Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:10021
  • Symbol:HCN4
  • Description:hyperpolarization activated cyclic nucleotide gated potassium channel 4

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
10021 GO:0002027 IMP involved_in regulation of heart rate 16407510 Process
10021 GO:0003254 IDA involved_in regulation of membrane depolarization 12750403,16043489 Process
10021 GO:0006812 IDA involved_in monoatomic cation transport 12750403 Process
10021 GO:0035725 IMP involved_in sodium ion transmembrane transport 22748890 Process
10021 GO:0042391 IMP involved_in regulation of membrane potential 22748890 Process
10021 GO:0055117 IMP involved_in regulation of cardiac muscle contraction 12750403 Process
10021 GO:0071320 IDA involved_in cellular response to cAMP 12750403,16043489,16407510,22748890 Process
10021 GO:0071321 IDA involved_in cellular response to cGMP 22748890 Process
10021 GO:0071805 IDA involved_in potassium ion transmembrane transport 16407510 Process
10021 GO:0071805 IMP involved_in potassium ion transmembrane transport 22748890 Process
10021 GO:0086015 IMP involved_in SA node cell action potential 12750403 Process
10021 GO:0086046 IMP involved_in membrane depolarization during SA node cell action potential 16407510 Process
10021 GO:0086091 IMP involved_in regulation of heart rate by cardiac conduction 12750403 Process
10021 GO:0098719 IDA involved_in sodium ion import across plasma membrane 10228147 Process
10021 GO:0098909 IMP involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction 16407510 Process
10021 GO:1990573 IDA involved_in potassium ion import across plasma membrane 10228147 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
10021 GO:0005222 IDA enables intracellular cAMP-activated cation channel activity 10228147,12750403,16407510 Function
10021 GO:0005248 IMP enables voltage-gated sodium channel activity 22748890 Function
10021 GO:0005249 IDA enables voltage-gated potassium channel activity 16407510 Function
10021 GO:0005249 IMP enables voltage-gated potassium channel activity 22748890 Function
10021 GO:0042802 IPI enables identical protein binding 22006928,24776929 Function
10021 GO:0086041 IMP enables voltage-gated potassium channel activity involved in SA node cell action potential depolarization 16407510 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
10021 GO:0005886 IDA located_in plasma membrane 12750403,16407510,22748890 Component
10021 GO:0048471 IDA located_in perinuclear region of cytoplasm 12750403 Component
10021 GO:0098855 IDA part_of HCN channel complex 10228147,16407510 Component
10021 GO:0098855 IPI part_of HCN channel complex 20829353 Component