Gene Ontology

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:12649
  • Symbol:Chek1
  • Description:checkpoint kinase 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
12649 GO:0000077 IDA acts_upstream_of_or_within DNA damage checkpoint signaling 12529385 Process
12649 GO:0000077 IMP acts_upstream_of_or_within DNA damage checkpoint signaling 10859164 Process
12649 GO:0000086 IMP acts_upstream_of_or_within G2/M transition of mitotic cell cycle 10859164 Process
12649 GO:0001833 IMP acts_upstream_of_or_within inner cell mass cell proliferation 10859163 Process
12649 GO:0006281 IDA acts_upstream_of_or_within DNA repair 15364958 Process
12649 GO:0006338 IDA involved_in chromatin remodeling 18243098 Process
12649 GO:0006468 IDA acts_upstream_of_or_within protein phosphorylation 15364958 Process
12649 GO:0006974 IDA acts_upstream_of_or_within DNA damage response 11790307,12529385 Process
12649 GO:0006974 IMP involved_in DNA damage response 18243098 Process
12649 GO:0006997 IMP acts_upstream_of_or_within nucleus organization 10859163 Process
12649 GO:0007093 IMP acts_upstream_of_or_within mitotic cell cycle checkpoint signaling 10859163 Process
12649 GO:0010468 IGI acts_upstream_of_or_within regulation of gene expression 21737879 Process
12649 GO:0042127 IMP acts_upstream_of_or_within regulation of cell population proliferation 21737879 Process
12649 GO:0045814 IMP involved_in negative regulation of gene expression, epigenetic 18243098 Process
12649 GO:1902742 IMP acts_upstream_of_or_within apoptotic process involved in development 10859163 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
12649 GO:0000785 IDA part_of chromatin 18243098 Component
12649 GO:0005634 IDA located_in nucleus 11555636 Component
12649 GO:0005657 IDA located_in replication fork 15364958 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
12649 GO:0004672 IMP enables protein kinase activity 15364958 Function
12649 GO:0005515 IPI enables protein binding 15364958,23418588 Function
12649 GO:0035402 IDA enables histone H3T11 kinase activity 18243098 Function