Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:1111
  • Symbol:CHEK1
  • Description:checkpoint kinase 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1111 GO:0000077 IDA involved_in DNA damage checkpoint signaling 16963448 Process
1111 GO:0000077 IMP involved_in DNA damage checkpoint signaling 19716789 Process
1111 GO:0006281 IMP involved_in DNA repair 19716789 Process
1111 GO:0006468 IDA involved_in protein phosphorylation 33108758 Process
1111 GO:0006915 IDA involved_in apoptotic process 23028632 Process
1111 GO:0006974 IMP involved_in DNA damage response 20932473 Process
1111 GO:0007095 IMP involved_in mitotic G2 DNA damage checkpoint signaling 20932473 Process
1111 GO:0010569 IDA involved_in regulation of double-strand break repair via homologous recombination 15665856 Process
1111 GO:0018107 IDA involved_in peptidyl-threonine phosphorylation 15665856 Process
1111 GO:0042770 IDA involved_in signal transduction in response to DNA damage 16963448 Process
1111 GO:0044818 IMP involved_in mitotic G2/M transition checkpoint 33108758 Process
1111 GO:0045787 IDA involved_in positive regulation of cell cycle 26296656 Process
1111 GO:0045839 IDA involved_in negative regulation of mitotic nuclear division 15311285 Process
1111 GO:0046602 IDA involved_in regulation of mitotic centrosome separation 15311285 Process
1111 GO:0071260 IEP involved_in cellular response to mechanical stimulus 19593445 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1111 GO:0000781 IDA colocalizes_with chromosome, telomeric region 15149599 Component
1111 GO:0000794 IDA located_in condensed nuclear chromosome 9382850 Component
1111 GO:0005615 HDA located_in extracellular space 23580065 Component
1111 GO:0005634 IDA located_in nucleus 15311285,20932473,26296656 Component
1111 GO:0005654 IDA located_in nucleoplasm Component
1111 GO:0005737 IDA located_in cytoplasm 26296656 Component
1111 GO:0005813 IDA located_in centrosome 15311285 Component
1111 GO:0032991 IDA part_of protein-containing complex 26296656 Component
1111 GO:0043231 IDA located_in intracellular membrane-bounded organelle Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1111 GO:0004672 IMP enables protein kinase activity 22024163 Function
1111 GO:0004674 IDA enables protein serine/threonine kinase activity 16963448 Function
1111 GO:0005515 IPI enables protein binding 11836499,15665856,15798197,16330544,16963448,17380128,19223857..... Function
1111 GO:0019904 IPI enables protein domain specific binding 26296656 Function
1111 GO:0035402 IDA enables histone H3T11 kinase activity 18243098 Function