RNAi

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:9288
  • Symbol:TAAR3P
  • Description:trace amine associated receptor 3, pseudogene
DataSource: http://genomernai.dkfz.de/v16/genedetails/9288

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Stable_ID Entrez_ID Gene_ID Gene_Symbol Reagent_ID Score Phenotype Conditions Follow_Up Comment Screen_Title Publication_Title Authors Publication_Year Pubmed_ID Biosource Biomodel Assay Method Library Scope Reagent_Type Score_Type Cutoff Notes
GR00133-A-1 9288 9288 GPR57 np 0.101845 none no Salmonella enterica subspecies 1 serovar Typhimurium invasion (1) RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42. Misselwitz et al. 2011 21407211 Cell line HeLa Gentamycin protection invasion assay Fluorescence Druggable genome library V2.0 Druggable genes siRNA log2 median Complex criteria
GR00247-A-1 9288 GPR58 np sp none rank: 9811 Regulation of FOXO1 nuclear localization (1) Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain. Senapedis et al. 2011 21460183 Cell line U2OS EGFP-FOXO1a protein expression and DNA content Fluorescence Human Genome library Genome-wide siRNA Complex, sp Complex criteria
GR00290-A 9288 9288 TAAR3 SI04389147 1 Increased centriole number Centriole biogenesis Discovering Regulators of Centriole Biogenesis through siRNA-Based Functional Genomics in Human Cells Balestra et al. 2013 23769972 Cell line HeLa Centriole number Fluorescence Qiagen Genome-wide siRNA Phenotype strength 0: none, 1: weak, 2: clear, 3: strong For alternative scores (RSA and Top2) see publication.
GR00290-A 9288 9288 TAAR3 SI04389112 0 none Centriole biogenesis Discovering Regulators of Centriole Biogenesis through siRNA-Based Functional Genomics in Human Cells Balestra et al. 2013 23769972 Cell line HeLa Centriole number Fluorescence Qiagen Genome-wide siRNA Phenotype strength 0: none, 1: weak, 2: clear, 3: strong For alternative scores (RSA and Top2) see publication.
GR00290-A 9288 9288 TAAR3 SI04389084 1 Increased centriole number Centriole biogenesis Discovering Regulators of Centriole Biogenesis through siRNA-Based Functional Genomics in Human Cells Balestra et al. 2013 23769972 Cell line HeLa Centriole number Fluorescence Qiagen Genome-wide siRNA Phenotype strength 0: none, 1: weak, 2: clear, 3: strong For alternative scores (RSA and Top2) see publication.
GR00290-A 9288 9288 TAAR3 SI04389175 0 none Centriole biogenesis Discovering Regulators of Centriole Biogenesis through siRNA-Based Functional Genomics in Human Cells Balestra et al. 2013 23769972 Cell line HeLa Centriole number Fluorescence Qiagen Genome-wide siRNA Phenotype strength 0: none, 1: weak, 2: clear, 3: strong For alternative scores (RSA and Top2) see publication.
GR00293-A 9288 GPR58 np -0.142 none Combinatorial effect with paclitaxel Mechanisms Promoting Escape from Mitotic Stressāˆ’Induced Tumor Cell Death Sinnott et al. 2014 24860162 Cell line HCC366 Viability Luminescence Thermo-Fisher Genome-wide siRNA Z-score < -2.5 Final hits according to the author are indicated in the comment.
GR00313-A 9288 BC095548 TAAR3 np 0.34 none TNF-alpha pathway regulation A Genome-Wide RNA Interference Screen Identifies Caspase 4 as a Factor Required for Tumor Necrosis Factor Alpha Signaling. Nickles et al. 2012 22733992 Cell line HEK293T NFkappaB pathway reporter Luminescence Qiagen Genome-wide siRNA Z-score < Additional filters were a reduction in firefly luciferase levels by at least 50% compared to the mean of the experiment and a concomitant reduction of renilla luciferase expression of not more than 30%.