Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:1398
  • Symbol:CRK
  • Description:CRK proto-oncogene, adaptor protein

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1398 GO:0001784 IPI enables phosphotyrosine residue binding 20624904 Function
1398 GO:0005515 IPI enables protein binding 7561682,8524328,8626543,9472046,9546424,9788432,10733900,11316..... Function
1398 GO:0017124 IPI enables SH3 domain binding 12384576 Function
1398 GO:0019900 IPI enables kinase binding 18722344 Function
1398 GO:0035591 IDA enables signaling adaptor activity 12384576,17515907 Function
1398 GO:0042169 IPI enables SH2 domain binding 9472046 Function
1398 GO:0043621 IDA enables protein self-association 17515907 Function
1398 GO:0045309 IDA enables protein phosphorylated amino acid binding 12384576 Function
1398 GO:0046875 IPI enables ephrin receptor binding 11870224 Function
1398 GO:1990782 IPI enables protein tyrosine kinase binding 12384576 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1398 GO:0008360 IMP involved_in regulation of cell shape 17515907,31311869 Process
1398 GO:0009966 IDA involved_in regulation of signal transduction 17515907 Process
1398 GO:0030036 IMP involved_in actin cytoskeleton organization 31311869 Process
1398 GO:0032956 IDA involved_in regulation of actin cytoskeleton organization 11870224 Process
1398 GO:0043087 IDA involved_in regulation of GTPase activity 11870224 Process
1398 GO:0043393 IMP involved_in regulation of protein binding 17515907 Process
1398 GO:0048013 IDA involved_in ephrin receptor signaling pathway 11870224 Process
1398 GO:0061045 IDA involved_in negative regulation of wound healing 17515907 Process
1398 GO:0061045 IMP involved_in negative regulation of wound healing 17515907 Process
1398 GO:1900026 IMP involved_in positive regulation of substrate adhesion-dependent cell spreading 19004829 Process
1398 GO:1902531 IDA involved_in regulation of intracellular signal transduction 12384576 Process
1398 GO:2000146 IDA involved_in negative regulation of cell motility 17515907 Process
1398 GO:2000146 IMP involved_in negative regulation of cell motility 17515907 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1398 GO:0032991 IPI part_of protein-containing complex 12384576 Component
1398 GO:0070062 HDA located_in extracellular exosome 19056867 Component