Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:1019
  • Symbol:CDK4
  • Description:cyclin dependent kinase 4

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1019 GO:0000082 IDA involved_in G1/S transition of mitotic cell cycle 19237565 Process
1019 GO:0000082 IMP involved_in G1/S transition of mitotic cell cycle 7603984 Process
1019 GO:0006468 IDA involved_in protein phosphorylation 8114739 Process
1019 GO:0008284 IMP involved_in positive regulation of cell population proliferation 7603984 Process
1019 GO:0009410 IEP involved_in response to xenobiotic stimulus 18291362 Process
1019 GO:0010468 IMP involved_in regulation of gene expression 17420273 Process
1019 GO:0010971 IDA involved_in positive regulation of G2/M transition of mitotic cell cycle 19124461 Process
1019 GO:0048146 IMP involved_in positive regulation of fibroblast proliferation 17420273 Process
1019 GO:0051726 IDA involved_in regulation of cell cycle 19124461 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1019 GO:0000307 IDA part_of cyclin-dependent protein kinase holoenzyme complex 17420273,18827403 Component
1019 GO:0000785 IDA part_of chromatin 18827403 Component
1019 GO:0005634 IDA located_in nucleus 16109376,18827403,20399237 Component
1019 GO:0005654 IDA located_in nucleoplasm Component
1019 GO:0005730 IDA located_in nucleolus 18827403 Component
1019 GO:0005829 IDA located_in cytosol 18827403 Component
1019 GO:0031965 IDA located_in nuclear membrane 18827403 Component
1019 GO:0097128 IPI part_of cyclin D1-CDK4 complex 19237565 Component
1019 GO:0097129 IPI part_of cyclin D2-CDK4 complex 11896535 Component
1019 GO:0097130 IPI part_of cyclin D3-CDK4 complex 19237555 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1019 GO:0004693 IDA enables cyclin-dependent protein serine/threonine kinase activity 8114739,19237565 Function
1019 GO:0005515 IPI enables protein binding 7568034,8078588,8259215,8741839,8756624,9106657,9150368,952924..... Function
1019 GO:0030332 IPI enables cyclin binding 19124461 Function