Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:10075
  • Symbol:HUWE1
  • Description:HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
10075 GO:0000209 IDA involved_in protein polyubiquitination 15989957 Process
10075 GO:0006284 IMP involved_in base-excision repair 19713937 Process
10075 GO:0006513 IDA involved_in protein monoubiquitination 19713937 Process
10075 GO:0010637 IMP involved_in negative regulation of mitochondrial fusion 26214738 Process
10075 GO:0031398 IDA involved_in positive regulation of protein ubiquitination 20534529 Process
10075 GO:0032922 IMP involved_in circadian regulation of gene expression 20534529 Process
10075 GO:0098779 IDA involved_in positive regulation of mitophagy in response to mitochondrial depolarization 30217973 Process
10075 GO:1903955 HMP involved_in positive regulation of protein targeting to mitochondrion 24270810 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
10075 GO:0003723 HDA enables RNA binding 22658674 Function
10075 GO:0004842 IDA enables ubiquitin-protein transferase activity 15989957,19713937 Function
10075 GO:0005515 IPI enables protein binding 15989956,19713937,20023629,20534529,21507240,21522127,25277244..... Function
10075 GO:0061630 IDA enables ubiquitin protein ligase activity 30217973 Function
10075 GO:0061630 IMP enables ubiquitin protein ligase activity 26214738 Function
10075 GO:0140852 IDA enables histone ubiquitin ligase activity 15767685 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
10075 GO:0005654 IDA located_in nucleoplasm Component
10075 GO:0005737 IDA located_in cytoplasm 19713937 Component
10075 GO:0005829 IDA located_in cytosol Component
10075 GO:0016020 HDA located_in membrane 19946888 Component
10075 GO:0070062 HDA located_in extracellular exosome 19056867 Component