Gene Ontology

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:12363
  • Symbol:Casp4
  • Description:caspase 4, apoptosis-related cysteine peptidase

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
12363 GO:0001530 IDA enables lipopolysaccharide binding 25119034,37001519 Function
12363 GO:0004197 IDA enables cysteine-type endopeptidase activity 30135078,32109412,34671164 Function
12363 GO:0004197 IMP enables cysteine-type endopeptidase activity 30392956 Function
12363 GO:0005515 IPI enables protein binding 30692621 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
12363 GO:0005737 IDA is_active_in cytoplasm 16670335 Component
12363 GO:0005829 IDA is_active_in cytosol 16670335 Component
12363 GO:0160074 IDA part_of non-canonical inflammasome complex 23887873,30135078 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
12363 GO:0010934 IGI acts_upstream_of macrophage cytokine production 22002608 Process
12363 GO:0016540 IDA involved_in protein autoprocessing 32109412 Process
12363 GO:0016540 IMP involved_in protein autoprocessing 30392956 Process
12363 GO:0032497 IDA involved_in detection of lipopolysaccharide 23887873,24031018,30589883 Process
12363 GO:0032611 IGI acts_upstream_of interleukin-1 beta production 22002608 Process
12363 GO:0032731 IGI acts_upstream_of_or_within positive regulation of interleukin-1 beta production 22002608 Process
12363 GO:0035234 IGI acts_upstream_of_or_within ectopic germ cell programmed cell death 11536012 Process
12363 GO:0035234 IMP acts_upstream_of_or_within ectopic germ cell programmed cell death 11536012 Process
12363 GO:0042742 IDA involved_in defense response to bacterium 25119034 Process
12363 GO:0042742 IMP involved_in defense response to bacterium 23348507 Process
12363 GO:0050727 IDA involved_in regulation of inflammatory response 32109412 Process
12363 GO:0050729 IDA involved_in positive regulation of inflammatory response 30392956,34671164 Process
12363 GO:0050729 IMP involved_in positive regulation of inflammatory response 23348507 Process
12363 GO:0050830 IDA involved_in defense response to Gram-positive bacterium 30392956 Process
12363 GO:0051604 IDA involved_in protein maturation 30135078 Process
12363 GO:0060907 IGI acts_upstream_of_or_within positive regulation of macrophage cytokine production 22002608 Process
12363 GO:0070269 IDA involved_in pyroptosis 30135078,30589883,32109412,34671164 Process
12363 GO:0070269 IMP acts_upstream_of_or_within pyroptosis 22002608 Process
12363 GO:0070269 IMP involved_in pyroptosis 23348507 Process
12363 GO:0160075 IDA involved_in non-canonical inflammasome complex assembly 23887873,24031018,25119034,30135078,30589883 Process
12363 GO:0160075 IMP involved_in non-canonical inflammasome complex assembly 22895188 Process
12363 GO:1900227 IDA involved_in positive regulation of NLRP3 inflammasome complex assembly 26173909 Process
12363 GO:2000494 IDA involved_in positive regulation of interleukin-18-mediated signaling pathway 30392956 Process