Gene Ontology

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:12370
  • Symbol:Casp8
  • Description:caspase 8

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
12370 GO:0001525 IMP acts_upstream_of_or_within angiogenesis 12404118 Process
12370 GO:0001525 IMP involved_in angiogenesis 31748744 Process
12370 GO:0001817 IDA involved_in regulation of cytokine production 32971525 Process
12370 GO:0001841 IMP acts_upstream_of_or_within neural tube formation 12404118 Process
12370 GO:0006915 IDA acts_upstream_of_or_within apoptotic process 16183742 Process
12370 GO:0006919 IDA acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process 12011074 Process
12370 GO:0007507 IMP acts_upstream_of_or_within heart development 12404118 Process
12370 GO:0007507 IMP involved_in heart development 31748744 Process
12370 GO:0008625 IMP acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors 15322156 Process
12370 GO:0016485 IDA involved_in protein processing 30361383 Process
12370 GO:0030225 IMP acts_upstream_of_or_within macrophage differentiation 15322156 Process
12370 GO:0043065 IDA acts_upstream_of_or_within positive regulation of apoptotic process 9654089 Process
12370 GO:0043065 IMP acts_upstream_of_or_within positive regulation of apoptotic process 9654089 Process
12370 GO:0043065 IMP involved_in positive regulation of apoptotic process 24813849,24813850 Process
12370 GO:0045088 IDA involved_in regulation of innate immune response 32971525 Process
12370 GO:0051603 IDA involved_in proteolysis involved in protein catabolic process 32971525 Process
12370 GO:0060546 IGI acts_upstream_of_or_within negative regulation of necroptotic process 21368763,21402742,22037414,22089168 Process
12370 GO:0060546 IMP involved_in negative regulation of necroptotic process 31511692,31748744,31827281 Process
12370 GO:0070243 IGI acts_upstream_of_or_within regulation of thymocyte apoptotic process 15456877 Process
12370 GO:0070266 IGI acts_upstream_of necroptotic process 21368763,21402742,22037414 Process
12370 GO:0070269 IDA involved_in pyroptosis 30361383 Process
12370 GO:0070269 IMP involved_in pyroptosis 31748744 Process
12370 GO:0097190 IDA acts_upstream_of_or_within apoptotic signaling pathway 16183742 Process
12370 GO:0097191 IDA acts_upstream_of_or_within extrinsic apoptotic signaling pathway 10588860,12065591 Process
12370 GO:0097191 IGI acts_upstream_of_or_within extrinsic apoptotic signaling pathway 22089168,22675671 Process
12370 GO:0097191 IMP involved_in extrinsic apoptotic signaling pathway 31748744 Process
12370 GO:0097194 IMP involved_in execution phase of apoptosis 24813849,24813850 Process
12370 GO:0097264 IMP involved_in self proteolysis 31511692 Process
12370 GO:0097284 IMP acts_upstream_of_or_within hepatocyte apoptotic process 15322156 Process
12370 GO:2001233 IGI acts_upstream_of_or_within regulation of apoptotic signaling pathway 15456877 Process
12370 GO:2001238 IGI acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway 16183742 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
12370 GO:0004175 IDA enables endopeptidase activity 22037414,32971525 Function
12370 GO:0004175 IMP enables endopeptidase activity 22037414 Function
12370 GO:0004197 IDA enables cysteine-type endopeptidase activity 15456877,30361383 Function
12370 GO:0004197 IGI enables cysteine-type endopeptidase activity 21368763 Function
12370 GO:0004197 IMP enables cysteine-type endopeptidase activity 31511692,31748744 Function
12370 GO:0005515 IPI enables protein binding 11684016,15383280,16469705,17159908,17170703,18455983,18946037..... Function
12370 GO:0008233 IDA enables peptidase activity 11369777 Function
12370 GO:0008233 IMP enables peptidase activity 12404118 Function
12370 GO:0097153 IDA enables cysteine-type endopeptidase activity involved in apoptotic process 12065591,16183742 Function
12370 GO:0097153 IMP enables cysteine-type endopeptidase activity involved in apoptotic process 31827281 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
12370 GO:0005634 IDA located_in nucleus 12065591 Component
12370 GO:0005737 IDA located_in cytoplasm 10638761,12065591 Component
12370 GO:0005739 HDA located_in mitochondrion 18614015 Component
12370 GO:0005886 IDA located_in plasma membrane 10638761 Component
12370 GO:0030690 IMP part_of Noc1p-Noc2p complex 14657025 Component