Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:10013
  • Symbol:HDAC6
  • Description:histone deacetylase 6

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
10013 GO:0000118 IDA part_of histone deacetylase complex 11948178 Component
10013 GO:0005654 IDA located_in nucleoplasm Component
10013 GO:0005737 IDA located_in cytoplasm 24687993 Component
10013 GO:0005813 IDA located_in centrosome Component
10013 GO:0005829 IDA located_in cytosol Component
10013 GO:0005874 IDA located_in microtubule 12620231 Component
10013 GO:0005875 IDA part_of microtubule associated complex 19228685 Component
10013 GO:0005901 IDA located_in caveola 18356165 Component
10013 GO:0016234 IDA located_in inclusion body 16192271 Component
10013 GO:0016235 IDA located_in aggresome 14675537 Component
10013 GO:0031252 IDA located_in cell leading edge 12024216 Component
10013 GO:0036064 IDA located_in ciliary basal body 17604723 Component
10013 GO:0048471 IDA located_in perinuclear region of cytoplasm 12024216 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
10013 GO:0000978 IDA enables RNA polymerase II cis-regulatory region sequence-specific DNA binding 24413532 Function
10013 GO:0001222 IPI enables transcription corepressor binding 12535528 Function
10013 GO:0004407 IDA enables histone deacetylase activity 10220385 Function
10013 GO:0004407 IMP enables histone deacetylase activity 23322205 Function
10013 GO:0005515 IPI enables protein binding 16919237,17604723,17872950,18356165,19033385,19036992,19081074..... Function
10013 GO:0008013 IPI enables beta-catenin binding 18356165 Function
10013 GO:0008017 IDA enables microtubule binding 19228685 Function
10013 GO:0031593 IDA enables polyubiquitin modification-dependent protein binding 14675537 Function
10013 GO:0031625 IPI enables ubiquitin protein ligase binding 21753002 Function
10013 GO:0033558 IDA enables protein lysine deacetylase activity 28516954 Function
10013 GO:0042826 IPI enables histone deacetylase binding 12620231 Function
10013 GO:0042903 IDA enables tubulin deacetylase activity 12620231,19228685,20308065 Function
10013 GO:0042903 IMP enables tubulin deacetylase activity 19457097 Function
10013 GO:0043014 IDA enables alpha-tubulin binding 19228685 Function
10013 GO:0047611 IDA NOT enables acetylspermidine deacetylase activity 28516954 Function
10013 GO:0048156 IDA enables tau protein binding 18636984 Function
10013 GO:0051787 EXP enables misfolded protein binding 17785525 Function
10013 GO:0051879 IDA enables Hsp90 protein binding 15916966 Function
10013 GO:0070840 IDA enables dynein complex binding 14675537 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
10013 GO:0006476 IDA involved_in protein deacetylation 28516954 Process
10013 GO:0006476 IMP involved_in protein deacetylation 15916966 Process
10013 GO:0006515 IMP involved_in protein quality control for misfolded or incompletely synthesized proteins 14675537 Process
10013 GO:0006886 IMP involved_in intracellular protein transport 16192271 Process
10013 GO:0010634 IMP involved_in positive regulation of epithelial cell migration 12024216 Process
10013 GO:0016241 IMP involved_in regulation of macroautophagy 16192271 Process
10013 GO:0016575 IDA involved_in histone deacetylation 10220385 Process
10013 GO:0019896 IGI involved_in axonal transport of mitochondrion 28105056 Process
10013 GO:0031333 IMP involved_in negative regulation of protein-containing complex assembly 23962722 Process
10013 GO:0031647 IMP involved_in regulation of protein stability 23580651 Process
10013 GO:0032418 IMP involved_in lysosome localization 16192271 Process
10013 GO:0033138 IMP involved_in positive regulation of peptidyl-serine phosphorylation 23962722 Process
10013 GO:0034983 IMP involved_in peptidyl-lysine deacetylation 18356165,18606987,23962722 Process
10013 GO:0035967 IMP involved_in cellular response to topologically incorrect protein 16192271 Process
10013 GO:0040029 IMP involved_in epigenetic regulation of gene expression 24413532 Process
10013 GO:0043242 IMP involved_in negative regulation of protein-containing complex disassembly 15916966 Process
10013 GO:0045861 IMP involved_in negative regulation of proteolysis 18356165 Process
10013 GO:0051788 IMP involved_in response to misfolded protein 14675537 Process
10013 GO:0061523 IMP involved_in cilium disassembly 17604723 Process
10013 GO:0061734 IGI involved_in parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization 20457763 Process
10013 GO:0070301 IMP involved_in cellular response to hydrogen peroxide 18606987 Process
10013 GO:0070842 IMP involved_in aggresome assembly 14675537 Process
10013 GO:0070845 IMP involved_in polyubiquitinated misfolded protein transport 14675537 Process
10013 GO:0070848 IMP involved_in response to growth factor 18356165 Process
10013 GO:0090042 IDA involved_in tubulin deacetylation 19228685,20308065,23093407 Process
10013 GO:0106047 IDA NOT involved_in polyamine deacetylation 28516954 Process
10013 GO:0106048 IDA NOT involved_in spermidine deacetylation 28516954 Process
10013 GO:2000273 IMP acts_upstream_of positive regulation of signaling receptor activity 15916966,18316616 Process