CYP1A1-related EROD activity and cell viability | Fluorescence and methylene blue | MISSION siRNA Human Kinase Panel library | Kinases | siRNA | Z-score | Top 150 for > | | GR00180-A-1 | 7046 | 7046 | TGFBR1 | PL-50003 | 0.751 | none | | no | | Hepatitis C virus replication (1) | A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. | Tai et al. | 2009 | 19286138 | Cell line | Huh7/Rep-Feo | HCV replicon RNA copy number | Luminescence | siARRAY Human Genome siRNA Library | Genome-wide | siRNA | q-value | Complex criteria | | GR00184-A-1 | 7046 | NM_004612 | TGFBR1 | M-003929-01 | -0.586828395467596 | none | | no | | Self-renewal and pluripotency in human embryonic stem cells (1) | A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. | Chia et al. | 2010 | 20953172 | Cell line | hESC H1 | POU5F1 protein expression | Fluorescence | SMARTpool siRNA library | Genome-wide | siRNA | Z-score | < -2 | | GR00193-A-1 | 7046 | 7046 | TGFBR1 | TGFBR1 | 0.903959652175824 | none | | yes | Illumina gene expression above basal level (p < 0.05) | Therapeutic kinase targets in neuroblastoma (1) | RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. | Cole et al. | 2011 | 21289283 | Cell line | EBC1 | Substrate adherent cell growth | rp | Kinase siGenome library | Kinases | siRNA | Relative growth | 0.5 standard deviations below mean | | GR00193-A-2 | 7046 | 7046 | TGFBR1 | TGFBR1 | 0.448419450317125 | Decreased substrate adherent cell growth | | yes | Illumina gene expression above basal level (p < 0.05) | Therapeutic kinase targets in neuroblastoma (2) | RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. | Cole et al. | 2011 | 21289283 | Cell line | KELLY | Substrate adherent cell growth | rp | Kinase siGenome library | Kinases | siRNA | Relative growth | 0.5 standard deviations below mean | | GR00193-A-3 | 7046 | 7046 | TGFBR1 | TGFBR1 | 0.932122691735491 | none | | yes | Illumina gene expression above basal level (p < 0.05) | Therapeutic kinase targets in neuroblastoma (3) | RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. | Cole et al. | 2011 | 21289283 | Cell line | SKNAS | Substrate adherent cell growth | rp | Kinase siGenome library | Kinases | siRNA | Relative growth | 0.5 standard deviations below mean | | GR00193-A-4 | 7046 | 7046 | TGFBR1 | TGFBR1 | 1.01711667918747 | none | | no | Illumina gene expression above basal level (p < 0.05) | Therapeutic kinase targets in neuroblastoma (4) | RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. | Cole et al. | 2011 | 21289283 | Cell line | NLF | Substrate adherent cell growth | rp | Kinase siGenome library | Kinases | siRNA | Relative growth | 0.5 standard deviations below mean | | GR00196-A-1 | 7046 | ENSG00000106799 | | np | sp | none | | no | | TP53 interactions (1) | A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly. | Krastev et al. | 2011 | 21642980 | Cell line | HCT116 ( wildtype and TP53 knockout) | TP53 protein expression and viability | Fluorescence | rp | Genome-wide | esiRNA | Complex, sp | Complex criteria | | GR00197-A-1 | 7046 | 7046 | TGFBR1 | M-003929-01 | 1.645070134 | none | | no | | Human papillomavirus oncogene expression regulation (1) | Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. | Smith et al. | 2010 | 20133580 | Cell line | C33A/BE2/18LCR c4 | HPV18 LCR reporter activity | Luminescence | Human siGENOME SMARTpool library | Genome-wide | siRNA | Z-score | > | Author-submitted data. Phenotype strength according to Z-scores: weak: 2 - 3; moderate: 3 - 5; strong: > 5 | GR00206-A | 7046 | 7046 | TGFBR1 | np | np | none | | no | | Apoptosis regulation after Chlamydia trachomatis serovar L2 infection | HIF-1α is involved in mediating apoptosis resistance to Chlamydia trachomatis-infected cells. | Sharma et al. | 2011 | 21824245 | Cell line | HeLa | Cleaved cytokeratin-18 protein expression | Fluorescence | Custom-made | Apoptosis, cellular trafficking and cell signalling genes | siRNA | p-value | < | Author-reviewed data | GR00210-A | 7046 | 7046 | TGFBR1 | np | sp | none | | no | | Focal adhesion formation | Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown. | Winograd-Katz et al. | 2009 | 19667130 | Cell line | HeLa | paxillin protein expression | Fluorescence | SMARTpool siARRAY siRNA Libraries | Kinases, phosphatases and selected genes | siRNA | Z-score | > 3.5 OR < -3.5 | | | 7046 | NM_004612 | TGFBR1 | np | np | Increased colony dispersion (increased number of colonies and decreased number of cells per colony) | | yes | | | | | | | | | | | | | | | | | GR00221-A-1 | 7046 | | TGFBR1 | TRCN0000039776 | -1.22 | Decreased viability | | yes | | Proliferation of cells with active beta-catenin (1) | CK1epsilon is required for breast cancers dependent on beta-catenin activity. | Kim et al. | 2010 | 20126544 | Cell line | MCF-7 | Viability | Luminescence | TRC shRNA Library | Kinases | shRNA | B-score | < -1 | Essential gene: gene with B-score < -1 for > | GR00221-A-1 | 7046 | | TGFBR1 | TRCN0000039773 | -0.5 | none | | yes | | Proliferation of cells with active beta-catenin (1) | CK1epsilon is required for breast cancers dependent on beta-catenin activity. | Kim et al. | 2010 | 20126544 | Cell line | MCF-7 | Viability | Luminescence | TRC shRNA Library | Kinases | shRNA | B-score | < -1 | Essential gene: gene with B-score < -1 for > | GR00221-A-1 | 7046 | | TGFBR1 | TRCN0000039777 | -0.29 | none | | yes | | Proliferation of cells with active beta-catenin (1) | CK1epsilon is required for breast cancers dependent on beta-catenin activity. | Kim et al. | 2010 | 20126544 | Cell line | MCF-7 | Viability | Luminescence | TRC shRNA Library | Kinases | shRNA | B-score | < -1 | Essential gene: gene with B-score < -1 for > | GR00221-A-2 | 7046 | | TGFBR1 | TRCN0000039777 | -0.15 | none | | yes | | Proliferation of cells with active beta-catenin (2) | CK1epsilon is required for breast cancers dependent on beta-catenin activity. | Kim et al. | 2010 | 20126544 | Cell line | MDA-MB-231 | Viability | Luminescence | TRC shRNA Library | Kinases | shRNA | B-score | < -1 | Essential gene: gene with B-score < -1 for > | GR00221-A-3 | 7046 | | TGFBR1 | TRCN0000039777 | -0.07 | none | | yes | | Proliferation of cells with active beta-catenin (3) | CK1epsilon is required for breast cancers dependent on beta-catenin activity. | Kim et al. | 2010 | 20126544 | Cell line | MDA-MB-453 | Viability | Luminescence | TRC shRNA Library | Kinases | shRNA | B-score | < -1 | Essential gene: gene with B-score < -1 for > | GR00221-A-4 | 7046 | | TGFBR1 | TRCN0000039777 | -1.44 | Decreased viability | | no | | Proliferation of cells with active beta-catenin (4) | CK1epsilon is required for breast cancers dependent on beta-catenin activity. | Kim et al. | 2010 | 20126544 | Cell line | T47D | Viability | Luminescence | TRC shRNA Library | Kinases | shRNA | B-score | < -1 | Essential gene: gene with B-score < -1 for > | GR00221-A-4 | 7046 | | TGFBR1 | TRCN0000039776 | -0.09 | none | | no | | Proliferation of cells with active beta-catenin (4) | CK1epsilon is required for breast cancers dependent on beta-catenin activity. | Kim et al. | 2010 | 20126544 | Cell line | T47D | Viability | Luminescence | TRC shRNA Library | Kinases | shRNA | B-score | < -1 | Essential gene: gene with B-score < -1 for > | GR00221-A-4 | 7046 | | TGFBR1 | TRCN0000039773 | 1.37 | none | | no | | Proliferation of cells with active beta-catenin (4) | CK1epsilon is required for breast cancers dependent on beta-catenin activity. | Kim et al. | 2010 | 20126544 | Cell line | T47D | Viability | Luminescence | TRC shRNA Library | Kinases | shRNA | B-score | < -1 | Essential gene: gene with B-score < -1 for > | GR00225-A | 7046 | | TGFBR1 | TGFBR1_A | -0.052035 | none | 5nM gemcitabine | no | | Combinatorial effect with gemcitabine | Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. | Azorsa et al. | 2009 | 19519883 | Cell line | MIAPaCa-2 | Viability (synthetic lethal) | Luminescence | Validated kinase siRNA library version 1.0 | Kinases | siRNA | log2 ratio | 1.65 SD below mean ratio level | | GR00225-A | 7046 | | TGFBR1 | TGFBR1_A | -0.876898 | none | 10nM gemcitabine | no | | Combinatorial effect with gemcitabine | Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. | Azorsa et al. | 2009 | 19519883 | Cell line | MIAPaCa-2 | Viability (synthetic lethal) | Luminescence | Validated kinase siRNA library version 1.0 | Kinases | siRNA | log2 ratio | 1.65 SD below mean ratio level | | GR00225-A | 7046 | | TGFBR1 | TGFBR1_B | -0.136172 | none | 5nM gemcitabine | no | | Combinatorial effect with gemcitabine | Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. | Azorsa et al. | 2009 | 19519883 | Cell line | MIAPaCa-2 | Viability (synthetic lethal) | Luminescence | Validated kinase siRNA library version 1.0 | Kinases | siRNA | log2 ratio | 1.65 SD below mean ratio level | | GR00225-A | 7046 | | TGFBR1 | TGFBR1_B | -1.356919 | none | 10nM gemcitabine | no | | Combinatorial effect with gemcitabine | Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. | Azorsa et al. | 2009 | 19519883 | Cell line | MIAPaCa-2 | Viability (synthetic lethal) | Luminescence | Validated kinase siRNA library version 1.0 | Kinases | siRNA | log2 ratio | 1.65 SD below mean ratio level | | | 7046 | NM_004612 | TGFBR1 | np | 1.187214 | none | | no | | | | | | | | | | | | | | | | | GR00231-A | 7046 | NM_004612 | TGFBR1 | M-003929-01 | -0.283 | none | | yes | | Cell proliferation | Time-resolved human kinome RNAi screen identifies a network regulating mitotic-events as early regulators of cell proliferation. | Zhang et al. | 2011 | 21765947 | Cell line | HeLa | Viability | Electrical impedance | Human siARRAY - Protein Kinase and Cell Cycle libraries | Kinases and selected genes | siRNA | Z-score | < -1.96 OR > 1.96 | Additional information about cell titer blue cell viability screen | GR00233-A-1 | 7046 | 7046 | TGFBR1 | np | np | Increased JFH-1 genotype 2a Hepatitis C virus (HCV) infection | | yes | | Hepatitis C virus (HCV) infection (1) | A genome-wide genetic screen for host factors required for hepatitis C virus propagation. | Li et al. | 2009 | 19717417 | Cell line | Huh7.5.1 | HCV core protein expression and DNA content after virus infection | Fluorescence | Human Genome siARRAY siRNA G-005000–05 | Genome-wide | siRNA | Percentage of infected cells | < | | GR00234-A-1 | 7046 | NM_004612 | TGFBR1 | np | sp | none | | no | | Hepatitis C virus (HCV) infection (1) | EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. | Lupberger et al. | 2011 | 21516087 | Cell line | Huh7 | Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) protein expression | Luminescence | Human Kinase RNAi Set V2.0 | Kinases | siRNA | Complex, sp | Complex criteria | | GR00236-A-1 | 7046 | 7046 | TGFBR1 | M-003929-01 | 1.07536650830182 | none | | no | | Homologous recombination DNA double-strand break repair (HR-DSBR) (1) | A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. | Adamson et al. | 2012 | 22344029 | Cell line | DR-U2OS | (HR-DSBR) DR-GFP reporter and DNA content | Fluorescence | Human siGENOME siRNA (G-005000-05) | Genome-wide | siRNA | Relative HR ratio | < ~0.4 OR > 1.88 | Cutoff values correspond 2 standard deviations from the screen-wide mean | GR00240-S-1 | 7046 | NM_004612 | TGFBR1 | M-003929-01 | -0.05 | none | | yes | | TRAIL-induced apoptosis (1) | A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. | Kranz and Boutros | 2014 | 24442637 | Cell line | U251MG | Viability | Luminescence | SMART-pool siRNA | Genome-wide | siRNA | Z-score | > 4 | Author-submitted data | GR00240-S-2 | 7046 | NM_004612 | TGFBR1 | M-003929-01 | 1.21 | none | | no | Z-score 1.421 | TRAIL-induced apoptosis (2) | A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. | Kranz and Boutros | 2014 | 24442637 | Cell line | U251MG | Viability (synthetic lethal) | Luminescence | SMART-pool siRNA | Genome-wide | siRNA | Differential score | > 3.6 AND viability Z-score < 4 | Author-submitted data. Z-scores from viability screen (1) are considered in score interpretation for this screen. | GR00242-A-1 | 7046 | NM_004612 | TGFBR1 | np | sp | none | | no | | Selective autophagy regulation (1) | Image-based genome-wide siRNA screen identifies selective autophagy factors. | Orvedahl et al. | 2011 | 22020285 | Cell line | HeLa/GFP-LC3 | Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression | Fluorescence | siGenome | Genome-wide | siRNA | Z-score | Complex criteria | | GR00247-A-1 | 7046 | | TGFBR1 | np | sp | none | | | rank: 3665 | Regulation of FOXO1 nuclear localization (1) | Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain. | Senapedis et al. | 2011 | 21460183 | Cell line | U2OS | EGFP-FOXO1a protein expression and DNA content | Fluorescence | Human Genome library | Genome-wide | siRNA | Complex, sp | Complex criteria | | GR00248-A | 7046 | NM_004612 | TGFBR1 | TGFBR1_siRNA1 | -0.403 | none | | | | Human cytomegalovirus (HCMV) strain AD169 replication | Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. | Terry et al. | 2012 | 22315427 | Cell line | MRC5 | Human cytomegalovirus (HCMV) IE1 protein expression | Fluorescence | Mission siRNA Human Kinase Panel | Kinases | siRNA | Z-score | > | | GR00248-A | 7046 | NM_004612 | TGFBR1 | TGFBR1_siRNA2 | -0.887 | none | | | | Human cytomegalovirus (HCMV) strain AD169 replication | Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. | Terry et al. | 2012 | 22315427 | Cell line | MRC5 | Human cytomegalovirus (HCMV) IE1 protein expression | Fluorescence | Mission siRNA Human Kinase Panel | Kinases | siRNA | Z-score | > | | GR00248-A | 7046 | NM_004612 | TGFBR1 | TGFBR1_siRNA3 | 1.343 | none | | | | Human cytomegalovirus (HCMV) strain AD169 replication | Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. | Terry et al. | 2012 | 22315427 | Cell line | MRC5 | Human cytomegalovirus (HCMV) IE1 protein expression | Fluorescence | Mission siRNA Human Kinase Panel | Kinases | siRNA | Z-score | > | | GR00249-S | 7046 | 7046 | TGFBR1 | J-003929-09 | -0.02757 | none | | no | number of cells compared to control (%): 88.67 | Vaccinia virus (VACV) infection | Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan et al. | 2013 | 23401514 | Cell line | HeLa | Vaccinia virus VACV IHD-J/GFP protein expression and DNA content | Fluorescence | Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus | Genome-wide | siRNA | Z-score | > | Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. | GR00249-S | 7046 | 7046 | TGFBR1 | M-003929-02 | 0.71642 | Decreased viability | | no | number of cells compared to control (%): 48.40 | Vaccinia virus (VACV) infection | Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan et al. | 2013 | 23401514 | Cell line | HeLa | Vaccinia virus VACV IHD-J/GFP protein expression and DNA content | Fluorescence | Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus | Genome-wide | siRNA | Z-score | > | Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. | GR00249-S | 7046 | 7046 | TGFBR1 | s14071 | -0.95448 | Decreased viability | | no | number of cells compared to control (%): 49.10 | Vaccinia virus (VACV) infection | Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan et al. | 2013 | 23401514 | Cell line | HeLa | Vaccinia virus VACV IHD-J/GFP protein expression and DNA content | Fluorescence | Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus | Genome-wide | siRNA | Z-score | > | Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. | GR00249-S | 7046 | 7046 | TGFBR1 | s14072 | 0.02076 | none | | no | number of cells compared to control (%): 79.04 | Vaccinia virus (VACV) infection | Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan et al. | 2013 | 23401514 | Cell line | HeLa | Vaccinia virus VACV IHD-J/GFP protein expression and DNA content | Fluorescence | Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus | Genome-wide | siRNA | Z-score | > | Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. | GR00249-S | 7046 | 7046 | TGFBR1 | s14073 | -0.44132 | none | | no | number of cells compared to control (%): 59.24 | Vaccinia virus (VACV) infection | Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan et al. | 2013 | 23401514 | Cell line | HeLa | Vaccinia virus VACV IHD-J/GFP protein expression and DNA content | Fluorescence | Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus | Genome-wide | siRNA | Z-score | > | Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. | GR00253-A | 7046 | NM_004612 | TGFBR1 | np | 1.597 | none | | | | hepcidin regulation | Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. | Mleczko-Sanecka et al. | 2014 | 24385536 | Cell line | Huh7 | hepcidin::fluc mRNA expression | Luminescence | siGenome siARRAY SMARTpool | Genome-wide | siRNA | Z-score | > | Cutoff < | GR00255-A-1 | 7046 | 7046 | TGFBR1 | TRCN0000010441, TRCN0000010442, TRCN0000010443, TRCN0000039773, TRCN0000039774, TRCN0000039775, TRCN0000039776, TRCN0000039777 | 0.76034429 | none | | | | Negative genetic interactions (1) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.0 | HCT116 BLM-/- and HCT116 BLM+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-2 | 7046 | 7046 | TGFBR1 | TRCN0000010441, TRCN0000010442, TRCN0000010443, TRCN0000039773, TRCN0000039774, TRCN0000039775, TRCN0000039776, TRCN0000039777 | 1.137765256 | none | | | | Negative genetic interactions (2) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.0 | HCT116 MUS81-/- and HCT116 MUS81+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-3 | 7046 | 7046 | TGFBR1 | TRCN0000010441, TRCN0000010442, TRCN0000010443, TRCN0000039773, TRCN0000039774, TRCN0000039775, TRCN0000039776, TRCN0000039777 | 0.843600948 | none | | | | Negative genetic interactions (3) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.2 | HCT116 PTEN-/- and HCT116 PTEN+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-4 | 7046 | 7046 | TGFBR1 | TRCN0000010441, TRCN0000010442, TRCN0000010443, TRCN0000039773, TRCN0000039774, TRCN0000039775, TRCN0000039776, TRCN0000039777 | -0.680682139 | none | | | | Negative genetic interactions (4) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -1.2 | HCT116 PTTG1-/- and HCT116 PTTG1+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00255-A-5 | 7046 | 7046 | TGFBR1 | TRCN0000010441, TRCN0000010442, TRCN0000010443, TRCN0000039773, TRCN0000039774, TRCN0000039775, TRCN0000039776, TRCN0000039777 | -0.615759873 | none | | | | Negative genetic interactions (5) | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. | Vizeacoumar et al. | 2013 | 24104479 | Cell line | HCT116 | shRNA abundance | Microarray | np | Genome-wide | shRNA | differential Gene Activity Ranking Profile (dGARP) | < -0.8 | HCT116 KRASG13D/- and HCT116 KRAS+/- cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) | GR00256-A | 7046 | NM_004612 | TGFBR1 | np | sp | none | | | | Kinase-mediated spindle orientation | ABL1 regulates spindle orientation in adherent cells and mammalian skin. | Matsumara et al. | 2012 | 22252550 | Cell line | HeLa | beta-tubulin protein expression and DNA content | Fluorescence | Silencer Kinase siRNA library (AM80010V3) | Kinases | siRNA | Complex, sp | Complex criteria | HeLa cells stably expressing GFP-H2B (HeLa-GH2B) used. Additional information about secondary screens. | GR00293-A | 7046 | | TGFBR1 | np | 0.808 | none | | | | Combinatorial effect with paclitaxel | Mechanisms Promoting Escape from Mitotic Stress−Induced Tumor Cell Death | Sinnott et al. | 2014 | 24860162 | Cell line | HCC366 | Viability | Luminescence | Thermo-Fisher | Genome-wide | siRNA | Z-score | < -2.5 | Final hits according to the author are indicated in the comment. | GR00300-A | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000039773, TRCN0000039774, TRCN0000196293, TRCN0000010443, TRCN0000010442, TRCN0000196326, TRCN0000039775, TRCN0000039776, TRCN0000039777, TRCN0000195626, TRCN0000194693, TRCN0000196309 | 0 | none | | | | Combinatorial effect with RAF inhibitor PLX4720 | A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition. | Whittaker et al. | 2013 | 23288408 | Cell line | A375 | shRNA abundance | Sequencing | TRC | Genome-wide | shRNA | Number of shRNAs ranked Top1000 | > 2 | The A375 cell line used here harbours the BRAF V600E mutation and is therefore sensitive to RAF inhibitors. | GR00303-A | 7046 | NM_004612 | TGFBR1 | np | -0.38 | none | | | | Clear cell renal cell carcinoma (ccRCC) survival regulation | Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target | Gerlinger et al. | 2012 | 22362593 | Cell line | VHL-deficient RCC4 | Proliferation and Viability | Fluorescence | np | Genome-wide | siRNA | Z-score | < | In the phenotype data duplicates were in the original document, which have been removed. | GR00310-A-1 | 7046 | 7046 | TGFBR1 | np | 1.46 | none | | | | Sindbis virus (SINV) infection (1) | Genome-Wide RNAi Screen Identifies Novel Host Proteins Required for Alphavirus Entry | Ooi et al. | 2013 | 24367265 | Cell line | U2OS | Sindbis virus (SINV) reporter | Luminescence | Ambion Silencer V3 | Genome-wide | siRNA | Z-score | < -3 OR > 2 | | | 7046 | 7046 | TGFBR1 | np | 31.6 | none | | | 108,3% viability | | | | | | | | | | | | | | | | GR00313-A | 7046 | NM_004612 | TGFBR1 | np | 1.18 | none | | | | TNF-alpha pathway regulation | A Genome-Wide RNA Interference Screen Identifies Caspase 4 as a Factor Required for Tumor Necrosis Factor Alpha Signaling. | Nickles et al. | 2012 | 22733992 | Cell line | HEK293T | NFkappaB pathway reporter | Luminescence | Qiagen | Genome-wide | siRNA | Z-score | < | Additional filters were a reduction in firefly luciferase levels by at least 50% compared to the mean of the experiment and a concomitant reduction of renilla luciferase expression of not more than 30%. | GR00318-A | 7046 | 7046 | TGFBR1 | np | 1.738 | none | | | siRNA set: kinase | Huntingtin toxicity | A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington’s Disease | Miller et al. | 2012 | 23209424 | Cell line | HEK293T | Caspase 3/7 activity | Fluorescence | Dharmacon | Selected genes | siRNA | Sum of normalized caspase 3/7 activity mean and standard error | < 0.683 | HEK293T cells were cotransfected with mutant Huntingtin fused to GFP (Htt1-558141Q-GFP). | GR00327-A | 7046 | 4484 | MGAM | CLL-H-016819 | -0.6931787588041675 | none | | | | Tumor formation | An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation | Wolf et al. | 2013 | 24292671 | Cell line | SUM-149 | shRNA abundance | Next-generation sequencing | Decipher library module 1 | Selected genes | shRNA | Z-score | > 2.24 | Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. | GR00327-A | 7046 | 4484 | MGAM | CLL-H-016818 | np | none | | | | Tumor formation | An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation | Wolf et al. | 2013 | 24292671 | Cell line | SUM-149 | shRNA abundance | Next-generation sequencing | Decipher library module 1 | Selected genes | shRNA | Z-score | > 2.24 | Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. | GR00327-A | 7046 | 4484 | MGAM | CLL-H-016816 | 0.22001530624944038 | none | | | | Tumor formation | An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation | Wolf et al. | 2013 | 24292671 | Cell line | SUM-149 | shRNA abundance | Next-generation sequencing | Decipher library module 1 | Selected genes | shRNA | Z-score | > 2.24 | Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. | GR00327-A | 7046 | 4484 | MGAM | CLL-H-016817 | 0.49112271842033367 | none | | | | Tumor formation | An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation | Wolf et al. | 2013 | 24292671 | Cell line | SUM-149 | shRNA abundance | Next-generation sequencing | Decipher library module 1 | Selected genes | shRNA | Z-score | > 2.24 | Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. | GR00327-A | 7046 | 4484 | MGAM | CLL-H-016820 | -2.2074788090443462 | none | | | | Tumor formation | An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation | Wolf et al. | 2013 | 24292671 | Cell line | SUM-149 | shRNA abundance | Next-generation sequencing | Decipher library module 1 | Selected genes | shRNA | Z-score | > 2.24 | Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. | GR00342-S-1 | 7046 | | TGFBR1 | M-003929-01 | -0.7894726508818734 | none | | | | Viability of Mesenchymal Stem Cells (MSC) (1) | Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening | Erdmann et al. | 2015 | 26120366 | Primary cells | Bone marrow derived MSC | Viability | Luminescence | Kinase siGENOME SMARTpool library | Kinases and phosphatases | siRNA | Z-score | > | Donor 1, MSC preparation 1 (MSC1a) | GR00342-S-2 | 7046 | | TGFBR1 | M-003929-01 | -0.41461445353766413 | none | | | | Viability of Mesenchymal Stem Cells (MSC) (2) | Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening | Erdmann et al. | 2015 | 26120366 | Primary cells | Bone marrow derived MSC | Viability | Luminescence | Kinase siGENOME SMARTpool library | Kinases and phosphatases | siRNA | Z-score | > | Donor 1, MSC preparation 2 (MSC1b) | GR00342-S-3 | 7046 | | TGFBR1 | M-003929-01 | -0.31580549031188054 | none | | | | Viability of Mesenchymal Stem Cells (MSC) (3) | Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening | Erdmann et al. | 2015 | 26120366 | Primary cells | Bone marrow derived MSC | Viability | Luminescence | Kinase siGENOME SMARTpool library | Kinases and phosphatases | siRNA | Z-score | > | Donor 2, MSC preparation 1 (MSC2) | GR00343-S | 7046 | 7046 | TGFBR1 | TRCN0000039776 | -3.1624999999999988 | shRNA abundance <= 25% | | | | Lentiviral shRNA "Achilles Heel" screen | Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia | Cole et al. | 2015 | 26058080 | Cell line | K562 | shRNA abundance | Fluorescence | Lentiviral shRNA library | Genome-wide | shRNA | Log2 ratio | < | Comparison of day 21 vs. day 0 abundance data | GR00343-S | 7046 | 7046 | TGFBR1 | TRCN0000039773 | 2.1875 | none | | | | Lentiviral shRNA "Achilles Heel" screen | Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia | Cole et al. | 2015 | 26058080 | Cell line | K562 | shRNA abundance | Fluorescence | Lentiviral shRNA library | Genome-wide | shRNA | Log2 ratio | < | Comparison of day 21 vs. day 0 abundance data | GR00343-S | 7046 | 7046 | TGFBR1 | TRCN0000010443 | -0.6699999999999999 | none | | | | Lentiviral shRNA "Achilles Heel" screen | Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia | Cole et al. | 2015 | 26058080 | Cell line | K562 | shRNA abundance | Fluorescence | Lentiviral shRNA library | Genome-wide | shRNA | Log2 ratio | < | Comparison of day 21 vs. day 0 abundance data | GR00343-S | 7046 | 7046 | TGFBR1 | TRCN0000039775 | 1.0600000000000005 | none | | | | Lentiviral shRNA "Achilles Heel" screen | Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia | Cole et al. | 2015 | 26058080 | Cell line | K562 | shRNA abundance | Fluorescence | Lentiviral shRNA library | Genome-wide | shRNA | Log2 ratio | < | Comparison of day 21 vs. day 0 abundance data | GR00343-S | 7046 | 7046 | TGFBR1 | TRCN0000010441 | 1.5050000000000008 | none | | | | Lentiviral shRNA "Achilles Heel" screen | Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia | Cole et al. | 2015 | 26058080 | Cell line | K562 | shRNA abundance | Fluorescence | Lentiviral shRNA library | Genome-wide | shRNA | Log2 ratio | < | Comparison of day 21 vs. day 0 abundance data | GR00343-S | 7046 | 7046 | TGFBR1 | TRCN0000039777 | 0.7125000000000004 | none | | | | Lentiviral shRNA "Achilles Heel" screen | Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia | Cole et al. | 2015 | 26058080 | Cell line | K562 | shRNA abundance | Fluorescence | Lentiviral shRNA library | Genome-wide | shRNA | Log2 ratio | < | Comparison of day 21 vs. day 0 abundance data | GR00343-S | 7046 | 7046 | TGFBR1 | TRCN0000039774 | 0.3000000000000007 | none | | | | Lentiviral shRNA "Achilles Heel" screen | Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia | Cole et al. | 2015 | 26058080 | Cell line | K562 | shRNA abundance | Fluorescence | Lentiviral shRNA library | Genome-wide | shRNA | Log2 ratio | < | Comparison of day 21 vs. day 0 abundance data | | 7046 | NM_004612 | TGFBR1 | M-003929-01 | np | none | | | | | | | | | | | | | | | | | | | | 7046 | NM_004612 | TGFBR1 | M-003929-01 | 2.49 | Decreased infection with West Nile virus (WNV) | | | 3.26 | | | | | | | | | | | | | | | | | 7046 | TGFBR1 | NM_004612 | D-003929-07 | 2.4 | Decreased West Nile virus (WNV) infection | | | 4.1 | | | | | | | | | | | | | | | | | 7046 | TGFBR1 | NM_004612 | D-003929-08 | 2.6 | Decreased West Nile virus (WNV) infection | | | 4.5 | | | | | | | | | | | | | | | | GR00356-A-1 | 7046 | NM_004612 | TGFBR1 | np | 4.24 | Increased vesicular stomatitis virus (VSV) infection | | | | Clathrin-mediated endocytosis | Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. | Pelkmans et al. | 2005 | 15889048 | Cell line | HeLa | Vesicular stomatitis virus (VSV) infection (rVSV–GFP expression) | Fluorescence | Ambion | Kinases | siRNA | Relative infection index (RII) | < | The cutoff was < 0.4 OR > 2.5 if the gene also scored in the additional screen "Caveolin- and lipid raft-mediated endocytosis" using simian virus 40 (SV40). | GR00356-A-2 | 7046 | NM_004612 | TGFBR1 | np | 0.567374600553909 | none | | | | Caveolin- and lipid raft-mediated endocytosis | Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. | Pelkmans et al. | 2005 | 15889048 | Cell line | HeLa | Simian virus 40 (SV40) infection (SV40 large T-antigen expression) | Fluorescence | Ambion | Kinases | siRNA | Relative infection index (RII) | < | The cutoff was < 0.4 OR > 2.5 if the gene also scored in the additional screen "Clathrin-mediated endocytosis" using vesicular stomatitis virus (VSV). | GR00356-A-3 | 7046 | NM_004612 | TGFBR1 | np | np | Transferrin accumulation in small spots in the cell periphery | | | | Endocytosis regulation | Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. | Pelkmans et al. | 2005 | 15889048 | Cell line | HeLa | Transferrin (Tfn) uptake and trafficking | Fluorescence | Ambion | Kinases | siRNA | np | np | | GR00364-A | 7046 | 7046 | TGFBR1 | np | -3.868105652464713 | Decreased Salmonella proliferation | | | | Salmonella infection | Human Genome-Wide RNAi Screen for Host Factors that modulate intracellular Salmonella Growth | Thornbrough et al. | 2012 | 3372477 | Cell line | MCF-7 | Intracellular bacterial proliferation | Fluorescence | siRNA library v1.0, Qiagen | Genome-wide | siRNA | Standard deviations | > | | GR00365-A | 7046 | 7046 | TGFBR1 | np | sp | Condensed cis-Golgi, condensed trans-Golgi | | | validated by deconvoluted siRNA | Golgi morphology | RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cells | Chia et al. | 2012 | 23212246 | Cell line | HeLa | Golgi morphology | Fluorescence | Dharmacon | Kinases and phosphatases | siRNA | Ratio | > | | GR00366-A-1 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.409495454384458 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (1) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | 22RV1_PROSTATE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-10 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.518373485552353 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (10) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | ACHN_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-100 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.95273148752769 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (100) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LAMA84_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-101 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.574862921675099 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (101) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LK2_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-102 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.275402063165234 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (102) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN215_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-103 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.383445931036709 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (103) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN229_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-104 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.472037160486083 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (104) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN235_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-105 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.00343579086828732 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (105) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN319_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-106 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.318871622257038 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (106) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN340_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-107 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.972872989490722 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (107) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN382_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-108 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.223223206003516 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (108) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN428_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-109 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.447029854671333 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (109) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN443_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-11 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 2.34202458113441 | Increased shRNA abundance (Z-score > 2) | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (11) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | AGS_STOMACH | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-110 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.308123576597076 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (110) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LN464_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-111 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.213785469775758 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (111) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LNZ308_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-112 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.529979392731554 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (112) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LOVO_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-113 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.048582873146802 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (113) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LS411N_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-114 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 1.20314702499661 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (114) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | LS513_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-115 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.949974490787361 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (115) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MCF7_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-116 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.699073427649038 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (116) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MDAMB453_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-117 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.490174433741432 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (117) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MIAPACA2_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-118 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.706867396230685 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (118) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MKN7_STOMACH | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-119 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.533353104153262 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (119) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-12 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.460852833081257 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (12) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | AM38_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-120 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.355037384193089 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (120) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-121 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 1.26930870992657 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (121) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-122 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.912331945635327 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (122) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MONOMAC6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-123 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 1.3046879549797 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (123) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | MV411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-124 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.751948114274199 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (124) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-125 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.688538597988879 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (125) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-126 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.362873381324988 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (126) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1299_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-127 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.363295901451355 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (127) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1437_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-128 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.0419872501381137 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (128) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1650_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-129 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -1.02099574260667 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (129) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1792_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-13 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.574852976582896 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (13) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | AML193_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-130 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.491493353017133 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (130) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH196_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-131 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.0276324024523624 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (131) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH1975_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-132 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.0977334385717954 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (132) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH2052_PLEURA | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-133 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.201732300398567 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (133) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH2122_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-134 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.700761573485026 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (134) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH2171_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-135 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.045570857796384 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (135) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH23_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-136 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.317974249171756 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (136) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH2452_PLEURA | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-137 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.212906385188965 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (137) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH441_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-138 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.47548882146687 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (138) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH508_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-139 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.669900753462495 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (139) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH660_PROSTATE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-14 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.417436468963184 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (14) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | ASPC1_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-140 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.273788362672261 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (140) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH661_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-141 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.0611826040982607 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (141) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH716_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-142 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.0855871468906134 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (142) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIH838_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-143 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.230624547787917 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (143) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NCIN87_STOMACH | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-144 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.279733765421801 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (144) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NIHOVCAR3_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-145 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.0129227428526963 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (145) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | NOMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-146 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.216083044601598 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (146) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OAW42_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-147 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 1.43096058977163 | Increased shRNA abundance (Z-score > 2) | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (147) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-148 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.220184288136668 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (148) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-149 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.0465168118321757 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (149) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-15 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.290720277150501 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (15) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | BT20_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-150 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.421919985141234 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (150) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OE33_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-151 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.201257428076685 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (151) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OELE_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-152 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 1.22726538046602 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (152) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-153 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.11535978109189 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (153) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OV7_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-154 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.0057274958663897 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (154) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OV90_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-155 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 1.08526454124795 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (155) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OVCAR4_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-156 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.0315268604989053 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (156) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OVCAR8_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-157 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.27373310749055 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (157) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | OVISE_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-158 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.122440787645331 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (158) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PANC0327_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-159 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.253053082634931 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (159) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PANC0813_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-16 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.728026080956633 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (16) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | BT474_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-160 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.555806075688281 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (160) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PANC1005_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-161 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.237470712893124 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (161) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PLB985_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-162 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.23795079358049 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (162) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | PSN1_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-163 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.450927453875756 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (163) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | QGP1_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-164 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.504332294592141 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (164) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-165 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -1.31777444419113 | Decreased shRNA abundance (Z-score < -2) | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (165) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RKN_SOFT_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-166 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.426859672724016 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (166) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RKO_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-167 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.0990871029479019 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (167) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RMGI_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-168 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.305453215278203 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (168) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RMUGS_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-169 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 1.38594537289573 | Increased shRNA abundance (Z-score > 2) | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (169) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-17 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.000134401742258239 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (17) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | BXPC3_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-170 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.201621017289359 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (170) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | RT112_URINARY_TRACT | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-171 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.22400868763258 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (171) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-172 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.806836714372646 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (172) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SF126_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-173 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 1.16067708760035 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (173) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SF172_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-174 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.274431213746483 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (174) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SF295_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-175 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.326506998652975 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (175) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SF767_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-176 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.309849550821339 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (176) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SJSA1_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-177 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.280170406207511 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (177) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKCO1_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-178 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.630642708252781 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (178) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKMEL5_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-179 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.362419648747313 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (179) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKMM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-18 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.345979302110325 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (18) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | C2BBE1_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-180 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -1.55496653712749 | Decreased shRNA abundance (Z-score < -2) | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (180) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKNO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-181 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -1.08165608085587 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (181) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKOV3_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-182 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.371371859007978 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (182) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SKRC20_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-183 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.51705643321147 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (183) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR20_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-184 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.536262380488713 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (184) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR21_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-185 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.275479484968358 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (185) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR23_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-186 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.163943787122365 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (186) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR24_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-187 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.0835548385521717 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (187) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR25_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-188 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 1.15478224969292 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (188) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SLR26_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-189 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.377526977014872 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (189) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SNU1105_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-19 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.467928652545774 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (19) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | C32_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-190 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.402100376937725 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (190) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SNU840_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-191 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.527027979265596 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (191) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SNUC1_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-192 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.344581445969453 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (192) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SNUC2A_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-193 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.109816254632239 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (193) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SU8686_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-194 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.358600465134524 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (194) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SW1417_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-195 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.121205253281166 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (195) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SW1783_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-196 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.482764657052922 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (196) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SW480_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-197 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.0585242376719642 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (197) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | SW48_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-198 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.535336262880312 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (198) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | T98G_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-199 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.652883741418558 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (199) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TC71_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-2 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.133821431809689 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (2) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | 697_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-20 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.188520222268013 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (20) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CADOES1_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-200 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 1.39358397457721 | Increased shRNA abundance (Z-score > 2) | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (200) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TCCSUP_URINARY_TRACT | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-201 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -1.17566533338039 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (201) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TE10_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-202 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.546696182589553 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (202) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TE15_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-203 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.588272991047494 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (203) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TE9_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-204 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.303540693562823 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (204) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-205 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.323781894349787 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (205) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TOV112D_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-206 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.0309734526439468 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (206) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TOV21G_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-207 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.273162662010965 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (207) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TT_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-208 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.566617625438013 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (208) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | TYKNU_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-209 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.0949188935707164 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (209) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | U178_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-21 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.27953167499216 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (21) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAL120_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-210 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -1.05118334411067 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (210) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | U251MG_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-211 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.736257744223994 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (211) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | U343_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-212 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.290970717073586 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (212) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | U87MG_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-213 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.15147488906842 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (213) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | UOK101_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-214 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.592567290111816 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (214) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | VCAP_PROSTATE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-215 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.0281108119614354 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (215) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | YKG1_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-216 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.278704711878515 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (216) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | ZR7530_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-22 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 1.65560378503918 | Increased shRNA abundance (Z-score > 2) | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (22) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAL51_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-23 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.721260615331395 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (23) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CALU1_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-24 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.0600770090581871 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (24) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAOV3_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-25 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.758991237279541 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (25) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAOV4_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-26 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.033429455598542 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (26) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CAS1_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-27 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.987945315277482 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (27) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CFPAC1_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-28 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.2742932191216 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (28) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CH157MN_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-29 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.83826461215453 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (29) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COLO205_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-3 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.539726575952759 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (3) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | 786O_KIDNEY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-30 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.749577608604329 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (30) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COLO704_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-31 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.074478783127233 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (31) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COLO741_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-32 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.681444541776444 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (32) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COLO783_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-33 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.04759929134803 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (33) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | CORL23_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-34 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.0682394292405315 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (34) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COV362_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-35 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.0428226157586081 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (35) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COV434_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-36 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -1.28448363072384 | Decreased shRNA abundance (Z-score < -2) | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (36) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COV504_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-37 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 1.59448691633069 | Increased shRNA abundance (Z-score > 2) | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (37) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | COV644_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-38 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.0834093734928514 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (38) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | DBTRG05MG_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-39 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.234284772234122 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (39) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | DKMG_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-4 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.123994773554107 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (4) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A1207_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-40 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.791389132560399 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (40) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | DLD1_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-41 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.223867123381477 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (41) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EFE184_ENDOMETRIUM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-42 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.439583975855718 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (42) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EFM19_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-43 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.0701276716135985 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (43) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EFO21_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-44 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.197067485147606 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (44) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EFO27_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-45 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.882813040698371 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (45) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EW8_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-46 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.0202893084896196 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (46) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | EWS502_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-47 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.0669748521239224 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (47) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | F36P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-48 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.553089040821454 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (48) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | GB1_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-49 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.424916198955501 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (49) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | GP2D_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-5 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.0428288984971125 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (5) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A172_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-50 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.469635364891383 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (50) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC1187_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-51 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.420127027446057 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (51) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC1395_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-52 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.3162377578135 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (52) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC1954_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-53 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.260707070886251 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (53) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC2218_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-54 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.0578939491875746 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (54) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC2814_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-55 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.410704746982023 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (55) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC364_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-56 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.625555149065619 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (56) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC44_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-57 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.771395168051688 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (57) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC70_BREAST | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-58 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.235076515114447 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (58) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC827GR5_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-59 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.000238332742862767 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (59) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCC827_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-6 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.440978981623014 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (6) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A204_SOFT_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-60 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 1.57283339991094 | Increased shRNA abundance (Z-score > 2) | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (60) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HCT116_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-61 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.209701215402341 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (61) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HEC1A_ENDOMETRIUM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-62 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.27627745762376 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (62) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HEYA8_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-63 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.355594322995606 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (63) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-64 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.380289010278 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (64) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HLF_LIVER | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-65 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.87220934507058 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (65) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HNT34_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-66 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.519928418721947 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (66) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HPAC_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-67 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.130551086478941 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (67) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HPAFII_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-68 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.220983961935641 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (68) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HS683_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-69 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.17076810713416 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (69) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HS766T_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-7 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.559678098724085 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (7) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A2058_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-70 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.16345695432053 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (70) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HS944T_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-71 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.560404742255358 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (71) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HT1197_URINARY_TRACT | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-72 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.414063908442261 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (72) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HT29_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-73 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.648850803783568 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (73) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HT55_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-74 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.261397497305451 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (74) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HUG1N_STOMACH | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-75 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.321389325422724 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (75) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | HUTU80_SMALL_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-76 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.319854687958551 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (76) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | IGR39_SKIN | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-77 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 1.48734981197 | Increased shRNA abundance (Z-score > 2) | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (77) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | IGROV1_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-78 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.472062689013963 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (78) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | IOMMLEE_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-79 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.520769912210096 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (79) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | JHESOAD1_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-8 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.919438662600992 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (8) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A549_LUNG | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-80 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.401526853914835 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (80) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | JHOC5_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-81 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.16760021839126 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (81) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | JHOM1_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-82 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.252242767114926 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (82) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-83 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.0763101544154115 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (83) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-84 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.702908294597173 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (84) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KALS1_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-85 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 2.76638030575865 | Increased shRNA abundance (Z-score > 2) | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (85) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-86 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.717197563046991 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (86) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KM12_LARGE_INTESTINE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-87 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.108079586396414 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (87) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-88 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 1.47111399430025 | Increased shRNA abundance (Z-score > 2) | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (88) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KNS60_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-89 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.346171084526957 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (89) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KNS81_CENTRAL_NERVOUS_SYSTEM | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-9 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.962984360450863 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (9) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | A673_BONE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-90 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.48971987132069 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (90) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KP1NL_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-91 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.0880332581436027 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (91) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KP2_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-92 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.217873863754011 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (92) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KP4_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-93 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.373769905924585 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (93) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KURAMOCHI_OVARY | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-94 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.45338371401569 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (94) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KYSE150_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-95 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.304340651468202 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (95) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KYSE30_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-96 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.59594090029036 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (96) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KYSE450_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-97 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.0573703800236847 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (97) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | KYSE510_OESOPHAGUS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-98 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | -0.213168908234477 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (98) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | L33_PANCREAS | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | GR00366-A-99 | 7046 | | TGFBR1 | TRCN0000010441, TRCN0000010443, TRCN0000221533, TRCN0000221534, TRCN0000221535, TRCN0000221536, TRCN0000221537 | 0.218280962805895 | none | | | TGFBR1_1_1111111 | Context-specific genetic dependencies (99) | Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies | Cowley et al. | 2014 | 25984343 | Cell line | L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | shRNA abundance | Next-generation sequencing | TRC | shRNA | Genome-wide | Fold change | np (default cutoff applied: Z-score > 2 OR < -2) | Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) | | 7046 | 7046 | TGFBR1 | | -0.15000000000000002 | none | | | | | | | | | | | | | | | | | | | GR00371-A-1 | 7046 | 7046 | TGFBR1 | | -0.416361814112 | none | | | Dharmacon | Nanog expression in absence of bFGF and TGFbeta | Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways | Gonzales et al. | 2015 | 26232226 | Cell line | NANOG-GFP H1 hESC | NANOG expression | Fluorescence | Dharmacon and Ambion | Selected genes | siRNA | Z-score | >1,25 OR >1,5 [in at least two replicates] | Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted. | GR00371-A-1 | 7046 | 7046 | TGFBR1 | | -0.802232313245 | none | | | Ambion | Nanog expression in absence of bFGF and TGFbeta | Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways | Gonzales et al. | 2015 | 26232226 | Cell line | NANOG-GFP H1 hESC | NANOG expression | Fluorescence | Dharmacon and Ambion | Selected genes | siRNA | Z-score | >1,25 OR >1,5 [in at least two replicates] | Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted. | GR00371-A-2 | 7046 | TGFBR1 | 7046 | | -1.14942060104 | none | | | Ambion | Nanog expression in presence of TGFbeta inhibitor | Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways | Gonzales et al. | 2015 | 26232226 | Cell line | NANOG-GFP H1 hESC | NANOG expression | Fluorescence | Dharmacon and Ambion | Selected genes | siRNA | Z-score | >1,25 OR >1,5 [in at least two replicates] | Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted. | GR00371-A-2 | 7046 | TGFBR1 | 7046 | | -0.324958550502 | none | | | Dharmacon | Nanog expression in presence of TGFbeta inhibitor | Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways | Gonzales et al. | 2015 | 26232226 | Cell line | NANOG-GFP H1 hESC | NANOG expression | Fluorescence | Dharmacon and Ambion | Selected genes | siRNA | Z-score | >1,25 OR >1,5 [in at least two replicates] | Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted. | GR00371-A-3 | 7046 | 7046 | TGFBR1 | | -0.0381933542791 | none | | | Dharmacon | Nanog expression in presence of MEK inhibitor | Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways | Gonzales et al. | 2015 | 26232226 | Cell line | NANOG-GFP H1 hESC | NANOG expression | Fluorescence | Dharmacon and Ambion | Selected genes | siRNA | Z-score | >1,25 OR >1,5 [in at least two replicates] | Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted. | GR00371-A-3 | 7046 | 7046 | TGFBR1 | | -1.62019199217 | none | | | Ambion | Nanog expression in presence of MEK inhibitor | Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways | Gonzales et al. | 2015 | 26232226 | Cell line | NANOG-GFP H1 hESC | NANOG expression | Fluorescence | Dharmacon and Ambion | Selected genes | siRNA | Z-score | >1,25 OR >1,5 [in at least two replicates] | Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted. | GR00371-A-4 | 7046 | 7046 | TGFBR1 | | -1.02984378305 | none | | | Ambion | Nanog expression in presence of PI3K inhibitor | Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways | Gonzales et al. | 2015 | 26232226 | Cell line | NANOG-GFP H1 hESC | NANOG expression | Fluorescence | Dharmacon and Ambion | Selected genes | siRNA | Z-score | >1,25 OR >1,5 [in at least two replicates] | Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted. | GR00371-A-4 | 7046 | 7046 | TGFBR1 | | -0.302506854831 | none | | | Dharmacon | Nanog expression in presence of PI3K inhibitor | Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways | Gonzales et al. | 2015 | 26232226 | Cell line | NANOG-GFP H1 hESC | NANOG expression | Fluorescence | Dharmacon and Ambion | Selected genes | siRNA | Z-score | >1,25 OR >1,5 [in at least two replicates] | Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted. | GR00371-A-5 | 7046 | 7046 | TGFBR1 | | -1.10926843324 | none | | | Dharmacon | Nanog expression in presence of retinoic acid | Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways | Gonzales et al. | 2015 | 26232226 | Cell line | NANOG-GFP H1 hESC | NANOG expression | Fluorescence | Dharmacon and Ambion | Selected genes | siRNA | Z-score | >1,25 OR >1,5 [in at least two replicates] | Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted. | GR00371-A-5 | 7046 | 7046 | TGFBR1 | | -1.52752152213 | none | | | Ambion | Nanog expression in presence of retinoic acid | Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways | Gonzales et al. | 2015 | 26232226 | Cell line | NANOG-GFP H1 hESC | NANOG expression | Fluorescence | Dharmacon and Ambion | Selected genes | siRNA | Z-score | >1,25 OR >1,5 [in at least two replicates] | Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted. | GR00376-A-1 | 7046 | 7046 | TGFBR1 | | 0.061667396 | none | | | | Mitigators of SS1P-induced immunotoxicity | Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity | Pasetto et al. | 2015 | 25713356 | Cell line | KB cells | Viability | Luminescence | Ambion Silencer Select Version 4 | Genome-wide | siRNA | RSA P-value | <0.001 | SS1P was applied in a "high dose", ≈EC90, 13 ng/ml. Cutoff was derived from data submitted to Pubchem (ID 1117281). Reagent sequences but no ID | GR00376-A-2 | 7046 | 7046 | TGFBR1 | | 0.698032904 | none | | | | Sensitizers of SS1P-induced immunotoxicity | Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity | Pasetto et al. | 2015 | 25713356 | Cell line | KB cells | Viability | Luminescence | Ambion Silencer Select Version 4 | Genome-wide | siRNA | RSA P-value | <0.001 | SS1P was applied in a "low dose", ≈EC30, 3 ng/ml. Cutoff was derived from data submitted to PubChem (ID 1117281). Reagent sequences but no ID | GR00378-A | 7046 | | TGFBR1 | | -0.227928294 | none | | | | Poliovirus vaccine production | Engineering Enhanced Vaccine Cell Lines To Eradicate Vaccine-Preventable Diseases: the Polio End Game | van der Sanden et al. | 2015 | 26581994 | Cell line | HEp-2C | Infection with Attenuated Poliovirus | ELISA | Dharmacon | Genome-wide | siRNA | Z-score | > | For infection, a single lot of the attenuated Sabin type 2 poliovirus was used for the screen. Gene IDs were not provided, only the gene name/symbol | | 7046 | NM_004612 | TGFBR1 | | 75.51 | none | | | | | | | | | | | | | | | | | | | GR00386-A-1 | 7046 | 7046 | TGFBR1 | | 91.0247138676513 | none | | | | NOD2 stimulation by MDP | A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. | Warner et al. | 2014 | 25170077 | Cell line | HEK293 stably expressing NOD2 | Viability | Luminescence | Dharmacon | Genome-wide | siRNA | Percentage growth | Decreased: <70, increased: >120 | Reagent IDs not provided | GR00386-A-2 | 7046 | 7046 | TGFBR1 | | -100.8 | none | | | | MDP-induced IL-8 secretion | A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. | Warner et al. | 2014 | 25170077 | Cell line | HEK293 stably expressing NOD2 | IL-8 secretion | ELISA | Dharmacon | Genome-wide | siRNA | Percent inhibition of IL-8 secretion | Increased: <-300, Decreased: >60 | Concentration of IL-8 was measured from cell supernatants by sandwich ELISA. IL-8 values (pg/ml) were normalized to IL-8 secreted in cells treated with RIPK2-specific siRNA (100% inhibition) and non-targeting siRNA (0% inhibition). Secondary validating screen assessed 554 genes whose silencing affected MDP-induced IL-8 secretion in the primary screen. Final validated IL-8 regulators (positive or negative) are listed in the comments column. Reagent IDs not provided |